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https://www.readbyqxmd.com/read/29474823/investigation-of-structure-and-function-of-mitochondrial-alcohol-dehydrogenase-isozyme-iii-from-komagataella-phaffii-gs115
#1
Huaidong Zhang, Qin Li, Lina Wang, Yan Chen
BACKGROUND: Alcohol dehydrogenases (ADHs) catalyze the reversible oxidation of alcohol using NAD+ or NADP+ as cofactor. Three ADH homologues have been identified in Komagataella phaffii GS115 (also named Pichia pastoris GS115), ADH1, ADH2 and ADH3, among which adh3 is the only gene responsible for consumption of ethanol in Komagataella phaffii GS115. However, the relationship between structure and function of mitochondrial alcohol dehydrogenase isozyme III from Komagataella phaffii GS115 (KpADH3) is still not clear yet...
February 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29474367/an-investigation-of-the-effect-of-race-based-social-categorization-on-adults-recognition-of-emotion
#2
B Nicole Reyes, Shira C Segal, Margaret C Moulson
Emotion recognition is important for social interaction and communication, yet previous research has identified a cross-cultural emotion recognition deficit: Recognition is less accurate for emotions expressed by individuals from a cultural group different than one's own. The current study examined whether social categorization based on race, in the absence of cultural differences, influences emotion recognition in a diverse context. South Asian and White Canadians in the Greater Toronto Area completed an emotion recognition task that required them to identify the seven basic emotional expressions when posed by members of the same two groups, allowing us to tease apart the contributions of culture and social group membership...
2018: PloS One
https://www.readbyqxmd.com/read/29473661/facial-emotion-recognition-in-parkinson-s-disease-a-review-and-new-hypotheses
#3
REVIEW
Soizic Argaud, Marc Vérin, Paul Sauleau, Didier Grandjean
Parkinson's disease is a neurodegenerative disorder classically characterized by motor symptoms. Among them, hypomimia affects facial expressiveness and social communication and has a highly negative impact on patients' and relatives' quality of life. Patients also frequently experience nonmotor symptoms, including emotional-processing impairments, leading to difficulty in recognizing emotions from faces. Aside from its theoretical importance, understanding the disruption of facial emotion recognition in PD is crucial for improving quality of life for both patients and caregivers, as this impairment is associated with heightened interpersonal difficulties...
February 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29472852/it-is-not-just-in-faces-processing-of-emotion-and-intention-from-biological-motion-in-psychiatric-disorders
#4
REVIEW
Łukasz Okruszek
Social neuroscience offers a wide range of techniques that may be applied to study the social cognitive deficits that may underlie reduced social functioning-a common feature across many psychiatric disorders. At the same time, a significant proportion of research in this area has been conducted using paradigms that utilize static displays of faces or eyes. The use of point-light displays (PLDs) offers a viable alternative for studying recognition of emotion or intention inference while minimizing the amount of information presented to participants...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29466804/phenotypic-variability-in-autosomal-dominant-familial-alzheimer-disease-due-to-the-s170f-mutation-of-presenilin-1
#5
Hannes O Tiedt, Beate Benjamin, Michael Niedeggen, Andreas Lueschow
BACKGROUND: In rare cases, patients with Alzheimer disease (AD) present at an early age and with a family history suggestive of an autosomal dominant mode of inheritance. Mutations of the presenilin-1 (PSEN1) gene are the most common causes of dementia in these patients. Early-onset and particularly familial AD patients frequently present with variable non-amnestic cognitive symptoms such as visual, language or behavioural changes as well as non-cognitive, e.g. motor, symptoms. OBJECTIVE: To investigate the phenotypic variability in carriers of the PSEN1 S170F mutation...
February 22, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29465776/fair-chances-and-hard-work-families-making-sense-of-inequality-and-opportunity-in-21st-century-britain
#6
Helene Snee, Fiona Devine
In British social mobility discourse, the rhetoric of fair access can obscure wider issues of social justice. While socio-economic inequalities continue to shape young people's lives, sociological work on class dis-identification suggests social class is less obviously meaningful as a source of individual and collective identity. This paper considers subjective understandings of the post-16 education and employment landscape in this context, drawing on qualitative research exploring the aspirations of young men and women as they completed compulsory education in north-west England, and the hopes their parents had for their future...
February 21, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29464518/erp-source-analysis-guided-by-fmri-during-familiar-face-processing
#7
Maria A Bobes, Agustin Lage-Castellanos, Ela I Olivares, Jhoanna Perez Hidalgo-Gato, Jaime Iglesias, Ana Maria Castro-Laguardia, Pedro Valdes-Sosa
Event related potentials (ERPs) provide precise temporal information about cognitive processing, but with poor spatial resolution, while functional magnetic resonance imaging (fMRI) reliably identifies brain areas involved, but with poor temporal resolution. Here we use fMRI to guide source localization of the ERPs at different times for studying the temporal dynamics of the neural system for recognizing familiar faces. fMRI activation areas were defined in a previous experiment applying the same paradigm used for ERPs...
February 20, 2018: Brain Topography
https://www.readbyqxmd.com/read/29463183/younger-and-older-adults-associative-memory-for-medication-interactions-of-varying-severity
#8
Mary B Hargis, Alan D Castel
While older adults face various deficits in binding items in memory, they are often able to remember information that is deemed important. In Experiment 1, we examined how younger and older adults remember medication interactions of varying severity. There were no age differences in overall memory accuracy, but older adults' performance depended on the severity of the interactions (such that the interactions associated with the most severe health outcomes were remembered most accurately) while younger adults' did not...
February 21, 2018: Memory
https://www.readbyqxmd.com/read/29461118/emotional-face-recognition-in-individuals-withattention-deficit-hyperactivity-disorder-a-review-article
#9
Khatereh Borhani, Vahid Nejati
This review focuses on facial emotion recognition (FER) in individuals with attention- deficit/hyperactivity disorder (ADHD). Behavioral studies of FER in ADHD have resulted in inconsistent findings. Here, we discuss the factors that vary across studies and the way that they influence FER processes in ADHD. Across reviewed studies, fear was the most deficient facial expression to be recognized. Our review suggested that FER deficit in ADHD does not alleviate across development and is partially distinct from ADHD symptoms...
February 20, 2018: Developmental Neuropsychology
https://www.readbyqxmd.com/read/29460469/further-delineation-of-an-entity-caused-by-crebbp-and-ep300-mutations-but-not-resembling-rubinstein-taybi-syndrome
#10
Leonie A Menke, Thatjana Gardeitchik, Peter Hammond, Ketil R Heimdal, Gunnar Houge, Sophia B Hufnagel, Jianling Ji, Stefan Johansson, Sarina G Kant, Esther Kinning, Eyby L Leon, Ruth Newbury-Ecob, Stefano Paolacci, Rolph Pfundt, Nicola K Ragge, Tuula Rinne, Claudia Ruivenkamp, Sulagna C Saitta, Yu Sun, Marco Tartaglia, Paulien A Terhal, Anthony J van Essen, Magnus D Vigeland, Bing Xiao, Raoul C Hennekam
In 2016, we described that missense variants in parts of exons 30 and 31 of CREBBP can cause a phenotype that differs from Rubinstein-Taybi syndrome (RSTS). Here we report on another 11 patients with variants in this region of CREBBP (between bp 5,128 and 5,614) and two with variants in the homologous region of EP300. None of the patients show characteristics typical for RSTS. The variants were detected by exome sequencing using a panel for intellectual disability in all but one individual, in whom Sanger sequencing was performed upon clinical recognition of the entity...
February 20, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29459198/the-educational-impact-of-web-based-and-face-to-face-patient-deterioration-simulation-programs-an-interventional-trial
#11
Catherine Chung, Simon J Cooper, Robyn P Cant, Cliff Connell, Angela McKay, Leigh Kinsman, Swapnali Gazula, Jayne Boyle, Amanda Cameron, Penny Cash, Lisa Evans, Jeong-Ah Kim, Rana Masud, Denise McInnes, Lisa Norman, Erika Penz, Thomas Rotter, Erin Tanti, Tom Breakspear
BACKGROUND: There are international concerns relating to the management of patient deterioration. The "failure to rescue" literature identifies that nursing staff miss cues of deterioration and often fail to call for assistance. Simulation-based educational approaches may improve nurses' recognition and management of patient deterioration. OBJECTIVES: To investigate the educational impact of the First2Act web-based (WB) and face-to-face (F2F) simulation programs...
February 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29454885/attending-to-identity-cues-reduces-the-own-age-but-not-the-own-race-recognition-advantage
#12
Valentina Proietti, Sarah Laurence, Claire M Matthew, Xiaomei Zhou, Catherine J Mondloch
Adults' ability to recognize individual faces is shaped by experience. Young adults recognize own-age and own-race faces more accurately than other-age and other-race faces. The own-age and own-race biases have been attributed to differential perceptual experience and to differences in how in-group vs. out-group faces are processed, with in-group faces being processed at the individual level and out-group faces being processed at the categorical level. To examine this social categorization hypothesis, young adults studied young and older faces in Experiment 1 and own- and other-race faces in Experiment 2...
February 15, 2018: Vision Research
https://www.readbyqxmd.com/read/29451074/negative-emotional-face-perception-is-diminished-on-a-very-early-level-of-processing-in-autism-spectrum-disorder
#13
Alexander Prehn-Kristensen, Anna Lorenzen, Fabian Grabe, Lioba Baving
Deficits in facial affect recognition (FAR) are often reported in autism spectrum disorders (ASD) due to inappropriate visual search strategies. It is unclear, however, whether or not deficits in subliminal FAR are still present in autism when visual focus is controlled. Thirteen persons with ASD and 13 healthy participants took part in this experiment. Supraliminal FAR was assessed using a standardized, computer-aided test. Subliminal FAR was obtained by an emotional face priming paradigm. By using an eye-tracking technique, it was assured that the initial visual focus was on the eyes of the prime...
February 16, 2018: Social Neuroscience
https://www.readbyqxmd.com/read/29450791/face-processing-skills-predict-faithfulness-of-portraits-drawn-by-novices
#14
Christel Devue, Gina M Grimshaw
Individuals show astonishing variability in their face recognition abilities, and the causes and consequences of this heterogeneity are unclear. Special expertise with faces, for example in portraitists, is associated with advantages on face processing tasks, especially those involving perceptual abilities. Do face processing skills improve through practice, or does drawing skill reflect pre-existing individual differences? If the latter, then the association between face processing skills and production of faithful portraits should also exist in people without practice in drawing...
February 15, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29445336/the-two-systems-account-of-theory-of-mind-testing-the-links-to-social-perceptual-and-cognitive-abilities
#15
Bozana Meinhardt-Injac, Moritz M Daum, Günter Meinhardt, Malte Persike
According to the two-systems account of theory of mind (ToM), understanding mental states of others involves both fast social-perceptual processes, as well as slower, reflexive cognitive operations (Frith and Frith, 2008; Apperly and Butterfill, 2009). To test the respective roles of specific abilities in either of these processes we administered 15 experimental procedures to a large sample of 343 participants, testing ability in face recognition and holistic perception, language, and reasoning. ToM was measured by a set of tasks requiring ability to track and to infer complex emotional and mental states of others from faces, eyes, spoken language, and prosody...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29444736/recognition-of-the-complexity-facing-residential-care-homes-a-practitioner-inquiry
#16
Jenny Dudman, Julienne Meyer, Cheryl Holman, Wendy Moyle
Aim To explore the experiences and challenges for residential care home staff when managing the healthcare needs of their residents, in particular those living with dementia. BACKGROUND: Increasing number of older people, with complex health and social care needs are living in residential care homes. Yet there is limited appreciation of why staff sometimes struggle to manage residents' healthcare needs, or understanding of their working relationship with district nurses (DNs), whose responsibility it is to provide nursing support...
February 15, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29443923/on-the-comparison-of-wearable-sensor-data-fusion-to-a-single-sensor-machine-learning-technique-in-fall-detection
#17
Panagiotis Tsinganos, Athanassios Skodras
In the context of the ageing global population, researchers and scientists have tried to find solutions to many challenges faced by older people. Falls, the leading cause of injury among elderly, are usually severe enough to require immediate medical attention; thus, their detection is of primary importance. To this effect, many fall detection systems that utilize wearable and ambient sensors have been proposed. In this study, we compare three newly proposed data fusion schemes that have been applied in human activity recognition and fall detection...
February 14, 2018: Sensors
https://www.readbyqxmd.com/read/29441773/-advantages-and-application-prospects-of-deep-learning-in-image-recognition-and-bone-age-assessment
#18
REVIEW
T H Hu, L Wan, T A Liu, M W Wang, T Chen, Y H Wang
Deep learning and neural network models have been new research directions and hot issues in the fields of machine learning and artificial intelligence in recent years. Deep learning has made a breakthrough in the applications of image and speech recognitions, and also has been extensively used in the fields of face recognition and information retrieval because of its special superiority. Bone X-ray images express different variations in black-white-gray gradations, which have image features of black and white contrasts and level differences...
December 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29436344/challenges-in-assessing-combined-interventions-to-promote-linear-growth
#19
Emily L Deichsel, Kirkby D Tickell, Jessica E Long, Nelson L Jumbe, Ali Rowhani-Rahbar, Judd L Walson
Despite the recognition of stunting as a public health priority, nutritional and nonnutritional interventions to reduce or prevent linear growth failure have demonstrated minimal impact. Investigators and policymakers face several challenges that limit their ability to assess the potential benefits of combining available interventions into a linear growth promotion package. We use two common but very different interventions, deworming and multiple micronutrient supplements, to illustrate barriers to recommending an optimal linear growth promotion package based on the currently available literature...
February 12, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29433552/chimeric-antigen-receptor-t-cell-car-t-immunotherapy-for-solid-tumors-lessons-learned-and-strategies-for-moving-forward
#20
REVIEW
Jian Li, Wenwen Li, Kejia Huang, Yang Zhang, Gary Kupfer, Qi Zhao
Recently, the US Food and Drug Administration (FDA) approved the first chimeric antigen receptor T cell (CAR-T) therapy for the treatment CD19-positive B cell acute lymphoblastic leukemia. While CAR-T has achieved remarkable success in the treatment of hematopoietic malignancies, whether it can benefit solid tumor patients to the same extent is still uncertain. Even though hundreds of clinical trials are undergoing exploring a variety of tumor-associated antigens (TAA), no such antigen with comparable properties like CD19 has yet been identified regarding solid tumors CAR-T immunotherapy...
February 13, 2018: Journal of Hematology & Oncology
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