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Ovarian cancer treatment summary

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https://www.readbyqxmd.com/read/28103826/tracking-the-origin-of-simultaneous-endometrial-and-ovarian-cancer-by-next-generation-sequencing-a-case-report
#1
Nadejda Valtcheva, Franziska M Lang, Aurelia Noske, Eleftherios P Samartzis, Anna-Maria Schmidt, Elisa Bellini, Daniel Fink, Holger Moch, Markus Rechsteiner, Konstantin J Dedes, Peter J Wild
BACKGROUND: Endometrioid adenocarcinoma of the uterus and ovarian endometrioid carcinoma share many morphological and molecular features. Differentiation between simultaneous primary carcinomas and ovarian metastases of an endometrial cancer may be very challenging but is essential for prognostic and therapeutic considerations. CASE PRESENTATION: In the present case study of a 33 year-old patient we used targeted amplicon next-generation re-sequencing for clarifying the origin of synchronous endometrioid cancer of the corpus uteri and the left ovary...
January 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28039467/targeting-cancer-stem-cell-propagation-with-palbociclib-a-cdk4-6-inhibitor-telomerase-drives-tumor-cell-heterogeneity
#2
Gloria Bonuccelli, Maria Peiris-Pages, Bela Ozsvari, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti
In this report, we systematically examined the role of telomerase activity in lung and ovarian cancer stem cell (CSC) propagation. For this purpose, we indirectly gauged telomerase activity, by linking the hTERT-promoter to eGFP. Using lung (A549) and ovarian (SKOV3) cancer cells, transduced with the hTERT-GFP reporter, we then employed GFP-expression levels to fractionate these cell lines into GFP-high and GFP-low populations. We functionally compared the phenotype of these GFP-high and GFP-low populations...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27980217/the-association-between-copper-transporters-and-the-prognosis-of-cancer-patients-undergoing-chemotherapy-a-meta-analysis-of-literatures-and-datasets
#3
REVIEW
Si Sun, Jing Cai, Qiang Yang, Simei Zhao, Zehua Wang
Copper transporter 1 (CTR1), copper transporter 2 (CTR2), copper-transporting p-type adenosine triphosphatase 1 and 2 (ATP7A and ATP7B) are key mediators of cellular cisplatin, carboplatin and oxaliplatin accumulation. In this meta-analysis, we aimed to evaluate the relation of CTR1, CTR2, ATP7A and ATP7B to overall survival (OS), progression-free survival (PFS), disease-free survival (DFS) and treatment response (TR) of cancer patients who received chemotherapy based on published literatures, the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) datasets...
December 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27812850/generation-of-t-cell-effectors-using-tumor-cell-loaded-dendritic-cells-for-adoptive-t-cell-therapy
#4
Katerina Vavrova, Petra Vrabcova, Dominik Filipp, Jirina Bartunkova, Rudolf Horvath
Adoptive T cell transfer has been shown to be an effective method used to boost tumor-specific immune responses in several types of malignancies. In this study, we set out to optimize the ACT protocol for the experimental treatment of prostate cancer. The protocol includes a pre-stimulation step whereby T cells were primed with autologous dendritic cells loaded with the high hydrostatic pressure-treated prostate cancer cell line, LNCaP. Primed T cells were further expanded in vitro with anti-CD3/CD28 Dynabeads in the WAVE bioreactor 2/10 system and tested for cytotoxicity...
December 2016: Medical Oncology
https://www.readbyqxmd.com/read/27812204/prognostic-value-and-implication-for-chemotherapy-treatment-of-abcb1-in-epithelial-ovarian-cancer-a-meta-analysis
#5
Si Sun, Jing Cai, Qiang Yang, Yapei Zhu, Simei Zhao, Zehua Wang
BACKGROUND: Chemotherapy resistance is reported to correlate with up-regulation of anti-tumor agent transporter ABCB1 (p-gp) in epithelial ovarian cancer (EOC), but the results remain controversial. To reconcile the results, a systematic review followed by meta-analysis was performed to assess the association between high ABCB1 status or ABCB1 gene variants and overall survival (OS), progression free survival (PFS), and total response rate (TR) in patients with EOC. MATERIALS AND METHODS: Electronic searches were performed using Pubmed, EMBASE, Web of Science and Chinese Wanfang databases from January 1990 to February 2016...
2016: PloS One
https://www.readbyqxmd.com/read/27799786/synergistic-suppression-effect-on-tumor-growth-of-ovarian-cancer-by-combining-cisplatin-with-a-manganese-superoxide-dismutase-armed-oncolytic-adenovirus
#6
Shibing Wang, Jing Shu, Li Chen, Xiaopan Chen, Jianhong Zhao, Shuangshuang Li, Xiaozhou Mou, Xiangmin Tong
Gene therapy on the basis of oncolytic adenovirus is a novel approach for human cancer therapeutics. We aim to investigate whether it will synergistically reinforce their antiovarian cancer activities when the combined use of ZD55-manganese superoxide dismutase (MnSOD) and cisplatin was performed. The experiments in vitro showed that ZD55-MnSOD enhances cisplatin-induced apoptosis and causes remarkable ovarian cancer cell death. Apoptosis induction by treatment with ZD55-MnSOD and/or cisplatin was detected in SKOV-3 by apoptotic cell staining, flow cytometry, and western blot analysis...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27693324/long-non-coding-rna-tug1-regulates-ovarian-cancer-proliferation-and-metastasis-via-affecting-epithelial-mesenchymal-transition
#7
Defeng Kuang, Xiaoping Zhang, Shaofang Hua, Wei Dong, Zhiguo Li
Ovarian cancer is the fifth leading cause of cancer-related death in women worldwide, and recent studies have highlighted the role of long non-coding RNAs (lncRNAs) in cancer development. However, the role of lncRNAs in ovarian cancer is largely unclear. In this study, we focused on the taurine up-regulated gene 1 (TUG1) and examined its molecular mechanism in ovarian cancer. Here, we reported that TUG1 was up-regulated in ovarian cancer tissues and ovarian cancer cells, and TUG1 expression was positively correlated with tumor grade and FIGO stage...
September 28, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27658397/internalization-of-a-novel-huge-lectin-from-ibacus-novemdentatus-slipper-lobster-induces-apoptosis-of-mammalian-cancer-cells
#8
Y Fujii, T Fujiwara, Y Koide, I Hasan, S Sugawara, S Rajia, S M A Kawsar, D Yamamoto, D Araki, R A Kanaly, Y Ogawa, H Fujita, Y Ozeki
An N-acetyl sugar-binding lectin (termed iNoL) displaying cytotoxic activity against human cancer cells was isolated from the slipper lobster Ibacus novemdentatus (family Scyllaridae). iNoL recognized monosaccharides containing N-acetyl group, and glycoproteins (e.g., BSM) containing oligosaccharides with N-acetyl sugar. iNoL was composed of five subunits (330, 260, 200, 140, and 30 kDa), which in turn consisted of 70-, 40-, and 30-kDa polypeptides held together by disulfide bonds. Electron microscopic observations and gel permeation chromatography indicated that iNoL was a huge (500-kDa) molecule and had a polygonal structure under physiological conditions...
September 22, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27607869/evolving-paradigms-in-research-and-care-in-ovarian-cancers
#9
Beth Y Karlan, Ronald D Alvarez, Jerome F Strauss
The National Academies of Sciences, Engineering, and Medicine convened an expert committee to examine and summarize the state of the science in ovarian cancer research. An Executive Summary of the recently released report describing the key findings and specific recommendations to reduce the incidence of and morbidity and mortality from ovarian cancers is presented. Highlights include the recognition that ovarian cancer is not just one disease, but rather a constellation of distinct cancer types, some of which originate outside of the ovary...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27557390/epidemiological-overview-advances-in-diagnosis-prevention-treatment-and-management-of-epithelial-ovarian-cancer-in-mexico
#10
Dolores Gallardo-Rincón, Raquel Espinosa-Romero, Wendy Rosemary Muñoz, Roberto Mendoza-Martínez, Susana Del Villar-Álvarez, Luis Oñate-Ocaña, David Isla-Ortiz, Juan Pablo Márquez-Manríquez, Ángel Apodaca-Cruz, Abelardo Meneses-García
The epithelial ovarian cancer (EOC) has been underdiagnosed because it does not have a specific clinical presentation, and the signs and symptoms are similar to the irritable bowel syndrome and pelvic inflammatory disease. EOC is less common than breast and cervical cancer, but it is more lethal. On the whole, EOC has an early dissemination to peritoneal cavity, which delays a timely diagnosis and increases the rate of advanced diagnosed disease. The diagnosis usually surprises the women and the primary care physician...
April 2016: Salud Pública de México
https://www.readbyqxmd.com/read/27486766/loss-of-arid1a-expression-leads-to-sensitivity-to-ros-inducing-agent-elesclomol-in-gynecologic-cancer-cells
#11
Suet-Yan Kwan, Xuanjin Cheng, Yvonne T M Tsang, Jong-Sun Choi, Suet-Ying Kwan, Daisy I Izaguirre, Hoi-Shan Kwan, David M Gershenson, Kwong-Kwok Wong
Inactivating mutations in ARID1A are found in a broad spectrum of cancer types, with the highest frequency in gynecologic cancers. However, therapeutic strategies targeting ARID1A-mutant cancer cells remain limited. In this study, we aimed to identify drugs sensitivities in ARID1A-mutant cancer cell lines. By analyzing the Genomics of Drug Sensitivity in Cancer database, we found that ARID1A-mutant cancer cell lines were more sensitive to treatment with the reactive oxygen species (ROS)-inducing agent elesclomol...
August 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27458161/crosstalk-between-integrin-%C3%AE-v%C3%AE-3-and-er%C3%AE-contributes-to-thyroid-hormone-induced-proliferation-of-ovarian-cancer-cells
#12
Meng-Ti Hsieh, Le-Ming Wang, Chun A Changou, Yu-Tang Chin, Yu-Chen S H Yang, Hsuan-Yu Lai, Sheng-Yang Lee, Yung-Ning Yang, Jacqueline Whang-Peng, Leroy F Liu, Hung-Yun Lin, Shaker A Mousa, Paul J Davis
Ovarian cancer is the leading cause of death in gynecological diseases. Thyroid hormone promotes proliferation of ovarian cancer cells via cell surface receptor integrin αvβ3 that activates extracellular regulated kinase (ERK1/2). However, the mechanisms are still not fully understood. Thyroxine (T4) at a physiologic total hormone concentration (10-7 M) significantly increased proliferating cell nuclear antigen (PCNA) abundance in these cell lines, as did 3, 5, 3'-triiodo-L-thyronine (T3) at a supraphysiologic concentration...
July 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27409672/stress-induced-phosphoprotein-1-maintains-the-stability-of-jak2-in-cancer-cells
#13
Chia-Lung Tsai, Angel Chao, Shih-Ming Jung, Chi-Neu Tsai, Chiao-Yun Lin, Shun-Hua Chen, Shih-Che Sue, Tzu-Hao Wang, Hsin-Shih Wang, Chyong-Huey Lai
Overexpression of stress-induced phosphoprotein 1 (STIP1) - a co-chaperone of heat shock protein (HSP) 70/HSP90 - and activation of the JAK2-STAT3 pathway occur in several tumors. Combined treatment with a HSP90 inhibitor and a JAK2 inhibitor exert synergistic anti-cancer effects. Here, we show that STIP1 stabilizes JAK2 protein in ovarian and endometrial cancer cells. Knock-down of endogenous STIP1 decreased JAK2 and phospho-STAT3 protein levels. The N-terminal fragment of STIP1 interacts with the N-terminus of JAK2, whereas the C-terminal DP2 domain of STIP1 mediates the interaction with HSP90 and STAT3...
August 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27383326/adverse-events-risk-associated-with-angiogenesis-inhibitors-addition-to-therapy-in-ovarian-cancer-a-meta-analysis-of-randomized-controlled-trials
#14
X-J Liang, J Shen
OBJECTIVE: Inhibition of angiogenesis has been regarded as an attractive treatment strategy for advanced or recurrent ovarian cancer. We conduct this meta-analysis to investigate the risk of adverse events of special interest related to angiogenesis inhibitors (AIs) in ovarian cancer. PATIENTS AND METHODS: Databases from PubMed, Web of Science and Cochrane library up to December 2015 were searched to identify relevant studies. Eligible studies included prospective randomized controlled phase II/III clinical trials evaluating therapy with or without AIs for ovarian cancer...
June 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27322684/prame-expression-and-promoter-hypomethylation-in-epithelial-ovarian-cancer
#15
Wa Zhang, Carter J Barger, Kevin H Eng, David Klinkebiel, Petra A Link, Angela Omilian, Wiam Bshara, Kunle Odunsi, Adam R Karpf
PRAME is a cancer-testis antigen (CTA) and potential immuno-therapeutic target, but has not been well-studied in epithelial ovarian cancer (EOC) or its high grade serous (HGSC) subtype. Compared to normal ovary, PRAME expression was significantly increased most EOC, regardless of stage and grade. Interestingly, PRAME mRNA expression was associated with improved survival in the HGSC subtype. The PRAME locus was a frequent target for copy number alterations (CNA) in HGSC but most changes were heterozygous losses, indicating that elevated PRAME expression is not typically due to CNA...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27172746/positive-expression-of-insulin-like-growth-factor-1-receptor-is-associated-with-a-positive-hormone-receptor-status-in-ovarian-cancer
#16
L Q Wang, W D Zhao, X J Jiao, D L Du, Y S Liu
UNLABELLED: Summary PURPOSE: Ovarian cancer is the most deadly of all gynecologic malignancies, due in part to the diagnosis at an advanced stage caused by the deficiency of specific marks and symptoms, by the absence of reliable tests for screening, and by early detection. MATERIALS AND METHODS: Insulin-like growth factor-I (IGF-I) is known to be involved in the development and promotion of diverse examples of solid tumors including ovarian cancer...
2016: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/27141069/epithelial-ovarian-cancer-the-molecular-genetics-of-epithelial-ovarian-cancer
#17
J Krzystyniak, L Ceppi, D S Dizon, M J Birrer
BACKGROUND: Epithelial ovarian cancer (EOC) remains one of the leading causes of cancer-related deaths among women worldwide, despite gains in diagnostics and treatments made over the last three decades. Existing markers of ovarian cancer possess very limited clinical relevance highlighting the emerging need for identification of novel prognostic biomarkers as well as better predictive factors that might allow the stratification of patients who could benefit from a more targeted approach...
April 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27109096/erbb2-dependent-downregulation-of-a-pro-apoptotic-protein-perp-is-required-for-oncogenic-transformation-of-breast-epithelial-cells
#18
I A Khan, B H Yoo, O Masson, S Baron, D Corkery, G Dellaire, L D Attardi, K V Rosen
The ability of breast cancer cells to resist anoikis, apoptosis caused by detachment of the non-malignant epithelial cells from the extracellular matrix (ECM), is thought to be critical for breast tumor growth, invasion and metastasis. ErbB2, an oncoprotein that is often overproduced in breast tumors, can block breast cancer cell anoikis via mechanisms that are understood only in part. In an effort to understand them better we found that detachment of the non-malignant human breast epithelial cells from the ECM upregulates a protein Perp in these cells...
April 25, 2016: Oncogene
https://www.readbyqxmd.com/read/27064283/fak-regulates-platelet-extravasation-and-tumor-growth-after-antiangiogenic-therapy-withdrawal
#19
Monika Haemmerle, Justin Bottsford-Miller, Sunila Pradeep, Morgan L Taylor, Hyun-Jin Choi, Jean M Hansen, Heather J Dalton, Rebecca L Stone, Min Soon Cho, Alpa M Nick, Archana S Nagaraja, Tony Gutschner, Kshipra M Gharpure, Lingegowda S Mangala, Rajesha Rupaimoole, Hee Dong Han, Behrouz Zand, Guillermo N Armaiz-Pena, Sherry Y Wu, Chad V Pecot, Alan R Burns, Gabriel Lopez-Berestein, Vahid Afshar-Kharghan, Anil K Sood
Recent studies in patients with ovarian cancer suggest that tumor growth may be accelerated following cessation of antiangiogenesis therapy; however, the underlying mechanisms are not well understood. In this study, we aimed to compare the effects of therapy withdrawal to those of continuous treatment with various antiangiogenic agents. Cessation of therapy with pazopanib, bevacizumab, and the human and murine anti-VEGF antibody B20 was associated with substantial tumor growth in mouse models of ovarian cancer...
May 2, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27059733/galectin-3-induces-ovarian-cancer-cell-survival-and-chemoresistance-via-tlr4-signaling-activation
#20
Guoqing Cai, Xiangdong Ma, Biliang Chen, Yanhong Huang, Shujuan Liu, Hong Yang, Wei Zou
Paclitaxel resistance becomes common in patients with aggressive ovarian cancer and results in recurrence after conventional therapy. Galectin-3 is a multifunctional lectin associated with cell migration, cell proliferation, cell adhesion, and cell-cell interaction in tumor cells. Whether circulating galectin-3 is involved in paclitaxel resistance in ovarian cancer remains unknown. The current study investigated the effect of galectin-3 on toll-like receptor 4 (TLR4) signaling and thus paclitaxel resistance...
September 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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