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Keywords Prehospital blood produce admi...

Prehospital blood produce administration

https://read.qxmd.com/read/35968196/pre-hospital-blood-products-and-calcium-replacement-protocols-in-uk-critical-care-services-a-survey-of-current-practice
#1
JOURNAL ARTICLE
Caroline Leech, Eleri Clarke
Introduction: In the United Kingdom, prehospital blood products are increasingly carried for the early resuscitation of hypovolaemia in patients who are shocked or in cardiac arrest. There is an association between hypocalcaemia and mortality in trauma patients, but no current national guidelines on the timing or dose of calcium replacement exist. The objective of this study was to establish the availability of prehospital blood products, and the current calcium replacement protocols used by UK prehospital services...
September 2022: Resuscitation plus
https://read.qxmd.com/read/35421008/blood-component-requirements-and-erythrocyte-transfusion-and-mortality-related-to-hemoglobin-deficit-in-phase-iii-trial-of-hemoglobin-based-oxygen-carrier-hboc-201
#2
JOURNAL ARTICLE
Jonathan S Jahr, John P Williams
BACKGROUND: Hemoglobin-based oxygen carriers (HBOCs) may cause coagulopathy, changes in total hemoglobin (THb), and affect mortality. Low total hemoglobin concentrations [THb] during hemorrhage may worsen outcomes. STUDY QUESTION: The database of the Hemopure HEM-0115 phase III trial was queried to determine the use of platelets, plasma, or cryoprecipitate and compare transfusion requirements and coagulation studies between patients randomized to erythrocyte transfusion or HBOC-201 infusion...
April 14, 2022: American Journal of Therapeutics
https://read.qxmd.com/read/31743300/should-albumin-be-considered-for-prehospital-resuscitation-in-austere-environments-a-prospective-randomized-survival-study-in-rabbits
#3
RANDOMIZED CONTROLLED TRIAL
Bijan S Kheirabadi, Nahir Miranda, Irasema B Terrazas, Amber N Voelker, Rodolfo de Guzman, Nathan A Wienandt, Ammon W Brown, Michael A Dubick
BACKGROUND: The new guidelines for prehospital care of combat casualties in shock recommend administration of whole blood or blood components to increase blood pressure to a permissible hypotensive level (i.e., hypotensive resuscitation [HR]). We investigated if 2 h of HR using limited volumes of whole blood, plasma, or albumin would lead to full recovery and long-term survival of rabbits subjected to severe hemorrhagic shock (HS). METHODS: Following instrumentation, laparotomy was performed on IV-anesthetized spontaneously breathing New Zealand white rabbits (3...
September 2020: Shock
https://read.qxmd.com/read/30443975/single-donor-spray-dried-plasma
#4
COMPARATIVE STUDY
Qiyong Peter Liu, Ryan Carney, Jihae Sohn, Sruthi Sundaram, Mary-Anne Fell
BACKGROUND: Dried plasma is logistically superior for hemostasis management because it can be transported and stored under nonfrozen conditions and quickly reconstituted at the point of care, enabling prehospital administration. Velico Medical has developed a spray-drying system to be integrated into routine blood center work streams for spray drying single donor plasma units. This study compared the quality of the spray-dried plasma (on-demand plasma [ODP]) with fresh frozen plasma (FFP)...
February 2019: Transfusion
https://read.qxmd.com/read/27779578/does-small-volume-resuscitation-with-crystalloids-or-colloids-influence-hemostasis-and-survival-of-rabbits-subjected-to-lethal-uncontrolled-hemorrhage
#5
JOURNAL ARTICLE
Bijan Shams Kheirabadi, Nahir Miranda, Irasema B Terrazas, Mary D Gonzales, Rose C Grimm, Michael A Dubick
BACKGROUND: Prehospital, small-volume resuscitation of combat casualties with a synthetic colloid (6% hydroxyethyl starch [HES] 670/0.75) has been recommended when blood or blood components are unavailable. We studied hemostatic effects of a newer synthetic colloid (6% HES, 130/0.4) compared with either a natural colloid (albumin) or to crystalloids in an uncontrolled hemorrhage model. METHODS: Spontaneously breathing New Zealand white rabbits (3.4 ± 0.1 kg) were anesthetized, instrumented, and subjected to a splenic injury with uncontrolled bleeding...
January 2017: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/22624697/analgesia-effect-of-a-fixed-nitrous-oxide-oxygen-mixture-on-burn-dressing-pain-study-protocol-for-a-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Li Yuxiang, Tang Lu, Yu Jianqiang, Dai Xiuying, Zhou Wanfang, Zhang Wannian, Hu Xiaoyan, Xiao Shichu, Ni Wen, Ma Xiuqiang, Wu Yinsheng, Yao Ming, Mu Guoxia, Wang Guangyi, Han Wenjun, Xia Zhaofan, Tang Hongtai, Zhao Jijun
BACKGROUND: Procedural burn pain is the most intense acute pain and most likely type of burn injury pain to be undertreated due to the physician's fear of the adverse effect of analgesia and lack of anesthetist present. At our institution, in most of the cases, local burn detersion and debridement were performed at the ward level without any analgesics. This article describes a study designed to test the analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain. METHODS/DESIGN: The experiment was carried out in three centers...
May 24, 2012: Trials
https://read.qxmd.com/read/22251191/root-causes-of-errors-in-a-simulated-prehospital-pediatric-emergency
#7
JOURNAL ARTICLE
Richard Lammers, Maria Byrwa, William Fales
OBJECTIVES: Systematic evaluation of prehospital provider performance during actual resuscitations is difficult. Although prior studies reported pediatric drug-dosing mistakes and other types of management errors, the underlying causes of those errors were not investigated. The objective of this study was to identify causes of errors during a simulated, prehospital pediatric emergency. METHODS: Two-person emergency medical services (EMS) crews from five geographically diverse agencies participated in a validated simulation of an infant with altered mental status, seizures, and respiratory arrest using their own equipment and drugs...
January 2012: Academic Emergency Medicine
https://read.qxmd.com/read/20466829/inhaled-methoxyflurane-and-intranasal-fentanyl-for-prehospital-management-of-visceral-pain-in-an-australian-ambulance-service
#8
COMPARATIVE STUDY
Steven Johnston, Garry J Wilkes, Jennifer A Thompson, Mel Ziman, Richard Brightwell
OBJECTIVE: This study analysed the analgesic effect and changes in vital signs associated with administration of inhaled Methoxyflurane (MTX) and/or intranasal Fentanyl (INF) for prehospital management of visceral pain. METHOD: A retrospective, observational study reviewing 1024 randomly selected records of patients with presumed visceral pain administered MTX (465), INF (397) or both (162) by the Western Australian Ambulance Service between January 2004 and February 2006...
January 2011: Emergency Medicine Journal: EMJ
https://read.qxmd.com/read/18813168/surgery-of-cerebral-trauma-and-associated-critical-care
#9
REVIEW
Alex B Valadka, Claudia S Robertson
The last 30 years have been both exciting and frustrating for those in the field of traumatic brain injury (TBI). Much has been learned, but no new treatment has been shown to improve patient outcomes despite the execution of many clinical trials. The overall incidence of TBI has decreased, probably because of intensive efforts toward prevention and education. Rigorous assessment of available research has produced several evidence-based guidelines for the management of neurotrauma patients. The creation of organized emergency medical services systems in many regions has improved prehospital care...
July 2007: Neurosurgery
https://read.qxmd.com/read/1949938/the-dose-of-epinephrine-during-cardiopulmonary-resuscitation-in-humans-what-should-it-be
#10
REVIEW
E R Gonzalez, J P Ornato
The objective of vasopressor therapy during closed-chest cardiopulmonary resuscitation (CPR) is to augment coronary perfusion pressure so that spontaneous circulation can be reestablished. Epinephrine, an endogenous catecholamine with both alpha- and beta-adrenergic activity, is the vasopressor of choice for use during CPR. Epinephrine's potent alpha1-and alpha2-adrenergic effects improve cerebral and myocardial blood flow by preventing arterial collapse and by increasing peripheral vasoconstriction. The optimal dose of epinephrine in humans during closed-chest CPR is unknown...
July 1991: DICP: the Annals of Pharmacotherapy
https://read.qxmd.com/read/1688751/hypertonic-saline-resuscitation-saturated-salt-dextran-solutions-are-equally-effective-but-induce-hemolysis-in-dogs
#11
JOURNAL ARTICLE
M Rocha e Silva, I T Velasco, M F Porfirio
Hypertonic saline, or saline-dextran resuscitation is normally achieved with an Na+ load of 4.8 to 7.2 mEq/kg given in a small volume (typically 4 to 6 ml/kg NaCl 7.5%). Na+ can also be administered saturated in a smaller volume, e.g., 1 to 1.5 ml/kg NaCl 25%, with similar results. Such reduction in administered volume would be an asset in prehospital trauma management. In the present experiments, severely bled (45 ml/kg) dogs were treated with one of three NaCl/dextran-70 solutions: S1, 25% NaCl + 24% dextran (1...
February 1990: Critical Care Medicine
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