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https://www.readbyqxmd.com/read/28440264/use-of-testicular-sperm-for-intracytoplasmic-sperm-injection-in-men-with-high-sperm-dna-fragmentation-a-swot-analysis
#1
Sandro C Esteves, Matheus Roque, Nicolás Garrido
Spermatozoa retrieved from the testis of men with high levels of sperm DNA fragmentation (SDF) in the neat semen tend to have better DNA quality. Given the negative impact of SDF on the outcomes of Assisted Reproductive Technology (ART), an increased interest has emerged about the use of testicular sperm for intracytoplasmic sperm injection (Testi-ICSI). In this article, we used a SWOT (strengths, weaknesses, opportunities, and threats) analysis to summarize the advantages and drawbacks of this intervention...
April 18, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28435790/a-rare-case-of-epididymal-abscess-in-an-infant-treated-successfully-with-needle-aspiration
#2
Hidenori Nishio, Kentaro Mizuno, Taiki Kato, Yoshinobu Moritoki, Hideyuki Kamisawa, Satoshi Kurokawa, Akihiro Nakane, Atsushi Okada, Takahiro Yasui, Yutaro Hayashi
A 5-month-old boy presented with right scrotal swelling. Color Doppler ultrasonography showed an encapsulated hypoechoic lesion with surrounding hyperemia in the right tail of the epididymis. We performed surgical exploration of the scrotum because it was not considered to be a typical epididymitis. During the operation, we aspirated pus from his right epididymis through a needle by referring to the color Doppler findings. This is the first case of epididymal abscess in an infant to be successfully diagnosed and treated with needle aspiration...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28431577/dichloroacetic-acid-induced-testicular-toxicity-in-male-rats-and-the-protective-effect-of-date-fruit-extract
#3
Amira El Arem, Lamia Lahouar, Emna Behija Saafi, Amira Thouri, Fatma Ghrairi, Zohra Houas, Fadoua Neffati, Lotfi Achour
BACKGROUND: The present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats. METHODS: Forty-eight male Wistar rats were randomly divided into six groups of eight: group I served as the control; group II was given ADE (4 ml/kg) by gavage; groups III and IV received DCA at 0.5 and 2 g/L drinking water, respectively; and groups V and VI received DCA at 0.5 and 2 g/L drinking water, respectively, before ADE administration...
April 22, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28428445/pectinase-treated-panax-ginseng-protects-heat-stress-induced-testicular-damage-in-rats
#4
Min Kyoung Kim, Kyu-Min Cha, Seock-Yeon Hwang, Un-Kyu Park, Seok Kyo Seo, Sang-Ho Lee, Min-Sik Jeong, SiHyun Cho, Spandana Rajendra Kopalli, Si-Kwan Kim
Testicular hyperthermia is well studied to cause impaired spermatogenesis. In the present study, the protective effect of enzymatically modified (pectinase-treated) Panax ginseng (GINST) against intermittent sub-chronic heat stress-induced testicular damage in rats was investigated. Male Sprague-Dawley rats were divided into four groups: normal control (NC), heat-stressed control (HC), heat-stressed plus GINST-100 mg/kg/day (HG100) and heat-stressed plus GINST-200 mg/kg/day (HG200) treatment groups. GINST (100 and 200 mg/kg/day) was mixed separately with a regular pellet diet and was administered orally for 8 weeks starting from 1 week before heat exposure...
June 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28421491/chapter-7-human-epididymal-and-testicular-sperm-cryopreservation
#5
Pankaj Talwar, Sarabpreet Singh
Since the advent of intracytoplasmic sperm injection (ICSI) in the early 1990s, surgical techniques to recover samples from the epididymis and testis directly have been used to benefit patients suffering from obstructive and nonobstructive azoospermia. Various studies have demonstrated comparable fertilization, ongoing pregnancy, and implantation rates when fresh and frozen-thawed epididymal sperms were used for ICSI [1]. Injection of fresh and frozen testicular sperms into mature oocytes resulted in similar fertilization rates in cases of obstructive azoospermia...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28418343/the-use-of-human-epididymis-4-and-cancer-antigen-125-tumor-markers-in-the-benign-or-malignant-differential-diagnosis-of-pelvic-or-adnexal-masses
#6
Zehra Nihal Dolgun, Canan Kabaca, Ateş Karateke, Cem İyibozkurt, Cihan İnan, Ahmet Salih Altıntaş, Cihan Karadağ
BACKGROUND: Ovarian cancer is one of the highest mortality cancers in gynaecology. Discrimination of benign masses from malignant ones may sometimes become a challenge for the clinician since there is not a reliable tumour marker, thus some unnecessary, highly morbid operations can be performed. AIMS: To explore the efficacy of human epididymis 4 (HE 4) and cancer antigen 125 (CA 125) markers in differentiating malignant and benign pelvic masses of ovarian origin and to identify the cut-off points for those markers...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28410062/role-of-imaging-in-the-evaluation-of-male-infertility
#7
Pardeep K Mittal, Brent Little, Peter A Harri, Frank H Miller, Lauren F Alexander, Bobby Kalb, Juan C Camacho, Viraj Master, Matthew Hartman, Courtney C Moreno
Infertility is defined herein as the inability to achieve pregnancy after frequently engaging in unprotected sexual intercourse for 1 year. Among infertile couples, the cause of infertility involves the male partner in approximately 50% of cases. Male infertility is usually caused by conditions affecting sperm production, sperm function, or both, or blockages that prevent the delivery of sperm. Chronic health problems, injuries, lifestyle choices, anatomic problems, hormonal imbalances, and genetic defects can have a role in male infertility...
April 14, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28406844/the-role-of-he4-a-novel-biomarker-in-predicting-optimal-cytoreduction-after-neoadjuvant-chemotherapy-in-advanced-ovarian-cancer
#8
Francesco Plotti, Giuseppe Scaletta, Stella Capriglione, Roberto Montera, Daniela Luvero, Salvatore Lopez, Alessandra Gatti, Carlo De Cicco Nardone, Corrado Terranova, Roberto Angioli
OBJECTIVES: This study aimed to evaluate serum human epididymis protein 4 (HE4) changes during neoadjuvant chemotherapy (NACT) to establish HE4 predebulking surgery cutoff values and to demonstrate that CA125, HE4, and computed tomography (CT) taken together are better able to predict complete cytoreduction after NACT in advanced ovarian cancer patients. METHODS: From January 2006 to November 2015, patients affected by epithelial advanced ovarian cancer (International Federation of Gynecology and Obstetrics stage III-IV), considered not optimally resectable, were included in this prospective study...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28404209/investigation-of-toxoplasma-gondii-in-semen-testicle-and-epididymis-tissues-of-primo-infected-cats-felis-catus
#9
Weslen Fabricio Pires Teixeira, Maria Eduarda Gonçalves Tozato, Julia Cestari Pierucci, Giovana Pavão Vital, André Cayeiro Cruz, Welber Daniel Zanetti Lopes, Marina Suzuki Cursino, Samea Fernandes Joaquim, Vando Edésio Soares, Helio Langoni, Kátia Denise Saraiva Bresciani, Alvimar José da Costa
This study aimed to investigate the presence of Toxoplasma gondii in semen, testicle and epididymis tissues of cats experimentally infected by this coccidium. A total of 12 male felines without a definite breed that were of reproductive age and serologically negative for T. gondii were selected and distributed to the following three experimental groups: GI, inoculated with 600 tissue cysts of the P strain of T. gondii (isolate III); GII, inoculated with 2×10(5) tachyzoites of the RH strain (isolate I); and GIII, not inoculated (control group)...
April 3, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28403740/bisphenol-a-induces-oxidative-stress-in-bone-marrow-cells-lymphocytes-and-reproductive-organs-of-holtzman-rats
#10
Dinesh Tiwari, Geeta Vanage
Bisphenol A (BPA) is an estrogenic chemical used in the production of polycarbonate plastics and epoxy resins. Our earlier studies have demonstrated that BPA is a potent reproductive and genotoxic agent and affects the normal physiological functions. The objective of this study was to evaluate whether exposure to BPA induces oxidative stress. The male Holtzman rats were orally gavaged with BPA (0.01 mg and 5.0 mg/kg/bw) over the period of 6 days. Animals were euthanized by cervical dislocation at the end of the treatments; bone marrow cells and blood lymphocytes were aspirated; testis and epididymis were collected, immediately frozen in liquid nitrogen, and stored at -80°C...
March 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28395327/developmental-expression-of-the-dynamin-family-of-mechanoenzymes-in-the-mouse-epididymis%C3%A2
#11
Wei Zhou, Geoffry N De Iuliis, Adrian P Turner, Andrew T Reid, Amanda L Anderson, Adam McCluskey, Eileen A McLaughlin, Brett Nixon
The mammalian epididymis is an exceptionally long ductal system tasked with the provision of one of the most complex intraluminal fluids found in any exocrine gland. This specialized milieu is continuously modified by the combined secretory and absorptive of the surrounding epithelium and thus finely tuned for its essential roles in promoting sperm maturation and storage. While considerable effort has been focused on defining the composition of the epididymal fluid, relatively less is known about the intracellular trafficking machinery that regulates this luminal environment...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28395326/signaling-mechanisms-in-mammalian-sperm-motility%C3%A2
#12
Maria João Freitas, Srinivasan Vijayaraghavan, Margarida Fardilha
The goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in the epididymis and hyperactivated motility in the female reproductive tract. Motility is only achieved when the sperm presents a fully functional flagellum, is capable of producing energy to fuel the movement, and suffers epididymal maturation and capacitation. Since sperm is a transcriptionally silent cell, motility depends on the activation and/or inhibitions of key signaling pathways. This review describes and discusses the main signaling pathways involved in primary and hyperactivated motility, as well as the bioenergetic mechanisms necessary to produce energy to fuel sperm motility...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28390185/the-non-peptide-vasopressin-v1b-receptor-antagonist-ssr149415-ameliorates-spermatogenesis-function-in-a-mouse-model-of-chronic-social-defeat-stress
#13
Bin Wang, Jian Zhou, Yan-Yan Zhuang, Liang-Liang Wang, Jin-Xian Pu, Yu-Hua Huang, Fei Xia, Jin-Xing Lv
To determine the effects of SSR149415 on testis and spermatogenesis in male mice subjected to chronic social defeat stress, C57BL/6 male mice were divided into 2 groups: Control and Stress. Then Stress group was subdivided into 4 subgroups administered water, SSR149415 (1 mg/kg/day), SSR149415 (10 mg/kg/day), SSR149415 (30 mg/kg/day), respectively. The behavioral alterations revealed by social interaction test and open field test were measured. The physical indices, including body weight and gonad weight (testis and epididymis) as well as testis/body weight and cauda epididymis/body weight were detected...
April 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28385522/transcriptome-analysis-of-the-effects-of-chitosan-on-the-hyperlipidemia-and-oxidative-stress-in-high-fat-diet-fed-mice
#14
Bin Wang, Sicong Zhang, Xiaoya Wang, Shuo Yang, Qixing Jiang, Yanshun Xu, Wenshui Xia
Transcriptome analysis was performed to investigate the alterations in gene expression after chitosan (CS) treatment on the liver of mice fed with high-fat diet (HFD). The results showed that the body weight, the liver weight and the epididymal fat mass of HFD mice, which were 62.98%, 46.51% and 239.37%, respectively, higher than those of control mice, could be significantly decreased by chitosan supplementation. Also, high-fat diet increased both plasma lipid and liver lipid as compared with the control mice...
April 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28385395/cytoplasmic-droplet-acting-as-a-mitochondrial-modulator-during-sperm-maturation-in-dogs
#15
D S R Angrimani, J D A Losano, C F Lucio, G A L Veiga, F C Landim, M Nichi, C I Vannucchi
Motility acquisition during sperm maturation and passage through the epididymis is closely related to mitochondrial function and appears to occur in parallel with cytoplasmic droplet (CD) migration. However, such mechanism remains unclear in dogs. Thus, the aim of this study was to characterize the influence of sperm CD in the mitochondrial functionality during epididymal sperm maturation in dogs. Twenty-one adult dogs were submitted to elective bilateral orchiectomy. Testicles were stored for 18-24h at 5°C and epididymal sperm samples were then collected from different segments of the epididymis (caput, corpus and cauda)...
March 30, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28384194/loss-of-slc9a3-decreases-cftr-protein-and-causes-obstructed-azoospermia-in-mice
#16
Ya-Yun Wang, Ying-Hung Lin, Yi-No Wu, Yen-Lin Chen, Yung-Chih Lin, Chiao-Yin Cheng, Han-Sun Chiang
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF) and are associated with congenital bilateral absence of the vas deferens (CBAVD), which is the major cause of infertility in male patients with CF. However, most Taiwanese patients with CBAVD do not carry major CFTR mutations. Some patients have a single copy deletion of the solute carrier family 9 isoform 3 (SLC9A3) gene. SLC9A3 is a Na+/H+ exchanger, and depleted Slc9a3 in male mice causes infertility due to the abnormal dilated lumen of the rete testis and efferent ductules...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28379507/impact-of-male-fertility-status-on-the-transcriptome-of-the-bovine-epididymis
#17
Christine Légaré, Ayodélé Akintayo, Patrick Blondin, Ezequiel Calvo, Robert Sullivan
STUDY QUESTION: Can region-specific transcriptional profiling of the epididymis from fertile and sub-fertile bulls predict the etiology of fertility/sub-fertility in males? SUMMARY ANSWER: The highly regulated gene expression along the bovine epididymis is affected by the fertility status of bulls used for artificial insemination. WHAT IS KNOWN ALREADY: In mammals, sperm maturation and storage occur in the epididymis. Each epididymal segment has his own transcriptomic signature that modulates the intraluminal composition and consequently governs sequential modifications of the maturing male gamete...
April 3, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28379345/epididymal-cyp2e1-plays-a-critical-role-in-acrylamide-induced-dna-damage-in-spermatozoa-and-paternally-mediated-embryonic-resorptions
#18
A L Katen, P Sipila, L A Mitchell, S J Stanger, B Nixon, S D Roman
Acrylamide is a ubiquitous toxicant in human lives, due to its formation in many food products. Acrylamide induces dominant lethal mutations with administration of 25 mg/kg bw/day for 5 days in male mice. Cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1) is responsible for this dominant lethality. CYP2E1 is the only enzyme responsible for the conversion of acrylamide to the highly reactive metabolite glycidamide, which forms adduct with DNA. CYP2E1 is present predominantly in the liver, as well as the brain, kidney, intestines and spleen...
March 31, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28376793/comparative-genomic-identification-and-validation-of-%C3%AE-defensin-genes-in-the-ovis-aries-genome
#19
T J Hall, C McQuillan, E K Finlay, C O'Farrelly, S Fair, K G Meade
BACKGROUND: β-defensins are small, cationic, antimicrobial peptides found in species across the plant and animal kingdoms. In addition to microbiocidal activity, roles in immunity as well as reproduction have more recently been documented. β-defensin genes in Ovis aries (domestic sheep) have been poorly annotated, having been identified only by automatic gene prediction algorithms. The objective of this study was to use a comparative genomics approach to identify and characterise the β-defensin gene repertoire in sheep using the bovine genome as the primary reference...
April 4, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28376772/different-expression-of-b7-h3-in-the-caput-corpus-and-cauda-of-the-epididymis-in-mouse
#20
Kai Li, Xuedong Wei, Guangbo Zhang, Miao Li, Xuefeng Zhang, Chenhao Zhou, Jianquan Hou, Hexing Yuan
BACKGROUND: B7-H3, a member of the B7 family of the Ig superfamily of proteins, has been detected in the epididymis, which is a storage organ related to sperm maturation. However, the characteristics of its expression in different regions of the epididymis remain unknown. Our aim was to investigate the expression of B7-H3 in the caput, corpus, and cauda of the epididymis. METHODS: We extracted epididymis specimens from adult male C57BL/6 mice. The expression of B7-H3 was then measured with immunohistochemistry, enzyme-linked immunosorbent assay (ELISA) and western blotting...
April 4, 2017: BMC Urology
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