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https://www.readbyqxmd.com/read/28314792/comparative-profiling-of-small-rnas-of-pig-seminal-plasma-and-ejaculated-and-epididymal-sperm
#1
Cai Chen, Han Wu, Dan Shen, Saisai Wang, Li Zhang, Xiaoyan Wang, Bo Gao, Tianwen Wu, Bichun Li, Kui Li, Chengyi Song
The similarities and differences of small RNAs in seminal plasma, epididymal sperm and ejaculated sperm remain largely undefined. We conducted a systematic comparative analysis of small RNA profiles in pig ejaculated sperm, epididymal sperm and seminal plasma and found that the diversity distribution of small RNA species was generally similar, whereas the abundance of small RNAs is dramatically different across the three libraries; miRNAs and small RNAs derived from rRNA, tRNA, small nuclear RNA, 7SK RNA, NRON RNA and cis-regulatory RNA were enriched in the three libraries, but piRNA was absent...
March 17, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28300557/high-fat-diet-aggravates-2-2-4-4-tetrabromodiphenyl-ether-inhibited-testosterone-production-via-dax-1-in-leydig-cells-in-rats
#2
Zhan Zhang, Yongquan Yu, Hengsen Xu, Chao Wang, Minghui Ji, Jun Gu, Lu Yang, Jiansheng Zhu, Huibin Dong, Shou-Lin Wang
Growing evidence has revealed that a high-fat diet (HFD) could lead to disorders of glycolipid metabolism and insulin-resistant states, and HFDs have been associated with the inhibition of testicular steroidogenesis. Our previous study demonstrated that 2,2',4,4'-tetrabromodiphenyl ether (BDE47) could increase the risk of diabetes in humans and reduce testosterone production in rats. However, whether the HFD affects BDE47-inhibited testosterone production by elevating insulin levels and inducing related pathways remains unknown...
March 11, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28298247/tissue-specific-inhibition-of-urokinase-type-plasminogen-activator-expression-in-the-testes-of-mice-by-inducible-lentiviral-rna-interference-causes-male-infertility
#3
Kai Zhao, Yan Liu, Zhe Xiong, Lian Hu, Cheng-Liang Xiong
Urokinase-type plasminogen activator (uPA) is involved in many physiological processes, including male infertility. To explore the effects of uPA in male reproduction, we constructed an inducible uPA short hairpin RNA (shRNA) system expressed by lentiviral vectors. After proving inhibition of uPA expression in the mouse Sertoli cell line TM4 by 1μgmL-1 doxycycline (Dox), two lentivirus (pLenti4-shRNA and pLenti6/TR) were co-microinjected into mouse testes to produce TetR&shuPA mice model. Though oral gavage by 0...
March 16, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28297559/molecular-changes-and-signaling-events-occurring-in-spermatozoa-during-epididymal-maturation
#4
REVIEW
M G Gervasi, P E Visconti
After leaving the testis, spermatozoa have not yet acquired the ability to move progressively and are unable to fertilize oocytes. To become fertilization competent, they must go through an epididymal maturation process in the male, and capacitation in the female tract. Epididymal maturation can be defined as those changes occurring to spermatozoa in the epididymis that render the spermatozoa the ability to capacitate in the female tract. As part of this process, sperm cells undergo a series of biochemical and physiological changes that require incorporation of new molecules derived from the epididymal epithelium, as well as post-translational modifications of endogenous proteins synthesized during spermiogenesis in the testis...
March 2017: Andrology
https://www.readbyqxmd.com/read/28292009/selenium-and-a-newly-synthesized-thiocyanoacetamide-reduce-doxorubicin-gonadotoxicity-in-male-rat
#5
Marwa Boussada, Ridha Ben Ali, Azaa Ben Said, Khouloud Bokri, Azaiez Ben Akacha, Chedli Dziri, Michèle Véronique El May
Despite its deleterious effect on healthy cells and highly regenerating cells such as spermatozoa, Doxorubicin (DOX) is still one of the most used anticancer drugs in the last decades. The present work aimed to investigate the ability of the selenium (Se) and the thiocyanoacetamide (T) to reduce DOX toxicity in gonad. Adult male rats were treated with DOX intravenously (i.v.) at 3.7mg/kg/week associated with Se intragastrically (i.g.) at 0.2mg/kg/day or with T at 10mg/kg/day i.g. After 47days of treatment, sperm quality, biochemical parameters, blood cell count and histological changes in liver, testis and epididymis were assessed...
March 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28289609/the-regenerative-effect-of-bone-marrow-derived-stem-cells-in-spermatogenesis-of-infertile-hamster
#6
Akbar Vahdati, Alireza Fathi, Mehrdokht Hajihoseini, Ghaem Aliborzi, Ebrahim Hosseini
BACKGROUND: Infertility is a serious social problem in advanced nations, with male factor in half of all cases of infertility. This study was conducted to determine the regenerative effect of bone marrow-derived stem cells in spermatogenesis of infertile hamster. METHODS: Twelve adult male hamsters were equally divided into azoospermic and control groups. Busulfan was intraperitoneally used for induction of azoospermia, while the right testis was treated with bone marrow-derived stem cells (10(6) BM-SCs), labeled with sterile trypan blue, 35 days after busulfan injection...
January 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28283003/bacterial-magnetic-particles-improve-testes-mediated-transgene-efficiency-in-mice
#7
COMPARATIVE STUDY
Chao Wang, Guanghong Sun, Ye Wang, Nana Kong, Yafei Chi, Leilei Yang, Qiliang Xin, Zhen Teng, Xu Wang, Yujun Wen, Ying Li, Guoliang Xia
Nano-scaled materials have been proved to be ideal DNA carriers for transgene. Bacterial magnetic particles (BMPs) help to reduce the toxicity of polyethylenimine (PEI), an efficient gene-transferring agent, and assist tissue transgene ex vivo. Here, the effectiveness of the BMP-PEI complex-conjugated foreign DNAs (BPDs) in promoting testes-mediated gene transfer (TMGT) in mouse was compared with that of liposome-conjugated foreign DNAs. The results proved that through testes injection, the clusters of BPDs successfully reached the cytoplasm and the nuclear of spermatogenesis cell, and expressed in testes of transgene founder mice...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28280799/investigating-the-effects-of-citrullus-colocynthis-pulp-on-oxidative-stress-in-testes-and-epididymis-in-streptozotocin-induced-diabetic-male-rats
#8
Fereshteh Ostovan, Ali Gol, Abdolreza Javadi
BACKGROUND: Diabetes mellitus is one of the most common metabolic diseases in humans, affecting 100 million people around the world. OBJECTIVE: Investigating the effects of Citrullus colocynthis pulp on oxidant and antioxidant factors of testes and epididymis in streptozotocin-induced diabetic male rats. MATERIALS AND METHODS: Thirty two male rats were divided into four groups (n=8) 1) N (normal) group, 2) N+C group, 3) D (diabetic) group and 4) D+C group...
January 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28263131/factors-and-practice-patterns-that-affect-the-decision-for-vasoepididymostomy
#9
Kevin A Ostrowski, Nicholas N Tadros, A Scott Polackwich, R Dale McClure, Eugene F Fuchs, Jason C Hedges
INTRODUCTION: To determine the factors used to make the decision between vasovasostomy (VV) and vasoepididymostomy (VE) by leaders performing microsurgical vasectomy reversal using a questionnaire. MATERIALS AND METHODS: An online questionnaire was sent to all members of the Society for the Study of Male Reproduction (SSMR), a male reproduction subspecialty society of the AUA, using the SurveyMonkey platform. RESULTS: Sixty-seven surgeons responded to the questionnaire (27% of SSMR members)...
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28261763/effects-of-selenium-nanoparticles-on-reproductive-performance-of-male-sprague-dawley-rats-at-supranutritional-and-nonlethal-levels
#10
Lujie Liu, Yudan He, Zhiping Xiao, Wenjing Tao, Jia Zhu, Bin Wang, Zixun Liu, Minqi Wang
This research investigated the influence of selenium nanoparticles (SeNPs) on the reproductive performance of male Sprague-Dawley (SD) rats. A suspension of SeNPs was consecutively administered by oral gavage for 2 weeks at supranutritional (0.2, 0.4, or 0.8 mg Se/kg bw) and nonlethal (2.0, 4.0, or 8.0 mg Se/kg bw) levels to male SD rats. The normal control (NC) rats were exposed to physiological saline alone. Biochemical parameters, sperm motility, gene expression of GPx1 and GPx4, and histopathological evaluation of male spermary were measured in this work...
March 6, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28254160/how-does-a-viviparous-semifossorial-lizard-reproduce-ophiodes-intermedius-squamata-anguidae-from-subtropical-climate-in-the-wet-chaco-region-of-argentina
#11
Martín A Ortiz, Jorgelina M Boretto, Nora R Ibargüengoytía
The best predictors of reproductive patterns are commonly associated with climate factors, but evolutionary history also plays an important role. The semifossorial and viviparous lizard Ophiodes intermedius from the Wet Chaco region of Argentina showed an annual cycle with asynchrony between males and females and an unusual pattern for subtropical climates, with vitellogenesis beginning in autumn, ovulation and copulation in spring, and births occurring in summer. Males exhibited annual variation of testicular size associated with spermatogenic activity, reaching their maximum gonadal activity in late summer (March), but sperm storage in the epididymis and/or deferent duct occurred throughout the year...
January 16, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28245889/comparison-of-different-extenders-on-the-recovery-and-longevity-of-epididymal-sperm-from-spix-s-yellow-toothed-cavies-galea-spixii-wagler-1831
#12
Andréia Maria da Silva, Patrícia Cunha Sousa, Lívia Batista Campos, José Artur Brilhante Bezerra, Arthur Emannuel de Araújo Lago, Moacir Franco de Oliveira, Alexandre Rodrigues Silva
The aim of this study was to evaluate the performance of cavy (Galea spixii) epididymal sperm following addition to TES or TRIS extenders and using a thermal resistance test (TRT), as well as fluorescence analysis as a complementary method to predict the viability of these gametes. Nine testicle-epididymis complexes were used for sperm collection using a flotation method. Epididymis tails were sliced and one was immersed in 3 ml of TRIS buffer, and the other in 3 ml of TES, for 5 min. After sperm recovery, the samples were subjected to a TRT which involved incubation in a water bath at 37°C for 3 h...
March 1, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28242287/chronic-administration-of-gabapentin-and-a-gabapentin-carbamazepine-combination-reversibly-suppress-testicular-function-in-male-wistar-rats-rattus-norvegicus
#13
Opeyemi Samson Osuntokun, Gbola Olayiwola, Ayowole Oladele, Idowu Ola, Oludele AyokaAbiodun
The effect of chronic administration of gabapentin, carbamazepine or a gabapentin-carbamazepine combination on testicular function in male rats was investigated to determine the effect of combining reduced doses of anti-epileptic drugs on the management of seizures, particularly with respect to the testis sequellae of chronic anti-epileptic administration. Male rats were randomized into four groups (n=10). Each group received daily intraperitoneal (i.p.) injections for 28days as follows: Group I, normal saline 0...
February 13, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28242272/estrogen-dependent-extrahepatic-synthesis-of-vitellogenin-in-male-vertebrates-a-mini-review
#14
Mariailaria Verderame, Rosaria Scudiero
In the last years, the hormonal balance is threatened by the interferences of substances with hormone-like action (endocrine disruptor chemicals, EDCs) that may harm animal reproduction. Most EDCs are resistant to environmental degradation and are considered ubiquitous contaminants. EDCs may have synthetic or natural origins. Pesticides used in intensive agriculture contain large amounts of chemicals with estrogenic properties, such as the alkylphenol nonylphenol (NP). Besides, animal feeding operations are important sources of natural estrogen metabolites introduced into the environment through manure application in organic farming...
February 24, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28239673/effectiveness-of-a-walnut-enriched-diet-on-murine-sperm-involvement-of-reduced-peroxidative-damage
#15
Lauren S Coffua, Patricia A Martin-DeLeon
A walnut supplement for a Western-style diet in men was shown to improve sperm motility, vitality, and morphology. To gain further insights into factors underlying this improvement, we administered a parallel walnut-enriched diet to mice [including those with a defect in sperm motility due to deletion of Plasma Membrane Ca(2+)-ATPase 4 (Pmca4(-/-) )] to determine if there is a similar improvement that is accompanied by reduced sperm membrane peroxidative damage. Although sperm vitality and acrosome reaction rate were unaffected, the diet led to a significant improvement in motility (P < 0...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28238445/pentoxifylline-effects-on-capacitation-and-fertility-of-stallion-epididymal-sperm
#16
P N Guasti, G A Monteiro, R R D Maziero, M T Carmo, J A Dell'Aqua, A M Crespilho, E A Rifai, F O Papa
The aims of this study were to determinate whether pentoxifylline (PTX) increases the motion parameters of fresh and frozen-thawed equine epididymal spermatozoa, to evaluate the tyrosine phosphorylation of frozen-thawed epididymal sperm in the presence of PTX and to determine whether the PTX-treatment of stallion epididymal sperm prior to freezing improves the fertility response of mares to a reduced number of spermatozoa per insemination dose. Fifty epididymis were flushed with a skim milk based extender with or without PTX...
April 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28237871/assessment-of-serum-he4-levels-throughout-the-normal-menstrual-cycle
#17
Richard G Moore, Beth Plante, Erin Hartnett, Jessica Mitchel, Christine A Raker, Wendy Vitek, Elizabeth Eklund, Geralyn Lambert-Messerlian
BACKGROUND: Human Epididymis Protein 4 (HE4) is a serum biomarker to aid in differentiating benign and malignant disease in women with a pelvic mass. Interpretation of HE4 results relies on robust normative data. OBJECTIVES: The purpose of this study was to evaluate whether HE4 levels are variable in women during the normal menstrual cycle. STUDY DESIGN: Healthy women, ages 18-45 years, with regular menstrual cycles were recruited from community gynecological practices in Rhode Island...
February 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28235483/effect-of-lipid-metabolism-on-male-fertility
#18
Namhyo Kim, Hitomi Nakamura, Hidetake Masaki, Keiichi Kumasawa, Ken-Ichi Hirano, Tadashi Kimura
Cholesterol and lipid homeostasis is important for male fecundity. However, the plasma total cholesterol level does not reflect sperm concentration and motility. Adipose tissue in mammals is the main tissue contributing to the dynamic equilibrium of lipid synthesis and catabolism. However, recent studies suggested that local lipolysis has an important role in male fertility. If so, which plasma lipid metabolism parameter reflects sperm concentration and motility? Leptin receptor-deficient db/db mice show hyperphagia, hyperglycemia, hypercholesterolemia, hypertriglyceridemia, morbid obesity and are reported to be infertile...
April 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28229966/extra-oviductal-expression-of-oviductal-glycoprotein-1-in-mouse-detection-in-testis-epididymis-and-ovary
#19
Saniya Laheri, Deepak Modi, Purvi Bhatt
Oviductal glycoprotein 1 (OVGP1), also called oviductin, is an oviduct-specific protein and is suggested to play a role in fertilization. Traditionally, Ovgp1 has been shown to be exclusively expressed by the oviduct; however, recent studies have demonstrated its expression in some cancers. This observation led us to hypothesize that Ovgp1 might have some extra-oviductal expression. In the current study, we evaluated the mRNA and protein expression of Ovgp1 in normal reproductive tissues of male and female mice...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28218038/postoperative-human-epididymis-protein-4-predicts-primary-therapy-outcome-in-advanced-epithelial-ovarian-cancer
#20
Tuulia Vallius, Johanna Hynninen, Annika Auranen, Jaakko Matomäki, Sinikka Oksa, Pia Roering, Seija Grènman
Primary chemotherapy treatment response monitoring in advanced epithelial ovarian cancer (EOC) is currently based on CT-imaging and serum CA125 values. Serum HE4 profile during first line chemotherapy has not been previously studied. We evaluated the HE4 profile during first line chemotherapy after primary (PDS) and interval debulking surgery (IDS). In total, 49 FIGO stage III/IV EOC patients were included in the study. 22 patients underwent PDS and 27 patients neoadjuvant chemotherapy (NACT) followed by IDS...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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