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Epididymis

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https://www.readbyqxmd.com/read/28934517/human-epididymis-protein-4-as-a-potential-biomarker-of-chronic-kidney-disease-in-female-patients-with-normal-ovarian-function
#1
Tengfei Yuan, Yan Li
Background: Elevated serum concentrations of human epididymis protein 4 (HE4) have appeared in a large number of female patients with chronic kidney disease (CKD). However, it is unknow whether HE4 could be a potential biomarker for diagnosis of CKD. Objective: To evaluate whether serum HE4 is a potential biomarker of CKD in our cohort of 238 ethnic Han Chinese female patients, between the ages of 19 and 89 years. Methods: We selected 230 healthy control individuals and 238 female patients with CKD for inclusion in our study...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28928542/developmental-contribution-of-wnt-signal-responsive-cells-to-mouse-reproductive-tract-formation
#2
Ryuma Haraguchi, Riko Kitazawa, Aki Murashima, Gen Yamada, Sohei Kitazawa
In mammals, the müllerian duct (MD) is an embryonic tubular structure that gives rise to the female reproductive tract (FRT). The MD originates from the coelomic epithelium (CoE) and takes on a rostral to caudal shape to establish the primary structure of the FRT under the regulation of morphogenetic signals. During these developmental processes, the MD and its derivatives require proper regulation of the Wnt-signaling-pathway. Here, to investigate the developmental contribution of FRT primordia under the influence of the Wnt-signaling, genetic lineage tracing was carried out using TopCreER/Rosa-LacZ mice to follow the fate of Wnt-signal-responsive cells during reproductive tract formation...
August 25, 2017: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/28928083/preparation-and-characterization-of-a-high-affinity-monoclonal-antibody-against-human-epididymis-protein-4
#3
Yunlong Shen, Yuxi Wang, Xiaohua Jiang, Liang Lu, Chengdi Wang, Wenxin Luo, Yongxia Zhang, Pei Li, Zhengwei Du, Tengfei Dai, Congcong Wu, Aiping Fang, Yuqin Yao, Qian Peng, Jinliang Yang
Human epididymis protein-4 (HE4) may serve as a putative biomarker for the early diagnosis, therapy and especially prognosis of ovarian, lung and breast cancer. Detection and targeting of HE4 using the anti-HE4 antibody could be one of the effective strategies for the cancer diagnosis and treatment in clinical practice. In this study, a high-efficiency expression system was established to purify recombinant HE4. We obtained high purity HE4 in 400 mg quantity from 1 L culture supernatant of HEK293F cells. CCK-8 and cell cycle assays indicated that the purified recombinant HE4 protein could promote SKOV3 cell cycle and proliferation at the concentration of 0...
September 16, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28927238/factor-v-leiden-is-associated-with-increased-sperm-count
#4
T E van Mens, U N Joensen, Z Bochdanovits, A Takizawa, J Peter, N Jørgensen, P B Szecsi, J C M Meijers, H Weiler, E Rajpert-De Meyts, S Repping, S Middeldorp
STUDY QUESTION: Is the thrombophilia mutation factor V Leiden (FVL) associated with an increased total sperm count? SUMMARY ANSWER: Carriers of FVL have a higher total sperm count than non-FVL-carriers, which could not be explained by genetic linkage or by observations in a FVL-mouse model. WHAT IS KNOWN ALREADY: FVL has a high prevalence in Caucasians despite detrimental health effects. Carriers have been shown to have higher fecundity, which might partly explain this evolutionary paradox...
September 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28925477/the-study-on-the-effect-of-hyperglycemia-on-offspring-fatty-tissue-metabolism-during-pregnancy
#5
H-P Dong, M-Z Tan, Q-J Liu, J Wang, S-B Zhong
OBJECTIVE: In this study, we adopted maternal diabetes model on rats, which induced by streptozotocin to explore the metabolism changes of rat adipose tissue during the neonatal period. MATERIALS AND METHODS: The female rats were induced as diabetes models by streptozotocin (STZ), and mated with the normal male rats when they entered into adulthood. The chosen male offspring rats were executed at week 12 and the epididymis and subcutaneous fat pad were obtained...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28918527/alterations-in-epididymal-proteomics-and-antioxidant-activity-of-mice-exposed-to-fluoride
#6
Zilong Sun, Sujuan Li, Yuxiang Yu, Hongyu Chen, Mohammad Mehdi Ommati, Ram Kumar Manthari, Ruiyan Niu, Jundong Wang
It is well known that high fluoride results in low fertility. Epididymis is the important place for spermatozoa maturation, which is essential for successful fertilization. In the previous studies, fluoride was reported to damage the epididymal structure of mouse and rabbit. However, the mechanism underlying sodium fluoride (NaF)-induced epididymal toxicity has not yet been well elucidated. The aim of this study is to explore the global protein alterations in epididymis of mice exposed to NaF using the iTRAQ technique...
September 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28915635/dysregulation-of-an-x-linked-primate-specific-epididymal-microrna-cluster-in-unexplained-asthenozoospermia
#7
Xingrong Qing, Jian Shi, Tingting Dong, Chunlin Wu, Lian Hu, Honggang Li
Asthenoszoopermia, characterized by reduced sperm motility, is one of the primary forms of male infertility. Whereas most cases were diagnosed into unexplained asthenozoospermia (UA) because the etiology cannot be identified. In animal models, epigenetic dysregulation in epididymis can impair sperm maturation and result in asthenozoospermia. However, researches of epididymal epigenetic regulation on humans are impeded by the difficulty in obtaining epididymal tissues. We previously identified cell-free seminal microRNAs predominately derived from epididymis in human ejaculate...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28911169/obesity-induced-infertility-in-male-mice-is-associated-with-disruption-of-crisp4-expression-and-sperm-fertilization-capacity
#8
Beatriz C Borges, David Garcia-Galiano, Sanseray da Silveira Cruz-Machado, Xingfa Han, Galina B Gavrilina, Thomas L Saunders, Richard J Auchus, Saher S Hammoud, Gary D Smith, Carol F Elias
Approximately 15% of human couples of reproductive age have impaired fertility, and the male component accounts for about half of these cases. The etiology is usually unknown, but high correlation with the increase in obesity rates is documented. In this study, we show that diet-induced and genetically obese mice display copulatory behavior comparable to controls, but the number of females impregnated by obese males is remarkably low. Screening for changes in gene expression in the male reproductive tract showed decreased Crisp4 expression in testis and epididymis of obese mice...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28904906/a-step-by-step-guide-to-office-based-sperm-retrieval-for-obstructive-azoospermia
#9
REVIEW
Robert M Coward, Jesse N Mills
A variety of surgical options exists for sperm retrieval in the setting of obstructive azoospermia (OA). With appropriate preparation, the majority of these techniques can safely be performed in the office with local anesthesia and with or without monitored anesthesia care (MAC). The available techniques include percutaneous options such as percutaneous epididymal sperm aspiration (PESA) and testicular sperm aspiration (TESA), as well as open techniques that include testicular sperm extraction (TESE) and microsurgical epididymal sperm aspiration (MESA)...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28902733/131i-whole-body-scan-incidental-uptake-due-to-spermatocele
#10
Domenico Albano, Federica Motta, Carla Baronchelli, Silvia Lucchini, Francesco Bertagna
A 46-year-old man with papillary thyroid cancer post total thyroidectomy was referred for post radioiodine (I) whole-body scan. Whole-body images revealed intense I uptake in the bed thyroid and a focal abnormal uptake in the testicular area. Subsequent SPECT/CT demonstrated that the focal uptake corresponded to the left epididymis, and the pathology report revealed a spermatocele with no immunohistochemical features for thyroid tissue. Many cases of unexpected radioiodine uptake have been reported, and spermatocele could be counted for another possibility of incidental I uptake despite an unclear mechanism...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28894584/serum-human-epididymis-protein-4-levels-in-colorectal-cancer-patients
#11
Yasemi N Kemal, Guzi N Demirag, Abdulkeri M Bedir, Leman Tomak, Murat Derebey, Di Lek Erdem, Ufuk Gör, Idris Yücel
Tumour markers are widely used for the diagnosis, staging and monitoring of colorectal cancer (CRC) patients in clinical practice. Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are the most frequently used biomarkers in CRC patients. A number of studies have recently investigated the presence of human epididymis protein 4 (HE4) overexpression in certain cancer types. Its significance in ovarian and endometrial cancer has been well-demonstrated. The aim of the present study was to evaluate the significance of serum HE4 levels in CRC patients...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28893024/diagnostic-performance-of-serum-human-epididymis-protein-4-in-endometrial-carcinoma-a-pilot-study
#12
Rupali Dewan, Abhinav Dewan, Swati Hare, Mausumi Bhardwaj, Krati Mehrotra
INTRODUCTION: Endometrial Cancer (EC) is a common female malignant disorder. To date, there are no specific tumour markers for EC that may be routinely used in clinical practice for diagnosis. AIM: To evaluate the diagnostic performance of the serum Human Epididymis protein 4 (HE4) as biomarker for EC and to determine its association with clinicopathological variables. MATERIALS AND METHODS: The study population included 60 postmenopausal women with a diagnosis of EC and 60 healthy postmenopausal female subjects (control group)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28887675/how-bad-is-aluminum-exposure-to-reproductive-parameters-in-rats
#13
Viviane G S Mouro, Tatiana P Menezes, Graziela D A Lima, Rafael R Domingues, Ana Cláudia F Souza, Juraci A Oliveira, Sérgio L P Matta, Mariana Machado-Neves
Aluminum (Al) is the most widely distributed metal in the environment and is extensively used in human daily life without any known biological function. It is known that exposure to high concentrations of Al impacts negatively on serum testosterone levels, testicular histomorphometry, and sperm parameters; however, no information is available about the effects of low exposure levels on reproduction. International organizations have established the Al concentration tolerated in drinking water as 3.35 × 10(-4) mg/kg...
September 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28885334/potential-association-between-elevated-serum-human-epididymis-protein-4-and-renal-fibrosis-a-systemic-review-and-meta-analysis
#14
Peipei Chen, Qiao Yang, Xuemei Li, Yan Qin
BACKGROUND: Human epididymis protein 4 (HE4), a matrix metalloprotease 2 (MMP2), and a matrix metalloprotease 9 (MMP9) inhibitor, promotes renal fibrosis by inhibiting the degradation of type I collagen. However, the predictive value of HE4 for renal fibrosis remains controversial, even though it has been identified as one of the most upregulated genes in cultured fibrosis-associated myofibroblasts. This systematic review and meta-analysis was conducted to investigate the potential association between circulating HE4 and renal fibrosis...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28884241/torsed-appendix-epididymis-in-an-adult-misdiagnosis-as-tumor-of-tunica-vaginalis-on-sonography
#15
Dal Mo Yang, Hyun Cheol Kim, Sang Won Kim, Ji Su Kim, Kyu Yeoun Won
We report the sonographic findings in a case of torsed appendix epididymis that occurred in an adult, which was misdiagnosed as a tunica vaginalis tumor such as cystic mesothelioma. Scrotal gray-scale sonography revealed an ovoid-shaped, heterogeneously hypoechoic mass with multiple tiny cystic foci and thick septa in the sac of the right tunica vaginalis, which abuts to the right epididymal head. Color Doppler sonography showed no blood flow within the mass. Pathological examination revealed torsion of the appendix epididymis...
September 7, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28879095/unilateral-complete-agenesis-of-mesonephric-duct-derivatives-in-an-82-year-old-male-cadaver-embryology-anatomy-and-clinical-considerations
#16
David G Darcy, Morgen Yao-Cohen, Todd R Olson, Sherry A Downie
Development of urogenital anatomy in the human fetus is the result of a complex interplay between multiple different tissues. The time course of development is well documented and the morphologic outcomes of insults at various time points during development are predictable. We present a cadaveric case of unilateral agenesis of the left kidney, ureter, bladder hemitrigone, ureteric opening, seminal vesicle, vas deferens, and epididymis. Failure of development of the mesonephric duct early during embryogenesis, likely between the third and fifth week, caused ipsilateral urogenital organ agenesis...
November 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28870888/cell-secreted-vesicles-containing-micrornas-as-regulators-of-gamete-maturation
#17
Juliano C da Silveira, Ana Clara F C M de Avila, Hannah L Garrett, Jason Bruemmer, Quinton Winger, Gerrit Bouma
Mammalian gamete maturation requires extensive signaling between germ cells and their surrounding somatic cells. In the ovary, theca cells, mural granulosa cells, cumulus cells and the oocyte all secrete factors throughout follicle growth and maturation that are critical for ovulation of a high quality oocyte with the competence to develop into an embryo. Similarly, maturation of sperm occurs as it transits the epididymis during which epididymal epithelium and sperm exchange secretory factors that are required for sperm to gain motility and fertility...
September 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28869875/ultrastructure-and-morphometric-features-of-epididymal-epithelium-in-desmodus-rotundus
#18
Mariana Moraes de Castro, Wagner Gonzaga Gonçalves, Stéphanie Asséf Millen Valente Teixeira, Maria do Carmo Queiroz Fialho, Felipe Couto Santos, Jerusa Maria Oliveira, José Eduardo Serrão, Mariana Machado-Neves
The blood-feeding behavior of Desmodus rotundus made this bat a potential vector of rabies virus and a public health issue. Consequently, the better understanding of its reproductive biology becomes valuable for the development of methods to control its population. In this study, we described morphological aspects of epithelial cells in D. rotundus' epididymis using light and transmission electron microscopy methods. The duct compartment was the main component of initial segment (83%), caput (90%), corpus (88%) and cauda (80%) regions...
August 26, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28869169/-temocillin-and-urinary-tract-infections
#19
M Vallée, F Bruyère, F Roblot, L Brureau
INTRODUCTION: Temocillin is an alternative to treat urinary tract infections with bacteria producing extended spectrum beta-lactamase (ESBL). The objective is to evaluate the use of temocillin in urinary tract infections. MATERIALS AND METHODS: A systematic review of literature was carried out according to PRISMA criteria. All national and international recommendations have been reviewed regarding the indication of the use of temocillin in urology. Data collection on the use of temocillin in urinary tract infection has been performed from the Cochrane, LILACS and the Medline database...
August 28, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28865222/evaluation-of-intra-testicular-injections-of-calcium-chloride-and-4-vinylcyclohexene-1-2-monoepoxide-for-chemical-sterilization-in-guinea-pigs
#20
C C Sen, N Yumusak, R Faundez, F Temamogullari, A Taskin
This study was aimed at investigating the use of intra-testicular calcium chloride (CaCl2) and 4-vinylcyclohexene 1,2-monoepoxide (VCM) injections as a side effect-free alternative method for the control of reproduction in guinea pigs. Fifty male guinea pigs were randomly assigned to five groups. In all groups, the chemical agents were injected into both testes in 1% lidocaine hydrochloride. While Groups I, II and III were administered with a single dose (0.25 mL) of sterile physiological saline, 15 mg/100 g CaCl2, and 240 mg/kg VCM, respectively, Group IV and V received a daily dose of 15 mg/100 g CaCl2, and 240 mg/kg VCM for 3 days, respectively...
March 1, 2017: Polish Journal of Veterinary Sciences
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