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https://www.readbyqxmd.com/read/28441796/role-of-dietary-crocin-in-in-vivo-melanoma-tumor-remission
#1
Hamid A Bakshi, Faruck Lukmanul Hakkim, Smitha Sam, Farideh Javid
Background: Melanoma is a deadly form of malignancy. Early diagnosis might pave the way to cure but its aggressive nature leads to rapid dissemination and colonization of distant organs. Dietary herbs may play a significant role in prevention of cancer. In this study, we tested anti-tumor efficacy of the Crocus sativus derived active constituent crocin, well established to have anti-cancer properties in different cancer models by our group and other groups and other groups. Notably, crocin is reported to exert anti-proliferative effect on melanoma cells (B16F10) in vitro...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441763/improving-passive-time-reversal-underwater-acoustic-communications-using-subarray-processing
#2
Chengbing He, Lianyou Jing, Rui Xi, Qinyuan Li, Qunfei Zhang
Multichannel receivers are usually employed in high-rate underwater acoustic communication to achieve spatial diversity. In the context of multichannel underwater acoustic communications, passive time reversal (TR) combined with a single-channel adaptive decision feedback equalizer (TR-DFE) is a low-complexity solution to achieve both spatial and temporal focusing. In this paper, we present a novel receiver structure to combine passive time reversal with a low-order multichannel adaptive decision feedback equalizer (TR-MC-DFE) to improve the performance of the conventional TR-DFE...
April 24, 2017: Sensors
https://www.readbyqxmd.com/read/28441751/implementation-issues-of-adaptive-energy-detection-in-heterogeneous-wireless-networks
#3
Iker Sobron, Iñaki Eizmendi, Wallace A Martins, Paulo S R Diniz, Juan Luis Ordiales, Manuel Velez
Spectrum sensing (SS) enables the coexistence of non-coordinated heterogeneous wireless systems operating in the same band. Due to its computational simplicity, energy detection (ED) technique has been widespread employed in SS applications; nonetheless, the conventional ED may be unreliable under environmental impairments, justifying the use of ED-based variants. Assessing ED algorithms from theoretical and simulation viewpoints relies on several assumptions and simplifications which, eventually, lead to conclusions that do not necessarily meet the requirements imposed by real propagation environments...
April 23, 2017: Sensors
https://www.readbyqxmd.com/read/28441743/smartphone-location-independent-physical-activity-recognition-based-on-transportation-natural-vibration-analysis
#4
Taeho Hur, Jaehun Bang, Dohyeong Kim, Oresti Banos, Sungyoung Lee
Activity recognition through smartphones has been proposed for a variety of applications. The orientation of the smartphone has a significant effect on the recognition accuracy; thus, researchers generally propose using features invariant to orientation or displacement to achieve this goal. However, those features reduce the capability of the recognition system to differentiate among some specific commuting activities (e.g., bus and subway) that normally involve similar postures. In this work, we recognize those activities by analyzing the vibrations of the vehicle in which the user is traveling...
April 23, 2017: Sensors
https://www.readbyqxmd.com/read/28441740/a-miniature-aerosol-sensor-for-detecting-polydisperse-airborne-ultrafine-particles
#5
Chao Zhang, Dingqu Wang, Rong Zhu, Wenming Yang, Peng Jiang
Counting and sizing of polydisperse airborne nanoparticles have attracted most attentions owing to increasing widespread presence of airborne engineered nanoparticles or ultrafine particles. Here we report a miniature aerosol sensor to detect particle size distribution of polydisperse ultrafine particles based on ion diffusion charging and electrical detection. The aerosol sensor comprises a couple of planar electrodes printed on two circuit boards assembled in parallel, where charging, precipitation and measurement sections are integrated into one chip, which can detect aerosol particle size in of 30-500 nm, number concentration in range of 5 × 10²-10⁷ /cm³...
April 22, 2017: Sensors
https://www.readbyqxmd.com/read/28441739/the-use-of-immus-in-a-water-environment-instrument-validation-and-application-of-3d-multi-body-kinematic-analysis-in-medicine-and-sport
#6
Anna Lisa Mangia, Matteo Cortesi, Silvia Fantozzi, Andrea Giovanardi, Davide Borra, Giorgio Gatta
The aims of the present study were the instrumental validation of inertial-magnetic measurements units (IMMUs) in water, and the description of their use in clinical and sports aquatic applications applying customized 3D multi-body models. Firstly, several tests were performed to map the magnetic field in the swimming pool and to identify the best volume for experimental test acquisition with a mean dynamic orientation error lower than 5°. Successively, the gait and the swimming analyses were explored in terms of spatiotemporal and joint kinematics variables...
April 22, 2017: Sensors
https://www.readbyqxmd.com/read/28441722/experimental-demonstration-and-circuitry-for-a-very-compact-coil-only-pulse-echo-emat
#7
Dirk Rueter
This experimental study demonstrates for the first time a solid-state circuitry and design for a simple compact copper coil (without an additional bulky permanent magnet or bulky electromagnet) as a contactless electromagnetic acoustic transducer (EMAT) for pulse echo operation at MHz frequencies. A pulsed ultrasound emission into a metallic test object is electromagnetically excited by an intense MHz burst at up to 500 A through the 0.15 mm filaments of the transducer. Immediately thereafter, a smoother and quasi "DC-like" current of 100 A is applied for about 1 ms and allows an echo detection...
April 22, 2017: Sensors
https://www.readbyqxmd.com/read/28441680/magnetic-resonance-imaging-safety-of-magnetically-controlled-growing-rods-in-an-in-vivo-animal-model
#8
Mehmet Eroglu, Gokhan Demirkiran, Ismail Aykut Kocyigit, Hasan Bilgili, Mehmet Burak Kaynar, Ali Bumin, Sadan Ozcan, Muharrem Yazici
STUDY DESIGN: Experimental animal study. OBJECTIVE: To investigate the interaction between magnetically controlled growing rods (MCGRs) and magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND DATA: Growing rod treatment through serial operations results in adverse effects on the patient and high treatment costs. MCGRs can be lengthened noninvasively in an outpatient setting and with lower treatment costs. When MRI investigation is required, the interaction between MCGRs and MRI is an issue of concern in patients with MCGRs...
May 1, 2017: Spine
https://www.readbyqxmd.com/read/28441675/teaching-today-in-the-practice-setting-of-the-future-implementing-innovations-in-graduate-medical-education
#9
Jung G Kim, Carl G Morris, Paul Ford
PROBLEM: Implementing an innovation, such as offering new types of patient-physician encounters through the patient-centered medical home (PCMH) model while maintaining Accreditation Council for Graduate Medical Education (ACGME) accreditation standards (e.g., patient encounter minimums for trainees), is challenging. APPROACH: In 2009, the Group Health Family Medicine Residency (GHFMR) received an ACGME Program Experimentation and Innovation Project (PEIP) exception that redefined the minimum Family Medicine Resident Review Committee requirement to 1,400 face-to-face visits and 250 electronic visits (1 electronic visit defined as 3 secure message or telephone encounters)...
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441601/improving-understanding-of-mixed-land-use-watershed-suspended-sediment-regimes-mechanistic-progress-through-high-frequency-sampling
#10
Elliott Kellner, Jason A Hubbart
Given the importance of suspended sediment to biogeochemical functioning of aquatic ecosystems, and the increasing concern of mixed-land-use effects on pollutant loading, there is an urgent need for research that quantitatively characterizes spatiotemporal variation of suspended sediment dynamics in contemporary watersheds. A study was conducted in a representative watershed of the central United States utilizing a nested-scale experimental watershed design, including five gauging sites (n=5) partitioning the catchment into five sub-watersheds...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441594/cotransport-of-human-adenoviruses-with-clay-colloids-and-tio2-nanoparticles-in-saturated-porous-media-effect-of-flow-velocity
#11
Vasiliki I Syngouna, Constantinos V Chrysikopoulos, Petros Kokkinos, Maria A Tselepi, Apostolos Vantarakis
This study focuses on the effects of two clay colloids (kaolinite, KGa-1b and montmorillonite, STx-1b) and titanium dioxide (TiO2) nanoparticles (NPs) on human adenovirus transport and retention in water saturated porous media at three different pore water velocities (0.38, 0.74, and 1.21cm/min). Transport and cotransport experiments were performed in 30-cm long laboratory columns packed with clean glass beads with 2mm diameter. The experimental results suggested that the presence of KGa-1b, STx-1b and TiO2 NPs increased human adenovirus inactivation and attachment onto the solid matrix, due to the additional attachment sites available...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441543/simultaneous-electrochemiluminescence-determination-of-galanthamine-homolycorine-lycorenine-and-tazettine-in-lycoris-radiata-by-capillary-electrophoresis-with-ultrasonic-assisted-extraction
#12
Shuangjiao Sun, Yanfen Wei, Yupin Cao, Biyang Deng
After ultrasonic-assisted extraction, four lycoris radiata alkaloids: galanthamine, homolycorine, lycorenine, and tazettine were determined by capillary electrophoresis electrochemiluminescence. Polyvinylpyrrolidone was added to the running buffer (RB) to obtain better resolution. Experimental conditions influencing the determination were examined, including the additives, detection potential, separation voltage, injection voltage and time, and RB pH and concentration. Under optimal experimental conditions, the baseline separation of the four alkaloids occurred within 16min...
April 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28441540/supramolecular-interaction-of-methotrexate-with-cucurbit-7-uril-and-analytical-application
#13
Yin-Xia Chang, Xiang-Mei Zhang, Xue-Chao Duan, Fan Liu, Li-Ming Du
The supramolecular interaction between cucurbit[7]uril (CB[7]) as the host and the anti-cancer drug methotrexate (MTX) as the guest was studied using fluorescence spectroscopy, UV-visible absorption spectroscopy, (1)H NMR, 2D NOESY, and theoretical calculations. The experimental results confirmed the formation of 1:2 inclusion complex with CB[7] and indicated a simple and sensitive competitive method for the fluorescence detection of MTX. It was found that the fluorescence intensities of CB[7]-palmatine, CB[7]-berberine and CB[7]-coptisine were quenched linearly upon the addition of MTX...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28441539/a-quantum-chemical-insight-into-the-tunable-fluorescence-color-and-distinct-photoisomerization-mechanisms-between-a-novel-esipt-fluorophore-and-its-protonated-form
#14
Huijuan Yuan, Songyan Feng, Keke Wen, Qiuling Zhu, Beibei An, Xugeng Guo, Jinglai Zhang
Enol-keto proton tautomerization and cis-trans isomerization reactions of a novel excited-state intramolecular proton transfer (ESIPT) fluorophore of BTImP and its protonated form (BTImP(+)) were explored using density functional theory/time-dependent density functional theory (DFT/TD-DFT) computational methods with a B3LYP hybrid functional and the 6-31+G(d,p) basis set. In addition, the absorption and fluorescence spectra were calculated at the TD-B3LYP/6-31+G(d,p) level of theory. Our results reveal that both BTImP and BTImP(+) can undergo an ultrafast ESIPT reaction, giving rise to the single fluorescence emission with different fluorescence colors, which are nicely consistent with the experimental findings...
April 19, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28441519/grounding-principles-for-inferring-agency-two-cultural-perspectives
#15
Bethany L Ojalehto, Douglas L Medin, Salino G García
The present research investigates cultural variation in grounding principles for inferring agency in order to address an important theoretical debate: does cultural diversity in agency concepts reflect an animistic overextension of (universal) folkpsychology, as many have argued, or an alternative theory of folkcommunication based on relational principles? In two experiments, mind perception measures were adapted to assess beliefs concerning the agency of non-animal kinds (plants, abiotic kinds, complex artifacts) among Indigenous Ngöbe adults in Panama and US college students...
April 22, 2017: Cognitive Psychology
https://www.readbyqxmd.com/read/28441502/differential-coupling-of-binding-atp-hydrolysis-and-transport-of-fluorescent-probes-with-p-glycoprotein-in-lipid-nanodiscs
#16
Mavis Jiarong Li, Abhinav Nath, William M Atkins
The ATP-binding cassette transporter P-glycoprotein (ABCB1) plays a major role in cellular resistance to drugs, and drug interactions. Experimental studies support a mechanism with nucleotide-dependent fluctuation between inward-facing and outward-facing conformations, which are coupled to nucleotide hydrolysis. However, detailed insight into drug-dependent modulation of these conformational ensembles is lacking. Different drugs likely occupy partially overlapping but distinct sites, and are therefore variably coupled to nucleotide binding and hydrolysis...
April 25, 2017: Biochemistry
https://www.readbyqxmd.com/read/28441496/room-temperature-ferromagnetism-in-2d-fe2si-nanosheet-with-enhanced-spin-polarization-ratio
#17
Yingjie Sun, Zhiwen Zhuo, Xiaojun Wu, Jinlong Yang
Searching experimental feasible two-dimensional (2D) ferromagnetic crystals with large spin-polarization ratio, high Curie temperature and large magnetic anisotropic energy is one key to develop next-generation spintronic nano-devices. Here, 2D Fe2Si nanosheet, one counterpart of Hapkeite mineral discovered in meteorite, with novel magnetism is proposed on the basis of first-principles calculations. 2D Fe2Si crystal has a slightly buckled triangular lattice with planar hexacoordinated Si and Fe atoms. The spin-polarized calculations with hybrid HSE06 function method indicate that 2D Fe2Si is a ferromagnetic half metal at its ground state with 100% spin-polarization ratio at Fermi energy level...
April 25, 2017: Nano Letters
https://www.readbyqxmd.com/read/28441495/catalytic-directional-cutting-of-hexagonal-boron-nitride-the-roles-of-interface-and-etching-agent
#18
Liang Ma, Xiao Cheng Zeng
Transition-metal (TM) nanoparticle catalyzed cutting has been proven to be an efficient approach to carve out straight channels in graphene to produce high-quality nanoribbons. However, applicability of such a catalytic approach to hexagonal boron nitride (h-BN) is still an open question due to binary element compositions. Here, our ab initio study indicates that long/straight channels along either zigzag or armchair direction of the BN sheet can be carved out, driven by the energetically favored TM-zigzag or TM-armchair BN interface, regardless of roughness of TM particle surface...
April 25, 2017: Nano Letters
https://www.readbyqxmd.com/read/28441482/the-value-of-nmr-parameters-and-dft-calculations-for-quantum-information-processing-utilizing-phosphorus-heterocycles
#19
Jessica Boreli Dos Reis Lino, Eduardo P Rocha, Teodorico Castro Ramalho
Quantum computing is the field of science that uses quantum-mechanical phenomena, such as superposition and entanglement, to perform operations on data. The fundamental information unit used in quantum computing is the quantum bit or qubit. It is well-known that quantum computers could theoretically be able to solve problems much more quickly than any classical computers. Currently, the first and still the most successful implementations of quantum information processing (QIP) have been based on nuclear spins in liquids...
April 25, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28441481/best-practices-of-computer-aided-drug-discovery-cadd-lessons-learned-from-the-development-of-a-preclinical-candidate-for-prostate-cancer-with-a-new-mechanism-of-action
#20
Fuqiang Ban, Kush Dalal, Huifang Li, Eric LeBlanc, Paul S Rennie, Artem Cherkasov
Small-molecule drug design is a complex and iterative decision-making process relying on pre-existing knowledge and driven by experimental data. Low molecular weight chemicals represent an attractive therapeutic option as they are readily accessible to organic synthesis and can easily be characterized.1 Their potency, as well as pharmacokinetic and pharmacodynamic properties can be systematically and rationally investigated, and ultimately optimized via expert science behind medicinal chemistry and methods of computer-aided drug design (CADD)...
April 25, 2017: Journal of Chemical Information and Modeling
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