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https://www.readbyqxmd.com/read/28231625/experimental-study-on-1-25-oh-2-d3-amelioration-of-oral-lichen-planus-through-regulating-nf-%C3%AE%C2%BAb-signaling-pathway
#1
Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang
OBJECTIVE: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it. METHODS: H&E staining, myeloid Peroxidase (MPO) assays, quantitative PCR (qPCR), western blotting and Elisa were used to test the human biopsies and serum. QPCR, western blotting, Elisa and siRNA transfection were also performed in LPS-induced keratinocytes to observe the functions of vitamin D and VDR...
February 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28231616/a-dedicated-nutritional-care-program-nutricare-to-reduce-malnutrition-in-institutionalized-dysphagic-older-people-a-quasi-experimental-study
#2
Milko Zanini, Annamaria Bagnasco, Gianluca Catania, Giuseppe Aleo, Marina Sartini, Maria Luisa Cristina, Stefania Ripamonti, Fiammetta Monacelli, Patrizio Odetti, Loredana Sasso
AIMS AND OBJECTIVES: To assess the effects of a texture-modified food program for dysphagia on the nutritional, biochemical, and functional profile in a cohort of institutionalized older people in Italy. BACKGROUND: Dysphagic institutionalized older people, often also affected by dementia, are frequently exposed to malnutrition. Malnutrition in older people has negative effects on mortality, days of hospitalization, infection, wound healing, and risk of pressure injuries...
February 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28231607/position-in-the-second-stage-of-labour-for-women-with-epidural-anaesthesia
#3
REVIEW
Marion Kibuka, Jim G Thornton
BACKGROUND: Epidural analgesia for pain relief in labour prolongs the second stage of labour and results in more instrumental deliveries. It has been suggested that a more upright position of the mother during all or part of the second stage may counteract these adverse effects. This is an update of a Cochrane review first published in 2013. OBJECTIVES: To assess the effects of different birthing positions (upright and recumbent) during the second stage of labour, on important maternal and fetal outcomes for women with epidural analgesia...
February 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28231539/a-new-model-to-predict-diffusive-self-heating-during-composting-incorporating-the-reaction-engineering-approach-rea-framework
#4
Aditya Putranto, Xiao Dong Chen
During composting, self-heating may occur due to the exothermicities of the chemical and biological reactions. An accurate model for predicting maximum temperature is useful in predicting whether the phenomena would occur and to what extent it would have undergone. Elevated temperatures would lead to undesirable situations such as the release of large amount of toxic gases or sometimes would even lead to spontaneous combustion. In this paper, we report a new model for predicting the profiles of temperature, concentration of oxygen, moisture content and concentration of water vapor during composting...
February 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28231535/formic-acid-aided-hot-water-extraction-of-hemicellulose-from-european-silver-birch-betula-pendula-sawdust
#5
Werner Marcelo Goldmann, Juha Ahola, Marja Mikola, Juha Tanskanen
Hemicellulose has been extracted from birch (Betula pendula) sawdust by formic acid aided hot water extraction. The maximum amount of hemicellulose extracted was about 70mol% of the total hemicellulose content at 170°C, measured as the combined yield of xylose and furfural. Lower temperatures (130 and 140°C) favored hemicellulose hydrolysis rather than cellulose hydrolysis, even though the total hemicellulose yield was less than at 170°C. It was found that formic acid greatly increased the hydrolysis of hemicellulose to xylose and furfural at the experimental temperatures...
February 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28231517/measurements-of-x-ray-doses-and-spectra-produced-by-picosecond-laser-irradiated-solid-targets
#6
Bo Yang, Rui Qiu, Minghai Yu, Jinlong Jiao, Wei Lu, Yonghong Yan, Bo Zhang, Zhimeng Zhang, Weimin Zhou, Junli Li, Hui Zhang
Experiments have shown that high-intensity laser interaction with a solid target can generate significant X-ray doses. This study was conducted to determine the X-ray doses and spectra produced for picosecond laser-irradiated solid targets. The photon doses and X-ray spectra in the laser forward and side directions were measured using an XG III ps 300 TW laser system. For laser intensities of 7×10(18)-4×10(19)W/cm(2), the maximum photon dose was 16.8 mSv at 50cm with a laser energy of ~153J on a 1-mm Ta target...
February 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28231515/computational-tools-for-enzyme-improvement-why-everyone-can-and-should-use-them
#7
REVIEW
Maximilian Ccjc Ebert, Joelle N Pelletier
This review presents computational methods that experimentalists can readily use to create smart libraries for enzyme engineering and to obtain insights into protein-substrate complexes. Computational tools have the reputation of being hard to use and inaccurate compared to experimental methods in enzyme engineering, yet they are essential to probe datasets of ever-increasing size and complexity. In recent years, bioinformatics groups have made a huge leap forward in providing user-friendly interfaces and accurate algorithms for experimentalists...
February 20, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28231499/surfactant-cobalt-iii-complexes-the-impact-of-hydrophobicity-on-interaction-with-hsa-and-dna-insights-from-experimental-and-theoretical-approach
#8
Selvakumar Veeralakshmi, Gopal Sabapathi, Selvan Nehru, Ponnambalam Venuvanalingam, Sankaralingam Arunachalam
To develop surfactant-based metallodrugs, it is very important to know about their hydrophobicity, micelle forming capacity, their interaction with biomacromolecules such as proteins and nucleic acids, and biological activities. Here, diethylenetriamine (dien) and tetradecylamine ligand (TA) based surfactant-cobalt(III) complexes with single chain domain, [Co(dien)(TA)Cl2]ClO4 (1) and double chain domain [Co(dien)(TA)2Cl](ClO4)2 (2) were chosen to study the effect of hydrophobicity on the interaction with human serum albumin and calf thymus DNA...
February 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28231496/attrition-in-trials-evaluating-complex-interventions-for-schizophrenia-systematic-review-and-meta-analysis
#9
REVIEW
P Szymczynska, S Walsh, L Greenberg, S Priebe
Essential criteria for the methodological quality and validity of randomized controlled trials are the drop-out rates from both the experimental intervention and the study as a whole. This systematic review and meta-analysis assessed these drop-out rates in non-pharmacological schizophrenia trials. A systematic literature search was used to identify relevant trials with ≥100 sample size and to extract the drop-out data. The rates of drop-out from the experimental intervention and study were calculated with meta-analysis of proportions...
February 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28231486/coded-excitation-waveform-engineering-for-high-frame-rate-synthetic-aperture-ultrasound-imaging
#10
Bahman Lashkari, Kaicheng Zhang, Edem Dovlo, Andreas Mandelis
Coded excitation was initially introduced to ultrasound imaging as a method for enhancing the signal-to-noise ratio (SNR). However, this method was also shown to be helpful in conjunction with synthetic aperture transmission for high frame rate imaging. Recently, we introduced two families of mismatched coded excitations based on frequency modulation chirp and combined frequency modulation and Golay code. Here "mismatched" indicates that the coded excitations generate very small cross-correlations among themselves while each has a very strong autocorrelation...
February 12, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28231482/fourier-transform-infrared-and-raman-spectroscopy-in-the-study-of-phase-transitions-in-dipyrazolium-iodide-triiodide-experimental-and-theoretical-analysis
#11
M Węcławik, J Baran, P Durlak, Ł Marciniak, A Piecha-Bisiorek, R Jakubas
The paper presents the Infrared and Raman spectra of the powdered [C3N2H5(+)]2[I(-)∙I3(-)] crystal at the temperature intervals of 11-270K, covering two low-temperature phase transitions: discontinuous at 182/188K (cooling/heating) and continuous at 254K. The research shows that the vibrational states of the pyrazolium cations change significantly during discontinuous phase transition (III→II), while the continuous nature of successive structural transformation is more subtle and displays an insignificant change in the temperature coefficient of numerous vibrations during the II→I PT at 254K...
February 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28231477/effects-of-tdcs-on-motor-learning-and-memory-formation-a-consensus-and-critical-position-paper
#12
REVIEW
Ethan R Buch, Emiliano Santarnecchi, Andrea Antal, Jan Born, Pablo A Celnik, Joseph Classen, Christian Gerloff, Mark Hallett, Friedhelm C Hummel, Michael A Nitsche, Alvaro Pascual-Leone, Walter J Paulus, Janine Reis, Edwin M Robertson, John C Rothwell, Marco Sandrini, Heidi M Schambra, Eric M Wassermann, Ulf Ziemann, Leonardo G Cohen
Motor skills are required for activities of daily living. Transcranial direct current stimulation (tDCS) applied in association with motor skill learning has been investigated as a tool for enhancing training effects in health and disease. Here, we review the published literature investigating whether tDCS can facilitate the acquisition, retention or adaptation of motor skills. Work in multiple laboratories is underway to develop a mechanistic understanding of tDCS effects on different forms of learning and to optimize stimulation protocols...
January 29, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28231466/leaky-gate-model-intensity-dependent-coding-of-pain-and-itch-in-the-spinal-cord
#13
Shuohao Sun, Qian Xu, Changxiong Guo, Yun Guan, Qin Liu, Xinzhong Dong
Coding of itch versus pain has been heatedly debated for decades. However, the current coding theories (labeled line, intensity, and selectivity theory) cannot accommodate all experimental observations. Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory neurons. When activated, these Grp(+) neurons generated rarely seen, simultaneous robust pain and itch responses that were intensity dependent...
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28231454/zinc-complexes-of-diflunisal-synthesis-characterization-structure-antioxidant-activity-and-in-vitro-and-in-silico-study-of-the-interaction-with-dna-and-albumins
#14
Alketa Tarushi, Chrisoula Kakoulidou, Catherine P Raptopoulou, Vassilis Psycharis, Dimitris P Kessissoglou, Ioanna Zoi, Athanasios N Papadopoulos, George Psomas
From the reaction of ZnCl2 with the non-steroidal anti-inflammatory drug diflunisal (Hdifl), complex [Zn(difl-O)2(MeOH)4], 1 was formed, while in the presence of a N,N'-donor heterocyclic ligand 2,2'-bipyridylamine (bipyam), 2,2'-bipyridine (bipy), 1,10-phenanthroline (phen) and 2,2'-dipyridylketone oxime (Hpko), the complexes [Zn(difl-O,O')2(bipyam)], 2, [Zn(difl-O,O')2(bipy)], 3, [Zn(difl-O,O')2(phen)], 4 and [Zn(difl-O)2(Hpko)2], 5 were isolated, respectively. The complexes were characterized by physicochemical and spectroscopic techniques and the crystal structures of complexes 2, 3 and 5 were determined by X-ray crystallography...
February 12, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28231436/myocardial-homing-of-mesenchymal-stem-cells-following-intrapericardial-application-and-amplification-by-inflammation-an-experimental-pilot-study
#15
Nina Jung, Heinz Rupp, Rembert Koczulla, Claus Vogelmeier, Peter Alter
Recent studies demonstrated potential effects of stem cells on cardiac function in heart failure. However, influences of the technique of application remained undetermined. In the present study, the pericardial sac was used as depot for fluorescent-labeled mesenchymal stem cells in rats. To evaluate influences of inflammation on cell homing, a sterile pericarditis was induced by talc. It is shown that intrapericardial stem cells application is sufficient to provide myocardial penetration. The extent of homing was amplified by inflammation in a talc-induced pericarditis...
February 23, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28231419/absolute-photoionization-cross-sections-of-two-cyclic-ketones-cyclopentanone-cyclohexanone
#16
Chelsea Price, Yasmin Fathi, Giovanni Meloni
Absolute photoionization cross sections for cyclopentanone and cyclohexanone, as well as partial ionization cross sections for the dissociative ionized fragments, are presented in this investigation. Experiments are performed via a multiplexed photoionization mass spectrometer utilizing VUV synchrotron radiation supplied by the Advanced Light Source of Lawrence Berkeley National Laboratory. These results allow the quantification of these species that is relevant to investigate the kinetics and combustion reactions of potential biofuels...
February 23, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28231333/molecular-mechanisms-of-cooperative-binding-of-transcription-factors-runx1-cbf%C3%AE-ets1-on-the-tcr%C3%AE-gene-enhancer
#17
Kota Kasahara, Masaaki Shiina, Ikuo Fukuda, Kazuhiro Ogata, Haruki Nakamura
Ets1 is an essential transcription factor (TF) for several important physiological processes, including cell proliferation and differentiation. Its recognition of the enhancer region of the TCRα gene is enhanced by the cooperative binding of the Runx1-CBFβ heterodimer, with the cancelation of phosphorylation-dependent autoinhibition. The detailed mechanism of this interesting cooperativity between Ets1 and the Runx1-CBFβ heterodimer is still largely unclear. Here, we investigated the molecular mechanisms of this cooperativity, by using molecular dynamics simulations...
2017: PloS One
https://www.readbyqxmd.com/read/28231307/differential-regulation-of-c5a-receptor-1-in-innate-immune-cells-during-the-allergic-asthma-effector-phase
#18
Fanny Ender, Anna V Wiese, Inken Schmudde, Jing Sun, Tillman Vollbrandt, Peter König, Yves Laumonnier, Jörg Köhl
C5a drives airway constriction and inflammation during the effector phase of allergic asthma, mainly through the activation of C5a receptor 1 (C5aR1). Yet, C5aR1 expression on myeloid and lymphoid cells during the allergic effector phase is ill-defined. Recently, we generated and characterized a floxed green fluorescent protein (GFP)-C5aR1 knock-in mouse. Here, we used this reporter strain to monitor C5aR1 expression in airway, pulmonary and lymph node cells during the effector phase of OVA-driven allergic asthma...
2017: PloS One
https://www.readbyqxmd.com/read/28231304/a-four-day-western-style-dietary-intervention-causes-reductions-in-hippocampal-dependent-learning-and-memory-and-interoceptive-sensitivity
#19
Tuki Attuquayefio, Richard J Stevenson, Megan J Oaten, Heather M Francis
In animals, a Western style diet-high in saturated fat and added sugar-causes impairments in hippocampal-dependent learning and memory (HDLM) and perception of internal bodily state (interoception). In humans, while there is correlational support for a link between Western-style diet, HDLM, and interoception, there is as yet no causal data. Here, healthy individuals were randomly assigned to consume either a breakfast high in saturated fat and added sugar (Experimental condition) or a healthier breakfast (Control condition), over four consecutive days...
2017: PloS One
https://www.readbyqxmd.com/read/28231280/alkbh7-variant-related-to-prostate-cancer-exhibits-altered-substrate-binding
#20
Alice R Walker, Pavel Silvestrov, Tina A Müller, Robert H Podolsky, Gregory Dyson, Robert P Hausinger, Gerardo Andrés Cisneros
The search for prostate cancer biomarkers has received increased attention and several DNA repair related enzymes have been linked to this dysfunction. Here we report a targeted search for single nucleotide polymorphisms (SNPs) and functional impact characterization of human ALKBH family dioxygenases related to prostate cancer. Our results uncovered a SNP of ALKBH7, rs7540, which is associated with prostate cancer disease in a statistically significantly manner in two separate cohorts, and maintained in African American men...
February 2017: PLoS Computational Biology
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