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Alcohol addiction

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https://www.readbyqxmd.com/read/29469633/outpatient-addiction-treatment-for-problematic-alcohol-use-what-makes-patients-who-dropped-out-different-from-those-who-did-not
#1
Vincent Wagner, Didier Acier, Jean-Eric Dietlin
BACKGROUND: A minority of individuals with problematic alcohol use effectively seek help. Moreover, dropouts from care are not uncommon. It remains a major concern for health professionals, as adherence to treatment is significantly associated with better physical and psychological outcomes. OBJECTIVES: The main aim of this research was to assess what factors could distinguish patients with problematic alcohol use who dropped out from those who did not. METHODS: The sample included 150 patients followed-up in an outpatient treatment center in France for a problematic alcohol use...
February 22, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29463910/several-behavioral-traits-relevant-for-alcoholism-are-controlled-by-%C3%A9-2-subunit-containing-gaba-a-receptors-on-dopamine-neurons-in-mice
#2
Andrea Stojakovic, Magdalena Walczak, Przemysław E Cieślak, Aleksandra Trenk, Johan Sköld, Joanna Zajdel, Elahe Mirrasekhian, Camilla Karlsson, Annika Thorsell, Markus Heilig, Jan Rodriguez Parkitna, Tomasz Błasiak, David Engblom
The risk factors for developing alcohol addiction include impulsivity, high sensitivity to the rewarding action of ethanol, and low sensitivity to its sedative and intoxicating effects. Genetic variation in GABAA receptor subunits, including the ɣ2 subunit (Gabrg2), affects the risk for developing alcoholism. Alcohol directly potentiates GABAA receptors and activates the mesolimbic dopamine system. Here, we deleted Gabrg2 selectively in dopamine cells of adult mice. The deletion resulted in elevated firing of dopamine neurons and made them less sensitive to drugs acting at GABAA receptors...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29461932/clinical-outcomes-from-a-10-week-follow-up-psychoeducational-programme-for-dual-diagnosis
#3
J Chilton, D Crone, P J Tyson
BACKGROUND: Dual diagnosis covers a broad spectrum of mental health and substance misuse conditions occurring concurrently (NICE, 2016). Its manifestation is complex and as such, the disorder is recognized as influencing adherence to prescribed medication, service engagement and has a worse prognosis than substance use and mental health conditions occurring independently. AIMS: To determine the effectiveness of psycho-educational group therapy on a sample of dual diagnosis patients...
February 20, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29460163/noradrenergic-targets-for-the-treatment-of-alcohol-use-disorder
#4
REVIEW
Carolina L Haass-Koffler, Robert M Swift, Lorenzo Leggio
The role of norepinephrine (NE) in the development of alcohol use disorder (AUD) has been studied over the past several decades. However, the NE system has been largely ignored for many years as a potential target for medication development for AUD. More recently, preclinical and clinical studies have demonstrated the potential value of targeting NE signaling for developing new pharmacological treatments for AUD. This review contributes to a special issue of Psychopharmacology focused on promising targets for alcohol addiction...
February 20, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29459581/predictors-of-alcohol-relapse-following-liver-transplantation-for-alcohol-induced-liver-failure-consideration-of-a-d-selection-criteria
#5
Annie Gong, Gerald Y Minuk
Demonstrated abstinence from alcohol for over six months and successful completion of a formal alcohol addictions program are two commonly employed criteria for determining whether an alcoholic patient with liver failure should proceed to liver transplantation. In this systematic review of the medical literature, we review the justification for these criteria and consider other variables that have also been reported to be of predictive value. While abstinence from alcohol for over six months is supported by the medical literature, data are more limited regarding the value of formal alcohol addictions program as selection criteria for proceeding towards liver transplantation...
February 20, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29459211/a-new-approach-to-formulating-and-appraising-drug-policy-a-multi-criterion-decision-analysis-applied-to-alcohol-and-cannabis-regulation
#6
Ole Rogeberg, Daniel Bergsvik, Lawrence D Phillips, Jan van Amsterdam, Niamh Eastwood, Graeme Henderson, Micheal Lynskey, Fiona Measham, Rhys Ponton, Steve Rolles, Anne Katrin Schlag, Polly Taylor, David Nutt
BACKGROUND: Drug policy, whether for legal or illegal substances, is a controversial field that encompasses many complex issues. Policies can have effects on a myriad of outcomes and stakeholders differ in the outcomes they consider and value, while relevant knowledge on policy effects is dispersed across multiple research disciplines making integrated judgements difficult. METHODS: Experts on drug harms, addiction, criminology and drug policy were invited to a decision conference to develop a multi-criterion decision analysis (MCDA) model for appraising alternative regulatory regimes...
February 16, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29457674/a-review-of-brain-stimulation-methods-to-treat-substance-use-disorders
#7
REVIEW
Alexandria S Coles, Karolina Kozak, Tony P George
BACKGROUND: Substance use disorders (SUDs) are a leading cause of disability worldwide. While several pharmacological and behavioral treatments for SUDs are available, these may not be effective for all patients. Recent studies using non-invasive neuromodulation techniques including Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (tDCS), and Deep Brain Stimulation (DBS) have shown promise for SUD treatment. OBJECTIVE: Multiple studies were evaluated investigating the therapeutic potential of non-invasive brain stimulation techniques in treatment of SUDs...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29450896/circadian-mechanisms-in-alcohol-use-disorder-and-tissue-injury
#8
Booker T Davis, Robin M Voigt, Maliha Shaikh, Christopher B Forsyth, Ali Keshavarzian
Heavy use of alcohol can lead to addictive behaviors and to eventual alcohol related tissue damage. While increased consumption of alcohol has been attributed to various factors including level of alcohol exposure and environmental factors such as stress, data from behavioral scientists and physiological researchers is revealing roles for the circadian rhythm in mediating the development of behaviors associated with alcohol use disorder as well as the tissue damage that drives physiological disease. In this work, we compile recent work on the complex mutually influential relationship that exists between the core circadian rhythm and the pharmacodynamics of alcohol...
February 16, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29450253/drug-nicotine-and-alcohol-use-among-exercisers-does-substance-addiction-co-occur-with-exercise-addiction
#9
Attila Szabo, Mark D Griffiths, Rikke Aarhus Høglid, Zsolt Demetrovics
Background: Scholastic works suggest that those at risk for exercise addiction are also often addicted to illicit drugs, nicotine, and/or alcohol, but empirical evidence is lacking. Aims: The aim of the present work was to examine the co-occurrence of illicit drug, nicotine, and alcohol use frequency (prevalence of users) and severity (level of problem in users) among exercisers classified at three levels of risk for exercise addiction: (i) asymptomatic, (ii) symptomatic, and (iii) at-risk...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450252/alcohol-and-tobacco-use-among-methadone-maintenance-patients-in-vietnamese-rural-mountainside-areas
#10
Bach Xuan Tran, Huong Lan Thi Nguyen, Quynh Ngoc Hoang Le, Hue Thi Mai, Chau Ngo, Canh Dinh Hoang, Hai Hong Nguyen, Hai Quan Le, Hung Van Nguyen, Huong Thi Le, Tho Dinh Tran, Nabil Zary, Carl A Latkin, Thuc Minh Thi Vu, Roger C M Ho, Melvyn W B Zhang
Introduction: The expansion of methadone maintenance treatment (MMT) program requires more data about the factors affecting the effectiveness of treatment, especially behavioral data such as smoking and alcohol use among patients. This study aimed to examine the prevalence of tobacco and alcohol consumption and identify related factors among MMT patients in the Vietnamese rural mountainside. Methods: We interviewed 241 MMT patients in two clinics in Tuyen Quang, a mountainous province in Vietnam...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450239/alcohol-related-mental-imagery-the-effects-of-a-priming-dose-in-at-risk-drinkers
#11
Michael Yates, Sunjeev K Kamboj
Objectives: Drug related mental imagery is proposed to play a central role in addictive behaviour. However, little is known about such cognition or how it is pharmacologically modulated. Here, we test theoretical predictions of the 'elaborated intrusion' theory by comparing neutral with alcohol related mental imagery, and examine the effects of low dose alcohol on phenomenological aspects of this imagery. Methods: Alcohol related and neutral imagery was assessed after at risk drinkers (n = 40) consumed alcohol (0...
December 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450231/free-will-in-addictive-behaviors-a-matter-of-definition
#12
REVIEW
W Miles Cox, Eric Klinger, Javad Salehi Fadardi
Certain people are at risk for using alcohol or other drugs excessively and for developing problems with their use. Their susceptibility might arise from a variety of factors, including their genetic make-up, brain chemistry, family background, personality and other psychological variables, and environmental and sociocultural variables. Moreover, after substance use has become established, there are additional cognitive-motivational variables (e.g., substance-related attentional bias) that contribute to enacting behaviors consistent with the person's motivation to acquire and use the substance...
June 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450230/do-addicts-have-free-will-an-empirical-approach-to-a-vexing-question
#13
Gene M Heyman
Introduction: This paper addresses two overlapping questions: Do addicts have the capacity to voluntarily quit drugs? And do individuals knowingly pursue courses of action that they realize are bad for them, such as excessive drug use? Methods: I propose two testable versions of free will. First, the observation that activities differ in the degree to which they are susceptible to the influence of their consequences (e.g., costs and benefits) has proven a useful criterion for classifying behavior as voluntary or involuntary...
June 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450228/ordinary-people-associate-addiction-with-loss-of-free-will
#14
Andrew J Vonasch, Cory J Clark, Stephan Lau, Kathleen D Vohs, Roy F Baumeister
Introduction: It is widely believed that addiction entails a loss of free will, even though this point is controversial among scholars. There is arguably a downside to this belief, in that addicts who believe they lack the free will to quit an addiction might therefore fail to quit an addiction. Methods: A correlational study tested the relationship between belief in free will and addiction. Follow-up studies tested steps of a potential mechanism: 1) people think drugs undermine free will 2) people believe addiction undermines free will more when doing so serves the self 3) disbelief in free will leads people to perceive various temptations as more addictive...
June 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29447931/impulsive-mechanisms-influencing-relapse-in-alcohol-drinking
#15
Hugo E Reyes-Huerta, Cristiano Dos Santos, Kalina Martínez
Impulsivity has been related to different features of addictive behaviors. Growing data, generated in separated lines of research, suggest that different processes underlying impulsivity are associated to relapse in alcohol drinking. Considering the evidence, relapse can be understood as an impulsive choice or as an impulsive action. In the first case, the return to drinking behavior is a consequence of insensitive to delayed consequence, that is, to the discounting of delayed rewards. In the second case, relapse is a consequence of failures to inhibit prepotent responses...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29445521/a-method-for-co-creation-of-an-evidence-based-patient-workbook-to-address-alcohol-use-when-quitting-smoking-in-primary-care-a-case-study
#16
Nadia Minian, Aliya Noormohamed, Laurie Zawertailo, Dolly Baliunas, Norman Giesbrecht, Bernard Le Foll, Jürgen Rehm, Andriy Samokhvalov, Peter L Selby
Plain English summary: The purpose of this paper is to describe a patient engagement event designed to create an educational workbook with smokers who drink alcohol at harmful levels. The goal was to create a workbook that combined scientific evidence with patients' values, preferences, and needs. Fourteen adult smokers who drink alcohol were invited to the Centre for Addiction and Mental Health (CAMH) to take part in a four-hour event to help design the workbook with the CAMH research team...
2018: Research involvement and engagement
https://www.readbyqxmd.com/read/29439945/work-addiction-test-questionnaire-to-assess-workaholism-validation-of-french-version
#17
Hortense Ravoux, Bruno Pereira, Georges Brousse, Samuel Dewavrin, Thomas Cornet, Martial Mermillod, Laurie Mondillon, Guillaume Vallet, Farès Moustafa, Frédéric Dutheil
BACKGROUND: Work addiction is a significant public health problem with a growing prevalence. The Work Addiction Risk Test (WART) is the gold standard questionnaire to detect workaholism. OBJECTIVE: The main objective of this study was to validate the French version of the WART. METHODS: Questionnaires were proposed to voluntary French workers using the WittyFit software. There were no exclusion criteria. The questionnaire was administered anonymously for initial validity testing and readministered one week later for test-retest reliability...
February 13, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29439075/adult-psychosocial-outcomes-of-men-and-women-who-were-looked-after-or-adopted-as-children-prospective-observational-study
#18
Alison Teyhan, Dinithi Wijedasa, John Macleod
OBJECTIVE: To investigate whether men and women who were looked-after (in public care) or adopted as children are at increased risk of adverse psychological and social outcomes in adulthood. DESIGN, SETTING: Prospective observational study using the Avon Longitudinal Study of Parents and Children, which recruited pregnant women and their male partners in and around Bristol, UK in the early 1990s. PARTICIPANTS: 8775 women and 3654 men who completed questionnaires at recruitment (mean age: women 29; men 32) and 5 years later...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29437013/topiramate-induced-limbs-paraesthesia-and-rigid-fingers-flexion
#19
Andrea Domenico Pratico, Martino Ruggieri, Raffaele Falsaperla, Piero Pavone
Topiramate is a well-known anticonvulsant drug with a broad spectrum of actions. It has been proposed in the treatment of several types of epileptic seizures both in monotherapy and in add-on. Its usage has been extended to other disorders including migraine, essential tremor, obesity, alcohol and drug addiction. The most frequent side-effects of topiramate include dizziness, somnolence, insomnia, and ataxia. Paraesthesia, metabolic acidosis, kidney stones, hypohidrosis, cognitive impairment and eye symptoms have been also reported...
February 12, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29437012/marinobufagenin-in-urine-a-potential-marker-of-predisposition-to-ethanol-and-a-target-for-spironolactone
#20
Vladimir A Kashkin, Elena V Shekunova, Alexei Y Egorov, Alexei Bagrov
BACKGROUND AND OBJECTIVE: Previously it was demonstrated that digitalis-like cardiotonic steroid, marinobufagenin (MBG), is implicated in the development of ethanol addiction in rats. We hypothesized that (i) levels of sodium pump ligand, MBG, would be negatively correlated with amount of ethanol consumed by rats, and (ii) that spironolactone would oppose the MBG induced ethanol-seeking behavior and blood pressure in rats. METHODS: Voluntary consumption of 9% alcohol (vs...
February 11, 2018: Current Hypertension Reviews
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