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Aprotinin

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https://www.readbyqxmd.com/read/29782000/induction-of-nephrotic-syndrome-in-mice-by-retrobulbar-injection-of-doxorubicin-and-prevention-of-volume-retention-by-sustained-release-aprotinin
#1
Bernhard N Bohnert, Ferruh Artunc
Nephrotic syndrome is the most extreme manifestation of proteinuric kidney disease and characterized by heavy proteinuria, hypoalbuminemia, and edema due to sodium retention and hyperlipidemia. To study the pathophysiology of this syndrome, rodent models have been developed based on the injection of toxic substances such as doxorubicin causing podocyte damage. In mice, only few strains are susceptible to this model. In wildtype 129S1/SvImJ mice, the administration of doxorubicin by rapid intravenous injection to the retrobulbar sinus induces experimental nephrotic syndrome that features all the symptoms of human disease including sodium retention and edema...
May 6, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29692229/corticosteroids-and-other-anti-inflammatory-strategies-in-pediatric-heart-surgery-a-national-survey-of-practice
#2
Daniel P Fudulu, Alvin Schadenberg, Ben Gibbison, Ian Jenkins, Stafford Lightman, Gianni D Angelini, Serban Stoica
BACKGROUND: The role of steroids to mitigate the deleterious effects of pediatric cardiopulmonary bypass (CPB) remains a matter of debate; therefore, we aimed to assess preferences in administering corticosteroids (CSs) and the use of other anti-inflammatory strategies in pediatric cardiac surgery. METHODS: A 19-question survey was distributed to consultants in pediatric cardiac anesthesia from 12 centers across the United Kingdom and Ireland. RESULTS: Of the 37 respondents (37/60, 62%), 24 (65%) use CSs, while 13 (35%) do not use steroids at all...
May 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29679322/three-dimensional-hydrogel-based-culture-to-study-the-effects-of-toxicants-on-ovarian-follicles
#3
Hong Zhou, Ariella Shikanov
Various toxicants, such as drugs and their metabolites, can cause potential ovarian toxicity. As the functional units of the ovary, ovarian follicles are susceptible to this type of damage at all developmental stages. Studying the effects of toxicants on ovarian follicles is an important task. Three-dimensional (3D) hydrogels, such as fibrin alginate interpenetrating networks (FA-IPNs), can support ovarian follicle culture in vitro for extended periods of time and serve as a suitable tool for studying ovotoxicity...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29658906/reply-to-aprotinin-and-coronary-artery-bypass-surgery
#4
Alexandre Ouattara, Julien Amour
No abstract text is available yet for this article.
January 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29658905/aprotinin-and-coronary-artery-bypass-surgery
#5
Levent Cerit
No abstract text is available yet for this article.
January 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29628664/7-5-nacl-resuscitation-leads-to-abnormal-clot-fibrinolysis-after-severe-hemorrhagic-shock-and-its-correction-with-7-5-nacl-adenosine-lidocaine-and-mg-2
#6
Hayley Louise Letson, Geoffrey Phillip Dobson
Background: Hyperfibrinolysis is a common complication of hemorrhagic shock. Our aim was to examine the effect of small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ (ALM) on fibrinolysis in the rat model of hemorrhagic shock. Methods: Rats were anesthetized and randomly assigned to one of four groups: (1) baseline, (2) shock, (3) 7.5% NaCl controls, and (4) 7.5% NaCl ALM. Animals were bled for 20 min (42% blood loss) and left in shock for 60 min before resuscitation with 0...
January 2018: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29628009/aprotinin-impacts-8-isoprostane-after-coronary-artery-bypass-grafting
#7
V Toikkanen, T Rinne, R Nieminen, E Moilanen, J Laurikka, H Porkkala, M Tarkka, A A Mennander
BACKGROUND AND AIMS: The lungs participate in the modulation of the circulating inflammatory factors induced by coronary artery bypass grafting. We investigated whether aprotinin-which has been suggested to interact with inflammation-influences lung passage of key inflammatory factors after coronary artery bypass grafting. MATERIAL AND METHODS: A total of 40 patients undergoing coronary artery bypass grafting were randomized into four groups according to aprotinin dose: (1) high dose, (2) early low dose, (3) late low dose, and (4) without aprotinin...
April 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29616523/short-term-outcome-of-cardiac-surgery-under-cardiopulmonary-bypass-in-patients-who-refuse-transfusion-a-controlled-study
#8
Antonio Reyes Garcia, Gema Vega González, Ricardo Andino Ruiz
BACKGROUND: Although bloodless cardiac surgery has been successfully performed for many years, studies with controls permitting transfusion are few and their results inconclusive. This study compares the outcome of cardiac surgery on Jehovah's Witnesses (JW) refusing transfusion, with that of controls permitting transfusion if required. METHODS: Data from 172 operations in 162 JW were compared with 172 matched controls. Risk factors, preoperative, operative, 48 hour postoperative variables, outcome data and transfusions were recorded...
April 3, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29589208/significance-of-11-c-pib-pet-ct-in-cardiac-amyloidosis-compared-with-99m-tc-aprotinin-scintigraphy-a-pilot-study
#9
Ryogo Minamimoto, Toru Awaya, Kentaro Iwama, Masatoshi Hotta, Kazuhiko Nakajima, Risen Hirai, Osamu Okazaki, Yukio Hiroi
BACKGROUND: This study was to investigate the significance of 11 C-Pittsburgh B (PIB) PET/CT in patients with suspected cardiac amyloidosis compared with 99m Tc-aprotinin scintigraphy. METHODS: Thirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this prospective pilot study. Participants were scheduled to undergo a series of 11 C-PIB PET/CT and 99m Tc-aprotinin within a 2-month period. Finally, we evaluated nine cases who underwent both imaging modalities, and compared imaging results with clinical and pathological results and prognosis...
March 27, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29575137/preparation-of-canine-c-reactive-protein-serum-reference-material-a-feasibility-study
#10
Francesca Canalias, Matilde Piñeiro, Raquel Pato, Raquel Peña, Lluís Bosch, Lourdes Soler, Natalia García, Fermín Lampreave, Yolanda Saco, Anna Bassols
BACKGROUND: The availability of a species-specific reference material is essential for the harmonization of results obtained in different laboratories by different methods. OBJECTIVES: We describe the preparation of a canine C-reactive protein (cCRP) serum reference material containing purified cCRP stabilized in a serum matrix. The material can be used by manufacturers to assign values to their calibrator and control materials. METHODS: The serum matrix was obtained using blood collected from healthy dogs, stabilized and submitted for a delipidation process...
March 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29502105/safety-of-perioperative-aprotinin-administration-during-isolated-coronary-artery-bypass-graft-surgery-insights-from-the-art-arterial-revascularization-trial
#11
Umberto Benedetto, Douglas G Altman, Stephen Gerry, Alastair Gray, Belinda Lees, Gianni D Angelini, Marcus Flather, David P Taggart
BACKGROUND: There is still uncertainty about the safety of aprotinin for coronary artery bypass graft surgery. The ART (Arterial Revascularization Trial) was designed to compare survival after bilateral versus single internal thoracic artery grafting. Many of the ART patients (≈30%) received perioperative aprotinin. We investigated the association between perioperative aprotinin administration and short-term (in-hospital) and long-term outcomes by performing a post hoc analysis of the ART...
March 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29471689/mediation-of-inflammatory-ascites-formation-induced-by-macromolecules-in-mice
#12
Károly Baintner
The first 60-min phase of inflammatory ascites formation was studied by intraperitoneally (i.p.) administered macromolecular inducers: yeast cell wall zymosan binds to specific macrophage receptors, polyethyleneimine (PEI) and concanavalin A (ConA), produces non-covalent cross-links on the surface of various cells, while λ-carrageenan may function as a contact activator. Depletion of peritoneal macrophages was performed by overnight pretreatment with diphtheria toxin in transgenic mice, resulting in a significant (p < 0...
February 23, 2018: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29462500/antifibrinolytic-drugs-for-treating-primary-postpartum-haemorrhage
#13
REVIEW
Haleema Shakur, Danielle Beaumont, Sue Pavord, Angele Gayet-Ageron, Katharine Ker, Hatem A Mousa
BACKGROUND: Postpartum haemorrhage (PPH) - heaving bleeding within the first 24 hours after giving birth - is one of the main causes of death of women after childbirth. Antifibrinolytics, primarily tranexamic acid (TXA), have been shown to reduce bleeding in surgery and safely reduces mortality in trauma patients with bleeding without increasing the risk of adverse events.An earlier Cochrane review on treatments for primary PPH covered all the various available treatments - that review has now been split by types of treatment...
February 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29433579/the-role-of-fibrinolysis-inhibition-in-engineered-vascular-networks-derived-from-endothelial-cells-and-adipose-derived-stem-cells
#14
Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl, Wolfgang Holnthoner
BACKGROUND: Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering. Still, to translate this model into clinics several in vitro parameters including growth medium and scaffold degradation need to be fine-tuned. METHODS: We recently described the co-culture of adipose-derived stem cells with endothelial cells in fibrin, resulting in capillary formation in vitro as well as their perfusion in vivo...
February 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29363322/albuminuria-in-kidney-transplant-recipients-is-associated-with-increased-urinary-serine-proteases-and-activation-of-the-epithelial-sodium-channel
#15
Gitte Rye Hinrichs, Jannie Solmunde Michelsen, Rikke Zachar, Ulla Glenert Friis, Per Svenningsen, Henrik Birn, Claus Bistrup, Boye L Jensen
Albuminuria predicts adverse renal outcome in kidney transplant recipients. The present study addressed the hypothesis that albuminuria is associated with increased urine serine proteases with the ability to activate the epithelial sodium channel (ENaC) and with greater extracellular volume and higher blood pressure. In a cross-sectional design, kidney transplant recipients with (n=18) and without (n=19) albuminuria were included for office blood pressure measurements, estimation of volume status by bioimpedance, and collection of spot urine and plasma samples...
January 24, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29334656/activated-protein-c-suppresses-osteoclast-differentiation-via-endothelial-protein-c-receptor-protease-activated-receptor-1-sphingosine-1-phosphate-receptor-and-apolipoprotein-e-receptor-2
#16
Kakunoshin Yoshida, Nobuyuki Akita, Takayuki Okamoto, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo, Motomu Shimaoka, Koji Suzuki, Tatsuya Hayashi
INTRODUCTION: Bone remodeling relies on a delicate balance between formation and resorption of bone tissues, processes in which bone-forming osteoblasts and bone-resorbing osteoclasts play central roles. Recently, we reported that anticoagulant activated protein C (APC) promotes osteoblast proliferation, but the role of the blood coagulation system in bone remodeling remains unclear. In this study, to further elucidate the relationship between bone remodeling and blood coagulation, we investigated the effect of APC on osteoclast differentiation...
March 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29317266/biochemical-characterization-of-unusual-cysteine-protease-of-p-falciparum-metacaspase-2-mca-2
#17
Vandana, Agam P Singh, Jitendra Singh, Ruby Sharma, Mymoona Akhter, Pradyumna K Mishra, Ajay K Saxena, Rajnikant Dixit, Brijesh Rathi, Anju Katyal, Kailash C Pandey
Earlier studies on Plasmodium apoptosis revealed the presence of proteases with caspases like- activity, which are known as "metacaspases". Although this family of cysteine proteases is structurally similar to caspases with Cys-His dyad but their evolutionary significance and functional relevance remains largely unknown. These proteases are considered to be an important target against malaria due to their absence in humans. In this report, we have biochemically characterized metacaspase-2 (PfMCA-2) of P...
March 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29302118/blood-and-blood-product-conservation-results-of-strategies-to-improve-clinical-outcomes-in-open-heart-surgery-patients-at-a-tertiary-hospital
#18
Junaid H Khan, Emily A Green, Jimmin Chang, Alexandria M Ayala, Marilyn S Barkin, Emily E Reinys, Jeffrey Stanton, Russell D Stanten
Blood product usage is a quality outcome for patients undergoing cardiac surgery. To address an increase in blood product usage since the discontinuation of aprotinin, blood conservation strategies were initiated at a tertiary hospital in Oakland, CA. Improving transfusion rates for open heart surgery patients requiring Cardiopulmonary bypass (CPB) involved multiple departments in coordination. Specific changes to conserve blood product usage included advanced CPB technology upgrades, and precise individualized heparin dose response titration assay for heparin and protamine management...
December 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29299920/targeted-imaging-of-brain-tumors-with-a-framework-nucleic-acid-probe
#19
Tian Tian, Jiang Li, Cao Xie, Yanhong Sun, Haozhi Lei, Xinyi Liu, Jiaoyun Xia, Jiye Shi, Lihua Wang, Weiyue Lu, Chunhai Fan
Development of agents for delivering drugs and imaging probes across the blood-brain barrier (BBB) remains a major challenge. In this study, we designed a biocompatible framework nucleic acid (FNA)-based imaging probe for brain tumor-targeting. We employed a typical type of FNAs, tetrahedral DNA nanostructures (TDNs), as the building block, which were modified with angiopep-2 (ANG), a 19-mer peptide derived from human Kunitz domain of aprotinin. This probe exhibited high binding efficiency with low-density lipoprotein receptor-related protein-1 (LRP-1) of BBB and glioma...
January 31, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29233750/fibrin-hydrogels-as-a-xenofree-and-rapidly-degradable-support-for-transplantation-of-retinal-pigment-epithelium-monolayers
#20
Jarel K Gandhi, Zahid Manzar, Lori A Bachman, Cynthia Andrews-Pfannkoch, Travis Knudsen, Matthew Hill, Hannah Schmidt, Raymond Iezzi, Jose S Pulido, Alan D Marmorstein
Recent phase 1 trials of embryonic stem cell and induced pluripotent stem cell (iPSCs) derived RPE transplants for the treatment of macular degeneration have demonstrated the relative safety of this process. However, there is concern over clumping, thickening, folding, and wrinkling of the transplanted RPE. To deliver a flat RPE monolayer, current phase 1 trials are testing synthetic substrates for RPE transplantation. These substrates, however, cause localized inflammation and fibrosis in animal models due to long degradation times...
February 2018: Acta Biomaterialia
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