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https://www.readbyqxmd.com/read/29342154/three-unrelated-and-unexpected-amino-acids-determine-the-susceptibility-of-the-interface-cysteine-to-a-sulfhydryl-reagent-in-the-triosephosphate-isomerases-of-two-trypanosomes
#1
Selma Díaz-Mazariegos, Nallely Cabrera, Ruy Perez-Montfort
Proteins with great sequence similarity usually have similar structure, function and other physicochemical properties. But in many cases, one or more of the physicochemical or functional characteristics differ, sometimes very considerably, among these homologous proteins. To better understand how critical amino acids determine quantitative properties of function in proteins, the responsible residues must be located and identified. This can be difficult to achieve, particularly in cases where multiple amino acids are involved...
2018: PloS One
https://www.readbyqxmd.com/read/29342096/high-resolution-lipidomics-of-the-early-life-stages-of-the-red-seaweed-porphyra-dioica
#2
Elisabete da Costa, Vitor Azevedo, Tânia Melo, Andreia M Rego, Dmitry V Evtuguin, Pedro Domingues, Ricardo Calado, Rui Pereira, Maria H Abreu, Maria R Domingues
Porphyra dioica is a commercial seaweed consumed all over the world, mostly in the shape of nori sheets used for "sushi" preparation. It is a well-known part of the Asian diet with health benefits, which have been associated, among others, to the high levels of n-3 and n-6 fatty acids in this red alga. However, other highly valued lipids of Porphyra are polar lipids that remain largely undescribed and can have both nutritional value and bioactivity, thus could contribute to the valorization of this seaweed...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29341963/role-of-the-anesthesiologist-intensivist-outside-the-icu-opportunity-to-add-value-for-the-hospital-or-an-unnecessary-distraction
#3
Suzanne Bennett, Erin Grawe, Courtney Jones, Sean A Josephs, Maggie Mechlin, William E Hurford
PURPOSE OF REVIEW: Given the extremely expensive nature of critical care medicine, it seems logical that intensivists should play an active role in designing efficient systems of care. The true value of intensivists, however, is not well defined. RECENT FINDINGS: Anesthesiologists have taken key roles in improving patient safety in the operating room. Anesthesia-related mortality rates have decreased from 20 deaths per 100 000 anesthetics in the early 1980s to less than one death per 100 000 currently...
January 15, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29341892/premature-aging-in-behavior-and-immune-functions-in-tyrosine-hydroxylase-haploinsufficient-female-mice-a-longitudinal-study
#4
A Garrido, J Cruces, N Ceprián, C Hernández-Sánchez, M De la Fuente
Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. In this context, there is an age-related alteration of the physiological response to acute stress, which is modulated by catecholamine (CA), final products of the sympathetic-adreno-medullary axis. The involvement of CA in essential functions of the nervous system is consistent with the neuropsychological deficits found in mice with haploinsufficiency (hemizygous; HZ) of tyrosine hydroxylase (TH) enzyme (TH-HZ)...
January 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29341818/medicine-as-it-should-be-teaching-team-and-teamwork-during-a-palliative-care-clerkship
#5
Barbara A Head, Christian Davis Furman, Andrew M Lally, Kimberly Leake, Mark Pfeifer
BACKGROUND: Interprofessional Education (IPE) is an important component of medical education. Rotations with palliative care interdisciplinary teams (IDTs) provide an optimal environment for IPE and teaching teamwork skills. OBJECTIVE: Our objective was to assess the learning of senior medical students during a palliative care rotation. DESIGN: A constant comparison method based on grounded theory was used in this qualitative study. SETTING/SUBJECTS: Senior medical students completed a semi-structured reflective writing exercise after a required one-week palliative care clerkship...
January 17, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29341552/developing-the-organisational-culture-in-a-healthcare-setting
#6
Adele Nightingale
This article aims to define organisational culture and explain why it is important to patients, carers and those working in healthcare environments. Organisational culture is not a new concept and the literature on the subject is well-established. However, because of the changing dynamics of the NHS, there has been a shift away from 'what' the NHS stands for, often relating to its history and rituals, to 'who' it functions for, including how healthcare professionals such as nurses can develop and drive the organisational culture...
January 17, 2018: Nursing Standard
https://www.readbyqxmd.com/read/29341491/clinical-outcomes-of-carbon-ion-radiotherapy-with-concurrent-chemotherapy-for-locally-advanced-uterine-cervical-adenocarcinoma-in-a-phase-1-2-clinical-trial-protocol-1001
#7
Noriyuki Okonogi, Masaru Wakatsuki, Shingo Kato, Kumiko Karasawa, Hiroki Kiyohara, Shintaro Shiba, Daijiro Kobayashi, Takashi Nakano, Tadashi Kamada, Makio Shozu
We conducted a phase 1/2 study to evaluate the efficacy and safety of carbon ion radiotherapy (C-ion RT) with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma. Thirty-three patients were enrolled between April 2010 and March 2014. Treatment consisted of C-ion RT with concurrent weekly cisplatin at a dose of 40 mg/m2 . In the phase 1 component, the total dose was escalated from 68.0 Gy (relative biological effectiveness [RBE]) to 74.4 Gy (RBE) to determine the maximum tolerated dose of C-ion RT...
January 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29341455/microsatellite-markers-for-evaluating-the-diversity-of-the-natural-killer-complex-and-major-histocompatibility-complex-genomic-regions-in-domestic-horses
#8
C Horecky, E Horecka, J Futas, E Janova, P Horin, A Knoll
Genotyping microsatellite markers represents a standard, relatively easy and inexpensive method of assessing genetic diversity of complex genomic regions in various animal species, such as the major histocompatibility complex (MHC) and/or natural killer cell receptor (NKR) genes. MHC-linked microsatellite markers have been identified and some of them were used for characterizing MHC polymorphism in various species, including horses. However, most of those were MHC class II markers, while MHC class I and III sub-regions were less well covered...
January 17, 2018: HLA
https://www.readbyqxmd.com/read/29341318/cognitive-trajectories-and-spectrum-of-neuropathology-in-superagers-the-first-ten-cases
#9
Emily Rogalski, Tamar Gefen, Qinwen Mao, Maureen Connelly, Sandra Weintraub, Changiz Geula, Eileen H Bigio, M-Marsel Mesulam
On average, memory capacity is significantly higher in populations of 50-60 year olds than in populations of 80 year olds. We define SuperAgers as individuals 80 or older whose episodic memory capacity is at least as good as that of cognitively average individuals in their 50s and 60s. SuperAgers therefore have memory capacity that is superior for age. Previous work showed that SuperAgers have greater cortical volumes and greater resistance to age-related cortical atrophy than 'cognitively average' individuals of the same age...
January 17, 2018: Hippocampus
https://www.readbyqxmd.com/read/29341293/circularly-polarized-luminescence-appeared-from-complete-inorganic-materials-encapsulating-guest-lanthanide-oxides-in-host-chiral-silica
#10
Ren-Hua Jin
Recently, circularly polarized luminescence (CPL)-active systems have become a very hot and interesting subject in chirality- and optics-related areas. The CPL-active systems are usually available by two approaches: combining covalently a luminescent centre to chiral motif or associating the guest of luminescent probe to a chiral host. However, all the chiral components in CPL materials were organics although the parts of luminescent were alternative as organics or inorganics. Herein, we proposed the first totally inorganic CPL-active system by "luminescent guest - chiral host" strategy...
January 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29341191/working-and-caring-for-a-child-with-chronic-illness-a-review-of-current-literature
#11
A M Kish, P A Newcombe, D M Haslam
BACKGROUND: Advances in medical knowledge have contributed to the increase in the number of children living with some form of long-term chronic illness or condition. As a consequence of these advancements, treatments that are more accessible and easier to administer, usually within a child's home, have been developed. However, this may mean that parents take on greater treatment responsibility and require extra time and energy to meet these tasks, additional to other responsibilities...
January 16, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29341148/outcomes-after-prophylactic-gastrectomy-for-hereditary-diffuse-gastric-cancer
#12
R T van der Kaaij, J P van Kessel, J M van Dieren, P Snaebjornsson, O Balagué, F van Coevorden, L E van der Kolk, K Sikorska, A Cats, J W van Sandick
BACKGROUND: Patients with hereditary diffuse gastric cancer and a CDH1 mutation have a 60-80 per cent lifetime risk of developing diffuse gastric cancer. Total prophylactic gastrectomy eliminates this risk, but is associated with considerable morbidity. The effectiveness (removal of all gastric mucosa) and outcomes of this procedure were evaluated retrospectively. METHODS: All consecutive individuals undergoing a prophylactic gastrectomy for a CDH1 mutation or gastric signet ring cell foci at the authors' institute between 2005 and 2017 were included...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29341113/prospective-emotion-enables-episodic-prospection-to-shift-time-preference
#13
Shunmin Zhang, Juan Peng, LingLing Qin, Tao Suo, Tingyong Feng
The episodic effect suggests that episodic prospection (imagining future events) can effectively reduce time discounting, the propensity to discount the value of delayed rewards relative to immediate ones. However, less clear is how episodic prospection modulates time preference. As engagement in episodic prospection usually evokes prospective emotions, it was proposed that episodic prospection might work by inducing prospective emotions. Although one previous study has attempted to provide evidence to the emotional account of the episodic effect, shortcomings in its experimental design make its conclusion questionable...
January 16, 2018: British Journal of Psychology
https://www.readbyqxmd.com/read/29341020/mri-in-the-study-of-animal-models-of-stroke
#14
Pedro Ramos-Cabrer, Daniel Padro
Stroke consists of the loss of cerebral functions resulting from the interruption of blood supply to a region of the brain, and represents the second cause of death and the leading cause of major disability in adults in Europe. Stroke is a very active field of research at preclinical and clinical levels, and Magnetic Resonance Imaging (MRI) is one of the most powerful tools that scientist and clinicians have for the study of the onset, evolution and consequences of this devastating disease, as well as for the monitoring of the success of available treatments, or for the development of novel therapeutic strategies...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29340968/a-novel-blink-detection-method-based-on-pupillometry-noise
#15
Ronen Hershman, Avishai Henik, Noga Cohen
Pupillometry (or the measurement of pupil size) is commonly used as an index of cognitive load and arousal. Pupil size data are recorded using eyetracking devices that provide an output containing pupil size at various points in time. During blinks the eyetracking device loses track of the pupil, resulting in missing values in the output file. The missing-sample time window is preceded and followed by a sharp change in the recorded pupil size, due to the opening and closing of the eyelids. This eyelid signal can create artificial effects if it is not removed from the data...
January 16, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29340961/metabolic-syndrome-and-its-components-among-korean-submariners-a-retrospective-cross-sectional-study
#16
Jihun Kang, Yun-Mi Song
PURPOSE: Metabolic syndrome (MetS) is a cluster of inter-related risk factors for cardiovascular disease and diabetes. Although submariners tend to be exposed to unhealthy environmental factors, such as a confined work environment, physical inactivity, and circadian disruption, little is known regarding whether the risks of MetS and its components are associated with submarine service. The present study aimed to evaluate the risks of MetS and its components among submariners. METHODS: A total of 5090 subjects (513 submariners and 4577 non-submariners) were included in the present study...
January 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29340887/toward-evidence-based-chinese-medicine-status-quo-opportunities-and-challenges
#17
Yao-Long Chen, Chen Zhao, Li Zhang, Bo Li, Chuan-Hong Wu, Wei Mu, Jia-Ying Wang, Ke-Hu Yang, You-Ping Li, Chiehfeng Chen, Yong-Yan Wang, Chen Wang, Zhao-Xiang Bian, Hong-Cai Shang
How to test the treatments of Chinese medicine (CM) and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of CM. For centuries, various approaches have been used to identify and measure the efficacy and safety of CM. However, the high-quality evidence related to CM that produced in China is still rare. Over the recent years, evidence-based medicine (EBM) has been increasingly applied to CM, strengthening its theoretical basis...
January 16, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29340874/lattice-boltzmann-simulations-of-droplet-dynamics-in-time-dependent-flows
#18
F Milan, M Sbragaglia, L Biferale, F Toschi
We study the deformation and dynamics of droplets in time-dependent flows using 3D numerical simulations of two immiscible fluids based on the lattice Boltzmann model (LBM). Analytical models are available in the literature, which assume the droplet shape to be an ellipsoid at all times (P.L. Maffettone, M. Minale, J. Non-Newton. Fluid Mech 78, 227 (1998); M. Minale, Rheol. Acta 47, 667 (2008)). Beyond the practical importance of using a mesoscale simulation to assess "ab initio" the robustness and limitations of such theoretical models, our simulations are also key to discuss --in controlled situations-- some relevant phenomenology related to the interplay between the flow time scales and the droplet time scales regarding the "transparency" transition for high enough shear frequencies for an external oscillating flow...
January 16, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29340712/membrane-position-dependency-of-the-pka-and-conductivity-of-the-protein-ion-channel
#19
Nikolay A Simakov, Maria G Kurnikova
The dependency of current-voltage characteristics of the α-hemolysin channel on the channel position within the membrane was studied using Poisson-Nernst-Planck theory of ion conductivity with soft repulsion between mobile ions and protein atoms (SP-PNP). The presence of the membrane environment also influences the protonation state of the residues at the boundary of the water-lipid interface. In this work, we predict that Asp and Lys residues at the protein rim change their protonation state upon penetration to the lipid environment...
January 16, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29340654/antioxidant-angiotensin-converting-enzyme-inhibitory-activity-and-other-functional-properties-of-egg-white-proteins-and-their-derived-peptides-a-review
#20
E D N S Abeyrathne, X Huang, D U Ahn
Egg white contains many functionally important proteins: ovalbumin (54%), ovotransferrin (12%), ovomucoid (11%), ovoglobulin (G2 and G3, 8%), ovomucin (3.5%), and lysozyme (3.5%) are major proteins, while ovoinhibitors, ovomacroglobulin, ovoglycoprotein, ovoflavoprotein, thiamine-binding proteins, and avidin are minor proteins present in egg white. These proteins, as well as the peptides derived from the proteins, have been recognized for their functional importance as antioxidant, antimicrobial, metal-chelating, anti-viral, anti-tumour, and angiotensin-converting enzyme (ACE)-inhibitory activities...
January 11, 2018: Poultry Science
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