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https://www.readbyqxmd.com/read/27906527/behavioral-epigenetics
#1
David S Moore
Why do we grow up to have the traits we do? Most 20th century scientists answered this question by referring only to our genes and our environments. But recent discoveries in the emerging field of behavioral epigenetics have revealed factors at the interface between genes and environments that also play crucial roles in development. These factors affect how genes work; scientists now know that what matters as much as which genes you have (and what environments you encounter) is how your genes are affected by their contexts...
December 1, 2016: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/27906505/what-do-we-learn-about-development-from-baby-robots
#2
Pierre-Yves Oudeyer
Understanding infant development is one of the great scientific challenges of contemporary science. In addressing this challenge, robots have proven useful as they allow experimenters to model the developing brain and body and understand the processes by which new patterns emerge in sensorimotor, cognitive, and social domains. Robotics also complements traditional experimental methods in psychology and neuroscience, where only a few variables can be studied at the same time. Moreover, work with robots has enabled researchers to systematically explore the role of the body in shaping the development of skill...
December 1, 2016: Wiley Interdisciplinary Reviews. Cognitive Science
https://www.readbyqxmd.com/read/27906491/influence-of-alcohol-%C3%AE-fluorination-on-hydrogen-bond-acidity-of-conformationally-flexible-substrates
#3
Jerome Graton, Guillaume Compain, François Besseau, Elena Bogdan, Joe Watts, Lewis Mtashobya, Zhong Wang, Alex Weymouth-Wilson, Nicolas Galland, Jean-Yves Le Questel, Bruno Linclau
Rational modulations of molecular interactions are of significant importance in compound properties optimization. We have previously shown that fluorination of conformationally rigid cyclohexanols leads to attenuation of their hydrogen-bond (H-bond) donating capacity (pKAHY) when OH***F intramolecular hydrogen-bond (IMHB) interactions occur, as opposed to an increase in pKAHY due to the fluorine electronegativity. This work has now been extended to a wider range of aliphatic β-fluorohydrins with increasing degrees of conformational flexibility...
December 1, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27906479/knowledge-and-practice-in-cardiovascular-disease-prevention-among-hospital-registered-nurses-a-cross-sectional-study
#4
Shu Ding, Ying Deng, Sai Lu, Karen V Lamb, Ying Zhang, Ying Wu
AIMS AND OBJECTIVES: To investigate the knowledge and clinical practices of cardiovascular disease (CVD) prevention among registered nurses (RNs) who worked on three major clinical units in Beijing hospitals. BACKGROUND: Health education on CVD prevention is an important component of nursing practice, however, Chinese RNs' knowledge and practice patterns have been poorly explored in previous studies. DESIGN: A cross-sectional study. METHODS: A stratified random sample of three hundred RNs was recruited from two tertiary hospitals in Beijing, China...
December 1, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27906440/supramicrosurgical-lymphatico-venular-anastomosis-lva-in-treating-lymphoedema-36-months-preliminary-report
#5
P Gennaro, G Gabriele, M Mihara, K Kikuchi, C Salini, I Aboh, F Cascino, G Chisci, C Ungari
OBJECTIVE: Lymphoedema of the extremities is a widespread pathological condition that mostly occurs as a complication of cancer resections, especially in women. Conventional therapy refers to conservative and physiotherapeutic approaches. Surgical strategies have been widely reported in the literature and are still challenging. Part of this literature focuses on the supra microsurgical lymphaticovenular anastomosis (LVA) technique. LVA is characterized by a high success rate, minimal invasivity and broad indications...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27906284/electrically-reconfigurable-split-ring-resonator-covered-by-nematic-liquid-crystal-droplet
#6
Kepeng Qiu, Ning Jia, Zijun Liu, Chen Wu, Yuancheng Fan, Quanhong Fu, Fuli Zhang, Weihong Zhang
In this paper, an electrically reconfigurable split ring resonator (SRR) covered by sessile droplet of nematic liquid crystal (LC) is demonstrated experimentally. The magnetic resonance of single SRR decreases gradually by 237 MHz as external bias voltage is applied, resulting from increasing fringing capacitance due to liquid crystal molecular reorientation along local electric field distribution. The transmission phase can be modulated by more than 100 degrees. Furthermore, frequency tuning range of SRR increases with the droplet height, because of the significant enhancement for SRR capacitance difference between LC states with/without bias voltage...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906261/impact-of-nonstationary-optical-illumination-on-image-reconstruction-in-optoacoustic-tomography
#7
Yang Lou, Kun Wang, Alexander A Oraevsky, Mark A Anastasio
Optoacoustic tomography (OAT), also known as photoacoustic tomography, is a rapidly emerging hybrid imaging technique that possesses great potential for a wide range of biomedical imaging applications. In OAT, a laser is employed to illuminate the tissue of interest and acoustic signals are produced via the photoacoustic effect. From these data, an estimate of the distribution of the absorbed optical energy density within the tissue is reconstructed, referred to as the object function. This quantity is defined, in part, by the distribution of light fluence within the tissue that is established by the laser source...
December 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27906119/degrading-traumatic-memories-with-eye-movements-a-pilot-functional-mri-study-in-ptsd
#8
Kathleen Thomaes, Iris M Engelhard, Marit Sijbrandij, Danielle C Cath, Odile A Van den Heuvel
BACKGROUND: Eye movement desensitization and reprocessing (EMDR) is an effective treatment for posttraumatic stress disorder (PTSD). During EMDR, the patient recalls traumatic memories while making eye movements (EMs). Making EMs during recall is associated with decreased vividness and emotionality of traumatic memories, but the underlying mechanism has been unclear. Recent studies support a "working-memory" (WM) theory, which states that the two tasks (recall and EMs) compete for limited capacity of WM resources...
2016: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/27906073/gut-barrier-structure-mucosal-immunity-and-intestinal-microbiota-in-the-pathogenesis-and-treatment-of-hiv-infection
#9
REVIEW
Camilla Tincati, Daniel C Douek, Giulia Marchetti
Over the past 10 years, extensive work has been carried out in the field of microbial translocation in HIV infection, ranging from studies on its clinical significance to investigations on its pathogenic features. In the present work, we review the most recent findings on this phenomenon, focusing on the predictive role of microbial translocation in HIV-related morbidity and mortality, the mechanisms by which it arises and potential therapeutic approaches. From a clinical perspective, current work has shown that markers of microbial translocation may be useful in predicting clinical events in untreated HIV infection, while conflicting data exist on their role in cART-experienced subjects, possibly due to the inclusion of extremely varied patient populations in cohort studies...
April 11, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905982/the-use-of-a-lot-quality-assurance-sampling-methodology-to-assess-and-manage-primary-health-interventions-in-conflict-affected-west-darfur-sudan
#10
Kiemanh Pham, Emily Chambers Sharpe, William M Weiss, Alexander Vu
BACKGROUND: Organizations working in conflict-affected areas have a need to monitor and evaluate their programs, however this is often difficult due to the logistical challenges of conflict areas. Lot quality assurance sampling may be a suitable method of assessing programs in these situations. METHODS: We conducted a secondary data analysis of information collected during Medair's routine program management functions. Medair's service area in West Darfur, Sudan was divided into seven supervisory areas...
October 6, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905967/alzheimer-s-and-other-dementias-in-canada-2011-to-2031-a-microsimulation-population-health-modeling-pohem-study-of-projected-prevalence-health-burden-health-services-and-caregiving-use
#11
Douglas G Manuel, Rochelle Garner, Philippe Finès, Christina Bancej, William Flanagan, Karen Tu, Kim Reimer, Larry W Chambers, Julie Bernier
BACKGROUND: Worldwide, there is concern that increases in the prevalence of dementia will result in large demands for caregivers and supportive services that will be challenging to address. Previous dementia projections have either been simple extrapolations of prevalence or macrosimulations based on dementia incidence. METHODS: A population-based microsimulation model of Alzheimer's and related dementias (POHEM:Neurological) was created using Canadian demographic data, estimates of dementia incidence, health status (health-related quality of life and mortality risk), health care costs and informal caregiving use...
November 3, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905966/rapid-assessment-of-disability-in-the-philippines-understanding-prevalence-well-being-and-access-to-the-community-for-people-with-disabilities-to-inform-the-w-dare-project
#12
Manjula Marella, Alexandra Devine, Graeme Ferdinand Armecin, Jerome Zayas, Ma Jesusa Marco, Cathy Vaughan
BACKGROUND: International recognition that people with disabilities were excluded from the Millennium Development Goals has led to better inclusion of people with disabilities in the recently agreed Global Goals for Sustainable Development (SDGs) 2015-2030. Given the current global agenda for disability inclusion, it is crucial to increase the understanding of the situation of people with disabilities in the Philippines. The aim of this study was to estimate the prevalence of disability and compare the well-being and access to the community between people with and without disabilities...
August 2, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905938/the-impact-of-epidemics-on-labor-market-identifying-victims-of-the-middle-east-respiratory-syndrome-in-the-korean-labor-market
#13
Ayoung Lee, Joonmo Cho
BACKGROUND: The vulnerability approach suggests that disasters such as epidemics have different effects according not only to physical vulnerability but also to economic class (status). This paper examines the effect of the Middle East Respiratory Syndrome epidemic on the labor market to investigate whether vulnerable groups become more vulnerable due to an interaction between the socio-economic structure and physical risk. METHODS: This paper examines the effect of the Middle East Respiratory Syndrome epidemic on the labor market by considering unemployment status, job status, working hours, reason for unemployment and underemployment status...
December 1, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27905936/multiple-bias-analysis-as-a-technique-to-address-systematic-error-in-measures-of-abortion-related-mortality
#14
Caitlin Gerdts, Jennifer Ahern
BACKGROUND: The UN Millennium Development Goals (MDGs) and Sustainable Development Goals (SDGs) have brought heightened global attention to the measurement of maternal mortality. It is imperative that new and novel approaches be used to measure maternal mortality and to better understand existing data. In this paper we present one approach: an epidemiologic framework for identifying the identification and quantification of systematic error (multiple-bias analysis), outline the necessary steps for investigators interested in conducting multiple-bias analyses in their own data, and suggest approaches for reporting such analyses in the literature...
March 22, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905927/characteristics-and-outcomes-of-diabetic-patients-with-an-implantable-cardioverter-defibrillator-in-a-real-world-setting-results-from-the-israeli-icd-registry
#15
Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z Fisman, Gregory Golovchiner, Boris Strasberg, Alon Barsheshet
AIMS: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the outcome of appropriate and inappropriate ICD therapy in patients with or without DM. METHODS AND RESULTS: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry...
December 1, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27905653/-perceptions-of-faculty-members-and-students-about-undergraduate-training-in-primary-health-care
#16
Mario Parada-Lezcano, María Inés Romero S, Fabián Moraga Cortés
BACKGROUND: It is unknown if medical education is preparing physicians to successfully work at primary health care settings. AIM: To explore what are the perceptions of faculty members and students about the type of physician needed and if medical education is coherent with the practice of primary health care. MATERIAL AND METHODS: Fifteen semi-structured interviews to key informants from faculty members and ten focus groups with students were carried out...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27905597/mechanism-for-the-enhanced-oxygen-reduction-reaction-of-la0-6sr0-4co0-2fe0-8o3-%C3%AE-by-strontium-carbonate
#17
Mei Li, Zhongti Sun, Wenqiang Yang, Tao Hong, Zhesheng Zhu, Yanxiang Zhang, Xiaojun Wu, Changrong Xia
Strontium doped lanthanum cobalt ferrite (LSCF) is a widely applied electrocatalyst for the oxygen reduction reaction (ORR) in solid-oxide fuel cells (SOFCs) operated at intermediate temperatures. Sr surface segregation in long-term operation has been reported to have contradicting effects that either degrade or improve the reaction. Thus, it is critical to understand the mechanism of surface Sr compounds on ORR kinetics. This work aims to verify the effect and propose the mechanism by decorating SrCO3 nanoparticles using the infiltration method...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27905575/protoporphyrin-ix-modified-chitosan-g-oligo-nipaam-polymeric-micelles-from-physical-stabilization-to-permeability-characterization-in-vitro
#18
Inbar Schlachet, Alejandro Sosnik
Two main hurdles persist towards the more extensive bench-to-bed side translation of non-parenteral polymeric micelles. The first pertains to their thermodynamically-driven disassembly under uncontrolled dilution conditions in the biological milieu and upon interaction with biomacromolecules (e.g., proteins). The second is related to the relatively poor understanding of the pathways by which polymeric micelles improve the bioavailability of the payload by mucosal routes (e.g., intestinal). In this work, a chitosan-g-oligo(N-isopropylacrylamide) (CS-g-oligo(NiPAAm)) copolymer was modified with non-cytotoxic amounts of protoporphyrin IX (PP), a planar molecule of amphiphilic character that undergoes self-aggregation in water by forming π-π stacked supramolecular structures, to induce micellization under disfavored conditions and to serve as a fluorescent tracer for the measurement of the micelle permeability across a model of the intestinal epithelium in vitro...
December 1, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27905524/insights-into-the-competing-mechanisms-and-origin-of-enantioselectivity-for-n-heterocyclic-carbene-catalyzed-reaction-of-aldehyde-with-enamide
#19
Yan Qiao, Xinhuan Chen, Donghui Wei, Junbiao Chang
Hydroacylation reactions and aza-benzoin reactions have attracted considerable attention from experimental chemists. Recently, Wang et al. reported an interesting reaction of N-heterocyclic carbene (NHC)-catalyzed addition of aldehyde to enamide, in which both hydroacylation and aza-benzoin reactions may be involved. Thus, understanding the competing relationship between them is of great interest. Now, density functional theory (DFT) investigation was performed to elucidate this issue. Our results reveal that enamide can tautomerize to its imine isomer with the assistance of HCO3(-)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905521/evaluation-of-a-silicon-90-sr-betavoltaic-power-source
#20
Jefferson Dixon, Aravindh Rajan, Steven Bohlemann, Dusan Coso, Ajay D Upadhyaya, Ajeet Rohatgi, Steven Chu, Arun Majumdar, Shannon Yee
Betavoltaic energy converters (i.e., β-batteries) are attractive power sources because of their potential for high energy densities (>200 MWh/kg) and long duration continuous discharge (>1 year). However, conversion efficiencies have been historically low (<3%). High efficiency devices can be achieved by matching β-radiation transport length scales with the device physics length scales. In this work, the efficiency of c-Si devices using high-energy (>1 MeV) electrons emitted from (90)Sr as a power source is investigated...
December 1, 2016: Scientific Reports
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