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Tpn liver dysfunction

Shun Onishi, Tatsuru Kaji, Waka Yamada, Kazuhiko Nakame, Tomoe Moriguchi, Koushirou Sugita, Koji Yamada, Takafumi Kawano, Motoi Mukai, Masakazu Souda, Sohsuke Yamada, Takako Yoshioka, Akihide Tanimoto, Satoshi Ieiri
PURPOSE: Long-term parenteral nutrition following massive bowel resection causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). IFALD includes two different states, cholestasis and steatosis, which represents a life-threatening complication. The previous reports have shown the protective role of ghrelin in the liver. The aim of this study was to evaluate the effects of the administration of ghrelin in the liver in a parenterally fed rat model of short bowel syndrome (SBS)...
September 20, 2016: Pediatric Surgery International
Jai-Jen Tsai, Hsing-Chun Kuo, Kam-Fai Lee, Tung-Hu Tsai
Total parenteral nutrition (TPN) is provided as the primary nitrogen source to manage patients with intestinal failure who were not able to sustain themselves on enteral feeds. The most common complication of long-term TPN use is hepatitis. A proteomic approach was used to identify proteins that are differentially expressed in the plasma of rats following TPN-related acute liver injury. Six male rats were randomly assigned to either the saline infusion control group or the TPN infusion group. Our results demonstrate that TPN infusion in rats resulted in hepatic dysfunction and hepatocyte apoptosis...
November 2015: Proteomics
Xueping Zhu, Zhihui Xiao, Xiaoqian Chen, Yanhong Li, Xiaomin Zhang, Yumin Xu, Xing Feng, Jian Wang
OBJECTIVE: Parenteral nutrition in infants with gastrointestinal disorders can be lifesaving, but it is also associated with parenteral nutrition-associated liver disease. We investigated the effects of incorporating ω-3 fish oil in a parenteral nutrition mixture on signs of parenteral nutrition-associated liver disease and explored the mechanism involved in this process. METHODS: Seven-day-old New Zealand rabbits were divided into 3 groups of 8, and for 1 week they were infused via the right jugular vein with standard total parenteral nutrition with soybean oil (TPN-soy) or TPN with ω-3 fish oil-based lipid emulsion (TPN-FO), or naturally nursed with rabbit milk (control)...
December 2014: Journal of Pediatric Gastroenterology and Nutrition
A Drolz, T Horvatits, K Roedl, V Fuhrmann
Liver dysfunction is frequently observed in critically ill patients. Its occurrence is associated with high morbidity and mortality. The most frequent entities of hepatic dysfunction in the intensive care unit are shock liver and cholestatic liver dysfunction with incidence rates up to 10 and 30 %, respectively.Both conditions are frequently triggered by hypoxic and/or ischemic events, most commonly cardiogenic shock and sepsis/septic shock. However, several other potential contributors have been identified especially for cholestatic liver dysfunction...
May 2014: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Ning-Ning Li, Yong Zhou, Xian-Peng Qin, Yi Chen, Dan He, Jin-Yan Feng, Xiao-Ting Wu
BACKGROUND AND AIMS: Supplementation of fish oil (FO) containing lipid emulsions has been associated with a reduction in the length of hospital stay, infections and liver dysfunction in patients undergoing major surgery. We carried out a meta-analysis and subgroup analysis to examine randomised clinical trial (RCT)-based evidence of the aforementioned effects. METHODS: Four databases, reference lists and the WHO ICTRP were systematically searched for RCTs to access the clinical efficacy of fish oil-enriched total parenteral nutrition in post-surgery patients...
April 2014: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Jai-Jen Tsai, Hsing-Chun Kuo, Kam-Fai Lee, Tung-Hu Tsai
Total parenteral nutrition (TPN) is an artificial way to support daily nutritional requirements by bypassing the digestive system, but long-term TPN administration may cause severe liver dysfunction. Glycyrrhizin is an active component of licorice root that has been widely used to treat chronic hepatitis. The aim of this study is to investigate the hepatoprotective effect of glycyrrhizin on TPN-associated acute liver injury in vivo. Liver dysfunction was induced by intravenous infusion of TPN at a flow rate of 20 mL/kg/h for three h in Sprague Dawley rats...
2013: International Journal of Molecular Sciences
A S Barbas, A S Rege, A W Castleberry, J Gommer, M J Ellis, T V Brennan, B H Collins, A E Martin, K V Ravindra, D S Vikraman, D L Sudan
Posterior reversible encephalopathy syndrome (PRES) is a small vessel microangiopathy of the cerebral vasculature that occurs in 0.5-5% of solid organ transplant recipients, most commonly associated with tacrolimus (Tac). Clinical manifestations include hypertension and neurologic symptoms. We report an adult multivisceral transplant recipient who experienced recurrent PRES initially associated with Tac and subsequently with sirolimus. A 49-year-old woman with short bowel syndrome underwent multivisceral transplantation due to total parenteral nutrition-related liver disease...
March 2013: American Journal of Transplantation
Karen D Corbin, Steven H Zeisel
PURPOSE OF REVIEW: Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans are deprived of choline. In the last few years, there have been significant advances in our understanding of the mechanisms that influence choline requirements in humans and in our understanding of choline's effects on liver function. These advances are useful in elucidating why nonalcoholic fatty liver disease (NAFLD) occurs and progresses sometimes to hepatocarcinogenesis...
March 2012: Current Opinion in Gastroenterology
G Kobbe, A Heyll, T Zodler, D Sohngen, C Aul, K Thiele, U Germing, W Schneider
Acalculous cholecystitis (AAC) is a well known complication in critically ill patients. Risk factors include mechanical ventilation, total parenteral nutrition and multiple blood transfusions. AAC has very rarely been described in patients undergoing allogeneic BMT. We report a case of AAC in a 25-year old female occuring after successful allografting for acute myeloid leukemia. The patient presented with leukocytosis, acute abdominal pain, right upper quadrant guarding and laboratory signs of liver dysfunction coincidentally with oral recontamination 38 days after BMT...
July 1997: Oncology Reports
E R S Clore, L M Freeman, D Bedenice, C A Tony Buffington, D E Anderson
BACKGROUND: Parenteral nutrition is an important method of nutritional support in hospitalized animals, but minimal information has been published on its use in camelids. HYPOTHESIS/OBJECTIVES: The purpose of this study was to characterize the use of total parenteral nutrition (TPN) in alpacas, evaluate the formulations used, and determine potential complications. ANIMALS: Twenty-two alpacas hospitalized at the Tufts Cummings School for Veterinary Medicine (site 1: n = 8) and the Ohio State University Veterinary Teaching Hospital (site 2: n = 14)...
May 2011: Journal of Veterinary Internal Medicine
Andrew Aronsohn, Donald Jensen
Liver dysfunction is common in both the critically ill and postoperative patient. Metabolic derangements secondary to sepsis, poor hepatic perfusion, total parenteral nutrition, in addition to hemodynamic and anesthetic-induced changes that occur during surgery, can cause liver damage ranging from small self-limited abnormalities in liver chemistries to acute liver failure. Early recognition, supportive care, and effective treatment of the underlying disease process are crucial steps in managing liver disease in a critically ill patient...
February 2011: Clinics in Liver Disease
Barbara Stoll, David A Horst, Liwei Cui, Xiaoyan Chang, Kenneth J Ellis, Darryl L Hadsell, Agus Suryawan, Ashish Kurundkar, Akhil Maheshwari, Teresa A Davis, Douglas G Burrin
Prematurity and overfeeding in infants are associated with insulin resistance in childhood and may increase the risk of adult disease. Total parenteral nutrition (TPN) is a major source of infant nutritional support and may influence neonatal metabolic function. Our aim was to test the hypothesis that TPN induces increased adiposity and insulin resistance compared with enteral nutrition (EN) in neonatal pigs. Neonatal pigs were either fed enteral formula orally or i.v. administered a TPN mixture for 17 d; macronutrient intake was similar in both groups...
December 2010: Journal of Nutrition
Hirokazu Arai, Atsuko Noguchi, Ryoji Goto, Takefumi Matsuda, Hatsushi Nakajima, Tsutomu Takahashi
Premature infants with intrauterine growth restriction (IUGR) are at greater risk for an adverse perinatal outcome. IUGR affects hepatocyte function, but the histopathological changes in the postnatal liver are not well known. We report a male infant with severe IUGR. His mother was transferred to our hospital at 26 weeks of gestation because of preterm labor and severe IUGR. An emergency cesarean section was carried out because of a non-reassuring fetal status. The birth weight of the infant was 332 g. He showed congestive heart failure and marked hepatomegaly from birth...
July 2010: Tohoku Journal of Experimental Medicine
Ying Wang, Ye-Xuan Tao, Wei Cai, Qing-Ya Tang, Yi Feng, Jiang Wu
BACKGROUND & AIMS: Hepatic dysfunction is one of the most frequent complications of parenteral nutrition. Very low birth weight (VLBW) infants are more sensitive to liver injury due to physiological immaturity. Our studies in animals showed that glutamine supplementation could attenuate TPN-associated liver injury. The aim of study was to investigate whether parenteral glutamine supplementation can improve hepatic tolerance in VLBW infants. METHODS: We performed a double-blind, randomized, and controlled clinical study to investigate whether parenteral glutamine supplementation can improve hepatic tolerance in VLBW infants...
June 2010: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Cüneyt Günşar, Seda Vatansever, Ahmet Var, Reha Aygören, Omer Yilmaz, Elgin Türköz, Aydin Sencan, Erol Mir
PURPOSE: This study aimed to investigate the apoptotic mechanisms, oxidative stress, and mechanisms of effect of antibiotics and ursodeoxycholic acid (UDCA) in total parenteral nutrition (TPN)-associated liver injury. METHODS: Four groups of young rabbits were used in the study as follows: Group 1 (n: 7): TPN + Metronidazole (30 mg/kg IV) + Gentamicin (6 mg/kg IV); Group 2 (n: 7): TPN + UDCA (15 mg/kg per oral); Group 3 (n: 6): TPN only; and Group 4 (n: 7): Control group...
May 2010: Pediatric Surgery International
Feng Ji, Jing-Li Zhao, Xi Jin, Chun-Hua Jiao, Yu-Yao Hu, Qin-Wei Xu, Wei-Xing Chen
BACKGROUND: Total parenteral nutrition (TPN) has been recognized as the mainstay of nutritional support in patients with severe hepatopancreatobiliary (HPB) diseases for decades. However, recent studies advocate the utilization of endoscopic nasojejunal feeding tube placement (ENFTP), rather than the conventional approach. This study was designed to compare the clinical value of ENFTP and TPN in patients with severe HPB diseases. METHODS: Two groups of patients with severe HPB diseases were analyzed retrospectively...
February 2010: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Li Hong, Xiang Wang, Jiang Wu, Wei Cai
PURPOSE: The aim of the study was to investigate oxidative injury and apoptosis as the mechanisms underlying total parenteral nutrition (TPN)-associated liver dysfunction. METHODS: Twenty New Zealand rabbits (2 weeks old) were divided into 2 groups as follows: 10 in the control group (maternal feed) and 10 in the TPN group. The rabbits in the TPN group received continuous PN infusion through a silastic catheter inserted in the right jugular vein. RESULTS: After 10 days of treatment, the serum levels of total bilirubin and bile acid were significantly higher in the TPN group than in the control group (P < ...
September 2009: Journal of Pediatric Surgery
Heike von Rettberg, Torsten Hannman, Ulrike Subotic, Joachim Brade, Thomas Schaible, Karl Ludwig Waag, Steffan Loff
INTRODUCTION: Most polyvinylchloride infusion systems are plasticized with up to 60% of di(2-ethylhexyl)phthalate (DEHP). DEHP is easily extracted from the tubing by total parenteral nutrition (TPN) solutions and has been shown to have toxic effects on various organ systems including the liver in animals and humans. A role was postulated for DEHP in the development of hepatobiliary dysfunction in premature and newborn infants receiving parenteral nutrition, and the incidence of cholestasis was investigated after changing from polyvinylchloride infusion systems to polyvinylchloride-free infusion systems...
August 2009: Pediatrics
Yuko Tazuke, Daniel H Teitelbaum
OBJECTIVES: Parenteral nutrition-associated liver disease (PNALD) is a major problem with prolonged total parenteral nutrition (TPN) administration. Our laboratory previously demonstrated significant changes in the expression of multidrug resistance genes (MDRs) 1 and 2, hepatocyte transporters, in a TPN mouse model. The present study hypothesized that these changes would lead to functional changes in the liver, and would contribute to the development of liver dysfunction. MATERIALS AND METHODS: Mice received either intravenous saline and standard chow or TPN with or without intravenous lipids...
February 2009: Journal of Pediatric Gastroenterology and Nutrition
George V Mazariegos, Kyle Soltys, Geoffrey Bond, Alin Girnita, Zurab Machaidze, Ronald Jaffe, Michael Green, Dolly Martin, Adriana Zeevi, Robert Squires, Graciela Perez, Kareem Abu-Elmagd, Rakesh Sindhi
BACKGROUND: Intestinal retransplantation (Re-ITx) has historically been associated with high morbidity and mortality. METHODS: The outcomes of all children receiving Re-ITx between 1990 and 2007 at our center were reviewed. RESULTS: One hundred seventy-two children received primary intestinal grafts. Fourteen children (8.1%) were retransplanted with 15 grafts. Causes of graft failure were acute cellular rejection (ACR, n=4), liver failure (n=2), chronic rejection (n=3), posttransplant lymphoproliferative disorder (n=1), graft dysmotility or dysfunction (n=3), ACR with severe infection (n=1), and arterial graft aneurysm (n=1)...
December 27, 2008: Transplantation
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