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https://www.readbyqxmd.com/read/28749622/understanding-and-challenges-in-taking-tyrosine-kinase-inhibitors-among-malaysian-chronic-myeloid-leukemia-patients-a-qualitative-study
#1
Yik Ming Lim, Wei Lerk Eng, Huan Keat Chan
Background: In Malaysia, the treatment for chronic myeloid leukemia (CML) has long been delivered under the Malaysian Patient Assistance Program (MYPAP), but research on identifying factors contributing to non-adherence to tyrosine kinase inhibitors (TKIs) is still limited. The current study explored understanding and challenges of Malaysian CML patients in taking imatinib and nilotinib. Methods: Semi-structured, face-to-face interviews were conducted with 13 CML patients receiving treatment at a public tertiary care center, and were analyzed using the content analysis approach...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749599/heat-induced-inflammation-and-its-role-in-esophageal-cancer
#2
REVIEW
Mohaddese Maghsudlu, Ehsan Farashahi Yazd
Esophageal cancer as the sixth common cause of cancer death in the world consists of different histological types with various incidence patterns. Among them, esophageal adenocarcinoma and esophageal squamous cell carcinoma are the most prevalent types which also have different causality, cell of origin and risk factors. Since epidemiological studies have announced consumption of hot substances as one of the major risk factors for squamous cell carcinoma, evaluating the effect of this external stress on esophagus cells seems desirable...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28749586/patient-decisions-to-receive-secondary-pharmacogenomic-findings-and-development-of-a-multidisciplinary-practice-model-to-integrate-results-into-patient-care
#3
J Kevin Hicks, Amy Shealy, Allison Schreiber, Marissa Coleridge, Ryan Noss, Marvin Natowicz, Rocio Moran, Timothy Moss, Angelika Erwin, Charis Eng
Whole exome sequencing (WES) has the potential of identifying secondary findings that are predictive of poor pharmacotherapy outcomes. The purpose of this study was to investigate patients' wishes regarding the reporting of secondary pharmacogenomic findings. WES results (n = 106 patients) were retrospectively reviewed to determine the number of patients electing to receive secondary pharmacogenomic results. Phenotypes were assigned based on Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines...
July 27, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28749532/contracted-schr%C3%A3-dinger-equation-in-quantum-phase-space
#4
Carol Frishberg, Leon Cohen
The phase space formulation of quantum mechanics is equivalent to standard quantum mechanics where averages are calculated by way of phase space integration as in the case of classical statistical mechanics. We derive the quantum hierarchy equations, often called the contracted Schrödinger equation, in the phase space representation of quantum mechanics which involves quasi-distributions of position and momentum. We use the Wigner distribution for the phase space function and the Moyal phase space eigenvalue formulation to derive the hierarchy...
July 27, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28749520/photocurrent-spectroscopy-of-dye-sensitized-carbon-nanotubes
#5
Asiful Alam, Simone Dehm, Frank Hennrich, Yuriy Zakharko, Arko Graf, Moritz Pfohl, Ihteaz M Hossain, Manfred M Kappes, Jana Zaumseil, Ralph Krupke, Benjamin S Flavel
Monochiral (7,5) single walled carbon nanotubes (SWCNTs) are integrated into a field effect transistor device in which the built-in electric field at the nanotube/metal contact allows for exciton separation under illumination. Variable wavelength spectroscopy and 2D surface mapping of devices consisting of 10-20 nanotubes are performed in the visible region and a strong correlation between the nanotube's second optical transition (S22) and the photocurrent is found. After integration, the SWCNTs are non-covalently modified with three different fluorescent dye molecules with off-resonant absorption maxima at 532 nm, 565 nm, and 610 nm...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749426/a-novel-perspective-on-the-apom-s1p-axis-highlighting-the-metabolism-of-apom-and-its-role-in-liver-fibrosis-and-neuroinflammation
#6
REVIEW
Stefan Hajny, Christina Christoffersen
Hepatocytes, renal proximal tubule cells as well as the highly specialized endothelium of the blood brain barrier (BBB) express and secrete apolipoprotein M (apoM). ApoM is a typical lipocalin containing a hydrophobic binding pocket predominantly carrying Sphingosine-1-Phosphate (S1P). The small signaling molecule S1P is associated with several physiological as well as pathological pathways whereas the role of apoM is less explored. Hepatic apoM acts as a chaperone to transport S1P through the circulation and kidney derived apoM seems to play a role in S1P recovery to prevent urinal loss...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749424/drug-discovery-by-molecular-imaging-and-monitoring-therapy-response-in-lymphoma
#7
REVIEW
Senthilkumar Kalimuthu, Ju Hye Jeong, Ji Min Oh, Byeong-Cheol Ahn
Molecular imaging allows a noninvasive assessment of biochemical and biological processes in living subjects. Treatment strategies for malignant lymphoma depend on histology and tumor stage. For the last two decades, molecular imaging has been the mainstay diagnostic test for the staging of malignant lymphoma and the assessment of response to treatment. This technology enhances our understanding of disease and drug activity during preclinical and clinical drug development. Here, we review molecular imaging applications in drug development, with an emphasis on oncology...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749422/metamaterials-and-metasurfaces-for-sensor-applications
#8
REVIEW
Yohan Lee, Sun-Je Kim, Hyeonsoo Park, Byoungho Lee
Electromagnetic metamaterials (MMs) and metasurfaces (MSs) are artificial media and surfaces with subwavelength separations of meta-atoms designed for anomalous manipulations of light properties. Owing to large scattering cross-sections of metallic/dielectric meta-atoms, it is possible to not only localize strong electromagnetic fields in deep subwavelength volume but also decompose and analyze incident light signal with ultracompact setup using MMs and MSs. Hence, by probing resonant spectral responses from extremely boosted interactions between analyte layer and optical MMs or MSs, sensing the variation of refractive index has been a popular and practical application in the field of photonics...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749389/starting-the-conversation-integrating-mental-health-into-maternal-health-care-in-india
#9
Ashlesha Bagadia, Prabha S Chandra
No abstract text is available yet for this article.
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28749374/nitrogen-doped-rgo-co3o4-nanograin-cookies-highly-porous-and-robust-catalyst-for-removing-nitrophenol-from-waste-water
#10
Erum Pervaiz, Muhammad Syam Azher Virk, Zhang Bingxue, Congling Yin, Minghui Yang
Fabrication of nanograins with uniform morphology wrapped with reduced graphene oxide (RGO) in a designed fashion is critical for obtaining large surface, high porosity and efficient catalytic ability at mild conditions. Hybrid structures of metal oxides decorated on two dimensional (2D) RGO lacked interface and channels between individual grains and RGO. Present work merely focused the synthesis of RGO wrapped Co3O4 nanograins architecture in micron sized polyhedrons and the ability of reducing aromatic nitro compounds...
July 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28749363/distributed-parametric-consensus-optimization-with-an-application-to-model-predictive-consensus-problem
#11
Xinli Shi, Jinde Cao, Wei Huang
In this paper, we study a special class of distributed convex optimization problems--distributed parametric consensus optimization problem (DPCOP), for which a two-stage optimization method including primal decomposition and distributed consensus is provided. Different from traditional distributed optimization problems driving all the local states to a common value, DPCOP aims to solve a system-wide problem with partial common parameters shared amongst local agents in a distributed way. To relax the restriction on the topology, a distributed projected subgradient method is applied in distributed consensus stage to achieve the consensus of local estimated parameters, while the subgradients can be obtained by solving a multiparametric problem locally...
July 25, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28749360/multi-hypergraph-learning-for-incomplete-multi-modality-data
#12
Mingxia Liu, Yue Gao, Pew-Thian Yap, Dinggang Shen
Multi-modality data convey complementary information that can be used to improve the accuracy of prediction models in disease diagnosis. However, effectively integrating multi-modality data remains a challenging problem especially when the data are incomplete. For instance, more than half of the subjects in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database have no fluorodeoxyglucose positron emission tomography (FDG-PET) and cerebrospinal fluid (CSF) data. Currently, there are two commonly-used strategies to handle the problem of incomplete data: 1) discard samples having missing features, and 2) impute those missing values via specific techniques...
July 26, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28749359/systolic-time-interval-estimation-using-continuous-wave-radar-with-on-body-antennas
#13
Dilpreet Buxi, Evelien Hermeling, Marco Mercuri, Fabian Beutel, Roberto Garcia van der Westen, Tom Torfs, Jean-Michel Redoute, Mehmet Rasit Yuce
The estimation of systolic time interval (STI)s is done using continuous wave (CW) radar at 2.45GHz with an on-body antenna. MOTIVATION: In the state of the art, typically bioimpedance, heart sounds and / or ultrasound is used to measure STIs. All three methods suffer from insufficient accuracy of STI estimation due to various reasons. CW radar is investigated for its ability to overcome the deficiencies in the state of the art. METHODS: Ten healthy male subjects aged 25-45 were asked to lie down at a 30 degree incline...
July 25, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28749344/giant-magnetoresistive-biosensor-array-for-detecting-magnetorelaxation
#14
Xiahan Zhou, Chih-Cheng Huang, Drew A Hall
In this paper, a time-domain magnetorelaxometry biosensing scheme is presented using giant magnetoresistive (GMR) sensors to measure the fast relaxation response of superparamagnetic magnetic nanoparticles (MNPs) in a pulsed magnetic field. The system consists of an 8 × 10 GMR sensor array, a Helmholtz coil, an electromagnet driver, and an integrator-based analog front-end needed to capture the fast relaxation dynamics of MNPs. A custom designed electromagnet driver and Helmholtz coil improve the switch-off speed to >5 Oe/μs, limiting the dead zone time to <10 μs, and thus enables the system to monitor fast relaxation processes of 30 nm MNPs...
August 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28749326/pneumococcal-neuraminidase-activates-tgf-%C3%AE-signalling
#15
Nina Gratz, Lip Nam Loh, Beth Mann, Geli Gao, Robert Carter, Jason Rosch, Elaine I Tuomanen
Neuraminidase A (NanA) is an important virulence factor that is anchored to the pneumococcal cell wall and cleaves sialic acid on host substrates. We noted that a secreted allele of NanA was over-represented in invasive pneumococcal isolates and promoted the development of meningitis when swapped into the genome of non-meningitis isolates replacing cell wall-anchored NanA. Both forms of recombinant NanA directly activated transforming growth factor (TGF)-β, increased SMAD signalling and promoted loss of endothelial tight junction ZO-1...
July 28, 2017: Microbiology
https://www.readbyqxmd.com/read/28749322/integration-of-slack-a-cloud-based-team-collaboration-application-into-research-coordination
#16
Miriam Gofine, Sunday Clark
Practitioners of epidemiology require efficient real-time communication and shared access to numerous documents in order to effectively manage a study. Much of this communication involves study logistics and does not require use of Protected Health Information. Slack is a team collaboration app; it archives all direct messages and group conversations, hosts documents internally, and integrates with the Google Docs application. Slack has both desktop and mobile applications, allowing users to communicate in real-time without the need to find email addresses or phone numbers or create contact lists...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749321/design-and-implementation-of-an-affordable-public-sector-electronic-medical-record-in-rural-nepal
#17
Anant Raut, Chase Yarbrough, Vivek Singh, Bikash Gauchan, David Citrin, Varun Verma, Jessica Hawley, Dan Schwarz, Alex Harsha Bangura, Biplav Shrestha, Ryan Schwarz, Mukesh Adhikari, Duncan Maru
INTRODUCTION: Globally, electronic medical records are central to the infrastructure of modern healthcare systems. Yet the vast majority of electronic medical records have been designed for resource-rich environments and are not feasible in settings of poverty. Here we describe the design and implementation of an electronic medical record at a public sector district hospital in rural Nepal, and its subsequent expansion to an additional public sector facility.DevelopmentThe electronic medical record was designed to solve for the following elements of public sector healthcare delivery: 1) integration of the systems across inpatient, surgical, outpatient, emergency, laboratory, radiology, and pharmacy sites of care; 2) effective data extraction for impact evaluation and government regulation; 3) optimization for longitudinal care provision and patient tracking; and 4) effectiveness for quality improvement initiatives...
June 23, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749251/identification-of-spirocyclic-or-phosphate-substituted-quinolizine-derivatives-as-novel-hiv-1-integrase-inhibitors-a-patent-evaluation-of-wo2016094197a1-wo2016094198a1-and-wo2016154527a1
#18
Xiqiang Cheng, Ping Gao, Lin Sun, Ye Tian, Peng Zhan, Xinyong Liu
Highly active antiretroviral therapy (HAART) has been widely adopted to control the HIV-1 infection successfully. HIV-1 integrase (IN) inhibitors are primary drugs in HAART regimens targeting integration step in the HIV-1 life cycle. However, due to the emergence of viral resistance and cross-resistance amongst drugs, there is a pressing need for new and potent IN inhibitors. This review covers the three patents describing spirocyclic and phosphate substituted quinolizine derivatives as novel HIV-1 IN inhibitors for the discovery of new anti-HIV-1 drug candidates...
July 27, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28749248/update-in-perioperative-medicine-practice-changing-evidence-published-in-2016
#19
Dennis W Regan, Deanne Kashiwagi, Brian Dougan, Karna Sundsted, Karen Mauck
This summary reviews 18 key articles published in 2016 which have significant practice implications for the perioperative medical care of surgical patients. Due to the multi-disciplinary nature of the practice of perioperative medicine, important new evidence is published in journals representing a variety of medical and surgical specialties. Keeping current with the evidence that drives best practice in perioperative medicine is therefore challenging. We set out to identify, critically review, and summarize key evidence which has the most potential for practice change...
July 27, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28749247/evaluating-the-effectiveness-of-a-community-based-hygiene-promotion-program-in-a-rural-salvadoran-setting
#20
Elizabeth L Andrade, Jeffrey B Bingenheimer, Mark C Edberg, Kathryn L Zoerhoff, Emily M Putzer
There has been considerable progress in the reduction of diarrheal disease among children under five through health and nutrition interventions. However, diarrheal disease is still the second leading cause of child death worldwide. There is growing recognition that comprehensive hygiene behavior improvements should be integral to prevention efforts, but the effectiveness of different approaches for hygiene promotion is still being established. Hygiene risk practices vary across settings, suggesting that prevention strategies should be adapted to local contexts using community-based approaches...
July 1, 2017: Global Health Promotion
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