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Konstantinos S Mylonas, Dimitrios Nasioudis, Diamantis I Tsilimigras, Ilias P Doulamis, Peter T Masiakos, Cassandra M Kelleher
PURPOSE: To examine the clinicopathological characteristics and prognosis of pediatric patients with malignant pancreatic tumors in a population-based cohort. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify all pediatric patients with malignant pancreatic tumors, diagnosed between 1973 and 2013. Kaplan-Meier analysis was performed to determine median and five-year overall survival (OS) rates. Univariate survival analysis was executed using the log-rank test...
June 30, 2017: Journal of Pediatric Surgery
Souji Ibuka, Shuichiro Uehara, Takehisa Ueno, Takaharu Oue, Takako Miyamura, Yoshiko Hashii, Hiroomi Okuyama
BACKGROUND: As no standard chemotherapy exists for pancreatoblastoma (PB), surgical resection is the most effective way of achieving complete remission. CASE REPORT: A 3-year-old girl with PB causing portal vein obstruction was referred to our hospital. Because of the portal vein involvement, she initially received 5 cycles of preoperative chemotherapy after biopsy, consisting of cyclophosphamide, vincristine, pirarubicin, and cisplatin. After chemotherapy, she underwent distal pancreatectomy, and the tumor was resected completely...
May 22, 2017: Journal of Pediatric Hematology/oncology
Marisa Terino, Eileen Plotkin, Raffi Karagozian
No abstract text is available yet for this article.
February 14, 2017: Journal of Gastrointestinal Cancer
Sun-Young Jun, Seung-Mo Hong
Nonductal pancreatic neoplasms, including solid pseudopapillary neoplasms, acinar cell carcinomas, and pancreatoblastomas, are uncommon. These entities share overlapping gross, microscopic, and immunohistochemical features, such as well-demarcated solid neoplasms, monotonous cellular tumor cells with little intervening stroma, and abnormal beta-catenin expression. Each tumor also has unique clinicopathologic characteristics with diverse clinical behavior. To differentiate nonductal pancreatic neoplasms, identification of histologic findings, such as pseudopapillae, acinar cell features, and squamoid corpuscles, is important...
December 2016: Surgical Pathology Clinics
Erika B Lindholm, Abdulaziz K Alkattan, Sara J Abramson, Anita P Price, Todd E Heaton, Vinod P Balachandran, Michael P La Quaglia
PURPOSE: While pancreaticoduodenectomy (PD) has been extensively studied in adults, there are few data pertaining specifically to pediatric patients. We retrospectively analyzed PD-associated morbidity and mortality in pediatric patients. METHODS: Our analytic cohort included all consecutive patients ≤18years of age treated at our institution from 1993 to 2015 who underwent PD. Patient data (demographics, disease characteristics, surgical and adjuvant treatment, length of hospital stay, and postoperative course) were extracted from the medical records...
February 2017: Journal of Pediatric Surgery
Filipa Vilaverde, Alcinda Reis, Pedro Rodrigues, Ana Carvalho, Horácio Scigliano
Most cases of pancreatoblastoma, a rare malignant epithelial tumor of the pancreas, are seen in the pediatric population. The rarity of pancreatoblastoma, the similar radiologic findings to those seen in other pancreatic lesions, and its histopathologic heterogeneity, make its preoperative diagnosis in adults a real challenge. We report ultrasound, computed tomography and magnetic resonance imaging correlative findings of a histologically proven pancreatoblastoma in a 37-year-old woman. Pancreatoblastoma should be considered in the differential diagnosis of a pancreatic mass presenting uncommon imaging features...
August 2016: Journal of Radiology Case Reports
R Girlanda, A Pozzi, C S Matsumoto, T M Fishbein
Organ transplantation in patients with prior malignancy increases the risk of tumor recurrence post-transplantation due to immunosuppression. Only two cases of liver transplantation have so far been reported in children with hepatic metastases from pancreatoblastoma, a rare malignant neoplasm originating from the epithelial exocrine cells of the pancreas. Herein, we describe a case of a successful multi-visceral transplant in a man with intestinal failure after surgical resection of pancreatoblastoma.
2016: International Journal of Organ Transplantation Medicine
Maria G Sacco Casamassima, Colin D Gause, Seth D Goldstein, Fizan Abdullah, Avner Meoded, Jeffrey R Lukish, Christopher L Wolfgang, John Cameron, David J Hackam, Ralph H Hruban, Paul M Colombani
PURPOSE: Pancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies. METHODS: We conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent surgery at a single institution between 1995 and 2015. RESULTS: Nineteen patients were identified with a median age at operation of 16...
August 2016: Pediatric Surgery International
David S Klimstra, Volkan Adsay
Our understanding about the family of acinar neoplasms of the pancreas has grown substantially over the past 25 years. The prototype is acinar cell carcinoma, an uncommon variant of pancreatic carcinoma that demonstrates production of pancreatic exocrine enzymes, verifiable using immunohistochemistry, and exhibits characteristic histologic features. Related neoplasms include mixed acinar carcinomas such as mixed acinar neuroendocrine carcinoma and mixed acinar ductal carcinoma. In the pediatric age group, pancreatoblastoma is also closely related...
September 2016: Seminars in Diagnostic Pathology
Wenzel M Hackeng, Ralph H Hruban, G Johan A Offerhaus, Lodewijk A A Brosens
BACKGROUND: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. MAIN BODY: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment...
June 7, 2016: Diagnostic Pathology
Pankaj Halder, Bedabrata Mukhopadhyay, Chhanda Das, Madhumita Mukhopadhyay
Pancreatoblastoma, is rare exocrine malignant tumour of childhood. We are reporting a case of three-year-old child presented to our hospital suffering from vague abdominal pain for further examination and treatment. Clinical examination revealed only a palpable abdominal mass. CT Scan revealed a huge complex space occupying lesion 9.1x8.8x9.2cm with large central cystic degeneration and lobulated enhancing peripheral solid components with foci of calcification, seem to arise from body and tail regions of pancreas...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
Aruna Prabhu, Monica Bhagat, Mukta Ramadwar, Sajid S Qureshi
Clinicoradiological and histopathological differentiation of pancreatoblastoma from hepatoblastoma can often be a challenge in clinical practice owing to their peculiar resemblance. We report a case of a 4-year-old boy with a right hypochondriac region mass, which was diagnosed as hepatoblastoma on the basis of imaging, raised tumor marker, and biopsy; however, pancreatic origin of the mass was ascertained on exploration and pancreatoblastoma was confirmed on histopathology.
April 2016: Journal of Indian Association of Pediatric Surgeons
S Das, R Ghosh, A Sen, R N Das, K Saha, U Chatterjee
No abstract text is available yet for this article.
December 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
Anan Zhang, Jingyan Tang, Shan Wang, Xiaofei Sun, Xiaoli Ma, Ci Pan
OBJECTIVE: To analyze clinical features, outcomes and correlative prognostic factors of the disease. METHOD: Totally 14 newly diagnosed children with pancreatoblastoma at Shanghai Children's Medical Center, Children's Hospital of Chongqing Medical University, Sun Yat-sen University Cancer Center and Beijing Children's Hospital were enrolled into this study between April 2003 and July 2013. The clinical features, surgery, chemotherapy protocol and prognostic factors of patients were retrospectively analyzed...
January 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Elzbieta Drozynska, Ewa Bien, Katarzyna Polczynska, Joanna Stefanowicz, Beata Zalewska-Szewczyk, Ewa Izycka-Swieszewska, Anna Ploszynska, Malgorzata Krawczyk, Gabrielle Karpinsky
Protocols for pediatric germ cell tumors (GCT) allow for chemotherapy (CHT) initiation without histological diagnosis, based on typical clinical and radiological picture and increased alphafetoprotein (AFP) or beta-human chorionic gonadotropin serum levels. Such strategy may result in misdiagnoses in rare cases. We present two patients with abdominal tumors and high serum AFP levels, diagnosed as GCT. In both, no tumor shrinkage and increasing AFP was observed after first cycles of multidrug CHT for pediatric GCT...
2015: Biomarkers in Medicine
Ayodeji Oluwarotimi Omiyale
Pancreatoblastoma (PB) is a rare malignant neoplasm of the pancreas with unknown etiology. It occurs mostly in the pediatric population with very rare documented cases in adults. This is a review of the case reports of the adult pancreatoblastoma in the literature. A total of 35 cases were identified and reviewed with the mean age of 41 years (range, 18-78 years) and the male sex accounted for 51.4% of the cases. Adult Pancreatoblastoma seem to have a predilection for the head of the pancreas which accounted for approximately 49% of the cases reviewed with an average size of 8 cm (range, 1...
August 2015: Gland Surgery
Omar Nasher, Nigel J Hall, Neil J Sebire, Paolo de Coppi, Agostino Pierro
PURPOSE: Pancreatic tumours in children are exceedingly rare and as a result constitute a diagnostic and therapeutic challenge to paediatric surgeons. We reviewed our experience with these rare entities. METHODS: Retrospective single institution study on all paediatric pancreatic tumours over a period of 38 years (1973-2011) and literature review. We recorded data relating to the clinical features at presentation, diagnostic evaluation, treatment and outcome. RESULTS: Fourteen patients were identified (eight male)...
September 2015: Pediatric Surgery International
Efstratios Zouros, Dimitrios K Manatakis, Spiros G Delis, Christos Agalianos, Charina Triantopoulou, Christos Dervenis
The present study describes the case of a 24-year-old patient who presented with obstructive jaundice and weight loss, and was diagnosed with pancreatoblastoma (PB). Abdominal imaging studies revealed a heterogenous lesion of the pancreatic head with dilatation of the common bile duct. The patient underwent pancreaticoduodenectomy, however, three months after surgery multiple liver and bone metastases were identified on follow-up computed tomography scans. Despite treatment with four cycles of systemic chemotherapy and five courses of radiofrequency ablation, the patient succumbed due to tumour dissemination 13 months after initial diagnosis...
May 2015: Oncology Letters
Chetan Dhamne, Cynthia E Herzog
Pancreatoblastoma is a rare tumor of the pancreas in children, with favorable prognosis if completely resected. If unresectable, neoadjuvant chemotherapy with cisplatin-based regimens are commonly used with good response that allows for resection. For locally aggressive or metastatic disease, neoadjuvant chemotherapy has been reported. Treatment for relapsed or refractory cases is based on anecdotal experiences. We report 2 cases of relapsing pancreatoblastoma with clinical and radiologic response to vinorelbine and cyclophosphamide...
August 2015: Journal of Pediatric Hematology/oncology
Kenji Notohara
No abstract text is available yet for this article.
March 2015: Nihon Rinsho. Japanese Journal of Clinical Medicine
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