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Pancreatoblastoma

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https://www.readbyqxmd.com/read/27894759/pancreaticoduodenectomy-for-pediatric-and-adolescent-pancreatic-malignancy-a-single-center-retrospective-analysis
#1
Erika B Lindholm, Abdulaziz K Alkattan, Sara J Abramson, Anita P Price, Todd E Heaton, Vinod P Balachandran, Michael P La Quaglia
PURPOSE: While pancreaticoduodenectomy (PD) has been extensively studied in adults, there are few data pertaining specifically to pediatric patients. We retrospectively analyzed PD-associated morbidity and mortality in pediatric patients. METHODS: Our analytic cohort included all consecutive patients ≤18years of age treated at our institution from 1993 to 2015 who underwent PD. Patient data (demographics, disease characteristics, surgical and adjuvant treatment, length of hospital stay, and postoperative course) were extracted from the medical records...
November 16, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27761191/adult-pancreatoblastoma-case-report-and-review-of-literature
#2
Filipa Vilaverde, Alcinda Reis, Pedro Rodrigues, Ana Carvalho, Horácio Scigliano
Most cases of pancreatoblastoma, a rare malignant epithelial tumor of the pancreas, are seen in the pediatric population. The rarity of pancreatoblastoma, the similar radiologic findings to those seen in other pancreatic lesions, and its histopathologic heterogeneity, make its preoperative diagnosis in adults a real challenge. We report ultrasound, computed tomography and magnetic resonance imaging correlative findings of a histologically proven pancreatoblastoma in a 37-year-old woman. Pancreatoblastoma should be considered in the differential diagnosis of a pancreatic mass presenting uncommon imaging features...
August 2016: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/27721967/multi-visceral-transplantation-in-a-21-year-old-man-with-prior-pancreatoblastoma
#3
R Girlanda, A Pozzi, C S Matsumoto, T M Fishbein
Organ transplantation in patients with prior malignancy increases the risk of tumor recurrence post-transplantation due to immunosuppression. Only two cases of liver transplantation have so far been reported in children with hepatic metastases from pancreatoblastoma, a rare malignant neoplasm originating from the epithelial exocrine cells of the pancreas. Herein, we describe a case of a successful multi-visceral transplant in a man with intestinal failure after surgical resection of pancreatoblastoma.
2016: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/27364750/pancreatic-surgery-for-tumors-in-children-and-adolescents
#4
Maria G Sacco Casamassima, Colin D Gause, Seth D Goldstein, Fizan Abdullah, Avner Meoded, Jeffrey R Lukish, Christopher L Wolfgang, John Cameron, David J Hackam, Ralph H Hruban, Paul M Colombani
PURPOSE: Pancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies. METHODS: We conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent surgery at a single institution between 1995 and 2015. RESULTS: Nineteen patients were identified with a median age at operation of 16...
August 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27320062/acinar-neoplasms-of-the-pancreas-a-summary-of-25-years-of-research
#5
David S Klimstra, Volkan Adsay
Our understanding about the family of acinar neoplasms of the pancreas has grown substantially over the past 25 years. The prototype is acinar cell carcinoma, an uncommon variant of pancreatic carcinoma that demonstrates production of pancreatic exocrine enzymes, verifiable using immunohistochemistry, and exhibits characteristic histologic features. Related neoplasms include mixed acinar carcinomas such as mixed acinar neuroendocrine carcinoma and mixed acinar ductal carcinoma. In the pediatric age group, pancreatoblastoma is also closely related...
September 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27267993/surgical-and-molecular-pathology-of-pancreatic-neoplasms
#6
REVIEW
Wenzel M Hackeng, Ralph H Hruban, G Johan A Offerhaus, Lodewijk A A Brosens
BACKGROUND: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. MAIN BODY: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment...
June 7, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27134883/pancreatoblastoma-an-unusual-occurrence-of-a-tumour-in-paediatric-age-group-a-case-report
#7
Pankaj Halder, Bedabrata Mukhopadhyay, Chhanda Das, Madhumita Mukhopadhyay
Pancreatoblastoma, is rare exocrine malignant tumour of childhood. We are reporting a case of three-year-old child presented to our hospital suffering from vague abdominal pain for further examination and treatment. Clinical examination revealed only a palpable abdominal mass. CT Scan revealed a huge complex space occupying lesion 9.1x8.8x9.2cm with large central cystic degeneration and lobulated enhancing peripheral solid components with foci of calcification, seem to arise from body and tail regions of pancreas...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27046982/pancreatoblastoma-masquerading-as-hepatoblastoma-a-diagnostic-dilemma
#8
Aruna Prabhu, Monica Bhagat, Mukta Ramadwar, Sajid S Qureshi
Clinicoradiological and histopathological differentiation of pancreatoblastoma from hepatoblastoma can often be a challenge in clinical practice owing to their peculiar resemblance. We report a case of a 4-year-old boy with a right hypochondriac region mass, which was diagnosed as hepatoblastoma on the basis of imaging, raised tumor marker, and biopsy; however, pancreatic origin of the mass was ascertained on exploration and pancreatoblastoma was confirmed on histopathology.
April 2016: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/27038102/fine-needle-aspiration-cytology-diagnosis-of-a-pancreatoblastoma-in-an-infant-case-report-with-a-summary-of-prior-published-cases
#9
S Das, R Ghosh, A Sen, R N Das, K Saha, U Chatterjee
No abstract text is available yet for this article.
April 1, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/26791924/-report-of-14-cases-with-pancreatoblastoma
#10
Anan Zhang, Jingyan Tang, Shan Wang, Xiaofei Sun, Xiaoli Ma, Ci Pan
OBJECTIVE: To analyze clinical features, outcomes and correlative prognostic factors of the disease. METHOD: Totally 14 newly diagnosed children with pancreatoblastoma at Shanghai Children's Medical Center, Children's Hospital of Chongqing Medical University, Sun Yat-sen University Cancer Center and Beijing Children's Hospital were enrolled into this study between April 2003 and July 2013. The clinical features, surgery, chemotherapy protocol and prognostic factors of patients were retrospectively analyzed...
January 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/26329804/a-need-for-cautious-interpretation-of-elevated-serum-germ-cell-tumor-markers-in-children-review-and-own-experiences
#11
Elzbieta Drozynska, Ewa Bien, Katarzyna Polczynska, Joanna Stefanowicz, Beata Zalewska-Szewczyk, Ewa Izycka-Swieszewska, Anna Ploszynska, Malgorzata Krawczyk, Gabrielle Karpinsky
Protocols for pediatric germ cell tumors (GCT) allow for chemotherapy (CHT) initiation without histological diagnosis, based on typical clinical and radiological picture and increased alphafetoprotein (AFP) or beta-human chorionic gonadotropin serum levels. Such strategy may result in misdiagnoses in rare cases. We present two patients with abdominal tumors and high serum AFP levels, diagnosed as GCT. In both, no tumor shrinkage and increasing AFP was observed after first cycles of multidrug CHT for pediatric GCT...
2015: Biomarkers in Medicine
https://www.readbyqxmd.com/read/26312218/clinicopathological-review-of-pancreatoblastoma-in-adults
#12
REVIEW
Ayodeji Oluwarotimi Omiyale
Pancreatoblastoma (PB) is a rare malignant neoplasm of the pancreas with unknown etiology. It occurs mostly in the pediatric population with very rare documented cases in adults. This is a review of the case reports of the adult pancreatoblastoma in the literature. A total of 35 cases were identified and reviewed with the mean age of 41 years (range, 18-78 years) and the male sex accounted for 51.4% of the cases. Adult Pancreatoblastoma seem to have a predilection for the head of the pancreas which accounted for approximately 49% of the cases reviewed with an average size of 8 cm (range, 1...
August 2015: Gland Surgery
https://www.readbyqxmd.com/read/26174862/pancreatic-tumours-in-children-diagnosis-treatment-and-outcome
#13
Omar Nasher, Nigel J Hall, Neil J Sebire, Paolo de Coppi, Agostino Pierro
PURPOSE: Pancreatic tumours in children are exceedingly rare and as a result constitute a diagnostic and therapeutic challenge to paediatric surgeons. We reviewed our experience with these rare entities. METHODS: Retrospective single institution study on all paediatric pancreatic tumours over a period of 38 years (1973-2011) and literature review. We recorded data relating to the clinical features at presentation, diagnostic evaluation, treatment and outcome. RESULTS: Fourteen patients were identified (eight male)...
September 2015: Pediatric Surgery International
https://www.readbyqxmd.com/read/26137059/adult-pancreatoblastoma-a-case-report-and-review-of-the-literature
#14
Efstratios Zouros, Dimitrios K Manatakis, Spiros G Delis, Christos Agalianos, Charina Triantopoulou, Christos Dervenis
The present study describes the case of a 24-year-old patient who presented with obstructive jaundice and weight loss, and was diagnosed with pancreatoblastoma (PB). Abdominal imaging studies revealed a heterogenous lesion of the pancreatic head with dilatation of the common bile duct. The patient underwent pancreaticoduodenectomy, however, three months after surgery multiple liver and bone metastases were identified on follow-up computed tomography scans. Despite treatment with four cycles of systemic chemotherapy and five courses of radiofrequency ablation, the patient succumbed due to tumour dissemination 13 months after initial diagnosis...
May 2015: Oncology Letters
https://www.readbyqxmd.com/read/26056794/response-of-relapsed-pancreatoblastoma-to-a-combination-of-vinorelbine-and-oral-cyclophosphamide
#15
Chetan Dhamne, Cynthia E Herzog
Pancreatoblastoma is a rare tumor of the pancreas in children, with favorable prognosis if completely resected. If unresectable, neoadjuvant chemotherapy with cisplatin-based regimens are commonly used with good response that allows for resection. For locally aggressive or metastatic disease, neoadjuvant chemotherapy has been reported. Treatment for relapsed or refractory cases is based on anecdotal experiences. We report 2 cases of relapsing pancreatoblastoma with clinical and radiologic response to vinorelbine and cyclophosphamide...
August 2015: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/25857052/-other-pancreatic-neoplasms-pancreatoblastoma-hepatoid-carcinoma-and-medullary-carcinoma
#16
Kenji Notohara
No abstract text is available yet for this article.
March 2015: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/25851961/successful-emergency-combined-therapy-with-partial-splenic-arterial-embolization-and-endoscopic-injection-therapy-against-a-bleeding-duodenal-varix-in-a-child
#17
Hironori Sunakawa, Daisuke Tokuhara, Akira Yamamoto, Satoshi Sugimori, Yoshiki Morotomi, Shino Taniguchi, Masaharu Nakaya, Yuki Cho, Katsutoshi Matsui, Saki Kasuga, Yukari Sakae, Kazumi Yamato, Norifumi Nishida, Sadao Tokimasa, Haruo Shintaku
There is no consensus guidelines for treating duodenal variceal bleeding, which is a rare and life-threatening complication of portal hypertension. Here we report an exceedingly unusual case in a 9-year-old boy who had developed left-sided portal hypertension after surgical treatment for pancreatoblastoma followed by a duodenal variceal bleeding with massive melena, severe anemia (hemoglobin 4.5 g/dL) and hypovolemic shock. Emergency partial splenic arterial embolization (PSE) provided a reduction of variceal bleeding and improved blood pressure...
June 2015: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/25772002/uncommon-presentations-of-common-pancreatic-neoplasms-a-pictorial-essay
#18
REVIEW
Mirko D'Onofrio, Riccardo De Robertis, Paola Capelli, Paolo Tinazzi Martini, Stefano Crosara, Stefano Gobbo, Giovanni Butturini, Roberto Salvia, Emilio Barbi, Roberto Girelli, Claudio Bassi, Paolo Pederzoli
Pancreatic neoplasms are a wide group of solid and cystic lesions with different and often characteristic imaging features, clinical presentations, and management. Among solid tumors, ductal adenocarcinoma is the most common: it arises from exocrine pancreas, comprises about 90% of all pancreatic neoplasms, and generally has a bad prognosis; its therapeutic management must be multidisciplinary, involving surgeons, oncologists, gastroenterologists, radiologists, and radiotherapists. The second most common solid pancreatic neoplasms are neuroendocrine tumors: they can be divided into functioning or non-functioning and present different degrees of malignancy...
August 2015: Abdominal Imaging
https://www.readbyqxmd.com/read/25673604/pancreatoblastoma-in-an-adult
#19
Di Zhang, Na Tang, Yang Liu, En-Hua Wang
Pancreatoblastoma is a malignant pancreatic tumor that rarely occurs in adults. We report a case of an adult female with pancreatoblastoma. A mass was detected in the pancreatic head using computed tomography and ultrasonography. The clinical diagnosis was a solid-pseudopapillary neoplasm of the pancreas. However, after the operation, the final diagnosis was pancreatoblastoma, which showed two lines of differentiation: Acinar differentiation and squamoid corpuscles. The patient is currently in good condition...
January 2015: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/25441307/pathology-and-genetics-of-pancreatic-neoplasms-with-acinar-differentiation
#20
Laura D Wood, David S Klimstra
Pancreatic neoplasms with acinar differentiation, including acinar cell carcinoma, pancreatoblastoma, and carcinomas with mixed differentiation, are distinctive pancreatic neoplasms with a poor prognosis. These neoplasms are clinically, pathologically, and genetically unique when compared to other more common pancreatic neoplasms. Most occur in adults, although pancreatoblastomas usually affect children under 10 years old. All of these neoplasms exhibit characteristic histologic features including a solid or acinar growth pattern, dense neoplastic cellularity, uniform nuclei with prominent nucleoli, and granular eosinophilic cytoplasm...
November 2014: Seminars in Diagnostic Pathology
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