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https://www.readbyqxmd.com/read/29322259/csf-neurofilament-proteins-as-diagnostic-and-prognostic-biomarkers-for-amyotrophic-lateral-sclerosis
#1
Daniela Rossi, Paolo Volanti, Liliana Brambilla, Tiziana Colletti, Rossella Spataro, Vincenzo La Bella
Elevated cerebrospinal fluid (CSF), Neurofilament Light (NF-L) and phosphorylated Heavy (pNF-H) chain levels have been found in Amyotrophic Lateral Sclerosis (ALS), with studies reporting a correlation of both neurofilaments (NFs) with the disease progression. Here, we measured NF-L and pNF-H concentrations in the CSF of ALS patients from a single tertiary Center and investigated their relationship with disease-related variables. A total of 190 ALS patients (Bulbar, 29.9%; Spinal, 70.1%; M/F = 1.53) and 130 controls with mixed neurological diseases were recruited...
January 10, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29309776/glycome-patterns-of-perfusate-in-livers-before-transplantation-associate-with-primary-non-function
#2
Xavier Verhelst, Anja Geerts, Ina Jochmans, Dieter Vanderschaeghe, Agnes Paradissis, Aude Vanlander, Frederik Berrevoet, Géraldine Dahlqvuist, Frederik Nevens, Jacques Pirenne, Xavier Rogiers, Nico Callewaert, Roberto I Troisi, Hans Van Vlierberghe
BACKGROUND & AIMS: Primary non-function (PNF) is a rare complication after liver transplantation that requires urgent re-transplantation. PNF is associated with livers from extended-criteria donors. Clinical and biochemical factors have not been identified that reliably associate with graft function after liver transplantation. Serum patterns of N-glycans associate with changes in the liver. We analyzed perfusate from grafted liver to identify protein glycosylation patterns associated with PNF...
January 5, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29305454/efficacy-and-adverse-effects-of-collagenase-use-in-the-treatment-of-dupuytren-s-disease-a-meta-analysis
#3
R Sanjuan-Cerveró, F J Carrera-Hueso, P Vazquez-Ferreiro, M A Ramon-Barrios
AIMS: The aim of this meta-analysis was to assess the safety and efficacy of collagenase clostridium histolyticum compared with fasciectomy and percutaneous needle fasciotomy (PNF) for Dupuytren's disease. MATERIALS AND METHODS: We systematically searched PubMed, EMBASE, LILACS, Web of Science, Cochrane, Teseo and the ClinicalTrials.gov registry for clinical trials and cohort or case-control studies which compared the clinical outcomes and adverse effects of collagenase with those of fasciectomy or PNF...
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29291173/phosphorylated-neurofilament-heavy-a-potential-blood-biomarker-to-evaluate-the-severity-of-acute-spinal-cord-injuries-in-adults
#4
Ajai Singh, Vineet Kumar, Sabir Ali, Abbas Ali Mahdi, Rajeshwer Nath Srivastava
Aims: The aim of this study is to analyze the serial estimation of phosphorylated neurofilament heavy (pNF-H) in blood plasma that would act as a potential biomarker for early prediction of the neurological severity of acute spinal cord injuries (SCI) in adults. Settings and Design: Pilot study/observational study. Subjects and Methods: A total of 40 patients (28 cases and 12 controls) of spine injury were included in this study. In the enrolled cases, plasma level of pNF-H was evaluated in blood samples and neurological evaluation was performed by the American Spinal Injury Association Injury Scale at specified period...
October 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29288991/nerve-ultrasound-in-neurofibromatosis-type-1-a-follow-up-study
#5
Johan A Telleman, Menno D Stellingwerff, Geert J Brekelmans, Leo H Visser
OBJECTIVE: To investigate development of sonographic abnormalities and applications of high-resolution ultrasonography (HRUS) in neurofibromatosis type 1 (NF1). METHODS: Sixteen asymptomatic or minimally symptomatic NF1 patients underwent HRUS at inclusion and 1 year follow-up. Upper and lower extremity nerves were investigated. Peripheral nerve involvement was graded. RESULTS: Plexiform neurofibromas (PNFs) were found in 7 patients (43...
November 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29234287/synergistic-effects-of-proprioceptive-neuromuscular-facilitation-and-manual-lymphatic-drainage-in-patients-with-mastectomy-related-lymphedema
#6
Kyung-Jin Ha, Sang-Yeol Lee, Hojun Lee, Seung-Jun Choi
Purpose: Manual lymphatic drainage (MLD) and proprioceptive neuromuscular facilitation (PNF) are potential therapeutic strategies to reduce mastectomy-induced edema. The purpose of this study was to investigate whether the combination of these therapies would induce synergistic effects to treat lymphedema-related complications and to analyze a possible physiological mechanism involved in the observed effects. Methods: A total of 55 patients diagnosed with mastectomy-induced lymphedema were recruited and randomized into three experimental groups: PNF group (n = 17), MLD group (n = 20), and PNF + MLD group (n = 18)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29233831/the-efficacy-of-the-proprioceptive-neuromuscular-facilitation-pnf-approach-in-stroke-rehabilitation-to-improve-basic-activities-of-daily-living-and-quality-of-life-a-systematic-review-and-meta-analysis-protocol
#7
Francesc Xavier Guiu-Tula, Rosa Cabanas-Valdés, Mercè Sitjà-Rabert, Gerard Urrútia, Natàlia Gómara-Toldrà
INTRODUCTION: Proprioceptive neuromuscular facilitation (PNF) is a widely used rehabilitation concept, although its efficacy has not yet been demonstrated in stroke survivors. The aim of this systematic review is to identify, assess and synthesise the potential benefits of using PNF to improve the activities of daily living (ADL) and quality of life (QoL) of individuals with stroke. METHODS AND ANALYSIS: A systematic electronic search will be conducted in MEDLINE, Embase, CENTRAL and PEDro...
December 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29214122/peripheral-nerve-sheath-tumors-of-the-upper-extremity-and-hand-in-patients-with-neurofibromatosis-type-1-topography-of-tumors-and-evaluation-of-surgical-treatment-in-62-patients
#8
Reinhard E Friedrich, Caroline Diekmeier
Objective: Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome with a tendency to develop peripheral nerve sheath tumors (PNST). Plexiform neurofibromas (PNF) are detected in a high proportion of affected patients. The tumors can lead to severe disfigurement and are classified as precancerous. This study examines the surgical procedures that have been performed on large PNST of the upper limb and hand, and investigates whether a specific distribution pattern of the tumors can be detected in surgically treated cases...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/29200651/effects-of-taping-and-proprioceptive-neuromuscular-facilitation-for-stance-phase-duration-of-stroke-patients
#9
Youn-Bum Sung, Jun-Cheol Lee, Kyoung Kim
[Purpose] The purpose of this study was to investigate the effects of taping and proprioceptive neuromuscular facilitation in stroke patients. [Subjects and Methods] Thirty patients who were diagnosed with hemiparalysis due to stroke were selected as subjects of study. Experiment group 1 patients had Kinesio taping applied before applying the PNF, while experiment group 2 patients had McConell taping applied before applying the PNF. The control group had only the PNF applied. The dartfish program was used to evaluate the stance phase of stroke patients...
November 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29200648/the-immediate-effects-of-proprioceptive-neuromuscular-facilitation-with-taping-on-gait-parameters-in-patients-with-chronic-stroke
#10
Shin-Jun Park
[Purpose] The purpose of the present study was to examine the immediate effects of simultaneous application of proprioceptive neuromuscular facilitation (PNF) and elastic taping (T), and the removal of the elastic tape, on the gait parameters of stroke patients. [Subjects and Methods] Twenty stroke patients were divided into a proprioceptive neuromuscular facilitation group (PNFG, n=7), a taping group (TG, n=6), and a proprioceptive neuromuscular facilitation with taping group (PNFTG, n=7). Relevant interventions were applied for 30 minutes, the tape was removed, and gait parameters were evaluated...
November 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29193197/signaling-profiles-of-blood-leukocytes-in-sepsis-and-in-acute-pancreatitis-in-relation-to-disease-severity
#11
Krista Kuuliala, Anne K Penttilä, Kirsi-Maija Kaukonen, Harri Mustonen, Antti Kuuliala, Jani Oiva, Mari Hämäläinen, Eeva Moilanen, Ville Pettilä, Pauli Puolakkainen, Leena Kylänpää, Heikki Repo
Intracellular signaling in blood leukocytes shows multiple aberrations in acute pancreatitis (AP) complicated by organ dysfunction (OD). We studied whether the aberrations associate with severity of AP and occur in sepsis complicated by OD. Study comprises 14 sepsis patients (11 with shock), 18 AP patients (9 mild; 6 moderately severe; 3 severe), and 28 healthy volunteers. Within 48 hours after admission to hospital, phosphorylation of nuclear factor-ĸB (NF-ĸB), signal transducers and activators of transcription (STATs) 1,3, and extracellular signal-regulated kinases 1/2 was measured from stimulated or non-stimulated leukocytes using phosphospecific whole blood flow cytometry...
November 29, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29185982/adrenergic-regulation-during-acute-hepatic-infection-with-entamoeba-histolytica-in-the-hamster-involvement-of-oxidative-stress-nrf2-and-nf-kappab
#12
Liseth Rubi Aldaba-Muruato, Martín Humberto Muñoz-Ortega, José Roberto Macías-Pérez, Julieta Pulido-Ortega, Sandra Luz Martínez-Hernández, Javier Ventura-Juárez
Oxidative stress and transcriptional pathways of nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa-B (NF-κB) are critically involved in the etiopathology of amebic liver abscess (ALA). In this work, we studied the relationship between the adrenergic nervous system and ALA in the hamster. ALA was visible at 12 h of infection. While 6-hydroxidopamine (6-OHDA) decreased infection, propranolol (β-adrenergic blocker) treatment was associated with less extensive liver damage, and phentolamine treatment (α-adrenergic blocker) significantly reduced ALA compared to 6-OHDA and propranolol...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29182391/effect-of-meloxicam-administration-on-movement-feeding-and-drinking-behaviors-of-transported-and-nontransported-cattle
#13
Sarah F Capik, Brad J White, Robert L Larson, Nicholas Van Engen, Johann F Coetzee
OBJECTIVE To evaluate the effects of meloxicam on movement, feeding, and drinking behaviors of transported and nontransported cattle. ANIMALS 100 crossbred beef steers. PROCEDURES During experiment 1 of a 2-experiment study, calves from a livestock auction received meloxicam (1 mg/kg, PO; n = 50) or a lactose placebo (1 capsule/calf; 50; control), then calves were transported approximately 1,000 km overnight to a feedlot, where they were instrumented with a real-time location-monitoring ear tag, placed in randomly assigned pens (n = 5 pens/treatment), and monitored for 21 days...
December 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29178539/non-melanoma-hutchinson-s-sign-a-reappraisal-of-this-important-remarkable-melanoma-simulant
#14
L Robert Baran, Beth S Ruben, Paul Kechijian, Luc Thomas
BACKGROUND: More than 20 years ago our reappraisal of the Hutchinson Sign (HS) gave birth to the concept of the Pseudo-Hutchinson sign. OBJECTIVES: We have found it interesting to emphasize some important histologic points and to expand the list of the numerous HS simulants. METHODS: We have examined the cutaneous samples taken from the pigmented skin of patients in association with nail matrix biopsy. We have also extended the long list of non-melanoma HS...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29155020/the-uk-dcd-risk-score-a-new-proposal-to-define-futility-in-donation-after-circulatory-death-liver-transplantation
#15
Andrea Schlegel, Marit Kalisvaart, Irene Scalera, Richard W Laing, Hynek Mergental, Darius F Mirza, Thamara Perera, John Isaac, Philipp Dutkowski, Paolo Muiesan
OBJECTIVES: To design a new score on risk assessment in liver transplantation donated after circulatory death (DCD) based on donor and recipient parameters. BACKGROUND: Primary-non-function (PNF) and ischemic cholangiopathy (IC) are the most feared complications following DCD liver transplantation. METHODS: Using the United Kingdom (UK) national DCD database, a risk analysis was performed in adult recipients of DCD liver grafts in UK between 2000 and 2015 (n=1153)...
November 15, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29114517/effects-of-proprioceptive-neuromuscular-facilitation-based-abdominal-muscle-strengthening-training-on-pulmonary-function-pain-and-functional-disability-index-in-chronic-low-back-pain-patients
#16
Beom-Ryong Kim, Hye-Jin Lee
The purpose of this study was to evaluate the effect of abdominal muscle strengthening training (AMST) using proprioceptive neuromuscular facilitation (PNF) on pulmonary function, pain, and functional disability index in chronic low back pain (CLBP) patients. Thirty CLBP patients were randomly assigned to the traditional physical therapy (control) group (n=15) and PNF-AMST group (n=15). Forced expiratory volume at 1 second (FEV1) was measured to measure changes in pulmonary function. To measure the degree of pain, a visual analog scale (VAS) was used...
August 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29114507/investigation-of-alpha-band-of-the-electroencephalogram-before-and-after-a-task-of-proprioceptive-neuromuscular-facilitation
#17
Luan Correia Costa, Alzira Andrade, Lysnara Lial, Rayele Moreira, Ane Caroline Lima, Astrogildo Magvinier, Ricardo Lira, Anderson Aragão, Pedro Henrique Ulisses, Eric Crespo, Marco Orsini, Silmar Teixeira, Victor Hugo Bastos
The proprioceptive neuromuscular facilitation (PNF) sets up a feature of treatment developed with the objective to facilitate and improve the motor performance. The aim of this study was to investigate in healthy female individuals the effects of electrophysiological of a diagonal of the PNF upper limb. The sample consisted of 30 female participants aged between 18 to 28 years, randomly divided into 3 groups (G1, G2, and G3). The three groups had 2 moments of electroencephalographic signal detection, before and after the task...
August 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29098059/curcumin-reverses-the-diazepam-induced-cognitive-impairment-by-modulation-of-oxidative-stress-and-erk-1-2-nf-%C3%AE%C2%BAb-pathway-in-brain
#18
Alexandra C Sevastre-Berghian, Vlad Făgărăsan, Vlad A Toma, Ioana Bâldea, Diana Olteanu, Remus Moldovan, Nicoleta Decea, Gabriela A Filip, Simona V Clichici
Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was to evaluate the effects of curcumin (CUR) on spatial cognition, ambulatory activity, and blood and brain oxidative stress levels. The ERK/NF-κB signaling pathway and the histopathological changes in the hippocampus and frontal lobe, in diazepam-treated rats, were also analyzed. The animals were divided into 4 groups: control, carboxymethylcellulose (CMC) + CUR, CMC + DZP, and CUR + CMC + DZP...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29096587/proprioceptive-neuromuscular-facilitation-increases-alpha-absolute-power-in-the-dorsolateral-prefrontal-cortex-and-superior-parietal-cortex
#19
Lysnara Lial, Rayele Moreira, Luan Correia, Alzira Andrade, Ane Caroline Pereira, Ricardo Lira, Rogério Figueiredo, Fernando Silva-Júnior, Marco Orsini, Pedro Ribeiro, Bruna Velasques, Maurício Cagy, Silmar Teixeira, Victor Hugo Bastos
The physiotherapist's clinical practice includes proprioceptive neuromuscular facilitation (PNF), which is a treatment concept that accelerates the response of neuromuscular mechanisms through spiral and diagonal movements. The adaptations that occur in the nervous system following PNF are still poorly described in the literature. Thus, this study had a goal to investigate the electrophysiological changes in the fronto-parietal circuit during PNF and movement in sagittal and diagonal patterns. This study included 30 female participants, who were divided into three groups (control, PNF, and flexion groups)...
September 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29084092/acute-effects-of-active-ballistic-passive-and-proprioceptive-neuromuscular-facilitation-streching-on-sprint-and-vertical-jump-performance-in-trained-young-soccer-players
#20
Lucas de Paula Oliveira, Luiz Henrique Palucci Vieira, Rodrigo Aquino, João Paulo Vieira Manechini, Paulo Roberto Pereira Santiago, Enrico Fuini Puggina
The aim of the present study was to compare the acute effects of active (AC), ballistic (BA), passive (PA), proprioceptive neuromuscular facilitation stretching (PNF) methods on performance in vertical jumping, sit and reach, and sprinting in young soccer players. Twelve trained soccer players (17.67 ± 0.87 years) participated in the study. The jump height (H), peak power (PP), and relative power (RP) in the squat jump (SJ) and countermovement jump (CMJ), the range of motion (ROM), the rate of perceived exertion (RPE), and time (s) in 10-20-30 m sprints were evaluated...
October 27, 2017: Journal of Strength and Conditioning Research
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