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https://www.readbyqxmd.com/read/28937253/sirt1-mediates-improvement-in-cognitive-defects-induced-by-focal-cerebral-ischemia-following-hyperbaric-oxygen-preconditioning-in-rats
#1
P Ding, D Ren, S He, M He, G Zhang, Y Chen, H Sang, Z Peng, W Yan
Hyperbaric oxygen preconditioning (HBO-PC) has been proposed as a safe and practical approach for neuroprotection in ischemic stroke. However, it is not known whether HPO-PC can improve cognitive deficits induced by cerebral ischemia, and the mechanistic basis for any beneficial effects remains unclear. We addressed this in the present study using rats subjected to middle cerebral artery occlusion (MCAO) as an ischemic stroke model following HBO-PC. Cognitive function and expression of phosphorylated neurofilament heavy polypeptide (pNF-H) and doublecortin (DCX) in the hippocampus were evaluated 14 days after reperfusion and after short interfering RNA-mediated knockdown of sirtuin1 (Sirt1)...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28917432/complications-after-treating-dupuytren-s-disease-a-systematic-literature-review
#2
C Krefter, M Marks, S Hensler, D B Herren, M Calcagni
The objective of this study was to review the incidence of complications associated with different treatment options for patients with Dupuytren's disease. In a systematic literature review, the PubMed, EMBASE, Cochrane and Scopus databases were searched for clinical studies reporting complications after collagenase treatment, percutaneous needle fasciotomy (PNF), fasciectomy and dermofasciectomy. The incidence of complications was extracted from each study and stratified by procedure. From a total of 2251 references, 113 studies were analyzed and included with complication incidences varying from 0% to 100%...
September 13, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28910180/nrf2-mediated-ho-1-induction-and-antineuroinflammatory-activities-of-halleridone
#3
Ji Yeon Seo, Euisun Pyo, Junsoo Park, Jong-Sang Kim, Sang Hyun Sung, Won Keun Oh
Nuclear factor E2-related factor 2 (Nrf2) is the master regulator of antioxidant enzymes and is known to act on the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) signaling pathway. Few studies have examined the bioactivity of halleridone. Herein, we investigated whether halleridone, which was isolated from the stems of the plant Cornus walteri, could regulate Nrf2-mediated heme oxygenase (HO)-1 expression and prevent intramicroglial inflammation induced by amyloid beta (Aβ)1-42 overexpression...
September 14, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28905003/an-immediate-effect-of-pnf-specific-mobilization-on-the-angle-of-trunk-rotation-and-the-trunk-pelvis-hip-angle-range-of-motion-in-adolescent-girls-with-double-idiopathic-scoliosis-a-pilot-study
#4
A Stępień, K Fabian, K Graff, M Podgurniak, A Wit
BACKGROUND: Impairment of spine rotation is a key concept in several theories explaining the pathogenesis and progression of scoliosis. In previous studies, a more limited range of motion in scoliotic girls compared to their non-scoliotic peers was noted. The Trunk-Pelvis-Hip Angle measurement is a test used to assess the range of motion in the trunk-pelvis-hip complex in the transverse plane. The aim of this study was to assess an immediate effect of Proprioceptive Neuromuscular Facilitation specific mobilization (mPNF) on the angle of trunk rotation and Trunk-Pelvis-Hip Angle range of motion in adolescent girls with double scoliosis...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28869555/poly-neopentyl-glycol-furanoate-a-member-of-the-furan-based-polyester-family-with-smart-barrier-performances-for-sustainable-food-packaging-applications
#5
Laura Genovese, Nadia Lotti, Valentina Siracusa, Andrea Munari
In the last decade, there has been an increased interest from the food packaging industry toward the development and application of bioplastics, to contribute to the sustainable economy and to reduce the huge environmental problem afflicting the planet. In the present work, we focus on a new furan-based polyester, poly(neopentyl glycol 2,5-furanoate) (PNF) to be used for sustainable food packaging applications. The aromatic polyester was successfully synthesized with high molecular weight, through a solvent-free process, starting directly from 2,5-furandicarboxylic acid...
September 4, 2017: Materials
https://www.readbyqxmd.com/read/28864290/bone-marrow-derived-mesenchymal-stem-cells-regress-aortic-aneurysm-via-the-nf-kb-smad3-and-akt-signaling-pathways
#6
Aika Yamawaki-Ogata, Hideki Oshima, Akihiko Usui, Yuji Narita
BACKGROUND AIMS: We have confirmed that aortic aneurysm (AA) can be regressed by the administration of bone marrow-derived mesenchymal stem cells (BM-MSCs). We investigated the kinetics of signaling pathways in AA following treatment with BM-MSCs. METHODS: Angiotensin II-infused apolipoprotein E-deficient mice were treated by intravenous injection of 1 × 10(6) BM-MSCs in 0.2 mL saline (BM-MSCs group, n = 5) or 0.2 mL saline (saline group, n = 5)...
August 30, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28827109/chromofungin-chr-chga47-66-is-downregulated-in-persons-with-active-ulcerative-colitis-and-suppresses-pro-inflammatory-macrophage-function-through-the-inhibition-of-nf-%C3%AE%C2%BAb-signaling
#7
Nour Eissa, Hayam Hussein, Laëtitia Kermarrec, Omar Elgazzar, Marie-Helene Metz-Boutigue, Charles N Bernstein, Jean-Eric Ghia
Chromogranin-A (CHGA) is a prohormone secreted by neuroendocrine cells and is a precursor of several bioactive peptides, which are implicated in different and distinctive biological and immune functions. Chromofungin (CHR: CHGA47-66) is a short peptide with antimicrobial effects and encodes from CHGA exon-IV. Inflammatory bowel disease (IBD) is characterized by alterations in the activation of pro-inflammatory pathways, pro-inflammatory macrophages (M1), and nuclear transcription factor kappa B (NF-κB) signaling leading to the perpetuation of the inflammatory process...
August 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28812113/-pathophysiology-of-intracranial-injuries
#8
REVIEW
D Lahner, G Fritsch
Traumatic brain injury (TBI) constitutes a heterogeneous condition that affects the most complex organ of the human body. It is commonly classified by its location as focal injury (e.g. epidural hematoma) and diffuse injury (e.g. diffuse axonal shearing injury) as well as by primary and secondary tissue injury. Accordingly, direct mechanical force causes the primary insult. The tissue damage occurring afterwards is subsumed under the term secondary brain damage. Some of these processes are overlapping and include in the early phase local cerebral ischemia resulting in excitotoxicity, which together with the triggered neuroinflammatory cascade causes the formation of cerebral edema and ultimately increased intracranial pressure once the intracranial compliance is exhausted...
August 15, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28806837/-zum-beitrag-die-technik-der-erweiterten-perkutanen-nadelfasziotomie-pnf-bei-der-dupuytren-schen-kontraktur
#9
Albrecht Meinel
No abstract text is available yet for this article.
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28801950/can-chronic-stretching-change-the-muscle-tendon-mechanical-properties-a-review
#10
REVIEW
Sandro R Freitas, Bruno Mendes, Guillaume Le Sant, Ricardo J Andrade, Antoine Nordez, Zoran Milanovic
PURPOSE: It is recognized that stretching is an effective method to chronically increase the joint range of motion. However, the effects of stretching training on the muscle-tendon structural properties remain unclear. This systematic review with meta-analysis aimed to determine whether chronic stretching alter the muscle-tendon structural properties. METHODS: Published papers regarding longitudinal stretching (static, dynamic and/or PNF) intervention (either randomized or not) in humans of any age and health status, with more than 2 weeks in duration and at least 2 sessions per week, were searched in PubMed, PEDro, ScienceDirect and ResearchGate databases...
August 12, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28796278/prophylactic-stretching-does-not-reduce-cramp-susceptibility
#11
Kevin C Miller, James D Harsen, Blaine C Long
INTRODUCTION: Some clinicians advocate stretching to prevent muscle cramps. It is unknown whether static or proprioceptive neuromuscular facilitation (PNF) stretching increases cramp threshold frequency (TFc ), a quantitative measure of cramp susceptibility. METHODS: Fifteen individuals completed this randomized, counterbalanced, cross-over study. We measured passive hallux range of motion (ROM) and then performed 3 minutes of either static stretching, PNF stretching (hold-relax-with agonist contraction), or no stretching...
August 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28792729/ni3s2-nanosheet-flowers-decorated-with-cds-quantum-dots-as-a-highly-active-electrocatalysis-electrode-for-synergistic-water-splitting
#12
Shanqing Qu, Jun Huang, Jinsong Yu, Guangliang Chen, Wei Hu, Mengmeng Yin, Rui Zhang, Sijun Chu, Chaorong Li
A facile and effective strategy for fabricating a three-dimensionally (3D) structured nanocomposite catalyst based on nonprecious metals for water splitting in alkaline electrolyzers is reported in this paper. This nanocomposite catalyst consists of the CdS quantum dots (QDs) decorated Ni3S2 nanosheet flowers deposited on the plasma-treated nickel foam (PNF). The NiO formed during the plasma treatment is shown to play an important role for pushing the hydrogen and oxygen evolution reactions (HER and OER) in alkaline media...
August 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28772351/the-influence-of-functional-warm-ischemia-time-on-dcd-liver-transplant-recipients-outcomes
#13
Jessica C Coffey, Kerollos N Wanis, Diethard Monbaliu, Nicholas Gilbo, Markus Selzner, Neeta Vachharajani, Mark A Levstik, Max Marquez, Mb Majella Doyle, Jacques Pirenne, David Grant, Julie K Heimbach, William Chapman, Kelly Vogt, Roberto Hernandez-Alejandro
BACKGROUND: Duration of functional warm ischemia (f-WIT) is thought to have a causal effect on outcomes in controlled donation after circulatory death (DCD) liver transplantation (LT). METHODS: A retrospective cohort study was conducted at five centers. Data were extracted on donor and recipient characteristics, with attention to parameters recorded during withdrawal of life support to in-situ cold perfusion. F-WIT was the time elapsed from any of the hemodynamic and oxygenation parameters to the start of in-situ cold perfusion...
August 3, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28750960/the-effects-of-opposite-directional-static-contraction-of-the-muscles-of-the-right-upper-extremity-on-the-ipsilateral-right-soleus-h-reflex
#14
Tomoko Shiratani, Mitsuo Arai, Hironobu Kuruma, Kazue Masumoto
The objective of this study was to explore the neurophysiological remote after-effects of resistive static contraction (SC) of the muscles of the upper extremity, considering the resistant direction on the ipsilateral (right) soleus H-reflex. The participants included 12 normal subjects with a mean (SD) age of 23.8 (2.8) years. The subjects were asked to maintain their upper extremity against the traction force, at a level of resistance that was 50% of the maximal SC strength. A 20-s SC of the muscles of the upper extremity utilizing contraction of the upper extremity muscles using a diagonal flexion (shoulder flexion-adduction-external rotation) or extension (shoulder extension-abduction-internal rotation), a proprioceptive neuromuscular facilitation (PNF) pattern was induced...
July 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28750210/phosphorylated-neurofilament-h-pnf-h-as-a-potential-diagnostic-marker-for-neurological-disorders-in-horses
#15
A R Intan-Shameha, Thomas J Divers, Jennifer K Morrow, Amy Graves, Emil Olsen, Amy L Johnson, Hussni O Mohammed
The current study aimed at the investigating the potential use of phosphorylated neurofilament H (pNF-H) as a diagnostic biomarker for neurologic disorders in the horse. Paired serum and cerebrospinal fluid (CSF) samples (n=88) and serum only (n=30) were obtained from horses diagnosed with neurologic disorders and clinically healthy horses as control. The neurologic horses consisted of equine protozoal myeloencephalitis (EPM) (38 cases) and cervical vertebral malformation (CVM) (23 cases). Levels of pNF-H were determined using an ELISA...
July 18, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28734125/a-systematic-review-and-meta-analysis-of-cold-in-situ-perfusion-and-preservation-of-the-hepatic-allograft-working-towards-a-unified-approach
#16
REVIEW
Ahmer M Hameed, Jerome M Laurence, Vincent W T Lam, Henry C Pleass, Wayne J Hawthorne
BACKGROUND: The efficacy of cold in situ perfusion and static storage of the liver is one possible determinant of transplantation outcomes. The aim of this study was to determine whether there is evidence to substantiate a preference for a particular perfusion route (aortic or dual) or perfusion/preservation solution in donation after brain-death (DBD) liver transplantation. METHODS: The Embase, Medline and Cochrane databases were utilized (1980-2017). Random effects modeling was used to estimate effects on transplantation outcomes based upon (i) aortic or dual in situ perfusion, and (ii) the use of University of Wisconsin (UW), histidine-tryptophan-ketoglutarate (HTK), Celsior and/or Institut Georges Lopez-1 (IGL-1) for perfusion/preservation...
July 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28727082/comparison-of-amino-acid-digestibility-in-full-fat-soybean-two-soybean-meals-and-peanut-flour-between-broiler-chickens-and-growing-pigs
#17
C S Park, A Helmbrecht, J K Htoo, O Adeola
The aim of this study was to determine the apparent ileal digestibility (AID) and the standardized ileal digestibility (SID) of CP and AA in full-fat soybean (FFSB), solvent-extracted soybean meal containing 430 g/kg CP (SBM-43), solvent-extracted soybean meal containing 470 g/kg CP (SBM-47), and peanut flour (PNF) fed to broiler chickens and pigs and to compare the digestibility of CP and AA between broiler chickens and pigs. Four diets were prepared to contain FFSB, SBM-43, SBM-47, and PNF as the sole source of N...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28697541/first-experience-of-cadaveric-renal-transplantation-in-sri-lanka
#18
P K Harrischandra, D N Jayatunge, U B Rambukwella, I B Sumithraarachchi, U I Karunadasa, A S Abeyagunawardena
Objectives: To analyse the outcome of 50 consecutive cadaveric renal transplants performed in Sri Lanka. Methods: This was a single-centre longitudinal cohort study conducted in the Nephrology and Kidney Transplant Unit, Teaching Hospital Kandy, Sri Lanka. Records of 50 Sri Lankan cadaveric renal transplant recipients from 7th December 2004 to 1st September 2013 were reviewed and categorized according to early graft function, cold ischaemia time and the duration of dialysis before surgery...
June 30, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28687308/deep-hypothermia-therapy-attenuates-lps-induced-microglia-neuroinflammation-via-the-stat3-pathway
#19
G Tong, A Krauss, J Mochner, S Wollersheim, P Soltani, F Berger, K R L Schmitt
Deep hypothermia therapy (HT) is a standard method for neuroprotection during complex pediatric cardiac surgery involving extracorporeal circulation and deep hypothermic cardiac arrest. The procedure, however, can provoke systemic inflammatory response syndrome (SIRS), one of the most severe side effects associated with pediatric cardiac surgery. To date, the cellular inflammatory mechanisms induced by deep HT remain to be elucidated. Therefore, we investigated the effects of deep HT (17°C) and rewarming on the inflammatory response in lipopolysaccharide (LPS) stimulated BV-2 murine microglia...
September 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/28672919/brain-injury-with-systemic-inflammation-in-newborns-with-congenital-heart-disease-undergoing-heart-surgery
#20
Rossitza P Pironkova, Joseph Giamelli, Howard Seiden, Vincent A Parnell, Dorota Gruber, Cristina P Sison, Czeslawa Kowal, Kaie Ojamaa
The potential role of systemic inflammation on brain injury in newborns with congenital heart disease (CHD) was assessed by measuring levels of central nervous system (CNS)-derived proteins in serum prior to and following cardiac surgery. A total of 23 newborns (gestational age, 39±1 weeks) with a diagnosis of CHD that required cardiac surgery with cardiopulmonary bypass (CPB) were enrolled in the current study. Serum samples were collected immediately prior to surgery and 2, 24 and 48 h following CPB, and serum levels of phosphorylated neurofilament-heavy subunit (pNF-H), neuron-specific enolase (NSE) and S100B were analyzed...
July 2017: Experimental and Therapeutic Medicine
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