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https://www.readbyqxmd.com/read/27929120/neurofilaments-in-blood-and-csf-for-diagnosis-and-prediction-of-onset-in-creutzfeldt-jakob-disease
#1
Petra Steinacker, Kaj Blennow, Steffen Halbgebauer, Song Shi, Viktoria Ruf, Patrick Oeckl, Armin Giese, Jens Kuhle, Dana Slivarichova, Henrik Zetterberg, Markus Otto
While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included in the diagnostic criteria, no blood biomarkers are available. Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comparison to CSF markers (NF-L and phosphorylated NF heavy chain (pNF-H), tau, S100B, 14-3-3) and prion conversion assay (real-time quaking induced conversion (RT-QuIC)) for sporadic and genetic CJD. Importantly, a Gerstmann-Sträussler-Scheinker mutation carrier in the asymptomatic phase and at disease onset was included as well...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27906828/presence-of-cytotoxic-extracellular-histones-in-machine-perfusate-of-donation-after-circulatory-death-kidneys
#2
Tim C van Smaalen, Daniëlle M H Beurskens, E R Pieter Hoogland, Bjorn Winkens, Maarten H L Christiaans, Chris P Reutelingsperger, L W Ernest van Heurn, Gerry A F Nicolaes
BACKGROUND: Extracellular histones are cytotoxic molecules that are related to cell stress and death. They have been shown to play a crucial role in multiple pathophysiologic processes like sepsis, inflammation, vascular dysfunction and thrombosis. Their role in organ donation and graft function and survival is still unknown. The aim of this study was to assess whether an association exists between the presence of extracellular histones in machine perfusates and deceased donor kidney viability...
December 1, 2016: Transplantation
https://www.readbyqxmd.com/read/27895574/robot-assisted-rehabilitation-of-ankle-plantar-flexors-spasticity-a-3-month-study-with-proprioceptive-neuromuscular-facilitation
#3
Zhihao Zhou, Yao Sun, Ninghua Wang, Fan Gao, Kunlin Wei, Qining Wang
In this paper, we aim to investigate the effect of proprioceptive neuromuscular facilitation (PNF)-based rehabilitation for ankle plantar flexors spasticity by using a Robotic Ankle-foot Rehabilitation System (RARS). A modified robot-assisted system was proposed, and seven poststroke patients with hemiplegic spastic ankles participated in a 3-month robotic PNF training. Their impaired sides were used as the experimental group, while their unimpaired sides as the control group. A robotic intervention for the experimental group started from a 2-min passive stretching to warming-up or relaxing the soleus and gastrocnemius muscles and also ended with the same one...
2016: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/27876112/antioxidant-defense-of-nrf2-vs-pro-inflammatory-system-of-nf-%C3%AE%C2%BAb-during-the-amoebic-liver-infection-in-hamster
#4
Liseth R Aldaba-Muruato, Martin H Muñoz-Ortega, María Del R Campos-Esparza, José R Macías-Pérez, Nayeli A Márquez-Muñoz, Ana G Villalobos-Santos, Javier Ventura-Juárez
Entamoeba histolytica is the causative agent of amoebic liver abscess (ALA), which course with an uncontrolled inflammation and nitro-oxidative stresses, although it is well known that amoeba has an effective defence mechanisms against this toxic environment, the underlying molecular factors responsible for progression of tissue damage remain largely unknown. The purpose of the present study was to determine during the acute stage of ALA in hamsters, the involvement of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-kappa B (NF-κB), which are activated in response to oxidative stress...
November 23, 2016: Parasitology
https://www.readbyqxmd.com/read/27857681/early-cytoskeletal-protein-modifications-precede-overt-structural-degeneration-in-the-dba-2j-mouse-model-of-glaucoma
#5
Gina N Wilson, Matthew A Smith, Denise M Inman, Christine M Dengler-Crish, Samuel D Crish
Axonal transport deficits precede structural loss in glaucoma and other neurodegenerations. Impairments in structural support, including modified cytoskeletal proteins, and microtubule-destabilizing elements, could be initiating factors in glaucoma pathogenesis. We investigated the time course of changes in protein levels and post-translational modifications in the DBA/2J mouse model of glaucoma. Using anterograde tract tracing of the retinal projection, we assessed major cytoskeletal and transported elements as a function of transport integrity in different stages of pathological progression...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27819429/online-personalized-normative-alcohol-feedback-for-parents-of-first-year-college-students
#6
Lucy E Napper, Joseph W LaBrie, Andrew M Earle
This study examined the efficacy of a personalized normative feedback (PNF) alcohol intervention for parents of students transitioning into college. A sample of 399 parent-student dyads were recruited to take part in the intervention during the summer prior to matriculation. Parents were randomly assigned to receive either normative feedback regarding student drinking and other college parents' alcohol-related communication or general college health norm information. Students completed measures of alcohol use, alcohol consequences, and parent-child alcohol-specific communication both 1 and 6 months after matriculation...
November 7, 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27819323/donor-and-recipient-genetic-variants-in-nlrp3-associate-with-early-acute-rejection-following-kidney-transplantation
#7
Mark C Dessing, Jesper Kers, Jeffrey Damman, Gerjan J Navis, Sandrine Florquin, Jaklien C Leemans
NLRP3 (NOD-like receptor family, pyrin domain containing 3) is a member of the inflammasome family and is of special interest in renal disease. Experimental studies have shown that Nlrp3 plays a significant role in the induction of renal damage and dysfunction in acute and chronic renal injury. However, the role of NLRP3 in human renal disease is completely unknown. From a retrospective cohort study, we determined in 1271 matching donor and recipient samples if several NLRP3 single nucelotide polymorphisms (SNPs) were associated with primary non-function (PNF), delayed graft function (DGF), biopsy-proven acute rejection (BPAR) and death-censored graft and patient survival...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818278/effect-of-amitriptyline-treatment-on-neurofilament-h-protein-in-an-experimental-model-of-depression
#8
Maria Domenica Sanna, Carla Ghelardini, Nicoletta Galeotti
It has been proposed that depression is associated with dysfunction of hippocampal plasticity. Novel hypotheses suggest that antidepressants induce neuronal structural plasticity, although the underlying mechanisms still remain unclear. Therefore, the aim of this study was to investigate the effects of amitriptyline on levels of phosphorylated heavy neurofilament subunit (NF-H) in the hippocampus of mice exposed to acute and chronic behavioral despair paradigms. Immunoblotting experiments showed that animals exposed to the tail suspension test (TST) displayed diminished levels of pNF-H 24h after testing...
November 3, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27810136/when-body-mass-index-fails-to-measure-up-perinephric-and-periumbilical-fat-as-predictors-of-operative-risk
#9
Luke Martin, Gillian Seton, Booth Aldred, Paul Hopkins, Jessica Chan, Marta E Heilbrun, Mary Mone, Courtney Scaife, William Peche
BACKGROUND: Obesity has been associated with worse outcomes and increased surgical technical difficulty. Perinephric fat (PNF) and periumbilical fat (PUF) are alternative metrics to body mass index. We hypothesized that PUF and PNF would offer improved prediction of perioperative risk. METHODS: 249 patients were retrospectively reviewed after elective, pelvic colorectal resections. PNF and PUF were collected using axial imaging. Operative risk measurements included estimated blood loss (EBL) and operative time (OT)...
September 28, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27802245/progesterone-treatment-shows-greater-protection-in-brain-vs-retina-in-a-rat-model%C3%A2-of-middle-cerebral-artery-occlusion-progesterone-receptor-levels-may-play-an-important-role
#10
Rachael S Allen, Iqbal Sayeed, Yuliya Oumarbaeva, Katherine C Morrison, Paul H Choi, Machelle T Pardue, Donald G Stein
BACKGROUND/OBJECTIVE: To determine whether inflammation increases in retina as it does in brain following middle cerebral artery occlusion (MCAO), and whether the neurosteroid progesterone, shown to have protective effects in both retina and brain after MCAO, reduces inflammation in retina as well as brain. METHODS: MCAO rats treated systemically with progesterone or vehicle were compared with shams. Protein levels of cytosolic NF-κB, nuclear NF-κB, phosphorylated NF-κB, IL-6, TNF-α, CD11b, progesterone receptor A and B, and pregnane X receptor were assessed in retinas and brains at 24 and 48 h using western blots...
October 13, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27791345/a-randomized-controlled-trial-on-the-long-term-effects-of-proprioceptive-neuromuscular-facilitation-training-on-pain-related-outcomes-and-back-muscle-activity-in-patients-with-chronic-low-back-pain
#11
Pattanasin Areeudomwong, Witchayut Wongrat, Nertnapa Neammesri, Thanaporn Thongsakul
BACKGROUND: The role of exercise therapy in improving pain-related clinical outcomes and trunk muscle activity in patients with chronic low back pain (CLBP) has been widely reported. There is little information on the effect of proprioceptive neuromuscular facilitation (PNF) training in patients with CLBP. The purpose of the present study was therefore to investigate the persistence of the effects of PNF training on pain intensity, functional disability, patient satisfaction, health-related quality of life (HRQOL) and lower back muscle activity in patients with CLBP...
October 28, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27783454/successful-donation-after-cardiac-death-liver-transplants-with-prolonged-warm-ischemia-time-using-normothermic-regional-perfusion
#12
R De Carlis, S Di Sandro, A Lauterio, F Ferla, A Dell'Acqua, M Zanierato, L De Carlis
The role of donation after cardiac death (DCD) in expanding the donor pool is mainly limited by the incidence of primary non-function (PNF) and ischemia-related complications. Even greater concern exists towards uncontrolled DCD, which represents the largest potential pool of DCD donors. We recently started the first Italian series of DCD liver transplantation, using normothermic regional perfusion (NRP) in 6 uncontrolled donors and in 1 controlled case to deal with the legally required no-touch period of 20 minutes...
October 26, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27749583/maximizing-kidneys-for-transplantation-using-machine-perfusion-from-the-past-to-the-future-a-comprehensive-systematic-review-and-meta-analysis
#13
Ahmer M Hameed, Henry C Pleass, Germaine Wong, Wayne J Hawthorne
BACKGROUND: The two main options for renal allograft preservation are static cold storage (CS) and machine perfusion (MP). There has been considerably increased interest in MP preservation of kidneys, however conflicting evidence regarding its efficacy and associated costs have impacted its scale of clinical uptake. Additionally, there is no clear consensus regarding oxygenation, and hypo- or normothermia, in conjunction with MP, and its mechanisms of action are also debated. The primary aims of this article were to elucidate the benefits of MP preservation with and without oxygenation, and/or under normothermic conditions, when compared with CS prior to deceased donor kidney transplantation...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27705852/local-transverse-slice-based-level-set-method-for-segmentation-of-3d-high-frequency-ultrasonic-backscatter-from-dissected-human-lymph-nodes
#14
Thanh M Bui, Alain Coron, Jonathan Mamou, Emi Saegusa-Beecroft, Tadashi Yamaguchi, Eugene Yanagihara, Junji Machi, S Lori Bridal, Ernest J Feleppa
OBJECTIVE: To detect metastases in freshly excised human lymph nodes (LNs) using 3-dimensional (3D), high-frequency, quantitative ultrasound (QUS) methods, the LN parenchyma (LNP) must be segmented to preclude QUS analysis of data in regions outside the LNP and to compensate ultrasound attenuation effects due to overlying layers of LNP and residual perinodal fat (PNF). METHODS: After restoring saturated radio-frequency signals from PNF using an approach based on smoothing-cubic splines, the three regions, i...
September 28, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27666129/using-a-qualitative-approach-to-conceptualize-concerns-of-patients-with-neurofibromatosis-type-1-associated-plexiform-neurofibromas-pnf-across-the-lifespan
#15
Jin-Shei Lai, Sally E Jensen, Zabin S Patel, Robert Listernick, Joel Charrow
Neurofibromatosis Type 1 (NF1) plexiform neurofibromas (pNFs) are associated with a variety of symptoms and concerns that affect patients' quality of life (QOL), highlighting the value of incorporating the patients' perspective when evaluating treatment outcomes. To better conceptualize the experience of patients with pNFs, this qualitative study sought to identify the most important outcomes to assess from the perspective of patients, families, and clinicians. Clinicians, patients age 5 years old and above, and parents of patients aged 5-17 years participated in semi-structured interviews to elicit the pNF symptoms/concerns considered most important to assess...
September 26, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27632820/immediate-effects-of-pnf-stretching-programs-compared-to-passive-stretching-programs-for-hamstring-flexibility-a-critically-appraised-topic
#16
Kristian J Hill, Kendall P Robinson, Jennifer W Cuchna, Matthew C Hoch
No abstract text is available yet for this article.
August 24, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27589369/safety-limitations-of-fatty-liver-transplantation-can-be-extended-to-40-experience-of-a-single-centre-in-china
#17
Zhiyong Yu, Zhongquan Sun, Songfeng Yu, Lin Zhang, Xiaowen Feng, Mangli Zhang, Xiao Xu, Jian Wu, Jun Yu, Min Zhang, Yan Shen, Weilin Wang, Haiyang Xie, Lin Zhou, Zhenhua Tu, Sheng Yan, Shusen Zheng
BACKGROUND & AIMS: Liver transplantation is the only solution for terminal liver disease. This study aims to determine the association between severity of liver graft steatosis, as well as other risk factors, and poor prognosis of liver transplantation. METHODS: The degree of steatosis was analysed in 563 consecutive liver transplantation and classified by histological examination as M0 (0%), M1 (<30%), M2-1 (30%-39%), M2-2 (40%-49%), M2-3 (50%-59%) or M3 (≥60%)...
September 2, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27585746/the-influence-of-ndt-bobath-and-pnf-methods-on-the-field-support-and-total-path-length-measure-foot-pressure-cop-in-patients-after-stroke
#18
Jolanta Krukowska, Marcin Bugajski, Monika Sienkiewicz, Jan Czernicki
In stroke patients, the NDT - (Bobath - Neurodevelopmental Treatment) and PNF (Proprioceptive Neuromuscular Facilitation) methods are used to achieve the main objective of rehabilitation, which aims at the restoration of maximum patient independence in the shortest possible period of time (especially the balance of the body). The aim of the study is to evaluate the effect of the NDT-Bobath and PNF methods on the field support and total path length measure foot pressure (COP) in patients after stroke. The study included 72 patients aged from 20 to 69 years after ischemic stroke with Hemiparesis...
August 20, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27581036/metagenomic-analysis-of-some-potential-nitrogen-fixing-bacteria-in-arable-soils-at-different-formation-processes
#19
Agnieszka Wolińska, Agnieszka Kuźniar, Urszula Zielenkiewicz, Artur Banach, Dariusz Izak, Zofia Stępniewska, Mieczysław Błaszczyk
The main goal of the study was to determine the diversity of the potential nitrogen-fixing (PNF) bacteria inhabiting agricultural (A) soils versus wastelands serving as controls (C). The soils were classified into three groups based on the formation process: autogenic soils (Albic Luvisols, Brunic Arenosols, Haplic Phaeozem) formed on loess material, hydrogenic soils (Mollic Gleysols, Eutric Fluvisol, Eutric Histosol) formed under the effect of stagnant water and lithogenic soils (Rendzina Leptosols) formed on limestone...
August 31, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27543202/initial-poor-function-and-primary-nonfunction-in-deceased-donor-orthotopic-liver-transplantation-maintaining-short-cold-ischemic-time-what-is-the-influence-of-poor-donor-maintenance-notes-from-a-single-indian-center
#20
Somak Das, Sudeepta Kumar Swain, Pavan Kumar Addala, Ramakrishnan Balasubramaniam, C V Gopakumar, Dinesh Zirpe, Kirubakaran Renganathan, Harsha Kollu, Darshan Patel, Bipin B Vibhute, Prashantha S Rao, Elankumaran Krishnan, Mahesh Gopasetty, Anand K Khakhar, Anil Vaidya, Anand Ramamurthy
BACKGROUND: Nations with emerging deceased-donor liver transplantation programs, such as India, face problems associated with poor donor maintenance. Cold ischemic time (CIT) is typically maintained short by matching donor organ recovery and recipient hepatectomy to achieve maximum favorable outcome. We analyzed different extended criteria donor factors including donor acidosis, which may act as a surrogate marker of poor donor maintenance, to quantify the risk of primary nonfunction (PNF) or initial poor function (IPF)...
August 19, 2016: Progress in Transplantation
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