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https://www.readbyqxmd.com/read/29327440/a-maize-phytochrome-interacting-factors-protein-zmpif1-enhances-drought-tolerance-by-inducing-stomatal-closure-and-improves-grain-yield-in-oryza-sativa
#1
Yong Gao, Meiqin Wu, Mengjiao Zhang, Wei Jiang, Xiaoyun Ren, Enxing Liang, Dongping Zhang, Changquan Zhang, Ning Xiao, Yan Li, Yi Dai, Jianmin Chen
Phytochrome-interacting factors (PIFs) play major roles in regulating plant growth and development, but their roles in drought stress remain elusive. Here, we cloned and characterized a maize (Zea mays) PIF transcription factor, ZmPIF1. The expression level of ZmPIF1 was significantly induced by independent drought and abscisic acid (ABA) treatments. The ZmPIF1 transgenic rice and Arabidopsis displayed water-saving and drought-resistance, which were associated with reduced a stomatal aperture and transpiration rate...
January 11, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29286136/proteomic-investigation-of-the-effects-of-preimplantation-factor-on-human-embryo-implantation
#2
Min Yang, Yixuan Yang, Sha She, Sanglin Li
Despite the use of adjuvant therapies, the cumulative proportion of live births remains at ~40%. Accumulating data show that low pregnancy rates, even in the presence of high fertility rates, are due to implantation failure. The present study aimed to identify and construct a profile of proteins that react with preimplantation factor (PIF) and to provide an understanding into the molecular mechanisms by which PIF promotes trophoblast invasion. Cytoplasmic proteins were immunoprecipitated with biotin‑labeled synthetic PIF or intralipid and scrambled PIF (PIFscr)...
December 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29258424/divergent-regulation-of-arabidopsis-saur-genes-a-focus-on-the-saur10-clade
#3
Hilda van Mourik, Aalt D J van Dijk, Niek Stortenbeker, Gerco C Angenent, Marian Bemer
BACKGROUND: Small Auxin-Upregulated RNA (SAUR) genes encode growth regulators that induce cell elongation. Arabidopsis contains more than 70 SAUR genes, of which the growth-promoting function has been unveiled in seedlings, while their role in other tissues remained largely unknown. Here, we focus on the regulatory regions of Arabidopsis SAUR genes, to predict the processes in which they play a role, and understand the dynamics of plant growth. RESULTS: In this study, we characterized in detail the entire SAUR10-clade: SAUR8, SAUR9, SAUR10, SAUR12, SAUR16, SAUR50, SAUR51 and SAUR54...
December 19, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29244171/arabidopsis-mkk10-mpk6-mediates-red-light-regulated-opening-of-seedling-cotyledons-through-phosphorylation-of-pif3
#4
Xiaoyun Xin, Wenhao Chen, Bo Wang, Fan Zhu, Yuan Li, Hailian Yang, Jigang Li, Dongtao Ren
Photomorphogenesis is an important process in which seedlings emerge from soil and begin autotrophic growth. Mechanisms of photomorphogenesis include light signal perception, signal transduction, and the modulation of expression of light-responsive genes, ultimately leading to cellular and developmental changes. Phytochrome-interacting factors (PIFs) play negative regulatory roles in photomorphogenesis. Light-induced activation of phytochromes triggers rapid phosphorylation and degradation of PIFs, but the kinases responsible for the phosphorylation of PIFs are largely unknown...
December 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29243284/professional-paradox-identity-formation-in-qualified-doctors-pursuing-further-training
#5
Mercedes Chan, Dan Pratt, Gary Poole, Ravi Sidhu
CONTEXT: Many newly qualified specialists and subspecialists pursue additional training. Although their motivations are many, the pursuit of further training as an alternative to unemployment is an emerging trend. Paradoxically, doctors continue as trainees with a consultant's credentials, and without the guarantee of eventual employment. This study explores seven doctors' experiences, the effects of further training on their professional identity formation (PIF), and how these effects are reconciled on a personal and professional level...
December 15, 2017: Medical Education
https://www.readbyqxmd.com/read/29239489/how-many-melanomas-might-be-prevented-if-more-people-applied-sunscreen-regularly
#6
C M Olsen, L F Wilson, A C Green, N Biswas, J Loyalka, D C Whiteman
BACKGROUND: Ultraviolet radiation causes cutaneous melanoma. Sunscreen prevents sunburn and protects skin cells against mutations. High-quality epidemiological studies suggest regular sunscreen use prevents melanoma. OBJECTIVES: To calculate the potential impact fraction (PIF) for melanoma in the U.S.A. and Australia assuming a range of different intervention scenarios intended to increase sunscreen use. METHODS: We calculated the PIF, the proportional difference between the observed number of melanomas arising under prevailing levels of sunscreen use compared with the number expected under counterfactual scenarios...
December 14, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29237442/factors-impacting-the-illness-trajectory-of-post-infectious-fatigue-syndrome-a-qualitative-study-of-adults-experiences
#7
Eva Stormorken, Leonard A Jason, Marit Kirkevold
BACKGROUND: Post-infectious fatigue syndrome (PIFS), also known as post-viral fatigue syndrome, is a complex condition resulting in physical, cognitive, emotional, neurological, vocational and/or role performance disabilities in varying degrees that changes over time. The needs for health care resources are high, and costly, as is the economic burden on the affected individuals. Many factors may impact the trajectory, and frequently PIFS develops into a chronic condition. Health professionals lack understanding and knowledge, which results in delayed diagnosis, lack of recognition, appropriate treatment, support and practical help...
December 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29199270/mechanism-of-early-light-signaling-by-the-carboxy-terminal-output-module-of-arabidopsis-phytochrome-b
#8
Yongjian Qiu, Elise K Pasoreck, Amit K Reddy, Akira Nagatani, Wenxiu Ma, Joanne Chory, Meng Chen
Plant phytochromes are thought to transduce light signals by mediating the degradation of phytochrome-interacting transcription factors (PIFs) through the N-terminal photosensory module, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not participate in signaling. Here we show that the C-terminal module of Arabidopsis phytochrome B (PHYB) is sufficient to mediate the degradation of PIF3 specifically and to activate photosynthetic genes in the dark. The HKRD is a dimerization domain for PHYB homo and heterodimerization...
December 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/29191562/genetic-and-lifestyle-dependent-dental-caries-defined-by-the-acidic-proline-rich-protein-genes-prh1-and-prh2
#9
Nicklas Strömberg, Anders Esberg, Nongfei Sheng, Lena Mårell, Anna Löfgren-Burström, Karin Danielsson, Carina Källestål
Dental caries is a chronic infectious disease that affects billions of people with large individual differences in activity. We investigated whether PRH1 and PRH2 polymorphisms in saliva acidic proline-rich protein (PRP) receptors for indigenous bacteria match and predict individual differences in the development of caries. PRH1 and PRH2 variation and adhesion of indigenous and cariogenic (Streptococcus mutans) model bacteria were measured in 452 12-year-old Swedish children along with traditional risk factors and related to caries at baseline and after 5-years...
November 22, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29180698/dual-impact-of-elevated-temperature-on-plant-defence-and-bacterial-virulence-in-arabidopsis
#10
Bethany Huot, Christian Danve M Castroverde, André C Velásquez, Emily Hubbard, Jane A Pulman, Jian Yao, Kevin L Childs, Kenichi Tsuda, Beronda L Montgomery, Sheng Yang He
Environmental conditions profoundly affect plant disease development; however, the underlying molecular bases are not well understood. Here we show that elevated temperature significantly increases the susceptibility of Arabidopsis to Pseudomonas syringae pv. tomato (Pst) DC3000 independently of the phyB/PIF thermosensing pathway. Instead, elevated temperature promotes translocation of bacterial effector proteins into plant cells and causes a loss of ICS1-mediated salicylic acid (SA) biosynthesis. Global transcriptome analysis reveals a major temperature-sensitive node of SA signalling, impacting ~60% of benzothiadiazole (BTH)-regulated genes, including ICS1 and the canonical SA marker gene, PR1...
November 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29176087/in-pursuit-of-educational-integrity-professional-identity-formation-in-the-harvard-medical-school-cambridge-integrated-clerkship
#11
Elizabeth Gaufberg, David Bor, Perry Dinardo, Edward Krupat, Elizabeth Pine, Barbara Ogur, David A Hirsh
Graduates of Harvard Medical School's Cambridge Integrated Clerkship (CIC) describe several core processes that may underlie professional identity formation (PIF): encouragement to integrate pre-professional and professional identities; support for learner autonomy in discovering meaningful roles and responsibilities; learning through caring relationships; and a curriculum and an institutional culture that make values explicit. The authors suggest that the benefits of educational integrity accrue when idealistic learners inhabit an educational model that aligns with their own core values, and when professional development occurs in the context of an institutional home that upholds these values...
2017: Perspectives in Biology and Medicine
https://www.readbyqxmd.com/read/29170505/ilizarov-external-fixation-versus-plate-internal-fixation-in-the-treatment-of-end-stage-ankle-arthritis-decision-analysis-of-clinical-parameters
#12
Jun Li, Bohua Li, Zhengdong Zhang, Shanxi Wang, Lei Liu
The purpose of this study was to evaluate the effect of Ilizarov external fixation (IEF) and plate internal fixation (PIF) in the treatment of end-stage ankle arthritis on pain relieving and function improvement. The study cohort consisted of 59 patients with end-stage ankle arthritis underwent ankle arthrodesis with IEF or PIF between June 2011 and June 2015. Standard radiographs and computed tomography (CT) scans were obtained before surgery and during the follow-up. Functional assessments were performed using Foot and Ankle pain score of American Orthopedics Foot and Ankle Society (AOFAS) and Visual Analogue Scale (VAS)...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29139123/new-insights-into-the-mechanisms-of-phytochrome-cryptochrome-coaction
#13
REVIEW
Qin Wang, Qing Liu, Xu Wang, Zecheng Zuo, Yoshito Oka, Chentao Lin
Contents I. II. III. IV. SUMMARY: Plants perceive and respond to light signals by multiple sensory photoreceptors, including phytochromes and cryptochromes, which absorb different wavelengths of light to regulate genome expression and plant development. Photophysiological analyses have long revealed the coordinated actions of different photoreceptors, a phenomenon referred to as the photoreceptor coaction. The mechanistic explanations of photoreceptor coactions are not fully understood...
November 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/29134933/baculoviruses-require-an-intact-odv-entry-complex-to-resist-proteolytic-degradation-of-per-os-infectivity-factors-by-co-occluded-proteases-from-the-larval-host
#14
Bob Boogaard, Jan W M van Lent, David A Theilmann, Martin A Erlandson, Monique M van Oers
Baculoviruses orally infect caterpillars in the form of occlusion-derived viruses (ODVs). The ODV-envelope contains a number of proteins which are essential for oral infectivity, called per os infectivity factors (PIFs). Most of these PIFs are involved in the formation of an ODV-entry complex that consists of a stable core, formed by PIF1, PIF2, PIF3 and PIF4, and the more loosely associated PIFs P74 (PIF0) and P95 (PIF8). PIF1, PIF2 and PIF3 are essential for formation of the stable core, whereas deletion of the pif4 gene results in the formation of a smaller complex...
November 14, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29128910/allogeneic-ovarian-transplantation-using-immunomodulator-preimplantation-factor-pif-as-monotherapy-restored-ovarian-function-in-olive-baboon
#15
Michael Feichtinger, Eytan R Barnea, Atunga Nyachieo, Mats Brännström, S Samuel Kim
PURPOSE: Allogeneic ovarian transplantation may be an alternative in the future to oocyte donation in women with premature ovarian failure. The objectives of this study were to (a) evaluate allotransplantation feasibility for restoration of ovarian function and (b) assess efficacy of synthetic preimplantation factor (PIF) monotherapy as sole immune-acceptance regimen. METHODS: This is an experimental animal study using non-human primates (Papio anubis). Allogeneic orthotopic ovarian tissue transplantation was performed in two female olive baboons...
November 11, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29102134/inactivation-of-cronobacter-malonaticus-cells-and-inhibition-of-its-biofilm-formation-exposed-to-hydrogen-peroxide-stress
#16
Yingwang Ye, Maofeng Zhang, Rui Jiao, Na Ling, Xiyan Zhang, Liaowang Tong, Haiyang Zeng, Jumei Zhang, Qingping Wu
Presence of Cronobacter malonaticus in powdered infant formula (PIF) poses a high risk to infant and public health. Cronobacter malonaticus has been widely distributed in food and food processing environments, and the true origin of C. malonaticus in PIF is poorly understood. Control and prevention of C. malonaticus is necessary for achieving microbial safety of PIF. However, little information about decontamination of C. malonaticus is available. In this study, effects of hydrogen peroxide on inactivation and morphological changes of C...
October 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29089940/prevalence-molecular-characterization-and-antibiotic-susceptibility-of-cronobacter-sakazakii-isolates-from-powdered-infant-formula-collected-from-chinese-retail-markets
#17
Peng Fei, Yichao Jiang, Yan Jiang, Xiujuan Yuan, Tongxiang Yang, Junliang Chen, Ziyuan Wang, Huaibin Kang, Stephen J Forsythe
Cronobacter sakazakii is an opportunistic pathogen that causes severe infections in neonates and infants through contaminated powdered infant formula (PIF). Therefore, the aim of this study was a large-scale study on determine the prevalence, molecular characterization and antibiotic susceptibility of C. sakazakii isolates from PIF purchased from Chinese retail markets. Two thousand and twenty PIF samples were collected from different institutions. Fifty-six C. sakazakii strains were isolated, and identified using fusA sequencing analysis, giving a contamination rate of 2...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29078307/efficient-synthesis-of-phycocyanobilin-in-mammalian-cells-for-optogenetic-control-of-cell-signaling
#18
Youichi Uda, Yuhei Goto, Shigekazu Oda, Takayuki Kohchi, Michiyuki Matsuda, Kazuhiro Aoki
Optogenetics is a powerful tool to precisely manipulate cell signaling in space and time. For example, protein activity can be regulated by several light-induced dimerization (LID) systems. Among them, the phytochrome B (PhyB)-phytochrome-interacting factor (PIF) system is the only available LID system controlled by red and far-red lights. However, the PhyB-PIF system requires phycocyanobilin (PCB) or phytochromobilin as a chromophore, which must be artificially added to mammalian cells. Here, we report an expression vector that coexpresses HO1 and PcyA with Ferredoxin and Ferredoxin-NADP+ reductase for the efficient synthesis of PCB in the mitochondria of mammalian cells...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29073617/preimplantation-factor-pif-promotes-hla-g-e-f-c-expression-in-jeg-3-choriocarcinoma-cells-and-endogenous-progesterone-activity
#19
Miya Soukaina Hakam, Jose Maria Miranda-Sayago, Soren Hayrabedyan, Krassimira Todorova, Patrick Simon Spencer, Asma Jabeen, Eytan R Barnea, Nelson Fernandez
BACKGROUND/AIMS: Pregnancy success requires mandatory maternal tolerance of the semi/ allogeneic embryo involving embryo-derived signals. Expression levels of PreImplantation Factor (PIF), a novel peptide secreted by viable embryos, correlate with embryo development, and its early detection in circulation correlates with a favourable pregnancy outcome. PIF enhances endometrial receptivity to promote embryo implantation. Via the p53 pathway, it increases trophoblast invasion, improving cell survival / immune privilege...
October 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29066729/a-quantitative-model-of-the-phytochrome-pif-light-signalling-initiating-chloroplast-development
#20
Carole Dubreuil, Yan Ji, Åsa Strand, Andreas Grönlund
The components required for photosynthesis are encoded in two separate genomes, the nuclear and the plastid. To address how synchronization of the two genomes involved can be attained in early light-signalling during chloroplast development we have formulated and experimentally tested a mathematical model simulating light sensing and the following signalling response. The model includes phytochrome B (PhyB), the phytochrome interacting factor 3 (PIF3) and putative regulatory targets of PIF3. Closed expressions of the phyB and PIF3 concentrations after light exposure are derived, which capture the relevant timescales in the response of genes regulated by PIF3...
October 24, 2017: Scientific Reports
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