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https://www.readbyqxmd.com/read/28204924/genome-wide-analysis-of-transposable-elements-in-the-coffee-berry-borer-hypothenemus-hampei-coleoptera-curculionidae-description-of-novel-families
#1
Eric M Hernandez-Hernandez, Rita Daniela Fernández-Medina, Lucio Navarro-Escalante, Jonathan Nuñez, Pablo Benavides-Machado, Claudia M A Carareto
The coffee berry borer (CBB) Hypothenemus hampei is the most limiting pest of coffee production worldwide. The CBB genome has been recently sequenced; however, information regarding the presence and characteristics of transposable elements (TEs) was not provided. Using systematic searching strategies based on both de novo and homology-based approaches, we present a library of TEs from the draft genome of CBB sequenced by the Colombian Coffee Growers Federation. The library consists of 880 sequences classified as 66% Class I (LTRs: 46%, non-LTRs: 20%) and 34% Class II (DNA transposons: 8%, Helitrons: 16% and MITEs: 10%) elements, including families of the three main LTR (Gypsy, Bel-Pao and Copia) and non-LTR (CR1, Daphne, I/Nimb, Jockey, Kiri, R1, R2 and R4) clades and DNA superfamilies (Tc1-mariner, hAT, Merlin, P, PIF-Harbinger, PiggyBac and Helitron)...
February 15, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28183203/adverse-respiratory-effects-in-rats-following-inhalation-exposure-to-ammonia-respiratory-dynamics-and-histopathology
#2
Michael W Perkins, Benjamin Wong, Justin Tressler, Ashley Rodriguez, Katherine Sherman, Jaclynn Andres, Jennifer Devorak, William L Wilkins, Alfred M Sciuto
Acute respiratory dynamics and histopathology of the lungs and trachea following inhaled exposure to ammonia were investigated. Respiratory dynamic parameters were collected from male Sprague-Dawley rats (300-350 g) during (20 min) and 24 h (10 min) after inhalation exposure for 20 min to 9000, 20,000, and 23,000 ppm of ammonia in a head-only exposure system. Body weight loss, analysis of blood cells, and lungs and trachea histopathology were assessed 1, 3, and 24 h following inhalation exposure to 20,000 ppm of ammonia...
January 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28168719/acculturation-and-its-impact-on-the-oral-health-status-of-pacific-children-in-new-zealand-findings-from-the-pacific-islands-families-study
#3
Philip J Schluter, Sathananthan Kanagaratnam, Steve Taylor, El-Shadan Tautolo
OBJECTIVES: Immigration and acculturation are increasingly recognized as important explanatory factors for health disparities, although their impact on oral health is less well understood. This study investigates the relationship between Pacific children's cultural orientation and oral health, after adjusting for potentially moderating and confounding variables. METHODS: The Pacific Islands Families (PIF) study follows a cohort of Pacific infants born in 2000. PIF study participants' data from their last dental examination were extracted from service records, and matched to the cohort...
February 7, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28141558/results-of-auricular-conchal-bowl-reconstructions-following-cancer-resections-with-postauricular-island-flap
#4
Aleksandra Iljin, Edward Lewandowicz, Bogusław Antoszewski, Marcin Durko, Tomasz Zieliński
: The aim of the study was to present our experience with the postauricular island flap (pif) and clinical evaluation of the results following auricular conchal bowl reconstructions with the pif in patients after carcinoma resections. MATERIAL AND METHODS: We analyzed results in 13 patients who underwent auricular conchal bowl reconstructions with pif following malignant tumor resection between 2000-2013. The patients were followed-up. We estimated early and long-term results after surgery including plastic surgeon's and patient's opinion...
December 1, 2016: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28141488/protein-protein-interactions-of-the-baculovirus-per-os-infectivity-factors-in-the-pif-complex
#5
Qin Zheng, Yunwang Shen, Xiangshuo Kon, Jianjia Zhang, Min Feng, Xiaofeng Wu
After ingestion of occlusion bodies, the occlusion-derived viruses (ODVs) of baculoviruses establish the first round of infection within the larval host midgut cells. Several ODV envelope proteins, called per os infectivity factors (PIFs), have been shown to be essential for oral infection. Eight PIFs have been identified to date, including P74, PIFs1-6, and Ac110. At least six PIFs: P74, PIFs1-4, PIF6, together with three other ODV-specific proteins: Ac5, P95 (Ac83), and Ac108, have been reported to form a complex on the ODV surface...
January 28, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28123107/characterization-of-phytochrome-interacting-factors-from-the-moss-physcomitrella-patens-illustrates-conservation-of-phytochrome-signaling-modules-in-land-plants
#6
Anja Possart, Tengfei Xu, Inyup Paik, Sebastian Hanke, Sarah Keim, Helen-Maria Hermann, Luise Wolf, Manuel Hiss, Claude Becker, Enamul Huq, Stefan A Rensing, Andreas Hiltbrunner
Across the plant kingdom, phytochrome (PHY) photoreceptors play an important role during adaptive and developmental responses to light. In Arabidopsis thaliana, light-activated PHYs accumulate in the nucleus, where they regulate downstream signaling components, such as phytochrome interacting factors (PIFs). PIFs are transcription factors that act as repressors of photomorphogenesis; their inhibition by PHYs leads to substantial changes in gene expression. The nuclear function of PHYs, however, has so far been investigated in only a few non-seed plants...
January 25, 2017: Plant Cell
https://www.readbyqxmd.com/read/28123096/deep-conservation-of-bivalve-nacre-proteins-highlighted-by-shell-matrix-proteomics-of-the-unionoida-elliptio-complanata-and-villosa-lienosa
#7
Benjamin Marie, Jaison Arivalagan, Lucrèce Mathéron, Gérard Bolbach, Sophie Berland, Arul Marie, Frédéric Marin
The formation of the molluscan shell nacre is regulated to a large extent by a matrix of extracellular macromolecules that are secreted by the shell-forming tissue, the mantle. This so-called 'calcifying matrix' is a complex mixture of proteins, glycoproteins and polysaccharides that is assembled and occluded within the mineral phase during the calcification process. Better molecular-level characterization of the substances that regulate nacre formation is still required. Notable advances in expressed tag sequencing of freshwater mussels, such as Elliptio complanata and Villosa lienosa, provide a pre-requisite to further characterize bivalve nacre proteins by a proteomic approach...
January 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28117884/allogeneic-transplantation-for-advanced-acute-myeloid-leukemia-the-value-of-complete-remission
#8
Daniel J Weisdorf, Heather R Millard, Mary M Horowitz, Parvinder S Hyare, Richard Champlin, Vincent Ho, Marco Mielcarek, Andrew Rezvani, Keith Stockerl-Goldstein, Hanna J Khoury, Marcos De Lima, Wael Saber, Brenda Sandmaier, Mei Jie Zhang, Mary Eapen
BACKGROUND: Patients with acute myeloid leukemia (AML) without complete remission (CR) or in first relapse (Rel1) can have extended leukemia control and survival after allogeneic hematopoietic cell transplantation (HCT). For patients in Rel1 or primary induction failure (PIF), transplantation versus treatment to achieve a second CR (CR2) and subsequent HCT might yield similar outcomes, but available comparative data are scarce. METHODS: Survival was analyzed in 4682 HCT recipients according to disease status: PIF (N = 1440), Rel1 (failing ≥1 reinduction; N = 1256), and CR2 (N = 1986)...
January 24, 2017: Cancer
https://www.readbyqxmd.com/read/28106621/mortality-risk-reductions-from-substituting-screen-time-by-discretionary-activities
#9
Katrien Wijndaele, Stephen J Sharp, Nicholas J Wareham, Søren Brage
PURPOSE: Leisure-screen-time, including TV viewing, is associated with increased mortality risk. We estimated the all-cause mortality risk reductions associated with substituting leisure-screen-time with different discretionary physical activity types, and the change in mortality incidence associated with different substitution scenarios. METHODS: 423,659 UK Biobank participants, without stroke, myocardial infarction or cancer history, were followed for 7.6 (1.4) (median (IQR)) years...
January 19, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28103531/characterization-of-transcriptome-and-identification-of-biomineralization-genes-in-winged-pearl-oyster-pteria-penguin-mantle-tissue
#10
Haimei Li, Baosuo Liu, Guiju Huang, Sigang Fan, Bo Zhang, Jiaqi Su, Dahui Yu
The winged pearl oyster Pteria penguin is a commercially important marine pearl oyster species, with pearls that are quite different from those of other pearl oysters. Among such species, mantle tissue is the main organ responsible for shell and pearl formation, a biomineralization process that is regulated by a series of genes, most of which remain unknown. In this study, we sequenced and characterized the transcriptome of P. penguin mantle tissue using the HiSeq 2000 sequencing platform. A total of 93,204 unique transcripts were assembled from 51,580,076 quality reads, with a mean length of 608bp, and 40,974 unigenes were annotated...
January 8, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28102581/molecular-mechanisms-and-ecological-function-of-far-red-light-signalling
#11
REVIEW
David J Sheerin, Andreas Hiltbrunner
Land plants possess the ability to sense and respond to far-red light (700-760 nm), which serves as an important environmental cue. Due to the nature of far-red light, it is not absorbed by chlorophyll and thus is enriched in canopy shade, and will also penetrate deeper into soil than other visible wavelengths. Far-red light responses include regulation of seed germination, suppression of hypocotyl growth, induction of flowering, and accumulation of anthocyanins, which depend on one member of the phytochrome photoreceptor family, phytochrome A (phyA)...
January 19, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28093768/short-term-and-long-term-follow-up-of-pulmonary-function-in-patients-with-copd-after-total-laryngectomy-a-prospective-study
#12
Charlotte Schönwald, Maria Isabel Körber, Dirk Beutner, Roman Pfister, Konrad Frank, Orlando Guntinas-Lichius, Guido Michels
OBJECTIVE: There exists no standardized method for examining lung function in laryngectomized patients. STUDY DESIGN AND METHODS: We established a base plate adapter (BPA) system for patients after laryngectomy. In 10 patients with chronic obstructive pulmonary disease (COPD), we evaluated pulmonary function before laryngectomy, as well as 2 weeks and 3 months after laryngectomy. RESULTS: The BPA system was well tolerated and delivered reliable results comparable to measurements with a mouthpiece...
January 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28045490/an-allosteric-inhibitor-scaffold-targeting-the-pif-pocket-of-atypical-protein-kinase-c-isoforms
#13
Jose M Arencibia, Wolfgang Fröhner, Magdalena Krupa, Daniel Pastor-Flores, Piotr Merker, Thomas Oellerich, Sonja Neimanis, Christian Schmithals, Verena Köberle, Evelyn Süß, Stefan Zeuzem, Holger Stark, Albrecht Piiper, Dalibor Odadzic, Jörg O Schulze, Ricardo M Biondi
There is a current and pressing need for improved cancer therapies. The use of small molecule kinase inhibitors and their application in combinatorial regimens represent an approach to personalized targeted cancer therapy. A number of AGC kinases, including atypical Protein Kinase C enzymes (PKCs), are validated drug targets for cancer treatment. Most drug development programs for protein kinases focus on the development of drugs that bind at the ATP-binding site. Alternatively, allosteric drugs have great potential for the development of future innovative drugs...
January 13, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28033728/measuring-professional-identity-formation-early-in-medical-school
#14
Adina Kalet, Lynn Buckvar-Keltz, Victoria Harnik, Verna Monson, Steven Hubbard, Ruth Crowe, Hyuksoon S Song, Sandra Yingling
AIM: To assess the feasibility and utility of measuring baseline professional identity formation (PIF) in a theory-based professionalism curriculum for early medical students. METHODS: All 132 entering students completed the professional identity essay (PIE) and the defining issues test (DIT2). Students received score reports with individualized narrative feedback and wrote a structured reflection after a large-group session in which the PIF construct was reviewed...
December 30, 2016: Medical Teacher
https://www.readbyqxmd.com/read/28031365/acmnpv-ac83-is-a-pif-protein-required-for-odv-and-bv-nucleocapsid-assembly-as-well-as-assembly-of-the-pif-complex-in-odv-envelopes
#15
Muhammad Afzal Javed, Siddhartha Biswas, Leslie G Willis, Stephanie Harris, Caitlin Pritchard, Monique M van Oers, B Cameron Donly, Martin A Erlandson, Dwayne D Hegedus, David A Theilmann
: Baculovirus occlusion derived virus (ODV) initiate infection of lepidopteran larval hosts by binding to the midgut epithelia which is mediated by per os infectivity factors (PIFs). Autographa californica multiple nucleopolyhedrovirus (AcMNPV) encodes seven PIF proteins of which PIF1-4 form a core complex in ODV envelopes to which PIF0 and PIF6 loosely associate. Deletion of any pif results in ODV unable to bind or enter midgut cells. AC83 also associates with the PIF complex and this study further analyzed its role in oral infectivity to determine if it is a PIF protein...
December 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/28028187/evaluating-the-effectiveness-of-written-dry-powder-inhaler-instructions-and-health-literacy-in-subjects-diagnosed-with-copd
#16
Hana J Alsomali, David L Vines, Brian D Stein, Ellen A Becker
BACKGROUND: Improper inhaler use results in decreased drug deposition in the lungs. The impact of health literacy and poor vision on the patient's ability to learn inhaler technique by reading instructions has not been confirmed. This study evaluated the effectiveness of learning inhaler technique from written instructions and the impact of health literacy for patients diagnosed with COPD who used a dry powder inhaler (DPI). METHODS: This pilot study recruited subjects diagnosed with COPD...
February 2017: Respiratory Care
https://www.readbyqxmd.com/read/28012621/development-and-application-of-a-sensitive-rapid-and-reliable-immunomagnetic-separation-pcr-detection-method-for-cronobacter-spp
#17
Qiming Chen, Yuanhong Li, Tingting Tao, Xiaomei Bie, Fengxia Lu, Zhaoxin Lu
Cronobacter spp. have been linked to clinical cases of infection in both adults and infants. Enrichment of Cronobacter spp. before detection has been necessary but is quite time consuming. Hence, we sought to develop an immunomagnetic separation (IMS) PCR method that could shorten the time of enrichment before the detection of Cronobacter spp. The polyclonal antibody used in this immunomagnetic separation was prepared based on the outer membrane protein A of Cronobacter sakazakii China Center of Industrial Culture Collection 21560 and had high specificity to the target...
February 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27987057/transcriptome-analysis-of-the-freshwater-pearl-mussel-cristaria-plicata-mantle-unravels-genes-involved-in-the-formation-of-shell-and-pearl
#18
Xuefeng Wang, Zhiming Liu, Wenjian Wu
Cristaria plicata, a bivalve widespread in Eastern Asia fresh water, is utilized as the freshwater pearl mussel in China. With a high economic value in pearl production, it is also an ideal object used for the studies on biomineralization in freshwater. In the research, we performed a large-scale sequencing of Cristaria plicata mantle transcriptome using Illumina HiSeq™ 2500, obtaining 98,501 unigenes with 67,817,724 bases. 22.28 and 16.64% of the unigenes were annotated in the NR and Swiss-Prot databases, respectively...
December 16, 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27943294/laryngeal-pacing-for-bilateral-vocal-fold-paralysis-voice-and-respiratory-aspects
#19
Andreas H Mueller, Rudolf Hagen, Claus Pototschnig, Gerhard Foerster, Wilma Grossmann, Katrin Baumbusch, Markus Gugatschka, Tadeus Nawka
OBJECTIVE: To evaluate the effects of neurostimulation with the laryngeal pacemaker (LP) system in patients with bilateral vocal fold paralysis (BVFP) in terms of voice quality and respiratory function. STUDY DESIGN: Feasibility study, first-in-human, single-arm, open-label, prospective, multicenter study with group-sequential design and 6-month follow-up period, as described in details in our previous publication. METHODS: Nine symptomatic BVFP subjects were unilaterally implanted with the LP system at three study sites in Germany and Austria...
December 10, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27936142/gene-co-expression-network-analysis-unraveling-transcriptional-regulation-of-high-altitude-adaptation-of-tibetan-pig
#20
Cunling Jia, Xiaoyan Kong, James E Koltes, Xiao Gou, Shuli Yang, Dawei Yan, Shaoxiong Lu, Zehui Wei
Tibetan pigs have survived at high altitude for millennia and they have a suite of adaptive features to tolerate the hypoxic environment. However, the molecular mechanisms underlying the regulation of hypoxia-adaptive phenotypes have not been completely elucidated. In this study, we analyzed differentially expressed genes (DEGs), biological pathways and constructed co-expression regulation networks using whole-transcriptome microarrays from lung tissues of Tibetan and Duroc pigs both at high and low altitude...
2016: PloS One
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