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https://www.readbyqxmd.com/read/29679921/electromyographic-and-biomechanical-analysis-of-step-negotiation-in-charcot-marie-tooth-subjects-whose-level-walk-is-not-impaired
#1
Tiziana Lencioni, Giuseppe Piscosquito, Marco Rabuffetti, Enrica Di Sipio, Manuela Diverio, Isabella Moroni, Luca Padua, Emanuela Pagliano, Angelo Schenone, Davide Pareyson, Maurizio Ferrarin
BACKGROUND: Charcot-Marie-Tooth (CMT) is a slowly progressive disease characterized by muscular weakness and wasting with a length-dependent pattern. Mildly affected CMT subjects showed slight alteration of walking compared to healthy subjects (HS). RESEARCH QUESTION: To investigate the biomechanics of step negotiation, a task that requires greater muscle strength and balance control compared to level walking, in CMT subjects without primary locomotor deficits (foot drop and push off deficit) during walking...
April 13, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29679725/achyranthis-bidentatae-radix-enhanced-articular-distribution-and-anti-inflammatory-effect-of-berberine-in-sanmiao-wan-using-an-acute-gouty-arthritis-rat-model
#2
Juan Wu, Jingya Li, Wei Li, Bei Sun, Jin Xie, Wenming Cheng, Qunlin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Sanmiao Wan (SMW) has been a basic prescription employed for the treatment for gout in the clinic since Yuan dynasty. Achyranthis bidentatae radix (ABR) is designed as a lower-guiding drug in SMW to augment the articular accumulation of active ingredients and improve the anti-inflammatory effect. AIM OF THE STUDY: Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR...
April 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29679687/a-novel-technique-indocyanine-green-angiography-to-prognosticate-healing-of-foot-ulcer-in-critical-limb-ischemia
#3
Hiten M Patel, Shahzad S Bulsara, Shubhabrata Banerjee, Tapish Sahu, Virender K Sheorain, Tarun Grover, Rajiv Parakh
BACKGROUND: To predict wound healing in patients with critical limb ischemia(CLI) is ongoing issue. Currents methods like ankle-brachial index (ABI), color doppler and transcutaneous oxygen pressure (TCPO2 ), CT angiography are lacking in demonstrating regional perfusion. Indocyanine green angiography (ICGA) has the potential to provide regional perfusion information lacking in other methods. To demonstrate successes of revascularization procedure in CLI patients based on ICGA data this study was conducted...
April 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29679362/anatomical-variation-in-the-form-of-inter-and-intra-individual-laterality-of-the-calcaneofibular-ligament
#4
Hisayoshi Yoshizuka, Kentaro Shibata, Toyoko Asami, Akio Kuraoka
The lateral ligament complex of the ankle is involved in a large proportion of ankle sprains. The calcaneofibular ligament (CFL) is often involved in severe injuries. The purpose of this study was to evaluate the anatomical variation and laterality of the CFL to improve our understanding of the mechanisms of CFL-related injuries. This study utilized 110 paired ankles from 55 formalin-fixed Japanese cadavers (33 male and 22 female). The length and width of the CFL and the angle created by the CFL and long axis of the fibula (CF angle) were measured after exposing the CFL by careful dissection from the surrounding tissues...
April 20, 2018: Anatomical Science International
https://www.readbyqxmd.com/read/29679256/biomechanical-features-of-six-design-of-the-delta-external-fixator-for-treating-pilon-fracture-a-finite-element-study
#5
Muhammad Hanif Ramlee, Mohd Ayub Sulong, Evelyn Garcia-Nieto, Daniel Angure Penaranda, Antonio Ros Felip, Mohammed Rafiq Abdul Kadir
Pilon fractures can be caused by high-energy vertical forces which may result in long-term patient immobilization. Many experts in orthopedic surgery recommend the use of a Delta external fixator for type III Pilon fracture treatment. This device can promote immediate healing of fractured bone, minimizing the rate of complications as well as allowing early mobilization. The characteristics of different types of the Delta frame have not been demonstrated yet. By using the finite element method, this study was conducted to determine the biomechanical characteristics of six different configurations (Model 1 until Model 6)...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29678685/success-rate-and-factors-predictive-of-redo-radiofrequency-ablation-of-perforator-veins
#6
Afsha Aurshina, Enrico Ascher, Lauren Mount, Amrit Hingorani, Natalie Marks, Anil Hingorani
OBJECTIVE: Radiofrequency ablation (RFA) is increasingly being employed for treatment of perforator vein insufficiency and venous ulcer healing. Previous studies have shown a closure rate of 60% to 80% in incompetent perforator veins (IPVs) with RFA. The purpose of the study was to determine the utility of a redo RFA for symptomatic recanalized perforators and to predict factors associated with recanalization. METHODS: A retrospective analysis of 642 procedures in 256 patients with venous insufficiency due to IPVs from 2009 to 2015 was conducted...
April 17, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29678649/nine-month-outcomes-of-the-durability-iliac-study-on-self-expanding-stents-for-symptomatic-peripheral-artery-disease
#7
Peter Faries, Michael Jaff, Patrick Peeters, Yazan Khatib, David Roberts, Marc Bosiers, Rajesh Malik, Reid Ravin, John Rundback
OBJECTIVE: The DURABILITY Iliac clinical study evaluated the safety and effectiveness of two nitinol self-expanding stents for the treatment of atherosclerotic common and external iliac artery lesions up to 10 cm in length and >50% stenosis in subjects with Rutherford Classification peripheral arterial disease stages 2-4. METHODS: DURABILITY Iliac was a prospective, multicenter, core lab adjudicated, nonrandomized clinical study enrolling 75 subjects from 15 sites in the United States and Europe...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29678601/motor-transfer-from-the-corticospinal-to-the-corticobulbar-pathway
#8
Alayna E Ernster, Seoung Hoon Park, Basma K Yacoubi, Evangelos A Christou, Agostina Casamento-Moran, Michele L Singer, Ianessa A Humbert
There are multiple descending neural pathways, including the corticospinal pathway (CS) and the corticobulbar pathway (CB). The corticospinal pathway has been shown to exhibit within-pathway (CS-to-CS) motor transfer. However, motor transfer across each pathway (CS-to-CB or CB-to-CS) has yet to be studied in depth. The aim of the present study was to examine the effects of cross-pathway motor transfer between the ankle (CS) and tongue (CB) after training with a ballistic goal-directed motor task. Twelve healthy participants were recruited for this two-day experimental study...
April 17, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29678417/comparison-of-knee-injury-threshold-during-tibial-compression-based-on-limb-orientation-in-mice
#9
Allison W Hsia, Franklin D Tarke, Trevor J Shelton, Priscilla M Tjandra, Blaine A Christiansen
Our previous studies used tibial compression overload to induce anterior cruciate ligament (ACL) rupture in mice, while others have applied similar or greater compressive magnitudes without injury. The causes of these differences in injury threshold are not known. In this study, we compared knee injury thresholds using a "prone configuration" and a "supine configuration" that differed with respect to hip, knee, and ankle flexion, and utilized different fixtures to stabilize the knee. Right limbs of female and male C57BL/6 mice were loaded using the prone configuration, while left limbs were loaded using the supine configuration...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29678138/an-anthropometric-study-of-distal-tibiofibular-syndesmosis-dts-in-a-chinese-population
#10
Mingyang Yu, Yao Zhang, Yun Su, Feng Wang, Dewei Zhao
BACKGROUND: To improve the diagnostic accuracy of distal tibiofibular syndesmoses (DTS), this study quantified the range in variations of the normal DTS in a Chinese population, based on CT scan images. METHODS: The study population comprised 92 patients with unilateral ankle injury. CT scans included the non-injured contralateral DTS. The position of the fibula relative to the fibular notch (incisure) of the tibia was quantified by inclusion or separation indices, based on whether the fibula was within or outside the fibular incisure, respectively...
April 20, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29677566/association-between-cumberland-ankle-instability-tool-score-and-postural-stability-in-collegiate-soccer-players-with-and-without-functional-ankle-instability
#11
Shun Kunugi, Akihiko Masunari, Naruto Yoshida, Shumpei Miyakawa
OBJECTIVE: The purpose of this study was to investigate the association between Cumberland Ankle Instability Tool (CAIT) scores and postural stability during a diagonal landing, and to investigate whether postural stability is altered in collegiate soccer players with and without functional ankle instability (FAI). DESIGN: Cross-sectional study. SETTING: Laboratory. PARTICIPANTS: Ninety-one soccer players were classified into a FAI group (history of at least two ankle sprains and a CAIT-Japanese version score ≤25, n = 28), a copers group (history of one ankle sprain and a CAIT-Japanese version score ≥26, n = 32), or a control group (no history of ankle sprain, n = 31)...
March 23, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29676167/validation-of-a-new-device-for-measuring-isolated-gastrocnemius-contracture-and-evaluation-of-the-reliability-of-the-silfverski%C3%A3-ld-test
#12
Marius Molund, Elisabeth Ellingsen Husebye, Fredrik Nilsen, Jan Hellesnes, Gøran Berdal, Kjetil Harald Hvaal
BACKGROUND: Important aspects on the diagnostics of isolated gastrocnemius contractures (IGCs) have been poorly described. This study was designed to validate a new ankle range of motion (ROM) measuring device for diagnosing an IGC. In addition, we wanted to investigate the reliability of the clinical Silfverskiöld test. METHODS: Twelve health care personnel (24 feet) were examined by 4 testers on 3 different occasions for the reliability testing of the new ankle ROM measuring device...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29675978/measurement-of-large-strain-properties-in-calf-muscles-in-vivo-using-magnetic-resonance-elastography-and-spatial-modulation-of-magnetization
#13
Kristy Tan, Lauriane Jugé, Alice Hatt, Shaokoon Cheng, Lynne E Bilston
It is important to measure the large deformation properties of skeletal muscle in vivo in order to understand and model movement and the force-producing capabilities of muscle. As muscle properties are non-linear, an understanding of how the deformation state affects the measured shear moduli is also useful for clinical applications of magnetic resonance elastography (MRE) to muscle disorders. MRE has so far only been used to measure the linear viscoelastic (small strain) properties of muscles. This study aims to measure the shear moduli of human calf muscles under varying degrees of strain using MRE...
April 19, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29675509/giant-cells-osseous-tumor-in-the-tarsal-canal-after-lateral-ankle-sprain
#14
Marcello Lughi
Ankle sprain can cause injuries to the anatomic structures surrounding the tibiotarsal joint. A possible extra-articular pathology is to be hypothesized and diagnosed as early as possible. The subtalar joint, for anatomical and functional reasons, is one of the most damaged joints following an ankle sprain. In spite of this, its involvement is often underestimated. The clinical case presented in the present article is referred to a giant cells osseous tumor in the tarsal canal that was diagnosed 2 months after an inversion ankle sprain...
March 2018: Joints
https://www.readbyqxmd.com/read/29675142/reviewing-clinical-effectiveness-of-active-training-strategies-of-platform-based-ankle-rehabilitation-robots
#15
REVIEW
Xiangfeng Zeng, Guoli Zhu, Mingming Zhang, Sheng Q Xie
Objective: This review aims to provide a systematical investigation of clinical effectiveness of active training strategies applied in platform-based ankle robots. Method: English-language studies published from Jan 1980 to Aug 2017 were searched from four databases using key words of "Ankle∗ " AND "Robot∗ " AND "Effect∗ OR Improv∗ OR Increas∗ ." Following an initial screening, three rounds of discrimination were successively conducted based on the title, the abstract, and the full paper...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29674644/aggressive-natural-killer-cell-leukemia-mutational-landscape-and-drug-profiling-highlight-jak-stat-signaling-as-therapeutic-target
#16
Olli Dufva, Matti Kankainen, Tiina Kelkka, Nodoka Sekiguchi, Shady Adnan Awad, Samuli Eldfors, Bhagwan Yadav, Heikki Kuusanmäki, Disha Malani, Emma I Andersson, Paavo Pietarinen, Leena Saikko, Panu E Kovanen, Teija Ojala, Dean A Lee, Thomas P Loughran, Hideyuki Nakazawa, Junji Suzumiya, Ritsuro Suzuki, Young Hyeh Ko, Won Seog Kim, Shih-Sung Chuang, Tero Aittokallio, Wing C Chan, Koichi Ohshima, Fumihiro Ishida, Satu Mustjoki
Aggressive natural killer-cell (NK-cell) leukemia (ANKL) is an extremely aggressive malignancy with dismal prognosis and lack of targeted therapies. Here, we elucidate the molecular pathogenesis of ANKL using a combination of genomic and drug sensitivity profiling. We study 14 ANKL patients using whole-exome sequencing (WES) and identify mutations in STAT3 (21%) and RAS-MAPK pathway genes (21%) as well as in DDX3X (29%) and epigenetic modifiers (50%). Additional alterations include JAK-STAT copy gains and tyrosine phosphatase mutations, which we show recurrent also in extranodal NK/T-cell lymphoma, nasal type (NKTCL) through integration of public genomic data...
April 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29674475/effect-of-sfrp5-secreted-frizzled-related-protein-5-on-the-wnt5a-wingless-type-family-member-5a-induced-endothelial-dysfunction-and-its-relevance-with-arterial-stiffness-in-human-subjects
#17
Yun Kyung Cho, Yu Mi Kang, Seung Eun Lee, Yoo La Lee, So Mi Seol, Woo Je Lee, Joong-Yeol Park, Chang Hee Jung
OBJECTIVE: SFRP5 (secreted frizzled-related protein 5) is an endogenous inhibitor of WNT5A (wingless-type family member 5a), which has been implicated in atherosclerosis. However, contradictory results have been reported about the role of SFRP5 in atherosclerosis. We aimed to investigate whether SFRP5 could restore WNT5A-induced endothelial dysfunction in vitro and ex vivo. In addition, we sought to determine whether the serum concentration of SFRP5 is associated with atherosclerosis in humans...
April 19, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29674285/evaluation-of-muscle-strength-balance-and-functionality-of-individuals-with-type-2-charcot-marie-tooth-disease
#18
Iandra Maria Pinheiro de França Costa, Paula Santos Nunes, Eduardo Luis de Aquino Neves, Lidiane Carine Lima Santos Barreto, Catarina Andrade Garcez, Cynthia Coelho Souza, Paulo Márcio Pereira Oliveira, Luiz Augusto Sales Ferreira, Viviane Nascimento Brandão Lima, Adriano Antunes de Souza Araújo
BACKGROUND: Charcot-Marie-Tooth (CMT) disease is part of a group of genetically determined neuropathies. The intrinsic muscles of the feet and legs are affected early in the disease, impacting balance and mobility. RESEARCH QUESTION: The purpose of this study was to evaluate individuals with type 2 Charcot-Marie-Tooth disease to understand how motor changes interfere in balance and function. METHODS: The sample comprised 15 individuals with CMT2 from the same family (CMT2G) and a control group (CG) of healthy individuals matched for age and gender...
April 5, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29674134/higher-dietary-acid-load-is-associated-with-higher-likelihood-of-peripheral-arterial-disease-among-american-adults
#19
Mohsen Mazidi, Dimitri P Mikhailidis, Maciej Banach
OBJECTIVE: To explore the association between dietary acid load, potential renal acid load (PRAL) and net endogenous acid production (NEAP), and peripheral arterial disease (PAD) in a national representative sample of American adults. METHODS: The National Health and Nutrition Examination Survey (NHANES) database (for 1999-2002) was used. PAD was diagnosed by ankle brachial index assessment. Analysis of covariance was used to examine adjusted mean of different dietary acid load by PAD status; multivariable logistic regression was used to relate dietary acid load with prevalent PAD...
March 9, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29673820/extra-osseous-ewing-s-sarcoma-of-sciatic-nerve-masquerading-as-benign-nerve-sheath-tumor-and-presented-as-lumbar-radiculopathy
#20
Jung Soo Bang, Nitin Adsul, Jae-Hyeon Lim, Il-Tae Jang
BACKGROUND: Extraosseous Ewing Sarcoma (EES) arising from peripheral nerves is extremely rare with only 11 cases, mentioned in the literature. It poses a diagnostic challenge to the clinicians due to its nonspecific presentation and rare occurrence. CASE DESCRIPTION: A 56-year-old woman came with a history of low back pain and intractable right leg pain. Physical examination revealed the normal motor power of both lower limbs with decreased sensation along the lateral aspect of the foot with decreased ankle reflex...
April 16, 2018: World Neurosurgery
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