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https://www.readbyqxmd.com/read/29656330/risk-factors-for-anatomic-pelvic-organ-prolapse-at-6-weeks-postpartum-a-prospective-observational-study
#1
Cathrine Reimers, Franziska Siafarikas, Jette Stær-Jensen, Milada Cvancarova Småstuen, Kari Bø, Marie Ellström Engh
INTRODUCTION AND HYPOTHESIS: The objective was to identify risk factors for postpartum anatomic pelvic organ prolapse (aPOP) by comparing women with and without aPOP at 6 weeks postpartum with regard to pelvic floor measurements antepartum and obstetrical characteristics. METHODS: We carried out a prospective observational cohort study including nulliparous pregnant women in a Norwegian university hospital. Participants underwent clinical examinations, including pelvic organ prolapse quantification system (POP-Q) and transperineal ultrasound at gestational week 21 and at 6 weeks postpartum...
April 14, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29656317/inflammatory-response-of-pulmonary-artery-smooth-muscle-cells-exposed-to-oxidative-and-biophysical-stress
#2
Joanna Costa, Yan Zhu, Timothy Cox, Paul Fawcett, Thomas Shaffer, Deepthi Alapati
Pulmonary hypertension in the neonate requires treatment with oxygen and positive pressure ventilation, both known to induce lung injury. The direct response of pulmonary artery smooth muscle cells, the most abundant cells in the artery wall, to the stress of positive pressure and hyperoxia has not been previously studied. Pulmonary artery smooth muscle cells were cultured in temperature- and pressure-controlled air-tight chambers under conditions of positive pressure or hyperoxia for 24 h. Control cells were cultured in room air under atmospheric pressure...
April 14, 2018: Inflammation
https://www.readbyqxmd.com/read/29656185/exogenous-serp1-attenuates-restenosis-by-restoring-glp-1-receptor-activity-in-diabetic-rats-following-vascular-injury
#3
Lishuai Feng, Jianbo Wang, Xu Ma
The activity of glucagon-like peptide 1 (GLP-1R) is essential for preventing restenosis following vascular injury; however, the mechanism of dysfunctional GLP-1R glycosylation and ways to enhance the activity of GLP-1R on vascular surfaces in diabetic patients are poorly understood. In the present study, we investigated the N-glycosylation level and role of stress-associated endoplasmic reticulum protein 1 (SERP1) in preventing restenosis following carotid injury in diabetic rats. Our results showed that N-glycosylation levels in both rat aortic endothelial cells (RAOECs) and rat vascular smooth muscle cells (VSMCs) decreased gradually following glucose treatment in a concentration dependant manner...
April 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29653187/mid-cervical-spinal-cord-contusion-causes-robust-deficits-in-respiratory-parameters-and-pattern-variability
#4
Philippa M Warren, Cara Campanaro, Frank J Jacono, Warren J Alilain
Mid-cervical spinal cord contusion disrupts both the pathways and motoneurons vital to the activity of inspiratory muscles. The present study was designed to determine if a rat contusion model could result in a measurable deficit to both ventilatory and respiratory motor function under "normal" breathing conditions at acute to chronic stages post trauma. Through whole body plethysmography and electromyography we assessed respiratory output from three days to twelve weeks after a cervical level 3 (C3) contusion...
April 10, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29652636/hif1-mediates-a-switch-in-pyruvate-kinase-isoforms-after-myocardial-infarction
#5
Allison Lesher Williams, Vedbar Khadka, Mingxin Tang, Abigail Avelar, Kathryn J Schunke, Mark Menor, Ralph Victor Shohet
Alternative splicing of RNA is an underexplored area of transcriptional response. We expect that early changes in alternatively spliced genes may be important for responses to cardiac injury. Hypoxia inducible factor 1 (HIF1) is a key transcription factor that rapidly responds to loss of oxygen through alteration of metabolism and angiogenesis. The goal of this study was to investigate the transcriptional response after myocardial infarction (MI) and to identify novel, hypoxia-driven changes, including alternative splicing...
April 13, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29652595/stem-cells-for-skeletal-muscle-tissue-engineering
#6
Molly N Pantellic, Lisa Marie Larkin
Volumetric muscle loss (VML) is a debilitating condition wherein muscle loss overwhelms the body's normal physiological repair mechanism. VML is particularly common among military service members who have sustained war injuries. Because of the high social and medical cost associated with VML and suboptimal current surgical treatments, there is great interest in developing better VML therapies. Skeletal muscle tissue engineering (SMTE) is a promising alternative to traditional VML surgical treatments that use autogenic tissue grafts, and rather uses isolated stem cells with myogenic potential to generate de novo skeletal muscle tissues to treat VML...
March 14, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29651902/shoulder-and-lower-back-joint-reaction-forces-in-seated-double-poling
#7
Marie Lund Ohlsson, Jonas Danvind, L Joakim Holmberg
Overuse injuries in the shoulders and lower back are hypothesized to be common in cross-country sit-skiing. Athletes with reduced trunk muscle control mainly sits with their knees higher than hips (KH). To reduce spinal flexion, a position with the knees below the hips (KL) was enabled for these athletes using a frontal trunk support. The aim of the study was to compare the shoulder joint (glenohumeral joint) and L4-L5 joint reactions between the sitting positions KL and KH. Five able-bodied female athletes performed submaximal and maximal exercise tests in the sitting positions KL and KH on a ski-ergometer...
April 13, 2018: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/29651894/roller-massage-a-descriptive-survey-of-allied-health-professionals
#8
Scott W Cheatham
BACKGROUND: In sports medicine, the interprofessional care of athletes has become a frequent practice. This type of care often involves different interventions used among professionals. One common intervention prescribed is roller massage (RM) or self-myofascial release. The trends in the use of RM among allied health professionals is non-existent. The surveillance of such responses has not been documented. PURPOSE: To survey and document responses in the knowledge, clinical application, and use of RM devices among allied health professionals in the United States...
April 13, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29651864/exogenous-skeletal-muscle-satellite-cells-promote-the-repair-of-levator-palpebrae-superioris-mechanical-damage-in-rat
#9
Lin Ye, Yuanyuan Yao, Hui Guo, Yun Peng
AIM OF THE STUDY: Blepharoptosis is a drooping of the upper eyelid, usually due to dysfunction of the levator palpebrae superioris (LPS). Recently, skeletal muscle satellite cells (SSCs) have been reported to promote the repair of damaged skeletal muscle. This study aims to investigate the potential contribution of exogenous SSCs to the regeneration of mechanically damaged LPS. MATERIALS AND METHODS: Thirty-two rats were randomly divided into four groups, including control group, SSCs-treated group, SSCs-treated injury group and non-treated injury group...
April 13, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29651514/perspectives-in-football-medicine
#10
REVIEW
M Waldén, M Hägglund, H Bengtsson, J Ekstrand
The high injury rate among men's professional football players is well-known. Therefore, the Union of European Football Associations (UEFA) launched an injury study already in 2001. This study, the UEFA Elite Club Injury Study (ECIS), currently includes data from a total of 51 clubs from 18 European countries with more than 14,000 registered injuries. With the 21st  World Cup (WC) in Russia just around the corner, we have from our study identified a higher match injury rate and a higher proportion of severe injuries in the European Championships compared to the preceding club competitive seasons...
April 12, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29651387/synchronous-soleus-and-reverse-sural-flap-for-large-soft-tissue-defect-reconstruction-of-leg
#11
Seyed Esmail Hassanpour, Masoud Yavari, Amir Reza Motabar
BACKGROUND: Extended Soft tissue defect of leg including middle and distal parts always has been a challenge for many plastic surgeons and also a frustrated problem for patients and families. To introduce the use of the soleus muscle and reverse sural flaps as synchronous surgical treatment alternative of the leg bone exposure with large soft tissue defect, this study was conducted. METHODS: The medical records of patients undergoing transposition of the soleus muscle for treating exposed bone in the leg and simultaneous sural flap were retrospectively analyzed from January 2009 to July 2014, while gathering information on the used muscle was to cover the lesion...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29650376/trapezius-muscle-transfer-for-restoration-of-elbow-extension-in-a-traumatic-brachial-plexus-injury
#12
Hamza M Alrabai, Martin G Gesheff, Ahmed I Hammouda, Janet D Conway
Voluntary elbow extension is essential for optimal upper limb positioning required for daily living activities, particularly above-shoulder maneuvers. The authors present a case of traumatic brachial plexus injury in which paralysis of the musculature selectively supplied by the posterior cord was based on magnetic resonance imaging and nerve conduction studies. An attempt at a radial nerve graft at another center was not effective. Ipsilateral hand function improved after multiple local tendon transfers were performed...
April 9, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29650223/surgeons-muscle-load-during-robotic-assisted-laparoscopy-performed-with-a-regular-office-chair-and-the-preferred-of-two-ergonomic-chairs-a-pilot-study
#13
T Dalager, P T Jensen, T S Winther, T R Savarimuthu, A Markauskas, O Mogensen, K Søgaard
Surgeons work in awkward work postures and have high precision demands - well-known risk factors for musculoskeletal pain. Robotic-assisted laparoscopy is expected to be less demanding compared to conventional laparoscopy; however, studies indicate that robotic-assisted laparoscopy is also associated with poor ergonomics and musculoskeletal pain. The ergonomic condition in the robotic console is partially dependent upon the chair provided, which often is a regular office chair. Our study quantified and compared the muscular load during robotic-assisted laparoscopy using one of two custom built ergonomic chairs and a regular office chair...
April 9, 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29649092/ascorbic-acid-attenuates-multifidus-muscles-injury-and-atrophy-after-posterior-lumbar-spine-surgery-by-suppressing-inflammation-and-oxidative-stress-in-a-rat-model
#14
Pan Tang, Yu Gu, Jia-Ming Gu, Zi-Ang Xie, Jia-Qi Xu, Xiang-De Zhao, Kang-Mao Huang, Ji-Ying Wang, Xue-Sheng Jiang, Shun-Wu Fan, Zhi-Jun Hu
STUDY DESIGN: A rat model of multifidus muscles injury and atrophy after posterior lumbar spine surgery. OBJECTIVE: We determined the effect of ascorbic acid (AA) on the postoperative multifidus muscles in rat model. SUMMARY OF BACKGROUND DATA: Previous studies show oxidative stress and inflammation are two main molecular mechanisms in multifidus muscle injury and atrophy after posterior lumbar surgery. AA may have a protective effect in postoperative multifidus muscles...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29649068/is-exercise-the-right-medicine-for-dystrophic-muscle
#15
Hannah R Spaulding, Joshua T Selsby
INTRODUCTION: Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by a dystrophin protein deficiency. Dystrophin functions to stabilize and protect the muscle fiber during muscle contraction, thus the absence of functional dystrophin protein leads to muscle injury. DMD patients experience progressive muscle necrosis, loss of function, and ultimately succumb to respiratory failure or cardiomyopathy. Exercise is known to improve muscle health and strength in healthy individuals as well as positively impact other systems...
April 11, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29648982/effects-of-mitochondrial-transplantation-on-bioenergetics-cellular-incorporation-and-functional-recovery-after-spinal-cord-injury
#16
Jenna L Gollihue, Samir P Patel, Khalid C Eldahan, David H Cox, Renee R Donahue, Brad Taylor, Pat Sulllivan, Alexander G Rabchevsky
Our previous studies reported that pharmacological maintenance of mitochondrial bioenergetics after experimental spinal cord injury (SCI) provided functional neuroprotection. Recent evidence indicates that endogenous mitochondrial transfer is neuroprotective as well, and so we extended these studies with a novel approach to transplant exogenous mitochondria into the injured rat spinal cord. Using a rat model of L1/L2 contusion SCI, we herein report that transplantation of exogenous mitochondria derived from either cell culture or syngeneic leg muscle maintain acute bioenergetics of the injured spinal cord in a concentration-dependent manner...
March 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29648951/design-of-a-lightweight-soft-robotic-arm-using-pneumatic-artificial-muscles-and-inflatable-sleeves
#17
Preston Ohta, Luis Valle, Jonathan King, Kevin Low, Jaehyun Yi, Christopher G Atkeson, Yong-Lae Park
As robots begin to interact with humans and operate in human environments, safety becomes a major concern. Conventional robots, although reliable and consistent, can cause injury to anyone within its range of motion. Soft robotics, wherein systems are made to be soft and mechanically compliant, are thus a promising alternative due to their lightweight nature and ability to cushion impacts, but current designs often sacrifice accuracy and usefulness for safety. We, therefore, have developed a bioinspired robotic arm combining elements of rigid and soft robotics such that it exhibits the positive qualities of both, namely compliance and accuracy, while maintaining a low weight...
April 2018: Soft Robotics
https://www.readbyqxmd.com/read/29644315/limb-salvage-and-reconstruction-following-a-zebra-attack
#18
Jacob T Carlson, James C Yuen, Matthew R Smeds
Animal bites are fairly rare events but can cause devastating traumatic injuries to the victim. In addition to the soft tissue, vascular, and orthopedic trauma inflicted by these occurrences, bite injuries also have the potential to introduce an inoculum of microbes, which may progress to an infection if not treated properly and expeditiously. We present the case of a healthy male who sustained multiple bite wounds from a domestic zebra to his left upper extremity. This attack caused severe damage, including devascularization of the arm at the brachial artery, disruption of the distal biceps and brachialis, stripping of the forearm nerves, and shearing of the overlying soft tissue...
June 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29644278/fabella-fracture-with-radiological-imaging-a-case-report
#19
Feng Zhou, Fei Zhang, Guoying Deng, Chun Bi, Jiandong Wang, Qian Wang, Qiugen Wang
The fabella is a kind of sesamoid bone which is located in the lateral head of the gastrocnemius muscle. A slice of studies demonstrated that fabella is involved in the knee joint stabilization. Fabella fracture may cause knee pain or functional impairment as the previous reports pointed. It is extremely rare, which leads to its high rate of missed diagnosis in clinical and radiography to some extent. We report a case of a 38-year-old female who was struck by an electromobile. The fabella fracture was confirmed on X-ray plain films...
December 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29644156/group-a-streptococcal-pyomyositis-in-a-previously-healthy-six-year-old-girl
#20
Daniel Tawfik, Wendy L Hobson
A six-year-old previously healthy girl was seen in an outpatient pediatric clinic in the western United States for thigh pain. The pain was accompanied by an initial fever and was most severe after periods of prolonged rest. During the evaluation, her exam rapidly progressed with severe episodic pain and tenderness of the right anteromedial thigh. Magnetic resonance imaging (MRI) demonstrated signal enhancement at the insertion of the right obturator externus muscle. Blood culture was positive for Group A Streptococcus...
February 8, 2018: Curēus
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