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Muscle injury

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https://www.readbyqxmd.com/read/28103314/expression-of-a-mutant-sema3a-protein-with-diminished-signalling-capacity-does-not-alter-als-related-motor-decline-or-confer-changes-in-nmj-plasticity-after-botoxa-induced-paralysis-of-male-gastrocnemic-muscle
#1
Elizabeth B Moloney, Barbara Hobo, Fred De Winter, Joost Verhaagen
Terminal Schwann cells (TSCs) are specialized cells that envelop the motor nerve terminal, and play a role in the maintenance and regeneration of neuromuscular junctions (NMJs). The chemorepulsive protein semaphorin 3A (SEMA3A) is selectively up-regulated in TSCs on fast-fatigable muscle fibers following experimental denervation of the muscle (BotoxA-induced paralysis or crush injury to the sciatic nerve) or in the motor neuron disease amyotrophic lateral sclerosis (ALS). Re-expression of SEMA3A in this subset of TSCs is thought to play a role in the selective plasticity of nerve terminals as observed in ALS and following BotoxA-induced paralysis...
2017: PloS One
https://www.readbyqxmd.com/read/28103292/muscle-reactive-oxygen-species-ros-contribute-to-post-incisional-guarding-via-the-trpa1-receptor
#2
Daisuke Sugiyama, Sinyoung Kang, Timothy J Brennan
BACKGROUND: Deep tissues and their afferents have unique responses to various stimuli and respond to injury distinctively. However, the types of receptors and endogenous ligands that have a key role in pain after deep tissue incision are unknown. TRPA1 has been shown to mediate pain-related responses in inflammation- and nerve injury-induced pain models. We hypothesized that TRPA1 has an important role in pain behaviors after deep tissue incision. METHODS: The effect of various doses of intraperitoneal (i...
2017: PloS One
https://www.readbyqxmd.com/read/28102732/exacerbating-effects-of-pm2-5-in-ova-sensitized-and-challenged-mice-and-the-expression-of-trpa1-and-trpv1-protein-in-lung
#3
Hong Liu, Xinsheng Fan, Naiqian Wang, Yuyan Zhang, Jinghua Yu
OBJECTIVE: To investigate the effects of PM2.5 on asthma-related phenotypes and on the expression of TRPA1, V1 protein in lung in a mouse model of asthma. METHODS: Female Balb/c mice were utilized to establish 28 and 42 day asthma models. Mice were sensitized with OVA and challenged with OVA, OVA plus normal saline (NS), or OVA plus PM2.5 at two doses, 1.6 mg·kg(-1) or 8.0 mg·kg(-1). PM2.5 was administrated by intratracheal instillationwithout anesthesia. 24 hours after the final OVA challenge changes in airway resistance (RI) and lung compliance (Cdyn) in response to acetylcholine chloride (ACH) were evaluated, and blood, bronchoalveolar lavage fluid (BALF) and lung tissue samples were taken...
January 19, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28102155/surgical-treatment-of-radial-head-fractures-outcomes-and-complications
#4
Bartosz Chwedczuk, Piotr Piekarczyk, Krzysztof Kwiatkowski, Krzysztof Piątkowski
BACKGROUND: Appropriate treatment of radial head fractures remains an area of disputes and controversy. The present paper aims to assess the outcomes of surgical fixation of these injuries and identify the most common complications. MATERIAL AND METHODS: The medical records of 63 patients (25 women and 38 men) treated in 2011 -2014 were analysed retrospectively. The treatment outcomes were assessed according to the Broberg and Morrey rating system and the QuickDASH score...
October 28, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28102011/local-myogenic-pulp-derived-cell-injection-enhances-craniofacial-muscle-regeneration-in-vivo
#5
J E Jung, M J Song, S Shin, Y J Choi, K H Kim, C J Chung
OBJECTIVES: To enhance myogenic differentiation in pulp cells isolated from extracted premolars by epigenetic modification using a DNA demethylation agent, 5-aza-2'-deoxycytidine (5-Aza), and to evaluate the potent stimulatory effect of 5-Aza-treated pulp cell injection for craniofacial muscle regeneration in vivo. SETTING AND SAMPLE POPULATION: Pulp cells were isolated from premolars extracted for orthodontic purposes from four adults (age range, 18-22.1 years)...
February 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28101909/efficient-transdifferentiation-of-human-dermal-fibroblasts-into-skeletal-muscle
#6
Selwa Mokhtar Boularaoui, Khaled M A Abdel-Raouf, Noaf Salah Ali Alwahab, Megan E Kondash, George A Truskey, Jeremy Choon Meng Teo, Nicolas Christoforou
Skeletal muscle holds significant regenerative potential but is incapable of restoring tissue loss caused due to severe injury, congenital defects, or tumor ablation. Consequently, skeletal muscle models are being developed to study human pathophysiology and regeneration. Their physiological accuracy, however, is hampered by the lack of an easily accessible human cell source that is readily expandable and capable of efficient differentiation. MYOD1, a master gene regulator, induces transdifferentiation of a variety of cell types into skeletal muscle, although inefficiently in human cells...
January 18, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28101559/cannabis-use-in-persons-with-traumatic-spinal-cord-injury-in-denmark
#7
Sven R Andresen, Fin Biering-Sørensen, Ellen Merete Hagen, Jørgen F Nielsen, Flemming W Bach, Nanna B Finnerup
OBJECTIVE: To evaluate recreational and medical cannabis use in individuals with traumatic spinal cord injury, including reasons and predictors for use, perceived benefits and negative consequences. DESIGN: Cross-sectional survey in Denmark. METHODS: A 35-item questionnaire was sent to 1,101 patients with spinal cord injury who had been in contact with a rehabilitation centre between 1990 and 2012. RESULTS: A total of 537 participants completed the questionnaire...
January 18, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28101364/hemodynamic-effects-of-electrical-muscle-stimulation-in-the-prophylaxis-of-deep-vein-thrombosis-for-intensive-care-unit-patients-a-randomized-trial
#8
Masahiro Ojima, Ryosuke Takegawa, Tomoya Hirose, Mitsuo Ohnishi, Tadahiko Shiozaki, Takeshi Shimazu
BACKGROUND: Deep vein thrombosis (DVT) is a major complication in critical care. There are various methods of prophylaxis, but none of them fully prevent DVT, and each method has adverse effects. Electrical muscle stimulation (EMS) could be a new effective approach to prevent DVT in intensive care unit (ICU) patients. We hypothesized that EMS increases the venous flow of the lower limbs and has a prophylactic effect against the formation of DVT. METHODS: This study included 26 patients admitted to a single ICU...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28100269/a-spleen-tyrosine-kinase-inhibitor-attenuates-the-proliferation-and-migration-of-vascular-smooth-muscle-cells
#9
Hyang-Hee Seo, Sang Woo Kim, Chang Youn Lee, Kyu Hee Lim, Jiyun Lee, Eunhyun Choi, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang
BACKGROUND: Pathologic vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury promotes the development of occlusive vascular disease. Therefore, an effective chemical agent to suppress aberrant proliferation and migration of VSMCs can be a potential therapeutic modality for occlusive vascular disease such as atherosclerosis and restenosis. To find an anti-proliferative chemical agent for VSMCs, we screened an in-house small molecule library, and the selected small molecule was further validated for its anti-proliferative effect on VSMCs using multiple approaches, such as cell proliferation assays, wound healing assays, transwell migration assays, and ex vivo aortic ring assay...
January 18, 2017: Biological Research
https://www.readbyqxmd.com/read/28100124/compelling-overuse-injury-incidence-in-youth-multisport-athletes
#10
Abdallah Rejeb, Amanda Johnson, Roel Vaeyens, Cosmin Horobeanu, Abdulaziz Farooq, Erik Witvrouw
The present investigation was carried out to examine the incidence and pattern of injuries in adolescent multisport athletes from youth sports academy. Injury data were prospectively collected from 166 athletes during the seasons from 2009 to 2014. A total of 643 injuries were identified, 559 (87.0%) were time-loss injuries. The overall injury incidence was 5.5 (95% confidence interval CI: 5.1-6.0), the incidence of time-loss injuries was 4.8 (95% CI: 4.4-5.2), the incidence of growth conditions was 1.2 (95% CI: 1...
January 18, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28099528/inos-as-a-driver-of-inflammation-and-apoptosis-in-mouse-skeletal-muscle-after-burn-injury-possible-involvement-of-sirt1-s-nitrosylation-mediated-acetylation-of-p65-nf-%C3%AE%C2%BAb-and-p53
#11
Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J A Jeevendra Martyn, Ronald G Tompkins, Kentaro Shimokado, Masao Kaneki
Inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, and play a pivotal role in insulin resistance and muscle wasting. We and others have shown that inducible nitric oxide synthase (iNOS), a major mediator of inflammation, plays an important role in stress (e.g., burn)-induced insulin resistance. However, it remains to be determined how iNOS induces insulin resistance. Moreover, the interrelation between inflammatory response and apoptosis is poorly understood, although they often develop simultaneously...
2017: PloS One
https://www.readbyqxmd.com/read/28099237/lower-limb-muscular-strength-balance-and-mobility-levels-in-adults-following-severe-thermal-burn-injuries
#12
Mohammed T A Omar, Amal M Abd El Baky, Anwar A Ebid
Severe burn injuries are associated with hypermetabolic response and increased catabolism. These lead to a vast loss of muscle mass and reduced muscle strength and function. Therefore, the aim of this study is to determine the impact of severe burn injuries on lower-limb muscular strength, balance, and mobility level in adults. Forty burned adults with burned TBSA (burned TBSA) ≥40% participated in this study. The peak torque and total work of quadriceps and knee flexors were calculated at 150°/sec using Biodex isokinetic dynamometer...
January 10, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28095141/an-old-problem-aging-and-skeletal-muscle-strain-injury
#13
Brent A Baker
: Clinical Scenario: Even though chronological aging is an inevitable phenomenological consequence occurring in every living organism, it is biological aging that may be the most significant factor challenging our quality of life. Development of functional limitations, resulting from improper maintenance and restoration of various organ systems, ultimately leads to reduced health and independence. Skeletal muscle is an organ system, that when challenged, is often injured in response to varying stimuli...
January 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28095094/female-age-related-differences-in-biomechanics-and-muscle-activity-during-descents-on-the-outstretched-arms
#14
Lauren Jane Lattimer, Joel Lanovaz, Jon Farthing, Stéphanie Madill, Soo Kim, Stephen Robinovitch, Cathy Arnold
The purposes of this study were to examine female age differences in: 1) upper extremity (UE) and trunk muscle activity, elbow joint moment, loading force and UE energy absorption during a controlled forward body descent and 2) UE muscle strength. Twenty young (mean 24.8±3.4 yrs.) and 20 older (68.4±5.7 yrs.) women were assessed via dynamometry for isometric, concentric and eccentric UE strength and performed forward descents on force plates at three body lean angles (60, 45, and 30° from horizontal). Significant differences (p < ...
January 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28094257/pten-is-necessary-for-the-quiescence-and-maintenance-of-adult-muscle-stem-cells
#15
Feng Yue, Pengpeng Bi, Chao Wang, Tizhong Shan, Yaohui Nie, Timothy L Ratliff, Timothy P Gavin, Shihuan Kuang
Satellite cells (SCs) are myogenic stem cells required for regeneration of adult skeletal muscles. A proper balance among quiescence, activation and differentiation is essential for long-term maintenance of SCs and their regenerative function. Here we show a function of Pten (phosphatase and tensin homologue) in quiescent SCs. Deletion of Pten in quiescent SCs leads to their spontaneous activation and premature differentiation without proliferation, resulting in depletion of SC pool and regenerative failure...
January 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28094213/examination-of-the-early-wound-healing-process-under-different-wound-dressing-conditions
#16
Toshiro Kibe, Takashi Koga, Kazuhide Nishihara, Takao Fuchigami, Takuya Yoshimura, Tetsushi Taguchi, Norifumi Nakamura
OBJECTIVE: Various types of wound-healing dressings have been used to assist in the healing of surgical wounds. We analyzed the wound-healing process in an animal model using different existing wound dressings. STUDY DESIGN: Full-thickness defects were created using a biopsy punch on the backs of 7-week-old rats. The wounded areas were covered with NEOVEIL (polyglycolic acid [PGA]) or TERUDERMIS (collagen sponge [CS]) affixed using a rat jacket. The wound area, neo-epithelium length, and α-smooth muscle actin (α-SMA) expression were evaluated and compared among the control, PGA, and CS groups...
November 11, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28093618/mri-assessment-of-calf-injuries-in-australian-football-league-players-findings-that-influence-return-to-play
#17
George Waterworth, Sara Wein, Alexandra Gorelik, Andrew H Rotstein
OBJECTIVE: Calf muscle strains have become increasingly prevalent in recent seasons of the Australian Football League (AFL) and represent a significant cause of time lost from competition. The purpose of this study was to examine the association between MRI features of calf muscle strains and games missed and to thereby identify parameters that are of prognostic value. MATERIALS AND METHODS: A retrospective analysis of MRI scans of AFL players with calf strains referred to a musculoskeletal radiology clinic over a 5-year period (2008-2012) was performed...
January 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28093018/algorithm-for-bionic-hand-reconstruction-in-patients-with-global-brachial-plexopathies
#18
Laura A Hruby, Agnes Sturma, Johannes A Mayer, Anna Pittermann, Stefan Salminger, Oskar C Aszmann
OBJECTIVE Global brachial plexus lesions with multiple root avulsions are among the most severe nerve injuries, leading to lifelong disability. Fortunately, in most cases primary and secondary reconstructions provide a stable shoulder and restore sufficient arm function. Restoration of biological hand function, however, remains a reconstructive goal that is difficult to reach. The recently introduced concept of bionic reconstruction overcomes biological limitations of classic reconstructive surgery to restore hand function by combining selective nerve and muscle transfers with elective amputation of the functionless hand and its replacement with a prosthetic device...
January 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28092739/an-emg-driven-biomechanical-model-of-the-canine-cervical-spine
#19
M Alizadeh, G G Knapik, J S Dufour, C Zindl, M J Allen, J Bertran, N Fitzpatrick, W S Marras
Due to the frequency of cervical spine injuries in canines, the purpose of this effort was to develop an EMG-driven dynamic model of the canine cervical spine to assess a biomechanical understanding that enables one to investigate the risk of neck disorders. A canine subject was recruited in this investigation in order to collect subject specific data. Reflective markers and a motion capture system were used for kinematic measurement; surface electrodes were used to record electromyography signals, and with the aid of force plate kinetics were recorded...
December 26, 2016: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28092265/the-fibronectin-synergy-site-re-enforces-cell-adhesion-and-mediates-a-crosstalk-between-integrin-classes
#20
Maria Benito-Jardón, Sarah Klapproth, Irene Gimeno-LLuch, Tobias Petzold, Mitasha Bharadwaj, Daniel J Müller, Gabriele Zuchtriegel, Christoph A Reichel, Mercedes Costell
Fibronectin (FN), a major extracellular matrix component, enables integrin-mediated cell adhesion via binding of α5β1, αIIbβ3 and αv-class integrins to an RGD-motif. An additional linkage for α5 and αIIb is the synergy site located in close proximity to the RGD motif. We report that mice with a dysfunctional FN-synergy motif (FNsyn/syn) suffer from surprisingly mild platelet adhesion and bleeding defects due to delayed thrombus formation after vessel injury. Additional loss of β3 integrins dramatically aggravates the bleedings and severely compromises smooth muscle cell coverage of the vasculature leading to embryonic lethality...
January 16, 2017: ELife
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