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https://www.readbyqxmd.com/read/29053988/intermedin-reduces-neointima-formation-by-regulating-vascular-smooth-muscle-cell-phenotype-via-camp-pka-pathway
#1
Qing Zhu, Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Jin-Ling Ren, Di Wu, Yao Chen, Lin-Shuang Zhang, Yan-Rong Yu, Chao-Shu Tang, Yong-Fen Qi
BACKGROUND AND AIMS: Vascular smooth muscle cell (VSMC) dedifferentiation contributes to neointima formation, which results in various vascular disorders. Intermedin (IMD), a cardiovascular paracrine/autocrine polypeptide, is involved in maintaining circulatory homeostasis. However, whether IMD protects against neointima formation remains largely unknown. The purpose of this study is to investigate the role of IMD in neointima formation and the possible mechanism. METHODS: IMD1-53 (100ng/kg/h) or saline water was used on rat carotid-artery balloon-injury model...
October 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29053875/current-state-of-the-surgical-treatment-of-terminal-neuromas
#2
Graham C Ives, Theodore A Kung, Bao Tram Nghiem, Daniel C Ursu, David L Brown, Paul S Cederna, Stephen W P Kemp
Painful terminal neuromas resulting from nerve injury following amputation are common. However, there is currently no universally accepted gold standard of treatment for this condition. A comprehensive literature review is presented on the treatment of terminal neuromas. Four categories of terminal neuroma surgical procedures are assessed: epineurial closure; nerve transposition with implantation; neurorrhaphy, and alternate target reinnervation. Significant patient and case studies are highlighted in each section, focusing on surgical technique and patient outcome metrics...
October 19, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29052828/long-term-results-of-primary-repair-of-combined-cuts-on-the-median-and-ulnar-nerves-in-the-forearm
#3
Kemal Özaksar, Hüseyin Günay, Levent Küçük, Erhan Coşkunol
BACKGROUND: The objective of this clinical study was to evaluate sensory and motor functions in the later period following primary repair of combined injuries of the ulnar and median nerves in the forearm at proximal, middle, and distal levels. METHODS: Later period sensory evaluation of ulnar and median combined cuts was performed using two-point discrimination and monofilament tests. On the other hand, motor evaluation was performed by determining dorsal palmar interosseus strength for the ulnar nerve and abductor pollicis brevis muscle strength for the median nerve...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29052519/circuit-training-enhances-function-in-patients-undergoing-total-knee-arthroplasty-a-retrospective-cohort-study
#4
Wei-Hsiu Hsu, Wei-Bin Hsu, Wun-Jer Shen, Zin-Rong Lin, Shr-Hsin Chang, Robert Wen-Wei Hsu
BACKGROUND: The number of patients receiving total knee arthroplasty (TKA) has been rising every year due to the aging population and the obesity epidemic. Post-operative rehabilitation is important for the outcome of TKA. METHODS: A series of 34 patients who underwent primary unilateral TKA was retrospectively collected and divided into either exercise group (n = 16) and control group (n = 18). The exercise group underwent a 24-week course of circuit training beginning 3 months after total knee arthroplasty (TKA)...
October 19, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29051185/cgmp-elevating-compounds-and-ischemic-conditioning-provide-cardioprotection-against-ischemia-and-reperfusion-injury-via-cardiomyocyte-specific-bk-channels
#5
Sandra Frankenreiter, Piotr Bednarczyk, Angelina Kniess, Nadja Bork, Julia Straubinger, Piotr Koprowski, Antoni Wrzosek, Eva Mohr, Angela Logan, Michael P Murphy, Meinrad Gawaz, Thomas Krieg, Adam Szewczyk, Viacheslav O Nikolaev, Peter Ruth, Robert Lukowski
Background -The nitric oxide-sensitive guanylyl cyclase (NO-GC)/cyclic guanosine-3',5'-monophosphate (cGMP)/cGMP-dependent protein kinase type I (cGKI)-signaling pathway can afford protection against the ischemia and reperfusion (I/R) injury that occurs during myocardial infarction (MI). Reportedly, voltage and Ca(2+)-activated K(+) channels of the BK-type are stimulated by cGMP/cGKI and recent ex-vivo studies implicated that increased BK activity favors the survival of the myocardium at I/R. It remains unclear, however, whether the molecular events downstream of cGMP involve BK channels present in cardiomyocytes (CMs) or in other cardiac cell types...
October 19, 2017: Circulation
https://www.readbyqxmd.com/read/29051167/hamstring-muscle-injuries-in-elite-football-translating-research-into-practice
#6
EDITORIAL
Matthew Buckthorpe, Mo Gimpel, Steve Wright, Thomas Sturdy, Matthew Stride
No abstract text is available yet for this article.
October 19, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29051088/update-on-the-role-of-pentraxin-3-in-atherosclerosis-and-cardiovascular-diseases
#7
REVIEW
Matteo Casula, Fabrizio Montecucco, Aldo Bonaventura, Luca Liberale, Alessandra Vecchié, Franco Dallegri, Federico Carbone
Pentraxin 3 (PTX3) is an acute-phase protein that was recently demonstrated to play pleiotropic activities in cardiovascular (CV) diseases. Tumor necrosis factor and interleukins up-regulates PTX3 transcription in different cell types (i.e. endothelial cells, phagocytes, smooth muscle cells, fibroblasts and glial cells) involved in atherogenesis. By interacting with numerous ligands, PTX3 acts as a modulatory molecule of complement system, inflammatory response, angiogenesis, and vascular/tissue remodeling...
October 16, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29051005/protective-effect-of-a-rho-kinase-inhibitor-on-bladder-dysfunction-in-a-rat-model-of-chronic-bladder-ischemia
#8
Hidenori Akaihata, Masanori Nomiya, Kanako Matsuoka, Tomoyuki Koguchi, Junya Hata, Nobuhiro Haga, Nobuhiro Kushida, Kei Ishibashi, Ken Aikawa, Yoshiyuki Kojima
OBJECTIVES: To investigate the effect of fasudil, a Rho-kinase inhibitor, on chronic ischemia-related bladder dysfunction. METHODS: Male Sprague-Dawley rats (16 weeks old) were divided into control, chronic bladder ischemia (CBI) and CBI with fasudil treatment (CBI/Fa) groups. The CBI and CBI/Fa groups underwent balloon endothelial injury of bilateral iliac arteries and received a 2% cholesterol diet for 8 weeks after the procedure to induce chronic bladder ischemia...
October 16, 2017: Urology
https://www.readbyqxmd.com/read/29051003/spontaneous-regeneration-of-nerve-fiber-and-irreversibility-of-corporal-smooth-muscle-fibrosis-after-cavernous-nerve-crush-injury-evidence-from-serial-transmission-electron-microscopy-and-intracavernous-pressure
#9
Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao, Han-Sun Chiang
OBJECTIVES: To determine the pathophysiological progresses following bilateral cavernous nerve crushing (BCNC) injury, as an index for a treatment point and establishment of adequate treatment strategies for neurogenic erectile dysfunction (ED). METHODS: Thirty-six rats were assigned to 1 of 6 groups, and BCNC or sham surgery was performed. Functional testing and ultrastructural analyses were performed immediately and at 7, 14, 21, and 28 d after the cavernous nerve (CN) injury (n = 6)...
October 16, 2017: Urology
https://www.readbyqxmd.com/read/29050687/comparison-of-adverse-events-and-postoperative-mobilization-following-knee-extensor-mechanism-rupture-repair-a-systematic-review-and-network-meta-analysis
#10
Joseph Serino, Amin Mohamadi, Sebastian Orman, Brian McCormick, Philip Hanna, Michael J Weaver, Mitchel B Harris, Ara Nazarian, Arvind von Keudell
BACKGROUND: Extensor mechanism rupture (EMR) of the knee is a rare but potentially debilitating injury that often occurs due to trauma. While a wide variety of surgical treatments have been reported, there is currently no consensus on the most successful treatment method. The timing of post-operative joint mobilization is also critical for successful recovery after EMR repair. Despite the traditional method of complete immobilization for 6 weeks, there is an increasing trend towards early post-operative knee mobilization...
October 16, 2017: Injury
https://www.readbyqxmd.com/read/29050211/silibinin-attenuates-radiation-induced-intestinal-fibrosis-and-reverses-epithelial-to-mesenchymal-transition
#11
Joong Sun Kim, Na-Kyung Han, Sung-Ho Kim, Hae-June Lee
Radiotherapy is a common treatment for cancer patients, but its use is often restricted by the tolerance of normal tissue. As cancer patients live longer, delayed radiation effects on normal tissue have become a concern. Radiation-induced enteropathy, including inflammatory bowel disease and fibrosis, are major issues for long-term cancer survivors. To investigate whether silibinin attenuates delayed radiation-induced intestinal injury in mice, we focused on intestinal fibrotic changes. Silibinin improved delayed radiation injuries in mice in association with decreased collagen deposition within the intestines and deceased transforming growth factor (TGF)-β1 levels in the intestine and plasma...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049990/inhibition-of-pten-activity-aggravates-post-renal-fibrosis-in-mice-with-ischemia-reperfusion-induced-acute-kidney-injury
#12
Jun Zhou, Jiying Zhong, Sen Lin, Zhenxing Huang, Hongtao Chen, Simin Tang, Chengxiang Yang, Youling Fan
BACKGROUND: Renal fibrosis is a common pathophysiological feature of chronic kidney disease. Acute kidney injury (AKI) is defined as an independent causal factor of chronic kidney disease, with a pathological representation of post renal fibrosis. However, the etiopathogenesis underlying post renal fibrosis induced by AKI is not completely understood. METHODS: BALB/c mice were treated with bpv or vehicle controls and were, respectively, the ischemia reperfusion (IR) model group and control group...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29048929/the-effect-of-hamstring-tendon-autograft-harvest-on-the-restoration-of-knee-stability-in-the-setting-of-concurrent-anterior-cruciate-ligament-and-medial-collateral-ligament-injuries
#13
Thomas J Kremen, Landon S Polakof, Sean S Rajaee, Trevor J Nelson, Melodie F Metzger
BACKGROUND: A hamstring autograft is commonly used in anterior cruciate ligament (ACL) reconstruction (ACLR); however, there is evidence to suggest that the tendons harvested may contribute to medial knee instability. HYPOTHESIS: We tested the hypothesis that the gracilis (G) and semitendinosus (ST) tendons significantly contribute to sagittal, coronal, and/or rotational knee stability in the setting of ACLR with a concurrent partial medial collateral ligament (MCL) injury...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29048928/epidemiology-of-shoulder-and-elbow-injuries-among-united-states-high-school-baseball-players-school-years-2005-2006-through-2014-2015
#14
Michael G Saper, Lauren A Pierpoint, Wei Liu, R Dawn Comstock, John D Polousky, James R Andrews
BACKGROUND: Shoulder and elbow injuries are common in young athletes, especially high school baseball players. Understanding the risk factors associated with baseball injuries is an essential first step in the development of injury prevention strategies. PURPOSE: To provide a comprehensive understanding of the epidemiology of shoulder and elbow injuries among high school baseball players in the United States. STUDY DESIGN: Descriptive epidemiological study...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29047406/loss-of-mkp-5-promotes-myofiber-survival-by-activating-stat3-bcl-2-signaling-during-regenerative-myogenesis
#15
Kisuk Min, Ahmed Lawan, Anton M Bennett
BACKGROUND: The mitogen-activated protein kinases (MAPKs) have been shown to be involved in regulating myofiber survival. In skeletal muscle, p38 MAPK and JNK are negatively regulated by MAPK phosphatase-5 (MKP-5). During muscle regeneration, MKP-5 is downregulated, thereby promoting p38 MAPK/JNK signaling, and subsequent repair of damaged muscle. Mice lacking MKP-5 expression exhibit enhanced regenerative myogenesis. However, the effect of MKP-5 on myofiber survival during regeneration is unclear...
October 18, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/29046079/iliac-crest-apophyseal-insufficiency-avulsion-fractures
#16
H E Matar, S Tripathi, D J Miller
Iliac crest apophyseal avulsion fractures are rare injuries caused mainly through forceful contraction of attached muscles during high level sporting activities. We present the first case of a spontaneous iliac crest apophyseal avulsion insufficiency fracture in a patient with severe atopic eczema on oral steroids and review the relevant literature.
October 19, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29043432/recent-advances-in-pharmacological-hormonal-and-nutritional-intervention-for-sarcopenia
#17
REVIEW
Kunihiro Sakuma, Akihiko Yamaguchi
Sarcopenia, the age-related loss of skeletal muscle mass, is characterized by a deterioration of muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, increased risk of fall-related injury, and often frailty. This review focuses on the recent advances of pharmacological, hormonal, and nutritional approaches for attenuating sarcopenia. The article is composed of the data reported in many basic and some clinical studies for mammalian muscles. Resistance training combined with amino acid-containing supplements is the gold standard to prevent sarcopenia...
October 18, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29043378/-neurogenic-myopathies-and-imaging-of-muscle-denervation
#18
REVIEW
M Wolf, C Wolf, M-A Weber
CLINICAL ISSUE: Neurogenic myopathies are primary diseases of the nervous system, which secondarily result in denervation of the target musculature. The spectrum of potential causes is manifold ranging from acute traumatic injuries and chronic compression to neurodegenerative, inflammatory, metabolic and neoplastic processes. STANDARD DIAGNOSTIC METHODS: The medical history, clinical neurological examination, and electrophysiological tests including electromyography and nerve conduction studies are crucial in diagnosing neuropathic myopathies...
October 17, 2017: Der Radiologe
https://www.readbyqxmd.com/read/29042968/hesperetin-alleviates-renal-interstitial-fibrosis-by-inhibiting-tubular-epithelial-mesenchymal-transition-in-vivo-and-in-vitro
#19
Hong-Wei Wang, Lei Shi, Yan-Ping Xu, Xing-Ya Qin, Qi-Zhi Wang
Hesperetin (HES) is a flavonoid that has been reported to exert protective effects against cardiac remodeling, lung fibrosis and hepatic fibrosis. However, reports on the effects and potential mechanisms of HES in renal fibrosis are limited. In the present study, a unilateral ureteric obstruction (UUO) mouse model and a transforming growth factor (TGF)-β1-activated normal rat kidney (NRK)-52E cell model were established. HES was subsequently administered to these models to evaluate its anti-fibrotic effects and potential underlying mechanisms of action...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042331/the-first-experience-of-triple-nerve-transfer-in-proximal-radial-nerve-palsy
#20
Mohammadreza Emamhadi, Sasan Andalib
BACKGROUND: Injury to distal of posterior cord of brachial plexus leads to palsy of the radial and axillary nerves. The symptoms are usually motor deficits of the deltoid muscle, triceps brachii muscle, and the extensor muscles of the wrist, thumb and fingers. Tendon transfers, nerve grafts, and nerve transfers are options of surgical treatment of proximal radial nerve palsy to restore some motor functions. Tendon transfer is painful, requires a long immobilization, and decreases donor muscle strength; nevertheless, nerve transfer produces promising outcome...
October 14, 2017: World Neurosurgery
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