Annabel Vreeker, Scott C Fears, Susan K Service, Lucia Pagani, Joseph S Takahashi, Carmen Araya, Xinia Araya, Julio Bejarano, Maria C Lopez, Gabriel Montoya, Claudia Patricia Montoya, Terri M Teshiba, Javier Escobar, Rita M Cantor, Carlos López-Jaramillo, Gabriel Macaya, Julio Molina, Victor I Reus, Chiara Sabatti, Roel A Ophoff, Nelson B Freimer, Carrie E Bearden
BACKGROUND: Disturbed sleep and activity are prominent features of bipolar disorder type I (BP-I). However, the relationship of sleep and activity characteristics to brain structure and behavior in euthymic BP-I patients and their non-BP-I relatives is unknown. Additionally, underlying genetic relationships between these traits have not been investigated. METHODS: Relationships between sleep and activity phenotypes, assessed using actigraphy, with structural neuroimaging (brain) and cognitive and temperament (behavior) phenotypes were investigated in 558 euthymic individuals from multi-generational pedigrees including at least one member with BP-I...
February 2021: Psychological Medicine