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K M Loganovsky, M V Gresko
: Objective of the study was to determine pathological changes of the personality of the clean up workers (liquida tors) of the Chornobyl accident and the participants in the anti terrorist operation (ATO) in Eastern Ukraine and radiation threat perception assessment.Design, object and methods. The cross sectional and retrospective assessments of the clean up workers of the Chornobyl accident (n = 185), evacuees from the Chornobyl Exclusion Zone (n = 112) from the randomized sample of individuals who are registered in the Clinical and epidemiological registry (CER) of the State Institution «National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine» [NRCRM] and partici pants of the ATO in Eastern Ukraine (n = 62) who underwent treatment and rehabilitation in the Department of Radiation Psychoneurology of the NRCRM Clinic have been done...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
Jan Scott, Steven Marwaha, Aswin Ratheesh, Iain Macmillan, Alison R Yung, Richard Morriss, Ian B Hickie, Andreas Bechdolf
BACKGROUND: A clinical and research challenge is to identify which depressed youth are at risk of "early transition to bipolar disorders (ET-BD)." This 2-part study (1) examines the clinical utility of previously reported BD at-risk (BAR) criteria in differentiating ET-BD cases from unipolar depression (UP) controls; and (2) estimates the Number Needed to Screen (NNS) for research and general psychiatry settings. METHODS: Fifty cases with reliably ascertained, ET-BD I and II cases were matched for gender and birth year with 50 UP controls who did not develop BD over 2 years...
November 21, 2016: Schizophrenia Bulletin
Cornelia Rada, Alexandru Teodor Ispas
BACKGROUND: Alcohol consumption (AC) has negative social and economic consequences, affects health, and can create dependence. As dependence is particularly difficult to cure, prevention is important. This study aimed to identify the frequency, quantity, occasions, reasons, type of AC, and correlation with accentuated personality traits among young adults in Romania. METHODS: Participants were 1359 young adults aged 18-30 years (average age, 22.67 years; standard deviation [SD], 3...
October 27, 2016: Substance Abuse Treatment, Prevention, and Policy
Erika F H Saunders, Christopher E Ramsden, Mostafa S Sherazy, Alan J Gelenberg, John M Davis, Stanley I Rapoport
OBJECTIVE: There is growing evidence that inflammation is an important mediator of pathophysiology in bipolar disorder. The omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) metabolic pathways participate in several inflammatory processes and have been linked through epidemiologic and clinical studies to bipolar disorder and its response to treatment. We review the data on PUFAs as biomarkers in bipolar disorder and n-3 PUFA used as treatment for bipolar disorder. DATA SOURCES: PubMed and CINAHL were searched for articles on PUFA and bipolar disorder published in the English language through November 6, 2013, with an updated search conducted on August 20, 2015...
October 2016: Journal of Clinical Psychiatry
Giulio Perugi, Elie Hantouche, Giulia Vannucchi
Contrary to DSM-5 definition, based on the recurrence of hypomanic and depressive symptoms for a period of 2 years, cyclothymia is better defined in a neurodevelopmental perspective as a pathological variant of cyclothymic temperament. Emotional dysregulation with extreme mood instability and reactivity are the core features of the complex symptomatology. Available epidemiological and clinical data showed the frequent association of cyclothymia with anxiety, impulse control, substance use and cluster B and C personality disorders, suggesting a high prevalence in clinical samples and supporting its validity as a distinct form of bipolarity...
June 16, 2016: Current Neuropharmacology
Maurizio Pompili, Marco Innamorati, Mariantonietta Milelli, Michele Battuello, Denise Erbuto, David Lester, Xenia Gonda, Zoltan Rihmer, Mario Amore, Paolo Girardi
BACKGROUND: Temperaments in completed suicides have never been assessed whereas there is substantial research on temperaments in attempted suicides and psychiatric patients. METHODS: The significant others of 18 completed suicides participated in this study in order to provide an assessment of temperaments, hopelessness, depression and the suicide risk of their loved ones. The data were compared with data from 244 psychiatric patients of whom 83 had attempted suicide in the previous month...
February 2016: Comprehensive Psychiatry
Gianni L Faedda, Ciro Marangoni, Giulia Serra, Paola Salvatore, Gabriele Sani, Gustavo H Vázquez, Leonardo Tondo, Paolo Girardi, Ross J Baldessarini, Athanasios Koukopoulos
OBJECTIVE: To evaluate the presence of affective signs and symptoms as precursors of bipolar disorder in prospective studies, including assessment of their prevalence, duration, and predictive value. DATA SOURCES: We followed PRISMA guidelines to search PubMed, CINAHL, PsycINFO, EMBASE, SCOPUS, and ISI Web of Science databases to May 31, 2013, using the terms bipolar disorder AND (antecedent* OR predict* OR prodrom* OR prospect*) AND (diagnosis OR development). Hand searching of identified reports led to additional relevant references...
May 2015: Journal of Clinical Psychiatry
Giulio Perugi, Elie Hantouche, Giulia Vannucchi, Olavo Pinto
Data emerging from both academic centers and from public and private outpatient facilities indicate that from 20% to 50% of all subjects that seek help for mood, anxiety, impulsive and addictive disorders turn out, after careful screening, to be affected by cyclothymia. The proportion of patients who can be classified as cyclothymic rises significantly if the diagnostic rules proposed by the DSM-5 are reconsidered and a broader approach is adopted. Unlike the DSM-5 definition based on the recurrence of low-grade hypomanic and depressive symptoms, cyclothymia is best identified as an exaggeration of cyclothymic temperament (basic mood and emotional instability) with early onset and extreme mood reactivity linked with interpersonal and separation sensitivity, frequent mixed features during depressive states, the dark side of hypomanic symptoms, multiple comorbidities, and a high risk of impulsive and suicidal behavior...
September 1, 2015: Journal of Affective Disorders
G P Panteleeva, I V Oleĭchik, L I Abramova, P E Iumatova
OBJECTIVE: To specify clinical action of venflaxine during the course treatment of patients with different depressive states of endogenous nature. MATERIAL AND METHODS: An open naturalistic study of 32 patients with different nosological forms of endogenous depression (manic-depressive psychosis, cyclothymia, schizophrenia) was carried out. Duration of the course treatment with venflaxine (velaxin) administered in daily dose of 37,5-300 mg was 56 days. Clinical and psychometric methods were used...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Hansjörg Bäzner
Georg Friedrich Händel was not only one of the greatest musical giants ever but also he was probably the first composer who was also the manager and promoter of his own works. Various myths embellish his various biographies. This is also true for his pathography: several articles written by authors from various specialties suggested him having suffered from psychiatric diseases, like cyclothymia or mania, and rheumatologic disorders, like arthritis, while others tended to interpret his recurrent palsies as typical sequelae of ischemic strokes...
2015: Progress in Brain Research
Jonathan P Stange, Jessica L Hamilton, Taylor A Burke, Evan M Kleiman, Jared K O'Garro-Moore, Nicole D Seligman, Lyn Y Abramson, Lauren B Alloy
Rates of suicidal ideation and behavior are extremely high in bipolar spectrum disorders (BSDs). However, relatively little work has evaluated potentially synergistic relationships between cognitive and emotion-regulatory processes proposed by theoretical models of suicidality in BSDs. The present study evaluated whether negative cognitive style and subtypes of rumination would exacerbate the impact of self-criticism on suicidal ideation in a prospective study of individuals with BSDs. Seventy-two young adults with BSDs (bipolar II, bipolar NOS, or cyclothymia) completed diagnostic interviews and trait measures of self-criticism, negative cognitive style, and brooding and reflective rumination at a baseline assessment...
March 30, 2015: Psychiatry Research
Jared K O'Garro-Moore, Ashleigh Molz Adams, Lyn Y Abramson, Lauren B Alloy
BACKGROUND: Bipolar spectrum disorders (BSDs) are highly comorbid with anxiety, which is associated with an extended duration and exacerbation of depressive symptoms. Unfortunately, the underlying mechanisms are not known. This study examined the role of maladaptive cognitive styles in the co-occurrence of BSDs and anxiety disorders and prediction of depressive symptoms. METHODS: Participants included 141 young adults (69.6% female, mean age=20.24, SD=2.11), in one of three groups: a BSD group (bipolar II, cyclothymia, n=48), a comorbid BSD/anxiety group (n=50), and a demographically-matched healthy control group (n=43), who were followed prospectively...
March 15, 2015: Journal of Affective Disorders
Hannah J Stratford, Myra J Cooper, Martina Di Simplicio, Simon E Blackwell, Emily A Holmes
Comorbid anxiety is common in bipolar spectrum disorders [BPSD], and is associated with poor outcomes. Its clinical relevance is highlighted by the "anxious distress specifier" in the revised criteria for Bipolar Disorders in the Diagnostic and Statistical Manual 5th Edition [DSM-5]. This article reviews evidence for the effectiveness of psychological therapy for anxiety in adults with BPSD (bipolar I, II, not otherwise specified, cyclothymia, and rapid cycling disorders). A systematic search yielded 22 treatment studies that included an anxiety-related outcome measure...
February 2015: Clinical Psychology Review
Yingli Zhang, Huan Yang, Shichang Yang, Wei Liang, Ping Dai, Changhong Wang, Yalin Zhang
OBJECTIVE: To examine the efficacy and safety of short-term and long-term use of antidepressants in the treatment of bipolar disorder. DATA SOURCES: A literature search of randomized, double-blind, controlled trials published until December 2012 was performed using the PubMed, ISI Web of Science, Medline and Cochrane Central Register of Controlled Trials databases. The keywords "bipolar disorder, bipolar I disorder, bipolar II disorder, bipolar mania, bipolar depression, cyclothymia, mixed mania and depression, rapid cycling and bipolar disorder", AND "antidepressant agent, antidepressive agents second- generation, antidepressive agents tricyclic, monoamine oxidase inhibitor, noradrenaline uptake inhibitor, serotonin uptake inhibitor, and tricyclic antidepressant agent" were used...
November 5, 2013: Neural Regeneration Research
Dominique Eich, Alex Gamma, Tina Malti, Marianne Vogt Wehrli, Michael Liebrenz, Erich Seifritz, Jiri Modestin
BACKGROUND: The relationship between borderline personality disorder (BPD), bipolar disorder (BD), and attention deficit/hyperactivity disorder (ADHD) requires further elucidation. METHODS: Seventy-four adult psychiatric in- and out-patients, each of them having received one of these diagnoses on clinical assessment, were interviewed and compared in terms of diagnostic overlap, age and sex distribution, comorbid substance, anxiety and eating disorders, and affective temperament...
December 2014: Journal of Affective Disorders
Manuela Russo, Katie Mahon, Megan Shanahan, Elizabeth Ramjas, Carly Solon, Raphael J Braga, Katherine E Burdick
BACKGROUND: There is evidence that patients with bipolar disorder (BD) score higher on affective temperament ratings compared to healthy controls (HCs). Moreover, unaffected relatives demonstrate similar patterns as BD patients suggesting that such temperaments are related to the genetic risk for BD and may serve as endophenotypes for the disorder. It is unknown whether affective temperaments are associated with other core features of BD, such as impairments in neurocognition. This study examined the relationship between affective temperaments and neurocognition in patients with BD and in HCs...
December 2014: Journal of Affective Disorders
Maurizio Pompili, Marco Innamorati, Xenia Gonda, Denise Erbuto, Alberto Forte, Federica Ricci, David Lester, Hagop S Akiskal, Gustavo H Vázquez, Zoltan Rihmer, Mario Amore, Paolo Girardi
BACKGROUND: Mood disorders (MD) are disabling conditions throughout the world associated with significant psychosocial impairment. Affective temperaments, as well as hopelessness, may play a significant role in the pathophysiology of MD. The present study was designed to characterize patients with MD for their prevalent affective temperament and level of hopelessness. METHODS: Five hundred fifty-nine (253 men and 306 women) consecutive adult inpatients were assessed using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A), the Gotland Scale for Male Depression (GSMD), the Beck Hopelessness Scale (BHS) and the Mini International Neuropsychiatric Interview (MINI)...
September 2014: Journal of Affective Disorders
Anthony James, Uy Hoang, Valerie Seagroatt, Joe Clacey, Michael Goldacre, Ellen Leibenluft
OBJECTIVE: Controversy exists over the diagnosis and prevalence of pediatric bipolar disorder (PBD). Although several small surveys suggest that the rate of the PBD diagnosis in clinical settings is higher in the United States than in other countries, no comprehensive cross-national comparisons of clinical practice have been performed. Here, we used longitudinal national datasets from 2000 to 2010 to compare US and English hospital discharge rates for PBD in patients aged 1 to 19 years...
June 2014: Journal of the American Academy of Child and Adolescent Psychiatry
Christoph U Correll, Doreen M Olvet, Andrea M Auther, Marta Hauser, Taishiro Kishimoto, Ricardo E Carrión, Stephanie Snyder, Barbara A Cornblatt
OBJECTIVE: The aim of the present study was to investigate the psychometric properties of the Bipolar Prodrome Symptom Interview and Scale-Prospective (BPSS-P), the first specific interview for emerging bipolar disorder (BD) symptoms. METHODS: A total of 205 youth aged 12-23 years and/or their caregivers underwent BPSS-P interviews: 129 patients with mood spectrum disorders [depression spectrum disorder (n = 77), mood disorder not otherwise specified (NOS) (n = 27), BD-NOS (n = 14), bipolar I disorder (BD-I)/bipolar II disorder (BD-II)/cyclothymia (n = 11), 34 with non-mood spectrum disorders, and 42 healthy controls (HCs)]...
August 2014: Bipolar Disorders
G Angeletti, M D'onofrio, C Lai, R Tambelli, P Aceto, P Girardi
BACKGROUND: Evidence has shown that psychotherapy is effective for depression, whereas the outcome for suicide risk is unclear. AIM: It was to investigate whether possible pre-treatment predictors of suicide risk (SR) decrease after a brief psychodynamic psychotherapy treatment and at follow-up. PATIENTS AND METHODS: Forty-one patients were assessed at: baseline (T0) for clinical history, clinical family history, physical diseases, type of suffered abuse; after the treatment (T1); and, at six-month follow-up (T2) for mood ratings, temperamental features, and SR levels...
2014: European Review for Medical and Pharmacological Sciences
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