keyword
MENU ▼
Read by QxMD icon Read
search

Drugs

keyword
https://www.readbyqxmd.com/read/29356440/adherence-and-medication-belief-in-patients-with-pulmonary-arterial-hypertension-or-chronic-thromboembolic-pulmonary-hypertension-a-nationwide-population-based-cohort-survey
#1
Bodil Ivarsson, Roger Hesselstrand, Göran Rådegran, Barbro Kjellström
BACKGROUND: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are rare diseases with a gradual decline in physical health. Adherence to treatment is crucial in these very symptomatic and life threatening diseases. OBJECTIVE: To describe PAH and CTEPH patients experience of their self-reported medication adherence, beliefs about medicines and information about treatment. METHODS: A quantitative, descriptive, national cohort survey that included adult patients from all PAH-centres in Sweden...
January 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29356434/5-chloro-2-4-dihydroxypyridine-cdhp-prevents-lung-metastasis-of-basal-like-breast-cancer-cells-by-reducing-nascent-adhesion-formation
#2
Junji Itou, Hiroshi Tsukihara, Mamoru Nukatsuka, Masakazu Toi, Teiji Takechi
A drug for metastasis prevention is necessary. The orally administered anticancer drug S-1 contributes to cancer therapy. In a mouse xenograft model of metastatic breast cancer from our previous study, the administration of S-1 inhibited lung metastasis. However, the mechanism of inhibition remains elusive. S-1 contains 5-chloro-2,4-dihydroxypyridine (CDHP), which does not have the antigrowth activity, but prevents the degradation of 5-fluorouracil, an anticancer reagent. In this study, we found that CDHP treatment shrinks cell morphology in metastatic basal-like breast cancer cell lines...
January 22, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29356412/dna-nanotubes-with-hydrophobic-environments-toward-new-platforms-for-guest-encapsulation-and-cellular-delivery
#3
Janane F Rahbani, Empar Vengut-Climent, Pongphak Chidchob, Yasser Gidi, Tuan Trinh, Gonzalo Cosa, Hanadi F Sleiman
Natural systems combine different supramolecular interactions in a hierarchical manner to build structures. In contrast, DNA nanotechnology relies almost exclusively on DNA base pairing for structure generation. Introducing other supramolecular interactions can expand the structural and functional range of DNA assemblies, but this requires an understanding of the interplay between these interactions. Here, an economic strategy to build DNA nanotubes functionalized with lipid-like polymers is reported. When these polymers are linked to the nanotube using a spacer, they fold inside to create a hydrophobic environment within the nanotube; the nanotube can encapsulate small molecules and conditionally release them when specific DNA strands are added, as monitored by single-molecule fluorescence microscopy...
January 22, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29356400/dna-nanostructure-based-systems-for-intelligent-delivery-of-therapeutic-oligonucleotides
#4
REVIEW
Qinqin Hu, Sheng Wang, Lihua Wang, Hongzhou Gu, Chunhai Fan
In the beginning of the 21st century, therapeutic oligonucleotides have shown great potential for the treatment of many life-threatening diseases. However, effective delivery of therapeutic oligonucleotides to the targeted location in vivo remains a major issue. As an emerging field, DNA nanotechnology is applied in many aspects including bioimaging, biosensing, and drug delivery. With sequence programming and optimization, a series of DNA nanostructures can be precisely engineered with defined size, shape, surface chemistry, and function...
January 22, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29356399/sall4-khdrbs3-network-enhances-stemness-by-modulating-cd44-splicing-in-basal-like-breast-cancer
#5
Yoshiaki Matsumoto, Junji Itou, Fumiaki Sato, Masakazu Toi
Understanding the mechanism by which cancer cells enhance stemness facilitates cancer therapies. Here, we revealed that a stem cell transcription factor, SALL4, functions to enhance stemness in basal-like breast cancer cells. We used shRNA-mediated knockdown and gene overexpression systems to analyze gene functions. To evaluate stemness, we performed a sphere formation assay. In SALL4 knockdown cells, the sphere formation ability was reduced, indicating that SALL4 enhances stemness. CD44 is a membrane protein and is known as a stemness factor in cancer...
January 22, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29356380/phenyl-boronic-acids-development-led-to-validated-leads-active-in-clinical-strains-overexpressing-kpc-2-a-step-against-bacterial-resistance
#6
Giuseppe Celenza, Mattia Vicario, Pierangelo Bellio, Linciano Pasquale, Mariagrazia Perilli, Antonio Oliver, Jesus Blazquez, Laura Cendron, Donatella Tondi
The emergence and dissemination of multi drug resistant (MDR) pathogens resistant to near all available antibiotics poses a significant threat in clinical therapy. Among them, Klebsiella pneumoniae clinical isolates overexpressing KPC-2 carbapenemase are the most worrisome, extending bacterial resistance to last resort carbapenems. In this study we investigate the molecular recognition requirements in KPC-2 active site by small phenyl boronic acid derivatives. Four new phenyl boronic acid derivatives were designed and tested vs KPC-2...
January 22, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29356365/risk-network-approaches-to-locating-undiagnosed-hiv-cases-in-odessa-ukraine
#7
Pavlo Smyrnov, Leslie D Williams, Ania Korobchuk, Yana Sazonova, Georgios K Nikolopoulos, Britt Skaathun, Ethan Morgan, John Schneider, Tetyana I Vasylyeva, Samuel R Friedman
INTRODUCTION: Providing HIV healthcare and Treatment as Prevention both depend on diagnosing HIV cases, preferably soon after initial infection. We hypothesized that tracing risk networks recruits higher proportions of undiagnosed positives than outreach-based testing or respondent-driven sampling (RDS) in Odessa, Ukraine. METHODS: The Transmission Reduction Intervention Project (TRIP) used risk network tracing to recruit sexual and injection networks of recently-infected and longer-term infected (LTs) seeds (2013 to 2016)...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29356344/fabrication-of-magnetic-zinc-adeninate-metal-organic-frameworks-for-the-extraction-of-benzodiazepines-from-urine-and-wastewater
#8
Suling Zhang, Weixuan Yao, Defeng Fu, Chunxiao Zhang, Hongting Zhao
In this study, an alternative method for synthesizing magnetic cobalt adeninate metal-organic frameworks was developed, and the synthesized materials were examined for their potential application for separating and enriching benzodiazepines from complex samples. Benzodiazepines, widely used as hypnotics, muscle relaxants, sedatives, and anxiolytics, are a class of drugs that require being accurately detected and monitored. Results showed that Fe3 O4 nanoparticles could be well anchored onto the external surface of cobalt adeninate metal-organic frameworks by using amino-silane as a linkage...
January 22, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29356341/cryopreserved-neonatal-hepatocytes-may-be-a-source-for-transplantation-evaluation-of-functionality-towards-clinical-use
#9
Charlotte A Lee, Anil Dhawan, Valeria Iansante, Sharon Lehec, Shirin Elizabeth Khorsandi, Celine Filippi, Simon Walker, Raquel Fernandez-Dacosta, Nigel Heaton, Sanjay Bansal, Ragai R Mitry, Emer Fitzpatrick
Neonatal livers are a potential source of good quality hepatocytes for clinical transplantation. We compared viability and function of neonatal and adult hepatocytes, and report their clinical use both intra-portally and in alginate microbeads. Following isolation from donor livers, hepatocyte function was assessed using albumin, alpha-1 antitrypsin and factor VII. Metabolic function was investigated by measuring resorufin conjugation, ammonia metabolism, UGT enzyme activity and cytochrome P450 function following induction...
January 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29356278/antiplatelet-drug-selection-in-pci-to-vein-grafts-in-patients-with-acute-coronary-syndrome-and-adverse-clinical-outcomes-insights-from-the-british-cardiovascular-intervention-society-database
#10
Alex Sirker, Chun Shing Kwok, Evangelos Kontopantelis, Tom Johnson, Philip Freeman, Mark A de Belder, Peter Ludman, Azfar Zaman, Mamas A Mamas
OBJECTIVE: This study aims to evaluate outcomes associated with different P2Y12 agents in Saphenous Vein graft (SVG) percutaneous coronary intervention (PCI). BACKGROUND: SVG PCI is associated with greater risks of ischemic complications, compared with native coronary PCI. Outcomes associated with the use of potent P2Y12 blocking drugs, Prasugrel and Ticagrelor, in SVG PCI are unknown. METHODS: Patients included in the study underwent SVG PCI in the United Kingdom between 2007 and 2014 for acute coronary syndrome and were grouped by P2Y12 antiplatelet use...
January 22, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29356269/bioresorbable-vascular-scaffold-versus-everolimus-eluting-stents-or-drug-eluting-balloon-for-the-treatment-of-coronary-in-stent-restenosis-1-year-follow-up-of-a-propensity-score-matching-comparison-the-bioresolve-isr-study
#11
Elisabetta Moscarella, Akihito Tanaka, Alfonso Ielasi, Bernardo Cortese, Sebastian Coscarelli, Maria Carmen De Angelis, Davide Piraino, Azeem Latib, Giulietta Grigis, Renatomaria Bianchi, Dario Buccheri, Paolo Calabrò, Maurizio Tespili, Pedro Silva Orrego, Antonio Colombo, Attilio Varricchio
OBJECTIVES: to compare the 1-year outcome between bioresorbable vascular scaffold (BVS), everolimus-eluting stent (EES), and drug-eluting balloon (DEB) for in-stent restenosis (ISR) treatment. BACKGROUND: BVS has been proposed as alternative for ISR treatment. To date a direct comparison between BVS and DES or DEB for ISR treatment is lacking. METHODS: We retrospectively analyzed all ISR lesions treated with BVS, DEB, and EES from January 2012 to December 2014...
January 22, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29356244/rapid-and-efficient-generation-of-stable-antibody-drug-conjugates-via-an-encoded-cyclopropene-and-an-inverse-electron-demand-diels-alder-reaction
#12
Benjamí Oller-Salvia, Gene Kym, Jason W Chin
Homogeneous antibody-drug conjugates (ADCs), generated by site-specific toxin linkage, show improved therapeutic indices with respect to traditional ADCs. However, current methods to produce site-specific conjugates suffer from low protein expression, slow reaction kinetics and low yields, or are limited to specific conjugation sites. Here we describe high yielding expression systems that efficiently incorporate a cyclopropene derivative of lysine (CypK) into antibodies through genetic code expansion. We express trastuzumab bearing CypK and conjugate tetrazine derivatives to the antibody...
January 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29356216/treatment-gap-for-anxiety-disorders-is-global-results-of-the-world-mental-health-surveys-in-21-countries
#13
Jordi Alonso, Zhaorui Liu, Sara Evans-Lacko, Ekaterina Sadikova, Nancy Sampson, Somnath Chatterji, Jibril Abdulmalik, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Laura H Andrade, Ronny Bruffaerts, Graça Cardoso, Alfredo Cia, Silvia Florescu, Giovanni de Girolamo, Oye Gureje, Josep M Haro, Yanling He, Peter de Jonge, Elie G Karam, Norito Kawakami, Viviane Kovess-Masfety, Sing Lee, Daphna Levinson, Maria Elena Medina-Mora, Fernando Navarro-Mateu, Beth-Ellen Pennell, Marina Piazza, José Posada-Villa, Margreet Ten Have, Zahari Zarkov, Ronald C Kessler, Graham Thornicroft
BACKGROUND: Anxiety disorders are a major cause of burden of disease. Treatment gaps have been described, but a worldwide evaluation is lacking. We estimated, among individuals with a 12-month DSM-IV (where DSM is Diagnostic Statistical Manual) anxiety disorder in 21 countries, the proportion who (i) perceived a need for treatment; (ii) received any treatment; and (iii) received possibly adequate treatment. METHODS: Data from 23 community surveys in 21 countries of the World Mental Health (WMH) surveys...
January 22, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29356212/emerging-strategies-of-cancer-therapy-based-on-ferroptosis
#14
REVIEW
Zheyu Shen, Jibin Song, Bryant C Yung, Zijian Zhou, Aiguo Wu, Xiaoyuan Chen
Ferroptosis, a new form of regulated cell death that is iron- and reactive oxygen species dependent, has attracted much attention in the research communities of biochemistry, oncology, and especially material sciences. Since the first demonstration in 2012, a series of strategies have been developed to induce ferroptosis of cancer cells, including the use of nanomaterials, clinical drugs, experimental compounds, and genes. A plethora of research work has outlined the blueprint of ferroptosis as a new option for cancer therapy...
January 22, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29356211/impact-of-anti-hcv-direct-antiviral-agents-on-graft-function-and-immunosuppressive-drug-levels-in-kidney-transplant-recipients-a-call-to-attention-in-the-mid-term-follow-up
#15
Mario Fernández-Ruiz, Natalia Polanco, Ana García-Santiago, Raquel Muñoz, Ana M Hernández, Esther González, Verónica R Mercado, Inmaculada Fernández, José María Aguado, Manuel Praga, Amado Andrés
The medium-term impact on graft function and immunosuppressive drug pharmacokinetics of direct antiviral agents (DAAs) among hepatitis C virus (HCV)-infected kidney transplant (KT) recipients remains unclear. We compared pre- and post-treatment 12-month trajectories of estimated glomerular filtration rate (ΔeGFR) and 24-hour proteinuria (Δ24-hour proteinuria) in 49 recipients treated with DAAs (mostly sofosbuvir plus ledipasvir). Among evaluable patients, 66.7% and 100.0% had undetectable viral load by week 4 and end of therapy (EoT)...
January 22, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29356208/improving-recruitment-to-pharmacological-trials-for-illicit-opioid-use-findings-from-a-qualitative-focus-group-study
#16
Joanne Neale, Charlotte N E Tompkins, Rebecca McDonald, John Strang
AIM: To explore potential study participants' views on willingness to join clinical trials of pharmacological interventions for illicit opioid use to inform and improve future recruitment strategies. DESIGN: Qualitative focus group study (6 groups: oral methadone [2 groups]; buprenorphine tablets [2 groups]; injectable opioid agonist treatment [1 group]; and former opioid agonist treatment [1 group]). SETTINGS: Drug and alcohol services and a peer support recovery service (London, United Kingdom)...
January 22, 2018: Addiction
https://www.readbyqxmd.com/read/29356207/mexiletine-or-catheter-ablation-after-amiodarone-failure-in-the-vanish-trial
#17
Marc W Deyell, Christian Steinberg, Steve Doucette, Ratika Parkash, Isabelle Nault, Chris Gray, Vidal Essebag, Martin Gardner, Laurence D Sterns, Jeff S Healey, Tomasz Hruczkowski, Lena Rivard, Peter Leong-Sit, Pablo B Nery, John L Sapp
INTRODUCTION: In patients with ischemic heart disease and ventricular tachycardia (VT) refractory to high dose amiodarone, the two most common therapeutic options are adjunctive mexiletine therapy or catheter ablation. There is little existing data on the efficacy of these strategies. We examined the relative efficacy of adjunctive mexiletine and catheter ablation among patients enrolled in the VANISH trial. METHODS: All subjects enrolled in the VANISH trial who had VT refractory to high dose (≥ 300 mg daily) amiodarone at baseline were included...
January 22, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29356205/antiviral-potential-of-medicinal-plants-against-hiv-hsv-influenza-hepatitis-and-coxsackievirus-a-systematic-review
#18
REVIEW
Muhammad Akram, Imtiaz Mahmood Tahir, Syed Muhammad Ali Shah, Zahed Mahmood, Awais Altaf, Khalil Ahmad, Naveed Munir, Muhammad Daniyal, Suhaila Nasir, Huma Mehboob
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections...
January 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29356180/severe-adverse-cutaneous-drug-reactions-to-antiepileptic-drugs-18-years-of-experience-in-a-tertiary-referral-dermatology-clinic-in-turkey
#19
E Özkaya, S Kılıç
Antiepileptic drugs (AEDs) are the mainstay of treatment for 1% of the human population suffering from epilepsy.1 They are also increasingly used for several non-epileptic neurological conditions, such as trigeminal neuralgia, neuropathic pain syndromes, migraine and psychiatric disorders.2 Three percent of patients who receive AEDs experience adverse cutaneous drug reactions (ACDR),3 which can range across a wide spectrum from mild to moderate eruptions, such as maculopapular rash and, urticaria, to severe and life-threatening conditions, such as drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN)...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29356147/kisspeptin-neurones-in-the-posterodorsal-medial-amygdala-modulate-sexual-partner-preference-and-anxiety-in-male-mice
#20
D A Adekunbi, X F Li, G Lass, K Shetty, O A Adegoke, S H Yeo, W H Colledge, S L Lightman, K T O'Byrne
The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is however limited information on the specific neuronal cell type in the MePD functionally mediating these behaviours in rodents. The recent discovery of a significant kisspeptin neurone population in the MePD has raised interest in the possible role of kisspeptin and its cognate receptor in sexual behaviour. This study therefore tested the hypothesis that the MePD kisspeptin neurone population is involved in regulating attraction towards opposite sex conspecifics, sexual behaviour, social interaction and anxiety response by selectively stimulating these neurones using the novel pharmacosynthetic DREADDs (designer receptors exclusively activated by designer drugs) technique...
January 22, 2018: Journal of Neuroendocrinology
keyword
keyword
2429
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"