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JOURNAL ARTICLE
Trinidad León-Quinto, Roque Madrigal, Esteban Cabello, Antonio Fimia, Arturo Serna
As traditionally cold areas become warmer due to climate change, temperature could no longer be a barrier to the establishment of non-native insects. This is particularly relevant for pest insects from warm and tropical areas, mainly those with some tolerance to moderately low temperatures, which could expand their range into these new locations. From this perspective, in this work we studied the morphological and biochemical responses of the Neotropical pest Paysandisia archon to low temperatures, as part of a possible strategy to colonize new areas...
January 24, 2024: Journal of Thermal Biology
#22
Jana G Hashash, Jaclyn Elkins, James D Lewis, David G Binion
DESCRIPTION: Diet plays a critical role in human health, but especially for patients with inflammatory bowel disease (IBD). Guidance about diet for patients with IBD are often controversial and a source of uncertainty for many physicians and patients. The role of diet has been investigated as a risk factor for IBD etiopathogenesis and as a therapy for active disease. Dietary restrictions, along with the clinical complications of IBD, can result in malnutrition, an underrecognized condition among this patient population...
January 23, 2024: Gastroenterology
#23
REVIEW
Abdullah A Cheema, Haider R Cheema
Diabetic macular edema (DME) is a major cause of vision impairment in diabetic individuals, characterized by fluid accumulation in the macula due to a breakdown of the blood-retinal barrier (BRB). This review article explores the role of anti-vascular endothelial growth factor (anti-VEGF) therapies in the management of DME. Anti-VEGF treatments, including ranibizumab, bevacizumab, and aflibercept, have revolutionized DME management by targeting VEGF, a key mediator in DME pathogenesis. We critically examined the efficacy of these therapies in reducing macular edema and improving visual acuity, assessed their safety and tolerability, and explored the variability in treatment response...
January 2024: Curēus
#24
RANDOMIZED CONTROLLED TRIAL
M Cantillon, N Andreasen, N Prins
BACKGROUND: KHK6640 is a novel humanized anti-amyloid beta oligomer-specific antibody. Both KHK6640 and the mouse parent antibody E64 have demonstrated high potency and efficacy for cognitive improvement in several rodent Alzheimer's disease models, including an anti-amyloid beta injection mouse model and in age-matched double transgenic littermates. The favorable safety and pharmacokinetic profiles of KHK6640 reported in preclinical studies warrant clinical trials in Alzheimer's disease patients...
2024: Journal of Prevention of Alzheimer's Disease
#25
JOURNAL ARTICLE
Yan Liang, Hailing Zhang, Jiahui Li, Xilong Wang, Jianpeng Xie, Yijian Li, Jiehong Li, Yunyao Qian, Haiyun Zhang, Tao Wang, Haixiong Tang, Xin Chen
Acute lung injury (ALI) is a severe disease with high mortality and poor prognosis, characterized by excessive and uncontrolled inflammatory response. Vascular endothelial growth factor A (VEGF-A) contributes to the development and progression of ALI. The aim of this study was to evaluate the role of glucose transporter 1 (GLUT1) in alveolar epithelial VEGF-A production in lipopolysaccharide (LPS)-induced ALI. An ALI mouse model was induced by LPS oropharyngeal instillation. Mice were challenged with LPS and then treated with WZB117, a specific antagonist of GLUT1...
January 15, 2024: Cell Biology International
#26
JOURNAL ARTICLE
Jon-Émile S Kenny, Ross Prager, Philippe Rola, Korbin Haycock, Stanley O Gibbs, Delaney H Johnston, Christine Horner, Joseph K Eibl, Vivian C Lau, Benjamin O Kemp
Background: The likelihood of a patient being preload responsive-a state where the cardiac output or stroke volume (SV) increases significantly in response to preload-depends on both cardiac filling and function. This relationship is described by the canonical Frank-Starling curve. Research Question : We hypothesize that a novel method for phenotyping hypoperfused patients (ie, the "Doppler Starling curve") using synchronously measured jugular venous Doppler as a marker of central venous pressure (CVP) and corrected flow time of the carotid artery (ccFT) as a surrogate for SV will refine the pretest probability of preload responsiveness/unresponsiveness...
January 8, 2024: Journal of Intensive Care Medicine
#27
JOURNAL ARTICLE
Clotilde Boudousq, Vuong Nguyen, Adrian Hunt, Mark Gillies, Javier Zarranz-Ventura, Louise O'Toole, Els Mangelschots, Pavol Kusenda, Ursula Schmidt-Erfurdt, Andreas Pollreisz, Wajiha Jurdi Kheir, Carolina Arruabarrena, Stela Vujosevic, Daniel Barthelmes, Catherine Creuzot-Garcher, Pierre-Henry Gabrielle
PURPOSE: To evaluate the proportion, predictors and outcomes of neovascular age-related macular degeneration (nAMD) patients treated with a high burden of vascular endothelial growth factor (VEGF) inhibitor injections (IVT) after two years in routine clinical practice. DESIGN: Retrospective analysis of data from a prospectively designed observational outcomes registry, Fight Retinal Blindness! project, of patients treated in European centers. PARTICIPANTS: Treatment-naïve eyes (one eye per patient) starting VEGF inhibitors for nAMD from January 2017 to March 2020 with 24 months of follow-up...
January 5, 2024: Ophthalmology Retina
#28
JOURNAL ARTICLE
Ning Wang, Fei-Li Chen, Lu Pan, Yan Teng, Xiao-Juan Wei, Han-Guo Guo, Xin-Miao Jiang, Ling Huang, Si-Chu Liu, Zhan-Li Liang, Wen-Yu Li
BACKGROUND: High-dose methotrexate (HD-MTX) combined with other chemotherapeutic agents is an effective treatment for patients with newly diagnosed primary central nervous system lymphoma (PCNSL); however, some patients have adverse reactions. AIM: To retrospectively evaluate disease outcomes and mutational profiles in newly diagnosed PCNSL patients treated with a zanubrutinib/HD-MTX combination regimen. METHODS: Nineteen newly diagnosed PCNSL patients were treated with zanubrutinib/HD-MTX until disease progression, intolerable toxicities, or physician/patient-directed withdrawal...
December 24, 2023: World Journal of Clinical Oncology
#29
JOURNAL ARTICLE
Matt Haley, Nasim Khosravi Foroutan, Juliann M Gronquist, Raju Reddy, Raghav Wusirika, Akram Khan
Managing sepsis and fluid resuscitation in patients with chronic kidney disease or end-stage renal disease is challenging for health care providers. Nurses are essential for early identification and treatment of these patients. Nurse education on assessing perfusion and implementing 3-hour bundled care can improve mortality rates in patients with sepsis. In this scoping review, initial screening identified 1176 articles published from 2015 through 2023 in the National Library of Medicine database; 29 articles were included in the literature summary and evidence synthesis...
January 1, 2024: American Journal of Critical Care
#30
Diamantina Marouli, Charalampos Pappas, Maria Raissaki, Athanasia Proklou, Eleftherios Papadakis, Eumorfia Kondili
INTRODUCTION: Intravesical Bacillus Calmette-Guérin (BCG) instillation is the most effective adjuvant therapy for superficial urinary bladder carcinoma, prolonging disease-free survival. Although it is usually well tolerated, moderate to severe local or systemic infectious complications, including sepsis involving multiple organs, may occur. CASE REPORT: We report the unusual case of a man in his mid '70s who presented with septic shock and severe acute respiratory failure requiring intubation...
September 2023: Germs
#31
JOURNAL ARTICLE
Jonathan Y B Jedal, Anders Malmendal, Hans Ramløv
The larvae of the black headed cardinal beetle Pyrochroa coccinea, overwinters under the bark of dead logs in northern European dioecious forests, and are thus exposed to temperatures below the melting point of their bodily fluids. Here we explore the mechanisms behind their seasonal cold hardening by characterising field samples collected monthly throughout the year. Both the lower lethal temperature and supercooling point dropped as much as 10℃ in the second half of November, reaching values around -15℃ by the beginning of December...
December 23, 2023: Journal of Insect Physiology
#32
JOURNAL ARTICLE
Hongling Zhang, Feilong Sun, Wenbing Zhang, Xia Gao, Lei Du, Xiaopeng Yun, Yanyan Li, Ling Li, Baoping Pang, Yao Tan
Galeruca daurica (Joannis) is a pest species with serious outbreaks in the Inner Mongolian grasslands in recent years, and its larvae and eggs are extremely cold-tolerant. To gain a deeper understanding of the molecular mechanism of its cold-tolerant stress response, we performed de novo transcriptome assembly of G. daurica via RNA-Seq and compared the differentially expressed genes (DEGs) of first- and second-instar larvae grown and developed indoors and outdoors, respectively. The results show that cold tolerance in G...
December 4, 2023: Genes
#33
JOURNAL ARTICLE
Jon-Émile S Kenny, Ross Prager, Philippe Rola, Korbin Haycock, John Basmaji, Glenn Hernández
Point of care ultrasound (POCUS) is a first-line tool to assess hemodynamically unstable patients, however, there is confusion surrounding intertwined concepts such as: "flow," "congestion," "fluid responsiveness (FR)," and "fluid tolerance." We argue that the Frank-Starling relationship is clarifying because it describes the interplay between "congestion" and "flow" on the x -axis and y -axis, respectively. Nevertheless, a single, simultaneous assessment of congestion and flow via POCUS remains a static approach...
December 2023: Critical care explorations
#34
JOURNAL ARTICLE
Amber M Lum, Sarah N Miller, Tonya M Clauss, Chelsea E Anderson
Two cownose rays (Rhinoptera bonasus) presented for management of a severe capsalid monogenean infection (Benedeniella posterocolpa) in a mixed species habitat at an aquarium. A series of freshwater (FW) dips were elected to mitigate parasite resistance to praziquantel due to the endemic monogenean population in the system. A pre-treatment blood sample was opportunistically obtained, and subsequent samples were processed due to development of clinical signs. While the first FW dip was tolerated well and did not induce abnormal behavior, the second led to one individual presenting with tachypnea, pallor, and lethargy...
December 5, 2023: Journal of Aquatic Animal Health
#35
JOURNAL ARTICLE
Wenchao Deng, Zihao Zhao, Yufang Li, Rongguang Cao, Mingming Chen, Kai Tang, Deli Wang, Wei Fan, Anyi Hu, Guangcheng Chen, Chen-Tung Arthur Chen, Yao Zhang
BACKGROUND: Active hydrothermal vents create extreme conditions characterized by high temperatures, low pH levels, and elevated concentrations of heavy metals and other trace elements. These conditions support unique ecosystems where chemolithoautotrophs serve as primary producers. The steep temperature and pH gradients from the vent mouth to its periphery provide a wide range of microhabitats for these specialized microorganisms. However, their metabolic functions, adaptations in response to these gradients, and coping mechanisms under extreme conditions remain areas of limited knowledge...
December 5, 2023: Microbiome
#36
JOURNAL ARTICLE
Maurizio A Leone, Maurizio Gelati, Daniela C Profico, Claudio Gobbi, Emanuele Pravatà, Massimiliano Copetti, Carlo Conti, Lucrezia Abate, Luigi Amoruso, Francesco Apollo, Rosario F Balzano, Ilaria Bicchi, Massimo Carella, Alessandro Ciampini, Carlo Colosimo, Paola Crociani, Giada D'Aloisio, Pietro Di Viesti, Daniela Ferrari, Danilo Fogli, Andrea Fontana, Domenico Frondizi, Valentina Grespi, Jens Kuhle, Antonio Laborante, Ivan Lombardi, Gianmarco Muzi, Francesca Paci, Giuliana Placentino, Teresa Popolizio, Claudia Ricciolini, Simonetta Sabatini, Giada Silveri, Cristina Spera, Daniel Stephenson, Giuseppe Stipa, Elettra Tinella, Michele Zarrelli, Chiara Zecca, Yendri Ventura, Angelo D'Alessandro, Luca Peruzzotti-Jametti, Stefano Pluchino, Angelo L Vescovi
We report the analysis of 1 year of data from the first cohort of 15 patients enrolled in an open-label, first-in-human, dose-escalation phase I study (ClinicalTrials.gov: NCT03282760, EudraCT2015-004855-37) to determine the feasibility, safety, and tolerability of the transplantation of allogeneic human neural stem/progenitor cells (hNSCs) for the treatment of secondary progressive multiple sclerosis. Participants were treated with hNSCs delivered via intracerebroventricular injection in combination with an immunosuppressive regimen...
December 7, 2023: Cell Stem Cell
#37
JOURNAL ARTICLE
Melanie Shulman, Jessica Kong, John O'Gorman, Elena Ratti, Rajasimhan Rajagovindan, Louis Viollet, Ellen Huang, Sanjiv Sharma, Annie M Racine, Julie Czerkowicz, Danielle Graham, Yumeng Li, Heike Hering, Samantha Budd Haeberlein
In Alzheimer's disease, the spread of aberrantly phosphorylated tau is an important criterion in the Braak staging of disease severity and correlates with disease symptomatology. Here, we report the results of TANGO ( NCT03352557 ), a randomized, double-blind, placebo-controlled, parallel-group and multiple-dose long-term trial of gosuranemab-a monoclonal antibody to N-terminal tau-in patients with early Alzheimer's disease. The primary objective was to assess the safety and tolerability of gosuranemab compared to placebo...
November 27, 2023: Nature aging
#38
JOURNAL ARTICLE
Noemí Tomsen, Mireia Bolívar-Prados, Omar Ortega, Pere Clavé
ThickenUp® Gel Express (TUGE) is a new, xanthan- and acacia-gum-based, liquid, thickening product. In independently living older adults with oropharyngeal dysphagia (OD), we assessed: (1) the rheological properties of TUGE; (2) its therapeutic effect at four viscosity levels (achieved by 5 g, 10 g, 20 g and 30 g of TUGE in water + Omnipaque X-ray contrast) versus thin liquid; and (3) the effect on hydration status and gastrointestinal tolerance after fourteen days. Shear viscosity of TUGE was measured in SI units (mPa·s at 50 s-1 )...
October 31, 2023: Nutrients
#39
JOURNAL ARTICLE
Kulley Ackah Grace, Senoo-Dogbey Vivian Efua
BACKGROUND: For pediatric patients, the demand for quality and safe Intravenous Fluid (IVF) therapy is huge. This is because, compared to adults, children have a lower tolerance for IVF therapy errors and present devastating physiological responses to errors. Nurses play a vital role in IVF administration; therefore, adequate knowledge, positive attitudes, positive perceived behavioural control, and good behavioural intentions are required to achieve effective and successful therapy, patient safety and prevention of complications, and overall positive patient outcomes...
November 11, 2023: Journal of Pediatric Nursing
#40
REVIEW
Philippe Rola, Korbin Haycock, Rory Spiegel
Assessment of the IVC by point-of-care ultrasound in the context of resuscitation has been a controversial topic in the last decades. Most of the focus had been on its use as a surrogate marker for fluid responsiveness, with results being equivocal. We review its important anatomical aspects as well as the physiological rationale behind ultrasound assessment and propose a new way to do so, as well as explain its central role in the concept of fluid tolerance.
April 2024: Journal of Critical Care
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