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Cefotaxime

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https://www.readbyqxmd.com/read/29782210/colonization-with-enterobacteriaceae-producing-esbls-ampcs-and-oxa-48-in-wild-avian-species-spain-2015-2016
#1
Jesús Oteo, Aida Mencía, Verónica Bautista, Natalia Pastor, Noelia Lara, Fernando González-González, Francisco Javier García-Peña, José Campos
Antibiotic resistance is a global threat of complex and changeable epidemiology. The role of wild birds in the dissemination of antibacterial resistance might be underestimated. We studied the cloacal colonization by cefotaxime-resistant Enterobacteriaceae in 668 wild birds in Spain. Eighty-eight wild birds (13.2%) of 28 species carried cefotaxime-resistant isolates; 58 of them (8.7%) carried extended-spectrum β-lactamases (ESBLs) and 15 (2.5%) plasmid-mediated AmpCs of the blaCIT family. The 58 ESBLs belonged to the CTX-M-1 group (63...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29776449/imipenem-resistance-in-clinical-escherichia-coli-from-qom-iran
#2
Saeed Shams, Ali Hashemi, Mohammad Esmkhani, Somaye Kermani, Elham Shams, Alessandra Piccirillo
OBJECTIVE: The emergence of metallo-β-lactamase-producing Enterobacteriaceae is a worldwide health concern. In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and blood specimens in Qom, Iran is described. Three hundred urine and blood specimens were analysed to detect the presence of E. coli. Resistance to imipenem and other antimicrobials was determined by disk diffusion and MIC. MBL production was screened using CDDT...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776398/primary-bacterial-ventriculitis-in-adults-an-emergent-diagnosis-challenge-report-of-a-meningoccal-case-and-review-of-the-literature
#3
Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff, François Caron
BACKGROUND: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. CASE PRESENTATION: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29774212/alkaline-peptone-water-based-enrichment-method-for-mcr-3-from-acute-diarrheic-outpatient-gut-samples
#4
Qiaoling Sun, Yanyan Hu, Hongwei Zhou, Lingbin Shu, Hanyu Wang, Zixian Huang, Rong Zhang
A third plasmid-mediated colistin resistance gene, mcr-3 , is increasingly being reported in Enterobacteriaceae and Aeromonas spp. from animals and humans. To investigate the molecular epidemiology of mcr in the gut flora of Chinese outpatients, 152 stool specimens were randomly collected from outpatients in our hospital from May to June, 2017. Stool specimens enriched in alkaline peptone water or Luria-Bertani (LB) broth were screened for mcr-1, mcr-2 , and mcr-3 using polymerase chain reaction (PCR)-based assays...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29768458/burden-of-bacterial-meningitis-in-india-preliminary-data-from-a-hospital-based-sentinel-surveillance-network
#5
Yuvaraj Jayaraman, Balaji Veeraraghavan, Girish Kumar Chethrapilly Purushothaman, Bharathy Sukumar, Boopathi Kangusamy, Ambujam Nair Kapoor, Nivedita Gupta, Sanjay Madhav Mehendale
BACKGROUND: Worldwide, acute bacterial meningitis is a major cause of high morbidity and mortality among under five children, particularly in settings where vaccination for H. influenzae type b, S. pneumoniae and N. meningitidis is yet to be introduced in the national immunization programs. Estimation of disease burden of bacterial meningitis associated with these pathogens can guide the policy makers to consider inclusion of these newer vaccines in the immunization programs. A network of hospital based sentinel surveillance was established to generate baseline data on the burden of bacterial meningitis among children aged less than 5 years in India and to provide a platform for impact assessment following introduction of the Pentavalent and Pneumococcal Conjugate Vaccines (PCV)...
2018: PloS One
https://www.readbyqxmd.com/read/29764503/bacteriological-profile-of-neonatal-sepsis-and-antibiotic-susceptibility-pattern-of-isolates-admitted-at-kanti-children-s-hospital-kathmandu-nepal
#6
Nikita Singh Yadav, Saroj Sharma, Dhiraj Kumar Chaudhary, Prabhat Panthi, Pankaj Pokhrel, Anil Shrestha, Pappu Kumar Mandal
OBJECTIVE: Neonatal sepsis is a major cause of morbidity and mortality of newborns (< 1 month of age). Septicemia and drug resistance is a predominant issue for neonatal death in Nepal. This study is intended to find bacteriological profile of neonatal sepsis and antibiotic susceptibility pattern of the isolates from neonates at Kanti Children's Hospital, Kathmandu, Nepal. RESULTS: Out of 350 suspected cases of neonatal sepsis, 59 (16.9%) cases showed positive blood culture...
May 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29750591/salmonella-species-persistence-and-their-high-level-of-antimicrobial-resistance-in-flooded-man-made-rivers-in-china
#7
Qifa Song, Danyang Zhang, Hong Gao, Junhua Wu
Man-made rivers, owing to proximity to human habitats, facilitate transmission of salmonellosis to humans. To determine the contamination situation by Salmonella in flooded man-made rivers and thereafter the exposure risk to public health, we investigated the prevalence of Salmonella species and their antimicrobial resistance in such rivers, as well as the relationship between the incidence of local infectious diarrhea cases and the number of Salmonella isolates from patients. After a heavy flood, 95 isolates of 13 Salmonella serotypes were isolated from 80 river water samples...
May 11, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29744228/successful-treatment-of-high-level-aminoglycoside-resistant-enterococcus-faecalis-bacteremia-in-a-preterm-infant-with-ampicillin-and-cefotaxime
#8
Jennifer Tam, Santina J Lee, Vibhuti Shah, Shaun K Morris
Enterococcal bloodstream infections are usually treated with single-agent antibiotics. In persistent infections, synergistic combination therapy is often required with a beta-lactam and an aminoglycoside antibiotic. High-level aminoglycoside-resistant (HLAR) enterococci are increasingly prevalent and preclude the use of this combination. The use of ampicillin with a third-generation cephalosporin to treat endovascular HLAR Enterococcus infections is becoming more established in the adult population; however, the literature on treatment of such infections in children remains scarce...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29732983/an-outbreak-of-esbl-producing-klebsiella-pneumoniae-in-an-iranian-referral-hospital-epidemiology-and-molecular-typing
#9
Shima Mahmoudi, Babak Pourakbari, Aliakbar Rahbarimanesh, Mohammad Reza Abdolsalehi, Keyghobad Ghadiri, Setareh Mamishi
INTRODUCTION: Klebsiella pneumoniae is a common cause of nosocomial infections; however, there is limited information in Iran regarding nosocomial outbreaks due to extended-spectrum β-lactamase (ESBL) producing K pneumoniae strains, particularly using molecular methods. The present study focused on the molecular mechanism of ESBL resistance and genetic relatedness in K. pneumoniae isolates causing nosocomial infections in an Iranian referral hospital. MATERIAL AND METHODS: This study was evaluated the antimicrobial resistance and molecular epidemiology of K...
May 7, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29732380/antimicrobial-agent-shortages-the-new-norm-for-infectious-diseases-physicians
#10
Adi V Gundlapalli, Susan E Beekmann, Donald R Graham, Philip M Polgreen
Background: In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of antimicrobial agents. Methods: We used a web-based survey of ID physician members of the Emerging Infections Network in 2016. Results: Of the 701 of 1597 members (44%) who responded, 70% reported the need to modify their antimicrobial choice because of a shortage in the prior 2 years...
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29729705/multidrug-resistance-prevalence-and-phylogenetic-analysis-of-genes-encoding-class-ii-and-iii-integrons-in-clinically-isolated-escherichia-coli
#11
Manal Mohamed Elhassan Taha, Hisham Elraih Homeida, Omer Mohammed Elhassan Dafalla, Siddig Ibrahim Abdelwahab
The present study was conducted to evaluate the susceptibility, multidrug resistance and genetic characteristics of Escherichia coli (E. coli) strains, isolated from clinical samples from Jazan Hospital, Jazan, Saudi Arabia. A total of 95 samples were recruited from wound, urine, stool and blood. The isolates were assessed for their antibiotic susceptibilities and the presence of class II and III integrons was studied using PCR technique. Integron II-positive PCR products were further confirmed using partial sequencing...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29729515/pharmaceutically-active-compounds-in-the-xiangjiang-river-china-distribution-pattern-source-apportionment-and-risk-assessment
#12
Huiju Lin, Leilei Chen, Haipu Li, Zhoufei Luo, Jing Lu, Zhaoguang Yang
The occurrence of 36 pharmaceutically active compounds in surface water of the Xiangjiang River was investigated in two seasons (n = 38). Twenty-five of these compounds were detected, with cefotaxime (maximum concentration 830 ng L-1 ) the most abundant compound followed by amoxicillin (maximum concentration 710 ng L-1 ). The spatiotemporal distribution was observed; indicating that pollution hotspots were mostly located in economically developed and densely populated regions such as Changsha City...
May 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29729161/antimicrobial-susceptibility-patterns-of-escherichia-coli-in-children-and-adults-with-urinary-tract-infections
#13
Yaroslav O Mykhalko
OBJECTIVE: Introduction: Urinary tract infections (UTIs) are common pathology in children and adults that is caused mainly by Gram-negative bacteria among which Escherichia coli plays an outstanding role. UTIs treatment demands empiric antibiotic therapy and knowing of antimicrobial local susceptibility and resistance patterns is crucial for making a decision about an agent for the first line therapy. The aim of this study was to evaluate the local susceptibility patterns of uropathogenic E...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29728084/group-b-streptococci-vaginal-colonization-and-drug-susceptibility-pattern-among-pregnant-women-attending-in-selected-public-antenatal-care-centers-in-addis-ababa-ethiopia
#14
Solomon Assefa, Kassu Desta, Tsehaynesh Lema
BACKGROUND: Group B Streptococcus (GBS) is the leading cause of septicemia, meningitis, and pneumonia in neonates. Maternal colonization with GBS is the principal risk factor for early-onset disease in infants. Group B Streptococcus is now an important cause of maternal and neonatal morbidity and mortality in many parts of the world. In Ethiopia, few studies have been done on GBS colonization among pregnant women. The aim of this study was to determine the prevalence of GBS colonization, antimicrobial susceptibility patterns and assess risk factors among pregnant women...
May 4, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29726697/antibacterial-activity-of-thymus-vulgaris-essential-oil-alone-and-in-combination-with-cefotaxime-against-bla-esbl-producing-multidrug-resistant-enterobacteriaceae-isolates
#15
Qada Benameur, Teresa Gervasi, Vito Pellizzeri, Mária Pľuchtová, Hassiba Tali-Maama, Farida Assaous, Badia Guettou, Kheira Rahal, Daniela Gruľová, Giacomo Dugo, Andreana Marino, Meriem-Hind Ben-Mahdi
The aim was to evaluate the susceptibility of blaESBL producing Enterobacteriaceae to Slovakian Thymus vulgaris essential oil (TVEO) alone and in combination with cefotaxime (CTX). TVEO composition was determined by gas chromatograph-mass spectrometer (GC/MS). Susceptibility to 21 antibiotics was determined by disc diffusion assay. Genes characterization for resistance to β-lactams was accomplished by polymerase chain reaction (PCR). The antibacterial activity was investigated by standard methods. The synergistic interaction was determined by checkerboard test...
May 4, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29726023/the-determination-of-capreomycin-in-human-plasma-by-lc-ms-ms-using-ion-pairing-chromatography-and-solid-phase-extraction
#16
Blessings Thuboy, Tracy Kellermann, Sandra Castel, Jennifer Norman, Anton Joubert, Anthony J Garcia-Prats, Anneke C Hesseling, Lubbe Wiesner
A bioanalytical method was developed and validated for the quantification of Capreomycin (Cm) analogues, Cm IA and Cm IB, in human plasma. This implemented ion-pairing solid phase extraction (IP-SPE), followed by ion-pairing high performance liquid chromatography (IP-HPLC), with tandem mass spectrometry detection. Chromatographic separation was achieved using a Discovery C18, 5μm, 4.6 mm x 50 mm analytical column. An isocratic mobile phase consisting of water and acetonitrile with 0.1% formic acid and 4 mM Heptafluorobutyric acid (80,20; v/v), was used at a flow-rate of 500 μl per minute...
May 3, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29692577/antibiotic-susceptibility-pattern-of-shigella-isolates-in-a-tertiary-healthcare-center
#17
Anitha Madhavan, Sobha Balakrishnan, Jayalakshmi Vasudevapanicker
BACKGROUND AND OBJECTIVES: Shigellosis is one of the most common causes of morbidity and mortality in children in developing countries. To the best of our knowledge, there is no published data in the study area on the antimicrobial susceptibility pattern and prevalence of Shigella species among diarrheagenic cases. Therefore, a retrospective analysis was done to find the Shigella serotypes, common age group affected, and antimicrobial resistance pattern of Shigella isolates in South Kerala...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29682477/identification-of-extended-spectrum-beta-lactamases-ampc-and-carbapenemase-production-among-isolates-of-escherichia-coli-in-north-indian-tertiary-care-centre
#18
Uma Chaudhary, Shipra Agarwal, Kausalya Raghuraman
Introduction: Identification of Extended spectrum beta lactamases (ESBL), AmpC production and carbapenemase production among isolates of Escherichia coli , helps clinician to rationalize the choice of antibiotics. However, there is a lack of simple and effective method for simultaneous identification of these beta lactamases. Aim: To determine the concurrent production of beta lactamases using twelve disc method on E. coli isolates. Materials and Methods: A total of 200 multidrug resistant E...
April 2018: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29678565/simplification-of-first-line-antibacterial-regimen-for-complicated-appendicitis-in-children-was-associated-with-better-adherence-to-guidelines-and-reduced-use-of-antibiotics
#19
Marion Taleb, Nicolas Nardi, Alexis Arnaud, Nathalie Costet, Pierre-Yves Donnio, Charlotte Engrand, Edouard Habonimana, Eric Wodey, Pierre Tattevin
Acute appendicitis in children requires early surgery, and a short course of antibiotics active on Enterobacteriaceae and anaerobes. Although aminoglycoside-containing 3-drug regimen have been used successfully for decades, simpler regimens with similar efficacy are increasingly used. We aimed to evaluate the impact of a switch from the combination of cefotaxime, metronidazole, and gentamicin (regimen 1), to piperacillin-tazobactam (regimen 2), as first-line regimen for complicated acute appendicitis in children...
April 17, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29677683/application-of-solid-phase-microextraction-followed-by-liquid-chromatography-mass-spectrometry-in-the-determination-of-antibiotic-drugs-and-their-metabolites-in-human-whole-blood-and-tissue-samples
#20
Malgorzata Szultka-Mlynska, Pawel Pomastowski, Boguslaw Buszewski
A sensitive, rapid and specific analytical method using high performance liquid chromatography coupled with mass spectrometry (HPLC-QqQ-MS) was developed to determine selected antibiotic drugs and their metabolites (amoxicillin, cefotaxime, ciprofloxacin, clindamycin and metronidazole; amoxycilloic acid, 4-hydroxyphenyl glycyl amoxicillin, desacetyl cefotaxime, 3-desacetyl cefotaxime lactone, ciprofloxacin N-oxide, N-demethylclindamycin, clindamycin sulfoxide, and hydroxy metronidazole) in human whole blood and vascularized tissue after single oral administration...
April 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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