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Functional Classification

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https://www.readbyqxmd.com/read/28102830/can-exhaled-volatile-organic-compounds-predict-asthma-exacerbations-in-children
#1
Dillys van Vliet, Agnieszka Smolinska, Quirijn Jöbsis, Jean Muris, Philippe Rosias, Jan Dallinga, Edward Dompeling, Frederik van Schooten
Background Asthma control falls short of current goals of asthma management guidelines. Non-invasive monitoring of airway inflammation may help to improve the level of asthma control in children. Aim 1) To identify a set of exhaled volatile organic compounds (VOCs) that is most predictive for an asthma exacerbation in children. 2) To determine the chemical background of predictive VOCs. Methods In an one-year prospective observational study, 96 asthmatic children were studied . At clinical visits with an interval of 2 months, asthma control, fractional exhaled nitric oxide, lung function (FEV1, FEV1/VC) and VOCs in exhaled breath were determined by means of gas chromatography time-of-flight mass spectrometry...
January 19, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28102546/ataluren-and-similar-compounds-specific-therapies-for-premature-termination-codon-class-i-mutations-for-cystic-fibrosis
#2
REVIEW
Aisha A Aslam, Colin Higgins, Ian P Sinha, Kevin W Southern
BACKGROUND: Cystic fibrosis is a common life-shortening genetic disorder in the Caucasian population (less common in other ethnic groups) caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces and the mutation most notably affects the airways. In the lungs of people with cystic fibrosis, defective protein results in a dehydrated surface liquid and compromised mucociliary clearance...
January 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28102465/risks-and-benefits-of-phase-i-liver-dysfunction-studies-should-patients-with-severe-liver-dysfunction-be-included-in-these-trials
#3
Christos Fountzilas, Selena Stuart, Brian Hernandez, Elizabeth Bowhay-Carnes, Joel Michalek, John Sarantopoulos, Anand Karnad, Sukeshi Patel, Steven Weitman, Devalingam Mahalingam
Introduction The goal of organ dysfunction Phase I trials is to characterize the safety and pharmacokinetics of novel agents in cancer patients with liver or kidney dysfunction, but the clinical benefit is not well established. Methods We reviewed 170 patients across 15 liver dysfunction studies at our institution, grouped based on the NCI-Organ Dysfunction Working Group criteria or Child-Pugh Score. Results The median survival for the entire cohort was two months and just one month amongst patients with severe liver dysfunction...
January 19, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28101883/mytreehouse-self-concept-assessment-preliminary-psychometric-analysis-of-a-new-self-concept-assessment-for-children-with-cerebral-palsy
#4
Sau Kuan Cheong, Cathryne P Lang, Sheryl A Hemphill, Leanne M Johnston
AIM: To evaluate the preliminary validity and reliability of the myTREEHOUSE Self-Concept Assessment for children with cerebral palsy (CP) aged 8 to 12 years. METHOD: The myTREEHOUSE Self-Concept Assessment includes 26 items divided into eight domains, assessed across three Performance Perspectives (Personal, Social, and Perceived) and an additional Importance Rating. Face and content validity was assessed by semi-structured interviews with seven expert professionals regarding the assessment construct, content, and clinical utility...
January 19, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28101681/extended-liver-venous-deprivation-before-major-hepatectomy-induces-marked-and-very-rapid-increase-in-future-liver-remnant-function
#5
Boris Guiu, François Quenet, Laure Escal, Frédéric Bibeau, Lauranne Piron, Philippe Rouanet, Jean-Michel Fabre, Eric Jacquet, Alban Denys, Pierre-Olivier Kotzki, Daniel Verzilli, Emmanuel Deshayes
OBJECTIVE: The aim of this study was to assess the safety and efficacy of extended liver venous deprivation (eLVD), i.e. combination of right portal vein embolisation and right (accessory right) and middle hepatic vein embolisation before major hepatectomy for future remnant liver (FRL) functional increase. METHODS: eLVD was performed in non-cirrhotic patients referred for major hepatectomy in a context of small FRL (baseline FRL <25% of the total liver volume or FRL function <2...
January 18, 2017: European Radiology
https://www.readbyqxmd.com/read/28101424/detection-and-classification-of-three-class-initial-dips-from-prefrontal-cortex
#6
Amad Zafar, Keum-Shik Hong
In this paper, the use of initial dips using functional near-infrared spectroscopy (fNIRS) for brain-computer interface (BCI) is investigated. Features and window sizes for detecting initial dips are also discussed. Three mental tasks including mental arithmetic, mental counting, and puzzle solving are performed in obtaining fNIRS signals from the prefrontal cortex. Vector-based phase analysis method combined with a threshold circle, as a decision criterion, are used to detect the initial dips. Eight healthy subjects participate in experiment...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28100500/mononuclear-phagocyte-subpopulations-in-the-mouse-kidney
#7
James George, Jeremie M Lever, Anupam Agarwal
Mononuclear phagocytes are the most common cells in the kidney associated with immunity and inflammation. While the presence of these cells in the kidney has been known for decades, the study of mononuclear phagocytes in the context of kidney function and dysfunction is still at an early stage. The purpose of this review is to summarize the current knowledge regarding classification of these cell in the mouse kidney and to identify relevant questions that would further advance the field and potentially lead to new opportunities for treatment of acute kidney injury and other kidney diseases...
January 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28100099/a-user-centered-qualitative-study-on-experiences-with-ankle-foot-orthoses-and-suggestions-for-improved-design
#8
Dymphy van der Wilk, Juha Markus Hijmans, Klaas Postema, Gijsbertus Jacob Verkerke
BACKGROUND: Improving ankle-foot orthosis design can best be done by implementing a user-centered approach. OBJECTIVE: To provide insight into the ideas of ankle-foot orthosis users with flaccid ankle muscle paresis on the importance of activities and suggestions for an improved ankle-foot orthosis design. STUDY DESIGN: A focus-group discussion with eight ankle-foot orthosis users (57 ± 5 years, 50% female). METHODS: Main inclusion criteria were as follows: ⩾18 years, unable to stand on tip-toe and unable to lift toes...
January 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28099405/insights-in-transplanting-complex-paediatric-renal-recipients-with-vascular-anomalies
#9
Pankaj Chandak, Nicos Kessaris, Chris J Callaghan, Francis Calder, Jelena Stojanovic, Jonathon Olsburgh, Martin Drage, Helen Hume-Smith, Zubir Ahmed, Anna Adamusiak, Derek Roebuck, Colin Forman, Stephen D Marks, Nizam Mamode
BACKGROUND: Children with end-stage kidney disease may have co-existing iatrogenic or congenital vascular anomalies making transplantation difficult. We describe our approach in 5 recipients with vascular anomalies and significant co-morbidities, including one case of blood group incompatibility. METHODS: Five children aged 3 - 17 (median 7) years, weighing 14 - 34 (median 18) kg of whom 4 had occluded inferior vena cava or iliac veins and 2 had previous complex vascular reconstructions prior to transplantation for mid-aortic syndrome and multiple aortic aneurysms, respectively underwent renal transplantation...
January 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28099276/factors-in-the-efficacy-safety-and-impact-on-quality-of-life-for-treatment-of-drooling-with-botulinum-toxin-type-a-in-patients-with-cerebral-palsy
#10
Maria D Gonzalez-L, Carmen Martinez, Inma Bori Y Fortuny, Santiago Suso-Vergara
OBJECTIVE: To assess the efficacy and safety of botulinum toxin A (BoNT-A) injected in both submandibular and parotid versus only in parotid glands as a treatment for drooling in patients with spastic and dyskinetic cerebral palsy (CP), including an assessment of impact on quality of life (QoL) based on items from the International Classification of Functioning, Disability, and Health (ICF) core set. DESIGN: Forty patients with CP 18 years or older (mean, 21.8 years) participated in a prospective, single-center, randomized controlled interventional study...
February 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28098705/heterotopic-ossification-in-acetabular-fracture-surgery
#11
Reza Firoozabadi, Timothy Alton, Henry Claude Sagi
Heterotopic ossification (HO) is a common complication of the surgical treatment of acetabular fractures. HO is the formation of trabecular bone in soft tissues where bone does not usually occur. Over the last decade, many risk factors have been identified for HO after surgical fixation of acetabular fractures; however, prophylaxis and treatment of this condition are controversial. Potential preventive measures range from NSAIDs to external beam irradiation, but recent studies have questioned the utility of these measures...
February 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28098335/not-an-exception-to-the-rule-the-functional-significance-of-intrinsically-disordered-protein-regions-in-enzymes
#12
Shelly DeForte, Vladimir N Uversky
Intrinsically disordered protein regions (IDPRs) are remarkably common and have unique and important biological functions. Enzymes have long been considered an exception to the rule of protein intrinsic disorder due to the structural requirements for catalysis. Although functionally significant IDPRs have been described in several enzymes, there has been no study quantifying the extent of this phenomenon. We have conducted a multilevel computational analysis of missing regions in X-ray crystal structures in the PDB and predicted disorder in 66 representative proteomes...
January 18, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28097693/distinguishing-between-biochemical-and-cellular-function-are-there-peptide-signatures-for-cellular-function-of-proteins
#13
Shruti Jain, Kausik Bhattacharyya, Rachit Bakshi, Ankita Narang, Vani Brahmachari
The genome annotation and identification of gene function depends on conserved biochemical activity. However, in the cell, proteins with the same biochemical function can participate in different cellular pathways and cannot complement one another. Similarly, two proteins of very different biochemical functions are put in the same class of cellular function; for example, the classification of a gene as an oncogene or a tumour suppressor gene is not related to its biochemical function, but is related to its cellular function...
January 18, 2017: Proteins
https://www.readbyqxmd.com/read/28097324/molecular-based-recursive-partitioning-analysis-model-for-glioblastoma-in-the-temozolomide-era-a-correlative-analysis-based-on-nrg-oncology-rtog-0525
#14
Erica Hlavin Bell, Stephanie L Pugh, Joseph P McElroy, Mark R Gilbert, Minesh Mehta, Alexander C Klimowicz, Anthony Magliocco, Markus Bredel, Pierre Robe, Anca-L Grosu, Roger Stupp, Walter Curran, Aline P Becker, Andrea L Salavaggione, Jill S Barnholtz-Sloan, Kenneth Aldape, Deborah T Blumenthal, Paul D Brown, Jon Glass, Luis Souhami, R Jeffrey Lee, David Brachman, John Flickinger, Minhee Won, Arnab Chakravarti
Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Objective: To refine the existing clinically based recursive partitioning analysis (RPA) model by incorporating molecular variables. Design, Setting, and Participants: NRG Oncology RTOG 0525 specimens (n = 452) were analyzed for protein biomarkers representing key pathways in GBM by a quantitative molecular microscopy-based approach with semiquantitative immunohistochemical validation...
January 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28095989/prolonged-k-deficiency-increases-intracellular-atp-cell-cycle-arrest-and-cell-death-in-renal-tubular-cells
#15
Kedsarin Fong-Ngern, Nardtaya Ausakunpipat, Nilubon Singhto, Kanyarat Sueksakit, Visith Thongboonkerd
BACKGROUND: Chronic potassium (K(+)) deficiency can cause renal damage namely hypokalemic nephropathy with unclear pathogenic mechanisms. In the present study, we investigated expression and functional alterations in renal tubular cells induced by prolonged K(+) deficiency. METHODS: MDCK cells were maintained in normal-K(+) (CNK) (K(+)=5.3mmol/L), low-K(+) (CLK) (K(+)=2.5mmol/L), or K(+)-depleted (CKD) (K(+)=0mmol/L) medium for 10days (n=5 independent cultures/condition)...
January 4, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28095819/adhd-comorbid-disorders-and-psychosocial-functioning-how-representative-is-a-child-cohort-study-findings-from-a-national-patient-registry
#16
Beate Oerbeck, Kristin Romvig Overgaard, Stian Thoresen Aspenes, Are Hugo Pripp, Marianne Mordre, Heidi Aase, Ted Reichborn-Kjennerud, Pal Zeiner
BACKGROUND: Cohort studies often report findings on children with Attention Deficit Hyperactivity Disorder (ADHD) but may be biased by self-selection. The representativeness of cohort studies needs to be investigated to determine whether their findings can be generalised to the general child population. The aim of the present study was to examine the representativeness of child ADHD in the Norwegian Mother and Child Cohort Study (MoBa). METHODS: The study population was children born between January 1, 2000 and December 31, 2008 registered with hyperkinetic disorders (hereafter ADHD) in the Norwegian Patient Registry during the years 2008-2013, and two groups of children with ADHD were identified in: 1...
January 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28095735/criterion-validity-of-the-d-kefs-color-word-and-verbal-fluency-switching-paradigms-following-traumatic-brain-injury
#17
Luke B Anderson, Rebekah Jaroh, Hillary Smith, Carrie-Ann H Strong, Jacobus Donders
The present study was composed of two parts examining the clinical utility of the Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency and Color-Word subtests in traumatic brain injury (TBI). In the first part, the performance of 128 outpatients with mild to severe TBI on the Verbal Fluency and Color-Word subtests was examined in relation to two primary indicators of TBI severity: length of coma and the presence of intracranial lesions on neuroimaging through regression analysis. After controlling for education, ethnicity, and complicating premorbid and comorbid factors, length of coma predicted performance on the Color-Word Inhibition/Switching subtest, whereas the presence of diffuse lesions was related to Verbal Fluency Category Switching performance...
January 17, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28095660/draft-genome-of-toxocara-canis-a-pathogen-responsible-for-visceral-larva-migrans
#18
Jinhwa Kong, Jungim Won, Jeehee Yoon, UnJoo Lee, Jong-Il Kim, Sun Huh
This study aimed at constructing a draft genome of the adult female worm Toxocara canis using next-generation sequencing (NGS) and de novo assembly, as well as to find new genes after annotation using functional genomics tools. Using an NGS machine, we produced DNA read data of T. canis. The de novo assembly of the read data was performed using SOAPdenovo. RNA read data were assembled using Trinity. Structural annotation, homology search, functional annotation, classification of protein domains, and KEGG pathway analysis were carried out...
December 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28095197/solving-nonlinearly-separable-classifications-in-a-single-layer-neural-network
#19
Nolan Conaway, Kenneth J Kurtz
Since the work of Minsky and Papert (1969), it has been understood that single-layer neural networks cannot solve nonlinearly separable classifications (i.e., XOR). We describe and test a novel divergent autoassociative architecture capable of solving nonlinearly separable classifications with a single layer of weights. The proposed network consists of class-specific linear autoassociators. The power of the model comes from treating classification problems as within-class feature prediction rather than directly optimizing a discriminant function...
January 17, 2017: Neural Computation
https://www.readbyqxmd.com/read/28094881/children-with-motor-impairment-related-to-cerebral-palsy-prevalence-severity-and-concurrent-impairments-in-china
#20
Ping He, Gong Chen, Zhenjie Wang, Chao Guo, Xiaoying Zheng
AIM: Cerebral palsy (CP) is the most common cause of motor impairment in childhood. This study aimed to examine the prevalence, severity and concurrent impairments of CP-related motor impairment among Chinese children. METHODS: Children with CP-related motor impairment aged 0-17 years were identified through a national population-based survey based on World Health Organization International Classification of Functioning, Disability and Health. Logistic regression models allowing for weights were used to examine individual and family factors in relation to CP-related motor impairment...
January 17, 2017: Journal of Paediatrics and Child Health
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