Francisca Bertin, Guillermo Moya-Alvarado, Eduardo Quiroz-Manríquez, Andrés Ibacache, Andrés Köhler-Solis, Carlos Oliva, Jimena Sierralta
The vertebrates' scaffold proteins of the Dlg-MAGUK family are involved in the recruitment, clustering, and anchoring of glutamate receptors to the postsynaptic density, particularly the NMDA subtype glutamate-receptors (NRs), necessary for long-term memory and LTP. In Drosophila , the only gene of the subfamily generates two main products, dlgA , broadly expressed, and dlgS97 , restricted to the nervous system. In the Drosophila brain, NRs are expressed in the adult brain and are involved in memory, however, the role of Dlg in these processes and its relationship with NRs has been scarcely explored...
August 16, 2022: International Journal of Molecular Sciences