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Ivan Andreevich Yaremenko, Gabriel Dos Passos Gomes, Peter Sergeevich Radulov, Yulia Yur'evna Belyakova, Anatoliy Evgen'evich Vilikotskiy, Vera Andreevna Vil', Alexander A Korlyukov, Gennady Ivanovich Nikishin, Igor V Alabugin, Alexander Olegovich Terent'ev
Reactions of 1,5-diketones with H2O2 open an ozone-free approach to ozonides. Bridged ozonides are formed readily at the room temperature in the presence of strong Brønsted or Lewis acids such as H2SO4, p-TsOH, HBF4, or BF3•Et2O. The expected bridged tetraoxanes, the products of double H2O2 addition, were not detected. This procedure is readily scalable to produce gram quantities of the ozonides. Bridged ozonides are stable and can be useful as building block for bioconjugation and further synthetic transformations...
March 13, 2018: Journal of Organic Chemistry
Marianne Goudreault, Nago Humbert, France Gauvin, Monia Marzouki, Catherine K Beaumier, Dickens St-Vil, Nelson Piché
INTRODUCTION: Pediatric surgeons are often involved in the management of severely or terminally ill patients. However, articles addressing their specific roles in the context of palliative care are almost inexistent. We sought to characterize the involvement of pediatric surgeons caring for children near end of life. METHODS: Chart review of children who had a procedure under general anesthesia within 6months of their death over a five-year period at a tertiary children's hospital (excluding traumas and neonatology cases)...
February 9, 2018: Journal of Pediatric Surgery
Robin Holtedahl
BAKGRUNN: Knesmerter er blant de vanligste årsaker til konsultasjoner for muskel- og skjelettplager. Siktemålet med denne artikkelen er dels å gi en oversikt over de siste par tiårs forskning på atraumatiske og degenerativt betingede kneplager, dels å vurdere hvorvidt den sedvanlige praksis for utredning og behandling er i samsvar med denne forskningen. KUNNSKAPSGRUNNLAG: Artikkelen er basert på et utvalg av engelskspråklige studier av atraumatiske og degenerative knelidelser funnet ved søk i Medline, manuelle søk i artiklenes litteraturlister og litteraturforslag fra Mendeley...
March 6, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Isabelle Hardy, Steven R McFaull, Marianne Beaudin, Dickens St-Vil, Élizabeth Rousseau
Introduction: Cheerleading has gradually become more popular in Canada and represents an accessible way for youth to be physically active. Objective: To determine the differences in the injuries encountered by cheerleaders according to their age, in order to propose safety guidelines that take into account the developmental stages of children. Method: Retrospective database review of cheerleading injuries extracted from the Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP) database between 1990 and 2010...
June 2017: Paediatrics & Child Health
Morten Tryland, Kimberlee Beth Beckmen, Kathleen Ann Burek-Huntington, Eva Marie Breines, Joern Klein
BACKGROUND: The zoonotic Orf virus (ORFV; genus Parapoxvirus, Poxviridae family) occurs worldwide and is transmitted between sheep and goats, wildlife and man. Archived tissue samples from 16 Alaskan wildlife cases, representing mountain goat (Oreamnos americanus, n = 8), Dall's sheep (Ovis dalli dalli, n = 3), muskox (Ovibos moschatus, n = 3), Sitka black-tailed deer (Odocoileus hemionus sitkensis, n = 1) and caribou (Rangifer tarandus granti, n = 1), were analyzed. RESULTS: Clinical signs and pathology were most severe in mountain goats, affecting most mucocutaneous regions, including palpebrae, nares, lips, anus, prepuce or vulva, as well as coronary bands...
February 21, 2018: Acta Veterinaria Scandinavica
Vera Vil', Gabriel Dos Passos Gomes, Oleg Bityukov, Konstantin Lyssenko, Gennady Nikishin, Igor Alabugin, Alexander Terent'ev
The instability of hydroxyl peroxyesters, the elusive Criegee intermediates of the Bayer-Villiger rearrangement, can be alleviated by selective deactivation of stereoelectronic effects that promote the 1,2-alkyl shift. Stable cyclic Criegee intermediates constrained within a five-membered ring can be prepared by mild reduction of respective hydroperoxyl peroxyesters (β-hydroperoxy-β-peroxylactones) which were formed in high yields in reaction of β-ketoesters with BF3·Et2O/H2O2.
January 31, 2018: Angewandte Chemie
Virginie Bussières, Shreyas Roy, Johnny Deladoey, Élisabeth Rousseau, Dickens St-Vil, Nelson Piché
AIM OF THE STUDY: The aim of the study was to evaluate the outcomes of prophylactic thyroidectomies performed in an academic setting in the context of multiple endocrine neoplasia type 2 (MEN2) syndrome. METHODS: A chart review of patients <18years old who underwent prophylactic thyroidectomy for a MEN2 syndrome at a children's hospital between 2006 and 2015 was performed. MAIN RESULTS: The study included 21 patients (57% female) with a mean age of 6...
November 13, 2017: Journal of Pediatric Surgery
Vera A Vil', Ivan A Yaremenko, Alexey I Ilovaisky, Alexander O Terent'ev
The biological activity of organic peroxides is usually associated with the antimalarial properties of artemisinin and its derivatives. However, the analysis of published data indicates that organic peroxides exhibit a variety of biological activity, which is still being given insufficient attention. In the present review, we deal with natural, semi-synthetic and synthetic peroxides exhibiting anthelmintic, antiprotozoal, fungicidal, antiviral and other activities that have not been described in detail earlier...
November 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Kamila A Alexander, Noelle M St Vil, Marilyn A Braithwaite-Hall, Michael Sanchez, Aletha Baumann, Gloria B Callwood, Jacquelyn C Campbell, Doris W Campbell
OBJECTIVES: Global evidence suggests that individuals who experience intimate partner violence (IPV) can have accelerated risk for HIV transmission. The U.S. Virgin Islands (USVI) has high per capita rates of HIV and IPV that can have devastating effects on women's health. Catalysts for these health disparities may be shaped by cultural and social definitions of conventional masculinity. Thus, understanding USVI men's perceptions about HIV risks and IPV are a necessary component of developing strategies to improve women's health...
October 31, 2017: Ethnicity & Health
Zhuan-Fen Cheng, Christine A Cartwright
Previously we generated mouse models of Rack1 deficiency to identify key functions for Rack1 in regulating growth of intestinal epithelia: suppressing crypt cell proliferation and regeneration, promoting differentiation and apoptosis, and repressing development of neoplasia. However, other than low body weight, we did not detect an overt phenotype in mice constitutively deleted of Rack1 in intestinal epithelia (vil-Cre:Rack1(fl/fl) mice), presumably because Rack1 was deleted in < 10% of the total surface area of the epithelia...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
Denis E O'Donnell, Amany F Elbehairy, Azmy Faisal, J Alberto Neder, Katherine A Webb
This randomized, double-blind, crossover study examined the physiological rationale for using a dual long-acting bronchodilator (umeclidinium/vilanterol (UME/VIL)) versus its muscarinic-antagonist component (UME) as treatment for dyspnea and exercise intolerance in moderate COPD. After each 4-week treatment period, subjects performed pulmonary function and symptom-limited constant-work rate cycling tests with diaphragm electromyogram (EMGdi), esophageal (Pes), gastric (Pga) and transdiaphragmatic (Pdi) pressure measurements...
October 7, 2017: Respiratory Physiology & Neurobiology
Ravit Linn, Yotam Tepper, Guy Bar-Oz
The Transfiguration scene depicted in a Byzantine church at Shivta, Israel, is one of two figurative examples of the scene from the early Christian period. The use of Egyptian blue pigment in the wall painting was investigated with various analytical methods. Visible Induced Luminescence (VIL) imaging was used in-situ in order to map the distribution of the Egyptian blue pigment in the painting. The VIL imaging revealed surprising insights into the understanding of the iconography and the technology of this rare painting...
2017: PloS One
James González, Geovani López, Stefany Argueta, Ximena Escalera-Fanjul, Mohammed El Hafidi, Carlos Campero-Basaldua, Joseph Strauss, Lina Riego-Ruiz, Alicia González
Saccharomyces cerevisiae harbors BAT1 and BAT2 paralogous genes that encode branched chain aminotransferases and have opposed expression profiles and physiological roles . Accordingly, in primary nitrogen sources such as glutamine, BAT1 expression is induced, supporting Bat1-dependent valine-isoleucine-leucine (VIL) biosynthesis, while BAT2 expression is repressed. Conversely, in the presence of VIL as the sole nitrogen source, BAT1 expression is hindered while that of BAT2 is activated, resulting in Bat2-dependent VIL catabolism...
November 2017: Genetics
Aleidis Skard Brandrud, Bjørnar Nyen, Per Hjortdahl, Leiv Sandvik, Gro Sævil Helljesen Haldorsen, Maria Bergli, Eugene C Nelson, Michael Bretthauer
BACKGROUND: There is a distinct difference between what we know and what we do in healthcare: a gap that is impairing the quality of the care and increasing the costs. Quality improvement efforts have been made worldwide by learning collaboratives, based on recognized continual improvement theory with limited scientific evidence. The present study of 132 quality improvement projects in Norway explores the conditions for improvement from the perspectives of the frontline healthcare professionals, and evaluates the effectiveness of the continual improvement method...
September 13, 2017: BMC Health Services Research
Daming Chen, Qiwang Xiang, John Nicholas
Viral interleukin-6 (vIL-6) encoded by human herpesvirus 8 (HHV-8) is believed to contribute via mitogenic, survival, and angiogenic activities to HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease through autocrine or paracrine mechanisms during latency or productive replication. There is direct evidence that vIL-6 promotes latently infected PEL cell viability and proliferation and also viral productive replication in PEL and endothelial cells. These activities are mediated largely through endoplasmic reticulum (ER)-localized vIL-6, which can induce signal transduction via the gp130 signaling receptor, activating mitogen-activated protein kinase and signal transducer and activator of transcription signaling, and interactions of vIL-6 with the ER membrane protein vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2)...
November 15, 2017: Journal of Virology
Ambre Riba, Maïwenn Olier, Sonia Lacroix-Lamandé, Corinne Lencina, Valérie Bacquié, Cherryl Harkat, Marion Gillet, Marine Baron, Caroline Sommer, Virginie Mallet, Christel Salvador-Cartier, Fabrice Laurent, Vassilia Théodorou, Sandrine Ménard
BACKGROUND & AIMS: Separation of newborn rats from their mothers induces visceral hypersensitivity and impaired epithelial secretory cell lineages when they are adults. Little is known about the mechanisms by which maternal separation causes visceral hypersensitivity or its relationship with defects in epithelial secretory cell lineages. METHODS: We performed studies with C3H/HeN mice separated from their mothers as newborns and mice genetically engineered (Sox9flox/flox -vil-cre on C57BL/6 background) to have deficiencies in Paneth cells...
December 2017: Gastroenterology
Lauren M Postlewait, Clara R Farley, Maggie L Diller, Benjamin Martin, M Hart Squires, Maria C Russell, Monica Rizzo, Kenneth Ogan, Viraj Master, Keith Delman
BACKGROUND: Open inguinal lymphadenectomy (OIL) has a high incidence of complications. The authors adapted and reported a minimally invasive technique [videoscopic inguinal lymphadenectomy (VIL)] for use with melanoma, subsequently pursuing a randomized, prospective trial comparing open and minimally invasive approaches in an attempt to confirm retrospective findings illustrating reduced complications with the minimally invasive approach. METHODS: A randomized, prospective trial (NCT01526486) was designed to compare outcomes for patients undergoing VIL versus OIL...
October 2017: Annals of Surgical Oncology
Hoda A Abd-Ellatieff, Abdelrahman A Abou Rawash, Hany F Ellakany, Wael M Goda, T Suzuki, Tokuma Yanai
Marek's disease (MD) is a lymphoproliferative disease causing a serious threat in poultry production. Field strains of Marek's disease virus (MDVs) are continuously re-emerging, causing great economical losses to the poultry industry worldwide in spite of the intensive vaccination and restrictive management policy used. Histopathological and molecular characterizations of MDVs are essential for monitoring the changes of viruses and evaluating the effectiveness of existing vaccines. During 2016, 190 visceral tumor tissues representing 30 vaccinated chicken flocks from Gifu prefecture, Japan were analyzed...
August 1, 2017: Avian Pathology: Journal of the W.V.P.A
Joery Goossens, Maria Bjerke, Hanne Struyfs, Ellis Niemantsverdriet, Charisse Somers, Tobi Van den Bossche, Sara Van Mossevelde, Bart De Vil, Anne Sieben, Jean-Jacques Martin, Patrick Cras, Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven, Julie van der Zee, Sebastiaan Engelborghs
BACKGROUND: The Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau, and p-tau181 overlap with other diseases. New tau modifications or epitopes, such as the non-phosphorylated tau fraction (p-taurel), may improve differential dementia diagnosis. The goal of this study is to investigate if p-taurel can improve the diagnostic performance of the AD CSF biomarker panel for differential dementia diagnosis. METHODS: The study population consisted of 45 AD, 45 frontotemporal lobar degeneration (FTLD), 45 dementia with Lewy bodies (DLB), and 21 Creutzfeldt-Jakob disease (CJD) patients, and 20 cognitively healthy controls...
July 14, 2017: Alzheimer's Research & Therapy
Guo-Rong Sun, Yan-Ping Zhang, Lin-Yi Zhou, Hong-Chao Lv, Feng Zhang, Kai Li, Yu-Long Gao, Xiao-Le Qi, Hong-Yu Cui, Yong-Qiang Wang, Li Gao, Qing Pan, Xiao-Mei Wang, Chang-Jun Liu
Marek's disease virus (MDV) and reticuloendotheliosis virus (REV) cause Marek's disease (MD) and reticuloendotheliosis (RE), respectively. Co-infection with MDV and REV is common in chickens, causing serious losses to the poultry industry. However, experimental studies of such co-infection are lacking. In this study, Chinese field strains of MDV (ZW/15) and REV (JLR1501) were used as challenge viruses to evaluate the pathogenicity of co-infection and the influence of MD vaccination in chickens. Compared to the MDV-challenged group, the mortality and tumor rates increased significantly by 20...
June 21, 2017: Viruses
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