keyword
https://read.qxmd.com/read/38513687/simulation-based-education-in-ultrasound-diagnostic-and-interventional-abdominal-focus
#1
JOURNAL ARTICLE
Malene Roland Vils Pedersen, Mia Louise Østergaard, Leizl Joy Nayahangan, Kristina Rue Nielsen, Claudia Lucius, Christoph F Dietrich, Michael Bachmann Nielsen
Simulation-based training (SBT) is increasingly acknowledged worldwide and has become a popular tool for ultrasound education. Ultrasound simulation involves the use of technology and software to create a virtual training setting. Simulation-based training allows healthcare professionals to learn, practice, and improve their ultrasound imaging skills in a safe learning-based environment. SBT can provide a realistic and focused learning experience that creates a deep and immersive understanding of the complexity of ultrasound, including enhancing knowledge and confidence in specific areas of interest...
March 21, 2024: Ultraschall in der Medizin
https://read.qxmd.com/read/38470932/kshv-vil-6-promotes-sirt3-induced-deacetylation-of-serbp1-to-inhibit-ferroptosis-and-enhance-cellular-transformation-by-inducing-lipoyltransferase-2-mrna-degradation
#2
JOURNAL ARTICLE
Jing Zhou, Tianjiao Wang, Haoran Zhang, Jianhong Liu, Pengjun Wei, Ruoqi Xu, Qin Yan, Guochun Chen, Wan Li, Shou-Jiang Gao, Chun Lu
Ferroptosis, a defensive strategy commonly employed by the host cells to restrict pathogenic infections, has been implicated in the development and therapeutic responses of various types of cancer. However, the role of ferroptosis in oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV)-induced cancers remains elusive. While a growing number of non-histone proteins have been identified as acetylation targets, the functions of these modifications have yet to be revealed. Here, we show KSHV reprogramming of host acetylation proteomics following cellular transformation of rat primary mesenchymal precursor...
March 12, 2024: PLoS Pathogens
https://read.qxmd.com/read/38428195/ultrasound-education-across-european-federation-of-radiographers-societies-efrs-countries-similarities-and-differences
#3
JOURNAL ARTICLE
B Kraus, G Harrison, R Santos, M R Vils Pedersen
INTRODUCTION: Ultrasound education varies greatly across European healthcare systems. This paper focuses on ultrasound academic education as a part of wider suite of surveys on radiographers working in ultrasound. The aim was to investigate sonography educational levels, methods of training, course duration and other factors in European Federation of Radiographers Societies (EFRS) member countries. METHOD: In 2019 an online survey was sent to the 38 EFRS member societies to distribute to higher education institutions within their own country...
February 29, 2024: Radiography
https://read.qxmd.com/read/38417977/centring-the-health-of-women-across-the-hiv-research-continuum
#4
REVIEW
Elizabeth Barr, Leslie J Marshall, Lauren F Collins, Catherine Godfrey, Noelle St Vil, Jamila K Stockman, Dvora L Joseph Davey, Krista Dong, Sarah M Temkin, Mary T Glenshaw, Corette Byrd, Janine A Clayton, Maureen M Goodenow
Despite tremendous advances in HIV research, women and gender diverse people-particularly women from racial and ethnic groups under-represented in research, transgender women, and young women-remain disproportionately affected by HIV. Women and gender diverse people face unique challenges and have been under-represented in HIV research. The National Institutes of Health (NIH) is tasked to apply fundamental knowledge about the nature and behaviour of living systems to enhance health, lengthen life, and reduce disability...
March 2024: Lancet HIV
https://read.qxmd.com/read/38407829/edman-degradation-reveals-unequivocal-analysis-of-the-disulfide-connectivity-in-peptides-and-proteins
#5
JOURNAL ARTICLE
Yomnah Y Elsayed, Toni Kühl, Diana Imhof
Disulfide bridges in peptides and proteins play an essential role in maintaining their conformation, structural integrity, and consequently function. Despite ongoing efforts, it is still not possible to detect disulfide bonds and the connectivity of multiply bridged peptides directly through a simple and sufficiently validated protein sequencing or peptide mapping method. Partial or complete reduction and chemical cysteine modification are required as initial steps, followed by the application of a proper detection method...
February 26, 2024: Analytical Chemistry
https://read.qxmd.com/read/38365512/gene-ex-vivo-transduction-effects-on-flap-survival-and-micrornas-expression-analysis-in-rat-allotransplantation-model
#6
JOURNAL ARTICLE
Yeonjin Jeong, Se Yeon Lee, Seok Kyung In, Miso Choi, Seokchan Eun
BACKGROUND: The lack of noninvasive biomarkers for graft rejection remains a challenge for the accurate monitoring of vascularized composite allotransplants. Viral vector-mediated gene transfer is a promising method for preventing graft rejection. In this study, we aimed to establish the expression profile of microRNAs (miRNAs) in skin flap allotransplantation, with or without gene transfer, and determine the potential role of several miRNAs as biomarkers of acute rejection and immune tolerance...
February 15, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38357301/disponibilit%C3%A3-de-l-information-m%C3%A3-dicale-requise-pour-la-d%C3%A3-claration-d-une-r%C3%A3-action-ind%C3%A3-sirable-m%C3%A3-dicamenteuse-%C3%A3-sant%C3%A3-canada-une-%C3%A3-tude-exploratoire
#7
JOURNAL ARTICLE
Laurent Saint-Vil, Thaïna-Rafi Jean-Baptiste, Nicolas Martel-Côté, Denis Lebel, Jean-François Bussières
BACKGROUND: Since 2019, health care facilities have been required to report serious adverse drug reactions (ADRs) to Health Canada. OBJECTIVES: To describe the availability of information required for reporting an ADR to Health Canada from medical records using 2 methods (systematic and in-depth reporting) and to compare the time required to find the information. METHODS: This retrospective and prospective descriptive study involved serious ADRs occurring in a mother-child centre and reported between April 1, 2021, and March 31, 2023...
2024: Canadian Journal of Hospital Pharmacy
https://read.qxmd.com/read/38350713/copper-single-atoms-chelated-on-ligand-modified-carbon-for-ullmann-type-c-o-coupling
#8
JOURNAL ARTICLE
Vincenzo Ruta, Giovanni Di Liberto, Francesco Moriggi, Yurii P Ivanov, Giorgio Divitini, Gianlorenzo Bussetti, Vincenzina Barbera, Mark A Bajada, Maurizio Galimberti, Gianfranco Pacchioni, Gianvito Vilé
Invited for this month's cover is the group of Gianvito Vilé at the Politecnico di Milano. The ChemSusChem cover image depicts in an artistic manner the concept of ligand entrapping of isolated metals to design single-atom catalysts. The Research Article itself is available at 10.1002/cssc.202301529.
February 13, 2024: ChemSusChem
https://read.qxmd.com/read/38347308/association-of-client-and-provider-race-with-approaches-pursued-by-social-workers-for-reducing-firearm-access
#9
JOURNAL ARTICLE
Kelsey M Conrick, Olivia McCollum, Sarah F Porter, Christopher St Vil, Kalei Kanuha, Ali Rowhani-Rahbar, Megan Moore
Social workers assess and intervene to prevent harm among clients at risk of harm to self (HTS) and harm to others (HTO) with a firearm. This study sought to assess the impact of client race on social workers' approaches to reduce firearm access when they weighed voluntary (e.g., store out-of-home) and involuntary (e.g., extreme risk protection order) removal methods. We considered the role of social workers' self-identified race as a moderator of this relationship, comparing white (single race) and Black, Indigenous, and People of Color (BIPOC) social workers...
February 12, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38311904/protect-and-provide-perceptions-of-manhood-and-masculinities-among-disabled-violently-injured-black-men-in-a-hospital-based-violence-intervention-program
#10
JOURNAL ARTICLE
Nazsa S Baker, Cortney VanHook, Tiffany Ricks, Christopher St Vil, Teri Lassiter, Stephanie Bonne
Exploring the post-injury lives of those who have survived gunshot wounds is essential to understanding the entire scope of firearm violence. The lives of Black male firearm violence survivors are transformed in various ways due to their injuries both visible and invisible. This study explored how Black men who suffer from disabilities via a firearm negotiated their masculine identities. Semi-structured, qualitative interviews were conducted with 10 violently injured Black men participating in a hospital-based violence intervention program...
2024: American Journal of Men's Health
https://read.qxmd.com/read/38242935/prevalence-and-distribution-of-varroa-destructor-and-nosema-spp-in-symptomatic-honey-bee-colonies-across-the-usa-from-2015-to-2022
#11
JOURNAL ARTICLE
Samuel Abban, Bart Smith, Miguel Corona, Steven C Cook, Jay D Evans, Yanping Chen, Mohamed Alburaki
USDA-ARS Bee Research Laboratory received symptomatic honey bee (Apis mellifera L.) samples across the United States for disease diagnosis. Here, we present a retrospective study and cartography of ectoparasite Varroa destructor and intracellular microsporidia parasite Nosema spp. These two major parasites were identified in the diseased honey bee samples between 2015 and 2022. Varroa infestation level (VIL) was examined by a wash technique (Mites/100 bees) and calculated as a percentage, while Nosema infection was quantified by microscopical spore count (Million Spores/Bee)...
January 19, 2024: Scientific Reports
https://read.qxmd.com/read/38201571/diffusion-weighted-mri-as-a-quantitative-imaging-biomarker-in-colon-tumors
#12
JOURNAL ARTICLE
Peter Obel Otto, Martina Kastrup Loft, Søren Rafael Rafaelsen, Malene Roland Vils Pedersen
PURPOSE: To assess the use of quantitative diffusion-weighted MRI (DW-MRI) as a diagnostic imaging biomarker in differentiating between benign colon adenoma, early, and advanced cancer of the colon, as well as predicting lymph node involvement, and finally comparing mucinous-producing colon cancer with adenomas and non-mucinous colon cancer. METHOD: Patients with a confirmed tumor on colonoscopy were eligible for inclusion in this study. Using a 3.0 Tesla MRI machine, the main tumor mean apparent diffusion coefficient (mADC) was obtained...
December 27, 2023: Cancers
https://read.qxmd.com/read/38169005/just-my-luck-how-children-s-causal-attributions-contribute-to-injury-prevention
#13
JOURNAL ARTICLE
Pavel Zhuravlev, Claudia Mueller, Dickens St Vil
PURPOSE: Traumatic injury in children, particularly adolescents, is both frequently and costly. In this study, we directly examined children's causal attributions for the recent traumas and asked them to propose prevention strategies of their own. We predict that children who attribute their injuries to their own actions, rather than an external force such as luck, will be more likely to develop strategies to avoid trauma in the future. METHODS: All children aged 10 -18 years who presented to a Level 1 pediatric trauma center at an urban children's hospital over a ten-month period were identified and presented with a series of structured interview questions...
January 2, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38153332/electrochemical-generation-of-peroxy-radicals-and-subsequent-peroxidation-of-1-3-dicarbonyls-in-an-undivided-cell
#14
JOURNAL ARTICLE
Oleg V Bityukov, Ksenia V Skokova, Vera A Vil', Gennady I Nikishin, Alexander O Terent'ev
The generation of peroxy radicals from hydroperoxides with subsequent selective peroxidation of 1,3-dicarbonyls in an undivided electrochemical cell under constant current conditions is reported. The method provides a variety of peroxy-containing barbituric acids and 4-hydroxy-2(5 H )-furanones with yields of up to 74%. Only the combination of anodic and cathodic processes provides efficient peroxidation by generating a set of alkoxy and peroxy radicals. NaNO3 acts as both an electrolyte and a redox mediator of radical reactions...
December 28, 2023: Organic Letters
https://read.qxmd.com/read/38076659/vil-cre-specific-slfn3ko-mice-exhibit-sex-specific-differences-in-lung-stomach-cecum-kidney-and-proximal-colon-differentiation-markers-and-slfn-family-members-expression-levels
#15
JOURNAL ARTICLE
Emilie E Vomhof-DeKrey, Odele K Rajpathy, Elizabeth Preszler, Marc D Basson
The Schlafen (Slfn) family proteins are critical regulators of cell proliferation, induction of immune responses, differentiation, self-restoration, and cell cycle progression. Rodent Slfn3 and human ortholog SLFN12 are critical in the regulation of intestinal epithelial differentiation. Following previous work utilizing Vil-Cre epithelial-specific Slfn3 knockout (VC-Slfn3KO) mice to evaluate Slfn3's role in small intestinal epithelial differentiation, we sought to characterize and distinguish the effects of Slfn3 loss on Slfn family member mRNA expression and differentiation markers for other epithelial cells in the lung, stomach, cecum, and proximal colon...
December 2023: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38046601/phd-finger-proteins-function-in-plant-development-and-abiotic-stress-responses-an-overview
#16
REVIEW
Wenli Quan, Zhulong Chan, Piwei Wei, Yahui Mao, Dorothea Bartels, Xun Liu
The plant homeodomain (PHD) finger with a conserved Cys4-His-Cys3 motif is a common zinc-binding domain, which is widely present in all eukaryotic genomes. The PHD finger is the "reader" domain of methylation marks in histone H3 and plays a role in the regulation of gene expression patterns. Numerous proteins containing the PHD finger have been found in plants. In this review, we summarize the functional studies on PHD finger proteins in plant growth and development and responses to abiotic stresses in recent years...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/38032704/intestinal-ffa2-promotes-obesity-by-altering-food-intake-in-western-diet-fed-mice
#17
JOURNAL ARTICLE
Kristen R Lednovich, Sophie Gough, Medha Priyadarshini, Nupur Pandya, Chioma Nnyamah, Kai Xu, Barton Wicksteed, Sidharth Mishra, Shalini Jain, Joseph L Zapater, Jose Cordoba-Chacon, Hariom Yadav, Brian Layden
Short-chain fatty acids (SCFAs) are key nutrients that play a diverse set of roles in physiological function, including regulating metabolic homeostasis. Generated through the fermentation of dietary fibers in the distal colon by the gut microbiome, SCFAs and their effects are partially mediated by their cognate receptors, including free fatty acid receptor 2 (FFA2). FFA2 is highly expressed in the intestinal epithelial, where its putative functions are controversial, with numerous in vivo studies relying on global knockout mouse models to characterize intestine-specific roles of the receptor...
November 1, 2023: Journal of Endocrinology
https://read.qxmd.com/read/38023603/mechanism-of-action-of-natural-dipeptidyl-peptidase-iv-inhibitors-berberine-and-mangiferin-in-experimentally-induced-diabetes-with-metabolic-syndrome
#18
JOURNAL ARTICLE
Rajesh Kumar Suman, Manjusha K Borde, Ipseeta Ray Mohanty, Hemant Kumar Singh
BACKGROUND: Berberine (BER) and mangiferin are known natural dipeptidyl peptidase (DPP-IV) inhibitors. Hence, the study was designed to elucidate the mechanism of action of natural DPP-IV inhibitors (BER and MNG) in experimentally induced diabetes with metabolic syndrome. AIM: The aim of this study was to observe mechanism through which natural DPP-IV inhibitor works in diabetes with metabolic syndrome rat model. MATERIALS AND METHODS: Wistar rats were fed high-fat diet for 10 weeks and challenged with streptozotocin (STZ) (40 mg/kg) at the 3rd week (high-fat diabetic control [HF-DC] group)...
2023: International Journal of Applied and Basic Medical Research
https://read.qxmd.com/read/38021574/real-world-observational-study-on-vildagliptin-with-insulin-vil-ins-or-vildagliptin-and-metformin-with-insulin-vil-met-ins-therapy-in-indian-patients-with-type-2-diabetes-mellitus
#19
JOURNAL ARTICLE
P Panneerselvam, Dibakar Biswas, Hema Singh, K Dilip Kumar, P Ravi Kumar, Pramila Kalra, Santosh Revankar, Sona Warrier
BACKGROUND AND OBJECTIVE:  The therapeutic use of vildagliptin and insulin (VIL-INS) or vildagliptin and metformin in combination with insulin (VIL-MET-INS) in the Indian scenario has yet to be explored by generating real-world evidence. Therefore, the present study aimed to evaluate the demographic, clinical characteristics, and treatment patterns of patients with type 2 diabetes mellitus (T2DM) in Indian settings in the above context. METHODOLOGY:  This observational study conducted at 600 healthcare centers in India retrospectively analyzed data of adult patients with T2DM who had been treated with either vildagliptin with insulin or a combination of vildagliptin and metformin with insulin...
October 2023: Curēus
https://read.qxmd.com/read/37980568/automatic-quantification-of-myocardial-remodeling-features-in-human-ventricular-tissue-from-label-free-microscopy
#20
JOURNAL ARTICLE
Laura García-Mendívil, María Pérez-Zabalza, Sam Duwé, Laura Ordovás, Esther Pueyo
The procedures used routinely for collagen and lipofuscin evaluation are, in many cases, qualitative, observer dependent, and disregard spatial distribution. Here, we present a protocol for automatic quantification and spatial characterization of collagen and lipofuscin from label-free microscopy images of human ventricular tissues. We describe the steps for sample collection, tissue processing, image acquisition, and quantification of collagen and lipofuscin. This protocol avoids discrepancies between observers and can be adapted to other tissues and species...
November 18, 2023: STAR protocols
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