Paula Fernanda Ribas Neves, Bruna Bueno Milanesi, Lisiê Valéria Paz, Valentina Aguiar Cardozo de Miranda Monteiro, Laura Tartari Neves, Louise Cordoni da Veiga, Rafaela Barboza da Silva, Juliana Henz Sulzbach, Gabriela Padilla Knijkik, Eduarda Correa de Revoredo Ribeiro, Ellen Larissa de Souza Silva, Moema Queiroz Vieira, Pamela Brambilla Bagatini, Andrea Wieck, Régis Gemerasca Mestriner, Léder Leal Xavier
Paraquat (PQ) is a widely used herbicide that can cross the dopaminergic neuronal membrane, accumulate in mitochondria and damage complex I of the electron transport chain, leading to neuronal death. In Drosophila melanogaster, PQ exposure leads to the development of parkinsonism and is a classical model for studying Parkinson's Disease (PD). Muscle mitochondrial dysfunction, affecting survival and locomotion, is described in familial PD in D. melanogaster mutants. However, no study has shown the effects of PQ-induced parkinsonism in D...
March 30, 2022: Toxicology Letters