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Calibration logistic regression

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https://www.readbyqxmd.com/read/28739383/patient-reported-intestinal-toxicity-from-whole-pelvis-intensity-modulated-radiotherapy-first-quantification-of-bowel-dose-volume-effects
#1
Carla Sini, Barbara Noris Chiorda, Pietro Gabriele, Giuseppe Sanguineti, Sara Morlino, Fabio Badenchini, Domenico Cante, Viviana Carillo, Marcella Gaetano, Tommaso Giandini, Valeria Landoni, Angelo Maggio, Lucia Perna, Edoardo Petrucci, Vincenzo Sacco, Riccardo Valdagni, Tiziana Rancati, Claudio Fiorino, Cesare Cozzarini
BACKGROUND AND PURPOSE: Intestinal toxicity is commonly experienced during whole-pelvis intensity-modulated radiotherapy (WPRT) for prostate cancer. The aim of the current study was to assess bowel dose-volume relationships for acute patient-reported intestinal symptoms of patients treated with WPRT for prostate cancer. MATERIALS AND METHODS: Complete data of 206 patients were available; the median dose to pelvic nodes was 51.8Gy (range 50.4-54.4, 1.7-2Gy/fr). Intestinal symptoms were assessed as changes in the Inflammatory Bowel Disease Questionnaire scores relative to the Bowel Domain (IBDQ-B) between baseline and radiotherapy mid-point/end...
July 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28736558/evaluation-of-the-crusade-risk-score-for-predicting-major-bleeding-in-patients-with-concomitant-kidney-dysfunction-and-acute-coronary-syndromes
#2
Marianela Sánchez-Martínez, Pedro J Flores-Blanco, Ángel A López-Cuenca, María J Sánchez-Galián, Miriam Gómez-Molina, Francisco Cambronero-Sánchez, Esther Guerrero-Pérez, Mariano Valdés, James L Januzzi, Sergio Manzano-Fernández
BACKGROUND: Kidney dysfunction (KD) has been associated with increased risk for major bleeding (MB) in patients with acute coronary syndromes (ACS) and may be in part related to an underuse of evidence-based therapies. Our aim was to assess the predictive ability of the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) risk score in patients with concomitant ACS and chronic kidney disease. METHODS: We conducted a retrospective analysis of a prospective registry including 1,587 ACS patients...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28735151/do-air-pollution-and-neighborhood-greenness-exposures-improve-the-predicted-cardiovascular-risk
#3
Maayan Yitshak-Sade, Itai Kloog, Victor Novack
BACKGROUND: Numerous studies show associations between exposure to Particulate Matter and Cardiovascular disease (CVD). Current cardiovascular equations incorporate the major risk factors for CVD. The patients' environment, however, is not incorporated in these equations. METHODS: In a retrospective analysis, we assessed the contribution of neighborhood greenness and particulate matter (coarse-PM and PM<2.5μm-PM2.5) to the development of CVD by analyzing the change in prediction abilities...
July 20, 2017: Environment International
https://www.readbyqxmd.com/read/28732643/development-and-internal-validation-of-a-prediction-model-to-estimate-the-probability-of-needing-aggressive-immunosuppressive-therapy-with-cytostatics-in-de-novo-lupus-nephritis-patients
#4
Mauricio Restrepo-Escobar, Paula Andrea Granda-Carvajal, Fabián Jaimes
OBJECTIVE: To develop a multivariable clinical prediction model for the requirement of aggressive immunosuppression with cytostatics, based on simple clinical record data and lab tests. The model is defined in accordance with the result of the kidney biopsies. METHODS: Retrospective study conducted with data from patients 16 years and older, with SLE and nephritis with less than 6 months of evolution. An initial bivariate analysis was conducted to select the variables to be included in a multiple logistic regression model...
July 18, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28717373/diagnostic-value-of-alarm-symptoms-for-upper-gi-malignancy-in-patients-referred-to-gi-clinic-a-7-years-cross-sectional-study
#5
Mohammad Hasan Emami, Masoud Ataie-Khorasgani, Nasim Jafari-Pozve
BACKGROUND: Early upper gastrointestinal (UGI) cancer detection had led to organ-preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy. This study is designed to see whether using alarm symptoms can predict the risk of cancer in patients. MATERIALS AND METHODS: A total of 3414 patients referred to a tertiary gastrointestinal (GI) clinic in Isfahan, Iran, from 2009 to 2016 with dyspepsia, gastroesophageal reflux disease (GERD), and alarm symptoms, such as weight loss, dysphagia, GI bleeding, vomiting, positive familial history for cancer, and anorexia...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28716010/risk-scores-to-predict-decreased-glomerular-filtration-rate-at-10%C3%A2-years-in-an-asian-general-population
#6
Krittika Saranburut, Prin Vathesatogkit, Nisakron Thongmung, Anchalee Chittamma, Somlak Vanavanan, Tuangrat Tangstheanphan, Piyamitr Sritara, Chagriya Kitiyakara
BACKGROUND: Asians have among the highest prevalence of chronic kidney disease (CKD) or end-stage renal disease in the world. A risk score capable of identifying high risk individuals at the primary care level could allow targeted therapy to prevent future development of CKD. Risk scores for new CKD have been developed in US general populations, but the impact of various risks factors for development of CKD may differ in Asian subjects. In this study, we aimed to develop risk models and simplified risk scores to predict the development of decreased glomerular filtration rate (GFR) at 10 years in an Asian general population using readily obtainable clinical and laboratory parameters...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28706920/obesity-among-sudanese-adults-with-diabetes-a-population-based-survey
#7
Yasmeen A Ali, Ahmed O Almobarak, Heitham Awadalla, Wadie M Elmadhoun, Mohamed H Ahmed
BACKGROUND: The aim of this study was to determine the prevalence of obesity among Sudanese individuals with diabetes. METHODS: Demographic and clinical data from 1,337 individuals with type 2 diabetes were collected using a pretested, standardized, interviewer administered questionnaire. Subjects were recruited from three states namely Khartoum, Northern and River Nile States. Anthropometric measurements including body weight, height and waist circumference were determined using standardized techniques and calibrated equipment...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28688663/comparing-traditional-and-novel-injury-scoring-systems-in-a-us-level-i-trauma-center-an-opportunity-for-improved-injury-surveillance-in%C3%A2-low-and-middle-income-countries
#8
Adam D Laytin, Rochelle A Dicker, Martin Gerdin, Nobhojit Roy, Bhakti Sarang, Vineet Kumar, Catherine Juillard
BACKGROUND: In most low- and middle-income countries (LMICs), the resources to accurately quantify injury severity using traditional injury scoring systems are limited. Novel injury scoring systems appear to have adequate discrimination for mortality in LMIC contexts, but they have not been rigorously compared where traditional injury scores can be accurately calculated. To determine whether novel injury scoring systems perform as well as traditional ones in a HIC with complete and comprehensive data collection...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28684377/a-comparison-of-the-intracerebral-hemorrhage-score-and-the-acute-physiology-and-chronic-health-evaluation-ii-score-for-30-day-mortality-prediction-in-spontaneous-intracerebral-hemorrhage
#9
Koushik Pan, Ajay Panwar, Ujjawal Roy, Bidyut K Das
BACKGROUND: The intracerebral hemorrhage (ICH) score is well established as a reliable prognostic score in ICH, whereas recently, Acute Physiology and Chronic Health Evaluation II (APACHE II) has been observed to have a better discrimination in predicting mortality in primary pontine hemorrhage. Further, physiological parameters of APACHE II have been associated with outcome in ICH. This study is the first to observe a direct comparison between APACHE II and ICH scores in predicting 30-day mortality in spontaneous intracerebral hemorrhage (SICH)...
July 3, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28679639/predicting-risk-of-serious-bacterial-infections-in-febrile-children-in-the-emergency-department
#10
Adam D Irwin, Alison Grant, Rhian Williams, Ruwanthi Kolamunnage-Dona, Richard J Drew, Stephane Paulus, Graham Jeffers, Kim Williams, Rachel Breen, Jennifer Preston, Duncan Appelbe, Christine Chesters, Paul Newland, Omnia Marzouk, Paul S McNamara, Peter J Diggle, Enitan D Carrol
BACKGROUND: Improving the diagnosis of serious bacterial infections (SBIs) in the children's emergency department is a clinical priority. Early recognition reduces morbidity and mortality, and supporting clinicians in ruling out SBIs may limit unnecessary admissions and antibiotic use. METHODS: A prospective, diagnostic accuracy study of clinical and biomarker variables in the diagnosis of SBIs (pneumonia or other SBI) in febrile children <16 years old. A diagnostic model was derived by using multinomial logistic regression and internally validated...
July 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28676311/the-seattle-spine-score-predicting-30-day-complication-risk-in-adult-spinal-deformity-surgery
#11
Quinlan D Buchlak, Vijay Yanamadala, Jean-Christophe Leveque, Alicia Edwards, Kellen Nold, Rajiv Sethi
BACKGROUND: Complication rates in complex spine surgery range from 25% to 80% in published studies. Numerous studies have shown that surgeons are not able to accurately predict whether patients are likely to face post-operative complications, in part due to biases based on individual experience. The purpose of this study was to develop and evaluate a predictive risk model and decision support system that could accurately predict the likelihood of 30-day postoperative complications in complex spine surgery based on routinely measured preoperative variables...
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28667363/which-patient-reported-factors-predict-referral-to-spinal-surgery-a-cohort-study-among-4987-chronic-low-back-pain-patients
#12
Johanna M van Dongen, Miranda L van Hooff, Maarten Spruit, Marinus de Kleuver, Raymond W J G Ostelo
PURPOSE: It is unknown which chronic low back pain (CLBP) patients are typically referred to spinal surgery. The present study, therefore, aimed to explore which patient-reported factors are predictive of spinal surgery referral among CLBP patients. METHODS: CLBP patients were consecutively recruited from a Dutch orthopedic hospital specialized in spine care (n = 4987). The outcome of this study was referral to spinal surgery (yes/no), and was assessed using hospital records...
June 30, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28667317/an-autoregressive-logistic-model-to-predict-the-reciprocal-effects-of-oviductal-fluid-components-on-in-vitro-spermophagy-by-neutrophils-in-cattle
#13
Rasoul Kowsar, Behrooz Keshtegar, Mohamed A Marey, Akio Miyamoto
After intercourse/insemination, large numbers of sperm are deposited in the female reproductive tract (FRT), triggering a massive recruitment of neutrophils (PMNs) into the FRT, possibly to eliminate excessive sperm via phagocytosis. Some bovine oviductal fluid components (BOFCs) have been shown to regulate in vitro sperm phagocytosis (spermophagy) by PMNs. The modeling approach-based logistic regression (LR) and autoregressive logistic regression (ALR) can be used to predict the behavior of complex biological systems...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666861/derivation-and-validation-of-the-prediabetes-self-assessment-screening-score-after-acute-pancreatitis-perseus
#14
Danielle H E Soo, Sayali A Pendharkar, Chirag J Jivanji, Nicola A Gillies, John A Windsor, Maxim S Petrov
BACKGROUND AND AIM: Approximately 40% of patients develop abnormal glucose metabolism after a single episode of acute pancreatitis. This study aimed to develop and validate a prediabetes self-assessment screening score for patients after acute pancreatitis. METHODS: Data from non-overlapping training (n=82) and validation (n=80) cohorts were analysed. Univariate logistic and linear regression identified variables associated with prediabetes after acute pancreatitis...
June 7, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28662632/timing-of-delivery-in-a-high-risk-obstetric-population-a-clinical-prediction-model
#15
Dane A De Silva, Sarka Lisonkova, Peter von Dadelszen, Anne R Synnes, Laura A Magee
BACKGROUND: The efficacy of antenatal corticosteroid treatment for women with threatened preterm birth depends on timely administration within 7 days before delivery. We modelled the probability of delivery within 7 days of admission to hospital among women presenting with threatened preterm birth, using routinely collected clinical characteristics. METHODS: Data from the Canadian Perinatal Network (CPN) were used, 2005-11, including women admitted to hospital with preterm labour, preterm pre-labour rupture of membranes, short cervix without contractions, or dilated cervix or prolapsed membranes without contractions at preterm gestation...
June 29, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28662377/a-multifactor-model-for-predicting-mortality-in-critically-ill-patients-a-multicenter-prospective-cohort-study
#16
Zhongwang Li, Baoli Cheng, Jingya Wang, Guohao Xie, Xiaobo Yu, Man Huang, Zhijun Xu, Zhongqiu Lu, Huaqin Sun, Jian Zhang, Zhiyi Wang, Haiya Wu, Xu Liu, Lihua Chu, Jialian Zhao, Xiangming Fang
PURPOSE: The objective of this study was to develop a model using a combination of routine clinical variables to predict mortality in critically ill patients. METHODS: A cohort of 500 patients recruited from eight university hospital intensive care units (ICUs) was used to develop a model via logistic regression analyses. Discrimination and calibration analyses were performed to assess the model. RESULTS: The model included the lactate level (odds ratio [OR]=1...
June 16, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28652813/charlson-comorbidity-index-derived-from-chart-review-or-administrative-data-agreement-and-prediction-of-mortality-in-intensive-care-patients
#17
Knut Stavem, Henrik Hoel, Stein Arve Skjaker, Rolf Haagensen
PURPOSE: This study compared the Charlson comorbidity index (CCI) information derived from chart review and administrative systems to assess the completeness and agreement between scores, evaluate the capacity to predict 30-day and 1-year mortality in intensive care unit (ICU) patients, and compare the predictive capacity with that of the Simplified Acute Physiology Score (SAPS) II model. PATIENTS AND METHODS: Using data from 959 patients admitted to a general ICU in a Norwegian university hospital from 2007 to 2009, we compared the CCI score derived from chart review and administrative systems...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28651935/derivation-and-validation-of-a-novel-risk-score-for-safe-discharge-after-acute-lower-gastrointestinal-bleeding-a-modelling-study
#18
Kathryn Oakland, Vipul Jairath, Raman Uberoi, Richard Guy, Lakshmana Ayaru, Neil Mortensen, Mike F Murphy, Gary S Collins
BACKGROUND: Acute lower gastrointestinal bleeding is a common reason for emergency hospital admission, and identification of patients at low risk of harm, who are therefore suitable for outpatient investigation, is a clinical and research priority. We aimed to develop and externally validate a simple risk score to identify patients with lower gastrointestinal bleeding who could safely avoid hospital admission. METHODS: We undertook model development with data from the National Comparative Audit of Lower Gastrointestinal Bleeding from 143 hospitals in the UK in 2015...
June 23, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28650186/incremental-prediction-of-intimate-partner-violence-an-examination-of-three-risk-measures
#19
Mark E Olver, Sandy Jung
Improvements in the risk prediction of domestic violence against intimate partners have the potential to inform policing practices in the prevention of further victimization. The present study examined the incremental predictive validity of 3 measures of risk for intimate partner violence (IPV)-Spousal Assault Risk Assessment (SARA), Ontario Domestic Assault Risk Assessment (ODARA), and the Family Violence Investigative Report (FVIR)-for IPV, general violence, and general recidivism outcomes. The sample featured 289 men and women who were reported to police for IPV and followed up approximately 3 years post release...
June 26, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/28645803/grace-risk-score-sex-based-validity-of-in-hospital-mortality-prediction-in-canadian-patients-with-acute-coronary-syndrome
#20
Inna Y Gong, Shaun G Goodman, David Brieger, Chris P Gale, Derek P Chew, Robert C Welsh, Thao Huynh, J Paul DeYoung, Carolyn Baer, Gabor T Gyenes, Jacob A Udell, Keith A A Fox, Andrew T Yan
BACKGROUND: Although there are sex differences in management and outcome of acute coronary syndromes (ACS), sex is not a component of Global Registry of Acute Coronary Events (GRACE) risk score (RS) for in-hospital mortality prediction. We sought to determine the prognostic utility of GRACE RS in men and women, and whether its predictive accuracy would be augmented through sex-based modification of its components. METHODS: Canadian men and women enrolled in GRACE and Canadian Registry of Acute Coronary Events were stratified as ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation ACS (NSTE-ACS)...
June 15, 2017: International Journal of Cardiology
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