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https://www.readbyqxmd.com/read/29353400/a-stard-compliant-prediction-model-for-diagnosing-thrombotic-microangiopathies
#1
Pietro Manuel Ferraro, Gianmarco Lombardi, Alessandro Naticchia, Antonio Sturniolo, Cecilia Zuppi, Valerio De Stefano, Patrizia Bonelli, Ruggero Buonocore, Gianfranco Cervellin, Giuseppe Lippi, Giovanni Gambaro
Aim of the study was the definition of a predictive model for the initial diagnosis of thrombotic microangiopathies (TMA). We retrospectively collected data on all adult patients admitted to the Gemelli Hospital from 2010 to 2014. ICD-9 codes from primary diagnoses were used for TMA diagnosis. Demographic and laboratory characteristics on admission of patients with TMA were then compared with a random sample of 500 patients with other diagnoses. The prediction model was externally validated in a cohort from another hospital...
January 20, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29353289/the-new-agreement-of-the-international-riga-consensus-conference-on-nasal-airway-function-tests
#2
K Vogt, G Bachmann-Harildstad, A Lintermann, A Nechyporenko, F Peters, K D Wernecke
The report reflects an agreement based on the consensus conference of the International Standardization Committee on the Objective Assessment of the Nasal Airway in Riga, 2nd Nov. 2016. The aim of the conference was to address the existing nasal airway function tests and to take into account physical, mathematical and technical correctness as a base of international standardization as well as the requirements of the Council Directive 93/42/EEC of 14 June 1993 concerning medical devices. Rhinomanometry, acoustic rhinometry, peak nasal inspiratory flow, Odiosoft-Rhino, optical rhinometry, 24-h measurements, computational fluid dynamics, nasometry and the mirrow test were evaluated for important diagnostic criteria, which are the precision of the equipment including calibration and the software applied; validity with sensitivity, specificity, positive and negative predictive values, reliability with intra-individual and inter-individual reproducibility and responsiveness in clinical studies...
January 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29353216/an-efficient-swarm-intelligence-approach-to-feature-selection-based-on-invasive-weed-optimization-application-to-multivariate-calibration-and-classification-using-spectroscopic-data
#3
Saheleh Sheykhizadeh, Abdolhossein Naseri
Variable selection plays a key role in classification and multivariate calibration. Variable selection methods are aimed at choosing a set of variables, from a large pool of available predictors, relevant to the analyte concentrations estimation, or to achieve better classification results. Many variable selection techniques have now been introduced among which, those which are based on the methodologies of swarm intelligence optimization have been more respected during a few last decades since they are mainly inspired by nature...
January 12, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29353126/evaluation-of-gamma-contribution-in-a-neutron-calibration-field-of-am-be241-source
#4
Thiem Ngoc Le, Hoai-Nam Tran, Thang Duc Duong, Quynh Ngoc Nguyen, Tuan Quang Ho, Giap Van Trinh, Khai Tuan Nguyen
The paper presents the evaluation of gamma contribution in a neutron calibration field of a 241Am-Be source. The characterization of gamma flux spectra and gamma ambient dose equivalent rates has been performed using a portable NaI(Tl) gamma spectrometer. For obtaining the gamma ambient dose equivalent rates from the measured spectra, two approaches were applied based on the applications of the G(E) function and the ICRP 74 conversion factors, respectively. Comparison of the gamma ambient dose equivalent rates obtained from the two approaches shows an agreement within 5%...
January 6, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29353024/outcomes-and-mortality-prediction-model-of-critically-ill-adults-with-acute-respiratory-failure-and-interstitial-lung-disease
#5
Whitney Gannon, David J Lederer, Mauer Biscotti, Azka Javaid, Nina Patel, Daniel Brodie, Matthew Bacchetta, Matthew Baldwin
BACKGROUND: We aimed to examine short- and long-term mortality in a mixed population of interstitial lung disease (ILD) patients with acute respiratory failure, and to identify those at lower versus higher risk of in-hospital death. METHODS: We conducted a single-center retrospective cohort study of 126 consecutive adults with ILD admitted to an intensive care unit (ICU) for respiratory failure at a tertiary care hospital between 2010 and 2014 who did not undergo lung transplantation during their hospitalization...
January 15, 2018: Chest
https://www.readbyqxmd.com/read/29352739/determination-of-protein-oligomeric-structure-from-small-angle-x-ray-scattering
#6
REVIEW
David A Korasick, John J Tanner
Small-angle X-ray scattering (SAXS) is useful for determining the oligomeric states and quaternary structures of proteins in solution. The average molecular mass in solution can be calculated directly from a single SAXS curve collected on an arbitrary scale from a sample of unknown protein concentration, without the need for beamline calibration or protein standards. The quaternary structure in solution can be deduced by comparing the experimental SAXS curve to theoretical curves calculated from proposed models of the oligomer...
January 20, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29352643/assessment-of-a-source-position-checking-tool-for-the-quality-assurance-of-transfer-tubes-used-in-hdr-192ir-brachytherapy-treatments
#7
O A Awunor
PURPOSE: The determination of source positions before treatment is an essential part of the quality assurance (QA) associated with high dose rate brachytherapy treatments. The purpose of this study was to design and commission a tool to allow the quantification of source positions across multiple transfer tube types. METHODS AND MATERIALS: A bespoke flexi-adapter jig, three transfer tube adapters, and a film piercing pointer were designed and built for source position QA across three transfer tube types-the standard, 6 French, and gynae transfer tubes...
January 15, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29352440/the-limitations-of-standard-clinicopathologic-features-to-accurately-risk-stratify-prognosis-after-resection-of-intrahepatic-cholangiocarcinoma
#8
Fabio Bagante, Katiuscha Merath, Malcolm H Squires, Matthew Weiss, Sorin Alexandrescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Olivier Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
BACKGROUND: The ability to provide accurate prognostic data after hepatectomy for intrahepatic cholangiocarcinoma (ICC) remains poor. We sought to develop and validate a nomogram to predict survival, as well as investigate the clinical implications of underestimating patients' risk of recurrence. METHODS: Patients undergoing curative-intent resection of ICC between 1990 and 2015 at 14 major hepatobiliary centers were included. Variables significant on multivariable analysis were used to construct a nomogram to predict disease-free survival (DFS)...
January 19, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29352326/noninvasive-pulse-contour-analysis-for-determination-of-cardiac-output-in-patients-with-chronic-heart-failure
#9
Sebastian Roth, Henrik Fox, Uwe Fuchs, Uwe Schulz, Angelika Costard-Jäckle, Jan F Gummert, Dieter Horstkotte, Olaf Oldenburg, Thomas Bitter
BACKGROUND: Determination of cardiac output (CO) is essential in diagnosis and management of heart failure (HF). The gold standard to obtain CO is invasive assessment via thermodilution (TD). Noninvasive pulse contour analysis (NPCA) is supposed as a new method of CO determination. However, a validation of this method in HF is pending and performed in the present study. METHODS: Patients with chronic-stable HF and reduced left ventricular ejection fraction (LVEF ≤ 45%; HF-REF) underwent right heart catheterization including TD...
January 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29352162/a-prolonged-run-in-period-of-standard-subcutaneous-microdialysis-ameliorates-quality-of-interstitial-glucose-signal-in-patients-after-major-cardiac-surgery
#10
Othmar Moser, Julia Münzker, Stefan Korsatko, Christoph Pachler, Karlheinz Smolle, Wolfgang Toller, Thomas Augustin, Johannes Plank, Thomas R Pieber, Julia K Mader, Martin Ellmerer
We evaluated a standard subcutaneous microdialysis technique for glucose monitoring in two critically ill patient populations and tested whether a prolonged run-in period improves the quality of the interstitial glucose signal. 20 surgical patients after major cardiac surgery (APACHE II score: 10.1 ± 3.2) and 10 medical patients with severe sepsis (APACHE II score: 31.1 ± 4.3) were included in this investigation. A microdialysis catheter was inserted in the subcutaneous adipose tissue of the abdominal region...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351762/inclusion-of-edaphic-predictors-for-enhancement-of-models-to-determine-distribution-of-soil-transmitted-helminths-the-case-of-zimbabwe
#11
Nicholas Midzi, Blessing Kavhu, Portia Manangazira, Isaac Phiri, Susan L Mutambu, Cremants Tshuma, Moses J Chimbari, Shungu Munyati, Stanely M Midzi, Lincon Charimari, Anatoria Ncube, Masceline J Mutsaka-Makuvaza, White Soko, Emmanuel Madzima, Gibson Hlerema, Joel Mbedzi, Gibson Mhlanga, Mhosisi Masocha
BACKGROUND: Reliable mapping of soil-transmitted helminth (STH) parasites requires rigorous statistical and machine learning algorithms capable of integrating the combined influence of several determinants to predict distributions. This study tested whether combining edaphic predictors with relevant environmental predictors improves model performance when predicting the distribution of STH, Ascaris lumbricoides and hookworms at a national scale in Zimbabwe. METHODS: Geo-referenced parasitological data obtained from a 2010/2011 national survey indicating a confirmed presence or absence of STH among school children aged 10-15 years was used to calibrate ten species distribution models (SDMs)...
January 19, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29351661/estimation-of-measurement-uncertainty-in-quantitation-of-benzoylecgonine-bze-and-11-nor-%C3%AE-9-thc-9-carboxylic-acid-thca
#12
Darryl P Arfsten, Erick Roman Perez, Neal C Goebel
Calculating measurement uncertainty is a helpful exercise for identifying components or steps in a forensic analytical procedure that contribute to measurement variance. In this study, we used a bottom up approach to identify components in our procedures that contribute to measurement variance in our Department of Defense (DoD) Drug Demand Reduction Program (DDRP) Gas Chromatography Mass Spectroscopy (GCMS) analytical procedures for benzoylecgonine (BZE) and the THC metabolite, 11-nor-Δ9-THC-9-carboxylic acid (THCA) at 125% the DDRP concentration threshold (cutoff)...
January 17, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29351653/calibration-of-gafchromic-ebt3-film-for-dosimetry-of-scanning-proton-pencil-beam-pbs
#13
D Krzempek, G Mianowska, N Bassler, L Stolarczyk, R Kopec, B Sas-Korczynska, P Olko
Gafchromic EBT3 films are applied in proton radiotherapy for 2D dose mapping because they demonstrate spatial resolution well below 1 mm. However, the film response must be corrected in order to reach the accuracy of dose measurements required for the clinical use. The in-house developed AnalyseGafchromic software allows to analyze and correct the measured response using triple channel dose calibration, statistical scan-to-scan fluctuations as well as experimentally determined dose and LET dependence. Finally, the optimized protocol for evaluation of response of Gafchromic EBT3 films was applied to determine 30 × 40 cm2 dose profiles of the scanning therapy unit at the Cyclotron Centre Bronowice, CCB in Krakow, Poland...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29351467/from-ionic-to-cellular-variability-in-human-atrial-myocytes-an-integrative-computational-and-experimental-study
#14
Anna Muszkiewicz, Xing Liu, Alfonso Bueno-Orovio, Brodie A J Lawson, Kevin Burrage, Barbara Casadei, Blanca Rodriguez
Variability refers to differences in physiological function between individuals, which may translate into different disease susceptibility and treatment efficacy. Experiments in human cardiomyocytes face wide variability and restricted tissue access; under these conditions computational models are a useful complementary tool. We conducted a computational and experimental investigation in cardiomyocytes isolated from samples of the right atrial appendage of patients undergoing cardiac surgery to evaluate the impact of variability in action potentials (APs) and sub-cellular ionic densities on calcium transient dynamics...
December 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351329/radiocarbon-dating-uncertainty-and-the-reliability-of-the-pewma-method-of-time-series-analysis-for-research-on-long-term-human-environment-interaction
#15
W Christopher Carleton, David Campbell, Mark Collard
Statistical time-series analysis has the potential to improve our understanding of human-environment interaction in deep time. However, radiocarbon dating-the most common chronometric technique in archaeological and palaeoenvironmental research-creates challenges for established statistical methods. The methods assume that observations in a time-series are precisely dated, but this assumption is often violated when calibrated radiocarbon dates are used because they usually have highly irregular uncertainties...
2018: PloS One
https://www.readbyqxmd.com/read/29351206/antibody-biomimetic-material-made-of-pyrrole-for-ca-15-3-and-its-application-as-sensing-material-in-ion-selective-electrodes-for-potentiometric-detection
#16
Alexandra R T Santos, Felismina T C Moreira, Luísa A Helguero, M Goreti F Sales
This work reports a very simple approach for creating a synthetic antibody against any protein of interest and its application in potentiometric transduction. The selected protein was Breast Cancer Antigen (CA 15-3), which is implicated in breast cancer disease and used to follow-up breast cancer patients during treatment. The new material with antibody-like properties was obtained by molecular-imprinting technology, prepared by electropolymerizing pyrrol (Py, 5.0 × 10-3 mol/L) around Breast Cancer Antigen (CA 15-3) (100 U/mL) on a fluorine doped tin oxide (FTO) conductive glass support...
January 19, 2018: Biosensors
https://www.readbyqxmd.com/read/29350466/simultaneous-extraction-and-determination-of-trace-amounts-of-diclofenac-from-whole-blood-using-supported-liquid-membrane-microextraction-and-fast-fourier-transform-voltammetry
#17
Zahra Mofidi, Parviz Norouzi, Masumeh Sajadian, Mohammad Reza Ganjali
A novel, simple and inexpensive analytical technique based on flat sheet supported liquid membrane microextraction coupled with fast Fourier transform stripping cyclic voltammetry on a reduced graphene oxide carbon paste electrode was used for the extraction and online determination of diclofenac in whole blood. First, diclofenac was extracted from blood samples using a polytetrafluoroethylene membrane impregnated with 1-octanol and then into an acceptor solution, subsequently it was oxidized on a carbon paste electrode modified with reduced graphene oxide nano-sheets...
January 19, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29350408/calibration-and-non-orthogonality-correction-of-three-axis-hall-sensors-for-the-monitoring-of-mri-workers-exposure-to-static-magnetic-fields
#18
Antoine Delmas, Lamia Belguerras, Nicolas Weber, Freddy Odille, Cédric Pasquier, Jacques Felblinger, Pierre-André Vuissoz
A Magnetic Resonance Imaging (MRI) scanner uses three different electromagnetic fields (EMF) to produce body images: a static permanent magnetic field (MF), several pulsed magnetic gradients, and a radiofrequency pulse. As a result, any occupation that includes an MRI exposes workers to a strong MF. The World Health Organization has now given the monitoring of occupational EMF exposure a high priority. One design for a low-cost, compact MF exposure monitor (« MR exposimeter ») uses a set of three orthogonally assembled Hall sensors...
January 19, 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29350190/development-and-validation-of-a-high-resolution-mapping-platform-to-aid-in-the-public-awareness-of-radiological-hazards
#19
Peter George Martin, Dean Connor, Oliver David Payton, Macarena Leal-Olloqui, Anya C Keatley, Thomas B Scott
The distribution, quantification and exposure-related effects of radiation in the environment, arising from both natural and anthropogenic sources, is of great (and growing) concern for global populations. Recent events at the Fukushima Daiichi Nuclear Plant (FDNPP) have further highlighted the importance of developing radiation mapping technologies that not only contribute to the continued assessment of contamination, but can also serve as an educational tool for members of the public regarding its behaviour and extent...
January 19, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29350088/the-use-of-synthetic-ligaments-in-the-design-of-an-enhanced-stability-total-knee-joint-replacement
#20
Michael D Stokes, Brendan C Greene, Luke W Pietrykowski, Taylor M Gambon, Caroline E Bales, John D DesJardins
Current total knee replacement designs work to address clinically desired knee stability and range of motion through a balance of retained anatomy and added implant geometry. However, simplified implant geometries such as bearing surfaces, posts, and cams are often used to replace complex ligamentous constraints that are sacrificed during most total knee replacement procedures. This article evaluates a novel total knee replacement design that incorporates synthetic ligaments to enhance the stability of the total knee replacement system...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
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