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https://www.readbyqxmd.com/read/28454077/comparison-of-ftir-atr-and-raman-spectroscopy-in-determination-of-vldl-triglycerides-in-blood-serum-with-pls-regression
#1
Adam Oleszko, Jadwiga Hartwich, Anna Wójtowicz, Marlena Gąsior-Głogowska, Hubert Huras, Małgorzata Komorowska
Hypertriglyceridemia, related with triglyceride (TG) in plasma above 1.7mmol/L is one of the cardiovascular risk factors. Very low density lipoproteins (VLDL) are the main TG carriers. Despite being time consuming, demanding well-qualified staff and expensive instrumentation, ultracentrifugation technique still remains the gold standard for the VLDL isolation. Therefore faster and simpler method of VLDL-TG determination is needed. Vibrational spectroscopy, including FT-IR and Raman, is widely used technique in lipid and protein research...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28454067/assessment-of-the-swat-model-to-simulate-a-watershed-with-limited-available-data-in-the-pampas-region-argentina
#2
Martín Romagnoli, Margarita Portapila, Alfredo Rigalli, Gisela Maydana, Martín Burgués, Carlos M García
Argentina has been among the world leaders in the production and export of agricultural products since the 1990s. The Carcarañá River Lower Basin (CRLB), a cropland of the Pampas region supplied by extensive rainfall, is located in an area with few streamgauging and other hydrologic/water-quality stations. Therefore, limited hydrologic data are available resulting in limited water-resources assessment. This work explores the application of Soil and Water Assessment Tool (SWAT) model to the CRLB in the Santa Fe province of the Pampas region...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454022/quantitative-analysis-of-adsorptive-interactions-of-ionic-and-neutral-pharmaceuticals-and-other-chemicals-with-the-surface-of-escherichia-coli-cells-in-aquatic-environment
#3
Chul-Woong Cho, Jeong-Soo Park, Yufeng Zhao, Yeoung-Sang Yun
Since Escherichia coli is ubiquitous in nature and has been applied to biological, chemical, and environmental processes, molecular-level understanding of adsorptive interactions between chemicals and the bacterial surface is of great importance. To characterise the adsorption properties of the surface of E. coli cells in aquatic environment, the binding affinities (log Kd) of calibration compounds were experimentally measured, and then based on the values and numerically well-defined molecular interaction forces, i...
April 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28453749/an-independently-validated-nomogram-for-individualized-estimation-of-survival-among-patients-with-newly-diagnosed-glioblastoma-nrg-oncology-rtog-0525-and-0825
#4
Haley Gittleman, Daniel Lim, Michael W Kattan, Arnab Chakravarti, Mark R Gilbert, Andrew B Lassman, Simon S Lo, Mitchell Machtay, Andrew E Sloan, Erik P Sulman, Devin Tian, Michael A Vogelbaum, Tony J C Wang, Marta Penas-Prado, Emad Youssef, Deborah T Blumenthal, Peixin Zhang, Minesh P Mehta, Jill S Barnholtz-Sloan
Background.: Glioblastoma (GBM) is the most common primary malignant brain tumor. Nomograms are often used for individualized estimation of prognosis. This study aimed to build and independently validate a nomogram to estimate individualized survival probabilities for patients with newly diagnosed GBM, using data from 2 independent NRG Oncology Radiation Therapy Oncology Group (RTOG) clinical trials. Methods.: This analysis included information on 799 (RTOG 0525) and 555 (RTOG 0825) eligible and randomized patients with newly diagnosed GBM and contained the following variables: age at diagnosis, race, gender, Karnofsky performance status (KPS), extent of resection, O6-methylguanine-DNA methyltransferase (MGMT) methylation status, and survival (in months)...
May 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28453544/predicting-herbivore-faecal-nitrogen-using-a-multispecies-near-infrared-reflectance-spectroscopy-calibration
#5
Miriam Villamuelas, Emmanuel Serrano, Johan Espunyes, Néstor Fernández, Jorge R López-Olvera, Mathieu Garel, João Santos, María Ángeles Parra-Aguado, Maurizio Ramanzin, Xavier Fernández-Aguilar, Andreu Colom-Cadena, Ignasi Marco, Santiago Lavín, Jordi Bartolomé, Elena Albanell
Optimal management of free-ranging herbivores requires the accurate assessment of an animal's nutritional status. For this purpose 'near-infrared reflectance spectroscopy' (NIRS) is very useful, especially when nutritional assessment is done through faecal indicators such as faecal nitrogen (FN). In order to perform an NIRS calibration, the default protocol recommends starting by generating an initial equation based on at least 50-75 samples from the given species. Although this protocol optimises prediction accuracy, it limits the use of NIRS with rare or endangered species where sample sizes are often small...
2017: PloS One
https://www.readbyqxmd.com/read/28453512/a-reproducible-semi-automatic-method-to-quantify-the-muscle-lipid-distribution-in-clinical-3d-ct-images-of-the-thigh
#6
Alexander Mühlberg, Oleg Museyko, Jean-Denis Laredo, Klaus Engelke
Many studies use threshold-based techniques to assess in vivo the muscle, bone and adipose tissue distribution of the legs using computed tomography (CT) imaging. More advanced techniques divide the legs into subcutaneous adipose tissue (SAT), anatomical muscle (muscle tissue and adipocytes within the muscle border) and intra- and perimuscular adipose tissue. In addition, a so-called muscle density directly derived from the CT-values is often measured. We introduce a new integrated approach to quantify the muscle-lipid system (MLS) using quantitative CT in patients with sarcopenia or osteoporosis...
2017: PloS One
https://www.readbyqxmd.com/read/28453501/measuring-alcohol-marketing-engagement-the-development-and-psychometric-properties-of-the-alcohol-marketing-engagement-scale
#7
Angela Robertson, David T Morse, Kristina Hood, Courtney Walker
Ample evidence exists in support of the influence of media, both traditional and electronic, on perceptions and engagement with alcohol marketing. We describe the development, calibration, and evidence for technical quality and utility for a new measure, the Alcohol Marketing Engagement Scale. Using two samples of college undergraduates (n1 = 199, n2 = 732), we collected field test responses to a total of 13 items. Initial support for scale validity is presented via correlations with attributes previously shown to be related to alcohol engagement...
2017: Journal of Applied Measurement
https://www.readbyqxmd.com/read/28453293/predicting-a-drug-s-membrane-permeability-a-computational-model-validated-with-in-vitro-permeability-assay-data
#8
Brian J Bennion, Nicholas A Be, Margaret Windy McNerney, Victoria Lao, Emma M Carlson, Carlos A Valdez, Michael A Malfatti, Heather A Enright, Tuan H Nguyen, Felice C Lightstone, Timothy S Carpenter
Membrane permeability is a key property to consider during the drug design process, and particularly vital when dealing with small molecules that have intracellular targets as their efficacy highly depends on their ability to cross the membrane. In this work, we describe the use of umbrella sampling Molecular Dynamics (MD) computational modeling to comprehensively assess the passive permeability profile of a range of compounds through a lipid bilayer. The model was initially calibrated through in vitro validation studies employing a Parallel Artificial Membrane Permeability Assay (PAMPA)...
April 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28453252/polymer-inclusion-membranes-with-condensed-phase-membrane-introduction-mass-spectrometry-cp-mims-improved-analytical-response-time-and-sensitivity
#9
Gregory W Vandergrift, Erik T Krogh, Chris G Gill
Condensed phase membrane introduction mass spectrometry (CP-MIMS) is an online, in situ analysis technique for low volatility analytes. Analytes diffuse through a hollow fibre membrane, where they are then dissolved by a liquid (condensed) acceptor phase flowing through the membrane lumen. Permeating analytes are entrained to an atmospheric pressure ionization source for subsequent measurement by a mass spectrometer. Larger analytes, with inherently lower diffusivities, suffer from lengthy response times and lower sensitivity, limiting the use of CP-MIMS for their online, real time measurement...
April 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28449457/nomogram-prediction-for-the-survival-of-the-patients-with-small-cell-lung-cancer
#10
Hui Pan, Xiaoshun Shi, Dakai Xiao, Jiaxi He, Yalei Zhang, Wenhua Liang, Zhi Zhao, Zhihua Guo, Xusen Zou, Jinxin Zhang, Jianxing He
BACKGROUND: Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. In this study, we aimed to build a nomogram to predict the survival of individual with SCLC by incorporating significant clinical parameters. METHODS: The patients with SCLC were enrolled from the First Affiliated Hospital of Guangzhou Medical University (GMUFAH) between 2009 and 2013. We identified and incorporated the independent prognostic factors to build a nomogram to predict the survival of SCLC patients...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449378/analysis-of-toldimfos-in-porcine-muscle-and-bovine-milk-using-liquid-chromatography-triple-quadrupole-mass-spectrometry
#11
Dan Zhang, Jin-A Park, A M Abd El-Aty, Seong-Kwan Kim, Sang-Hyun Cho, Weijia Zheng, Jeong-Min Choi, Jae-Han Shim, Byung-Joon Chang, Jin-Suk Kim, Ho-Chul Shin
An analytical method was developed for the detection of toldimfos sodium residues in porcine muscle and bovine milk using liquid chromatography-triple quadrupole tandem mass spectrometry (LC-MS/MS) analysis. The drug was extracted from muscle and milk using 10 mM ammonium formate in acetonitrile and then purified using n-hexane. The drug was well separated on a Luna C18 column using a mixture of 10 mM ammonium formate in ultrapure water (A) and acetonitrile (B) as the mobile phase. Good linearity was achieved over the tested concentration range (0...
April 27, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28449265/a-pilot-study-of-nocturnal-temporalis-muscle-activity-in-tmd-diagnostic-groups-of-women
#12
Feng Wei, Mark H Van Horn, Matthew C Coombs, Xin She, Theresa S Gonzales, Yoly M Gonzalez, JoAnna M Scott, Laura R Iwasaki, Jeffery C Nickel, Hai Yao
BACKGROUND: Temporomandibular disorder (TMD) incidences are believed to be related to parafunctional behaviors like teeth clenching. OBJECTIVES: This pilot study aimed to (i) develop an automated clench-detection algorithm, and (ii) apply the algorithm to test for differences in nocturnal clenching in women with and without TMD. METHODS: Subjects gave informed consent to participate. Adult women were categorized using Diagnostic Criteria for TMD according to presence/absence (+/-) of both TM joint disc placement (DD) and chronic pain (P) into two groups (+DD+P, -DD-P) with 12 subjects each...
April 27, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28449182/validation-of-a-nomogram-for-selecting-patients-for-chemotherapy-after-d2-gastrectomy-for-cancer
#13
Z-X Wang, G-X Li, Z-W Zhou, Z-P Huang, F Wang, R-H Xu
BACKGROUND: According to some guidelines for the management of gastric cancer, adjuvant chemotherapy is recommended for patients with pT3-4 or node-positive disease. The aim of this study was to define low- and high-risk groups in terms of survival, and to predict the benefit of adjuvant fluoropyrimidine plus oxaliplatin (F-OX) chemotherapy. METHODS: Patients with pT3-4 or node-positive gastric cancer after gastrectomy with D2 lymphadenectomy between 2000 and 2013 were included...
April 27, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28449104/liquid-chromatographic-chemometric-techniques-for-the-simultaneous-hplc-determination-of-lansoprazole-amoxicillin-and-clarithromycin-in-commercial-preparation
#14
A Hakan Aktas, Ayse Mine Saridag
Two multivariate calibration-prediction techniques, principal component regression (PCR) and partial least-squares regression (PLSR) were applied to the chromatographic multicomponent analysis of the drug containing lansoprazole (LAN), clarithromycin (CLA) and amoxicillin (AMO). Optimum chromatographic separation of LAN, CLA and AMO with atorvastatin as the internal standard (IS) was obtained by using Xterra® RP18 column 5 μm 4.6 × 250 mm2, and 25 mM ammonium chloride buffer prepared ammonium chloride, acetonitrile and bidistilled water (45:45:10 v/v) as the mobile phase at flow rate 1...
April 26, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28448927/time-varying-sensitivity-analysis-of-hydrologic-and-sediment-parameters-at-multiple-timescales-implications-for-conservation-practices
#15
Hui Xie, Zhenyao Shen, Lei Chen, Jiali Qiu, Jianwei Dong
Environmental models can be used to better understand the hydrologic and sediment behavior in a watershed system. However, different processes may dominate at different time periods and timescales, which highly complicate the model interpretation. The related parameter uncertainty may be significant and needs to be addressed to avoid bias in the watershed management. In this study, we used the time-varying and multi-timescale (TVMT) method to characterize the temporal dynamics of parameter sensitivity at different timescales in hydrologic and sediment modeling...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448747/a-hierarchical-bayesian-design-for-randomized-phase-ii-clinical-trials-with-multiple-groups
#16
Jun Yin, Rui Qin, Daniel J Sargent, Charles Erlichman, Qian Shi
Enhanced knowledge of the biological and genetic basis of cancer is re-defining target population for new treatments. In oncology, potential targets for a new therapeutic agent often include various solid and hematologic malignancies that share common signaling pathways. New agents are often tested in multiple tumor types across which information can be borrowed. We propose a hierarchical Bayesian design (HBD) to simultaneously test a novel agent in multiple groups for randomized phase II clinical trials with binary endpoints...
April 27, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28448607/complementing-the-topsoil-information-of-the-land-use-land-cover-area-frame-survey-lucas-with-modelled-n2o-emissions
#17
Emanuele Lugato, Lily Paniagua, Arwyn Jones, Wim de Vries, Adrian Leip
Two objectives of the Common Agricultural Policy post-2013 (CAP, 2014-2020) in the European Union (EU) are the sustainable management of natural resources and climate smart agriculture. To understand the CAP impact on these priorities, the Land Use/Cover statistical Area frame Survey (LUCAS) employs direct field observations and soil sub-sampling across the EU. While a huge amount of information can be retrieved from LUCAS points for monitoring the environmental status of agroecosystems and assessing soil carbon sequestration, a fundamental aspect relating to climate change action is missing, namely nitrous oxide (N2O) soil emissions...
2017: PloS One
https://www.readbyqxmd.com/read/28448582/comparison-of-multiple-obesity-indices-for-cardiovascular-disease-risk-classification-in-south-asian-adults-the-carrs-study
#18
Shivani A Patel, Mohan Deepa, Roopa Shivashankar, Mohammed K Ali, Deksha Kapoor, Ruby Gupta, Dorothy Lall, Nikhil Tandon, Viswanathan Mohan, M Masood Kadir, Zafar Fatmi, Dorairaj Prabhakaran, K M Venkat Narayan
BACKGROUND: We comparatively assessed the performance of six simple obesity indices to identify adults with cardiovascular disease (CVD) risk factors in a diverse and contemporary South Asian population. METHODS: 8,892 participants aged 20-60 years in 2010-2011 were analyzed. Six obesity indices were examined: body mass index (BMI), waist circumference (WC), waist-height ratio (WHtR), waist-hip ratio (WHR), log of the sum of triceps and subscapular skin fold thickness (LTS), and percent body fat derived from bioelectric impedance analysis (BIA)...
2017: PloS One
https://www.readbyqxmd.com/read/28448522/nestin-expression-is-upregulated-in-the-fibrotic-rat-heart-and-is-localized-in-collagen-expressing-mesenchymal-cells-and-interstitial-cd31-cells
#19
Vanessa Hertig, Kim Tardif, Marc Andre Meus, Natacha Duquette, Louis Villeneuve, Fanny Toussaint, Jonathan Ledoux, Angelino Calderone
Renal and lung fibrosis was characterized by the accumulation of collagen-immunoreactive mesenchymal cells expressing the intermediate filament protein nestin. The present study tested the hypothesis that nestin expression was increased in the hypertrophied/fibrotic left ventricle of suprarenal abdominal aorta constricted adult male Sprague-Dawley rats and induced in ventricular fibroblasts by pro-fibrotic peptide growth factors. Nestin protein levels were upregulated in the pressure-overloaded left ventricle and expression positively correlated with the rise of mean arterial pressure...
2017: PloS One
https://www.readbyqxmd.com/read/28448271/separate-patient-serum-sodium-medians-from-males-and-females-provide-independent-information-on-analytical-bias
#20
Steen Ingemann Hansen, Per Hyltoft Petersen, Flemming Lund, Callum G Fraser, György Sölétormos
BACKGROUND: During monitoring of monthly medians of results from patients undertaken to assess analytical stability in routine laboratory performance, the medians for serum sodium for male and female patients were found to be significantly related. METHODS: Daily, weekly and monthly patient medians of serum sodium for both male and female patients were calculated from results obtained on samples from the population >18 years on three analysers in the hospital laboratory...
April 27, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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