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https://www.readbyqxmd.com/read/28930093/a-reusable-osl-film-for-2d-radiotherapy-dosimetry
#1
Wouter Crijns, Dirk Adelin Vandenbroucke, Paul Leblans, Tom Depuydt
Purpose Optical stimulated luminescence (OSL) combines reusability, sub-mm resolution, and a linear dose response in a single radiation detection technology. Such a combination is currently lacking in radiotherapy dosimetry. But OSL-films have a strong energy dependent response to keV photons due to a relative high effective atomic number (Zeff). The current work studied the applicability of a 2D OSL-film with a reduced Zeff as (IMRT/VMAT) dosimeter. Methods and Materials Based on their commercial OSL-film experience, Agfa Healthcare N...
September 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28930046/canadian-benchmarks-for-acute-injury-care
#2
Lynne Moore, David Evans, Natalie L Yanchar, Jaimini Thakore, Henry Thomas Stelfox, Sayed Morad Hameed, Richard Simons, John Kortbeek, Julien Clément, François Lauzier, Alexis F Turgeon
BACKGROUND: Acute care injury outcomes vary substantially across Canadian provinces and trauma centres. Our aim was to develop Canadian benchmarks to monitor mortality and hospital length of stay (LOS) for injury admissions. METHODS: Benchmarks were derived using data from the Canadian National Trauma Registry on patients with major trauma admitted to any level I or II trauma centre in Canada and from the following patient subgroups: isolated traumatic brain injury (TBI), isolated thoracoabdominal injury, multisystem blunt injury, age 65 years or older...
October 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28929781/express-a-review-of-calibration-transfer-practices-and-instrument-differences-in-spectroscopy
#3
Jerry Workman
No abstract text is available yet for this article.
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28929734/label-free-and-high-throughput-detection-of-biomolecular-interactions-using-a-flatbed-scanner-biosensor
#4
Ugur Aygun, Oguzhan Avci, Elif Seymour, Hakan Urey, M Selim Ünlu, Ayca Yalcin Ozkumur
Fluorescence based microarray detection systems provide sensitive measurements, however variation of probe immobilization and poor repeatability negatively affect the final readout, and thus quantification capability of these systems. Here, we demonstrate a label-free and high-throughput optical biosensor that can be utilized for calibration of fluorescence microarrays. The sensor employs a commercial flatbed scanner, and we demonstrate transformation of this low cost (100 USD) system into an Interferometric Reflectance Imaging Sensor through hardware and software modifications...
September 20, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28929716/-developing-an-algorithm-based-on-health-and-social-sources-to-stratify-general-population-in-different-levels-of-health-socio-sanitary-frailty-and-disability
#5
Laura Andreoni, Antonio Giampiero Russo
OBJECTIVES: to describe an innovative algorithm to classify the general population, in homogeneous groups of severity and complexity of disease and real needs, by using three dimensions: health, frailty, and disability. DESIGN: retrospective cohort study. SETTING AND PARTICIPANTS: the study includes the population covered by the Agency for health protection of Metropolitan Area of Milan (3,4 million of habitants). We identified two cohorts of residents: the first at 01...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929504/simultaneous-determination-of-serum-propafenone-and-its-metabolites-using-high-performance-liquid-chromatography
#6
Yuki Shirayama, Kosuke Doki, Yukio Sekiguchi, Kazutaka Aonuma, Yukinao Kohda, Masato Homma
Propafenone, a class Ic antiarrhythmic agent, is metabolized to 5-hydroxypropafeone (5-OHP) and N-depropylpropafenone (NDPP). Simultaneous determination of serum propafenone and its metabolites was performed using high-performance liquid chromatography (HPLC) equipped with a conventional octadecylsilyl silica column and ultraviolet detector. The wavelength was set at 250 nm. Propafenone and its metabolites in the serum were extracted using diethyl ether. The mobile phase solution, comprising 1-pentanesulfonic acid sodium salt (0...
September 19, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28929199/sophorolipid-production-by-yeasts-a-critical-review-of-the-literature-and-suggestions-for-future-research
#7
REVIEW
Silke Claus, Inge N A Van Bogaert
Sophorolipids are well-known biosurfactants produced by yeasts, having potential applications ranging from nanomaterials, medicine, and cosmetics to large-volume applications such as cleaning and soil remediation. Because of their environmentally friendly nature, they attained much interest during the past decades as a sustainable and ecological alternative to petroleum-derived surfactants. Stronger yet, research activities and scientific publications on the topic are ever increasing. However, often these studies lack proper producer strain identification and detailed structural product characterization...
September 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28928857/updated-nomogram-incorporating-percentage-of-positive-cores-to-predict-probability-of-lymph-node-invasion-in-prostate-cancer-patients-undergoing-sentinel-lymph-node-dissection
#8
Alexander Winter, Thomas Kneib, Clara Wasylow, Lena Reinhardt, Rolf-Peter Henke, Svenja Engels, Holger Gerullis, Friedhelm Wawroschek
Objectives: To update the first sentinel nomogram predicting the presence of lymph node invasion (LNI) in prostate cancer patients undergoing sentinel lymph node dissection (sPLND), taking into account the percentage of positive cores. Patients and Methods: Analysis included 1,870 prostate cancer patients who underwent radioisotope-guided sPLND and retropubic radical prostatectomy. Prostate-specific antigen (PSA), clinical T category, primary and secondary biopsy Gleason grade, and percentage of positive cores were included in univariate and multivariate logistic regression models predicting LNI, and constituted the basis for the regression coefficient-based nomogram...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28927995/measuring-system-for-an-attitude-angle-of-a-denture-using-an-inertial-measurement-unit
#9
Toshiaki Sekita, Syuhei Takeuchi, Syunsuke Minakuchi
PURPOSE: The aim of this study was to assemble and verify a measuring system for 3-D movements (attitude angle) of the denture during function. METHODS: For the calibration test, the sensor was fixed at the center of the rotary table. Operation and stopping of the rotary table were repeated 8 times, and the direction of rotation was reversed in the middle. The amount of rotation was 1.2 and 2.4°. As a pilot clinical trial, the attitude angles of three upper complete dentures during tapping were measured by this system...
September 15, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28927836/disintegration-rate-and-gamma-ray-emission-probability-per-decay-measurement-of-cu-64
#10
I M Yamazaki, M F Koskinas, D S Moreira, M N Takeda, M S Dias
The procedure followed by the Nuclear Metrology Laboratory (LMN) at the IPEN for the standardization of activity of (64)Cu is described. The measurement was carried out in a 4π (PC) β-γ coincidence system. The activity per unit mass of the solution was determined by the extrapolation technique. The events were registered using a Time to Amplitude Converter (TAC) associated with a Multi-channel Analyzer. The gamma-ray emission probability per decay of the 1345.7keV transition of (64)Cu determined with a calibrated REGe gamma-ray spectrometer was (0...
September 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28927782/development-and-internal-validation-of-prediction-models-for-biochemical-failure-and-composite-failure-after-focal-salvage-high-intensity-focused-ultrasound-for-local-radiorecurrent-prostate-cancer-presentation-of-risk-scores-for-individual-patient-prognoses
#11
Max Peters, Abi Kanthabalan, Taimur T Shah, Neil McCartan, Caroline M Moore, Manit Arya, Jochem R van der Voort van Zyp, Marinus A Moerland, Richard G Hindley, Mark Emberton, Hashim U Ahmed
PURPOSE: Patient selection for focal salvage remains difficult. Therefore, we developed and internally validated prediction models for biochemical failure (BF) and a composite endpoint (CE) following focal salvage high intensity focused ultrasound (HIFU) for radiorecurrent prostate cancer. MATERIALS AND METHODS: A prospective HIFU registry identified 150 cases (November 2006-August 2015). Recurrence was assessed with multiparametric magnetic resonance imaging (MRI) combined with template prostate mapping biopsies, targeted biopsies, or systematic transrectal ultrasound-guided biopsies...
September 15, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28927642/iterative-approach-for-3d-reconstruction-of-the-femur-from-un-calibrated-2d-radiographic-images
#12
Kibeom Youn, Moon Soek Park, Jehee Lee
Three-dimensional reconstruction of the femur is important for surgical planning in patients with cerebral palsy. This study aimed to reconstruct the three-dimensional femur shape from un-calibrated bi-planar radiographic images using self-calibration to allow for low-dose preoperative planning. The existing self-calibration techniques require anatomical landmarks that are clearly visible on bi-planar images, which are not available on the femur. In our newly developed method, the self-calibration is performed so that the contour of the statistical shape matches the image contour while the statistical shape is concomitantly optimized...
September 15, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28927486/hplc-determination-of-total-tryptophan-in-infant-formula-and-adult-pediatric-nutritional-formula-following-enzymatic-hydrolysis-single-laboratory-validation-first-action-2017-03
#13
Jonathan Draher, Norman White
A method for tryptophan (Trp) analysis designed to comply with AOAC Standard Method Performance Requirement 2014.013 is described. Unlike AOAC 988.15, which uses alkaline hydrolysis, this method uses enzymatic hydrolysis to release the Trp from the intact protein. The method achieves an LOQ of 0.18 mg/100 g Trp on a ready-to-feed basis with mean recoveries ranging from 93.8 to 104.9%. Repeatability ranged from 0.2 to 5.0%. Intermediate precision ranged from 1.0 to 6.9%. The analytical range was determined to be 0...
September 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28927485/novel-stability-indicating-chemometric-assisted-spectrophotometric-methods-for-the-determination-of-chlordiazepoxide-and-clidinium-bromide-in-the-presence-of-clidinium-bromide-s-alkali-induced-degradation-product
#14
Christine K Nessim, Adel M Michael, Yasmin M Fayez, Hayam M Lotfy
Two simple and accurate chemometric-assisted spectrophotometric models were developed and validated for the simultaneous determination of chlordiazepoxide (CDZ) and clidinium bromide (CDB) in the presence of an alkali-induced degradation product of CDB in their pure and pharmaceutical formulation. Resolution was accomplished by using two multivariate calibration models, including principal component regression (PCR) and partial least-squares (PLS), applied to the UV spectra of the mixtures. Great improvement in the predictive abilities of these multivariate calibrations was observed...
September 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28927376/systematic-review-of-statistical-approaches-to-quantify-or-correct-for-measurement-error-in-a-continuous-exposure-in-nutritional-epidemiology
#15
Derrick A Bennett, Denise Landry, Julian Little, Cosetta Minelli
BACKGROUND: Several statistical approaches have been proposed to assess and correct for exposure measurement error. We aimed to provide a critical overview of the most common approaches used in nutritional epidemiology. METHODS: MEDLINE, EMBASE, BIOSIS and CINAHL were searched for reports published in English up to May 2016 in order to ascertain studies that described methods aimed to quantify and/or correct for measurement error for a continuous exposure in nutritional epidemiology using a calibration study...
September 19, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28927166/experimental-evaluation-of-respirable-dust-and-crystalline-silica-controls-during-simulated-performance-of-stone-countertop-fabrication-tasks-with-powered-hand-tools
#16
David L Johnson, Margaret L Phillips, Chaolong Qi, Anthony T Van, Danielle A Hawley
Objectives: Workers who fabricate stone countertops using hand tools are at risk of silicosis from overexposure to respirable crystalline silica. This study explored the efficacy of simple engineering controls that can be used for dust suppression during use of hand tools by stone countertop fabricators. Methods: Controlled experiments were conducted to measure whether wet methods and on-tool local exhaust ventilation (LEV) reduced respirable dust (RD) exposures during use of various powered hand tools on quartz-rich engineered stone...
July 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28926582/selection-of-possible-signature-peptides-for-the-detection-of-bovine-lactoferrin-in-infant-formulas-by-lc-ms-ms
#17
Mingmei Yuan, Cong Feng, Shouyun Wang, Weiwei Zhang, Mo Chen, Hong Jiang, Xuesong Feng
An LC-MS/MS assay based on a signature peptide was developed and fully validated for the quantitation of bovine lactoferrin in infant formulas. Three unreported signature peptides were derived and identified from the tryptic peptides of bovine lactoferrin. The peptide ETTVFENLPEK was used for quantification based on assay performance. The blank matrix camel milk powder and bovine lactoferrin protein standards were mixed and spiked with stable isotope-labeled internal standard to establish a calibration curve...
2017: PloS One
https://www.readbyqxmd.com/read/28926581/imaging-grafted-cells-with-18f-fhbg-using-an-optimized-hsv1-tk-mammalian-expression-vector-in-a-brain-injury-rodent-model
#18
Anne-Sophie Salabert, Laurence Vaysse, Marie Beaurain, Mathieu Alonso, Germain Arribarat, Jean-Albert Lotterie, Isabelle Loubinoux, Mathieu Tafani, Pierre Payoux
INTRODUCTION: Cell transplantation is an innovative therapeutic approach after brain injury to compensate for tissue damage. To have real-time longitudinal monitoring of intracerebrally grafted cells, we explored the feasibility of a molecular imaging approach using thymidine kinase HSV1-TK gene encoding and [18F]FHBG as a reporter probe to image enzyme expression. METHODS: A stable neuronal cell line expressing HSV1-TK was developed with an optimised mammalian expression vector to ensure long-term transgene expression...
2017: PloS One
https://www.readbyqxmd.com/read/28926149/speciation-below-ground-tempo-and-mode-of-diversification-in-a-radiation-of-endogean-ground-beetles
#19
Carmelo Andújar, Sergio Pérez-González, Paula Arribas, Juan P Zaballos, Alfried P Vogler, Ignacio Ribera
Dispersal is a critical factor determining the spatial scale of speciation, which is constrained by the ecological characteristics and distribution of a species' habitat and the intrinsic traits of species. Endogean taxa are strongly affected by the unique qualities of the below-ground environment and its effect on dispersal, and contrasting reports indicate either high dispersal capabilities favoured by small body size and mediated by passive mechanisms, or low dispersal due to restricted movement and confinement inside the soil...
September 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28925981/a-new-first-break-picking-for-three-component-vsp-data-using-gesture-sensor-and-polarization-analysis
#20
Huailiang Li, Xianguo Tuo, Tong Shen, Ruili Wang, Jérémie Courtois, Minhao Yan
A new first break picking for three-component (3C) vertical seismic profiling (VSP) data is proposed to improve the estimation accuracy of first arrivals, which adopts gesture detection calibration and polarization analysis based on the eigenvalue of the covariance matrix. This study aims at addressing the problem that calibration is required for VSP data using the azimuth and dip angle of geophones, due to the direction of geophones being random when applied in a borehole, which will further lead to the first break picking possibly being unreliable...
September 19, 2017: Sensors
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