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https://www.readbyqxmd.com/read/29783197/quantification-of-21-antihypertensive-drugs-in-serum-using-uhplc-ms-ms
#1
Per Ole M Gundersen, Arne Helland, Olav Spigset, Solfrid Hegstad
BACKGROUND: Poor drug adherence in hypertensive patients can lead to treatment failure and increased cardiovascular morbidity, as well as increased costs to society. An analytical method based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MSMS) was developed and validated for use in routine therapeutic drug monitoring (TDM). The method includes 21 antihypertensive drugs or active metabolites from the groups beta blockers (n=5), calcium antagonists (n=5), angiotensin II receptor antagonists (n=4), angiotensin converting enzyme (ACE) inhibitors (n=3) and diuretics (n = 3), in addition to one α1-selective alpha blocker...
April 28, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29783173/development-and-validation-of-an-analytical-method-for-regorafenib-and-its-metabolites-in-mouse-plasma
#2
Qiang Fu, Mingqing Chen, Shuiying Hu, Craig A McElroy, Ron H Mathijssen, Alex Sparreboom, Sharyn D Baker
An analytical method was developed for measuring the effect of OATP1B2 deficiency on plasma levels of the kinase inhibitor regorafenib and its metabolites regorafenib-N-oxide, N-desmethyl-regorafenib-N-oxide, and regorafenib-N-β-glucuronide (RG) in mice. Compounds were separated by liquid chromatography and monitored by a triple quadrupole mass spectrometer in the selected reaction monitoring mode after positive electrospray ionization. All calibration curves were linear in the selected concentration range (R2  ≥ 0...
May 5, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29783168/fluorescence-probes-for-real-time-remote-cyanobacteria-monitoring-a-review-of-challenges-and-opportunities
#3
REVIEW
Edoardo Bertone, Michele A Burford, David P Hamilton
In recent years, there has been a widespread deployment of submersible fluorescence sensors by water utilities. They are used to measure diagnostic pigments and estimate algae and cyanobacteria abundance in near real-time. Despite being useful and promising tools, operators and decision-makers often rely on the data provided by these probes without a full understanding of their limitations. As a result, this may lead to wrong and misleading estimations which, in turn, means that researchers and technicians distrust these sensors...
May 10, 2018: Water Research
https://www.readbyqxmd.com/read/29783148/comparative-study-of-six-sequential-spectrophotometric-methods-for-quantification-and-separation-of-ribavirin-sofosbuvir-and-daclatasvir-an-application-on-laboratory-prepared-mixture-pharmaceutical-preparations-spiked-human-urine-spiked-human-plasma-and-dissolution
#4
Wafaa S Hassan, Manal S Elmasry, Heba M Elsayed, Dalia W Zidan
In accordance with International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, six novel, simple and precise sequential spectrophotometric methods were developed and validated for the simultaneous analysis of Ribavirin (RIB), Sofosbuvir (SOF), and Daclatasvir (DAC) in their mixture without prior separation steps. These drugs are described as co-administered for treatment of Hepatitis C virus (HCV). HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma) and lymphomas in humans...
May 18, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29783145/electrochemical-biosensor-system-using-a-cmos-microelectrode-array-provides-high-spatially-and-temporally-resolved-images
#5
William Tedjo, Jasmine E Nejad, Rachel Feeny, Lang Yang, Charles S Henry, Stuart Tobet, Tom Chen
The ability to view biological events in real time has contributed significantly to research in the life sciences. While video capture of real time changes in anatomical relationships is important, it is equally important to visualize real time changes in the chemical communications that drive cell behaviors. This paper describes an electrochemical imaging system capable of capturing changes in chemical gradients in live tissue slices. The system consists of a CMOS microchip with 8192 configurable Pt surface electrodes, on-chip potentiostat, on-chip control logic, and a microfluidic device designed to interface with the CMOS chip to support ex vivo tissue experimentation...
April 10, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29783069/association-between-the-rs1143634-polymorphism-in-interleukin-1b-and-chronic-periodontitis-results-from-a-meta-analysis-composed-by-54-case-control-studies
#6
REVIEW
Felipe Rodolfo Pereira da Silva, Any Carolina Cardoso Guimarães Vasconcelos, Luiz Felipe de Carvalho França, David Di Lenardo, Hélio Mateus Silva Nascimento, Daniel Fernando Pereira Vasconcelos
Several factors are involved in the periodontitis with host response through cytokines and as well as with influence of polymorphisms in cytokine genes, however the results remained contradictory. This study aimed at evaluating the rs1143634 polymorphism in interleukin-1B gene, a cytokine gene, and the risk of chronic periodontitis with conducting a meta-analysis focusing in ethnicity. A review in literature was performed in several databases to studies published before June 2017. Data extraction was performed by two calibrated investigators and the calculations of the meta-analysis were obtained through Review Manager version 5...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29782522/molecular-detection-of-mycobacterium-ulcerans-in-the-environment-and-its-relationship-with-buruli-ulcer-occurrence-in-zio-and-yoto-districts-of-maritime-region-in-togo
#7
Issaka Maman, Tchadjobo Tchacondo, Abiba Banla Kere, Marcus Beissner, Kossi Badziklou, Ekanao Tedihou, Edith Nyaku, Komi Amekuse, Franz Xaver Wiedemann, Damintoti Simplice Karou, Gisela Bretzel
BACKGROUND: Buruli Ulcer (BU) is a neglected tropical skin infection caused by Mycobacterium ulcerans. Residence near aquatic areas has been identified as an important source of transmission of M. ulcerans with increased risk of contracting Buruli ulcer. However, the reservoir and the mode of transmission are not yet well known. The aim of this study was to identify the presence of M. ulcerans in the environment and its relationship with Buruli ulcer occurrence in Zio and Yoto districts of the maritime region in south Togo...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29782500/the-human-snail-transmission-environment-shapes-long-term-schistosomiasis-control-outcomes-implications-for-improving-the-accuracy-of-predictive-modeling
#8
David Gurarie, Nathan C Lo, Martial L Ndeffo-Mbah, David P Durham, Charles H King
INTRODUCTION: Schistosomiasis is a chronic parasitic trematode disease that affects over 240 million people worldwide. The Schistosoma lifecycle is complex, involving transmission via specific intermediate-host freshwater snails. Predictive mathematical models of Schistosoma transmission have often chosen to simplify or ignore the details of environmental human-snail interaction in their analyses. Schistosome transmission models now aim to provide better precision for policy planning of elimination of transmission...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29782221/effect-of-surface-sealant-reapplication-on-clinical-performance-of-hema-containing-and-hema-free-self-etch-adhesives-two-year-results
#9
N Tekçe, M Demirci, S Tuncer, S A Göktürk
PURPOSE: To evaluate the clinical performance of one-step self-etch adhesives over two years with and without the application of a surface sealant. METHODS AND MATERIALS: In total, 160 restorations in 40 patients were performed for occlusal caries. Each patient received four Class I restorations, which included a 2-hydroxyethyl methacrylate (HEMA)-containing (Clearfil S3 Bond) and HEMA-free (G-aenial Bond) one-step self-etch adhesive system with and without surface sealant...
May 21, 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29781998/making-testing-and-using-potassium-ion-selective-microelectrodes-in-tissue-slices-of-adult-brain
#10
J Christopher Octeau, Guido Faas, Istvan Mody, Baljit S Khakh
Potassium ions significantly contribute to the resting membrane potential of cells and, therefore, extracellular K+ concentration is a crucial regulator of cell excitability. Altered concentrations of extracellular K+ affect the resting membrane potential and cellular excitability by shifting the equilibria between closed, open and inactivated states for voltage-dependent ion channels that underlie action potential initiation and conduction. Hence, it is valuable to directly measure extracellular K+ dynamics in health and diseased states...
May 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781645/sex-differences-in-emotion-recognition-evidence-for-a-small-overall-female-superiority-on-facial-disgust
#11
Hannah L Connolly, Carmen E Lefevre, Andrew W Young, Gary J Lewis
Although it is widely believed that females outperform males in the ability to recognize other people's emotions, this conclusion is not well supported by the extant literature. The current study sought to provide a strong test of the female superiority hypothesis by investigating sex differences in emotion recognition for five basic emotions using stimuli well-calibrated for individual differences assessment, across two expressive domains (face and body), and in a large sample (N = 1,022: Study 1). We also assessed the stability and generalizability of our findings with two independent replication samples (N = 303: Study 2, N = 634: Study 3)...
May 21, 2018: Emotion
https://www.readbyqxmd.com/read/29781480/polydisperse-emulsion-digital-assay-to-enhance-time-to-detection-and-extend-dynamic-range-in-bacterial-cultures-enabled-by-a-statistical-framework
#12
Samantha A Byrnes, Elizabeth A Phillips, Toan Huynh, Bernhard H Weigl, Kevin P Nichols
Microbiological culture remains the most sensitive method for detecting viable and infectious bacteria, but these methods often require at least 24 hours to visibly identify bacterial growth. Lab-on-a-chip applications have utilized methods to isolate bacteria in picoliter-sized reaction vessels, resulting in digitized signals that offer improved time-to-detection and improved quantification. Although a great improvement, these approaches typically require expensive and specialized equipment, trained laboratory personnel, and maximum addressable volumes that can be orders of magnitude less than needed for clinically relevant limits of detection...
May 21, 2018: Analyst
https://www.readbyqxmd.com/read/29781236/detection-of-acetyltransferase-modification-of-kanamycin-an-aminoglycoside-antibiotic-in-bacteria-using-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#13
Johnny J Perez, Chin-Yi Chen
RATIONALE: The occurrence of antibiotic resistant (AR) bacteria is a worldwide issue that has the potential, if not addressed, to eliminate classes of antibiotics that have extended life expectancy in the last century. An approach to confront this threat is the development of technologies that greatly accelerate the detection of AR to minimize unnecessary treatment involving antibiotics. Development of an analytical method for rapid detection of aminoglycoside resistance using liquid chromatography mass spectrometry (LC-MS) has not been reported in literature and is described here...
May 20, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29781207/modelling-the-impact-of-a-national-scale-up-of-interventions-on-hepatitis-c-virus-transmission-among-people-who-inject-drugs-in-scotland
#14
H Fraser, C Mukandavire, N K Martin, D Goldberg, N Palmateer, A Munro, A Taylor, M Hickman, S Hutchinson, P Vickerman
BACKGROUND AND AIMS: To reduce hepatitis C virus (HCV) transmission among people who inject drugs (PWID), Scottish Government-funded national strategies, launched in 2008, promoted scaling-up opioid substitution therapy (OST) and needle and syringe provision (NSP), with some increases in HCV treatment. We test whether observed decreases in HCV incidence post-2008 can be attributed to this intervention scale-up. DESIGN: A dynamic HCV transmission model amongst PWID incorporating intervention scale-up and observed decreases in behavioural risk, calibrated to Scottish HCV prevalence and incidence data for 2008/09...
May 20, 2018: Addiction
https://www.readbyqxmd.com/read/29780627/a-new-approach-to-predict-lymph-node-metastasis-in-solid-lung-adenocarcinoma-a-radiomics-nomogram
#15
Xinguan Yang, Xiaohuan Pan, Hui Liu, Dashan Gao, Jianxing He, Wenhua Liang, Yubao Guan
Background: Lymph node metastasis (LNM) of lung cancer is an important factor related to survival and recurrence. The association between radiomics features of lung cancer and LNM remains unclear. We developed and validated a radiomics nomogram to predict LNM in solid lung adenocarcinoma. Methods: A total of 159 eligible patients with solid lung adenocarcinoma were divided into training (n=106) and validation cohorts (n=53). Radiomics features were extracted from venous-phase CT images...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29780445/a-comparison-of-simulated-and-field-derived-leaf-area-index-lai-and-canopy-height-values-from-four-forest-complexes-in-the-southeastern-usa
#16
John S Iiames, Ellen Cooter, Donna Schwede, Jimmy Williams
Vegetative leaf area is a critical input to models that simulate human and ecosystem exposure to atmospheric pollutants. Leaf area index (LAI) can be measured in the field or numerically simulated, but all contain some inherent uncertainty that is passed to the exposure assessments that use them. LAI estimates for minimally managed or natural forest stands can be particularly difficult to develop as a result of interspecies competition, age and spatial distribution. Satellite-based LAI estimates hold promise for retrospective analyses, but we must continue to rely on numerical models for alternative management analysis...
2018: Forests
https://www.readbyqxmd.com/read/29780283/adaptation-and-application-of-multivariate-ambi-m-ambi-in-us-coastal-waters
#17
Marguerite C Pelletier, David J Gillett, Anna Hamilton, Treda Grayson, Virginia Hansen, Erik W Leppo, Stephan B Weisberg, Angel Borja
The multivariate AMBI (M-AMBI) is an extension of the AZTI Marine Biotic Index (AMBI) that has been used extensively in Europe, but not in the United States. In a previous study, we adapted AMBI for use in US coastal waters (US AMBI), but saw biases in salinity and score distribution when compared to locally calibrated indices. In this study we modified M-AMBI for US waters and compared its performance to that of US AMBI. Index performance was evaluated in three ways: 1) concordance with local indices presently being used as management tools in three geographic regions of US coastal waters, 2) classification accuracy for sites defined a priori as good or bad and 3) insensitivity to natural environmental gradients...
June 1, 2018: Ecological Indicators
https://www.readbyqxmd.com/read/29780255/predicting-initial-margin-status-in-breast-cancer-patients-during-breast-conserving-surgery
#18
Zihao Pan, Liling Zhu, Qian Li, Jianguo Lai, Jingwen Peng, Fengxi Su, Shunrong Li, Kai Chen
Background: We sought to develop and validate a model for prediction of initial margin status during breast-conserving surgery (BCS). Methods: We included eligible breast cancer patients receiving BCS in Sun Yat-sen Memorial Hospital from January 2003 to December 2014. All patients received intraoperative frozen-section analysis for initial margin assessment. We used univariate and multivariate logistic regression analyses to screen for predictors. A nomogram was developed in the training cohort (n=1,193) from the south branch of the hospital and externally validated in the validation cohort (n=499) from the north branch...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29780170/model-selection-theory-the-need-for-a-more-nuanced-picture-of-use-novelty-and-double-counting
#19
Katie Steele, Charlotte Werndl
This article argues that common intuitions regarding (a) the specialness of 'use-novel' data for confirmation and (b) that this specialness implies the 'no-double-counting rule', which says that data used in 'constructing' (calibrating) a model cannot also play a role in confirming the model's predictions, are too crude. The intuitions in question are pertinent in all the sciences, but we appeal to a climate science case study to illustrate what is at stake. Our strategy is to analyse the intuitive claims in light of prominent accounts of confirmation of model predictions...
June 2018: British Journal for the Philosophy of Science
https://www.readbyqxmd.com/read/29780048/-separated-calibration-of-radiotherapy-dosimeter
#20
Morihito Shimizu
No abstract text is available yet for this article.
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
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