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https://www.readbyqxmd.com/read/28407313/prognosis-of-primary-tracheal-tumor-a-population-based-analysis
#1
Jiaxi He, Jianfei Shen, Jun Huang, Chenyang Dai, Wenhua Liang, Minhua Ye, Min Kong, Baofu Chen, Chengchu Zhu, Jianxing He
BACKGROUND: To elucidate the survival outcomes of tracheal tumors and to propose the potential stage of tracheal tumors. METHOD: All cases of primary tracheal malignant tumors were extracted from the Surveillance, Epidemiology, and End Results database (SEER) during 1973-2013. The overall survival was calculated using Kaplan-Meier method. Cox regression was utilized to identify the prognostic factors. RESULT: A total of 287 cases were finally included...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28393719/a-case-of-tracheal-leiomyoma-misdiagnosed-as-asthma
#2
Ayperi Öztürk, Zafer Aktaş, Aydın Yılmaz, Havva Yeşildağlı, Leyla Memiş
Primary benign tumors of trachea are rare. Of them, tracheal leiomyoma, constitutes only 1% of all benign lower respiratory tract tumors. Here, we present a case of tracheal leiomyoma who has been receiving high doses of inhaled corticosteroids and bronchodilators for a year with a misdiagnosis of asthma. As the symptoms did not resolve with an overtreatment, she has been undergone radiologic study to find a possible alternative diagnosis. The chest roentgenogram revealed an opacity in the upper mediastinum...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28389860/a-novel-self-expandable-radioactive-airway-stent-loaded-with-125-i-seeds-a-feasibility-and-safety-study-in-healthy-beagle-dog
#3
Yong Wang, Jin-He Guo, Guang-Yu Zhu, Hai-Dong Zhu, Li Chen, Jian Lu, Chao Wang, Gao-Jun Teng
PURPOSE: Airway stent placement is an effective treatment for the immediate palliation of malignant airway obstruction. However, restenosis caused by tumor ingrowth and/or overgrowth after stenting is common. The purpose of this study was to investigate the feasibility and safety of a novel self-expandable stent loaded with (125)I seeds in healthy beagle dog. MATERIALS AND METHODS: Under fluoroscopic guidance, forty-eight self-expandable airway stents loaded with (125)I seeds were perorally placed in the main trachea of 48 healthy beagle dogs, who were randomly divided into four groups (Group A: 0...
April 7, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28373918/successful-treatment-of-carcinomatous-central-airway-obstruction-with-bronchoscopic-electrocautery-using-hot-biopsy-forceps-during-mechanical-ventilation
#4
Motoi Ugajin, Hisanori Kani
We report the case of a 72-year-old man with occlusion of the left main bronchus due to squamous cell carcinoma of the lung. He required tracheal intubation and mechanical ventilation because of the aggravation of atelectasis and obstructive pneumonia. Electrocautery using hot biopsy forceps was performed during mechanical ventilation with a 40% fraction of inspired oxygen. He was extubated following improvement in the atelectasis and obstructive pneumonia and discharged with shrinkage of the tumor after chemotherapy...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28366144/-a-case-of-tracheal-leiomyoma-misdiagnosed-as-asthma
#5
Ayperi Öztürk, Zafer Aktaş, Aydın Yılmaz, Havva Yeşildağlı, Leyla Memiş
Primary benign tumors of trachea are rare. Of them, tracheal leiomyoma, constitutes only 1% of all benign lower respiratory tract tumors. Here, we present a case of tracheal leiomyoma who has been receiving high doses of inhaled corticosteroids and bronchodilators for a year with a misdiagnosis of asthma. As the symptoms did not resolve with an overtreatment, she has been undergone radiologic study to find a possible alternative diagnosis. The chest roentgenogram revealed an opacity in the upper mediastinum...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28365508/in-vitro-the-differences-of-inflammatory-and-oxidative-reactions-due-to-sulfur-mustard-induced-acute-pulmonary-injury-underlying-intraperitoneal-injection-and-intratracheal-instillation-in-rats
#6
Dan Yu, Yuan-Yuan Bei, Yuan Li, Wei Han, Yu-Xu Zhong, Fei Liu, Yu-Ling Zhao, Xiao-Ji Zhu, Jian Zhao
This study was to investigate the differences of inflammatory reaction and oxidative stress due to sulfur mustard (SM)-induced acute pulmonary injury via two ways in rats. In intraperitoneal and tracheal SM groups, injected intraperitoneally and instilled intratracheally with 0.1mL diluted SM (0.96 LD50=8mg/kg) and SM (0.98 LD50=2mg/kg) were administered in rats. In bronchoalveolar lavage fluid, serum, and alveolar septum, lactate dehydrogenase, glutathione peroxidase, tumor necrosis factor-α, interleukin-1β, interleukin-6, C-reactive protein, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, l-selectin, r-glutamyl transpeptidase, thiobarbituric acid reactive substances levels as well as the expression of CD4, CD20, CD68, 8-hydroxy deoxyguanosine, nuclear factor-E2-related factor 2, and heme oxygenase-1 measured by ELISA, immune scatter turbidimetry and immunohistochemical method in the intraperitoneal SM group were increased at each time-point compared with the tracheal SM groups, respectively...
March 30, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28301584/diagnostic-accuracy-and-added-value-of-dual-energy-subtraction-radiography-compared-to-standard-conventional-radiography-using-computed-tomography-as-standard-of-reference
#7
Katharina Martini, Marco Baessler, Stephan Baumueller, Thomas Frauenfelder
PURPOSE: To retrospectively evaluate diagnostic performance of dual-energy subtraction radiography (DESR) for interpretation of chest radiographs compared to conventional radiography (CR) using computed tomography (CT) as standard of reference. MATERIAL AND METHODS: A total of 199 patients (75 female, median age 67) were included in this institutional review board (IRB)-approved clinical trial. All patients were scanned in posteroanterior and lateral direction with dual-shot DE-technique...
2017: PloS One
https://www.readbyqxmd.com/read/28294664/-a-giant-inflammatory-fibroid-polyp-of-the-esophagus
#8
Balázs Vincze, Péter Mezei, János Hanyik, Sándor Almássy, Károly Gyáni, Géza Szűcs, Imre Tóth
Inflammatory fibroid polyp (IFP) is an uncommon benign tumor of the gastrointestinal tract. IFP in the esophagus is very rare, in particular in giant size. A case of a 63 year old woman with a 13 × 7 × 4.5 cm polyp originated of the lower third of the oesophagus is presented. Her esophageal polyp extended proximally from the level of the tracheal bifurcation, prolapsing through the cardia as well as the herniated stomach, and entered distally into the abdominal part of the stomach. Resection of the polyp was performed via a right oesophago-gastrotomy...
March 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28263419/transoral-ultrasonic-surgery-of-pharyngolaryngeal-giant-hemangioma-after-ethylene-vinyl-alcohol-copolymer-onyx-embolization
#9
Meritxell Valls-Mateus, Luis San Román, Juan Macho, Alfons Nadal, Manuel Bernal-Sprekelsen, Isabel Vilaseca
BACKGROUND: Cervico-mediastinal hemangiomas in adulthood are rare and slow-growing vascular tumors. The optimal treatment for giant hemangiomas is controversial. In asymptomatic cases, clinical observation is generally recommended. METHODS: We report the transoral resection of a pharyngolaryngeal hemangioma (diameters of 44 × 56 × 39 mm) with tracheal involvement and mediastinal extension. Clinically, the patient had throat foreign body sensation, severe dyspnea and stridor...
March 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28255381/can-endobronchial-or-endotracheal-metastases-appear-from-rectal-adenocarcinoma
#10
G L Serbanescu, R M Anghel
Background: Endobronchial and endotracheal metastases from extra-pulmonary solid tumors are rare. Patients and methods: We reported the case of a patient diagnosed with endobronchial and endotracheal metastases from rectal adenocarcinoma. Case report: Patient P.G., 62 years old, was diagnosed with a rectal tumor in 2011, for which, a surgical intervention was performed (pT3 pN2a M0, stage IIIB). Afterwards, she underwent adjuvant chemotherapy and concomitant radiochemotherapy. In September 2013, the chest CT showed 2 nodules for which, an incomplete surgical resection was done and which were histopathologically diagnosed as metastases from rectal cancer...
January 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28249616/tumor-to-tumor-metastases-papillary-thyroid-carcinoma-into-a-clear-cell-renal-cell-carcinoma
#11
Jin Soo Andy Song, S Mark Taylor, Jonathan Trites, Matthew H Rigby, Martin Joseph Bullock, Jennifer Merrimen, Ricardo Rendon, Robert D Hart
BACKGROUND: Thyroid metastases to distant sites are uncommon incidents, most often metastasizing to the lungs and bones. Rates of metastasis to the kidney are particularly low, ranging from 2.8-3.8% for papillary and 6-20% for follicular variants of well-differentiated thyroid cancers (WDTCs). In rare instances, tumor-to-tumor metastasis between two true primary neoplasms can occurs. This medical phenomenon has previously occurred as a clear cell renal cell carcinoma (CCRCC) spreading to a WDTC...
March 1, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28225857/malignant-melanoma-with-synchronous-thyroid-metastases-case-report-and-literature-review
#12
Maria Manuel Costa, Sandra Belo, João Capela-Costa, Jennifer Costa, Davide Carvalho
Thyroid metastases are rare in clinical practice. We describe the case of an 85-year-old woman who was referred to our department due to a multinodular goiter with compressive symptoms and subclinical hyperthyroidism. The patient was also undergoing evaluation for a polyp in her left nasal cavity, which was then diagnosed as a malignant melanoma of the nasal mucosa. A thoracoabdominal magnetic resonance imaging obtained for cancer staging revealed a > 50% tracheal obstruction caused by the goiter. The patient underwent simultaneous total thyroidectomy and melanoma excision...
February 16, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28192751/ameliorative-potential-of-linagliptin-and-or-calcipotriol-on-bleomycin-induced-lung-fibrosis-in-vivo-and-in-vitro-study
#13
Ahmed M Kabel, Maaly A Abd Elmaaboud, Aliaa Atef, Mohammed H Baali
Pulmonary fibrosis is a serious medical problem that may significantly compromise respiratory functions. The aim of this work was to study the effect of linagliptin and/or calcipotriol on bleomycin-induced pulmonary fibrosis and to explore the possible mechanisms underlying this effect. One hundred and twenty male C57BL/6 mice were divided into 6 equal groups as follows: control group; bleomycin group; bleomycin+carboxymethylcellulose group; bleomycin+linagliptin group; bleomycin+calcipotriol group and bleomycin+linagliptin+calcipotriol group...
March 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28149577/tracheal-and-bronchial-tumors
#14
REVIEW
Patricio Varela, Luca Pio, Elisa Brandigi, Irene Paraboschi, Nazhia Khen-Dunlop, Erik Hervieux, Cecile Muller, Girolamo Mattioli, Sabine Sarnacki, Michele Torre
Although primary tracheobronchial tumors are extremely rare in children, recurrent respiratory symptoms resistant to conventional therapy require further investigations to exclude possible malignant obstructive causes. As the matter of fact, early diagnosis may allow minimally invasive surgeries, improving the standard of living and the globally survival rate. The aim of this article is to provide an overview of diagnosis and management of tracheobronchial tumors in the early age, since only few reports are reported in the worldwide literature...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28133561/thoracoscopic-surgery-for-glomus-tumor-an-uncommon-mediastinal-neoplasm-and-iatrogenic-tracheal-rupture
#15
Zhongjie Fang, Dehua Ma, Baofu Chen, Huarong Luo
Mediastinal glomus tumors are rarely recognized, and only seven cases have been reported in the literature. Here, we describe a rare mediastinal glomus tumor and review the characteristics of this rare clinical case. The patient was a 50-year-old female who presented with coughing for 3 months. Her chest computed tomography scan demonstrated a localized tumor in the posterior superior mediastinum. Intraoperatively, we found a longitudinal rupture of the membranous trachea above the carina. We completely resected the tumor and repaired the tracheal rupture under a thoracoscopy using a pedicled muscle flap...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28133204/-salvage-surgery-after-crt-for-advanced-esophageal-cancer-resulting-in-a-pathological-complete-response-and-more-than-five-years-survival
#16
Sachiko Kaida, Satoshi Murata, Tsuyoshi Yamaguchi, Reiko Ohtake, Katsushi Takebayashi, Hiroshi Yamamoto, Tomoyuki Ueki, Toru Miyake, Hiroya Iida, Hiroya Akabori, Hiromichi Sonoda, Tsuyoshi Mori, Tomoharu Shimizu, Shigeyuki Naka, Masaji Tani
A 62-year-old woman visited our hospital because of dysphagia. She was diagnosed with upper-middle esophageal type 4 cancer, which was 9 cm in length, according to the results of endoscopy. Squamous cell carcinoma was demonstrated using endoscopic biopsy. A CT scan revealed that the tumor had directly invaded into the trachea(cT4). Chemoradiotherapy(CRT) (5-FU and CDDP with 50 Gy of radiation)was administered. Although CT after CRT resulted in shrinkage of the tumor and no further tracheal invasion, esophageal stenosis remained...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28109369/successful-treatment-of-an-aggressive-tracheal-malignancy-with-immunotherapy
#17
Asishana A Osho, Christopher J Azzoli, Sara Pai, Mari Mino-Kenudson, William C Faquin, Tiffany G Huynh, Michael Lanuti, Douglas J Mathisen, Ashok Muniappan
Immune checkpoint inhibitors are emerging as therapeutic options for oncology patients in whom conventional treatment regimens have failed. These immunotherapies counteract tumor-induced tolerance and have been shown to be effective in thoracic malignancies, including non-small cell lung cancer (NSCLC). This report highlights the successful use of nivolumab-an immunotherapeutic agent that binds to proteins involved in T-cell proliferation-for the management of recurrent tracheal squamous cell cancer after exhaustion of conventional surgical, chemotherapeutic, and radiation therapy options...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28088789/gprc5a-knockout-mouse-lung-epithelial-cells-predicts-ceruloplasmin-lipocalin-2-and-periostin-as-potential-biomarkers-at-early-stages-of-lung-tumorigenesis
#18
Beibei Sun, Wenzheng Guo, Song Hu, Feng Yao, Keke Yu, Jie Xing, Ronghua Wang, Hongyong Song, Yueling Liao, Tong Wang, Pengfei Jiang, Baohui Han, Jiong Deng
Lung cancer is the leading cause of cancer death. As most of lung cancer patients were diagnosed with the advanced stage, early detection is considered as the most effective strategy to reduce high mortality. Thus, it is desirable to identify specific biomarkers at early stages of lung tumorigenesis. GPRC5A is a lung tumor suppressor gene. GPRC5A deficiency is linked to lung cancer development. We hyposthesized that, dysregulated gene expression that results from Gprc5a deficiency may provide potential biomarkers at early stages of lung tumorigenesis...
February 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28066620/tracheobronchial-tumors
#19
REVIEW
Ruza Stevic, Branislava Milenkovic
Tumors of trachea and bronchi are uncommon and can occur in the form of benign or low- and high-grade malignant tumors. Although tracheobronchial tumors (TBTs) represent only 0.6% of all pulmonary tumors, they are clinically significant. Delays in diagnosis of these tumors commonly occur because the signs and symptoms caused by these tumors are nonspecific and chest radiographs are often considered unremarkable. Therefore, novel radiological techniques and better access to flexible bronchoscopy enable detection of larger number of TBT...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28039009/percutaneous-ct-fluoroscopic-guided-radioisotope-seed-placement-for-the-management-of-adenoid-cystic-carcinoma-of-the-trachea
#20
Stephen Doggett, Shigeru Chino, Todd Lempert, Jay Federhart
PURPOSE: Tracheal and paratracheal malignancies present challenges in radiotherapeutic management due to their proximity to sensitive structures, central location, and because of the potential for catastrophic radiation induced fistula. The use of external beam radiation therapy and intraluminal brachytherapy has a limited number of reports in the literature. We have searched for a technique for treating tracheal and paratracheal malignancies allowing application of a high dose of radiation while minimizing dose to normal tissues...
December 27, 2016: Brachytherapy
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