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https://www.readbyqxmd.com/read/29322405/combining-cell-type-restricted-adenoviral-targeting-with-immunostaining-and-flow-cytometry-to-identify-cells-of-origin-of-lung-cancer
#1
Sarah A Best, Ariena Kersbergen, Marie-Liesse Asselin-Labat, Kate D Sutherland
Lung cancers display considerable intertumoral heterogeneity, leading to the classification of distinct tumor subtypes. Our understanding of the genetic aberrations that underlie tumor subtypes has been greatly enhanced by recent genomic sequencing studies and state-of-the-art gene targeting technologies, highlighting evidence that distinct lung cancer subtypes may be derived from different "cells-of-origin". Here, we describe the intra-tracheal delivery of cell type-restricted Ad5-Cre viruses into the lungs of adult mice, combined with immunohistochemical and flow cytometry strategies for the detection of lung cancer-initiating cells in vivo...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29319034/the-mimic-of-tracheal-carcinoid-in-elderly-female
#2
Parth Rali, Namrata Jasani, Hammad Arshad, Jianwu Xie, Marvin Balaan
We present a case of a glomus tumor of trachea in an elderly female who presented with a mass originating from the posterior trachea. She underwent rigid bronchoscopy with tumor debulking combined with laser therapy. Frozen section initially suggested carcinoid tumor but later turned out to be a glomus tumor. She improved with additional laser therapy. We present her clinical course and a literature review on glomus tumor.
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29308750/-changes-in-circulating-microparticles-in-mice-with-ventilator-induced-lung-injury
#3
Yingjie Yin, Shouqin Zhang, Sanqiang Wang, Hu Long, Chengjin Gao, Xiangyu Zhang
OBJECTIVE: To investigate the changes in serum level of microparticles (EMPs) in mice with ventilator-induced lung injury (VILI), and explore its significance in VILI. METHODS: Forty-eight grade SPF male C57BL/6J mice were randomly divided into two groups, with 24 mice in each group: the mice in mechanical ventilation (MV) group were given high tidal volume (VT 30 mL/kg) MV for 4 hours after tracheal intubation, and those in spontaneous breathing group were spontaneously breathed for 4 hours...
January 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29305634/-thoracic-inflammatory-pseudotumors-a%C3%A2-rare-differential-diagnosis
#4
S Sponholz, M Schirren, N Baldes, L Schreiner, A Fisseler-Eckhoff, J Schirren
BACKGROUND: Inflammatory pseudotumors are a rare and in the main benign tumor entity but infiltrative growth, recurrence and metastases are described. Generally, a complete resection is needed to exclude lung cancer. This study analyzed our data and experiences with this rare tumor entity. MATERIAL AND METHODS: We performed a retrospective study of all our patients who had been operated on between 2002 and 2016 in our institution for an inflammatory pseudotumor of the lungs...
January 5, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29202770/a-10-year-clinical-outcome-of-radiotherapy-as-an-adjuvant-or-definitive-treatment-for-primary-tracheal-adenoid-cystic-carcinoma
#5
Hyoung Uk Je, Si Yeol Song, Dong Kwan Kim, Yong-Hee Kim, Seong-Yun Jeong, Geum Mun Back, Wonsik Choi, Su Ssan Kim, Seung-Il Park, Eun Kyung Choi
BACKGROUND: To evaluate the role of radiotherapy (RT) as an adjuvant or definitive treatment in primary tracheal adenoid cystic carcinoma (ACC) for local tumor control and survival. METHODS: A retrospective chart review was performed in 22 patients treated with adjuvant or definitive RT for primary tracheal ACC at a single center between November 1994 and December 2008. RESULTS: Thirteen and 9 patients received adjuvant and definitive RT, respectively...
December 4, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29183345/primary-tracheal-schwannoma-a-review-of-a-rare-entity-current-understanding-of-management-and-followup
#6
Shadi Hamouri, Nathan M Novotny
BACKGROUND: Neurogenic tumors of the tracheobronchial tree are extremely rare and include neurofibroma and schwannoma. We report a case of primary recurrent tracheal schwannoma causing obstructive airway symptoms. CASE PRESENTATION: A 60-year-old man presented with obstructive airway symptoms due to recurrent tracheal schwannoma. Due the recurrence, size of the tumor and low surgical risk, the patient was treated with tracheal resection. CONCLUSION: Primary endotracheal neurogenic tumors are extremely rare, but one should consider them in the differential diagnosis of persistent upper airway symptoms...
November 28, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29142850/complications-from-tracheal-resection-for-thyroid-carcinoma
#7
REVIEW
Nicola Rotolo, Maria Cattoni, Andrea Imperatori
Thyroidectomy associated to en bloc tracheal resection with end-to-end anastomosis is the treatment of choice of thyroid tumor invading the tracheal wall and is associated with a good prognosis. However, the postoperative morbidity is not irrelevant. The present review aims to discuss the complications occurring after this aggressive surgical procedure. The search was performed using PubMed through an overarching for the following terms: "complication of tracheal resection [AND] invasive thyroid cancer". Postoperative complications rate after tracheal sleeve resection with end-to-end anastomosis for thyroid cancer invading tracheal wall range from 15% to 39%...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29137052/arytenoid-cartilage-dislocation-mimicking-bilateral-vocal-cord-paralysis-a-case-report
#8
Eun H Chun, Hee J Baik, Rack K Chung, Hun J Lee, Kwangseob Shin, Jae H Woo
RATIONALE: Arytenoid dislocation is very rare and may be misdiagnosed as vocal cord paralysis or a self-limiting sore throat. PATIENT CONCERNS: A 70-year-old male (70 kg, 156 cm) was scheduled for transurethral resection of bladder tumors. A McGrath videolaryngoscope, with a basic cuffed Mallinckrodt oral tracheal tube of 7.5 mm internal diameter, was used to successfully intubate his trachea. The duration of surgery was 25 minutes. In the recovery room, he complained of sore throat and dyspnea with inspiratory stridor, which were not resolved after intravenous injection of 10 mg of dexamethasone...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29124061/diagnostics-of-thyroid-malignancy-and-indications-for-surgery-in-the-elderly-and-younger-counterparts-comparison-of-3-749-patients
#9
Krzysztof Kaliszewski, Dorota Diakowska, Marta Strutyńska-Karpińska, Beata Wojtczak, Michał Aporowicz, Zdzisław Forkasiewicz, Waldemar Balcerzak, Tadeusz Łukieńczuk, Paweł Domosławski
Background: It seems valuable for clinicians to know if diagnostics of thyroid malignancy (TM) and indications for surgery in the elderly patients differ from these in younger counterparts. Materials and Methods: Retrospective analysis of the medical records of 3,749 patients surgically treated for thyroid tumor. Data of patients with histopathology confirmed TM (n = 309) were studied. Results: The rate of cytological prediction to malignancy was more than three times higher in elderly women...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29113553/individualizing-surgery-in-papillary-thyroid-carcinoma-based-on-a-detailed-sonographic-assessment-of-extrathyroidal-extension
#10
Eric James Kuo, William J Thi, Feibi Zheng, Kyle Zanocco, Masha J Livhits, Michael W Yeh
BACKGROUND: Lobectomy may be sufficient for patients with intrathyroidal papillary thyroid carcinomas (PTC) < 4 cm without nodal metastasis. Based on the 2015 American Thyroid Association guidelines, a strategy using ultrasound to identify appropriate candidates for lobectomy was implemented. METHODS: We retrospectively reviewed patients with Bethesda V or VI cytology who underwent surgery for PTC (January 2016 to May 2017). Eligibility for lobectomy was based both tumor (unilateral, intrathyroidal tumors ≤ 3 cm in size) and non-tumor (history of hypothyroidism, radiation exposure, etc...
November 7, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29067926/rare-tracheal-tumor-solitary-plasmacytoma
#11
R Stevic, M Ercegovac, J Stojšić, N Čolić
Primary tracheal tumors are rare and trachea is an exceedingly rare site of extramedullary plasmacytoma (EMP). We report a case of solitary tracheal plasmacytoma causing symptoms of airway obstruction in a 59-year-old man. Flow/volume loop indicated the fixed central airway obstruction. Computerized tomography and bronchoscopy demonstrated a sessile tumor on posterior tracheal wall obstructing 80% of the lumen. Partial tracheal resection with T-T anastomosis was performed. Pathologic analysis of resected mass revealed EMP...
October 23, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29055877/surgical-treatment-of-locally-advanced-papillary-thyroid-carcinoma-after-response-to-lenvatinib-a-case-report
#12
Mitsuhiro Tsuboi, Hiromitsu Takizawa, Mariko Aoyama, Akira Tangoku
INTRODUCTION: Differentiated thyroid carcinomas (DTC) have good prognoses after complete resection. Nevertheless, when DTC is associated with an aerodigestive invasion, curative surgery is difficult to perform. However, there is no established neoadjuvant therapy for advanced DTC. PRESENTATION OF CASE: A 73-year-old man with thyroid papillary carcinoma was referred to our hospital. A computed tomography examination revealed a tumor in the upper right lobe of the thyroid, and multiple bilateral enlarged lymph nodes in the neck, involving the surrounding structures...
October 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28979140/predictive-factors-and-prognosis-for-recurrent-laryngeal-nerve-invasion-in-papillary-thyroid-carcinoma
#13
Wenjie Chen, Jianyong Lei, Jiaying You, Yali Lei, Zhihui Li, Rixiang Gong, Huairong Tang, Jingqiang Zhu
BACKGROUND: Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS: A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid Surgery Center of West China Hospital of Sichuan University were reviewed. Demographics and clinical factors, imaging examination (ultrasonography) characteristics, surgical details, postoperative pathological details, recurrence, and postoperative complications were recorded...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28971654/-surgical-treatment-of-locally-advanced-well-differentiated-thyroid-carcinoma
#14
Shorook Na'ara, Moran Amit, Salem Billan, Jacob Cohen, Ziv Gil
AIMS: We aimed to better define the most appropriate therapeutic protocol for this type of tumor. BACKGROUND: The incidence of well-differentiated thyroid carcinoma is rising and the mortality from the disease remains low for patients with early disease. Nevertheless, the survival of patients with advanced disease has not improved during the last four decades and a controversy still exists in the literature regarding the optimal treatment in patients with locally advanced (T4) differentiated thyroid carcinoma...
September 2017: Harefuah
https://www.readbyqxmd.com/read/28969727/manual-trans-tracheal-high-frequency-positive-pressure-ventilation-for-left-main-bronchus-and-carinal-mass-surgical-resection-in-a-child
#15
Mohammad Irfan Akhtar, Faisal Junejo, Hamid Iqil Naqvi, Mohammad Hamid
Inflammatory myofibroblastic tumor (IMT), also called pseudo-tumor, is a very rare condition and accounts for less than 1% of primary lung tumor. It is most common benign tumor of lung in children. This case is reported with the objective of highlighting the role of manual trans-tracheal high frequency positive pressure ventilation (HFPPV) in facilitating surgical resection with maintenance of adequate oxygenation and a little compromised ventilation. A9-year boy, weighing 21 kg, was diagnosed as a case of IMTof left main bronchus on biopsy and was successfully treated by surgical excision through left thoracotomy...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28957010/causes-of-normal-mortality-in-commercial-egg-laying-chickens
#16
Richard M Fulton
In a large population of animals, it is normal to have some die each day from causes not related to disease, which is often referred to as natural causes. In poultry production, this phenomenon is commonly referred to as daily mortality. In egg-producing chickens, many of the natural causes of death are associated with making an egg. The causes of normal mortality in commercial egg-laying chicken flocks have been described very little to date. A commercial chicken egg farm, housing approximately two million single-comb white leghorn chickens (Gallus gallus domesticus) in 16 egg-producing flocks, was visited on a monthly basis to monitor bird health, body conditioning, skeletal integrity, and causes of daily mortality in an attempt to provide early detection of health abnormalities...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28927948/survival-trends-in-patients-with-tracheal-carcinoma-from-1973-to-2011
#17
Surbhi Agrawal, Christopher Jackson, Karel-Bart Celie, Chetan Dodhia, Daphne Monie, Jose Monzon, Theodor Kaufman, Nicholas J Hellenthal
PURPOSE: The prognosis for primary tracheal cancer is dismal. We investigated whether there has been improvement in survival in tracheal cancer patients and how treatment modality affected overall and cancer-specific survival. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database, 1144 patients with tracheal cancer were identified between 1973 and 2011. Patients were stratified by age group, gender, race, tumor histology, and treatment modality...
August 26, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28927041/anastomosis-in-the-absence-of-a-suprahyoid-release-following-circumferential-sleeve-resection-is-feasible-in-differentiated-thyroid-carcinoma-patients-with-tracheal-invasion
#18
Wanjun Chen, Shujuan Zou, Liang Wang, Changhua Wu, Zhiqi Wang, Ke Li, Shuguang Zhang
Invasion of the trachea is observed in ~6% of patients with differentiated thyroid carcinoma (DTC), and surgery is accepted as the treatment of choice. However, surgical procedures can be challenging and are associated with various risks. The authors of the present study performed a retrospective study of patients with DTC and tumor invasion of the trachea. Outcomes from patients that received circumferential sleeve resection (CSR) of the trachea followed by anastomosis in the absence of suprahyoid release (n=21; CSR group) and patients that underwent tangential resections [n=103; tangential 'shave' resection (TSR) group) were analyzed...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28920047/the-effects-of-endotracheal-tube-and-i-gel%C3%A2-supraglottic-airway-device-on-respiratory-impedance-a-prospective-observational-study
#19
Shoko Nakano, Junko Nakahira, Yosuke Kuzukawa, Toshiyuki Sawai, Toshiaki Minami
BACKGROUND: The forced oscillation technique (FOT) is a non-invasive means of measuring respiratory resistance and reactance. We tested our hypothesis that endotracheal intubation would cause more substantial preoperative increases in FOT parameters than a supraglottic airway device (SGD). METHODS: Forty patients requiring general anesthesia and mechanical ventilation for transurethral bladder tumor resection underwent spirometry the day before surgery. Forced oscillation was measured using a MostGraph-01 device the day before surgery and immediately after removal of the airway adjunct...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28912876/effect-of-intercostal-nerve-block-combined-with-general-anesthesia-on-the-stress-response-in-patients-undergoing-minimally-invasive-mitral-valve-surgery
#20
Yanping Zhan, Guo Chen, Jian Huang, Benchao Hou, Weicheng Liu, Shibiao Chen
The aim of the present study was to investigate the effect of intercostal nerve block combined with general anesthesia on the stress response and postoperative recovery in patients undergoing minimally invasive mitral valve surgery (MIMVS). A total of 30 patients scheduled for MIMVS were randomly divided into two groups (n=15 each): Group A, which received intercostal nerve block combined with general anesthesia and group B, which received general anesthesia alone. Intercostal nerve block in group A was performed with 0...
October 2017: Experimental and Therapeutic Medicine
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