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https://www.readbyqxmd.com/read/28225857/malignant-melanoma-with-synchronous-thyroid-metastases-case-report-and-literature-review
#1
Maria Manuel Costa, Sandra Belo, João Capela-Costa, Jennifer Costa, Davide Carvalho
Thyroid metastases are rare in clinical practice. We describe the case of an 85-year-old woman who was referred to our department due to a multinodular goiter with compressive symptoms and subclinical hyperthyroidism. The patient was also undergoing evaluation for a polyp in her left nasal cavity, which was then diagnosed as a malignant melanoma of the nasal mucosa. A thoracoabdominal magnetic resonance imaging obtained for cancer staging revealed a > 50% tracheal obstruction caused by the goiter. The patient underwent simultaneous total thyroidectomy and melanoma excision...
February 16, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28192751/ameliorative-potential-of-linagliptin-and-or-calcipotriol-on-bleomycin-induced-lung-fibrosis-in-vivo-and-in-vitro-study
#2
Ahmed M Kabel, Maaly A Abd Elmaaboud, Aliaa Atef, Mohammed H Baali
Pulmonary fibrosis is a serious medical problem that may significantly compromise respiratory functions. The aim of this work was to study the effect of linagliptin and/or calcipotriol on bleomycin-induced pulmonary fibrosis and to explore the possible mechanisms underlying this effect. One hundred and twenty male C57BL/6 mice were divided into 6 equal groups as follows: control group; bleomycin group; bleomycin+carboxymethylcellulose group; bleomycin+linagliptin group; bleomycin+calcipotriol group and bleomycin+linagliptin+calcipotriol group...
February 4, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28149577/tracheal-and-bronchial-tumors
#3
REVIEW
Patricio Varela, Luca Pio, Elisa Brandigi, Irene Paraboschi, Nazhia Khen-Dunlop, Erik Hervieux, Cecile Muller, Girolamo Mattioli, Sabine Sarnacki, Michele Torre
Although primary tracheobronchial tumors are extremely rare in children, recurrent respiratory symptoms resistant to conventional therapy require further investigations to exclude possible malignant obstructive causes. As the matter of fact, early diagnosis may allow minimally invasive surgeries, improving the standard of living and the globally survival rate. The aim of this article is to provide an overview of diagnosis and management of tracheobronchial tumors in the early age, since only few reports are reported in the worldwide literature...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28133561/thoracoscopic-surgery-for-glomus-tumor-an-uncommon-mediastinal-neoplasm-and-iatrogenic-tracheal-rupture
#4
Zhongjie Fang, Dehua Ma, Baofu Chen, Huarong Luo
Mediastinal glomus tumors are rarely recognized, and only seven cases have been reported in the literature. Here, we describe a rare mediastinal glomus tumor and review the characteristics of this rare clinical case. The patient was a 50-year-old female who presented with coughing for 3 months. Her chest computed tomography scan demonstrated a localized tumor in the posterior superior mediastinum. Intraoperatively, we found a longitudinal rupture of the membranous trachea above the carina. We completely resected the tumor and repaired the tracheal rupture under a thoracoscopy using a pedicled muscle flap...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28133204/-salvage-surgery-after-crt-for-advanced-esophageal-cancer-resulting-in-a-pathological-complete-response-and-more-than-five-years-survival
#5
Sachiko Kaida, Satoshi Murata, Tsuyoshi Yamaguchi, Reiko Ohtake, Katsushi Takebayashi, Hiroshi Yamamoto, Tomoyuki Ueki, Toru Miyake, Hiroya Iida, Hiroya Akabori, Hiromichi Sonoda, Tsuyoshi Mori, Tomoharu Shimizu, Shigeyuki Naka, Masaji Tani
A 62-year-old woman visited our hospital because of dysphagia. She was diagnosed with upper-middle esophageal type 4 cancer, which was 9 cm in length, according to the results of endoscopy. Squamous cell carcinoma was demonstrated using endoscopic biopsy. A CT scan revealed that the tumor had directly invaded into the trachea(cT4). Chemoradiotherapy(CRT) (5-FU and CDDP with 50 Gy of radiation)was administered. Although CT after CRT resulted in shrinkage of the tumor and no further tracheal invasion, esophageal stenosis remained...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28109369/successful-treatment-of-an-aggressive-tracheal-malignancy-with-immunotherapy
#6
Asishana A Osho, Christopher J Azzoli, Sara Pai, Mari Mino-Kenudson, William C Faquin, Tiffany G Huynh, Michael Lanuti, Douglas J Mathisen, Ashok Muniappan
Immune checkpoint inhibitors are emerging as therapeutic options for oncology patients in whom conventional treatment regimens have failed. These immunotherapies counteract tumor-induced tolerance and have been shown to be effective in thoracic malignancies, including non-small cell lung cancer (NSCLC). This report highlights the successful use of nivolumab-an immunotherapeutic agent that binds to proteins involved in T-cell proliferation-for the management of recurrent tracheal squamous cell cancer after exhaustion of conventional surgical, chemotherapeutic, and radiation therapy options...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28088789/gprc5a-knockout-mouse-lung-epithelial-cells-predicts-ceruloplasmin-lipocalin-2-and-periostin-as-potential-biomarkers-at-early-stages-of-lung-tumorigenesis
#7
Beibei Sun, Wenzheng Guo, Song Hu, Feng Yao, Keke Yu, Jie Xing, Ronghua Wang, Hongyong Song, Yueling Liao, Tong Wang, Pengfei Jiang, Baohui Han, Jiong Deng
Lung cancer is the leading cause of cancer death. As most of lung cancer patients were diagnosed with the advanced stage, early detection is considered as the most effective strategy to reduce high mortality. Thus, it is desirable to identify specific biomarkers at early stages of lung tumorigenesis. GPRC5A is a lung tumor suppressor gene. GPRC5A deficiency is linked to lung cancer development. We hyposthesized that, dysregulated gene expression that results from Gprc5a deficiency may provide potential biomarkers at early stages of lung tumorigenesis...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28066620/tracheobronchial-tumors
#8
REVIEW
Ruza Stevic, Branislava Milenkovic
Tumors of trachea and bronchi are uncommon and can occur in the form of benign or low- and high-grade malignant tumors. Although tracheobronchial tumors (TBTs) represent only 0.6% of all pulmonary tumors, they are clinically significant. Delays in diagnosis of these tumors commonly occur because the signs and symptoms caused by these tumors are nonspecific and chest radiographs are often considered unremarkable. Therefore, novel radiological techniques and better access to flexible bronchoscopy enable detection of larger number of TBT...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28039009/percutaneous-ct-fluoroscopic-guided-radioisotope-seed-placement-for-the-management-of-adenoid-cystic-carcinoma-of-the-trachea
#9
Stephen Doggett, Shigeru Chino, Todd Lempert, Jay Federhart
PURPOSE: Tracheal and paratracheal malignancies present challenges in radiotherapeutic management due to their proximity to sensitive structures, central location, and because of the potential for catastrophic radiation induced fistula. The use of external beam radiation therapy and intraluminal brachytherapy has a limited number of reports in the literature. We have searched for a technique for treating tracheal and paratracheal malignancies allowing application of a high dose of radiation while minimizing dose to normal tissues...
December 27, 2016: Brachytherapy
https://www.readbyqxmd.com/read/28033203/outcomes-of-extracorporeal-life-support-during-surgery-for-the-critical-airway-stenosis
#10
Seon Hee Kim, Seunghwan Song, Yeong Dae Kim, Hoseok I, Jeong Su Cho, Hyo Yeong Ahn, Jonggeun Lee, Do Hyung Kim, Bong Soo Son
Anesthetic management of critical airway stenosis is often very challenging. Extracorporeal membrane oxygenation (ECMO) may provide adequate respiratory support when conventional approaches fail. We report our experience of ECMO support for critical airway surgery. Between April 2012 and March 2015, nine patients underwent ECMO-supported airway operation. The reason for surgery was tracheal stenosis in nine patients, and tracheomalacia, tracheal tumor, and external tracheal compression by mediastinal mass in one patient each...
January 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28024212/thymoma-in-middle-mediastinum-that-induced-tracheal-compression-case-report-and-literature-review
#11
Teiko Sakurai, Tetsuki Sakamoto, Tomoko Wakasa, Yoshio Ohta, Hiroyuki Shiono
BACKGROUND: A thymoma, an epithelial neoplasm of the thymus, mainly occurs in the anterior mediastinum, while few are seen in the middle mediastinum. CASE PRESENTATION: An 83-year-old male was referred for an incidental mass in the middle mediastinum. He had severe dementia and denied symptoms. Our follow-up computed tomography (CT) examinations had revealed the progress of tracheal compression along with tumor enlargement for 2 years. At 85 years old, we performed a thymomectomy via a median sternotomy to avoid complete trachea obstruction...
December 13, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28008898/-argon-laser-ablation-is-a-new-method-of-airways-recanalization-for-tumoral-stenosis
#12
A A Rusanov, N V Kazakov, A V Gerasin, M G Kovalev, A L Akopov
AIM: To develop the new method of laser recanalization of airways for tumoral stenosis. MATERIAL AND METHODS: It is proposed to conduct laser effect in the gas environment that does not support combustion (argon). Also the device for these AIM: is suggested. The method is called argon-laser ablation (ALA). A comparison of ALA and conventional high-energy laser exposure (LPD) was performed. RESULTS: ALA and LPD were used in 46 patients and 17 patients with non-small cell lung cancer...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27994928/a-solitary-fibrous-tumor-of-the-subglottic-larynx-case-report-and-literature-review
#13
Sung-Joon Park, Young Hen Lee, Ki Yeol Lee, Kyoung Ho Oh, Younghye Kim
BACKGROUND: Solitary fibrous tumors (SFT) arising from the larynx are extremely rare; most occur in the supraglottic larynx. CASE REPORT: Herein, we detail a new case of a subglottic SFT presenting as a well-encapsulated soft-tissue tumor with hoarseness. It showed isoattenuation, similar to the adjacent muscle on pre-contrast computed tomography (CT) images, and strong, heterogeneous enhancement following contrast material administration, which may reflect hypervascularity...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27991022/-minimal-invasive-esophageal-resection-with-anastomosis-on-the-neck-mckeown-our-experiences-after-20-cases
#14
Elemér Mohos, Attila Nagy, György Szabados, György Réti, Tamás Kovács, Zoltán Jánó, Csaba Berki, József Mohay, Lóránt Szabó, Krisztina Bene, Gábor Bognár, Myroslav Horzov, Petra Mohos, Gábor Sándor, Gábor Tornai, Péter Szenkovits, Tibor Nagy, Csaba Orbán, Vivien Herpai
OBJECTIVE: Esophageal resection is a traumatic intervention usually performed on patients with poor condition, resulting high mortality and morbidity. To improve the high incidence of complications, minimal invasive interventions were introduced. The results of the thoracoscopically and laparoscopically performed esophageal resection (McKeown) was investigated after 20 cases and the technical details of the surgical intervention are presented. PATIENTS AND METHOD: 20 thoracoscopic esophageal resection with laparoscopic gastric tube formation (sec...
December 2016: Magyar Sebészet
https://www.readbyqxmd.com/read/27858901/primary-mucoepidermoid-carcinoma-at-the-carina-of-trachea-presenting-with-wheezing-in-an-asthmatic-child-mimicking-an-attack-of-asthma-a-case-report
#15
Chien-Heng Lin, Yu-Hua Chao, Kang-Hsi Wu, Wei-Ching Lin
BACKGROUND: Asthma is a very common disease, but primary tracheal tumors are extremely rare in children. Wheezing is not pathognomonic, but is the typical presentation of asthma and could also be found in patients with tracheal tumors. CLINICAL FINDINGS: This report describes a 12-year-old boy with a previous history of frequent asthma attacks and experienced responses to antiasthma treatment. He was admitted to the hospital due to persistent wheezing and progressive dyspnea...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27846176/mediastinoscopy-assisted-transhiatal-esophagectomy-for-esophageal-cancer-a-single-institutional-cohort-study
#16
Tsutomu Nomura, Takeshi Matsutani, Nobutoshi Hagiwara, Itsuro Fujita, Yoshiharu Nakamura, Hiroshi Makino, Masao Miyashita, Eiji Uchida
We compared the therapeutic outcomes of mediastinoscopy-assisted transhiatal esophagectomy (MATHE) with transthoracic esophagectomy (TTE), and with video-assisted thoracoscopic esophagectomy (VATS-E) for the treatment of esophageal cancer. Twenty patients underwent MATHE in our institute from 2001 to 2005 were enrolled. We evaluated the therapeutic outcomes, including perioperative complications and long-term prognosis after surgery, and compared these with 15 patients who underwent TTE during the same time period and 15 who underwent VATS-E at a later date...
December 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27792106/giant-cell-tumor-of-cervical-spine-presenting-as-acute-asphyxia-successful-surgical-resection-after-down-staging-with-denosumab
#17
Rajendra Kumar, Jeanne M Meis, Behrang Amini, Kevin W McEnery, John E Madewell, Laurence D Rhines, Robert S Benjamin
STUDY DESIGN: Case report and literature review. OBJECTIVE: To describe treatment of a unique case of acute airway obstruction by a large C7 giant cell tumor (GCT) with pre-operative denosumab followed by surgical resection, and review the literature on this rare entity. SUMMARY OF BACKGROUND DATA: Standard treatment for GCTs includes surgical resection or curettage and packing. Large lesions in the spine may require pre-operative therapy with denosumab, a human monoclonal antibody to RANKL, to facilitate surgery...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27780931/marital-status-is-an-independent-prognostic-factor-for-tracheal-cancer-patients-an-analysis-of-the-seer-database
#18
Mu Li, Chen-Yang Dai, Yu-Ning Wang, Tao Chen, Long Wang, Ping Yang, Dong Xie, Rui Mao, Chang Chen
BACKGROUND: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. RESULTS: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27703512/expression-of-toll-like-receptor-4-in-lungs-of-immune-suppressed-rat-with-acinetobacter-baumannii-infection
#19
Yanmei Wang, Xiaohong Zhang, Xuanlin Feng, Xiaoshu Liu, Lei Deng, Zong-An Liang
Toll-like receptor 4 (TLR4) is involved in the regulation of host responses to Acinetobacter baumannii (A. baumannii). The aim of the present study was to examine the function of TLR4 in lung inflammation in immune-suppressed rats with A. baumannii infection. A total of 72 Sprague-Dawley male rats were randomly divided into the control, A. baumannii infection and immune-suppressed infection groups. The immune-suppressed infection group was treated with 100 mg/kg hydrocortisone by subcutaneous injection every other day for 2 weeks prior to A...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27686964/the-antifibrotic-effects-of-alveolar-macrophages-5-ht2c-receptors-blockade-on-bleomycin-induced-pulmonary-fibrosis-in-rats
#20
Samah M Elaidy, Soha S Essawy
BACKGROUND: The most widespread chronic fibrosing lung disease is idiopathic pulmonary fibrosis. Lung serotonin (5-HT) content is increased during pulmonary fibrosis with the implication of 5-HT2 receptors in the pathogenesis. Serotonin plays important roles in alveolar macrophages function through 5-HT2C receptors activation. Numerous studies described the important role of 5-HT2A/B receptor blockers in suppressing different types of fibrosis as idiopathic pulmonary fibrosis. The current study pointed to examine the antifibrotic effects of RS-102221 and/or terguride through in vivo model of pulmonary fibrosis...
December 2016: Pharmacological Reports: PR
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