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https://www.readbyqxmd.com/read/29935368/long-term-survival-after-partial-hepatectomy-for-sub-stage-patients-with-intermediate-stage-hepatocellular-carcinoma
#1
Wen-Xin Wei, Zhi-Shi Yang, Li-Hua Lu, Jun Li, Zheng-Qing Lei, Kui Wang, Yong Xia, Zhen-Lin Yan, Feng Shen
BACKGROUND: The current study aimed to examine the long-term survival after partial hepatectomy for patients with BCLC intermediate stage hepatocellular carcinoma (HCC) stratified by the Bolondi's sub-staging model. MATERIALS AND METHODS: This cohort consisted of 360 patients with BCLC intermediate stage HCC who underwent partial hepatectomy between January 2008 and February 2010. Patients were stratified into 3 subgroups (B1-B3) based on the Bolondi's sub-staging model...
June 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29935365/laparoscopic-hepatectomy-versus-open-hepatectomy-for-hepatocellular-carcinoma-in-157-patients-a-case-controlled-study-with-propensity-score-matching-at-two-chinese-centres
#2
Zhi-Cheng Deng, Wen-Zhu Jiang, Xiao-Dong Tang, Shuang-Hai Liu, Lei Qin, Hai-Xin Qian
BACKGROUND: The aim of this study was to investigate the long-term outcomes and perioperative outcomes of laparoscopic hepatectomy (LH) versus open hepatectomy (OH) for hepatocellular carcinoma (HCC) between well-matched patient groups. METHODS: We retrospectively reviewed data from 1535 hepatocellular carcinoma patients who underwent liver resection between January 2002 and December 2016 at two Chinese centres. Propensity score matching of patients in a ratio of 1:1 was conducted and 157 patients were matched...
June 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29933267/perioperative-management-in-hepatic-resections-comparative-effectiveness-of-neuraxial-anesthesia-and-disparity-of-care-patterns
#3
Jeron Zerillo, Parul Agarwal, Jashvant Poeran, Nicole Zubizarreta, George Poultsides, Myron Schwartz, Stavros Memtsoudis, Madhu Mazumdar, Samuel DeMaria
BACKGROUND: Complication rates after hepatic resection can be affected by management decisions of the hospital care team and/or disparities in care. This is true in many other surgical populations, but little study has been done regarding patients undergoing hepatectomy. METHODS: Data from the claims-based national Premier Perspective database were used for 2006 to 2014. The analytical sample consisted of adults undergoing partial hepatectomy and total hepatic lobectomy with anesthesia care consisting of general anesthesia (GA) only or neuraxial and GA (n = 9442)...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29929759/incidence-and-trends-of-cardiac-complications-in-major-abdominal-surgery
#4
Yas Sanaiha, Yen-Yi Juo, Esteban Aguayo, Young-Ji Seo, Vishal Dobaria, Boback Ziaeian, Peyman Benharash
INTRODUCTION: Cardiovascular complications are the leading cause of death after noncardiac surgery. Major abdominal operations represent the largest category of procedures considered to have an increased risk of cardiovascular complications. The current aim was to examine trends in the incidence of mortality, perioperative myocardial infarction, and cardiac arrest to determine the presence of potential volume-outcome relationships. METHODS: We performed a retrospective analysis of the Nationwide Inpatient Sample for patients undergoing elective, open abdominal esophagectomy, gastrectomy, pancreatectomy, nephrectomy, hepatectomy, splenectomy, and colectomy (major abdominal surgery) during 2008-2014...
June 18, 2018: Surgery
https://www.readbyqxmd.com/read/29927634/detection-of-recurrent-hepatocellular-carcinoma-after-surgical-resection-non-contrast-liver-mr-imaging-with-diffusion-weighted-imaging-versus-gadoxetic-acid-enhanced-mr-imaging
#5
Ji Hye Min, Young Kon Kim, Seo-Youn Choi, Tae Wook Kang, Woo Kyoung Jeong, Kyunga Kim, Ho-Jeong Won
OBJECTIVES: To compare the diagnostic performance of non-contrast liver magnetic resonance (MR) imaging to whole MR imaging using gadoxetic acid for detection of recurrent hepatocellular carcinoma (HCC) after hepatectomy. METHODS: This retrospective study analyzed 483 patients who underwent surveillance with liver MR imaging after hepatectomy for HCC (median time interval, 7.7 months). Non-contrast MR imaging set (T1-and T2 -weighted and diffusion-weighted images [DWI]) and whole MR imaging set (gadoxetic acid-enhanced and non-contrast MR imaging) were analyzed independently by two observers...
June 21, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29925683/monitoring-liver-damage-using-hepatocyte-specific-methylation-markers-in-cell-free-circulating-dna
#6
Roni Lehmann-Werman, Judith Magenheim, Joshua Moss, Daniel Neiman, Ofri Abraham, Sheina Piyanzin, Hai Zemmour, Ilana Fox, Talya Dor, Markus Grompe, Giora Landesberg, Bao-Li Loza, Abraham Shaked, Kim Olthoff, Benjamin Glaser, Ruth Shemer, Yuval Dor
Liver damage is typically inferred from serum measurements of cytoplasmic liver enzymes. DNA molecules released from dying hepatocytes are an alternative biomarker, unexplored so far, potentially allowing for quantitative assessment of liver cell death. Here we describe a method for detecting acute hepatocyte death, based on quantification of circulating, cell-free DNA (cfDNA) fragments carrying hepatocyte-specific methylation patterns. We identified 3 genomic loci that are unmethylated specifically in hepatocytes, and used bisulfite conversion, PCR, and massively parallel sequencing to quantify the concentration of hepatocyte-derived DNA in mixed samples...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29924662/current-state-of-enhanced-recovery-after-surgery-in-hepatopancreatobiliary-surgery
#7
William C Buhrman, William B Lyman, Russell C Kirks, Michael Passeri, Dionisios Vrochides
For over two decades, enhanced recovery pathways have been implemented in many surgical disciplines, most notably in colorectal surgery. Since 2001, the Enhanced Recovery After Surgery (ERAS® ) Study Group has developed a main protocol comprising 24 evidence-based core items. While these core items unite similar preoperative, intraoperative, and postoperative principles across surgical subspecialties, variations and modifications exist to these core items based on unique considerations for each surgical subspecialty...
June 20, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29924209/capsiate-treatment-in-liver-surgeries-may-compromise-its-recovery
#8
Pedro Paulo Barros, Gisele Mara Silva Gonçalves, Gustavo Henrique da Silva, Maria Clara Villaça Dias Bastos, Loren Nogaroto Ramos, Marilia Marinello Fernandes
PURPOSE: To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats. METHODS: The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH...
May 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29924030/acute-portal-vein-thrombosis-after-hepatectomy-in-a-patient-with-hepatolithiasis-a-case-report-and-review-of-the-literature
#9
Zun-Yi Zhang, Ke-Shuai Dong, Er-Lei Zhang, Zhi-Yong Huang, Xiao-Ping Chen, Han-Hua Dong
RATIONALE: Portal vein thrombosis is defined as any thrombosis that develops in the portal vein system. It is considered a very rare and extremely lethal complication of hepatopancreatobiliary surgery. PATIENT CONCERNS: Acute portal vein thrombosis after hepatectomy in patients with hepatolithiasisis very rare. Acute portal vein thrombosis is considered as a dangerous complication after hepatectomy. It is easy to ignore the symptom of acute portal vein thrombosis...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29921239/which-approach-is-preferred-in-left-hepatocellular-carcinoma-laparoscopic-versus-open-hepatectomy-using-propensity-score-matching
#10
Jong Man Kim, Choon Hyuck David Kwon, Heejin Yoo, Kyeung-Sik Kim, Jisoo Lee, Kyunga Kim, Gyu-Seong Choi, Jae-Won Joh
BACKGROUND: Laparoscopic liver resection has been reported as a safe and effective approach for the management of hepatocellular carcinoma (HCC). However, its perioperative and oncological outcomes have not been evaluated in left hepatectomy patients. The aim of the present study is to compare the outcomes of left hepatectomy through laparoscopic and open approaches in left HCC. METHODS: From December 2012 to October 2016, laparoscopic left hepatectomy (LLH) was performed in 40 patients and open left hepatectomy (OLH) was performed in 80 patients...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29916882/paradigm-shift-in-the-management-of-irresectable-colorectal-liver-metastases-living-donor-auxiliary-partial-orthotopic-liver-transplantation-in-combination-with-two-stage-hepatectomy-ld-rapid
#11
Alfred Königsrainer, Silke Templin, Ivan Capobianco, Ingmar Königsrainer, Michael Bitzer, Lars Zender, Bence Sipos, Lothar Kanz, Silvia Wagner, Silvio Nadalin
OBJECTIVE: to report the first case of resection and partial liver segment 2-3 transplantation with delayed total hepatectomy (RAPID) from living donor in a patient affected of irresectable colorectal liver metastases (i-CRLM) BACKGROUND:: A renaissance of liver transplantation (LT) for i-CRLM has been recently observed. The Norwegian SECA trial demonstrated a 5-year overall survival rate of approximately 60%, notwithstanding early tumor recurrence. The RAPID technique was recently introduced as alternative to whole deceased donor LT, but it is limited by poor availability of splittable organs and many organisational aspects...
June 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29916108/anatomy-of-the-right-anterior-sector-of-the-liver-and-its-clinical-implications-in-surgery
#12
Jean-Baptiste Cazauran, Lucas Pâris, Pascal Rousset, Frédéric Mercier, Vahan Kepenekian, Anthony Viste, Guillaume Passot
BACKGROUND: Surgery remains the gold standard both for delimited hepatocellular carcinoma by selective anatomic liver segentectomy and for colorectal liver metastases by parenchymal sparing liver resection. Right anterior sector (RAS) (segments V-VIII; Couinaud) is the largest and most difficult sector to operate on. A better knowledge of its segmentation could prevent postoperative remnant liver ischemia and its impacts on patient's survival. METHODS: A literature search was conducted in PubMed for papers on anatomy and surgery of the right anterior sector...
June 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29916104/anatomical-boundary-between-the-caudate-lobe-of-the-liver-and-adjacent-segments-based-on-three-dimensional-analysis-for-precise-resections
#13
Harufumi Maki, Yoshihiro Sakamoto, Yoshikuni Kawaguchi, Nobuhisa Akamatsu, Junichi Kaneko, Junichi Arita, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Right hemihepatectomy or systematic resection of segment 7 or 8 involves partial resection of the paracaval portion of the caudate lobe. However, the boundary between the caudate lobe and segment 7 or 8 remains unclear. We examined the anatomical territory of the caudate lobe with special reference to the boundary between the paracaval portion and segment 7 or 8 for precise anatomical hepatectomies. METHODS: We enrolled 63 consecutive healthy donor candidates for living-donor liver transplantation from 2012 to 2014 in this study...
June 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29916092/multiple-hepatic-sclerosing-hemangiomas-a-case-report-and-review-of-the-literature
#14
Kyohei Yugawa, Tomoharu Yoshizumi, Noboru Harada, Takashi Motomura, Norifumi Harimoto, Shinji Itoh, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Hepatic sclerosing hemangioma, a very rare benign tumor, is characterized by fibrosis and hyalinization occurring in association with degeneration of a hepatic cavernous hemangioma. Such atypical hemangiomas can be diagnosed incorrectly as primary or metastatic malignancies based on imaging characteristics. We present herein a rare case of giant and multiple hepatic sclerosing hemangiomas that are difficult to differentiate from hepatic malignancies and review the relevant literature...
June 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29915920/successful-treatment-of-isolated-bile-leakage-after-hepatectomy-combination-therapy-with-percutaneous-transhepatic-portal-embolization-and-bile-duct-ablation-with-ethanol-a-case-report
#15
Norio Kubo, Norifumi Harimoto, Kei Shibuya, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Kenichiro Araki, Masaya Miyazaki, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND: Bile leakage after hepatectomy still causes relatively serious problems, and some types of bile leakage are intractable. CASE PRESENTATION: We report a case of postoperative isolated bile duct leakage managed successfully by combination therapy of percutaneous transhepatic portal vein embolization (PTPE) and bile duct ablation with ethanol. A 61-year-old man diagnosed with hepatocellular carcinoma underwent partial hepatectomy. On postoperative day 1, bile leakage was detected at the drainage tube...
June 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29915481/intermittent-pringle-versus-continuous-half-pringle-maneuver-for-laparoscopic-liver-resections-of-tumors-in-segment-7
#16
Yu Zhang, Xiangyu Lu, Jian Xu, Hongji Yang, Xiaofan Deng, Kai Chen, Yunfei Chen
Segment 7 is considered an unfavorable portion for laparoscopic hepatectomy because of technical difficulties in exposure and controlling bleeding. We compared intermittent Pringle with continuous half-Pringle maneuver in laparoscopic liver resections of tumors in segment 7. A retrospective analysis was conducted in a total of 36 consecutive patients with tumors in segment 7 undergoing laparoscopic liver resections between July 2011 and February 2016 (16 in the Pringle group versus 20 in the half-Pringle group)...
April 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29915286/microrna-378-is-involved-in-hedgehog-driven-epithelial-to-mesenchymal-transition-in-hepatocytes-of-regenerating-liver
#17
Jieun Kim, Jeongeun Hyun, Sihyung Wang, Chanbin Lee, Youngmi Jung
Healthy livers have a remarkable regenerative capacity for reconstructing functional hepatic parenchyma after 70% partial hepatectomy (PH). Hepatocytes, usually quiescent in normal healthy livers, proliferate to compensate for hepatic loss after PH. However, the mechanism of hepatocyte involvement in liver regeneration remains unclear. Hedgehog (Hh) pathway plays an important role in tissue reconstitution by regulating epithelial-to-mesenchymal transition (EMT) in liver disease. MicroRNA (miRNA) is involved in cell proliferation and differentiation during embryonic development and carcinogenesis...
June 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29914487/blunt-liver-trauma-a-descriptive-analysis-from-a-level-i-trauma-center
#18
Ibrahim Afifi, Sheraz Abayazeed, Ayman El-Menyar, Husham Abdelrahman, Ruben Peralta, Hassan Al-Thani
BACKGROUND: We aimed to review liver injury experience in a level 1 trauma center; namely clinical presentation, grading, management approach and clinical outcomes. METHODS: It is a retrospective analysis to include all blunt liver injury patients who were admitted at the Level 1 trauma center over a 3-year period. Data were compared and analyzed based on the liver injury grades and management approaches. RESULTS: Blunt liver injury accounted for 38% of the total blunt abdominal trauma cases with a mean age of 31 ± 13 years...
June 19, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29912198/partial-lobular-hepatectomy-a-surgical-model-for-morphologic-liver-regeneration
#19
Jonathan M Tsai, Irving L Weissman, Yuval Rinkevich
Morphological organ regeneration following acute tissue loss is common among lower vertebrates, but is rarely observed in mammalian postnatal life. Adult liver regeneration after 70% partial hepatectomy results in hepatocyte hypertrophy with some replication in remaining lobes with restoration of metabolic activity, but with permanent loss of the injured lobe's morphology and architecture. Here, we detail a new surgical method in the neonate that leaves a physiologic environment conducive to regeneration. This model involves amputation of the left lobe apex and a subsequent conservative management regimen, and lacks the necessity for ligation of major liver vessels or chemical injury, leaving a physiologic environment where regeneration may occur...
May 31, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29905011/low-expression-of-ww-domain-containing-oxidoreductase-associates-with-hepatocellular-carcinoma-aggressiveness-and-recurrence-after-curative-resection
#20
Chenhao Zhou, Wanyong Chen, Jialei Sun, Manar Atyah, Yirui Yin, Wentao Zhang, Lei Guo, Qinghai Ye, Qiongzhu Dong, Yi Shi, Ning Ren
WW domain-containing oxidoreductase (WWOX), which has a protein-interaction domain and is regarded to be a tumor suppressor, has been known to play an important role in anti-angiogenesis and cancer progression. This study aimed to investigate prognostic values of WWOX expression in hepatocellular carcinoma (HCC) patients after hepatectomy. Additionally, we intended to formulate a valuable prognostic nomogram for HCCs. 182 HCC patients who underwent hepatectomy from January 2009 to January 2010 were enrolled in our study...
June 14, 2018: Cancer Medicine
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