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Hepatectomy

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https://www.readbyqxmd.com/read/29456045/hepatectomy-for-octogenarians-with-colorectal-liver-metastasis-in-the-era-of-enhanced-recovery
#1
Andrea Tufo, Declan F J Dunne, Nichola Manu, Heman Joshi, Carmen Lacasia, Louise Jones, Hassan Z Malik, Graeme J Poston, Stephen W Fenwick
BACKGROUND: Concern exists regarding the use of hepatectomy to treat colorectal liver metastasis (CRLM) in octogenarians due to prior studies suggesting elevated morbidity and mortality. Cardiopulmonary exercise testing (CPET) within pre-operative assessment and enhanced recovery after surgery (ERAS) have both been shown to be associated with low morbidity and mortality in patients undergoing hepatectomy. This study sought to compare the outcomes of octogenarians with patients aged 70-79 undergoing hepatectomy for CRLM, within a center utilizing both CPET and ERAS...
February 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29455543/effect-of-leucine-on-nf-%C3%AE%C2%BAb-pathway-in-liver-regeneration-after-partial-hepatectomy-in-rats-as-determined-by-miniarray-analysis
#2
E Ceyhan, M Canbek, M Uyanoglu, A Ozen, B Durmus Ozen, B Berber, A Ozmen Yaylaci, L Resulzade
BACKGROUND: Although some amino acids are recognized to have favorable effects on the liver regeneration after partial hepatectomy (PH), molecular mechanisms underlying these effects are barely known. OBJECTIVE: Our study was aimed to investigate the effects of valine, glutamine, and leucine amino acids on PH-induced NF-κB signal pathway. The research team studied Leucine in a rat model in vivo. The study took place in the medical and surgical experimental research center at the Eskisehir Osmangazi University in Eskisehir, Turkey...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455421/impact-of-baseline-characteristics-on-outcomes-of-advanced-hcc-patients-treated-with-sorafenib-a-secondary-analysis-of-a-phase-iii-study
#3
Omar Abdel-Rahman
BACKGROUND: The current study aims to investigate the impact of baseline characteristics on the outcomes of sorafenib-treated advanced Hepatocellular carcinoma (HCC) patients in the setting of a clinical trial. METHODS: This is a secondary analysis of the comparator arm (sorafenib arm) of the NCT00699374 study which is a phase III multicenter study conducted between 2008 and 2010. The univariate probability of overall and progression-free survival was assessed among different patient subsets through Kaplan-Meier analysis and log-rank testing...
February 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29454573/revisiting-donor-risk-over-two-decades-of-single-center-experience-more-attention-on-the-impact-of-overweight
#4
Cheng-Maw Ho, Yu-Min Huang, Rey-Heng Hu, Yao-Ming Wu, Ming-Chih Ho, Po-Huang Lee
OBJECTIVE: Morbidity rates after living donor hepatectomy vary greatly among centers. Donor morbidity in a tertiary center over the past two decades was revisited. METHODS: Clinical data and grading of complications were reviewed by a nontransplant surgeon based on Clavien 5 tier grading. Risk factors were analyzed. RESULTS: In total, 473 consecutive living liver donors from 1997 to 2016 were included for analysis; 305 were right liver donors and 168 left liver donors, and the corresponding morbidity rates were 27...
February 14, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29454570/fibrosis-score-impacts-survival-following-resection-for-hepatocellular-carcinoma-hcc-a-surveillance-end-results-and-epidemiology-seer-database-analysis
#5
Sivesh K Kamarajah
BACKGROUND/OBJECTIVES: Surgical extirpation for hepatocellular carcinoma (HCC) with background fibrosis remains a challenge. This study evaluated impact of fibrosis score on long term outcomes of patients undergoing surgical resection for HCC. METHODS: Using the Surveillance, Epidemiology and End Results (SEER) database (2004-2013), complete data on 1433 patients undergoing surgical resection for non-metastatic HCC were identified. Overall survival (OS) was estimated using the Kaplan-Meier method...
February 14, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29454099/two-stage-hepatectomy-vs-one-stage-major-hepatectomy-with-contralateral-resection-or-ablation-for-advanced-bilobar-colorectal-liver-metastases
#6
Takashi Mizuno, Jordan M Cloyd, Kiyohiko Omichi, Yun Shin Chun, Claudius Conrad, Ching-Wei D Tzeng, Steven H Wei, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: Both two-stage hepatectomy (TSH) and one-stage hepatectomy (OSH) represent feasible strategies for resection of advanced bilobar colorectal liver metastases (CLM). However, the influence of the surgical approach on postoperative outcomes and overall survival (OS) is unknown. To define the optimal surgical approach for advanced bilobar CLM requiring right hemihepatectomy, we compared short-term and long-term outcomes following TSH and OSH with contralateral resection or radiofrequency ablation (RFA)...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29454098/quantitative-imaging-features-and-postoperative-hepatic-insufficiency-a-multi-institutional-expanded-cohort
#7
Linda M Pak, Jayasree Chakraborty, Mithat Gonen, William C Chapman, Richard Kg Do, Bas Groot Koerkamp, Kees Verhoef, Ser Yee Lee, Marco Massani, Eric P van der Stok, Amber L Simpson
BACKGROUND: Post-hepatectomy liver insufficiency (PHLI) is a significant cause of morbidity and mortality after liver resection. Quantitative imaging analysis using CT scans measures variations in pixel intensity related to perfusion. A preliminary study demonstrated a correlation between quantitative imaging features of the future liver remnant (FLR) parenchyma from preoperative CT scans and PHLI. The objective of the present study was to explore the potential application of quantitative imaging analysis in PHLI in an expanded, multi-institutional cohort...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29453737/two-stage-hepatectomy-aiming-for-the-development-of-intrahepatic-venous-collaterals-for-multiple-colorectal-liver-metastases
#8
Harufumi Maki, Shouichi Satou, Kentaro Nakajima, Atsuki Nagao, Kazuteru Watanabe, Hitoshi Satodate, Satoshi Nara, Kaoru Furushima, Yasushi Harihara
BACKGROUND: Aggressive hepatectomy with venous resection has a higher risk of postoperative liver failure (POLF) than hepatectomy without venous reconstruction; however, venous reconstruction is technically demanding. We performed a novel two-stage hepatectomy (TSH) without venous reconstruction in a patient with bilobar multiple colorectal liver metastases located near the caval confluence, waiting for the development of intrahepatic venous collaterals between procedures. CASE PRESENTATION: A 60-year-old man was referred to our hospital with sigmoid colon cancer accompanied by intraabdominal abscess and two synchronous liver metastases...
February 16, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29450868/hepatocholangiocarcinoma-intrahepatic-cholangiocarcinoma-are-they-contraindication-or-indication-for-liver-transplantation-a-propensity-score-matched-analysis
#9
Ka Wing Ma, Kenneth Siu Ho Chok, Wong Hoi She, Tan To Cheung, Albert Chi Yan Chan, Wing Chiu Dai, James Yan Yue Fung, Chung Mau Lo
BACKGROUND: Uncommon primary hepatic malignancies such as intrahepatic cholangiocarcinoma (ICC) and hepatocholangiocarcinoma (HCC-CC) were generally considered contraindications for liver transplantation(LT), and studies comparing the efficacy of LT and resection (LR) for ICC/HCC-CC were scarce. OBJECTIVE: To compare the survival outcomes of ICC/HCC-CC patients treated by LT and LR in a propensity score-matched population. METHOD: This is a retrospective study from 1995 to 2015...
February 15, 2018: Hepatology International
https://www.readbyqxmd.com/read/29450751/left-lobe-mobilization-strategy-of-right-sided-major-hepatectomy-for-treatment-of-a-tumor-causing-severe-inferior-vena-cava-compression-a-novel-strategy-using-the-modified-liver-hanging-maneuver
#10
Kenichiro Araki, Norio Kubo, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND: Massive bleeding during major hepatectomy is associated with greater mortality and morbidity.1 Our previous study shows that inferior vena cava (IVC) compression by tumor and an anterior approach without the liver-hanging maneuver (LHM) are risk factors for massive bleeding.2 The LHM is useful for controlling bleeding in deeper parenchymal transection planes.3 However, severe compression of the IVC by tumor makes it difficult to insert a hanging tape.4 The study shows a novel modified LHM strategy for severe IVC compression to minimize intraoperative bleeding...
February 14, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29448301/histological-expression-of-methionine-adenosyl-transferase-mat-2a-as-a-post-surgical-prognostic-surrogate-in-patients-with-hepatocellular-carcinoma
#11
Jihyun An, Seong Kyun Na, Ju Hyun Shim, Yang Soon Park, Mi Jung Jun, Joo Ho Lee, Gi-Won Song, Hac Chu Lee, Eunsil Yu
BACKGROUND AND OBJECTIVES: Deregulation of methionine adenosyltransferase (MAT) is involved in hepatocarcinogenesis. This study aimed to investigate the prognostic implications of the level of histological MAT1A and MAT2A in patients with resected hepatocellular carcinoma (HCC). METHODS: A total of 210 patients with HCC who underwent curative resection between 2004 and 2011 were included. The levels of MAT proteins were immunohistochemically measured. RESULTS: MAT1A and MAT2A were over-expressed in 134 (63...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29444146/prediction-of-small-for-size-syndrome-after-extended-hepatectomy-tissue-characterization-by-relaxometry-diffusion-weighted-magnetic-resonance-imaging-and-magnetization-transfer
#12
Christian Eberhardt, Moritz C Wurnig, Andrea Wirsching, Cristina Rossi, Idana Feldmane, Mickael Lesurtel, Andreas Boss
This study aimed to monitor the course of liver regeneration by multiparametric magnetic-resonance imaging (MRI) after partial liver resection characterizing Small-for-Size Syndrome (SFSS), which frequently leads to fatal post-hepatectomy liver failure (PLF). Twenty-two C57BL/6 mice underwent either conventional 70% partial hepatectomy (cPH), extended 86% partial hepatectomy (ePH) or SHAM operation. Subsequent MRI scans on days 0, 1, 2, 3, 5 and 7 in a 4.7T MR Scanner quantified longitudinal and transverse relaxation times, apparent diffusion coefficient (ADC) and the magnetization-transfer ratio (MTR) of the regenerating liver parenchyma...
2018: PloS One
https://www.readbyqxmd.com/read/29439847/the-outcomes-of-central-hepatectomy-versus-extended-hepatectomy-a-systematic-review-and-meta-analysis
#13
REVIEW
Jenny Chan, Marcos Perini, Michael Fink, Mehrdad Nikfarjam
BACKGROUND: Central hepatectomy (CH) is a relatively uncommon liver resection technique. It is generally perceived as a more complex operation than extended hepatectomies (EH), with potentially higher associated morbidity. The outcomes of CH compared with EH is not well defined and there is a need to reassess. METHODS: A systematic literature search was conducted in PubMed, MEDLINE, EMBASE and Web of Science according to PRISMA guidelines for studies on the treatment of liver tumours with CH published from 1972 until February 2017...
February 10, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29439275/is-enhanced-one-stage-hepatectomy-a-safe-and-feasible-alternative-to-the-two-stage-hepatectomy-in-the-setting-of-multiple-bilobar-colorectal-liver-metastases-a-comparative-analysis-between-two-pioneering-centers
#14
Guido Torzilli, Luca Viganò, Matteo Cimino, Katsunori Imai, Eric Vibert, Matteo Donadon, Doaa Mansour, Denis Castaing, Ren Adam
BACKGROUND: Two-stage hepatectomy (TSH) is the present standard for multiple bilobar colorectal metastases (CLM). As alternative, ultrasound-guided one-stage hepatectomy (E-OSH) has been proposed even for deep-located nodules to compare TSH and E-OSH. METHODS: All consecutive TSH at the Paul Brousse Hospital and E-OSH at the Humanitas Research Hospital were considered. The inclusion criteria were ≥6 CLM, ≥3 CLM in the left liver, and ≥1 lesion with vascular contact...
February 13, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29436243/the-impact-of-using-three-dimensional-printed-liver-models-for-patient-education
#15
Tianyou Yang, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Jiahao Li, Yan Zou
Objective To investigate the impact of using a three-dimensional (3D) printed liver model for patient education. Methods Children with hepatic tumours who were scheduled for hepatectomy were enrolled, and patient-specific 3D liver models were printed with photosensitive resin, based on computed tomography (CT) images. Before surgery, their parents received information regarding liver anatomy, physiology, tumour characteristics, planned surgery, and surgical risks using these CT images. Then, parents completed questionnaires regarding this information...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29435902/pediatric-living-donor-liver-transplantation-using-a-monosegment-procured-by-pure-3d-laparoscopic-left-lateral-sectionectomy-and-in-situ-reduction
#16
Suk Kyun Hong, Kyung-Suk Suh, Hyo-Sin Kim, Kyung Chul Yoon, Sung-Woo Ahn, Hyeyoung Kim, Nam-Joon Yi, Kwang-Woong Lee
BACKGROUND: Improvements in laparoscopic imaging systems and instruments have increased the performance of pure laparoscopic living donor hepatectomy. This operation is no longer limited to left lateral sectionectomy but is used for left hepatectomy and right hepatectomy.1-5 This report describes a donor who underwent pure laparoscopic left lateral sectionectomy and in situ reduction using 3D laparoscopy and indocyanine green (ICG) near-infrared fluorescence cholangiography to obtain a monosegment...
February 12, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29434832/effects-of-liver-cirrhosis-on-portal-vein-embolization-prior-to-right-hepatectomy-in-patients-with-primary-liver-cancer
#17
Jun-Hui Sun, Yue-Lin Zhang, Chun-Hui Nie, Ju Li, Tan-Yang Zhou, Guan-Hui Zhou, Tong-Yin Zhu, Li-Ming Chen, Wei-Lin Wang, Shu-Sen Zheng
Preoperative portal vein embolization (PVE) induces compensatory hyperplasia of the future liver remnants (FLR), thus increasing resectability in the non-cirrhotic patients with primary liver cancer (PLC). However, it is unclear if it is similar in patients with liver cirrhosis. Therefore, the present study investigated the PVE value prior to liver resection in patients with PLC, and the liver cirrhotic effects on the compensatory hypertrophy of FLRs following PVE. In the present study, 21 patients with PLC who successfully underwent hepatic resection subsequent to PVE, were retrospectively examined...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432257/progression-of-living-liver-donation-worldwide
#18
Trevor L Nydam, Mettu Srinivas Reddy, Elizabeth A Pomfret, Mohamed Rela
PURPOSE OF REVIEW: Living donor liver transplantation (LDLT) has developed into a well tolerated and viable option when deceased donor transplantation is not available. Transplant and advanced hepatobiliary surgeons from around the world have performed living donor hepatectomies consistently for decades with acceptable donor outcomes. However, optimizing the preoperative workup, donor selection, operative technique, and perioperative care will improve these outcomes. This manuscript reviews recent worldwide literature for the living liver donor...
February 9, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29428419/resolution-of-giant-biliary-collection-by-spontaneous-colon-fistulization
#19
M Loreto-Brand, A Fernández-Pérez, R Varela-Ponte, E Varo-Pérez
The treatment of bile collections is divided into: expectant attitude with radiological monitoring of the size and characteristics of the collection, percutaneous drainage guided by imaging tests (US/CT), endoscopic drainage depending on location and accessibility and surgical treatment. The clinical case of a man undergoing a scheduled hepatectomy was observerd, who presented a large asymptomatic subcapsular collection suggestive of bilioma, with progressive increase in size, spontaneously presenting a decrease until its resolution by fistulization to the hepatic angle of the colon confirmed by Radiological findings...
February 7, 2018: Radiología
https://www.readbyqxmd.com/read/29428032/carbohydrate-antigen-19-9-increases-the-predictive-efficiency-of-%C3%AE-fetoprotein-for-prognosis-of-resected-hepatocellular-carcinoma
#20
Li Zhou, Jing-An Rui, Shao-Bin Wang, Shu-Guang Chen, Qiang Qu
Serum α-fetoprotein (AFP) is a classical biomarker for both diagnosis and prognosis of hepatocellular carcinoma (HCC). However, its predictive efficiency for prognosis remains unsatisfactory. This study explores whether integrating AFP and carbohydrate antigen (CA) 19-9/carcinoembryonic antigen (CEA) increase its prognostic efficiency in HCC. A total of 67 HCC patients with complete record of AFP, CA19-9, and CEA, who underwent radical hepatectomy, were included. The sole and combined evaluations for prognostic significance of the three markers were performed...
January 1, 2018: American Surgeon
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