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https://www.readbyqxmd.com/read/29232242/prediction-of-posthepatectomy-liver-failure-proposed-by-the-international-study-group-of-liver-surgery-residual-liver-function-estimation-with-99mtc-galactosyl-human-serum-albumin-scintigraphy
#1
Yoichi Mizutani, Toshinori Hirai, Shigeki Nagamachi, Atsushi Nanashima, Koichi Yano, Kazuhiro Kondo, Masahide Hiyoshi, Naoya Imamura, Tamasa Terada
PURPOSE: The International Study Group of Liver Surgery (ISGLS) proposed a definition and grading system for posthepatectomy liver failure (PHLF). We evaluated the usefulness of residual liver function estimation using Tc-galactosyl human serum albumin (Tc-GSA) for the prediction of PHLF. METHODS: Patients with liver tumors (n = 136) and scheduled for hepatectomy underwent Tc-GSA scintigraphy. Based on their imaging data, the maximal GSA removal rate (GSA-Rmax)was calculated using multicompartment analysis...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29230298/hepatic-paragonimiasis-a-single-center-retrospective-analysis-of-32-cases-in-mainland-china
#2
Xiwen Ye, Xianze Xiong, Nansheng Cheng, Jiong Lu, Yixin Lin
Background: In paragonimiasis, the lungs and pleural cavity are the major target organs, and the central nervous system can also be affected. The liver is an organ in which ectopic paragonimiasis rarely occurs. Because the symptoms and examinations in hepatic paragonimiasis (HP) are not typical, the disease is often misdiagnosed in the clinic. Methods: From February 2008 to March 2015, our department accepted 32 patients who presented with a liver mass upon ultrasound and computed tomography imaging and in whom the source of the mass could not be identified upon numerous further diagnostic tests...
November 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/29224266/-application-of-liver-three-dimensional-visualization-technologies-in-the-treatment-planning-of-hepatic-malignant-tumor
#3
P P Li, Z H Wang, G Huang, Z P Huang, Y Li, J S Ni, H Liu, C H Fang, W P Zhou
Objective: To discuss the application of three dimentional(3D)visualization technologies in treatment plan of hepatic malignant tumor. Methods: The clinical data of 300 patients with liver malignant tumor who received treatment from January 2016 to January 2017 in the Third Department of Hepatic Surgery of Eastern Hepatobiliary Surgery Hospital was retrospectively analyzed in this study, including 221 male and 79 female patients aged from 7 to 76 years with median age of 54 years. The median height was 168 cm (115-183 cm), the median weight was 65 kg (20-105 kg) and the median tumor volume was 142 ml (23-2 493 ml)...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29224260/-ten-years-retrospective-review-of-the-application-of-digital-medical-technology-in-general-surgery-in-china
#4
C H Fang, Y Y Lau, W P Zhou, W Cai
Digital medical technology is a powerful tool which has forcefully promoted the development of general surgery in China. In this article, we reviews the application status of three-dimensional visualization and three-dimensional printing technology in general surgery, introduces the development situation of surgical navigation guided by optical and electromagnetic technology and preliminary attempt to combined with mixed reality applied to complicated hepatectomy, looks ahead the development direction of digital medicine in the era of artificial intelligence and big data on behalf of surgical robot and radiomics...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29224239/personalized-stepwise-vascular-control-during-complex-hepatectomy-involving-hepatocaval-confluence
#5
Lei Dou, Zong-Ping Yu, Hui-Yuan Yang, Ji Ran, Yi-Fa Chen, Xiao-Ping Chen
BACKGROUND: This study introduces an innovative stepwise vascular control technique to address the high risk of massive bleeding from main hepatic veins and the retro-hepatic inferior vena cava during hepatectomy involving hepatocaval confluence. METHODS: From January 2010 to July 2016, 80 patients underwent stepwise vascular occlusion during complex liver resection involving hepatocaval confluence. Relevant clinical data were collected and compared with those obtained in parallel studies...
December 10, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29222964/east-meets-west-east-and-west-pioneers-of-anatomical-right-hepatectomy-period-of-dawn-to-establishment
#6
EDITORIAL
Atsushi Nanashima, Shun-Ichi Ariizumi, Masakazu Yamamoto
Right hepatectomy is a standard anatomical procedure used worldwide, and consists of two important steps: access to the portal pedicle at the hepatic hilus and approach through the right hepatic vein. With interest in the early work in the field of right hepatectomy, we searched for official documents, published not only in English but also non-English languages for insights on the history of the great work conducted by pioneer liver surgeons in the East and West. To discuss anatomical right hepatectomy, it is important to consider several issues, including liver anatomy, other anatomical liver resection procedures, control of vascular in-flow and out-flow, operative procedures or approaches, preoperative management and other related issues...
December 9, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29215843/-influence-of-partial-hepatectomie-on-ammoniumdetoxications-function-of-liver-at-chronic-tetrachlorcarbon-hepatitis
#7
P N Savilov
The purpose. To study the effect of partial hepatectomy (PH) on the main ways of ammonia detoxication in the liver (synthesis of urea and glutamine) in chronic tetrachlorcarbon (CCl4) hepatitis. Methods. The experiments were performed on 165 white outbred rats (females) weighing 180-220 g Chronic CCl4-hepatitis was reproduced by subcutaneous injection of 50% CCl4 solution in olive oil (0.1 ml/100g of body weight,65 days, through the day with two two-week breaks between 6-7 and 13-14 injections). PH conducted electrocautery, removing part of the left lobe of the liver (15-20% by weight of the body) to 65th (and last) day of the introduction of the CCl4...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29212179/impact-of-cavitron-ultrasonic-surgical-aspirator-cusa-and-bipolar-radiofrequency-device-habib-4x-based-hepatectomy-for-hepatocellular-carcinoma-on-tumour-recurrence-and-disease-free-survival
#8
Kai-Wen Huang, Po-Huang Lee, Tomokazu Kusano, Isabella Reccia, Kumar Jayant, Nagy Habib
Background: The aim of this study was to evaluate the oncological outcomes of hepatocellular carcinoma patients undergoing liver resection using cavitron ultrasonic surgical aspirator (CUSA) or radiofrequency (RF) based device Habib-4X.
. Study Design: We prospectively analyzed the data of 280 patients who underwent liver resection for hepatocellular carcinoma at our institution from 2010-2012 with follow up till August 2016. The CUSA was used in the 163 patients whilst Habib-4X in 117 patients...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211918/decellularized-human-placenta-supports-hepatic-tissue-and-allows-rescue-in-acute-liver-failure
#9
Zurab Kakabadze, Anne Kakabadze, David Chakhunashvili, Lika Karalashvili, Ekaterine Berishvili, Yogeshwar Sharma, Sanjeev Gupta
Tissue engineering with scaffolds to form transplantable organs is of wide interest. Decellularized tissues have been tested for this purpose, although supplies of healthy donor tissues, vascular recellularization for perfusion and tissue homeostasis in engineered organs pose challenges. We hypothesized decellularized human placenta will be suitable for tissue engineering. The universal availability and unique structures of placenta for accommodating tissue, including presence of embedded vessels, were major attractions...
December 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29210183/young-plasma-reverses-age-dependent-alterations-in-hepatic-function-through-the-restoration-of-autophagy
#10
Anding Liu, Enshuang Guo, Jiankun Yang, Yan Yang, Shenpei Liu, Xiaojing Jiang, Qi Hu, Olaf Dirsch, Uta Dahmen, Cuntai Zhang, David A Gewirtz, Haoshu Fang
Recent studies showing the therapeutic effect of young blood on aging-associated deterioration of organs point to young blood as the solution for clinical problems related to old age. Given that defective autophagy has been implicated in aging and aging-associated organ injuries, this study was designed to determine the effect of young blood on aging-induced alterations in hepatic function and underlying mechanisms, with a focus on autophagy. Aged rats (22 months) were treated with pooled plasma (1 ml, intravenously) collected from young (3 months) or aged rats three times per week for 4 weeks, and 3-methyladenine or wortmannin was used to inhibit young blood-induced autophagy...
December 5, 2017: Aging Cell
https://www.readbyqxmd.com/read/29209981/the-effect-of-frailty-index-on-early-outcomes-after-combined-colorectal-and-liver-resections
#11
Sophia Y Chen, Miloslawa Stem, Marcelo Cerullo, Susan L Gearhart, Bashar Safar, Sandy H Fang, Matthew J Weiss, Jin He, Jonathan E Efron
BACKGROUND: Although previous studies have examined frailty as a potential predictor of adverse surgical outcomes, little is reported on its application. We sought to assess the impact of the 5-item modified frailty index (mFI) on morbidity in patients undergoing combined colorectal and liver resections. METHODS: Adult patients who underwent combined colorectal and liver resections were identified using the ACS-NSQIP database (2005-2015). The 5-item mFI consists of history of chronic obstructive pulmonary disease, congestive heart failure, hypertension, diabetes, and partial/total dependence...
December 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29209133/anterior-vs-conventional-approach-right-hepatic-resection-for-large-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#12
Jian-Xin Tang, Jin-Jun Li, Rui-Hui Weng, Zi-Ming Liang, Nan Jiang
AIM: To compare the clinical outcomes of right hepatectomy for large hepatocellular carcinoma via the anterior and conventional approach. METHODS: We comprehensively performed an electronic search of PubMed, EMBASE, and the Cochrane Library for randomized controlled trials (RCTs) or controlled clinical trials (CCTs) published between January 2000 and May 2017 concerning the anterior approach (AA) and the conventional approach (CA) to right hepatectomy. Studies that met the inclusion criteria were included, and their outcome analyses were further assessed using a fixed or random effects model...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29209120/laparoscopic-vs-open-hepatectomy-for-hepatolithiasis-an-updated-systematic-review-and-meta-analysis
#13
Hui Li, Jun Zheng, Jian-Ye Cai, Shi-Hui Li, Jun-Bin Zhang, Xiao-Ming Wang, Gui-Hua Chen, Yang Yang, Gen-Shu Wang
AIM: To perform a meta-analysis on laparoscopic hepatectomy VS conventional liver resection for treating hepatolithiasis. METHODS: We conducted a systematic literature search on PubMed, Embase, Web of Science and Cochrane Library, and undertook a meta-analysis to compare the efficacy and safety of laparoscopic hepatectomy VS conventional open liver resection for local hepatolithiasis in the left or right lobe. Intraoperative and postoperative outcomes (time, estimated blood loss, blood transfusion rate, postoperative intestinal function recovery time, length of hospital stay, postoperative complication rate, initial residual stone, final residual stone and stone recurrence) were analyzed systematically...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208318/liver-resection-is-justified-for-patients-with-bilateral-multiple-colorectal-liver-metastases-a-propensity-score-matched-analysis
#14
Kiyohiko Omichi, Junichi Shindoh, Jordan M Cloyd, Takashi Mizuno, Yun Shin Chun, Claudius Conrad, Thomas A Aloia, Ching-Wei D Tzeng, Jean-Nicolas Vauthey
BACKGROUND: Increasingly, patients with multiple colorectal liver metastases (CLM) are surgically treated. Some studies have shown that patients with bilobar and unilobar multiple CLM have similar outcomes, but other have shown that patients with bilobar CLM have worse outcomes after resection. We aimed to compare clinical outcomes of surgical treatment of bilobar and unilobar CLM using propensity score matching. METHODS: The single-institution study included patients who underwent hepatectomy for ≥3 histologically confirmed CLM during 1998-2014...
November 24, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29207941/uneven-acute-non-alcoholic-fatty-change-of-the-liver-after-percutaneous-transhepatic-portal-vein-embolization-in-a-patient-with-hilar-cholangiocarcinoma-a-case-report
#15
Chun-Yi Tsai, Motoi Nojiri, Yukihiro Yokoyama, Tomoki Ebata, Takashi Mizuno, Masato Nagino
BACKGROUND: Portal vein embolization is essential for patients with biliary cancer who undergo extended hepatectomy to induce hypertrophy of the future remnant liver. Over 830 patients have undergone the portal vein embolization at our institution since 1990. Non-alcoholic fatty liver disease is an entity of hepatic disease characterized by fat deposition in hepatocytes. It has a higher prevalence among persons with morbid obesity, type 2 diabetes, and hyperlipidemia. Neither the mechanism of hepatic hypertrophy after portal vein embolization nor the pathophysiology of non-alcoholic fatty liver disease has been fully elucidated...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29205784/thoracic-epidural-analgesia-in-donor-hepatectomy-an-analysis
#16
Archna Koul, Deepanjali Pant, Swetha Rudhravaram, Jayashree Sood
BACKGROUND: To analyze whether supplementation of general anaesthesia with thoracic epidural analgesia (TEA) for right lobe donor hepatectomy is a safe modality of pain relief in terms of changes in postoperative coagulation profile, incidence of epidural catheter related complications and timing of removal of epidural catheter. METHODS: Retrospective analysis of the record of 104 patients who received TEA for right lobe donor hepatectomy was done. Platelet count, INR, ALT and AST were recorded postoperatively till the removal of the epidural catheter...
December 2, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29203284/intermediate-term-survival-and-quality-of-life-outcomes-in-patients-with-advanced-colorectal-liver-metastases-undergoing-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#17
Kerollos Nashat Wanis, Victoria Ardiles, Fernando A Alvarez, Mauro Enrique Tun-Abraham, David Linehan, Eduardo de Santibañes, Roberto Hernandez-Alejandro
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an innovative, 2-staged hepatectomy which has elicited controversy within the international hepatobiliary community. Uptake of ALPPS has been limited due to concerns related to evidence of high morbidity and mortality and scant oncologic and quality of life outcome data and quality of life (Ool). Demonstrating reasonable long-term benefits with a short-term risk is necessary to support more widespread endorsement of ALPPS...
December 1, 2017: Surgery
https://www.readbyqxmd.com/read/29202837/predictive-power-of-splenic-thickness-for-post-hepatectomy-liver-failure-in-hbv-associated-hepatocellular-carcinoma-patients
#18
Xiang Chen, Heng Zou, Li Xiong, Sheng-Fu Huang, Xiong-Ying Miao, Yu Wen
BACKGROUND: The purpose of this case series is to investigate the relationship between splenic thickness (ST) and postoperative outcomes after hepatic resection in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) patients. METHODS: The clinical data of 320 patients with HBV-associated HCC who had undergone liver resection were retrospectively analyzed. The value of ST in predicting postoperative outcomes was evaluated. RESULTS: A total of 320 patients were enrolled in the study...
December 4, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29201802/hepatic-metastasis-from-colorectal-cancer
#19
Alan I Valderrama-Treviño, Baltazar Barrera-Mera, Jesús C Ceballos-Villalva, Eduardo E Montalvo-Javé
The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used. In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29201496/platelets-prime-hematopoietic-and-vascular-niche-to-drive-angiocrine-mediated-liver-regeneration
#20
Koji Shido, Deebly Chavez, Zhongwei Cao, Jane Ko, Shahin Rafii, Bi-Sen Ding
In mammals, the livers regenerate after chemical injury or resection of hepatic lobe by hepatectomy. How liver regeneration is initiated after mass loss remains to be defined. Here, we report that following liver injury, activated platelets deploy SDF-1 and VEGF-A to stimulate CXCR7+ liver sinusoidal endothelial cell (LSEC) and VEGFR1+ myeloid cell, orchestrating hepatic regeneration. After carbon tetrachloride (CCl4) injection or hepatectomy, platelets and CD11b+VEGFR1+ myeloid cells were recruited LSEC, and liver regeneration in both models was impaired in thrombopoietin-deficient (Thpo-/-) mice lacking circulating platelets...
2017: Signal Transduction and Targeted Therapy
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