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https://www.readbyqxmd.com/read/29684806/indocyanine-green-identification-for-tumor-infiltration-or-metastasis-originating-from-hepatocellular-carcinoma
#1
Atsushi Nanashima, Tetsuro Tominaga, Yorihisa Sumida, Shuichi Tobinaga, Takeshi Nagayasu
INTRODUCTION: The indocyanine green-photodynamic eye (ICG-PDE) system is useful to detect small hypervascular liver tumors, hepatocellular carcinoma (HCC), on the liver surface. This system may be also applied to improve determining the location of metastasis or tumor thrombus (TT). We herein report three case reports. ICG was administered preoperatively for functional testing and images of the tumor were observed during hepatectomy using a PDE camera. CASE SERIES: The patient in case 1 exhibited advanced HCC with TT in the portal trunk...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29684001/one-hundred-and-fifteen-cases-of-pure-laparoscopic-living-donor-right-hepatectomy-at-a-single-center
#2
Kwang-Woong Lee, Suk Kyun Hong, Kyung-Suk Suh, Hyo-Sin Kim, Sung-Woo Ahn, Kyung Chul Yoon, Jeong-Moo Lee, Jae-Hyung Cho, Hyeyoung Kim, Nam-Joon Yi
BACKGROUND: The pure laparoscopic approach to donor hepatectomy is being taken more often. However, few centers perform pure laparoscopic donor right hepatectomy (PLDRH) because it requires a high level of surgical skill. Studies reporting initial outcomes of PLDRH may prompt further implementation of the technique and help reduce initial learning curves at other transplant centers. This study reports performance of PLDRH at a single center with extensive experience of adult living donor liver transplantation...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29683437/re-arterialized-rat-partial-liver-transplantation-with-an-in-vivo-vessel-oriented-70-hepatectomy
#3
Xuehai Chen, Rong Yu, Ziqiang Xu, Yan Zhang, Chengyang Liu, Bicheng Chen, Hao Jin
Split liver transplantation and living liver donor liver transplantation were developed in the clinic to utilize liver organs in a more efficient manner. To better understand the mechanism behind these surgical procedures, a rat partial liver transplantation (PLTx) model was established for relevant surgical studies. Because of the complexity of the rat PLTx model, a protocol with detailed descriptions is required. An article published previously reported a protocol in which ex vivo hepatectomy was used to achieve 50% rat PLTx...
April 8, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683188/prediction-of-major-complications-after-hepatectomy-using-liver-stiffness-values-determined-by-magnetic-resonance-elastography
#4
N Sato, A Kenjo, T Kimura, R Okada, T Ishigame, Y Kofunato, T Shimura, K Abe, H Ohira, S Marubashi
BACKGROUND: Liver fibrosis is a risk factor for hepatectomy but cannot be determined accurately before hepatectomy because diagnostic procedures are too invasive. Magnetic resonance elastography (MRE) can determine liver stiffness (LS), a surrogate marker for assessing liver fibrosis, non-invasively. The aim of this study was to investigate whether the LS value determined by MRE is predictive of major complications after hepatectomy. METHODS: This prospective study enrolled consecutive patients who underwent hepatic resection between April 2013 and August 2016...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29679437/preoperative-platelet-count-is-associated-with-increased-risk-of-posthepatectomy-grade-a-liver-failure-in-right-lobe-donors-for-liver-transplantation
#5
Kenji Yoshino, Kojiro Taura, Yoshinobu Ikeno, Yukihiro Okuda, Takahiro Nishio, Gen Yamamoto, Satoru Seo, Shintaro Yagi, Koichiro Hata, Toshimi Kaido, Hideaki Okajima, Shinji Uemoto
Living donor right hepatectomy (LDRH) is a common procedure in adult-to-adult living donor liver transplantation (LDLT), but is associated with a higher risk of posthepatectomy liver failure (PHLF) compared with left hepatectomy because of a smaller remnant. We identified risk factors for PHLF and other complications in LDRH, verified the appropriateness of the criteria, and explored the possibility of adjusting the minimum RLV based on individual risk. Between October 2005 and November 2017, 254 donors undergoing LDRH at Kyoto University Hospital were enrolled...
April 20, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29672888/a-novel-fibroblast-growth-factor-15-dependent-and-bile-acid-independent-promotion-of-liver-regeneration-in-mice
#6
Bo Kong, Runbin Sun, Mingxing Huang, Monica D Chow, Xiao-Bo Zhong, Wen Xie, Yi-Horng Lee, Grace L Guo
The role of intestine-derived factors in promoting liver regeneration after partial hepatectomy (PHx) are not entirely known, but bile acids (BAs) and fibroblast growth factor 15 (Fgf15) that is highly expressed in the mouse ileum could promote hepatocyte proliferation. Fgf15 strongly suppresses the synthesis of BAs and emerging evidence indicates that Fgf15 is important for liver regeneration. The mechanisms by which Fgf15 promotes liver regeneration are unclear, but Fgf15 may do so indirectly by reducing BA levels and/or directly by promoting cell proliferation...
April 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29672305/the-prognostic-prediction-role-of-preoperative-serum-albumin-level-in-patients-with-intahepatic-cholangiocarcinoma-following-hepatectomy
#7
Junyi Shen, Tianfu Wen, Chuan Li, Lvnan Yan, Bo Li, Jiayin Yang
BACKGROUND: There is little information regarding the role of preoperative serum albumin (ALB) in intrahepatic cholangiocarcinoma (ICC) patients who underwent liver resection. METHODS: Clinicopathological characteristics and survival rate of 91 ICC patients who underwent surgery between 2009 and 2013 were included in this study. The optimal cut-off for ALB were determined by plotting the receiver operating characteristics curves of ALB in predicting overall survival (OS) and utilizing the Youden index...
April 19, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29672297/preoperative-controlling-nutritional-status-score-predicts-mortality-after-hepatectomy-for-hepatocellular-carcinoma
#8
Kosei Takagi, Yuzo Umeda, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Takuro Fushimi, Toshiyoshi Fujiwara, Takahito Yagi
BACKGROUND: Preoperative nutritional status is reportedly associated with postoperative outcomes in patients with hepatocellular carcinoma. This study aimed to investigate the significance of the controlling nutritional status (CONUT) score and the prognostic nutritional index (PNI) as predictors of postoperative outcomes. METHODS: We retrospectively reviewed data from 331 patients who underwent hepatectomy for hepatocellular carcinoma between January 2007 and December 2015...
April 19, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29669343/major-hepatectomy-for-colorectal-liver-metastases-in-patients-aged-over-80-a-propensity-score-matching-analysis
#9
Vito De Blasi, Riccardo Memeo, René Adam, Diane Goéré, Daniel Cherqui, Jean Marc Regimbeau, Michel Rivoire, Laura Ornella Perotto, Francis Navarro, Antonio Sa Cunha, Patrick Pessaux
BACKGROUND: The aim of this study was to evaluate the results of major hepatectomies for metastasis in elderly colorectal cancer patients, for whom limited data exist in the literature. METHODS: From January 2006 to January 2013, 3,034 patients underwent hepatectomy for colorectal liver metastasis in 32 French surgical centers. Repeat hepatectomies were excluded from the study. Based on a 1: 4 propensity score matching model, 42 patients aged ≥80 (OG) were matched with 168 patients <80 years (YG) in order to obtain 2 well-balanced and homogeneous groups with regards to therapy and prognostic factors...
April 17, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29666906/radiofrequency-and-microwave-ablation-compared-to-systemic-chemotherapy-and-to-partial-hepatectomy-in-the-treatment-of-colorectal-liver-metastases-a-systematic-review-and-meta-analysis
#10
Martijn R Meijerink, Robbert S Puijk, Aukje A J M van Tilborg, Kirsten Holdt Henningsen, Llenalia Garcia Fernandez, Mattias Neyt, Juanita Heymans, Jacqueline S Frankema, Koert P de Jong, Dick J Richel, Warner Prevoo, Joan Vlayen
PURPOSE: To assess safety and outcome of radiofrequency ablation (RFA) and microwave ablation (MWA) as compared to systemic chemotherapy and partial hepatectomy (PH) in the treatment of colorectal liver metastases (CRLM). METHODS: MEDLINE, Embase and the Cochrane Library were searched. Randomized trials and comparative observational studies with multivariate analysis and/or matching were included. Guidelines from National Guideline Clearinghouse and Guidelines International Network were assessed using the AGREE II instrument...
April 17, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29665076/life-threatening-or-nearly-life-threatening-complications-in-living-liver-donors
#11
Asim Onur, Sami Akbulut, Abuzer Dirican, Burak Isik, Sezai Yilmaz
OBJECTIVE: To determine the relationship between a transplant center's experience and life-threatening or nearly life-threatening complications during living donor hepatectomy (LDH). METHODS: The medical records of 1140 patients who underwent LDH were analyzed. In order to determine the relationship between life-threatening complications and a transplant center's experience, the following comparisons between LDH cases were done: first 100 vs subsequent 100; first 100 vs subsequent 1040; first 200 vs subsequent 940; right hepatectomy vs left hepatectomy, and first 5 years of experience vs subsequent 5 years...
April 17, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29664996/prognostic-impact-of-perihepatic-lymph-node-metastases-in-patients-with-resectable-colorectal-liver-metastases
#12
M Okuno, C Goumard, T Mizuno, S Kopetz, K Omichi, C-W D Tzeng, Y S Chun, J E Lee, J-N Vauthey, C Conrad
BACKGROUND: Although perihepatic lymph node metastases (PLNMs) are known to be a poor prognosticator for patients with colorectal liver metastases (CRLMs), optimal management remains unclear. This study aimed to determine the risk factors for PLNMs, and the survival impact of their number and location in patients with resectable CRLMs. METHODS: Data on patients with CRLM who underwent hepatectomy during 2003-2014 were analysed retrospectively. Recurrence-free (RFS) and overall (OS) survival were calculated according to presence, number and location of PLNMs...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29662835/preoperative-low-muscle-mass-and-low-muscle-quality-negatively-impact-on-pulmonary-function-in-patients-undergoing-hepatectomy-for-hepatocellular-carcinoma
#13
Hisaya Shirai, Toshimi Kaido, Yuhei Hamaguchi, Atsushi Kobayashi, Shinya Okumura, Siyuan Yao, Shintaro Yagi, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Shinji Uemoto
Background: Sarcopenia is a prognostic factor for mortality in digestive surgery. However, the correlation between preoperative cardiopulmonary function and sarcopenia in patients undergoing hepatectomy for hepatocellular carcinoma (HCC) remains unclear. Methods: The present study investigated the impact of preoperative sarcopenia on cardiopulmonary function in 402 patients who underwent first hepatectomy for HCC between April 2005 and April 2015. The quantity and quality of skeletal muscle were evaluated using psoas muscle index (PMI) and intramuscular adipose tissue content (IMAC), respectively, as determined from preoperative computed tomography imaging...
March 2018: Liver Cancer
https://www.readbyqxmd.com/read/29662833/short-term-outcomes-following-hepatectomy-in-elderly-patients-with-hepatocellular-carcinoma-an-analysis-of-10-805-septuagenarians-and-2-381-octo-and-nonagenarians-in-japan
#14
Hiroko Okinaga, Hideo Yasunaga, Kiyoshi Hasegawa, Kiyohide Fushimi, Norihiro Kokudo
Background: As the population is aging, the indication for hepatocellular carcinoma (HCC) resection in patients aged over 80 years will increase. Japan is facing the most aging society worldwide. We examined the safety of hepatectomy in octogenarians and nonagenarians using large-scale data from the Diagnosis Procedure Combination database, a national administrative database in Japan. Method: We conducted a survey to collect data for all inpatients from 2007 and 2012...
March 2018: Liver Cancer
https://www.readbyqxmd.com/read/29662831/the-asia-pacific-consensus-statement-on-laparoscopic-liver-resection-for-hepatocellular-carcinoma-a-report-from-the-7th-asia-pacific-primary-liver-cancer-expert-meeting-held-in-hong-kong
#15
Tan To Cheung, Ho-Seong Han, Wong Hoi She, Kuo-Hsin Chen, Pierce K H Chow, Boon Koon Yoong, Kit Fai Lee, Shoji Kubo, Chung Ngai Tang, Go Wakabayashi
Background: Laparoscopic liver resection has been gaining momentum, and it has become an accepted practice after the two international consensus conferences where experts worked up guidelines to standardize this approach and improve its safety. However, most laparoscopic hepatectomies were performed in patients with liver metastases. The concurrent presence of liver cirrhosis with hepatocellular carcinoma (HCC) poses a great challenge to clinicians trying to establish a routine use of laparoscopic liver resection for HCC...
March 2018: Liver Cancer
https://www.readbyqxmd.com/read/29661564/a-new-technique-for-hepatic-parenchymal-transection-using-an-articulating-bipolar-5-cm-radiofrequency-device-results-from-the-first-100-procedures
#16
Hideo Takahashi, Muhammet Akyuz, Erol Aksoy, Federico Aucejo, Cristiano Quintini, Charles Miller, John Fung, Eren Berber
BACKGROUND: Parenchymal transection(PT) still remains a challenge in liver resection. The outcomes of the first experience of a novel vessel-sealer for hepatic transection were assessed. METHODS: A bipolar articulating vessel-sealer (Caiman® , Aesculap Inc., Center Valley, PA) was used in 100 liver resections through both open (OLR) and laparoscopic (LLR) approaches. All data were prospectively collected into an IRB-approved department database, and clinical, surgical and perioperative parameters were analyzed...
April 13, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29661451/ischemia-with-preconditioning-in-wistar-rats-maintains-mitochondrial-respiration-even-with-mild-hepatocellular-disturbance
#17
R R Tártaro, G L Jorge, A H Dianin, C A F Escanhoela, I F S F Boin
INTRODUCTION: In hepatectomy or liver transplantation, preconditioning is a procedure indicated to protect the organ from ischemia-reperfusion injury (I-R). OBJECTIVE: Evaluate the effect of preconditioning after hepatic I-R in Wistar rats, through mitochondrial respiration, liver histology, and profile. METHOD: Twenty male Wistar rats, weighing on average 307.1 g, were anesthetized with sodium thiopental (25 mg/kg) intravenously and xylazine hydrochloride (30 mg/kg) intramuscularly...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661450/effect-of-hepatic-preconditioning-with-the-use-of-methylene-blue-on-the-liver-of-wistar-rats-submitted-to-ischemia-and-reperfusion
#18
T N de Almeida, J P Victorino, J Bistafa Liu, D Tófoli Queiroz Campos, C Graf, M C Jordani, L A Carneiro d'Albuquerque, K D S Mendes, O Castro-E-Silva
BACKGROUND: The liver may be injured in situations where it is submitted to ischemia, such as partial hepatectomy and liver transplantation. In all cases, ischemia is followed by reperfusion and, although it is essential for the reestablishment of tissue function, reperfusion may cause greater damage than ischemia, an injury characterized as ischemia-reperfusion (I/R) damage. The aim of this work was to analyze the effect of ischemic preconditioning with the use of methylene blue (MB; 15 mg/kg) 5 or 15 minutes before I/R (IRMB5' and IRMB15', respectively) on the hepatic injury occurring after I/R...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29660216/the-prognostic-significance-of-serum-hbeag-on-the-recurrence-and-long-term-survival-after-hepatectomy-for-hepatocellular-carcinoma-a-propensity-score-matching-analysis
#19
Junyi Shen, Jiaye Liu, Chuan Li, Tianfu Wen, Lvnan Yan, Jiayin Yang
The effects of serum hepatitis B e antigen (HBeAg) on the prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy remain controversial. Our aim was to explore the prognostic significance of serum HBeAg on the prognosis of HCC patients using a propensity matching model. Between January 2009 and March 2015, 953 patients with HCC who underwent hepatectomy in West China Hospital were analyzed. Propensity matching analysis was applied and survival analysis was performed using the Kaplan-Meier method...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29658823/totally-laparoscopic-mini-alpps-using-a-novel-approach-of-laparoscopic-assisted-transmesenteric-portal-vein-embolization
#20
Juan Pekolj, Fernando A Alvarez, David Biagiola, Lucas Villegas, Victoria Ardiles, Eduardo de Santibañes
BACKGROUND: The initial mortality rates of associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS) were high. However, recent data from the International Registry show a continuous reduction of early mortality and major morbidity due to risk adjustment in patient selection and less invasive techniques in stage-1 surgery. During the first ALPPS International Consensus in 2015, we introduced a paradigm inversion of ALPPS, the so-called "Mini-ALPPS." METHODS: We combined a partial liver partition with a novel technique of laparoscopic-assisted percutaneous cannulation of the inferior mesenteric vein for intraoperative transmesenteric portal vein embolization...
April 16, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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