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https://www.readbyqxmd.com/read/28806777/a-synthetic-sickness-screen-for-senescence-re-engagement-targets-in-mutant-cancer-backgrounds
#1
Claire J Cairney, Lauren S Godwin, Alan E Bilsland, Sharon Burns, Katrina H Stevenson, Lynn McGarry, John Revie, Jon D Moore, Ceri M Wiggins, Rebecca S Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C Bennett, Masashi Narita, Christopher J Torrance, W Nicol Keith
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack of robust senescence inducing agents and an incomplete understanding of the signalling events underlying this complex process. In order to address this issue we undertook a large-scale morphological siRNA screen for inducers of senescence phenotypes in the human melanoma cell line A375P...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28795227/decrease-in-work-ability-index-and-sickness-absence-during-the-following-year-a-two-year-follow-up-study
#2
Masanori Ohta, Yoshiyuki Higuchi, Masaharu Kumashiro, Hiroshi Yamato, Hisamichi Sugimura
PURPOSE: Using a 2-year follow-up design, we examined whether changes in work ability during 1 year predicted sickness absence in the following year. METHODS: Workers (N = 1408) from the Japanese information technology sector each completed the Work Ability Index (WAI), the Brief Job Stress Questionnaire (BJSQ), and the General Health Questionnaire (GHQ) in 2011 and 2012. Absence data during 2013 was obtained from employees' computerized attendance records. We used psychological distress as evaluated by the GHQ; job stress and job support calculated using the BJSQ; and job title, sex, and age as potential confounding variables...
August 9, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28783203/cumulative-occupational-mechanical-exposures-during-working-life-and-risk-of-sickness-absence-and-disability-pension-prospective-cohort-study
#3
Emil Sundstrup, Åse Marie Hansen, Erik Lykke Mortensen, Otto Melchior Poulsen, Thomas Clausen, Reiner Rugulies, Anne Møller, Lars L Andersen
Objectives The aim of this study was to determine the prospective association of cumulative mechanical exposure during working life with health-related labor market outcomes. Methods This prospective cohort study combines data from 5076 older workers (age 49-63 years) from the Copenhagen Aging and Midlife Biobank with a job exposure matrix and a national register containing information on social transfer payment. By coding individual job histories from the Danish version of ISCO-codes (International Standard Classification of Occupations), we calculated cumulative occupational mechanical exposures from a JEM for ton-years (lifting 1000 kg each day in one year), lifting-years (lifting loads weighing ≥20 kg >10 times each day in one year), kneeling-years (kneeling for one hour each day in one year) and vibration-years (whole-body vibration for one hour each day in one year)...
August 7, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28783202/legislative-change-enabling-use-of-early-part-time-sick-leave-enhanced-return-to-work-and-work-participation-in-finland
#4
Eira Viikari-Juntura, Lauri J Virta, Johanna Kausto, Ilona Autti-Rämö, Kari-Pekka Martimo, Mikko Laaksonen, Taina Leinonen, Kirsti Husgafvel-Pursiainen, Alex Burdorf, Svetlana Solovieva
Objectives The aim of the study was to assess the effectiveness of the use of part-time sick leave at the early (first 12 weeks) stage of work disability due to mental disorder or musculoskeletal disease on sustained return to work (RTW) and overall work participation. Methods In a nation-wide register-based quasi-experimental study, we compared sustained RTW (ie, ≥28 consecutive days at work) and 2-year work participation between the part- and full-time sickness absence (SA) benefit groups (N=1878 in each group) using propensity-score matching...
August 7, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28777709/substance-use-disorder-and-suicide-attempt-among-people-who-report-compromised-health
#5
Jonathan Prince
BACKGROUND: Substance use disorder can increase the risk of suicide attempt. However, the relationship between substance use disorder and suicide attempt has yet to be explored among people who report compromised health, even though sick people are more likely to make an attempt. OBJECTIVES: Among people who report fair or poor health on the National Survey of Drug Use and Health (2006-2014; N = 502,467), I examined whether people with commonly occurring substance use disorders are more likely to attempt suicide than people without substance use disorders...
August 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28749947/the-mediating-role-of-recovery-opportunities-on-future-sickness-absence-from-a-gender-and-age-sensitive-perspective
#6
J S Boschman, A Noor, J K Sluiter, M Hagberg
A lack of sufficient recovery during and after work may help to explain impaired health in the long run. We aimed to increase knowledge on the mediating role of recovery opportunities (RO) during and after work on future sickness absence from a gender- and age-sensitive perspective. We used data on RO from a Swedish national survey in 2011 and linked these to sickness absence (>14 days) two years later among the general working population (N = 7,649). Mediation of the relationship between gender and sickness absence by exposure to RO was studied through linear regression...
2017: PloS One
https://www.readbyqxmd.com/read/28747193/impact-of-improved-recording-of-work-relatedness-in-primary-care-visits-at-occupational-health-services-on-sickness-absences-study-protocol-for-a-randomised-controlled-trial
#7
Salla Atkins, Ulla Ojajärvi, Nina Talola, Mervi Viljamaa, Jaakko Nevalainen, Jukka Uitti
BACKGROUND: Employment protects and fosters health. Occupational health services, particularly in Finland, have a central role in protecting employee health and preventing work ability problems. However, primary care within occupational health services is currently underused in informing preventive activities. This study was designed to assess whether the recording of work ability problems and improvement of follow-up of work-related primary care visits can reduce sickness absences and work disability pensions after 1 year...
July 26, 2017: Trials
https://www.readbyqxmd.com/read/28741256/measuring-work-ability-with-its-antecedents-evaluation-of-the-work-ability-survey
#8
Jan-Bennet Voltmer, Jürgen Deller
Purpose The revised version of the Work Ability Survey (WAS-R) assesses work ability on several sub-scales at the intersection of personal and organizational capacity, thus adding to the measurement of work ability by integrating the holistic model. It, therefore, improves on two features of the current standard measurement tool of work ability, the Work Ability Index (WAI): (1) a ceiling effect and (2) limited detail due to a focus on physical health and personal capacity. Method In two samples (n 1 = 1093, n 2 = 359), psychometric properties and the structure of the WAS-R were analyzed...
July 24, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28739368/andrographolide-induces-oxidative-stress-dependent-cell-death-in-unicellular-protozoan-parasite-trypanosoma-brucei
#9
Malabika Banerjee, Debaprasad Parai, Pranab Dhar, Manab Roy, Rajib Barik, Subrata Chattopadhyay, Samir Kumar Mukherjee
African sleeping sickness is a parasitic disease in humans and livestock caused by Trypanosoma brucei throughout sub-Saharan Africa. Absence of appropriate vaccines and prevalence of drug resistance proclaim that a new way of therapeutic interventions is essential against African trypanosomiasis. In the present study, we have looked into the effect of andrographolide (andro), a diterpenoid lactone from Andrographis paiculata on Trypanosoma brucei PRA 380. Although andro has been recognized as a promosing anti-cancer drug, its usefulness against Trypanosoma spp remained unexplored...
July 21, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28733298/are-there-patient-related-factors-that-influence-sickness-certification-in-patients-with-severe-subjective-health-complaints-a-cross-sectional-exploratory-study-from-different-european-countries
#10
Suzanne L Merkus, Rob Hoedeman, Silje Mæland, Kristel H N Weerdesteijn, Frederieke G Schaafsma, Maud Jourdain, Jean-Paul Canevet, Cédric Rat, Johannes R Anema, Erik L Werner
OBJECTIVES: To develop hypotheses about whether there are patient-related factors that influence physicians' decision-making that can explain why some patients with severe subjective health complaints (SHCs) are more likely to be granted sick leave than others. DESIGN: Exploratory cross-sectional. SETTING: Assessments of patient-related factors after watching nine authentic video recordings of patients with severe SHC from a Norwegian general practice...
July 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28729315/sequence-analysis-to-assess-labour-market-participation-following-vocational-rehabilitation-an-observational-study-among-patients-sick-listed-with-low-back-pain-from-a-randomised-clinical-trial-in-denmark
#11
Louise Lindholdt, Merete Labriola, Claus Vinther Nielsen, Trine Allerslev Horsbøl, Thomas Lund
INTRODUCTION: The return-to-work (RTW) process after long-term sickness absence is often complex and long and implies multiple shifts between different labour market states for the absentee. Standard methods for examining RTW research typically rely on the analysis of one outcome measure at a time, which will not capture the many possible states and transitions the absentee can go through. The purpose of this study was to explore the potential added value of sequence analysis in supplement to standard regression analysis of a multidisciplinary RTW intervention among patients with low back pain (LBP)...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28729307/occupational-class-differences-in-long-sickness-absence-a-register-based-study-of-2-1-million-finnish-women-and-men-in-1996-2013
#12
Johanna Pekkala, Jenni Blomgren, Olli Pietiläinen, Eero Lahelma, Ossi Rahkonen
OBJECTIVES: Sickness absence is consistently higher in lower occupational classes, but attempts to analyse changes over time in socioeconomic differences are scarce. We examined trends in medically certified sickness absence by occupational class in Finland from 1996 to 2013 and assessed the magnitude and changes in absolute and relative occupational class differences. DESIGN: Population-based, repeated cross-sectional study. SETTING: A 70% random sample of Finns aged between 25 and 63 years in the years 1996-2013...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28724317/who-among-patients-with-acquired-brain-injury-returned-to-work-after-occupational-rehabilitation-the-rapid-return-to-work-cohort-study
#13
Randi Wågø Aas, Lise Aasen Haveraaen, Evelien P M Brouwers, Lisebet Skeie Skarpaas
BACKGROUND: Acquired brain injury (ABI) is known to be severely disabling. On average, 40% of employees return to work (RTW) within two years after injury. There is, however, limited research on what might contribute to successful RTW. AIM: To examine factors that might impact the time-to first RTW for patients with ABI, participating in a RTW-program. METHODS: The study was designed as a cohort study of patients on sick leave due to mild or moderate ABI (n = 137)...
July 20, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28717071/anti-mitochondrial-m2-antibodies-enhance-the-risk-of-supraventricular-arrhythmias-in-patients-with-elevated-hepatobiliary-enzyme-levels
#14
Hiroki Konishi, Koji Fukuzawa, Shumpei Mori, Seimi Satomi-Kobayashi, Kunihiko Kiuchi, Atsushi Suzuki, Yoshihiko Yano, Akihiro Yoshida, Ken-Ichi Hirata
Objective Supraventricular arrhythmias are commonly detected in patients with anti-mitochondrial antibody M2 (AMA-M2)-associated myopathy. However, the prevalence of supraventricular arrhythmias in unselected AMA-M2-positive patients and the impact of AMA-M2 on supraventricular arrhythmias have yet to be fully investigated. Methods We analyzed 384 patients (116 men; age, 60 [48-69] years), who underwent AMA-M2 testing following the detection of elevated hepatobiliary enzymes. Supraventricular arrhythmias involving atrial fibrillation, atrial flutter, atrial tachycardia, sick sinus syndrome, and atrial standstill were confirmed by a 12-lead electrocardiogram, 24-hour ambulatory monitoring, and physician-assigned diagnoses within the three years before and two years after the AMA-M2 test...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28713854/forced-migration-in-childhood-are-there-long-term-health-effects
#15
Jan M Saarela, Irma T Elo
Studies on the health of migrants have increased considerably in number in recent years, but little is still known about the long-term health effects associated with forced migration, and particularly for people who were forced to migrate as children. Data shortcomings together with the methodological challenges of studying migrant populations limit the ability to disentangle the roles of various factors that influence migrant health outcomes. Finland provides an unusual opportunity to study long-term health consequences associated with forced migration...
December 2016: SSM—Population Health
https://www.readbyqxmd.com/read/28709405/rehabilitation-access-and-effectiveness-for-persons-with-back-pain-the-protocol-of-a-cohort-study-rehab-bp-drks00011554
#16
Matthias Bethge, Kerstin Mattukat, David Fauser, Wilfried Mau
BACKGROUND: Back pain is one of the most common chronic diseases in Germany and has a major impact on work ability and social participation. The German Pension Insurance (GPI) is the main provider of medical rehabilitation to improve work ability and prevent disability pensions in Germany. However, over half of the persons granted a disability pension have never used a medical rehabilitation service. Furthermore, evidence on the effects of medical rehabilitation in Germany is inconclusive...
July 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28699463/investigating-the-attitudes-of-nurses-who-are-obese
#17
Jane Wills, Muireann Kelly
The prevalence of obesity is higher among nurses than in any other group of healthcare professionals. Obesity is an issue for the nursing workforce because of its effects on work-related sickness absence and productivity, through related conditions such as arthritis and diabetes. Aim To investigate the attitudes, motivations and behaviours of, and the uptake of workplace health initiatives by, nurses who are obese. Method Nurses who are or were obese and who practised in England were recruited at the Royal College of Nursing congress in Glasgow in June 2016...
July 12, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28694388/annexin-a2-supports-pulmonary-microvascular-integrity-by-linking-vascular-endothelial-cadherin-and-protein-tyrosine-phosphatases
#18
Min Luo, Elle C Flood, Dena Almeida, LunBiao Yan, David A Berlin, Paul M Heerdt, Katherine A Hajjar
Relative or absolute hypoxia activates signaling pathways that alter gene expression and stabilize the pulmonary microvasculature. Alveolar hypoxia occurs in disorders ranging from altitude sickness to airway obstruction, apnea, and atelectasis. Here, we report that the phospholipid-binding protein, annexin A2 (ANXA2) functions to maintain vascular integrity in the face of alveolar hypoxia. We demonstrate that microvascular endothelial cells (ECs) from Anxa2(-/-) mice display reduced barrier function and excessive Src-related tyrosine phosphorylation of the adherens junction protein vascular endothelial cadherin (VEC)...
July 10, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28693349/the-wounded-maternity-in-the-fine-arts
#19
Simona Giardina, Maria Rosa Montinari
The historian Fielding Garrison wrote that the history of medicine is the history of mankind, as it encompasses all of human life. This means that the history of medicine encourages us to critically reflect not only on the information (the what, the world of facts) but also invites us to move towards understanding (the who, the world of stories). Next to the historical change, there is the anthropological duration with its baggage of immutable values that art brings to light. The merit of art is to focus not only on the biological aspects, but also on the social and emotional ones that define the mother/child relationship...
July 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28692009/potential-economic-benefits-of-paid-sick-leave-in-reducing-absenteeism-related-to-the-spread-of-influenza-like-illness
#20
Abay Asfaw, Roger Rosa, Regina Pana-Cryan
OBJECTIVE: Most U.S. employers are not required to provide paid sick leave (PSL), and there is limited information on the economic return of providing PSL. We estimated potential benefits to employers of PSL in reducing absenteeism related to the spread of influenza-like illness (ILI). METHODS: We used nationally representative data and a negative binomial random effects model to estimate the impact of PSL in reducing overall absence due to illness or injury. We used published data to compute the share of ILI from the total days of absence, ILI transmission rates at workplaces, wages, and other parameters...
July 6, 2017: Journal of Occupational and Environmental Medicine
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