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Sickness Absence

Kiminori Kurashima, Takayuki Sekimoto, Tsukasa Oda, Tsuyoshi Kawabata, Fumio Hanaoka, Takayuki Yamashita
Growth of precancerous and cancer cells relies on their tolerance of oncogene-induced replication stress (RS). Translesion synthesis (TLS) plays an essential role in cellular tolerance of various types of RS and bypasses replication barriers by employing specialized polymerases. However, limited information is available about the role of TLS polymerases in oncogene-induced RS. Here, we report that Polη, a Y-family TLS polymerase, promotes cellular tolerance of Myc-induced RS. Polη was recruited to Myc-induced RS sites, and Polη depletion enhanced the Myc-induced slowing and stalling of replication forks and the subsequent generation of double-strand breaks (DSBs)...
May 18, 2018: Journal of Cell Science
Maja H Fisker, Tove Agner, Jennifer A Sørensen, Søren G Vejlstrup, Jane Lindschou, Christian Gluud, Per Winkel, Jens P Bonde, Niels E Ebbehøj
BACKGROUND: Sickness absence in hand eczema patients has been associated with stress rather than disease severity, indicating that personal aspects regarding hand eczema should be investigated further. OBJECTIVES: To examine whether patient education vs treatment as usual can influence behaviour and knowledge regarding skin protection and care, as well as personal resources, in patients with occupational hand eczema. METHODS: PREVEX is an individually randomized clinical trial investigating the 1-year effects of a simple, low-cost group-counselling programme vs treatment as usual for patients with notified occupational hand eczema...
May 17, 2018: Contact Dermatitis
Johan Høy Jensen, Esben Meulengracht Flachs, Janne Skakon, Naja Hulvej Rod, Jens Peter Bonde
OBJECTIVES: We investigated work-unit exit, total and long-term sickness absence following organisational change among public healthcare employees. METHODS: The study population comprised employees from the Capital Region of Denmark (n=14 388). Data on reorganisation at the work-unit level (merger, demerger, relocation, change of management, employee layoff or budget cut) between July and December 2013 were obtained via surveys distributed to the managers of each work unit...
May 14, 2018: Occupational and Environmental Medicine
Christina Blomdahl, Suzanne Guregård, Marie Rusner, Helle Wijk
OBJECTIVE: This study investigated the effects of manual-based Phenomenological Art Therapy for individuals living with depression in addition to treatment as usual (PATd/TAU) compared with only treatment as usual (TAU) for individuals diagnosed with moderate to severe depression. METHOD: 79 adults (men = 29.1%) were included in this randomized-controlled-trial (RCT), multicenter study in Sweden with an intention-to-treat design. Participants were randomized into either the PATd/TAU-group (n = 43) or TAU-group (n = 36)...
May 14, 2018: Psychiatric Rehabilitation Journal
Hiroki Maita, Tadashi Kobayashi, Hiroshi Osawa, Hiroyuki Kato
OBJECTIVE: To elucidate the accuracy and optimal cut-off point of self-diagnosis and clinical symptoms of seasonal influenza compared with rapid influenza diagnostic tests as the reference standard, we conducted a cross sectional observational study at a rural clinic in Japan. METHODS: Data during three influenza seasons (December 2013 to April 2016) were retrospectively collected from the medical records and pre-examination sheets of 111 patients aged >11 years (mean age 48...
2018: PloS One
Laura Salonen, Jenni Blomgren, Mikko Laaksonen, Mikko Niemelä
OBJECTIVES: The objective of the study was to examine diagnosis-specific sickness absences of different lengths as predictors of disability retirement in different occupational classes. DESIGN: Register-based prospective cohort study up to 8 years of follow-up. PARTICIPANTS: A 70% random sample of the non-retired Finnish population aged 25-62 at the end of 2006 was included (n=1 727 644) and linked to data on sickness absences in 2005 and data on disability retirement in 2007-2014...
May 9, 2018: BMJ Open
Chantelle Murley, Olof Mogard, Michael Wiberg, Kristina Alexanderson, Korinna Karampampa, Emilie Friberg, Petter Tinghög
OBJECTIVES: To describe how disposable income (DI) and three main components changed, and analyse whether DI development differed from working-aged people with multiple sclerosis (MS) to a reference group from 7 years before to 4 years after diagnosis in Sweden. DESIGN: Population-based cohort study, 12-year follow-up (7 years before to 4 years after diagnosis). SETTING: Swedish working-age population with microdata linked from two nationwide registers...
May 9, 2018: BMJ Open
Lars L Andersen, Sannie V Thorsen, Mari-Ann Flyvholm, Andreas Holtermann
Background: The working environment plays an important role in public health. This study investigates the risk for long-term sickness absence (LTSA) from the combination of factors related to physical work demands. Methods: Employees (n = 22 740) of the general population (the Danish Work Environment & Health study 2012) were followed for two years in the Danish Register for Evaluation of Marginalisation. Using Cox regression analyses we determined the risk of LTSA from four factors; (i) physical work demands, (ii) physical exertion during work, (iii) fatigue after work and (iv) work-limiting pain...
May 5, 2018: European Journal of Public Health
Anne-Marthe R Indregard, Stein Knardahl, Morten B Nielsen
Health- and social workers are frequently exposed to emotionally demanding work situations that require emotion regulation. Studies have demonstrated a direct relationship between emotion regulation and health complaints and sickness absence. In order to prevent health complaints and to reduce sickness absence among health- and social workers, there is need for greater attention to mechanisms explaining when and how emotionally demanding work situations are related to employee health and sickness absence. The overarching aim of this study was therefore to examine the moderating role of generalized self-efficacy on the association between emotional dissonance, employee health (mental distress and exhaustion), and registry based sickness absence...
2018: Frontiers in Psychology
J Rantonen, J Karppinen, A Vehtari, S Luoto, E Viikari-Juntura, M Hupli, A Malmivaara, S Taimela
BACKGROUND: We assessed the effectiveness of three interventions that were aimed to reduce non-acute low back pain (LBP) related symptoms in the occupational health setting. METHODS: Based on a survey (n = 2480; response rate 71%) on LBP, we selected a cohort of 193 employees who reported moderate LBP (Visual Analogue Scale VAS > 34 mm) and fulfilled at least one of the following criteria during the past 12 months: sciatica, recurrence of LBP ≥ 2 times, LBP ≥ 2 weeks, or previous sickness absence...
May 8, 2018: BMC Public Health
Sarah Dorrington, Emmert Roberts, Arnstein Mykletun, Stephani Hatch, Ira Madan, Matthew Hotopf
OBJECTIVES: The fit note, introduced in England, Wales and Scotland in 2010, was designed to change radically the sickness certification process from advising individuals on their inability to work to advising them on what they could do if work could be adapted. Our review aimed to evaluate the following: (1) Is the 'maybe fit' for work option being selected for patients? (2) Are work solutions being recommended? (3) Has the fit note increased return to work? (4) Has the fit note reduced the length of sickness absence? We considered the way in which outcomes vary according to patient demographics including type of health problem...
May 7, 2018: Occupational and Environmental Medicine
Thomas Johansen, Thomas Lund, Chris Jensen, Anne-Mette Hedeager Momsen, Monica Eftedal, Irene Øyeflaten, Tore N Braathen, Christina M Stapelfeldt, Ben Amick, Merete Labriola
BACKGROUND: A healthy and productive working life has attracted attention owing to future employment and demographic challenges. OBJECTIVE: The aim was to translate and adapt the Work Role Functioning Questionnaire (WRFQ) 2.0 to Norwegian and Danish. METHODS: The WRFQ is a self-administered tool developed to identify health-related work limitations. Standardised cross-cultural adaptation procedures were followed in both countries' translation processes...
2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
E-L Petersson, C Wikberg, J Westman, N Ariai, S Nejati, C Björkelund
BACKGROUND: Depression reduces individuals' function and work ability and is associated with both frequent and long-term sickness absence. OBJECTIVE: Investigate if monitoring of depression course using a self-assessment instrument in recurrent general practitioner (GP) consultations leads to improved work ability, decreased job strain, and quality of life among primary care patients. METHODS: Primary care patients n = 183, who worked...
May 1, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
Vilde Hoff Bernstrøm
BACKGROUND: While long working hours seem to lead to impaired health, several studies have also shown that long working hours are related to lower levels of sickness absence. Previous studies on the relationship between long working hours and sickness absence have compared those who work long hours to those who do not, looking only at between-individual correlations. Those results might therefore reflect relatively stable differences between employees who typically work long hours and employees who typically do not...
May 2, 2018: BMC Public Health
Rüdiger Zwerenz, Katja Böhme, Astrid Wirth, Nicole Labitzke, Sergei Pachtchenko, Manfred E Beutel
BACKGROUND: In a previous RCT we established the efficacy of the psychodynamic online aftercare programme 'GSA-Online' ('Health Training Stress Management at the Workplace') for rehabilitants with work-related stress facing return to work after long-term sickness absence. The purpose of this trial is to implement it into routine care. METHODS/DESIGN: The study is performed in rehabilitation clinics with patients of different medical indications (psychosomatic, orthopedic and cardiological diseases)...
May 2, 2018: BMC Health Services Research
Mette Jensen Stochkendahl, Ole Kristoffer Larsen, Casper Glissmann Nim, Iben Axén, Julia Haraldsson, Ole Christian Kvammen, Corrie Myburgh
Background: Despite extensive publication of clinical guidelines on how to manage musculoskeletal pain and back pain in particular, these efforts have not significantly translated into decreases in work disability due to musculoskeletal pain. Previous studies have indicated a potential for better outcomes by formalized, early referral to allied healthcare providers familiar with occupational health issues. Instances where allied healthcare providers of comparable professional characteristics, but with differing practice parameters, can highlight important social and organisational strategies useful for informing policy and practice...
2018: Chiropractic & Manual Therapies
Sylwia Zielińska, Anna Jezierska-Domaradzka, Magdalena Wójciak-Kosior, Ireneusz Sowa, Adam Junka, Adam M Matkowski
As antique as Dioscorides era are the first records on using Chelidonium as a remedy to several sicknesses. Inspired by the " signatura rerum " principle and an apparent ancient folk tradition, various indications were given, such as anti-jaundice and cholagogue, pain-relieving, and quite often mentioned-ophthalmological problems. Central and Eastern European folk medicine has always been using this herb extensively. In this region, the plant is known under many unique vernacular names, especially in Slavonic languages, associated or not with old Greek relation to "chelidon"-the swallow...
2018: Frontiers in Pharmacology
Rune Hoff, Karina Corbett, Ingrid S Mehlum, Ferdinand A Mohn, Petter Kristensen, Therese N Hanvold, Jon M Gran
BACKGROUND: Completing upper secondary education is associated with higher work participation and less health-related absence from work. Although these outcomes are closely interrelated, most studies focus on single outcomes, using cross-sectional designs or short follow-up periods. As such, there is limited knowledge of the long-term outcomes, and how paths for completers and non-completers unfold over time. In this paper, we use multi-state models for time-to-event data to assess the long-term effects of completing upper secondary education on employment, tertiary education, sick leave, and disability pension over twelve and a half years for young men...
April 27, 2018: BMC Public Health
J C López López, M Ballesteros Polo, M Sampere Valero, R Sacristán Nieto, S Alguacil García, A Ruiz Julian, E Santos Avila, S García Rubia, B López Costa, J M Martínez Martínez
INTRODUCTION: Different countries have shown an inverse relationship between unemployment rates (UR) and indicators of sickness absence during periods of economic recession. OBJECTIVE: To evaluate the relationship between indicators of sickness absence and unemployment in Spain during 2009-2015. METHODS: We obtained incidence and absenteeism rates of non-work related sickness absence (NWSA) from Social Security data, and UR from the National Institute of Statistics...
April 2018: Archivos de Prevención de Riesgos Laborales
Jisha Mathew, Chandrakala Bada Shekarappa, Suman Padubidri Nanyam Rao
Objective: The study was to determine the correlation of Perfusion Index (PI) and Clinical Risk Index for Babies (CRIB) score, in assessing the severity of illness in sick neonates. Methods: This was a cross-sectional study conducted at a tertiary care Neonatal Intensive Care Unit (NICU). All eligible neonates, both term and preterm, admitted to the high-dependency unit of the NICU were included, after parental consent. Relevant details of history and examination were collected with a structured proforma...
April 18, 2018: Journal of Tropical Pediatrics
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