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Radomized control trial

Kalakonas Apostolos, Kotsovolis Georgios, Chalkeidis Omiros, Triantafyllou Christos
BACKGROUND: Ropivacaine is commonly used as local anesthetic for postoperative analgesia through an epidural catheter. Data show that several adjuvants influence the analgesic effect of local anesthetic potency. OBJECTIVE: The aim of the study was to compare fentanyl and clonidine as adjuvants to 1.5 mg ml(-1) ropivacaine in terms of motor blockade, pain relief and side effects. METHODS: In this single center, randomized, clinical trial, 52 patient scheduled for arthroscopic anterior cruciate ligament reconstruction were radomly allocated in two groups...
October 2011: Middle East Journal of Anesthesiology
Xiaomei Zeng, Zhixi Li, Mei Hou
BACKGROUND AND OBJECTIVE: The third generation single-agent drug has been recommended as a first-line chemotherapy for elderly patients with advanced non-small cell lung cancer (NSCLC). The aim of the current radomized trial is to compare the clinical efficacy and toxicities of single-agent paclitaxel liposome versus paclitaxel liposome plus oxaliplatin as a first-line chemotherapy for elderly patients. METHODS: Sixty-nine advanced NSCLC patients from July 2008 to August 2010, confirmed with pathology or cytology and had never received treatment, were randomly divided into two groups...
February 2012: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Yuxiu Liu, Chen Yao, Feng Chen, Gaokui Zhang, Jielai Xia, Qiquang Chen, Binghua Su
OBJECTIVE: To introduce some methods of safety assessment in randomized controlled clinical trials. METHODS: Recent advances and current parctice in normalized safety assessment were reviewed and relevant data analyzed. RESTULTS: The statistical issues including analysis and presentation of adverse events data and laboratory data were involved and summed up. CONCLUSION: With the progressive development of randomized controlled clinical trials in China, the methods introduced in this paper are sure to prove of consultative value for the safety assessment...
January 2004: Zhonghua Nan Ke Xue, National Journal of Andrology
W Londong, V Londong, R Prechtl, A Schwanner
Two possibilities of an inhibition of gastric acid secretion are compared in regard to effectiveness and side effects. Combined i.v. bolus injection of 0.3 mg/kg cimetidine caused almost complete inhibition of peptone-stimulated acid secretion in normal volunteers and duodenal ulcer patients-radomized and double blind investigated-to the same extent as high dose secretin (3 CU/kg/h i.v. infusion) in normal volunteers. Postprandial gastrin was unchanged by combined drug application, but was suppressed by secretin...
June 1980: Zeitschrift Für Gastroenterologie
L J Haywood
Previously reported data document that efficacy of beta-adrenergic antagonists in lowering mortality rates after acute myocardial infarction. Similarly, the higher observed mortality rates among blacks in the Beta-Blocker Heart Attack Trial (BHAT) have been addressed. In this report, we further emphasize the apparent role of prior high blood pressure in the high risk profile of black patients radomized in the BHAT and the similarity in response to therapy to other high risk patients in this study.
November 1989: American Journal of Hypertension
S W Fletcher, F A Appel, M A Bourgeois
A radomized controlled trial was conducted in a metropolitan teaching hospital to determine whether improving follow-up of emergency room patients who had hypertension led to improvements in their medical care and blood pressure control. One hundred fourty four patients were randomly assigned into an intervention group and a control group. In the former, a follow-up clerk assigned patients in returning for follow-up care. Eighty-four percent of patients in this group and 63% of control patients returned to the clinic (P less than 0...
July 21, 1975: JAMA: the Journal of the American Medical Association
M Staquet
The results of non-randomized clinical trials in urological cancer are often contradictory because of the selection of patients which is usually biased. Such data cannot be used for planning a logical therapy for the future patients. In urological cancer, radomized controlled trials are few. Moreover, antimitotic chemotherapy has not been adequately tried.
1976: European Urology
I Reicansky, T B Conradson, S Holmberg, L Rydén, A Waldenström, B Wennerblom
Patients with acute myocardial infarction were allocated to two groups according to a double blind-system of radomization. The patients (n = 18) in one of the groups received digoxin intravenously as an injection of 0.01 mg. per kilogram of body weight during 10 minutes. The patients in the other group (n = 15) received saline and served as controls. A continuous ECG record was obtained from each patient during 1 hour preceding the administration of digoxin or saline and was continued for 3 hours following the injection...
June 1976: American Heart Journal
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