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https://www.readbyqxmd.com/read/27914706/vascular-calcification-in-chronic-kidney-disease-different-bricks-in-the-wall
#1
REVIEW
Marc Vervloet, Mario Cozzolino
A high prevalence of vascular calcification (VC) and a high incidence of cardiovascular events are two key complications of chronic kidney disease. Since most observational studies found a positive association between these two complications, a causal relationship has been assumed. If so, this would render VC a target of therapy. Recent studies, however, suggested this assumption might be an oversimplification. The fundamental aspects of these recent studies are two-fold. The first novel insight is that VC is not a single entity...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27863896/-chronic-kidney-disease-and-dyslipidaemia
#2
Vicente Pascual, Adalberto Serrano, Juan Pedro-Botet, Juan Ascaso, Vivencio Barrios, Jesús Millán, Xavier Pintó, Aleix Cases
Chronic kidney disease (CKD) has to be considered as a high, or even very high risk cardiovascular risk condition, since it leads to an increase in cardiovascular mortality that continues to increase as the disease progresses. An early diagnosis of CKD is required, together with an adequate identification of the risk factors, in order to slow down its progression to more severe states, prevent complications, and to delay, whenever possible, the need for renal replacement therapy. Dyslipidaemia is a factor of the progression of CKD that increases the risk in developing atherosclerosis and its complications...
November 15, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27825313/using-pharmacists-to-improve-risk-stratification-and-management-of-stage-3a-chronic-kidney-disease-a-feasibility-study
#3
Alex R Chang, Michael Evans, Christina Yule, Larissa Bohn, Amanda Young, Meredith Lewis, Elisabeth Graboski, Bethany Gerdy, William Ehmann, Jonathan Brady, Leah Lawrence, Natacha Antunes, Jamie Green, Susan Snyder, H Lester Kirchner, Morgan Grams, Robert Perkins
BACKGROUND: Measurement of albuminuria to stratify risk in chronic kidney disease (CKD) is not done universally in the primary care setting despite recommendation in KDIGO (Kidney Disease Improving Global Outcomes) guidelines. Pharmacist medication therapy management (MTM) may be helpful in improving CKD risk stratification and management. METHODS: We conducted a pragmatic, cluster-randomized trial using seven primary care clinic sites in the Geisinger Health System to evaluate the feasibility of pharmacist MTM in patients with estimated glomerular filtration rate (eGFR) 45-59 ml/min/1...
November 8, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27749383/improving-treatment-for-patients-with-chronic-kidney-disease
#4
Kendra Thomsen, Kim Zuber, Jane Davis, Greg Thomas
OBJECTIVE: Kidneys in a Box (KIB) was developed to identify the effect of a performance improvement CME (PI-CME) project on the management of patients with diabetes who are at risk for chronic kidney disease (CKD). The program provided nonnephrology practitioners with research-based interventions known to slow CKD progression. METHODS: PAs were given the KIB tool kit, which described the scope of CKD identified high-risk diagnoses such as diabetes, and listed six modifiable risk factors that have been shown to slow progression of diabetic kidney disease when implemented...
November 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/27729238/associations-between-cardiovascular-disease-risk-factors-and-il-6-and-hscrp-levels-in-the-elderly
#5
Paweł Nadrowski, Jerzy Chudek, Michał Skrzypek, Monika Puzianowska-Kuźnicka, Małgorzata Mossakowska, Andrzej Więcek, Tomasz Zdrojewski, Tomasz Grodzicki, Krystyna Kozakiewicz
BACKGROUND: Age-related diseases, including cardiovascular diseases (CVD) may be stimulated by microinflammation, marked by increased level of IL-6 and high-sensitivity CRP (hsCRP). We aimed to investigate whether aging "per se" independently contributesto themicroinflammation,inadditionto traditional and novel CVD risk factors. METHODS/RESULTS: The research sample included 4979 participants from PolSenior Study, aged over 65years. The study consisted of threevisitsandincludedquestionnairesurvey,geriatricassessmentandblood/urinesamplingin4101 participants (83...
October 8, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27697414/delphi-consensus-on-the-diagnosis-and-management-of-dyslipidaemia-in-chronic-kidney-disease-patients-a-post-hoc-analysis-of-the-diana-study
#6
Aleix Cases Amenós, Juan Pedro-Botet Montoya, Vicente Pascual Fuster, Vivencio Barrios Alonso, Xavier Pintó Sala, Juan F Ascaso Gimilio, Jesús Millán Nuñez-Cortés, Adalberto Serrano Cumplido
BACKGROUND AND OBJECTIVES: This post hoc study analysed the perception of the relevance of chronic kidney disease (CKD) in dyslipidaemia screening and the choice of statin among primary care physicians (PCPs) and other specialists through a Delphi questionnaire. METHODS: The questionnaire included 4blocks of questions concerning dyslipidaemic patients with impaired carbohydrate metabolism. This study presents the results of the impact of CKD on screening and the choice of statin...
November 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27695357/update-on-current-management-of-chronic-kidney-disease-in-patients-with-hiv-infection
#7
REVIEW
Nina E Diana, Saraladevi Naicker
The prevalence of HIV-associated chronic kidney disease (CKD) varies geographically and depends on the definition of CKD used, ranging from 4.7% to 38% globally. The incidence, however, has decreased with the use of effective combined antiretroviral therapy (cART). A wide variety of histological patterns are seen in HIV-associated kidney diseases that include glomerular and tubulointerstitial pathology. In resource-rich settings, there has been a plateau in the incidence of end-stage renal disease secondary to HIV-associated nephropathy (HIVAN)...
2016: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/27664802/influence-of-late-vascular-inflammation-on-long-term-outcomes-among-patients-undergoing-implantation-of-drug-eluting-stents-role-of-c-reactive-protein
#8
Masanori Shiba, Hideki Itaya, Raisuke Iijima, Masato Nakamura
BACKGROUND: Elevation of C-reactive protein (CRP) as a marker of vascular inflammation at a late phase of drug-eluting stent (DES) implantation may predict subsequent major adverse cardiac events (MACE). METHODS AND RESULTS: In 1234 consecutive patients undergoing DES implantation, CRP was measured both before (baseline) and 8 to 12 months after (late phase) stenting, and the relationship between elevation of CRP (>2.0 mg/L) and subsequent MACE (all cause death, nonfatal myocardial infarction, target lesion revascularization, and other additional revascularization) was assessed...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27660844/statins-in-chronic-kidney-disease-when-and-when-not-to-use-them
#9
Nosratola D Vaziri, Deborah A Anzalone, Julia Catini
This supplement reviews the evidence from clinical trials for the appropriate use of statins in patients with Chronic kidney disease (CKD).
August 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27650472/combination-drug-versus-monotherapy-for-the-treatment-of-autosomal-dominant-polycystic-kidney-disease
#10
Jacek Rysz, Anna Gluba-Brzózka, Beata Franczyk, Maciej Banach, Piotr Bartnicki
INTRODUCTION: Despite progress in the understanding of pathogenetic mechanisms of organ cyst formation in autosomal dominant polycystic kidney disease, current treatment methods are insufficient. Experimental studies and clinical trials target at inhibition of cysts development and to slowing CKD progression. AREAS COVERED: The purpose of this analysis is to overview available literature regarding treatment of ADPKD. The most important recent events concerning ADPKD treatment are: the results of TEMPO 3/4 study and the registration of tolvaptan in the treatment of patients with CKD stage I-III and rapidly progressive ADPKD by EMA...
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27586450/eligibility-for-statin-treatment-in-korean-subjects-with-reduced-renal-function-an-observational-study
#11
Byung Sub Moon, Jongho Kim, Ji Hyun Kim, Young Youl Hyun, Se Eun Park, Hyung Geun Oh, Cheol Young Park, Won Young Lee, Ki Won Oh, Kyu Beck Lee, Hyang Kim, Sung Woo Park, Eun Jung Rhee
BACKGROUND: The purpose of this study was to investigate the relationship between statin eligibility and the degree of renal dysfunction using the Adult Treatment Panel (ATP) III and the American College of Cardiology (ACC)/American Heart Association (AHA) guidelines in Korean adults. METHODS: Renal function was assessed in 18,746 participants of the Kangbuk Samsung Health Study from January 2011 to December 2012. Subjects were divided into three groups according to estimated glomerular filtration rate (eGFR): stage 1, eGFR ≥90 mL/min/1...
September 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27570749/preventive-effect-of-atorvastatin-80-mg-on-contrast-induced-nephropathy-after-angiography-in-high-risk-patients-double-blind-randomized-clinical-trial
#12
Arezoo Khosravi, Mitra Dolatkhah, Hesam Sadat Hashemi, Zohreh Rostami
BACKGROUND: Contrast-induced nephropathy (CIN) is one of the most important complications of angiography in patients with chronic kidney disease (CKD) or diabetes mellitus. The prevention of CIN can decrease therapeutic costs and hospital stays. There is controversy in the literature over the preventive effect of statins on CIN. OBJECTIVES: This study was designed to evaluate the preventive effect of atorvastatin on CIN after angiography in CKD and diabetic patients...
May 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27456102/chronic-kidney-disease-and-cardiovascular-risk-modification
#13
Jerry Fan, Hasan Salameh
BACKGROUND: Chronic kidney disease (CKD) accounts for a significant proportion of the morbidity and mortality in the United States. CKD is defined as glomerular filtration rate (GFR) <60ml/min/1.73m2 or clear evidence of renal damage from biopsy. All-cause cardiovascular risk increases with decreasing GFR. Clinically, detection of CKD is through changes in creatinine clearance which estimates GFR, an indicator of kidney function. We reviewed conventional and nonconventional cardiovascular risk factors associated with CKD...
July 22, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27454090/effect-of-cholesterol-lowering-treatment-on-plasma-markers-of-endothelial-dysfunction-in-chronic-kidney-disease
#14
Angelo Zinellu, Salvatore Sotgia, Arduino A Mangoni, Elisabetta Sotgiu, Sara Ena, Andrea E Satta, Ciriaco Carru
The elevated cardiovascular morbidity and mortality in chronic kidney disease (CKD) is linked with endothelial dysfunction secondary to the pro-inflammatory and pro-oxidative state typical of this pathology. In consideration of the well-known pleiotropic effect of statins, we investigated the effect of cholesterol lowering treatment on endothelial dysfunction markers (MED), asymmetric dimethylarginine (ADMA), vascular cell (VCAM) and intercellular (ICAM) adhesion molecule. Plasma MED concentrations, inflammation and oxidative stress indices [Kynurenine/Tryptophan (Kyn/Trp) ratio, malondialdehyde (MDA) and allantoin/uric acid (All/UA) ratio] were measured in 30 CKD patients randomized to three cholesterol lowering regimens for 12 months (simvastatin 40mg/day, ezetimibe/simvastatin 10/20mg/day, or ezetimibe/simvastatin 10/40mg/day)...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27438893/pcsk9-in-diabetic-kidney-disease
#15
Usama Elewa, Beatriz Fernández-Fernández, Ignacio Mahillo-Fernández, Catalina Martin-Cleary, Ana Belen Sanz, Maria D Sanchez-Niño, Alberto Ortiz
BACKGROUND: Chronic Kidney Disease (CKD) and, specifically, diabetic kidney disease (DKD)+, is among the fastest increasing causes of death worldwide. A better understanding of the factors contributing to the high mortality may help design novel monitoring and therapeutic approaches, since protection offered by statins in CKD patients is not satisfactory. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) promotes hypercholesterolemia and may be targeted therapeutically. Adding anti-PCSK9 agents to standard lipid lowering therapy further reduces the incidence of cardiovascular events...
September 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27392909/effects-of-atorvastatin-on-renal-function-in-patients-with-dyslipidemia-and-chronic-kidney-disease-assessment-of-clinical-usefulness-in-ckd-patients-with-atorvastatin-asuca-trial
#16
Genjiro Kimura, Masato Kasahara, Kenji Ueshima, Sachiko Tanaka, Shinji Yasuno, Akira Fujimoto, Toshiya Sato, Miyuki Imamoto, Shinji Kosugi, Kazuwa Nakao
BACKGROUND: Dyslipidemia is a risk factor for the progression of chronic kidney disease (CKD). While conventional lipid lowering therapy provides a benefit to CKD management, the effect of statins on eGFR remains unclear. METHODS: A prospective, multi-center, open-labeled, randomized trial. Total of 349 CKD patients with hyperlipidemia were randomized into 2 groups, and followed for 2 years. Group A included patients who were treated with atorvastatin. Group C were treated with conventional lipid lowering drugs other than statin...
July 8, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27378232/relative-importance-of-the-determinants-of-serum-levels-of-25-hydroxy-vitamin-d-in-patients-with-chronic-kidney-disease
#17
Fernando Caravaca-Fontán, Boris Gonzales-Candia, Enrique Luna, Francisco Caravaca
INTRODUCTION: The cause of vitamin D deficiency in chronic kidney disease (CKD) is probably multi-factorial; however, the relative importance of each potential determinant is uncertain. AIMS: To determine factors associated with serum levels of 25-hydroxy vitamin D (25OHD) and their relative importance in a cohort of pre-dialysis CKD patients. MATERIAL AND METHODS: Incident patients admitted to a CKD outpatient clinic were included. Those who were receiving vitamin D supplements or anticonvulsants were excluded...
July 1, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27324678/treatment-of-hyperlipidemia-changes-with-level-of-kidney-function-rationale
#18
REVIEW
Shubha Ananthakrishnan, George A Kaysen
Lipoprotein abnormalities such as low levels of high-density lipoprotein (HDL) and high triglycerides (TGs), associated with the metabolic syndrome, are also associated with subsequent decline in kidney function. Patients with end-stage kidney disease also exhibit low HDL and high TGs and a modest reduction in low-density lipoprotein (LDL), although the mechanisms responsible for these changes differ when patients with end-stage kidney disease are compared with those having metabolic syndrome with normal kidney function, as do lipoprotein structures...
July 2016: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/27296703/mortality-and-renal-replacement-therapy-after-renal-artery-stent-placement-for-atherosclerotic-renovascular-disease
#19
Sanjay Misra, Ankaj Khosla, Jake Allred, William S Harmsen, Stephen C Textor, Michael A McKusick
PURPOSE: To identify risk factors for progression to renal replacement therapy (RRT) and all-cause mortality in patients who underwent renal artery (RA) stent placement for atherosclerotic renal artery stenosis (RAS). MATERIALS AND METHODS: A retrospective study from June 1996 to June 2009 identified 1,052 patients who underwent RA stent placement. Glomerular filtration rate at time of RA stent placement was estimated from serum creatinine level and divided into chronic kidney disease (CKD) stages 1-5...
August 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27274830/incident-chronic-kidney-disease-trends-in-management-and-outcomes
#20
Robert M Perkins, Alex R Chang, Kenneth E Wood, Josef Coresh, Kunihiro Matsushita, Morgan Grams
BACKGROUND: Management trends in early chronic kidney disease (CKD) and their associations with clinical outcomes have not previously been reported. METHODS: We evaluated incident (Stage G3A) CKD patients from an integrated health care system in 2004-06, 2007-09 and 2010-12 to determine adjusted trends in screening (urinary protein quantification), treatment [prescription for angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB), and statin] and nephrology referral...
June 2016: Clinical Kidney Journal
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