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Biomarkers CKD

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https://www.readbyqxmd.com/read/28223001/rethinking-ckd-evaluation-should-we-be-quantifying-basal-or-stimulated-gfr-to-maximize-precision-and-sensitivity
#1
Bruce A Molitoris
Chronic kidney disease (CKD) is an increasing clinical problem. Although clinical risk factors and biomarkers for the development and progression of CKD have been identified, there is no commercial surveillance technology to definitively diagnose and quantify the severity and progressive loss of glomerular filtration rate (GFR) in CKD. This has limited the study of potential therapies to late stages of CKD when FDA-registerable events are more likely. Because patient outcomes, including the rate of CKD progression, correlate with disease severity and effective therapy may require early intervention, being able to diagnose and stratify patients by their level of decreased kidney function early on is key for translational progress...
February 17, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28214834/kidney-injury-molecule-1-is-elevated-in-nephropathy-and-mediates-macrophage-activation-via-the-mapk-signalling-pathway
#2
Lei Tian, Xinghua Shao, Yuanyuan Xie, Qin Wang, Xiajing Che, Minfang Zhang, Weijia Xu, Yao Xu, Shan Mou, Zhaohui Ni
BACKGROUND/AIMS: Kidney injury molecule-1 (KIM-1) is highly expressed in renal tubular cells after injury and is usually regarded as an early biomarker of acute kidney injury(AKI). The aim of this study was to determine the role of KIM-1 in the development of renal tubular injury Methods: Clinical samples, three different animal models and in vitro experiments were utilized to determine the possible mechanism underlying the involvement of KIM-1 in kidney injury. RESULTS: Both plasma and urinary KIM-1 expression levels were significantly higher in AKI and chronic kidney disease (CKD) patients than in healthy volunteers, and urinary KIM-1 expression was significantly higher in CKD patients than in AKI patients...
February 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28213568/estimated-glomerular-filtration-rate-and-albuminuria-are-associated-with-biomarkers-of-cardiac-injury-in-a-population-based-cohort-study-the-maastricht-study
#3
Remy J H Martens, Dorien M Kimenai, Jeroen P Kooman, Coen D A Stehouwer, Frans E S Tan, Otto Bekers, Pieter C Dagnelie, Carla J H van der Kallen, Abraham A Kroon, Karel M L Leunissen, Frank M van der Sande, Nicolaas C Schaper, Simone J S Sep, Miranda T Schram, Jeroen D van Suijlen, Marja P van Dieijen-Visser, Steven J R Meex, Ronald M A Henry
BACKGROUND: Chronic kidney disease (CKD) is associated with an increased cardiovascular disease mortality risk. It is, however, less clear at what point in the course from normal kidney function to CKD the association with cardiovascular disease appears. Studying the associations of estimated glomerular filtration rate (eGFR) and albuminuria with biomarkers of (subclinical) cardiac injury in a population without substantial CKD may clarify this issue. METHODS: We examined the cross-sectional associations of eGFR and urinary albumin excretion (UAE) with high-sensitivity cardiac troponin (hs-cTn) T, hs-cTnI, and N-terminal probrain natriuretic-peptide (NT-proBNP) in 3103 individuals from a population-based diabetes-enriched cohort study...
February 17, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28192277/cdkn2a-p16ink4-a-expression-is-associated-with-vascular-progeria-in-chronic-kidney-disease
#4
Peter Stenvinkel, Karin Luttropp, Dagmara McGuinness, Anna Witasp, Abdul Rashid Qureshi, Annika Wernerson, Louise Nordfors, Martin Schalling, Jonaz Ripsweden, Lars Wennberg, Magnus Söderberg, Peter Bárány, Hannes Olauson, Paul G Shiels
Patients with chronic kidney disease (CKD) display a progeric vascular phenotype linked to apoptosis, cellular senescence and osteogenic transformation. This has proven intractable to modelling appropriately in model organisms. We have therefore investigated this directly in man, using for the first time validated cellular biomarkers of ageing (CDKN2A/p16(INK4a), SA-β-Gal) in arterial biopsies from 61 CKD patients undergoing living donor renal transplantation. We demonstrate that in the uremic milieu, increased arterial expression of CDKN2A/p16(INK4a) associated with vascular progeria in CKD, independently of chronological age...
February 9, 2017: Aging
https://www.readbyqxmd.com/read/28191531/urine-biomarkers-in-renal-allograft
#5
Hongting Wang, Zuan-Tao Lin, Yulin Yuan, Tianfu Wu
There is a high risk for the survival of patients with an end-stage renal disease for kidney transplantation. To avoid rejection by strict medication adherence is of utmost importance to avoid the failure of a kidney transplant. It is imperative to develop non-invasive biomarkers to assess immunity risk, and to ultimately provide guidance for therapeutic decision-making following kidney transplantation. Urine biomarkers may represent the promising non-invasive tools that will help in predicting risk or success rates of kidney transplantations...
September 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28190493/utility-of-urinary-alkaline-phosphatase-and-%C3%AE-glutamyl-transpeptidase-in-diagnosing-acute-kidney-injury-in-dogs
#6
Ran Nivy, Yochai Avital, Itamar Aroch, Gilad Segev
The diagnostic utility of urinary alkaline phosphatase (uALP) and γ-glutamyl transpeptidase (uGGT) activities in naturally occurring acute kidney injury (AKI) was investigated in a heterogeneous group of dogs. The study included client-owned dogs with AKI (n = 32), chronic kidney disease (CKD, n = 13), lower urinary tract infection (LUTI, n = 15) and healthy controls (n = 24). uGGT and uALP activities were normalised to urinary creatinine (uCr) concentrations (uGGT/uCr and uALP/uCr, respectively)...
February 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28183314/dpp-4-inhibition-has-no-acute-effect-on-bnp-and-its-n-terminal-pro-hormone-measured-by-commercial-immune-assays-a-randomized-cross-over-trial-in-patients-with-type-2-diabetes
#7
Gian Paolo Fadini, Benedetta Maria Bonora, Mattia Albiero, Martina Zaninotto, Mario Plebani, Angelo Avogaro
BACKGROUND: Use of dipeptidyl peptidase-4 inhibitors (DPP4-i) for the treatment of type 2 diabetes (T2D) has been associated with a possible increase in the risk for heart failure (HF). B-type natriuretic peptide (BNP), which is both a biomarker of HF and a hemodynamically active hormone, is a substrate of DPP-4. We herein tested the acute effects of the DPP-4i linagliptin on BNP and NT-proBNP in a cross-over placebo-controlled trial in patients with T2D with and without chronic kidney disease (CKD)...
February 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28181420/hypoxia-inducible-factor-1-a-urinary-biomarker-of-kidney-disease
#8
S Movafagh, D Raj, M Sanaei-Ardekani, D Bhatia, K Vo, M Mahmoudieh, R Rahman, E H Kim, A F Harralson
Identifying noninvasive biomarkers of kidney disease is valuable for diagnostic and therapeutic purposes. Hypoxia inducible factor 1 (HIF-1) expression is known to be elevated in the kidneys in several renal disease pathologies. We hypothesized that the urinary HIF-1a mRNA level may be a suitable biomarker for expression of this protein in chronic kidney disease (CKD). We compared HIF-1a mRNA levels from urine pellets of CKD and healthy subjects. To ensure that urinary HIF-1a mRNA is of kidney origin, we examined colocalization of HIF-1a mRNA with two kidney specific markers in urine cells...
February 9, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28164555/continuous-hemodiafiltration-with-an-an69st-hemofilter-an69st-chdf-as-fgf-23-lowering-therapy
#9
Masafumi Yamato, Yusuke Minematsu, Yuta Ikemiya, Junichi Shibata, Junya Fujii, Takumi Minato, Sachie Miyagawa, Kaori Takaori, Yoko Tomiyama, Ikue Nagayama, Akira Wada, Takahito Ito, Hirotsugu Iwatani
BACKGROUND: Recent studies have shown that fibroblast growth factor-23 (FGF-23) is elevated not only in chronic kidney disease (CKD), but also in acute illnesses such as acute kidney injury, septic shock, and acute heart failure. FGF-23 would be not only a simple biomarker but also a direct toxic factor in acute illness. Therefore, lowering circulating FGF-23 levels in clinical practice would be an exciting and valuable interventional strategy. Continuous hemodiafiltration (CHDF) is often performed for the treatment of the aforementioned acute illnesses...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28161315/renal-development-in-the-fetus-and-premature-infant
#10
REVIEW
Stacy Rosenblum, Abhijeet Pal, Kimberly Reidy
Congenital abnormalities of the kidney and urinary tract (CAKUT) are one of the leading congenital defects to be identified on prenatal ultrasound. CAKUT represent a broad spectrum of abnormalities, from transient hydronephrosis to severe bilateral renal agenesis. CAKUT are a major contributor to chronic and end stage kidney disease (CKD/ESKD) in children. Prenatal imaging is useful to identify CAKUT, but will not detect all defects. Both genetic abnormalities and the fetal environment contribute to CAKUT. Monogenic gene mutations identified in human CAKUT have advanced our understanding of molecular mechanisms of renal development...
February 1, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28160524/urinary-f2-isoprostanes-in-cats-with-international-renal-interest-society-stage-1-4-chronic-kidney-disease
#11
W Whitehouse, J Quimby, S Wan, K Monaghan, R Robbins, L A Trepanier
BACKGROUND: F2 -isoprostanes, a biomarker of oxidant injury, increase with advancing chronic kidney disease (CKD) in humans. In cats, the relationship between CKD and oxidative stress is poorly understood. OBJECTIVES: To determine whether cats with advancing CKD have increasing urinary F2 -isoprostanes. ANIMALS: Control cats without evidence of CKD (≥6 years old; n = 11), and cats with IRIS stage 1 (n = 8), 2 (n = 38), 3 (n = 21), and 4 (n = 10) CKD...
February 4, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28152049/differentially-expressed-mir-3680-5p-is-associated-with-parathyroid-hormone-regulation-in-peritoneal-dialysis-patients
#12
Sohyun Jeong, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim
Mineral and bone disorder (MBD) is observed universally in patients with chronic kidney disease (CKD). Detrimental MBD-related skeletal changes include increased prevalence of fracture, cardiovascular disease, and mortality. MicroRNAs (miRNAs) have been identified as useful biomarkers in various diseases, and the aim of this study was to identify miRNAs associated with parathyroid hormone level in peritoneal dialysis (PD) patients. Fifty-two PD patients were enrolled and grouped by their intact parathyroid hormone (iPTH) level; 11 patients had low iPTH (<150 pg/mL) and 41 patients had high iPTH (≥150 pg/mL)...
2017: PloS One
https://www.readbyqxmd.com/read/28148896/investigated-the-safety-of-intra-renal-arterial-transfusion-of-autologous-cd34-cells-and-time-courses-of-creatinine-levels-endothelial-dysfunction-biomarkers-and-micro-rnas-in-chronic-kidney-disease-patients-phase-i-clinical-trial
#13
Mel S Lee, Fan-Yen Lee, Yung-Lung Chen, Pei-Hsun Sung, Hsin-Ju Chiang, Kuan-Hung Chen, Tien-Hung Huang, Yi-Ling Chen, John Y Chiang, Tsung-Cheng Yin, Hsueh-Wen Chang, Hon-Kan Yip
This was a phase I clinical trial to investigate the safety of autologous peripheral-blood-derived CD34+ cell therapy for patients with chronic kidney disease (CKD-treatment) (i.e., at Stages III and IV). Between November 2014 and October 2015, a total of 10 study patients were prospectively enrolled into this phase I trial. Patients who failed to enroll into the trial in the initial state of eligibility assessment were served as CKD-control group (n = 9). The health-control group was composed of 10 volunteers for the purposes of comparing (1) circulation level of endothelial progenitor cells (EPCs), (2) angiogenesis ability, and (3) anti-apoptotic miRNAs between healthy subjects and CKD patients...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28147348/the-association-between-biomarker-profiles-etiology-of-chronic-kidney-disease-and-mortality
#14
David Langsford, Mila Tang, Hicham I Cheikh Hassan, Ognjenka Djurdjev, Manish M Sood, Adeera Levin
BACKGROUND: Prognosis in chronic kidney disease (CKD) for adverse outcomes differs substantially based on the etiology of CKD. We examined whether the biomarker profile differed based on CKD etiology and whether they were associated with mortality. METHODS: Prospective observational study of 1,157 patients, 663 with diabetic kidney disease (DKD), 273 with glomerulonephritis (GN), and 221 with cystic/interstitial disease (polycystic kidney disease, pyelonephritis or chronic tubulointerstitial nephritis [PCK/TIN]) were identified in the Canadian Study of Prediction of Dialysis, Death and Interim Cardiovascular events over Time cohort...
February 2, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28145489/improving-the-diagnostic-accuracy-of-acute-myocardial-infarction-with-the-use-of-high-sensitive-cardiac-troponin-t-in-different-chronic-kidney-disease-stages
#15
Hongliu Yang, Jing Liu, Han Luo, Xiaoxi Zeng, Xi Tang, Liang Ma, Hongxia Mai, Shenju Gou, Fang Liu, Ping Fu
High-sensitive cardiac troponin T (hs-TnT) is a critical biomarker in diagnosis of acute myocardial infarction (AMI). However, CKD individuals usually have elevated hs-TnT even in the absence of AMI. Our study aimed to explore the optimal cutoff-value of hs-TnT and further to improve diagnostic accuracy of AMI in CKD patients. Clinical data of 489 patients were collected from the maintained database between September 2010 and June 2014. CKD patients with AMI were assigned to CKD+AMI group and CKD patients without AMI were assigned to CKD group...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28134398/-new-biomarkers-of-ckd-mbd
#16
Marzia Pasquali, Lida Tartaglione, Silverio Rotondi
Chronic kidney failure involves abnormalities of mineral metabolism, skeletal and of cardiovascular system (so called CKD - MBD) that have a major impact on the survival of renal patient. Increasingly complex pathophysiological mechanisms have been discovered in recent years with evidence of new molecules involved in the development of CKD - MBD. Besides the classical PTH / Vitamin D axis, the most recent discovery of a new FGF23 / Klotho axis has expanded knowledge on the mechanisms of mineral homeostasis but also on the more complex mechanisms of cellular aging, vascular calcification and cardiac remodeling...
November 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28128223/neutrophil-gelatinase-associated-lipocalin-ngal-fails-as-an-early-predictor-of-contrast-induced-nephropathy-in-chronic-kidney-disease-anti-ci-aki-study
#17
Werner Ribitsch, Gernot Schilcher, Franz Quehenberger, Stefan Pilz, Rupert H Portugaller, Martini Truschnig-Wilders, Robert Zweiker, Marianne Brodmann, Philipp Stiegler, Alexander R Rosenkranz, John W Pickering, Joerg H Horina
: The aim of the study was to evaluate the diagnostic accuracy of urinary neutrophil gelatinase- associated lipocalin (uNGAL) in patients with chronic kidney disease (CKD) as an early biomarker for contrast induced acute kidney injury (CI-AKI) and to investigate whether patients with an uNGAL increase might benefit from an additional intravenous volume expansion with regard to CI-AKI-incidence. We performed a prospective randomized controlled trial in 617 CKD-patients undergoing intra-arterial angiography...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28120157/subclinical-markers-of-cardiovascular-disease-predict-adverse-outcomes-in-chronic-kidney-disease-patients-with-normal-left-ventricular-ejection-fraction
#18
Samir Sulemane, Vasileios F Panoulas, Athanasios Bratsas, Julia Grapsa, Edwina A Brown, Petros Nihoyannopoulos
Emerging cardiovascular biomarkers, such as speckle tracking echocardiography (STE) and aortic pulse wave velocity (aPWV), have recently demonstrated the presence of subclinical left ventricular dysfunction and arterial stiffening in patients with chronic kidney disease (CKD) and no previous cardiovascular history. However, limited information exists on the prognostic impact of these biomarkers. We aimed to investigate whether STE and aPWV predict major adverse cardiac events (MACE) in this patient population...
January 24, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28118643/the-association-of-baseline-and-longitudinal-change-in-endothelial-microparticle-count-with-mortality-in-chronic-kidney-disease
#19
Darren Green, Sarah Skeoch, M Yvonne Alexander, Philip A Kalra, Ben Parker
BACKGROUND: Chronic kidney disease (CKD) is associated with a unique milieu of vascular pathology, and effective biomarkers of active vascular damage are lacking. A candidate biomarker is the quantification of circulating endothelial microparticles (EMPs). This study observed baseline and longitudinal EMP change (δEMP) and established the association of these with all-cause mortality and cardiovascular events in CKD. METHOD: An observational study in adults with CKD (estimated glomerular filtration rate [eGFR] <60 mL/min/1...
January 25, 2017: Nephron
https://www.readbyqxmd.com/read/28115282/potential-application-of-klotho-in-human-chronic-kidney-disease
#20
REVIEW
Javier A Neyra, Ming Chang Hu
The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble Klotho in the circulation starts to decline early in chronic kidney disease (CKD) stage 2 and urinary Klotho possibly even earlier in CKD stage 1. Therefore soluble Klotho could serve as an early and sensitive marker of kidney function decline. Moreover, preclinical animal data support Klotho deficiency is not just merely a biomarker, but a pathogenic factor for CKD progression and extrarenal CKD complications including cardiovascular disease and disturbed mineral metabolism...
January 20, 2017: Bone
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