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https://www.readbyqxmd.com/read/29050355/dual-time-point-18-f-fdg-pet-ct-imaging-with-multiple-metabolic-parameters-in-the-differential-diagnosis-of-malignancy-suspected-bone-joint-lesions
#1
Chen-Tian Shen, Zhong-Ling Qiu, Zhen-Kui Sun, Wei-Jun Wei, Hong-Jun Song, Xin-Yun Zhang, Quan-Yong Luo
The purpose of this study was to evaluate the diagnostic potential of dual time-point(18)F-FDG PET/CT imaging with multiple metabolic parameters in malignancy-suspected bone/joint lesions. Fifty seven consecutive patients were recruited. PET parameters including SUVmax, SUVmean, metabolic tumor volume (MTV), total lesional glycolysis (TLG) and retention indexes (RIs) were obtained. Thirty five malignant and 22 benign lesions were confirmed by pathology. In all, 48 receiver operating characteristic (ROC) curves were derived...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050239/application-of-in-vivo-imaging-techniques-to-monitor-therapeutic-efficiency-of-plx4720-in-an-experimental-model-of-microsatellite-instable-colorectal-cancer
#2
Sarah Rohde, Tobias Lindner, Stefan Polei, Jan Stenzel, Luise Borufka, Sophie Achilles, Eric Hartmann, Falko Lange, Claudia Maletzki, Michael Linnebacher, Änne Glass, Sarah Marie Schwarzenböck, Jens Kurth, Alexander Hohn, Brigitte Vollmar, Bernd Joachim Krause, Robert Jaster
OBJECTIVES: Patient-derived tumor cell lines are a powerful tool to analyze the sensitivity of individual tumors to specific therapies in mice. An essential prerequisite for such an approach are reliable quantitative techniques to monitor tumor progression in vivo. METHODS: We have employed HROC24 cells, grown heterotopically in NMRI Foxn1(nu) mice, as a model of microsatellite instable colorectal cancer to investigate the therapeutic efficiencies of 5'-fluorouracil (5'-FU) and the mutant BRAF inhibitor PLX4720, a vemurafenib analogue, by three independent methods: external measurement by caliper, magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-((18)F)fluoro-D-glucose ((18)F-FDG)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050119/-feasibility-of-domestic-18-f-dopa-pet-ct-scanning-in-the-differential-diagnosis-of-pancreatic-lesions-in-children-with-hyperinsulinemic-hypoglycemia
#3
M Y Zhang, J J Ge, Z Pei, K R Dong, L Chen, X Wang, Z W Zhang, X J Li, L Xi, R Q Cheng, G P Lu, Y H Guan, F H Luo
Objective: To study the feasibility of (18)F-fluoro-L-dihydroxyphenylalanine positron emission tomography/Computed tomography ((18)F-DOPA PET/CT) scanning in the localization and differential diagnosing of focal versus diffuse form of pancreas lesions in patients with hyperinsulinemic hypoglycemia (HH). Method: Twenty-four patients were diagnosed with HH between January, 2016 and February, 2017 in the Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University using an integrated clinical and biochemical diagnostic protocol, domestic (18)F-DOPA PET/CT imaging technique were applied after MRI and ultrasound failed to detect pancreas lesions...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29049252/prognostic-role-of-fdg-pet-ct-in-patients-with-differentiated-thyroid-cancer-treated-with-131-iodine-empiric-therapy
#4
Barbara Salvatore, Michele Klain, Emanuele Nicolai, Domenico D'Amico, Gianluca De Matteis, Marco Raddi, Rosa Fonti, Teresa Pellegrino, Giovanni Storto, Alberto Cuocolo, Leonardo Pace
BACKGROUND: To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg). METHODS: Forty-nine patients with histological diagnosis of DTC (31 with papillary and 18 with follicular carcinoma) follow-up for a mean period of 7.9 ± 5 years after empiric RAI therapy were retrospectively analyzed...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049175/retrospective-analysis-for-the-false-positive-diagnosis-of-pet-ct-scan-in-lung-cancer-patients
#5
Mingxia Feng, Xuemei Yang, Qiang Ma, Yong He
Early diagnosis is pivotal for prognosis of lung cancer patients. Positron emission tomography/computed tomography (PET-CT) is a useful method for human cancer diagnosis. In this study, we aimed to explore the false positive diagnosis of PET-CT in lung cancerIn total, 754 patients diagnosed with lung cancer via PET-CT were retrospectively collected in this study. Histopathological detection served as gold standard. The diagnostic accuracy of PET-CT was defined as the proportion of lung cancer cases confirmed by pathological diagnosis in the study subjects, and the percentages of misdiagnosed cases represented the false positive diagnosis of PET-CT...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049172/primary-cardiac-angiosarcoma-a-case-report
#6
Ruiping Zhang, Lu Li, Xinming Li, Yanlin Chu, Jihua Wu, Yunge Gao
BACKGROUND: Primary cardiac angiosarcoma is rare, but it is the most aggressive type of cardiac malignant tumor. When disease is confirmed it is often late in its stage resulting in a poor prognosis. CASE PRESENTATION: We reported a 52-year-old woman who complained of dyspnea for 2 months and dry cough for 10 days. Computed tomography (CT), F-fluorodeoxyglucose (F-FDG), positron emission tomography-computed tomography (PET-CT), and transthoracic echocardiography showed a space-occupying lesion 7 cm × 5 cm × 5 cm in the right atrium...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049095/a-clinical-evaluation-of-the-impact-of-the-bayesian-penalized-likelihood-reconstruction-algorithm-on-pet-fdg-metrics
#7
Delphine Vallot, Olivier Caselles, Leonor Chaltiel, Anthony Fernandez, Erwan Gabiache, Lawrence Dierickx, Slimane Zerdoud, Mathilde Bauriaud, Frédéric Courbon
PURPOSE: The aim of this study was to evaluate the impact of using the Bayesian penalized likelihood (BPL) algorithm on a bismuth germanium oxide positron emission tomography (PET)/computed tomography (CT) system for F-FDG PET/CT exams in case of low injected activity and scan duration. MATERIALS AND METHODS: F-FDG respiratory gated PET/CT performed on 102 cancer patients, injected with ∼2 MBq/kg of F-FDG, were reconstructed using two algorithms: ordered subset expectation maximization (OSEM) and BPL...
October 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29046974/stress-echocardiography-in-stable-coronary-artery-disease
#8
REVIEW
Sothinathan Gurunathan, Roxy Senior
PURPOSE OF REVIEW: Stress echocardiography (SE) is a well-established technique for the diagnosis and risk stratification of patients with known or suspected coronary artery disease (CAD). This review article summarizes the status of SE in CAD, including testing protocols, clinical efficacy and current use of newer technologies: myocardial perfusion, strain imaging, three-dimensional echocardiography and adjunctive carotid ultrasonography. RECENT FINDINGS: Recent major findings in SE include the clinical value of myocardial perfusion imaging in multicentre studies, as well as when added to left ventricular (LV) wall motion assessment in clinical service...
October 18, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/29046927/fdg-pet-ct-radiomics-for-predicting-the-outcome-of-locally-advanced-rectal-cancer
#9
Pierre Lovinfosse, Marc Polus, Daniel Van Daele, Philippe Martinive, Frédéric Daenen, Mathieu Hatt, Dimitris Visvikis, Benjamin Koopmansch, Frédéric Lambert, Carla Coimbra, Laurence Seidel, Adelin Albert, Philippe Delvenne, Roland Hustinx
PURPOSE: The aim of this study was to investigate the prognostic value of baseline (18)F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC underwent (18)F-FDG PET/CT before treatment. Maximum and mean standard uptake values (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), histogram-intensity features, as well as 11 local and regional textural features, were evaluated...
October 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29046281/free-fatty-acid-flux-measured-using-1-11-c-palmitate-positron-emission-tomography-and-u-13-c-palmitate-in-humans
#10
Qiaojan Han, Yanli Cao, Nicola W Gathaiya, Bradley J Kemp, Michael D Jensen
PET radiopharmaceuticals can non-invasively measure free fatty acid (FFA) tissue uptake. Investigators often use PET scan-derived data to calculate FFA flux. We tested whether the [1-(11)C]palmitate PET measures of palmitate flux provide results equivalent to a continuous infusion of [U-(13)C]palmitate. Nine volunteers participated in study 1 to evaluate whether a rapidly (10-20 seconds) given bolus of [1-(11)C]palmitate affects calculated flux results. Thirty volunteers participated in study 2, which was identical to study 1 except that the [1-(11)C]palmitate bolus was given over 1 minute...
October 18, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29045338/a-clinical-evaluation-of-the-impact-of-the-bayesian-penalized-likelihood-reconstruction-algorithm-on-pet-fdg-metrics
#11
Delphine Vallot, Olivier Caselles, Leonor Chaltiel, Anthony Fernandez, Erwan Gabiache, Lawrence Dierickx, Slimane Zerdoud, Mathilde Bauriaud, Frédéric Courbon
PURPOSE: The aim of this study was to evaluate the impact of using the Bayesian penalized likelihood (BPL) algorithm on a bismuth germanium oxide positron emission tomography (PET)/computed tomography (CT) system for F-FDG PET/CT exams in case of low injected activity and scan duration. MATERIALS AND METHODS: F-FDG respiratory gated PET/CT performed on 102 cancer patients, injected with ∼2 MBq/kg of F-FDG, were reconstructed using two algorithms: ordered subset expectation maximization (OSEM) and BPL...
November 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29045188/rapid-evolution-of-thyroid-dysfunction-in-patients-treated-with-nivolumab
#12
Grenye O'Malley, Hanna J Lee, Samir Parekh, Matthew D Galsky, Cardinale B Smith, Philip Friedlander, Robert T Yanagisawa, Emily J Gallagher
OBJECTIVE: To describe the evolution of thyroid dysfunction in a series of patients with cancer treated with the immune checkpoint inhibitor anti-programmed cell death protein-1 (PD-1) monoclonal antibody, nivolumab. METHODS: Cases of thyroid dysfunction after initiation of checkpoint inhibitor treatment were identified from the Division of Endocrinology clinical practice at Mount Sinai Hospital, New York from April 2016 to February 2017. Charts were reviewed to identify patients treated with nivolumab with new onset of thyroid dysfunction...
October 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#13
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29044297/psa-levels-psa-doubling-time-gleason-score-and-prior-therapy-cannot-predict-measured-uptake-of-68-ga-psma-hbed-cc-lesion-uptake-in-recurrent-metastatic-prostate-cancer
#14
Frederik A Verburg, David Pfister, Natascha I Drude, Felix M Mottaghy, Florian Behrendt
AIM: To assess whether clinical prostate cancer (PCA) related factors and therapy status can predict the degree of tracer uptake on [(68)Ga]PSMA-HBED-CC PET/CT. MATERIALS & METHODS: We retrospectively studied 124 patients with recurrent an/or metastatic PCA who underwent [(68)Ga]PSMA-HBED-CC PET/CT. The maximum standardized uptake value (SUVmax) was determined in the prostate bed as well as in three size categories (≤ 5 mm, > 5-15 mm, > 15 mm) in pelvic lymph node, extrapelvic lymph node, bone and visceral metastases...
October 18, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/29043862/the-potential-role-of-fdg-pet-ct-in-the-characterization-of-the-activity-of-crohn-s-disease-staging-follow-up-and-prognosis-estimation-a-pilot-study
#15
Károly Palatka, Sándor Kacska, Szilvia Lovas, Ildikó Garai, József Varga, László Galuska
OBJECTIVES: FDG PET-CT is a global, noninvasive, sensitive method to determine the location and activity of inflammatory lesions. Segmental FDG uptake is proportional with immune cell infiltration of bowel. Our aim was to evaluate prospectively the role of PET in patients with active Crohn's disease (CD) before and after one year's biological therapy, and to compare simple endoscopic score for CD (SES-CD), CD activity index (CDAI) and global PET scores. We also analyzed the prognostic value of initial PET scores...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29043431/-99m-tc-hdp-bone-scintigraphy-and-18-f-sodiumfluoride-pet-ct-in-primary-staging-of-patients-with-prostate-cancer
#16
Maurits Wondergem, Friso M van der Zant, Remco J J Knol, Anne Marij G Burgers, Siebe D Bos, Igle J de Jong, Jan Pruim
INTRODUCTION/AIM: Correct staging of patients with prostate cancer is important for treatment planning and prognosis. Although bone scintigraphy with (99m)Tc-phosphonates (BS) is generally advised for staging by guidelines in high risk prostate cancer, this imaging technique is hampered by a high rate of inconclusive results and moderate accuracy. Potentially better imaging techniques for detection of bone metastases such as (18)F-sodiumfluoride PET/CT (NaF PET/CT) are therefore being evaluated...
October 17, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29043208/phosphaturic-mesenchymal-tumor-pmt-exceptionally-rare-disease-yet-crucial-not-to-miss
#17
Amir Ghorbani-Aghbolaghi, Morgan Angus Darrow, Tao Wang
Phosphaturic mesenchymal tumors (PMTs) are very rare tumors which are frequently associated with Tumor Induced Osteomalacia (TIO), a paraneoplastic syndrome that manifests as renal phosphate wasting. The tumor cells produce a peptide hormone-like substance known as fibroblast growth factor 23 (FGF23), a physiologic regulator of phosphate levels. FGF23 decreases proximal tubule reabsorption of phosphates and inhibits 1-α-hydroxylase, which reduces levels of 1-α, 25-dihydroxyvitamine D3. Thus, overexpression of FGF23 by the tumor cells leads to increased excretion of phosphate in the urine, mobilization of calcium and phosphate from bones, and the reduction of osteoblastic activity, ultimately resulting in widespread osteomalacia...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29042975/comparison-of-dwibs-t2-image-fusion-and-pet-ct-for-the-diagnosis-of-cancer-in-the-abdominal-cavity
#18
Minoru Tomizawa, Fuminobu Shinozaki, Yoshitaka Uchida, Katsuhiro Uchiyama, Satomi Tanaka, Takafumi Sunaoshi, Daisuke Kano, Eriko Sugiyama, Misaki Shite, Ryouta Haga, Yoshiya Fukamizu, Toshiyuki Fujita, Satoshi Kagayama, Rumiko Hasegawa, Yoshinori Shirai, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Fusion images of diffusion-weighted whole-body imaging with background body signal suppression and T2-weighted image (DWIBS/T2) demonstrate a strong signal for malignancies, with a high contrast against the surrounding tissues, and enable anatomical analysis. In the present study, DWIBS/T2 was compared with (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for diagnosing cancer in the abdomen. Patient records, including imaging results of examination conducted between November 2012 and May 2014, were analyzed retrospectively...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042474/development-of-a-pet-ct-and-pet-mri-patient-information-films-in-collaboration-with-patient-representatives-previously-treated-for-cancer
#19
Robert Shortman, John Hoath, Tina Osadolor, Pierpaolo Inge, Louise Roper, Jamshed Bomanji, Ashley M Groves
Introduction: PET/MRI and PET CT scanning carries an increased psychological burden for patients which may be improved by effective preparation prior to attendance for the procedure. We aimed to devise an online resource for patient benefit prior to PET/MRI and PET/CT scanning. Methods: With the help of patient representatives' the style and content for two patient information films was reviewed at each stage of the process to explain the patient journey. Results: Two patient information films were produced for patients undergoing PET scanning, Positive feedback from healthcare providers and users was obtained...
October 17, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29042471/measuring-patient-perception-of-quality-in-a-radiology-department-by-adapting-a-standardized-industry-proven-tool
#20
Farouk Dako, Rick Wray, Omer Awan, Rathan M Subramaniam
Introduction: Our study quantitatively measures patient perception of quality and satisfaction in a PET-CT center at the point of care using a psychometrically validated questionnaire, SERVPERF, to guide subsequent quality improvement interventions. SERVPERF is a survey instrument that captures service quality by measuring performance of various services. It has demonstrated reliability and validity across various industries including healthcare, banking, transportation, telecommunication and higher education...
October 17, 2017: Journal of Nuclear Medicine Technology
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