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https://www.readbyqxmd.com/read/29933508/recent-advances-on-the-development-of-phantoms-using-3d-printing-for-imaging-with-ct-mri-pet-spect-and-ultrasound
#1
REVIEW
Valeria Filippou, Charalampos Tsoumpas
PURPOSE: Printing technology, capable of producing three-dimensional (3D) objects, has evolved in recent years and provides potential for developing reproducible and sophisticated physical phantoms. 3D printing technology can help rapidly develop relatively low cost phantoms with appropriate complexities, which are useful in imaging or dosimetry measurements. The need for more realistic phantoms is emerging since imaging systems are now capable of acquiring multimodal and multiparametric data...
June 22, 2018: Medical Physics
https://www.readbyqxmd.com/read/29933484/-modern-management-of-pancoast-tumour
#2
Alessandro Marra
Pancoast or superior pulmonary sulcus tumour is a subset of lung carcinoma that invades the structures of the thoracic inlet - first ribs, distal roots of the brachial plexus, stellate ganglion, vertebrae, and subclavian vessels. The first symptom is usually shoulder pain; consequently, most patients are initially treated for osteoarthritis. Late diagnosis is common. Success of therapy depends on an accurate staging: standard imaging with CT scan of the chest, PET-CT scan, brain MRI are needed to rule out distant metastases, endobronchial ultrasound-guided needle biopsy (EBUS-TBNA) or mediastinoscopy are mandatory for reliable nodal staging...
June 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29933047/pharmacologic-inhibition-of-akt-leads-to-cell-death-in-relapsed-multiple-myeloma
#3
In-Sung Song, Yu Jeong Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Nam-Chul Ha, MyungGeun Shin, Kyung Soo Ko, Byoung Doo Rhee, Sungbo Shim, Sung-Wuk Jang, Jin Han
Multiple myeloma (MM) is a neoplastic plasma cell disorder with high disease recurrence rates. Novel therapeutic approaches capable of improving outcomes in patients with MM are urgently required. The AKT signalling plays a critical regulatory role in MM pathophysiology, including survival, proliferation, metabolism, and has emerged as a key therapeutic target. Here, we identified a novel AKT inhibitor, HS1793, and defined its mechanism of action and clinical significance in MM. HS1793 disrupted the interaction between AKT and heat shock protein 90, resulting in protein phosphatase 2A-modulated phosphorylated-AKT (p-AKT) reduction...
June 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29932307/surgically-resected-t1-and-t2-stage-esophageal-squamous-cell-carcinoma-t-and-n-staging-performance-of-eus-and-pet-ct
#4
Dong Young Jeong, Min Yeong Kim, Kyung Soo Lee, Joon Young Choi, Soo Jeong Kim, Myung Jin Chung, Yang Won Min, Hong Kwan Kim, Jae Ill Zo, Young Mog Shim, Jong-Mu Sun
This study aimed to evaluate the frequency of nodal metastases and to disclose the diagnostic performance of endoscopic ultrasonography (EUS) and PET/CT in T and N staging in surgically resected early-stage esophageal squamous cell carcinomas (eSCCs). Institutional review board approved this retrospective study with waiver of informed consent for reviewing medical record. We included 435 patients with an early T-stage (Tis or T1a [≤T1a], T1b and T2) eSCC. The rates of metastatic lymphadenopathy were calculated...
June 22, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29931417/correlation-of-benign-incidental-findings-seen-on-whole-body-pet-ct-with-knee-mri-patterns-of-18-f-fdg-avidity-intra-articular-pathology-and-bone-marrow-edema-lesions
#5
Christopher J Burke, William R Walter, Sushma Gaddam, Hien Pham, James S Babb, Joseph Sanger, Fabio Ponzo
OBJECTIVES: To correlate patterns of 18 F-FDG uptake on whole-body PET-CT with MR findings and compare the degree of FDG activity between symptomatic and asymptomatic knees. MATERIALS AND METHODS: Retrospective database query was performed using codes for knee MRI as well as whole-body PET-CT. Patients with malignant disease involving the knee or hardware were excluded. Patients who had both studies performed within 1 year between 2012 and 2017 were included for analysis...
June 21, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29930731/response-to-single-low-dose-177-lu-dota-eb-tate-treatment-in-patients-with-advanced-neuroendocrine-neoplasm-a-prospective-pilot-study
#6
Hao Wang, Yuejuan Cheng, Jingjing Zhang, Jie Zang, Hui Li, Qingxing Liu, Jingnan Wang, Orit Jacobson, Fang Li, Zhaohui Zhu, Xiaoyuan Chen
Objective: 177 Lu-DOTA-EB-TATE is a theranostic agent based on octreotate that uses an Evans blue structure to bind albumin to improve the pharmacokinetics and pharmacodynamics. This pilot study aims to evaluate the efficacy of a single low-dose treatment using 177 Lu-DOTA-EB-TATE in patients with advanced neuroendocrine neoplasm (NEN). Methods: With IRB approval and informed consent, 4 NEN patients were enrolled to undergo 177 Lu-DOTA-EB-TATE treatment with a single low dose of 0.66 ± 0.06 GBq (17.8 ± 1...
2018: Theranostics
https://www.readbyqxmd.com/read/29930720/-18-f-fdg-pet-ct-characteristics-of-pulmonary-sclerosing-hemangioma-vs-pulmonary-hamartoma
#7
Lei Jiang, Yan Huang, Qiying Tang, Qingping Zhao, Yuan Li, Xiaodong Wu, Huoqiang Wang
The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in PSH versus pulmonary hamartoma. 18 F-FDG PET/CT characteristic findings of 12 patients with PSH and 14 patients with pulmonary hamartoma were retrospectively reviewed. A total of 12 lesions were detected from the 12 patients with PSH, of which 3 masses exhibited calcification...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29930505/using-ct-data-to-improve-the-quantitative-analysis-of-18-f-fbb-pet-neuroimages
#8
Fermín Segovia, Raquel Sánchez-Vañó, Juan M Górriz, Javier Ramírez, Pablo Sopena-Novales, Nathalie Testart Dardel, Antonio Rodríguez-Fernández, Manuel Gómez-Río
18 F-FBB PET is a neuroimaging modality that is been increasingly used to assess brain amyloid deposits in potential patients with Alzheimer's disease (AD). In this work, we analyze the usefulness of these data to distinguish between AD and non-AD patients. A dataset with 18 F-FBB PET brain images from 94 subjects diagnosed with AD and other disorders was evaluated by means of multiple analyses based on t -test, ANOVA, Fisher Discriminant Analysis and Support Vector Machine (SVM) classification. In addition, we propose to calculate amyloid standardized uptake values (SUVs) using only gray-matter voxels, which can be estimated using Computed Tomography (CT) images...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29930154/caserta-e-chea-j-minnix-m-et-al-copper-64-labeled-daratumumab-as-a-pet-ct-imaging-tracer-for-multiple-myeloma-blood-2018-131-7-741-745
#9
(no author information available yet)
No abstract text is available yet for this article.
June 21, 2018: Blood
https://www.readbyqxmd.com/read/29928439/ovarian-cancer-initially-presenting-with-supra-clavicular-lymph-node-metastasis-a-case-report
#10
Lu Hong, Hui Qiu, Zijie Mei, Hui Zhang, Shaopin Liu, Hong Cao
Supra-clavicular lymph node metastasis from ovarian cancer is rare. The present study reports the unique case of a 43-years-old patient who initially presented with left supra-clavicular lymph node metastasis, and was nulliparous. According to fine-needle aspiration cytology of the metastatic left supra-clavicular lymph nodes and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) scan, the patient was diagnosed with poorly differentiated serous carcinoma of ovarian cancer, stage IV...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29927635/comparative-effectiveness-of-18f-fdg-pet-ct-and-contrast-enhanced-ct-in-the-diagnosis-of-suspected-large-vessel-vasculitis
#11
Sriram Vaidyanathan, Arpita Chattopadhyay, Sarah L Mackie, Andrew Scarsbrook
OBJECTIVES: Large-vessel vasculitis (LVV) is a serious illness with potentially life-threatening consequences. 18 F-FDG PET-CT has emerged as a valuable diagnostic tool in suspected LVV, combining the strengths of functional and structural imaging. This study aimed to compare the accuracy of FDG PET-CT and contrast-enhanced CT (CECT) in the evaluation of patients with LVV. METHODS: A retrospective database review for LVV patients undergoing CECT and PET-CT between 2011 to 2016 yielded demographics, scan interval and vasculitis type...
June 21, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29926557/clinical-characteristics-of-false-positive-lymph-node-on-chest-ct-or-pet-ct-confirmed-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-lung-cancer
#12
Jongmin Lee, Young Kyoon Kim, Ye Young Seo, Eun Kyoung Choi, Dong Soo Lee, Yeon Sil Kim, Sook Hee Hong, Jin Hyoung Kang, Kyo Young Lee, Jae Kil Park, Sook Whan Sung, Hyun Bin Kim, Mi Sun Park, Hyeon Woo Yim, Seung Joon Kim
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard procedure to evaluate suspicious lymph node involvement of lung cancer because computed tomography (CT) and ¹⁸F-fluorodeoxyglucose positron emission tomography-CT (PET-CT) have limitations in their sensitivity and specificity. There are a number of benign causes of false positive lymph node such as anthracosis or anthracofibrosis, pneumoconiosis, old or active tuberculosis, interstitial lung disease, and other infectious conditions including pneumonia...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29926343/publisher-correction-to-18-f-fdg-pet-ct-metabolic-tumor-parameters-and-radiomics-features-in-aggressive-non-hodgkin-s-lymphoma-as-predictors-of-treatment-outcome-and-survival
#13
Aatif Parvez, Noam Tau, Douglas Hussey, Manjula Maganti, Ur Metser
In the original publication of the article, the title was incorrectly.
June 20, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29926115/-18-f-fdg-pet-ct-and-mri-features-of-myxoid-liposarcomas-and-intramuscular-myxomas
#14
Brendan W Lunn, Laurel A Littrell, Doris E Wenger, Stephen M Broski
OBJECTIVE: To examine the imaging characteristics of intramuscular myxomas (IM) and myxoid liposarcomas (MLS) on 18 F-FDG PET/CT and MRI. MATERIALS AND METHODS: With IRB approval, our institutional imaging database was searched for pathologically proven IM and MLS evaluated by 18 F-FDG PET/CT and MRI. PET/CT and MRI imaging characteristics were recorded and correlated with pathologic diagnosis. RESULTS: We found eight patients (2 M, 6 F) with IM (mean age 65...
June 20, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29926007/diagnostic-performance-of-11c-choline-pet-ct-and-fdg-pet-ct-in-prostate-cancer
#15
Kazuhiro Kitajima, Shingo Yamamoto, Soichi Odawara, Kaoru Kobayashi, Masayuki Fujiwara, Norihiko Kamikonya, Kazuhito Fukushima, Yukako Nakanishi, Takahiko Hashimoto, Yusuke Yamada, Toru Suzuki, Akihiro Kanematsu, Michio Nojima, Koichiro Yamakado
We compared 11C-choline and FDG PET/CT scan findings for the staging and restaging of prostate cancer. Twenty Japanese prostate cancer patients underwent 11C-choline and FDG PET/CT before (n=5) or after (n=15) treatment. Using a five-point scale, we compared these scanning modalities regarding patient- and lesion-based diagnostic performance for local recurrence, untreated primary tumor, and lymph node and bony metastases. Of the 20 patients, documented local lesions, and node and bony metastases were present in 11 (55...
June 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29925750/-differentiation-between-hepatic-focal-lesions-and-heterogenous-physiological-accumulations-by-early-delayed-scanning-in-18-f-fdg-pet-ct-examination
#16
Ayaka Ushio, Komei Takauchi, Makoto Kobayashi, Nobukazu Abe, Hiroomi Sumida, Yasushi Nagata, Kazuo Awai
PURPOSE: We examined whether early delayed scanning is useful for differentiation of liver lesion and heterogenous physiological accumulation in positron emission tomography (PET) examination. METHODS: The subjects of the study were 33 patients with colorectal cancer who underwent PET examination and were added early delayed scanning to distinguish between liver lesions and heterogenous physiological accumulation to conventional early images. We placed same regions of interest (ROI) in the tumor and hepatic parenchyma for early delayed and conventional early images...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29925151/-analysis-of-relationship-between-18-f-fdg-pet-ct-suvmax-of-esophageal-squamous-cell-carcinoma-before-treatment-and-postoperative-survival
#17
L Dai, H Fu, F Wang, R Guo, Y B Yang, Y Lin, K N Chen
Objective: To evaluate the value of (18)F-FDG PET/CT in predicting long-term survival of esophageal squamous cell carcinoma(ESCC) before initial treatment. Methods: A total of 167 ESCC patients were retrospectively analyzed who underwent surgery between January 2010 and December 2014 in prospective database of Peking University Cancer Hospital Thoracic Surgery Department One, all cases were included according to inclusion and exclusion criteria.The relationship between SUVmax of the primary tumor and patients' age, gender, tumor location, tumor differentiation, tumor regression grade as well as long term survival were compared...
June 5, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29924717/case-259
#18
Decai Tian, Xiaodong Zhu, Rong Xue, Peng Zhao, Yuanrong Yao
History In November 2012, a previously healthy 31-year-old woman was admitted to our hospital with a 2-month history of right-sided numbness, diplopia, and intermittent nausea and dizziness. She did not have a history of fever, weight loss, headache, photophobia, seizure, or extremity weakness. Physical examination revealed left abduction limitation and right-sided hypoesthesia. Kernig and Brudzinski signs were absent, and pathergy test results were negative. Laboratory evaluation revealed normal complete and differential blood counts, normal serum chemistry, and normal immune function...
July 2018: Radiology
https://www.readbyqxmd.com/read/29924023/small-cell-lung-cancer-mimicking-lymphoma-in-ct-and-68ga-dota-noc-pet-ct-a-case-report
#19
Liyan Lu, Fengfang Li, Yamei Zhang, Peng Wang, Xindao Yin, Wenbin Li
RATIONALE: Small cell lung cancer accounts for 15-20% of all lung cancers and is the most common pulmonary neuroendocrine neoplasm. Most small cell lung cancers arise from lobar or main bronchi, the most common manifestations of small cell lung cancer is a large mass centrally located within the lung parenchyma or a mediastinal mass involving the hilus. Small cell lung cancer is easily ignored by clinicians without lung parenchyma and hilus involvement. Here, we report a case of small cell lung cancer, which was misdiagnosed as the lymphoma in contrast enhanced CT and Ga-DOTA-NOC PET/CT imagings...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923561/n-1-4-tri-4-alkoxy-2-hydroxybenzyl-daza-efficient-one-pot-synthesis-and-labelling-with-68-ga-for-pet-liver-imaging-in-ovo
#20
Julia Greiser, Christian Kühnel, Helmar Görls, Wolfgang Weigand, Martin Freesmeyer
We report the isolation of a new type of 1,4-diazepan-6-amine (DAZA)-based ligand. Condensation of aldehydes with DAZA gives a novel class of 1,5-diazabicyclo[3.2.1]octanes in nearly quantitative yields. Subsequent reductive cleavage of these bicyclic aminal species with sodium borohydride selectively leads to N,1,4-tri(4-alkoxy-2-hydroxybenzyl)-1,4-diazepan-6-amines (alkoxy = Me: TMeOHB-DAZA; alkoxy = Et: TEtOHB-DAZA) via a unique reductive alkylation reaction in which a substituent is added to the DAZA moiety without the presence of an alkylating agent...
June 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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