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https://www.readbyqxmd.com/read/29453702/the-relationship-between-local-recurrences-and-distant-metastases-in-prostate-cancer-can-11-c-choline-pet-ct-contribute-to-understand-the-link
#1
Giampiero Giovacchini, Andrea Ciarmiello, Elisabetta Giovannini, Andrei Fodor, Cesare Cozzarini, Paola Mapelli, Elena Incerti, Nadia Di Muzio, Luigi Gianolli, Maria Picchio
PURPOSE: Previous studies in prostate cancer (PCa) patients tried to correlate the onset of local recurrence (LR) with the development of distant metastases and formulated, based on theoretical and experimental data, hypotheses linking the two events. We aimed to address this issue with 11 C-choline positron emission tomography/computed tomography (PET/CT). METHODS: This retrospective study included 491 PCa patients previously treated with radical prostatectomy who had undergone 11 C-choline PET/CT owing to biochemical failure...
February 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29453681/-18-f-fpybf-2-a-new-f-18-labelled-amyloid-imaging-pet-tracer-biodistribution-and-radiation-dosimetry-assessment-of-first-in-man-18-f-fpybf-2-pet-imaging
#2
Ryuichi Nishii, Tatsuya Higashi, Shinya Kagawa, Chio Okuyama, Yoshihiko Kishibe, Masaaki Takahashi, Tomoko Okina, Norio Suzuki, Hiroshi Hasegawa, Yasuhiro Nagahama, Koichi Ishizu, Naoya Oishi, Hiroyuki Kimura, Hiroyuki Watanabe, Masahiro Ono, Hideo Saji, Hiroshi Yamauchi
OBJECTIVE: Recently, a benzofuran derivative for the imaging of β-amyloid plaques, 5-(5-(2-(2-(2- 18 F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)- N-methylpyridin-2-amine ( 18 F-FPYBF-2) has been validated as a tracer for amyloid imaging and it was found that 18 F-FPYBF-2 PET/CT is a useful and reliable diagnostic tool for the evaluation of AD (Higashi et al. Ann Nucl Med, https://doi.org/10.1007/s12149-018-1236-1 , 2018). The aim of this study was to assess the biodistribution and radiation dosimetry of diagnostic dosages of 18 F-FPYBF-2 in normal healthy volunteers as a first-in-man study...
February 16, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29453680/prognostic-implications-of-62-cu-diacetyl-bis-n-4-methylthiosemicarbazone-pet-ct-in-patients-with-glioma
#3
Akira Toriihara, Makoto Ohtake, Kensuke Tateishi, Ayako Hino-Shishikura, Tomohiro Yoneyama, Yoshio Kitazume, Tomio Inoue, Nobutaka Kawahara, Ukihide Tateishi
OBJECTIVE: The potential of positron emission tomography/computed tomography using 62 Cu-diacetyl-bis (N 4 -methylthiosemicarbazone) ( 62 Cu-ATSM PET/CT), which was originally developed as a hypoxic tracer, to predict therapeutic resistance and prognosis has been reported in various cancers. Our purpose was to investigate prognostic value of 62 Cu-ATSM PET/CT in patients with glioma, compared to PET/CT using 2-deoxy-2-[ 18 F]fluoro-D-glucose ( 18 F-FDG). METHOD: 56 patients with glioma of World Health Organization grade 2-4 were enrolled...
February 16, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29453603/repeatable-and-reproducible-measurements-of-myocardial-oxidative-metabolism-blood-flow-and-external-efficiency-using-11-c-acetate-pet
#4
Kai Yi Wu, Vincent Dinculescu, Jennifer M Renaud, Shin-Yee Chen, Ian G Burwash, Lisa M Mielniczuk, Rob S B Beanlands, Robert A deKemp
BACKGROUND: Non-invasive approaches to investigate myocardial efficiency can help track the progression of heart failure (HF). This study evaluates the repeatability and reproducibility of 11 C-acetate positron emission tomography (PET) imaging of oxidative metabolism. METHODS AND RESULTS: Dynamic 11 C-acetate PET scans were performed at baseline and followup (47 ± 22 days apart) in 20 patients with stable HF with reduced ejection fraction. Two observers blinded to patients' clinical data used FlowQuant ® to evaluate test-retest repeatability, as well as intra- and inter-observer reproducibility of 11 C-acetate tracer uptake and clearance rates, for the measurement of myocardial oxygen consumption (MVO 2 ), myocardial external efficiency (MEE), work metabolic index (WMI), and myocardial blood flow...
February 16, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29453385/prediction-of-advanced-axillary-lymph-node-metastases-ypn2-3-using-breast-mr-imaging-and-pet-ct-after-neoadjuvant-chemotherapy-in-invasive-ductal-carcinoma-patients
#5
Won Hwa Kim, Sang-Woo Lee, Hye Jung Kim, Yee Soo Chae, Shin Young Jeong, Jin Hyang Jung, Ho Yong Park, Won Kee Lee
We aimed to investigate the value of breast magnetic resonance (MR) imaging and positron emission tomography-computed tomography (PET/CT) in predicting advanced axillary lymph node (ALN) metastases (ypN2-3) after neoadjuvant chemotherapy (NAC) in invasive ductal carcinoma patients. A total of 108 patients with invasive ductal carcinoma underwent breast MR imaging and PET/CT both before and after NAC (termed initial staging and restaging, respectively). The number of positive ALNs and the short diameter (SD) of the largest ALN on breast MR imaging and maximal standardized uptake value (SUVmax) in the ALNs on PET/CT were evaluated...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453165/endoscopic-submucosal-dissection-for-the-diagnosis-and-therapy-of-pedunculated-gastric-cancer-with-prolapse-into-the-duodenal-bulb-a-case-report
#6
Norihiko Suzuki, Masashi Yoshida, Hironori Ohdaira, Tomonori Imakita, Nobuhiro Tsutsui, Yasunobu Kobayashi, Junji Takahashi, Shinya Okada, Masaki Kitajima, Yutaka Suzuki
INTRODUCTION: Preoperative diagnosis of gastric cancer invasion is not always sufficiently accurate. Diagnostic endoscopic submucosal dissection (ESD) can be performed for the purpose of accurate decision making and to avoid partial treatment vs aggressive over-treatment. We present a patient with the gastric cancer with indeterminate pre-operative diagnosis for depth of the invasion. CASE PRESENTATION: A 70-year-old man presented at our hospital because both anti-Helicobacter pylori (Hp) IGG antibody and serum pepsinogen (PG) levels were classified as positive...
February 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29452619/monitoring-response-to-therapy
#7
REVIEW
Mike M Sathekge, Alfred O Ankrah, Ismaheel Lawal, Mariza Vorster
Monitoring response to treatment is a key element in the management of infectious diseases, yet controversies still persist on reliable biomarkers for noninvasive response evaluation. Considering the limitations of invasiveness of most diagnostic procedures and the issue of expression heterogeneity of pathology, molecular imaging is better able to assay in vivo biologic processes noninvasively and quantitatively. The usefulness of 18 F-FDG-PET/CT in assessing treatment response in infectious diseases is more promising than for conventional imaging...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452618/radionuclide-imaging-of-infection-and-inflammation-in-children-a-review
#8
REVIEW
Marguerite T Parisi, Jeffrey P Otjen, A Luana Stanescu, Barry L Shulkin
With the exception of radiolabeled monoclonal antibodies, antibody fragments and radiolabeled peptides which have seen little application in the pediatric population, the nuclear medicine imaging procedures used in the evaluation of infection and inflammation are the same for both adults and children. These procedures include (1) either a two- or a three-phase bone scan using technetium-99m methylene diphosphonate; (2) Gallium 67-citrate; (3) in vitro radiolabeled white blood cell imaging (using 111 Indium-oxine or 99m Technetium hexamethyl-propylene-amine-oxime-labeled white blood cells); and (4) hybrid imaging with 18 F-FDG...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452616/tuberculosis
#9
REVIEW
Alfred O Ankrah, Andor W J M Glaudemans, Alex Maes, Christophe Van de Wiele, Rudi A J O Dierckx, Mariza Vorster, Mike M Sathekge
Tuberculosis (TB) is currently the world's leading cause of infectious mortality. Imaging plays an important role in the management of this disease. The complex immune response of the human body to Mycobacterium tuberculosis results in a wide array of clinical manifestations, making clinical and radiological diagnosis challenging. 18 F-FDG-PET/CT is very sensitive in the early detection of TB in most parts of the body; however, the lack of specificity is a major limitation. 18 F-FDG-PET/CT images the whole body and provides a pre-therapeutic metabolic map of the infection, enabling clinicians to accurately assess the burden of disease...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452615/fever-of-unknown-origin-the-value-of-fdg-pet-ct
#10
REVIEW
Ilse J E Kouijzer, Catharina M Mulders-Manders, Chantal P Bleeker-Rovers, Wim J G Oyen
Fever of unknown origin (FUO) is commonly defined as fever higher than 38.3°C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory investigations. The differential diagnosis of FUO can be subdivided in four categories: infections, malignancies, noninfectious inflammatory diseases, and miscellaneous causes. In most cases of FUO, there is an uncommon presentation of a common disease. FDG-PET/CT is a sensitive diagnostic technique for the evaluation of FUO by facilitating anatomical localization of focally increased FDG uptake, thereby guiding further diagnostic tests to achieve a final diagnosis...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29450854/imaging-of-the-scrotum-beyond-sonography
#11
REVIEW
Gian Carlo Parenti, Francesco Feletti, Aldo Carnevale, Licia Uccelli, Melchiore Giganti
The aim of this article is to describe the role of second-level imaging techniques after an initial ultrasonography evaluation in the assessment of scrotal diseases. While ultrasonography remains central as the primary imaging modality for the evaluation of pathologic conditions of the scrotum, the role of magnetic resonance imaging continues to evolve: it can actually be valuable as a problem-solving tool when sonographic findings are equivocal or inconclusive. Magnetic resonance imaging of the scrotum may provide accurate detection and characterization of scrotal diseases, well depicting the precise location of scrotal masses (intratesticular or extratesticular) and reliably characterizing benign conditions simulating neoplastic processes, thus preventing unnecessary radical surgery...
February 15, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29450259/hand-assisted-laparoscopic-partial-nephrectomy-for-large-renal-carcinoma-with-succinate-dehydrogenase-deficiency
#12
Ann Buhl Bersang, Sarah Bube, Mikkel Fode, Nessn H Azawi
Background: Germline mutations in succinate dehydrogenase (SDH) are associated with multifocal cancers: pituitary gland tumors, pheochromocytomas, paragangliomas, gastrointestinal stromal tumors, and renal-cell carcinomas (RCCs). SDH-deficient renal-cell carcinoma (SDH-RCC) was first identified in 2004 as an inherited kidney cancer with mutations in the SDH gene. SDH consists of A, B, C, and D units. Mutation in the SDHB gene is the most common mutation in SDH-deficient RCCs. Case Presentation: We report a case of a 51-year-old healthy man diagnosed with SDHB germline mutation and RCCs...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29449935/pleomorphic-liposarcoma-of-bone-a-rare-primary-malignant-bone-tumour
#13
G L Tiemeier, J M Brown, S E Pratap, C McCarthy, A Kastrenopoulou, K Bradley, S Wilson, Z Orosz, C L M H Gibbons, U Oppermann, N A Athanasou
Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29449446/improving-accuracy-of-simultaneously-reconstructed-activity-and-attenuation-maps-using-deep-learning
#14
Donghwi Hwang, Kyeong Yun Kim, Seung Kwan Kang, Seongho Seo, Jin Chul Paeng, Dong Soo Lee, Jae Sung Lee
Simultaneous reconstruction of activity and attenuation using the maximum likelihood reconstruction of activity and attenuation (MLAA) augmented by time-of-flight (TOF) information is a promising method for positron emission tomography (PET) attenuation correction. However, it still suffers from several problems, including crosstalk artifacts, slow convergence speed, and noisy attenuation maps (μ-maps). In this work, we developed deep convolutional neural networks (CNNs) to overcome these MLAA limitations, and we verified their feasibility using a clinical brain PET data set...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29449445/evaluation-of-penalized-likelihood-estimation-reconstruction-on-a-digital-time-of-flight-pet-ct-scanner-for-18-f-fdg-whole-body-examinations
#15
Elin Lindström, Anders Sundin, Carlos Trampal, Lars Lindsjö, Ezgi Ilan, Torsten Danfors, Gunnar Antoni, Jens Sörensen, Mark Lubberink
Resolution and quantitative accuracy of positron emission tomography (PET) are highly influenced by the reconstruction method. Penalized likelihood estimation algorithms allow for fully convergent iterative reconstruction, generating a higher image contrast while limiting noise compared to ordered subsets expectation maximization (OSEM). In this study, block-sequential regularized expectation maximization (BSREM) was compared to time-of-flight OSEM (TOF-OSEM). Various strengths of noise penalization factor β were tested along with scan durations and transaxial field of views (FOVs) with the aim to evaluate the performance and clinical use of BSREM for 18 F-FDG-PET-computed tomography (CT), both in quantitative terms and in a qualitative visual evaluation...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29448120/imaging-features-of-malignant-abdominal-neuroendocrine-tumors-with-rare-presentation
#16
Giuseppe Corrias, Serena Monti, Natally Horvat, Laura Tang, Olca Basturk, Luca Saba, Lorenzo Mannelli
BACKGROUND: Gastroenteropancreatic neuroendocrine tumors (NETs) are rare entities arising from neuroendocrine cells in the gastroenteric tract and pancreas. The purpose of this article is to present four cases of gastroenteropancreatic NETs that featured a challenging diagnosis. CASE PRESENTATION: We report a case series of four NETs, each with different features. All NETs were suspected based on clinical and biochemical data. The workup of the abnormalities was performed with CT, PET or MRI...
February 8, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29447210/functional-imaging-of-the-interaction-between-gut-microbiota-and-the-human-host-a-proof-of-concept-clinical-study-evaluating-novel-use-for-18f-fdg-pet-ct
#17
Ben Boursi, Thomas J Werner, Saeid Gholami, Sina Houshmand, Ronac Mamtani, James D Lewis, Gary D Wu, Abass Alavi, Yu-Xiao Yang
Recent data comparing germ-free to conventionally-raised mice demonstrated that energy homeostasis of colonocytes is dependent on gut microbiota through regulation of short chain fatty acids (SCFA) production and glucose utilization. We sought to evaluate 18F-FDG PET-CT as a novel technique for functional imaging of alterations in glucose metabolism as a result of the interaction between the gut microbiota and the human host. We conducted a prospective study in healthy humans that underwent 18F-FDG PET-CT and sampling of the gut microbiota before and after orally administered broad-spectrum antibiotics...
2018: PloS One
https://www.readbyqxmd.com/read/29447047/prospective-comparative-study-of-18-f-sodium-fluoride-pet-ct-and-planar-bone-scintigraphy-for-treatment-response-assessment-of-bone-metastases-in-patients-with-prostate-cancer
#18
Randi Fuglsang Fonager, Helle Damgaard Zacho, Niels Christian Langkilde, Joan Fledelius, June Anita Ejlersen, Helle Westergreen Hendel, Christian Haarmark, Mette Moe, Jesper Carl Mortensen, Mads Ryø Jochumsen, Lars Jelstrup Petersen
AIM: To compare 18 F-sodium fluoride positron emission tomography/computed tomography (NaF PET/CT) and 99m Tc-labelled diphosphonate bone scan (BS) for the monitoring of bone metastases in patients with prostate cancer undergoing anti-cancer treatment. MATERIAL AND METHODS: Data from 64 patients with prostate cancer were included. The patients received androgen-deprivation therapy (ADT), next-generation hormonal therapy (NGH) or chemotherapy. The patients had a baseline scan and 1-3 subsequent scans during six months of treatment...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29446832/an-assessment-of-18-f-fdg-pet-ct-for-thoracic-screening-and-risk-stratification-of-pulmonary-nodules-in-multiple-endocrine-neoplasia-type-1
#19
Alvin So, Owen Pointon, Richard Hodgson, John Burgess
CONTEXT: Bronchopulmonary neuroendocrine tumours (bpNETs) and thymic carcinoid (ThC) are features of Multiple Endocrine Neoplasia Type 1 (MEN 1) and surveillance guidelines recommend periodic thoracic imaging. The optimal thoracic imaging modality and screening frequency remains uncertain as does the prognosis of small lung nodules when identified. OBJECTIVES: To evaluate fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) for identification and prognostic assessment of thoracic lesions in MEN 1...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29445878/feasibility-of-intraoperative-detection-of-sentinel-lymph-nodes-with-89-zirconium-labelled-nanocolloidal-albumin-pet-ct-and-a-handheld-high-energy-gamma-probe
#20
Derrek A Heuveling, K Hakki Karagozoglu, Arthur Van Lingen, Otto S Hoekstra, Guus A M S Van Dongen, Remco De Bree
BACKGROUND: PET/CT lymphoscintigraphy using 89 Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary tumour. This study aims to demonstrate the feasibility of PET/CT lymphoscintigraphy followed by intraoperative detection of 89 Zr-nanocolloidal albumin containing SLNs with the use of a handheld high-energy gamma probe. METHODS: PET/CT lymphoscintigraphy was performed after peritumoural injection of 89 Zr-nanocolloidal albumin in five patients with oral cavity carcinoma planned for surgical resection...
February 14, 2018: EJNMMI Research
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