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Spreading depression

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https://www.readbyqxmd.com/read/28214183/-misuse-and-dependence-on-prescription-opioids-prevention-identification-and-treatment
#1
B Rolland, D Bouhassira, N Authier, M Auriacombe, V Martinez, P Polomeni, G Brousse, R Schwan, P Lack, J Bachellier, S Rostaing, P Bendimerad, P Vergne-Salle, M Dematteis, S Perrot
Since the 1990s, the use of prescription opioids has largely spread, which has brought a real progress in the treatment of pain. The long-term use of prescription opioid is sometimes required, and may lead to pharmacological tolerance and withdrawal symptoms, i.e. pharmacological dependence on prescription opioids. Occasionally, this may also lead to misuse of prescription opioids (MPO). MPO preferentially occurs in vulnerable individuals, i.e., those with a young age, history of other addictive or psychiatric disorders, especially anxious and depressive disorders...
February 14, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28202321/anxiety-and-depression-among-sexual-minority-women-and-men-in-sweden-is-the-risk-equally-spread-within-the-sexual-minority-population
#2
Charlotte Björkenstam, Emma Björkenstam, Gunnar Andersson, Susan Cochran, Kyriaki Kosidou
INTRODUCTION: Sexual minority individuals have a higher risk of anxiety and depression compared with heterosexuals. However, whether the higher risk is spread equally across the sexual minority population is not clear. AIM: To investigate the association between sexual orientation and self-reported current anxiety and a history of diagnosis of depression, paying particular attention to possible subgroup differences in risks within the sexual minority population, stratified by sex and to examine participants' history of medical care for anxiety disorders and depression...
February 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28193695/cortical-spreading-depression-closes-the-paravascular-space-and-impairs-glymphatic-flow-implications-for-migraine-headache
#3
Aaron J Schain, Agustin Melo, Andrew M Strassman, Rami Burstein
Functioning of the glymphatic system, a network of paravascular tunnels through which cortical interstitial solutes are cleared from the brain, has recently been linked to sleep and traumatic brain injury, both of which can affect the progression of migraine. This led us to investigate the connection between migraine and the glymphatic system. Taking advantage of a novel in vivo method we developed to visualize the PVS in naïve uninjected mice using 2-photon microscopy, we show that a single wave of cortical spreading depression (CSD), an animal model of migraine aura, induces a rapid and nearly complete closure of the paravascular space (PVS) around surface as well as penetrating cortical arteries and veins lasting several minutes, and gradually recovering over 30 min...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28181217/hypercoagulability-and-migraine
#4
Gretchen E Tietjen, Stuart A Collins
BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated estrogen levels, endothelial activation and dysfunction, antiphospholipid antibodies (aPL), deficiency of coagulation inhibitors, and presence of certain genetic polymorphisms...
February 9, 2017: Headache
https://www.readbyqxmd.com/read/28159907/acid-sensing-ion-channels-activated-by-evoked-released-protons-modulate-synaptic-transmission-at-the-mouse-calyx-of-held-synapse
#5
Carlota González-Inchauspe, Francisco J Urbano, Mariano N Di Guilmi, Osvaldo D Uchitel
: Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be activated in neurons of the medial nucleus of the trapezoid body (MNTB) of the auditory system in the CNS. A drop in extracellular pH induces transient inward currents (IASIC) in postsynaptic MNTB neurons from wild type (WT) mice. The inhibition of IASIC by psalmotoxin-1 (PcTx1) and the absence of these currents in knock out mice for ASIC-1a subunit (ASIC1a(-/-)) suggest that homomeric ASIC-1a channels are mediating these currents in MNTB neurons...
February 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28158158/prevention-of-post-herpetic-neuralgia-from-dream-to-reality-a-ten-step-model
#6
Mohamed Younis Makharita
Herpes zoster (HZ) is a painful, blistering skin eruption in a dermatomal distribution caused by reactivation of a latent varicella zoster virus in the dorsal root ganglia (DRG). Post-herpetic neuralgia (PHN) is the most common complication of acute herpes zoster (AHZ).Severe prodrome, greater acute pain and dermatomal injury, and the density of the eruption are the risk factors and predictors for developing PHN. PHN has a substantial effect on the quality of life; many patients develop severe physical, occupational, social, and psychosocial disabilities as a result of the unceasing pain...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28155572/exploring-the-role-of-microglia-in-cortical-spreading-depression-in-neurological-disease
#7
Mamoru Shibata, Norihiro Suzuki
Microglia play a pivotal role in innate immunity in the brain. During development, they mature from myeloerythroid progenitor cells in the yolk sac and colonize the brain to establish a resident population of tissue macrophages. In the postnatal brain, they exert phagocytosis and induce inflammatory response against invading pathogens. Microglia also act as guardians of brain homeostasis by surveying the microenvironment using motile processes. Cortical spreading depression (CSD) is a slowly propagating (2-5 mm/min) wave of rapid, near-complete depolarization of neurons and astrocytes followed by a period of electrical suppression of a distinct population of cortical neurons...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28145727/estrogen-dependent-effects-of-5-hydroxytryptophan-on-cortical-spreading-depression-in-rat-modelling-the-serotonin-ovarian-hormone-interaction-in-migraine-aura
#8
Virginie Chauvel, Sylvie Multon, Jean Schoenen
Background Cortical spreading depression (CSD) is the likely culprit of the migraine aura. Migraine is sexually dimorphic and thought to be a "low 5-HT" condition. We sought to decipher the interrelation between serotonin, ovarian hormones and cortical excitability in a model of migraine aura. Methods Occipital KCl-induced CSDs were recorded for one hour at parieto-occipital and frontal levels in adult male (n = 16) and female rats (n = 64) one hour after intraperitoneal (i.p.) injection of 5-hydroxytryptophan (5-HTP) or NaCl...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28127585/cortical-spreading-depression-promotes-persistent-mechanical-sensitization-of-intracranial-meningeal-afferents-implications-for-the-intracranial-mechanosensitivity-of-migraine
#9
Jun Zhao, Dan Levy
Migraine is one of the most common and disabling diseases in the world. A major feature of migraine headache is its aggravation by maneuvers that momentarily increase intracranial pressure. A key hypothesis implicates mechanical sensitization of trigeminal afferents that innervate the intracranial meninges in mediating this feature of migraine. However, whether such pain-related neural response actually develops under endogenous conditions that are linked specifically to migraine remains to be established. Single-unit recordings in the trigeminal ganglion of anesthetized male rats were combined with quantitative mechanical stimulation of the cranial dura mater to determine whether cortical spreading depression (CSD), an endogenous migraine-triggering event, affects the mechanosensitivity of meningeal afferents...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28123433/cortical-spreading-depression-induced-preconditioning-in-the-brain
#10
REVIEW
Ping-Ping Shen, Shuai Hou, Di Ma, Ming-Ming Zhao, Ming-Qin Zhu, Jing-Dian Zhang, Liang-Shu Feng, Li Cui, Jia-Chun Feng
Cortical spreading depression is a technique used to depolarize neurons. During focal or global ischemia, cortical spreading depression-induced preconditioning can enhance tolerance of further injury. However, the underlying mechanism for this phenomenon remains relatively unclear. To date, numerous issues exist regarding the experimental model used to precondition the brain with cortical spreading depression, such as the administration route, concentration of potassium chloride, induction time, duration of the protection provided by the treatment, the regional distribution of the protective effect, and the types of neurons responsible for the greater tolerance...
November 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28088802/interplay-between-cortical-spreading-depolarization-and-seizures
#11
Daniel R Kramer, Tatsuhiro Fujii, Ifije Ohiorhenuan, Charles Y Liu
Cortical spreading depolarization (CSD) is an electrophysiologic phenomenon found mostly in the setting of neurologic injury resulting in the disturbance of ion homeostasis and leading to changes in the local vascular response. The bioelectric etiology of CSD shares similarities to those in epileptic disorders, yet the relationship between seizures and CSD is unclear, with several studies observing cortical depression before, during, and after seizure activity, thus obscuring our understanding of whether CSD activity potentiates or limits seizures and vice versa...
January 14, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28075480/costs-of-selfing-prevent-the-spread-of-a-self-compatibility-mutation-that-causes-reproductive-assurance
#12
Nathan C Layman, M Thilina R Fernando, Christopher R Herlihy, Jeremiah W Busch
In flowering plants, shifts from outcrossing to partial or complete self-fertilization have occurred independently thousands of times, yet the underlying adaptive processes are difficult to discern. Selfing's ability to provide reproductive assurance when pollination is uncertain is an oft-cited ecological explanation for its evolution, but this benefit may be outweighed by genetic costs diminishing its selective advantage over outcrossing. We directly studied the fitness effects of a self-compatibility (SC) mutation that was backcrossed into a self-incompatible (SI) population of Leavenworthia alabamica, illuminating the direction and magnitude of selection on the mating-system modifier...
January 11, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28057556/brain-mitochondrial-calcium-transport-origins-of-the-set-point-concept-and-its-application-to-physiology-and-pathology
#13
David G Nicholls
The transport of calcium across the inner mitochondrial membrane plays a key role in neuronal physiology and pathology. The kinetic responses of the uniporter and efflux pathways are such that a cytosolic free calcium 'set-point' can be established - above which there is net calcium accumulation into the matrix that is reversed when plasma membrane transport lowers cytosolic calcium. Pathological activation of N-methyl-d-aspartate receptor mediated sodium and calcium entry into the neuron, as occurs in stroke and spreading depression, places severe demands on both the ATP-generating and calcium loading capacities of the neuronal mitochondria as the set-point is exceeded...
January 2, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28053504/nitroglycerin-enhances-the-propagation-of-cortical-spreading-depression-comparative-studies-with-sumatriptan-and-novel-kynurenic-acid-analogues
#14
Levente Knapp, Bence Szita, Kitti Kocsis, László Vécsei, József Toldi
BACKGROUND: The complex pathophysiology of migraine is not yet clearly understood; therefore, experimental models are essential for the investigation of the processes related to migraine headache, which include cortical spreading depression (CSD) and NO donor-induced neurovascular changes. Data on the assessment of drug efficacy in these models are often limited, which prompted us to investigate a novel combined migraine model in which an effective pharmacon could be more easily identified...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28049513/neural-hyperactivity-in-the-amygdala-induced-by-chronic-treatment-of-rats-with-analgesics-may-elucidate-the-mechanisms-underlying-psychiatric-comorbidities-associated-with-medication-overuse-headache
#15
Aree Wanasuntronwong, Ukkrit Jansri, Anan Srikiatkhachorn
BACKGROUND: Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are unclear, but the amygdala is likely to be involved in their pathogenesis. To investigate the mechanisms underlying the comorbidities we used elevated plus maze and open field tests to assess anxiety-like behavior in rats chronically treated with analgesics. We measured the electrical properties of neurons in the amygdala, and examined the cortical spreading depression (CSD)-evoked expression of Fos in the trigeminal nucleus caudalis (TNC) and amygdala of rats chronically treated with analgesics...
January 3, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28030474/therapeutic-benefits-of-the-methyl-donor-s-adenosylmethionine-sam-on-nerve-injury-induced-mechanical-hypersensitivity-and-cognitive-impairment-in-mice
#16
Stéphanie Grégoire, Magali Millecamps, Lina Naso, Sonia Do Carmo, A Claudio Cuello, Moshe Szyf, Laura S Stone
Despite considerable advances in understanding mechanisms involved in chronic pain, effective treatment remains elusive. Co-morbid conditions including anxiety, depression and cognitive impairment further impact quality of life. Chronic pain is associated with reversible changes in brain anatomy and function and with long-term changes in gene expression. Epigenetic mechanisms, including DNA methylation, contribute to wide-spread and long-lasting reprogramming of gene expression. We previously reported decreases in global DNA methylation in the mouse frontal cortex six months following induction of neuropathic pain using the Spared Nerve Injury (SNI) model...
December 22, 2016: Pain
https://www.readbyqxmd.com/read/28028801/transcranial-magnetic-stimulation-basic-principles-and-clinical-applications-in-migraine
#17
Anthony T Barker, Kevin Shields
PURPOSE: Transcranial magnetic stimulation (TMS) is a neurophysiological technique with a long established pedigree of safety, tolerability, and efficacy. Initially TMS was used to study the function of the cerebral cortex, but it has now become a treatment for migraine, one of the most common and debilitating neurological conditions. In this review we discuss the scientific background and development of the technique. We explore its application for the treatment of migraine and ponder the possible mechanisms of action in this most common neurological condition...
December 28, 2016: Headache
https://www.readbyqxmd.com/read/28011644/phosphatidylserine-stimulates-ceramide-1-phosphate-c1p-intermembrane-transfer-by-c1p-transfer-proteins
#18
Xiuhong Zhai, Yong-Guang Gao, Shrawan K Mishra, Dhirendra K Simanshu, Ivan A Boldyrev, Linda M Benson, H Robert Bergen, Lucy Malinina, John Mundy, Julian G Molotkovsky, Dinshaw J Patel, Rhoderick E Brown
Genetic models for studying localized cell suicide that halt the spread of pathogen infection and immune response activation in plants include Arabidopsis accelerated-cell-death11 (acd11) In this mutant, sphingolipid homeostasis is disrupted via depletion of ACD11, a lipid transfer protein that is specific for ceramide-1-phosphate (C1P) and phyto-C1P. The C1P binding site in ACD11 and in human ceramide-1-phosphate transfer protein (CPTP) is surrounded by cationic residues. Here, we investigated the functional regulation of ACD11 and CPTP by anionic phosphoglycerides and found that 1 palmitoyl-2-oleoyl-phosphatidic acid or 1-palmitoyl-2-oleoyl-phosphatidylglycerol (≈ 15 mol%) in C1P-source vesicles depressed C1P intermembrane transfer...
December 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28003755/neuroprotection-and-acidosis-induced-by-cortical-spreading-depression
#19
COMMENT
Kenneth K Kwong, Suk-Tak Chan
No abstract text is available yet for this article.
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27988935/perampanel-effects-in-the-wag-rij-rat-model-of-epileptogenesis-absence-epilepsy-and-comorbid-depressive-like-behavior
#20
Rita Citraro, Antonio Leo, Valentina Franco, Roberto Marchiselli, Emilio Perucca, Giovambattista De Sarro, Emilio Russo
OBJECTIVE: Perampanel (PER), a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor antagonist, exhibits broad-spectrum anticonvulsant activity in several seizure models, but its potential disease-modifying effects have not been investigated. Because of the relevance of AMPA receptors in epileptogenesis and psychiatric comorbidities, we studied the effects of PER in the WAG/Rij rat model of epileptogenesis, absence epilepsy, and depressive-like comorbidity...
December 18, 2016: Epilepsia
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