Gábor Nagy, Dezső Szikra, György Trencsényi, Anikó Fekete, Ildikó Garai, Arianna M Giani, Roberto Negri, Norberto Masciocchi, Alessandro Maiocchi, Fulvio Uggeri, Imre Tóth, Silvio Aime, Giovanni B Giovenzana, Zsolt Baranyai
Unprecedented fast and efficient complexation of Sc(III) was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the (44) Sc(AAZTA)(-) chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
January 18, 2017: Angewandte Chemie