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https://www.readbyqxmd.com/read/29031244/development-of-new-recombinant-dgk-antigen-for-diagnosis-of-dirofilaria-immitis-infections-in-dogs-using-elisa-technique-and-its-comparison-to-molecular-methods
#1
Rahmat Solgi, Seyed Mahmoud Sadjjadi, Mehdi Mohebali, Zabihollah Zarei, Majid Golkar, Abbasali Raz
Background: Dirofilaria immitis is a cosmopolitan zoonotic, vector-borne parasite of carnivorous animals causing dirofilariasis in human beings. Common commercial serodiagnostic tests for canine dirofilariasis usually lead to different results in their sensitivity and specificity. The present study reports development of recombinant DgK (rDgK) antigen of D. immitis for accurate immunodiagnosis of D. Immitis-infected dogs using indirect ELISA test. Methods: The rDgK coding sequence was successfully sequenced, codon optimized and cloned in pET-24a(+) expression vector and then expressed in Escherichia coli...
October 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29031179/carbosilane-metallodendrimers-based-on-copper-ii-complexes-synthesis-epr-characterization-and-anticancer-activity
#2
Natalia Sanz Del Olmo, Marta Maroto-Díaz, Rafael Gómez, Paula Ortega, Michela Cangiotti, M Francesca Ottaviani, F Javier de la Mata
A series of new organometallic carbosilane dendrimers functionalized with Copper(II) complex on the surface were synthesized and characterized as potential anticancer agents. These metallodendrimers were synthesized through the reaction of dendritic ligands containing N,N- and N,O- donor atoms able to act as chelating agents with CuCl2 as metallic ion precursor. The structural characterization of these complexes was addressed through the use of different analytical and spectroscopical techniques. Particularly, an electron paramagnetic resonance study was performed to corroborate the coordination properties of these dendritic ligands...
September 27, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29028356/aggregation-of-a-cationic-gemini-surfactant-with-a-chelating-molecule-and-effects-from-calcium-ion
#3
Weiwei Zhao, Kai Song, Yao Chen, Hua Wang, Zhang Liu, Qiang Shi, Jianbin Huang, Yilin Wang
The aggregation behavior of a cationic ammonium gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (12-6-12) with a chelating molecule ethylenediaminetetraacetic acid (EDTA) and the effects of calcium bromide (CaBr2) on the structure and morphology of the aggregates in the mixture have been investigated by surface tension, isothermal titration microcalorimetry, electrical conductivity, ζ potential, dynamic light scattering, cryogenic transmission electron microscopy, freeze-fracture transmission electron microscopy and 1H NMR techniques...
October 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29027934/angiotensin-i-converting-enzyme-ace-inhibitory-activity-antioxidant-properties-phenolic-content-and-amino-acid-profiles-of-fucus-spiralis-l-protein-hydrolysate-fractions
#4
Lisete Paiva, Elisabete Lima, Ana Isabel Neto, José Baptista
Food protein-derived hydrolysates with multi-bioactivities such as antihypertensive and antioxidant properties have recently received special attention since both activities can play significant roles in preventing cardiovascular diseases. This study reports, for the first time, the angiotensin I-converting enzyme (ACE)-inhibition and antioxidant properties of ultrafiltrate fractions (UF) with different molecular weight ranges (<1, 1-3 and ≥3 kDa) obtained from Fucus spiralis protein hydrolysate (FSPH) digested with cellulase-bromelain...
October 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29027287/role-of-the-diphosphine-chelate-in-emissive-charge-neutral-iridium-iii-complexes
#5
Jia-Ling Liao, Leon Devereux, Mark A Fox, Chun-Chieh Yang, Yu-Cheng Chiang, Chih-Hao Chang, Gene-Hsiang Lee, Yun Chi
A class of neutral tris-bidentate Ir(III) metal complexes incorporating a diphosphine as a chelate is prepared and characterized here for the first time. Treatment of [Ir(dppb)(tht)Cl3] (1) with fppzH afforded the dichloride complexes, trans-(Cl,Cl)[Ir(dppb)(fppz)Cl2] (2) and cis-(Cl,Cl)[Ir(dppb)(fppz)Cl2] (3). The reaction of 3 with the dianionic chelate precursor bipzH2 or mepzH2, in DMF gave the complex [Ir(dppb)(fppz)(bipz)] (4) or [Ir(dppb)(fppz)(mepz)] (5), respectively. In contrast, a hydride complex [Ir(dppb)(fppz)(bipzH)H] (6) was isolated instead of 4 in protic solvent, namely: DGME...
October 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29026055/childhood-lead-poisoning-an-overview
#6
REVIEW
K L Hon, C K Fung, A Kc Leung
Childhood lead poisoning is a major public health concern in many countries. In 2015, the Hong Kong SAR Government and its citizens faced a major public health crisis due to the presence of lead in the drinking water of a number of public housing estates. Fortunately, no child was diagnosed with lead poisoning that required treatment with chelation. Lead is a ubiquitous, naturally occurring material that exists in air, dust, soil, and water. It is also widely present in industrial products including petrol, paints, ceramics, food cans, candies, cosmetics, traditional remedies, batteries, solder, stained glass, crystal vessels, ammunition, ceramic glazes, jewelry, and toys...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29025988/advanced-methods-for-radiolabelling-nanomedicines-for-multi-modality-nuclear-mr-imaging
#7
Jennifer R Lamb, Jason P Holland
The advent of hybrid cameras that combine magnetic resonance imaging with either single-photon emission computed tomography (SPECT/MRI) or positron-emission tomography (PET/MRI) has stimulated growing interest in developing multi-modality imaging probes. Countless options are available for fusing magnetically active species with positron- or gamma-ray emitting radionuclides. The initial problem is one of choice: which chemical systems are a suitable basis for developing hybrid imaging agents? Any attempt to answer this question must also address how the physical, chemical, and biological properties of a unified imaging agent can be tailored to ensure that optimum specificity and contrast is achieved simultaneously for both imaging modalities...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025987/preclinical-development-of-cd38-targeted-89-zr-zr-dfo-daratumumab-for-imaging-multiple-myeloma
#8
Anchal Ghai, Dolonchampa Maji, Michael Rettig, Chantiya Chanswangphuwana, John DiPersio, Walter Akers, Samuel Achilefu, Farrokh Dehdashti, Ravi Vij, Monica Shokeen
Multiple myeloma (MM) is a plasma B-cell hematologic cancer that causes significant skeletal morbidity. Despite improvements in survival, heterogeneity in response remains a major challenge in MM. Cluster of differentiation 38 (CD38) is a type II transmembrane glycoprotein over-expressed in myeloma cells and is implicated in MM cell signaling. Daratumumab is US Food and Drug Administration approved high-affinity monoclonal antibody targeting CD38 that is clinically benefiting refractory MM patients. Here, we evaluated [(89)Zr]Zr-DFO-daratumumab positron emission tomography/computed tomography (PET/CT) imaging in MM tumor models...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025321/rutin-ameliorates-oxidative-stress-and-preserves-hepatic-and-renal-functions-following-exposure-to-cadmium-and-ethanol
#9
Sunny O Abarikwu, Rex-Clovis Njoku, Chiamaka J Lawrence, Iniobong A Charles, Jude C Ikewuchi
CONTEXT: Rutin (RUT) is an antioxidant flavonoid with well-known metal chelating potentials. OBJECTIVE: This study was designed to evaluate the protective effects of RUT against cadmium (Cd) + ethanol (EtOH)-induced hepatic and renal toxicity in rats. MATERIALS AND METHODS: Wistar rats were treated with Cd (50 mg/kg) alone or in combination with EtOH (5 mg/kg) and RUT (25, 50 and 100 mg/kg) for 15 days. After treatment, the liver, kidney and serum were removed for biochemical assays by spectrophotometric methods...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29024506/a-near-infrared-responsive-drug-sequential-release-system-for-better-eradicating-amyloid-aggregates
#10
Mengmeng Ma, Nan Gao, Yuhuan Sun, Jinsong Ren, Xiaogang Qu
Polyphenol compounds, such as curcumin, rutin, rifampicin, can inhibit Aβ aggregation and decrease reactive oxygen species (ROS), and have received much attention in recent years for Alzheimer's disease (AD) treatment. However, the excess metal ions in amyloid plaque can chelate to polyphenol compounds. It significantly declines the efficacy of polyphenol compounds when used in the clinic. In this report, a near-infrared (NIR)-caged upconversion responsive system UCNP@SiO2 @Cur/CQ is designed and synthesized to control drug sequential release by regulating NIR laser...
October 12, 2017: Small
https://www.readbyqxmd.com/read/29024271/impact-of-long-range-electronic-effect-of-fluorous-ponytail-on-metal-coordination-during-solvent-extraction
#11
Bertrand Braibant, Xavier Le Goff, Damien Bourgeois, Daniel Meyer
With the need for a precise description of the long range electronic effects of a perfloroalkyl chain (F-ponytail) grafted on metal chelators, we studied in detail the effect of a spacer inserted between the polar complexing head and the F-ponytail, in relation with the metal coordination ability of the resulting molecules. The prepared molecules were then employed for the extraction of various metals from an aqueous phase into an organic phase, and the optimum spacer length could be estimate between three and four methylene units, according to the extraction conditions...
October 11, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29024055/metal-ligand-multiple-bonding-in-thorium-phosphorus-and-arsenic-complexes
#12
Justin Walensky, Sean P Vilanova, Patrick Huang, Pinar Alayoglu, Mohammad Heidarian
The complexes (C5Me5)2Th(EHTipp)2, (E = P or As, Tipp = 2,4,6-triisopropylphenyl), provide a ligand framework that results in facile access to rare Th-E multiple bonds. The reaction of (C5Me5)2Th(EHTipp)2 with KN(SiMe3)2, proceeds cleanly to the desired bridging phosphinidiide or arsinidiide complex, [{(C5Me5)2Th(μ2-ETipp(μ2-EHTipp)}K]2 under ambient conditions. In the absence of a chelating agent, the potassium cation of one monomeric unit interacts with the aryl ring of a second monomer to form a bridged dimer...
October 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29024047/a-gallium-hydride-as-an-oxidizing-agent-direct-synthesis-of-ir-v-complexes-via-ga-h-bond-activation
#13
Simon Aldridge, Alexa Caise, Joseph Abdalla, Remi Tirfoin, Alison Edwards
Reactions of the β-diketiminate stabilized gallium dihydride (Nacnac)DippGaH2 with chelating Ir(I) bis(phosphine) precursors under an H2 atmosphere are shown to provide a simple route to Ir(V) complexes stabilized by strongly σ-donating hydrides and the carbene-like (Nacnac)DippGa donor. Characterization of these systems as seven-coordinate Ir(V) tetrahydride species is supported by single crystal X-ray and neutron diffraction, and by T1 NMR measurements. By contrast, related systems featuring more sterically demanding (non-chelating) ancillary ligands are better described in terms of a bis(hydride) dihydrogen [L3Ir(H)2(H2)]+ formulation and a formal Ir(III) oxidation state...
October 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29023951/synthesis-99m-tc-labeling-and-preliminary-biological-evaluation-of-dtpa-melphalan-conjugates
#14
Jianjun Wang, Wenjiang Yang, Jinquan Xue, Yanhua Zhang, Yu Liu
Melphalan (MFL) is a typical nitrogen mustard for the treatment of many types of cancer. For the purpose to develop novel (99m) Tc-labeled tumor imaging agents with SPECT, MFL was directly labeled by (99m) Tc using DTPA (diethylene triamine pentacetate acid) as bifunctional chelating agent. The novel ligands were successfully synthesized by conjugation of DTPA to melphalan to get mono-substituted DTPA-MFL and bis-substituted DTPA-2MFL. Radiolabeling was performed in high yield to get (99m) Tc-DTPA-MFL and (99m) Tc-DTPA-2MFL respectively, which were hydrophilic and stable at room temperature...
October 11, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29023459/chlorophyte-aspartyl-aminopeptidases-ancient-origins-expanded-families-new-locations-and-secondary-functions
#15
Sang-Youl Park, Melissa A Scranton, Jason E Stajich, Ashley Yee, Linda L Walling
M18 aspartyl aminopeptidases (DAPs) are well characterized in microbes and animals with likely functions in peptide processing and vesicle trafficking. In contrast, there is a dearth of knowledge on plant aminopeptidases with a preference for proteins and peptides with N-terminal acidic residues. During evolution of the Plantae, there was an expansion and diversification of the M18 DAPs. After divergence of the ancestral green algae from red and glaucophyte algae, a duplication yielded the DAP1 and DAP2 lineages...
2017: PloS One
https://www.readbyqxmd.com/read/29022989/prophylactic-intravenous-calcium-therapy-for-exchange-blood-transfusion-in-the-newborn
#16
REVIEW
Tinuade A Ogunlesi, Foluso Ea Lesi, Olabisi Oduwole
BACKGROUND: Exchange blood transfusion (EBT) is a form of whole blood transfusion in which the total blood volume is replaced within a few hours. In perinatal and neonatal medicine, EBT is most often used in the management of severe anaemia or severe hyperbilirubinaemia in the first week of life. Hypocalcaemia, one of the common morbidities associated with EBT, is thought to arise from the chelating effects of the citrate commonly used as an anticoagulant in the donor's blood. This disorder manifests with muscular and nervous irritability and cardiac arrhythmias...
October 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29022631/pd-catalyzed-c-h-arylation-of-pyridazine-based-fused-1-2-4-triazoles-overriding-selectivity-at-the-usual-position-by-undermining-of-preferred-chelate-formation
#17
Ramasamy Srinivasan, Aniruddha Dey, N Shanmugam Nagarajan, Rajendran Senthil Kumaran, Thirumanavelan Gandhi, Debabrata Maiti
The applicability of C-H functionalization to medicinally important 2-pyridyl-based N-heterocycles suffers from severe challenges owing to the high Lewis basicity of the N-atom. This arrests catalytic activity and yields undesirable positional selectivity due to preferential chelate formation. In this regard, we report a novel palladium(ii)-catalyzed arylation strategy on multiple-N-containing pyridazines by over-riding the functionalization due to a chelated palladacycle. We report a regioselective mono-arylation at the 8-position of diphenyl azolopyridazines without any ortho-C-H activation on the proximal phenyl groups...
October 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29022617/two-titanium-iv-oxo-clusters-synthesis-structures-characterization-and-recycling-catalytic-activity-in-the-oxygenation-of-sulfides
#18
Rong-Hui Wu, Ming Guo, Ming-Xin Yu, Long-Guan Zhu
Two 5-sulfosalicylic acid (H3ssal) and 1,10-phenanthroline (Phen) substituted titanium-oxo-clusters, [Ti6O8 (Hssal)2(Phen)6(H2O)4]·4OH·21H2O (TOC-1) and [Ti4O4(Hssal)4(Phen)4]·18H2O·4NH3 (TOC-2), have been synthesized and fully characterized by single crystal X-ray diffraction, FT-IR spectroscopy, elemental analysis, thermogravimetric analysis and fluorescence analysis. The structure of TOC-1 is a hexanuclear cluster containing a {Ti6(μ2-O)8} core, where all titanium ions can be described in a distorted octahedral geometry with both 1,10-phenanthroline and 5-sulfosalicylate serving as chelating ligands, while TOC-2 consists of a tetranuclear {Ti4(μ2-O)4} skeleton forming an approximate plane quadrilateral where both 5-sulfosalicylate and 1,10-phenanthroline ligands chelate to the titanium atom and the oxygen atom bridges two titanium atoms...
October 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29022152/microwave-assisted-combustion-synthesis-of-zno-eu-nanoparticles-effect-of-fuel-types
#19
Sousan Rasouli, Amir-Masoud Arabi, Alireza Naeimi, Seyed-Masoud Hashemi
Nanoparticles of Europium oxide doped with Zinc oxide were synthesized via microwave-assisted combustion method. Citric acid as a simultaneous fuel and chelating agent and glycine as a fuel and mixture of these fuels were sleeted. X-Ray diffraction patterns (XRD) indicated the formation of ZnO structure with a few amount of Eu2O3 phase. Fourier transformation infra red (FTIR) spectra reveal the increase of ZnO4 bonds with glycine content of fuels mixture. Scanning electron microscope (SEM) images showed the conversion of nanosphere to spongy-like structure with respect to change of fuel mixtures from citric to glycine...
October 11, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29021804/calcium-and-calmodulin-are-involved-in-nitric-oxide-induced-adventitious-rooting-of-cucumber-under-simulated-osmotic-stress
#20
Lijuan Niu, Jian Yu, Weibiao Liao, Jihua Yu, Meiling Zhang, Mohammed M Dawuda
Osmotic stress is a major form of abiotic stress that adversely affects growth and development of plants and subsequently reduces yield and quality of crops. In this study, the effect of nitric oxide (NO) and calcium (Ca(2+)) on the process of adventitious rooting in cucumber (Cucumis sativus L.) under simulated osmotic stress was investigated. The results revealed that the effect of exogenous NO and Ca(2+) in promoting the development of adventitious roots in cucumber seedlings under simulated osmotic stress was dose-dependent, with a maximal biological response at 10 μM NO donor nitroprusside (SNP) or 200 μM Ca(2+)...
2017: Frontiers in Plant Science
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