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https://www.readbyqxmd.com/read/28454075/a-novel-highly-sensitive-selective-reversible-and-turn-on-chemi-sensor-based-on-schiff-base-for-rapid-detection-of-cu-ii
#1
Sayed M Saleh, Reham Ali, Ibrahim A I Ali
In this work, a novel optical fluoro-chemisensor was designed and synthesized for copper (II) ions detection. The sensor film is created by embedded N,N-Bis(2-hydroxo-5-bromobenzyl)ethylenediamine in poly vinyl chloride (PVC) film in presence of dioctyl phthalate (DOP) as plasticizer. The receptor Schiff base reveals "off-on" mode with high selectivity, significant sensitivity to Cu(II) ions. The selectivity of optical sensor for Cu(II) ions is the result of chelation enhanced fluorescence (CHEF). The optimal conditions of pH and response time at which higher efficiency of sensor film is performed was found to be 6...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28453480/a-multifunctional-biocompatible-drug-candidate-is-highly-effective-in-delaying-pathological-signs-of-alzheimer-s-disease-in-5xfad-mice
#2
Hadar Segal-Gavish, Ortal Danino, Yael Barhum, Tali Ben-Zur, Ella Shai, David Varon, Daniel Offen, Bilha Fischer
BACKGROUND: Metal-ion-chelation was suggested to prevent zinc and copper ions-induced amyloid-β (Aβ) aggregation and oxidative stress, both implicated in the pathophysiology of Alzheimer's disease (AD). In a quest for biocompatible metal-ion chelators potentially useful for AD therapy, we previously tested a series of nucleoside 5'-phosphorothioate derivatives as agents for decomposition of Cu(I)/Cu(II)/Zn(II)-Aβ-aggregates, and as inhibitors of OH radicals formation in Cu(I) or Fe(II) /H2O2 solution...
April 28, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28453272/bacterial-iron-uptake-pathways-gates-for-the-import-of-bactericide-compounds
#3
Isabelle J Schalk, Gaëtan L A Mislin
Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidrug resistant bacteria, especially Gram-negative bacteria for which the situation is particularly critical. Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a promising strategy able to considerably increase the efficacy of drugs. Such a Trojan horse strategy can also extend activity of specific Gram-positive antibiotics to Gram-negative bacteria...
April 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28449230/metal-free-arene-and-heteroarene-borylation-catalyzed-by-strongly-electrophilic-bis-boranes
#4
Gerhard Erker, Yun-Lin Liu, Gerald Kehr, Constantin G Daniliuc
The geminal chelate bis-borylalkanes 4 and 5 featuring strongly electrophilic B(C6F5)2 and B(C6F5) groups, respectively, serve as efficient catalysts for the borylation of arenes and heteroarenes. The borylation reactions proceed under mild conditions with liberation of dihydrogen.
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28448199/deferiprone-for-the-treatment-of-transfusional-iron-overload-in-thalassemia
#5
Janet L Kwiatkowski, Ami Belmont
Transfusional iron overload can lead to hepatic fibrosis, arrhythmias and congestive heart failure and a number of endocrinopathies. Deferiprone is an oral iron chelator recently approved for use in the United States as a second line agent for the treatment of transfusional iron overload in patients with thalassemia. Areas covered: This article will review the data regarding the efficacy of deferiprone for iron chelation and prevention and reversal of iron related complications, the drug's adverse effect profile, and the use of this drug in combination regimens...
April 27, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28448155/cp-co-iii-catalyzed-annulation-of-carboxylic-acids-with-alkynes
#6
Rajib Mandal, Basker Sundararaju
A new procedure for oxidative coupling of aromatic and acrylic acids with alkynes has been developed using abundant, nontoxic, and air stable Cp*Co(III) catalyst. The coupling involves initial cyclometalation via weak chelation-assisted C-H bond activation followed by alkyne coordination, insertion, and reductive elimination leading to diverse isocoumarins (α-pyranones) in good yields under mild conditions.
April 27, 2017: Organic Letters
https://www.readbyqxmd.com/read/28448127/organo-copper-ii-complexes-as-products-of-radical-atom-transfer
#7
Timothy J Zerk, Paul V Bernhardt
Copper complexes bearing polyamine chelate ligands are among the most widely used and highly active catalysts for atom transfer radical polymerization (ATRP). Copper(I) complexes of these ligands (Cu(I)L) react with an alkyl halide initiator (RX) in the atom transfer step to generate the higher oxidation state halido complex Cu(II)LX and the radical R(•). However, Cu(I)L present in the reaction also has the potential to react with the liberated radicals to generate the organometallic species Cu(II)LR (where R is formally a carbanion)...
April 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28447978/high-resolution-thermal-micro-imaging-using-europium-chelate-luminescent-coatings
#8
Timothy M Benseman, Yang Hao, Vitalii K Vlasko-Vlasov, Ulrich Welp, Alexei E Koshelev, Wai-Kwong Kwok, Ralu Divan, Courtney Keiser, Chiharu Watanabe, Kazuo Kadowaki
Micro-electronic devices often undergo significant self-heating when biased to their typical operating conditions. This paper describes a convenient optical micro-imaging technique which can be used to map and quantify such behavior. Europium thenoyltrifluoroacetonate (EuTFC) has a 612 nm luminescence line whose activation efficiency drops strongly with increasing temperature, due to T-dependent interactions between the Eu(3+) ion and the organic chelating compound. This material may be readily coated on to a sample surface by thermal sublimation in vacuum...
April 16, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28446716/targeted-alpha-therapy-using-a-novel-cd70-targeted-thorium-227-conjugate-in-in-vitro-and-in-vivo-models-of-renal-cell-carcinoma
#9
Urs B Hagemann, Dessislava Mihaylova, Steinar R Uran, Joergen Borrebaek, Derek Grant, Roger M Bjerke, Jenny Karlsson, Alan S Cuthbertson
The cell surface receptor CD70 has been previously reported as a promising target for B-cell lymphomas and several solid cancers including renal cell carcinoma. We describe herein the characterization and efficacy of a novel CD70 targeted thorium-227 conjugate (CD70-TTC) comprising the combination of the three components, a CD70 targeting antibody, a chelator moiety and the short-range, high-energy alpha-emitting radionuclide thorium-227 (227Th). In vitro analysis demonstrated that the CD70-TTC retained binding affinity to its target and displayed potent and specific cytotoxicity compared to an isotype control-TTC...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28446358/diagnostic-use-of-chelating-agents
#10
Peter Jennrich
No abstract text is available yet for this article.
April 7, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28444586/cereal-phytases-and-their-importance-in-improvement-of-micronutrients-bioavailability
#11
REVIEW
Amit Vashishth, Sewa Ram, Vikas Beniwal
Phytic acid is a main reservoir of phosphorous (P) in plants and contributes to about 80% of the total P in cereal seeds. However, it is well known to possess anti-nutritional behavior. Because it has strong affinity to chelate divalent ions e.g. calcium, magnesium, and especially with iron and zinc. Therefore, it is extremely poor as a dietary source of P. To enhance bio-availability of micronutrients, an enzyme namely phytase is known to hydrolyze phytic acid. Unfortunately, phytase is not produced in the stomach of monogastric animals and humans...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28443662/bis-tert-butylimido-bis-n-o-chelate-tungsten-vi-complexes-probing-amidate-and-pyridonate-hemilability
#12
Joseph M Clarkson, Laurel L Schafer
Four new bis(tert-butylimido)bis(N,O-chelate)tungsten(VI) complexes (3-6), in which the N,O-chelate is an amidate or pyridonate ligand, have been synthesized and characterized. Computational analysis has been used to calculate the relative energies of different stereoisomers and shown how the steric demand of each ligand influences coordination and bonding modes. The electronically saturated complexes have been employed to evaluate 1,3-N,O-chelated metal-ligand interactions. Complexes 3-6 were treated with electrophilic reagents, which resulted in strikingly different reactivity patterns between the amidate and the pyridonate ligated complexes...
April 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28443520/recent-advances-on-3-hydroxyflavone-derivatives-structures-and-properties
#13
Burcu Butun, Gulacti Topcu, Turan Ozturk
Flavonoids are naturally occurring phenolic compounds named as 2-phenyl-1-benzopyran-4-one and classified into several subclasses according to their basic chemical structures such as flavones, flavonols, flavanones, flavanonols, and flavanols. Among them, flavonols (3-hydroxyflavone), containing a 3-hydroxyl group in association with its 4-keto group and double bond between 2- and 3- carbon atoms, have the best electron conjugated skeleton in flavonoid family, providing several resonance structures and chelating ability, through which various pharmacological activities such as antiviral, antitumor, anti-inflammatory, anticholinesterase, cytotoxicity, and particularly high antioxidant activity are demonstrated...
April 24, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28443510/a-combination-of-egg-yolk-igy-and-phosvitin-inhibits-the-growth-of-enterotoxigenic-escherichia-coli-k88-and-k99
#14
Naiyana Gujral, Heejoo Yoo, Fatemeh Bamdad, Kwang Yong Lee, Joo-Won Suh, Hoon Sunwoo
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is the main cause of fatal diarrhea in piglets during the first week of life and over the time of weaning. Pathogenesis of ETEC-causing diarrhea involves intestinal colonization mediated by fimbriae. Although, both IgY and egg yolk phosvitin (PV) possess antimicrobial activity, their combined activity has not been explored. A combination of IgY specific for ETEC and metal-chelating PV may show synergistic effect in reducing the growth of ETEC by inhibiting bacterial proliferation and stipulating protection against ETEC infection...
April 25, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28443330/mechanisms-by-which-salt-concentration-moderates-the-dynamics-of-human-serum-transferrin
#15
Haleh Abdizadeh, Ali Rana Atilgan, Canan Atilgan
The dynamical and thermodynamic behavior of human transferrin (hTf) protein in saline aqueous solution of various concentrations is studied. hTf is an essential transport protein circulating iron in the blood and delivering it to tissues. It displays highly pH dependent cooperativity between the two lobes each carrying an iron, and forms a tight complex with the receptor during endocytosis, eventually recycled to the serum after iron release. Molecular dynamics simulations are used to investigate the effects of the amount of salt on protein conformation and dynamics to analyze the structure-function relationship in free hTf at serum pH...
April 26, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28443261/diabetes-mellitus-caused-by-secondary-hemochromatosis-after-multiple-blood-transfusions-in-2-patients-with-severe-aplastic-anemia
#16
Hyun Jin Kim, Yoon-Myung Kim, Eungu Kang, Beom Hee Lee, Jin-Ho Choi, Han-Wook Yoo
Hemochromatosis is an inherited or secondary disorder caused by excessive iron storage leading to multiple organ damage. We describe 2 patients with diabetes mellitus caused by hemochromatosis secondary to multiple blood transfusions due to severe aplastic anemia. Subject 1, who was diagnosed with severe aplastic anemia at 15 years of age, received multiple red blood cell transfusions before he underwent autologous peripheral blood stem cell transplantation (PBSCT) at 22 years of age. At 21 years of age, hyperglycemia was detected with increased hemoglobin A1c and serum ferritin levels, 9...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28442170/platinum-palladium-gold-and-ruthenium-complexes-as-anticancer-agents-current-clinical-uses-cytotoxicity-studies-and-future-perspectives
#17
REVIEW
Tatjana Lazarević, Ana Rilak, Živadin D Bugarčić
Metallodrugs offer potential for unique mechanism of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging. Current research addressing the problems associated with platinum drugs has focused on other metal-based therapeutics that have different modes of action and on prodrug and targeting strategies in an effort to diminish the side-effects of cisplatin chemotherapy...
April 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28440833/structure-function-studies-of-acinetobactin-analogs
#18
Justin A Shapiro, Timothy A Wencewicz
Pathogenic Acinetobacter baumannii excrete the siderophore pre-acinetobactin as an iron-scavenging virulence factor. Pre-acinetobactin is a 2,3-dihydroxy-phenyl oxazoline that undergoes pH-dependent isomerization to the isooxazolidinone form acinetobactin in order to expand the pH range for iron acquisition by A. baumannii. In this study we establish important structure-function relationships for the kinetics of isomerization, iron(iii) binding, and siderophore utilization by A. baumannii. We showed that electronic properties of the phenyl oxazoline influence isomerization kinetics and iron(iii) binding...
April 25, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28440111/quality-of-life-outcomes-in-a-pediatric-thalassemia-population-in-egypt
#19
Soheir Adam, Hanan Afifi, Manal Thomas, Phoebe Magdy, Ghada El-Kamah
Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-thalassemias major (β-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to mitigate the effects of the resultant iron overload. Clinical disease burden and the demanding treatment can affect health-related quality of life (HRQoL) outcomes in this population. The aim of this study was to assess HRQoL outcomes in Egyptian pediatric thalassemia patients...
April 25, 2017: Hemoglobin
https://www.readbyqxmd.com/read/28439959/chemical-and-biological-aspects-of-nutritional-immunity-perspectives-for-new-anti-infectives-targeting-iron-uptake-systems
#20
Sabine Laschat, Ursula Bilitewski, Joshua Blodgett, Anne-Kathrin Duhme-Klair, Sabrina Dallavalle, Anne Routledge, Rainer Schobert
Upon bacterial infection one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron leading to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, e.g. by stealing iron from the host or other bacteria by specific iron chelators with high binding affinity. Fortunately, these complex interactions between host and pathogen regarding metal homeostasis provide several opportunities for interception and thus allow the development of novel antibacterials...
April 25, 2017: Angewandte Chemie
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