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https://www.readbyqxmd.com/read/29245145/comparative-leaching-of-six-toxic-metals-from-raw-and-chemically-stabilized-mswi-fly-ash-using-citric-acid
#1
Huawei Wang, Xinxiu Fan, Ya-Nan Wang, Weihua Li, Yingjie Sun, Meili Zhan, Guizhi Wu
The leaching behavior of six typical toxic metals (Pb, Zn, Cr, Cd, Cu and Ni) from raw and chemically stabilized (phosphate and chelating agent) municipal solid waste incineration (MSWI) fly ash were investigated using citric acid. Leaching tests indicated that phosphate stabilization can effectively decrease the leaching of Zn, Cd and Cr; whereas chelating agent stabilization shows a strong ability to lower the release of Pb, Cd and Cu, but instead increases the solubility of Zn and Cr at low pH conditions...
December 12, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29243062/pre-clinical-study-of-a-tnfr1-targeted-18f-probe-for-pet-imaging-of-breast-cancer
#2
Hao Fu, Hua Wu, Xianzhong Zhang, Jinxiong Huang, Xiaojiang He, Lichun Chen, Wei Guo, Xiuyu Guo, Bing Hao, Yesen Li
Tumor necrosis factor receptor 1 (TNFR1) is overexpressed in several varieties of carcinoma, including breast cancer. WH701 (Ala-Thr-Ala-Gln-Ser-Ala-Tyr-Gly), which was identified by phage display, can specifically bind to TNFR1. In this study, we labeled WH701 with 18F and investigated its tumor diagnostic value. WH701 was synthesized by standard Fmoc-solid phase synthetic protocols and conjugated by NOTA-NHS. NOTA-WH701 was radiolabeled with 18F using NOTA-AlF chelation reaction. The tumor target properties were evaluated in vitro and in vivo using MCF-7 xenografts and inflammation models...
December 14, 2017: Amino Acids
https://www.readbyqxmd.com/read/29241581/iron-induced-chelation-alleviates-the-potential-allergenicity-of-ovotransferrin-in-a-balb-c-mouse-model
#3
Ping Tong, Lin Gao, Jinyan Gao, Xin Li, Zhihua Wu, Anshu Yang, Hongbing Chen
Ovotransferrin (OVT) is one of the main egg allergens with 2 iron-binding sites. Several studies have demonstrated that iron-chelation decreased the allergenicity of milk allergen and birch pollen allergens. Therefore, we hypothesized that iron-chelation could also reduce the allergenicity of OVT. Apo-OVT (iron-free OVT, the natural state in egg white) and Holo-OVT (iron-chelated OVT) were prepared, and the allergenicity of them were assessed and compared using a BALB/c mouse model as well as dendritic cells (DCs) based on antigen uptake...
November 2017: Nutrition Research
https://www.readbyqxmd.com/read/29241117/influence-of-direct-and-alternating-current-electric-fields-on-efficiency-promotion-and-leaching-risk-alleviation-of-chelator-assisted-phytoremediation
#4
Jie Luo, Limei Cai, Shihua Qi, Jian Wu, Xiaowen Sophie Gu
Direct and alternating current electric fields with various voltages were used to improve the decontamination efficiency of chelator assisted phytoremediation for multi-metal polluted soil. The alleviation effect of electric field on leaching risk caused by chelator application during phytoremediation process was also evaluated. Biomass yield, pollutant uptake and metal leaching retardation under alternating current (AC) and direct current (DC) electric fields were compared. The biomass yield of Eucalyptus globulus under AC fields with various voltages (2, 4 and 10 V) were 3...
December 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29240422/high-in-vivo-stability-of-64cu-labeled-cross-bridged-chelators-is-a-crucial-factor-in-improved-tumor-imaging-of-rgd-peptide-conjugates
#5
Swarbhanu Sarkar, Nikunj Bhatt, Yeong Su Ha, Phuong Tu Huynh, Nisarg Soni, Woong Hee Lee, Yong Jin Lee, Jung Young Kim, Darpan N Pandya, Gwang Il An, Kyo Chul Lee, Yongmin Chang, Jeongsoo Yoo
Although the importance of bifunctional chelators (BFCs) is well recognized, the chemophysical parameters of chelators that govern the biological behavior of the corresponding bioconjugates have not been clearly elucidated. Here, five BFCs closely related in structure were conjugated with a cyclic RGD peptide and radiolabeled with Cu-64 ions. Various biophysical and chemical properties of the Cu(II) complexes were analyzed with the aim of identifying correlations between individual factors and the biological behavior of the conjugates...
December 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29239443/-ag15-n-triphos-4-cl4-no3-3-a-stable-ag-p-superatom-with-eight-electrons-n-triphos-tris-diphenylphosphino-methyl-amine
#6
Xue-Tao Shen, Xue-Li Ma, Qing-Ling Ni, Meng-Xia Ma, Liu-Cheng Gui, Cheng Hou, Ruo-Bing Hou, Xiu-Jian Wang
A first and stable Ag-P superatom nanocluster [Ag15(N-triphos)4(Cl4)](NO3)3 (1) has been successfully synthesized and characterized. X-ray analysis shows that this Ag15 cluster has a hexacapped body-centered cubic (bcc) framework which is consolidated by four tripodal N-triphos ligands. The identity of 1 is confirmed by high resolution ESI-MS. Cluster 1 has an electronic and geometric shell closure structure with 8 free electrons, matching the stability idea of superatom theory for a nanocluster. DFT calculation of this Ag15 cluster reveals the superatom feature with a 1S21P6 configuration...
December 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/29238189/diethyl-citrate-and-sodium-citrate-reduce-the-cytotoxic-effects-of-nanosized-hydroxyapatite-crystals-on-mouse-vascular-smooth-muscle-cells
#7
Chong-Yu Zhang, Xin-Yuan Sun, Jian-Ming Ouyang, Bao-Song Gui
Objective: This study aimed to investigate the damage mechanism of nanosized hydroxyapatite (nano-HAp) on mouse aortic smooth muscle cells (MOVASs) and the injury-inhibiting effects of diethyl citrate (Et2Cit) and sodium citrate (Na3Cit) to develop new drugs that can simultaneously induce anticoagulation and inhibit vascular calcification. Methods: The change in cell viability was evaluated using a cell proliferation assay kit, and the amount of lactate dehydrogenase (LDH) released was measured using an LDH kit...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29237257/iron-homeostasis-controls-myeloid-blood-cell-differentiation-in-drosophila
#8
Sunggyu Yoon, Bumsik Cho, Mingyu Shin, Ferdinand Koranteng, Nuri Cha, Jiwon Shim
Iron is an essential divalent ion for aerobic life. Life has evolved to maintain iron homeostasis for normal cellular and physiological functions and therefore imbalances in iron levels exert a wide range of consequences. Responses to iron dysregulation in blood development, however, remain elusive. Here, we found that iron homeostasis is critical for differentiation of Drosophila blood cells in the larval hematopoietic organ, called the lymph gland. Supplementation of an iron chelator, bathophenanthroline disulfate (BPS) results in an excessive differentiation of the crystal cell in the lymph gland...
December 14, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29236348/isolation-of-a-reactive-tricoordinate-alpha-oxo-gold-carbene-complex
#9
Abdallah Zeineddine, Feriel Rekhroukh, E Daiann Sosa Carrizo, Sonia Mallet-Ladeira, Karinne Miqueu, Abderrahmane Amgoune, Didier Bourissou
The [(P,P)Au=C(Ph)CO2Et]+ complex 3 [where (P,P) is an o-carboranyl diphosphine ligand] was prepared by diazo decomposition at -40°C. It is the first alpha-oxo gold carbene complex to be characterized. Its crystallographic structure was determined and DFT calculations have been performed, unraveling the key influence of the chelating (P,P) ligand. The gold center is tricoordinate and the electrophilicity of the carbene center is reduced. Complex 3 mimics transient alpha-oxo gold carbenes in a series of catalytic transformations, and enables to support the critical role of electrophilicity in the chemoselectivity of phenol functionalization (O-H vs C-H insertion)...
December 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29235740/thalassemia-major-and-intermedia-in-patients-older-than-35-years-a-single-center-experience
#10
Liat Shargian-Alon, Oren Pasvolsky, Pia Raanani
BACKGROUND: During the past decades, beta thalassemia major (TM) and beta thalassemia intermedia (TI) have transformed from a universally fatal disease at a young age into a chronic disease. This advancement is attributed to improved chelation therapy as well as enhanced management strategies, with focused attention on disease and treatment-related complications. OBJECTIVES: To describe characteristics of adults with thalassemia as well as treatment modalities, disease and treatment-related complications, and socioeconomic information of the patients...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29235601/ruthenium-ii-arene-nsaid-complexes-inhibition-of-cyclooxygenase-and-antiproliferative-activity-against-cancer-cell-lines
#11
Poulami Mandal, Bidyut Kumar Kundu, Komal Vyas, Vidya Sabu, A Helen, Sandeep Singh Dhankhar, C M Nagaraja, Debojit Bhattacherjee, Krishna Pada Bhabak, Suman Mukhopadhyay
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of molecules which have been found to be active against cancer cells with chemopreventive properties by targeting cyclooxygenase (COX-1 and COX-2) and lipoxygenase (LOX), commonly upregulated (particularly COX-2) in malignant tumors. Arene ruthenium(ii) complexes with a pseudo-octahedral coordination environment containing different ancillary ligands have shown remarkable activity against primary and metastatic tumors as reported earlier. This work describes the synthesis of four novel ruthenium(ii)-arene complexes viz...
December 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29235227/peptide-based-fluorescent-probes-for-deacetylase-and-decrotonylase-activity-toward-a-general-platform-for-real-time-detection-of-lysine-deacylation
#12
Debra R Rooker, Yuliya Klyubka, Ritika Gautam, Elisa Tomat, Daniela Buccella
Histone deacetylases regulate acetylation levels of numerous proteins and play key roles in physiological processes as well as disease states. In addition to acetyl groups, deacetylases can remove other acyl modifications on lysines whose roles and regulation are far less understood. We report herein a peptide-based fluorescent probe for single-reagent, real time detection of deacetylase activity that can be readily adapted for probing broader lysine deacylation, including decrotonylation. Following cleavage of the lysine modification, the probe undergoes rapid intramolecular imine formation that results in marked optical changes, thus enabling convenient detection of deacylase activity with good statistical Z' factors for both absorption and fluorescence modalities...
December 12, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29235206/sperm-storage-influences-the-potential-for-spontaneous-acrosome-reaction-of-the-sperm-in-the-newt-cynops-pyrrhogaster
#13
Shinnosuke Kon, Tae Sato, Daisuke Endo, Tomoe Takahashi, Akio Takaku, Yuni Nakauchi, Fubito Toyama, Victor B Meyer-Rochow, Eriko Takayama-Watanabe, Akihiko Watanabe
Sperm storage is supposed to influence sperm quality, although the details remain unclear. In the present study, we found that sperm stored in a sperm storage site, the vas deferens of Cynops pyrrhogaster, spontaneously undergo acrosome reaction following incubation in Steinberg's salt solution (ST). Percentages of acrosome-reacted sperm increased time-dependently to about 60% in 24 hr. The concentration of cyclic adenosine monophosphate (cAMP) was elevated after incubating sperm in ST, while dibutylyl cAMP induced an acrosome reaction...
November 20, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29235162/iron-chelating-effect-of-silymarin-in-patients-with-%C3%AE-thalassemia-major-a-crossover-randomised-control-trial
#14
Hadi Darvishi-Khezri, Ebrahim Salehifar, Mehrnoush Kosaryan, Hossein Karami, Mohammadreza Mahdavi, Abbas Alipour, Aily Aliasgharian
This study aimed to determine the potential iron-chelating effects of silymarin in patients with β-thalassemia major receiving standard iron-chelation therapy. We evaluated whether addition of silymarin to standard iron-chelation therapy could improve iron burden markers and liver and cardiac function in these patients, via a placebo-controlled, crossover clinical study. Silymarin (140 mg) or placebo were administered thrice daily to all patients (n = 82) for 12 weeks, and after a 2-week washout period, patients were crossed over to the other groups...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29235028/artificial-intelligence-and-regression-analysis-for-cd-ii-ion-biosorption-from-aqueous-solution-by-gossypium-barbadense-waste
#15
Manal Fawzy, Mahmoud Nasr, Heba Nagy, Shacker Helmi
In this study, batch biosorption experiments were conducted to determine the removal efficiency of Cd(II) ion from aqueous solutions by Gossypium barbadense waste. The biosorbent was characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) connected with energy dispersive X-ray (EDX). The sorption mechanism was described by complexation/chelation of Cd2+ with the functional groups of O-H, C=O, -COO-, and C-O, as well as, cation-exchange with Mg2+ and K+. At initial Cd(II) ion concentration (C o), 50 mg/L, the adsorption equilibrium of 89...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29234892/how-accurate-is-the-description-of-ligand-protein-interactions-by-a-hybrid-qm-mm-approach
#16
Jakub Kollar, Vladimir Frecer
During the last decades, the application of hybrid quantum mechanical/molecular mechanical (QM/MM) methods has been extended to the field of drug design. In principle, the approximate QM/MM approach offers a more complete description of drug-receptor non-covalent interactions. This is especially true when charge or proton transfer, chelation of metal ions or strong polarization of ligand and protein or surface chemical groups are involved. The aim of this work was to assess the accuracy of calculated non-covalent ligand-protein interaction energies ([Formula: see text]) obtained by the hybrid QM/MM approach employed in QSite/Jaguar of Schrödinger's Small-Molecule Drug Discovery Suite on a set of small-molecule model systems when compared to rigorous QM calculations...
December 12, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29234403/response-surface-optimisation-for-the-production-of-antioxidant-hydrolysates-from-stone-fish-protein-using-bromelain
#17
Shehu Muhammad Auwal, Mohammad Zarei, Azizah Abdul-Hamid, Nazamid Saari
Protein hydrolysates produced from different food sources exhibit therapeutic potential and can be used in the management of chronic diseases. This study was targeted to optimise the conditions for the hydrolysis of stone fish protein to produce antioxidant hydrolysates using central composite design (CCD) by response surface methodology (RSM). The stone fish protein was hydrolysed under the optimum predicted conditions defined by pH (6.5), temperature (54°C), E/S ratio (1.5%), and hydrolysis time (360 min)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233652/synthesis-and-evaluation-of-a-class-of-1-4-7-triazacyclononane-derivatives-as-iron-depletion-antitumor-agents
#18
Sheng Wang, Yongkang Gai, Shasha Zhang, Lei Ke, Xiang Ma, Guangya Xiang
Iron depletion has been confirmed as an efficient strategy for cancer treatment. In the current study, a series of 1,4,7-triazacyclononane derivatives HE-NO2A, HP-NO2A and NE2P2A, as well as the bifunctional chelators p-NO2-PhPr-NE3TA and p-NH2-PhPr-NE3TA were synthesized and evaluated as iron-depleting agents for the potential anti-cancer therapy against human hepatocellular carcinoma. The cytotoxicity of these chelators was measured using hepatocellular cancer cells and compared with the clinically available iron depletion agent DFO and the universal metal chelator DTPA...
November 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29233039/characterization-antibacterial-total-antioxidant-scavenging-reducing-power-and-ion-chelating-activities-of-green-synthesized-silver-copper-and-titanium-dioxide-nanoparticles-using-artemisia-haussknechtii-leaf-extract
#19
Mehran Alavi, Naser Karimi
Recently, major problem related to pathogenic bacteria is augmentation of antibiotic resistance which has been changed treatment and recovery of millions of infectious patients. The present study reports an eco-friendly, rapid and easy method for synthesis of silver (Ag), copper (Cu) and titanium dioxide (TiO2) nanoparticles (NPs) using Artemisia haussknechtii leaf aqueous extract with antibacterial activities against multi-drug resistance (MDR) bacteria species. Three different concentrations (0.001, 0.01 and 0...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29233021/amitriptyline-modulated-ca2-signaling-and-induced-ca2-independent-cell-viability-in-human-osteosarcoma-cells
#20
T Lu, C-T Chou, W-Z Liang, C-C Kuo, I-L Chen, J-L Wang, C-R Jan
Amitriptyline is a widely used tricyclic antidepressant, which acts primarily as a serotonin-norepinephrine reuptake inhibitor. This study examined the effect of amitriptyline on Ca2+ homeostasis and its related mechanism in MG63 human osteosarcoma cells. Amitriptyline evoked cytosolic-free Ca2+ concentrations ([Ca2+]i) rises concentration dependently. Amitriptyline-evoked Ca2+ entry was confirmed by Mn2+-induced quench of fura-2 fluorescence. This entry was inhibited by Ca2+ entry modulators nifedipine, econazole, SKF96365, the protein kinase C (PKC) activator phorbol 12-myristate 13 acetate but was not affected by the PKC inhibitor GF109203X...
January 1, 2017: Human & Experimental Toxicology
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