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https://www.readbyqxmd.com/read/28647292/risk-factors-of-refeeding-syndrome-in-malnourished-older-hospitalized-patients
#1
Maryam Pourhassan, Ingeborg Cuvelier, Ilse Gehrke, Christian Marburger, Mirja Katrin Modreker, Dorothee Volkert, Hans-Peter Willschrei, Rainer Wirth
BACKGROUND & AIMS: Despite the high prevalence of malnutrition among older hospitalized persons, it is unknown how many of these malnourished patients are at risk of developing the refeeding syndrome (RFS). In this study, we sought to compare the prevalence and severity of malnutrition among older hospitalized patients with prevalence of known risk factors of RFS. METHODS: This cross-sectional multicenter-study investigated older participants who were consecutively admitted to the geriatric acute care ward...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28646979/inhibition-of-rapid-delayed-rectifier-potassium-current-ikr-by-ischemia-reperfusion-and-its-recovery-by-vitamin-e-in-ventricular-myocytes
#2
Yaoxu Chen, Chunxia Yin, Yingying Yang, Zhuo Fan, Jinling Shang, Wen Tan
Ischemia/reperfusion (I/R) induces prolongation of QT interval and action potential duration (APD), which is a major cardiac electrical disorder in patients with arrhythmias. However, the mechanism of QT interval prolongation induced by I/R remains unclear. In the present study, we hypothesized that the rapid component of delayed rectifier potassium (IKr) channel plays an important role in I/R-induced QT interval prolongation. We observed a marked attenuation of IKr and a significant prolongation of action potential duration (APD) in a simulated I/R system with sodium dithionite (Na2S2O4) in ventricular myocytes of guinea pigs...
July 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28646831/assessment-of-differences-in-nutrients-consumption-in-women-diagnosed-with-osteoporosis-as-compared-to-a-healthy-control-group
#3
Agata Wawrzyniak, Patrycja Klimczyk, Agnieszka Woźniak, Anna Anyżewska, Magdalena Leonkiewicz
Background: Osteoporosis is a condition that has been much more frequent for women, which is related to menopause and to their lower bone mineral density (BMD). Inappropriate diet is among the development factors of the disease. Objective: To assess differences in consumption of particular nutrients among women with and without osteoporosis diagnosed. Material and Methods: The study was conducted in 2013 in a group of 100 women aged 51-70, using a questionnaire, including a 24-hour recall related to a participant’s nutrients consumptions...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28646309/influence-of-polymethyl-acrylate-additive-on-the-formation-of-particulate-matter-and-nox-emission-of-a-biodiesel-diesel-fueled-engine
#4
Islam Mohammad Monirul, Haji Hassan Masjuki, Mohammad Abdul Kalam, Nurin Wahidah Mohd Zulkifli, Islam Shancita
The aim of this study is to investigate the effect of the polymethyl acrylate (PMA) additive on the formation of particulate matter (PM) and nitrogen oxide (NOX) emission from a diesel coconut and/or Calophyllum inophyllum biodiesel-fueled engine. The physicochemical properties of 20% of coconut and/or C. inophyllum biodiesel-diesel blend (B20), 0.03 wt% of PMA with B20 (B20P), and diesel fuel were measured and compared to ASTM D6751, D7467, and EN 14214 standard. The test results showed that the addition of PMA additive with B20 significantly improves the cold-flow properties such as pour point (PP), cloud point (CP), and cold filter plugging point (CFPP)...
June 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28642118/current-state-of-the-art-for-cardiac-arrhythmia-gene-therapy
#5
REVIEW
J Kevin Donahue
Cardiac arrhythmias are a leading cause of morbidity and mortality. Currently available therapeutic options lack sufficient efficacy and safety. Gene therapy has been proposed for treatment of cardiac arrhythmias. This review will discuss the current state of development for arrhythmia gene therapy. So far, all published studies are short-term, proof-of-concept animal studies. Potential replacement of cardiac pacemakers has been shown for combination gene therapy using the HCN2 gene and either the gene for adenylate cyclase, the skeletal muscle isoform of the sodium channel, or a dominant negative mutant of the potassium channel responsible for resting membrane potential...
June 19, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28641963/modulation-of-the-heart-s-electrical-properties-by-the-anticonvulsant-drug-retigabine
#6
Lena Rubi, Michael Kovar, Eva Zebedin-Brandl, Xaver Koenig, Manuel Dominguez-Rodriguez, Hannes Todt, Helmut Kubista, Stefan Boehm, Karlheinz Hilber
Retigabine, currently used as antiepileptic drug, has a wide range of potential medical uses. Administration of the drug in patients can lead to QT interval prolongation in the electrocardiogram and to cardiac arrhythmias in rare cases. This suggests that the drug may perturb the electrical properties of the heart, and the underlying mechanisms were investigated here. Effects of retigabine on currents through human cardiac ion channels, heterologously expressed in tsA-201 cells, were studied in whole-cell patch-clamp experiments...
June 19, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28641222/theoretical-evaluation-on-selective-adsorption-characteristics-of-alkali-metal-based-sorbents-for-gaseous-oxidized-mercury
#7
Hongjian Tang, Yufeng Duan, Chun Zhu, Tianyi Cai, Chunfeng Li, Liang Cai
Alkali metal-based sorbents are potential for oxidized mercury (Hg(2+)) selective adsorption but show hardly effect to elemental mercury (Hg(0)) in flue gas. Density functional theory (DFT) was employed to investigate the Hg(0) and HgCl2 adsorption mechanism over alkali metal-based sorbents, including calcium oxide (CaO), magnesium oxide (MgO), potassium chloride (KCl) and sodium chloride (NaCl). Hg(0) was found to weakly interact with CaO (001), MgO (001), KCl (001) and NaCl (001) surfaces while HgCl2 was effectively adsorbed on top-O and top-Cl sites...
June 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28637815/the-pro-inflammatory-cytokine-tumor-necrosis-factor-alpha-excites-subfornical-organ-neurons
#8
Nick James Simpson, Alastair V Ferguson
Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine implicated in cardiovascular and autonomic regulation via actions in the central nervous system. TNFα(-/-) mice do not develop angiotensin II (ANG II)-induced hypertension, and administration of TNFα into the bloodstream of rats increases blood pressure and sympathetic tone. Recent studies have shown that lesion of the subfornical organ (SFO) attenuates the hypertensive and autonomic effects of TNFα, while direct administration of TNFα into the SFO increases blood pressure, suggesting the SFO to be a key site for the actions of TNFα...
June 21, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28637420/bioinformatics-insights-on-targets-receptors-of-amiodarone-in-human-and-acanthamoeba-castellanii
#9
Abdul Baig, Zohaib Rana, H R Ahmad
BACKGROUND: Amiodarone is prescribed for certain cardiac arrhythmias in medical practice. The drug targets and inhibits voltage dependent sodium (Na+v), calcium (Ca+2v), potassium (K+v) channels, and enzymes like cytochrome P450 and oxidosqualene cyclase. Past studies have shown that amiodarone exerts anti-amoebic effects against Trypanosoma cruzi and Acanthamoeba castellanii. OBJECTIVES: The presence of aforementioned targets and the type of cell death induced by amiodarone in these pathogenic eukaryotes like Acanthamoeba castellanii remain to be verified...
June 21, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28634454/the-structure-and-function-of-the-na-k-atpase-isoforms-in-health-and-disease
#10
REVIEW
Michael V Clausen, Florian Hilbers, Hanne Poulsen
The sodium and potassium gradients across the plasma membrane are used by animal cells for numerous processes, and the range of demands requires that the responsible ion pump, the Na,K-ATPase, can be fine-tuned to the different cellular needs. Therefore, several isoforms are expressed of each of the three subunits that make a Na,K-ATPase, the alpha, beta and FXYD subunits. This review summarizes the various roles and expression patterns of the Na,K-ATPase subunit isoforms and maps the sequence variations to compare the differences structurally...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28633415/response-to-invitation-to-submit-a-reply-to-commentaryaje-00463-2017-can-estimation-of-sodium-intake-be-improved-by-borrowing-information-from-other-variables-tied-to-aje-00876-2016-r4-biomarker-calibrated-sodium-and-potassium-intake-and-cardiovascular-disease
#11
https://www.readbyqxmd.com/read/28633392/can-estimation-of-sodium-intake-be-improved-by-borrowing-information-from-other-variables
#12
Lawrence J Appel, David R Jacobs
Estimation of dietary sodium intake is problematic. The most accurate measure is average sodium excretion from multiple 24 hour urine collections, but such an approach is impractical. Using data from the Women's Health Initiative, Prentice and colleagues assessed the relationship of calibrated estimates of sodium and potassium excretion with cardiovascular outcomes. The calibrated estimates are a function of self-reported sodium/potassium ratio from a food frequency questionnaire, age, body mass index, race, supplement use, smoking status, education, income, and aspirin use...
June 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28633342/biomarker-calibrated-sodium-and-potassium-intake-and-cardiovascular-disease-risk-among-postmenopausal-women
#13
Ross L Prentice, Ying Huang, Marian L Neuhouser, JoAnn E Manson, Yasmin Mossavar-Rahmani, Fridtjof Thomas, Lesley F Tinker, Matthew Allison, Karen C Johnson, Sylvia Wassertheil-Smoller, Arjun Seth, Jacques E Rossouw, James Shikany, Laura D Carbone, Lisa W Martin, Marcia L Stefanick, Bernhard Haring, Linda Van Horn
Studies of sodium and potassium intake and cardiovascular disease incidence often rely on self-reported dietary data. Here self-reported intakes from postmenopausal women at 40 participating U.S. clinical centers are calibrated using 24-hour urinary excretion measures in Women's Health Initiative cohorts, with follow-up over 1993-2010. Hypertension incidence related positively to (calibrated) sodium intake and to the ratio of sodium-to-potassium. The sodium-to-potassium ratio was associated with cardiovascular disease incidence during a 12-year average follow-up period...
June 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28633068/multi-electrode-system-for-measurement-of-transmembrane-ion-fluxes-through-living-epithelial-cells
#14
Mirosław Zając, Andrzej Lewenstam, Krzysztof Dolowy
Cystic Fibrosis (CF) is the most common fatal human genetic disease. It is caused by the defect in a single anion channel protein which affects ion and water transport across the epithelial tissue. A flat multi-electrode platform of diameter 12mm, allowing for measurement of four ions: sodium, potassium, hydrogen and chloride by exchangeable/replaceable ion-selective electrodes is described. The measurement is possible owing to the architecture of the platform which accommodates all the electrodes and inlets/outlets...
June 13, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28625323/assessment-of-sodium-and-potassium-intake-by-24%C3%A2-h-urinary-excretion-in-a-healthy-mexican-cohort
#15
Maite Vallejo, Eloisa Colín-Ramírez, Susana Rivera Mancía, Raúl Cartas Rosado, Magdalena Madero, Oscar Infante Vázquez, Jesús Vargas-Barrón
BACKGROUND AND AIMS: A high dietary sodium intake and a low potassium intake are associated with adverse cardiovascular health. Data on these nutrients consumption in Mexico is limited. The aim of this study was to assess sodium and potassium intake by 24 h urinary excretion in a clinically healthy Mexican population. We additionally explored their association with blood pressure. METHODS: 711 clinically healthy participants aged 20-50 years old recruited in the Tlalpan 2020 cohort from September 2014-December 2015, were included in this cross-sectional analysis...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28623618/endothelin-1-decreases-excitability-of-the-dorsal-root-ganglion-neurons-via-etb-receptor
#16
Nandkishor K Mule, Jitendra N Singh, Kunal U Shah, Anil Gulati, Shyam S Sharma
Endothelin-1 (ET-1) has been demonstrated to be a pro-nociceptive as well as an anti-nociceptive agent. However, underlying molecular mechanisms for these pain modulatory actions remain unclear. In the present study, we evaluated the ability of ET-1 to alter the nociceptor excitability using a patch clamp technique in acutely dissociated rat dorsal root ganglion (DRG) neurons. ET-1 produced an increase in threshold current to evoke an action potential (I threshold) and hyperpolarization of resting membrane potential (RMP) indicating decreased excitability of DRG neurons...
June 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28623022/heterogeneity-of-zeolite-combined-with-biochar-properties-as-a-function-of-sewage-sludge-composting-and-production-of-nutrient-rich-compost
#17
Mukesh Kumar Awasthi, Meijing Wang, Ashok Pandey, Hongyu Chen, Sanjeev Kumar Awasthi, Quan Wang, Xiuna Ren, Altaf Hussain Lahori, Dong-Sheng Li, Ronghua Li, Zengqiang Zhang
In the present study, biochar combined with a higher dosage of zeolite (Z) and biochar (B) alone were applied as additives for dewatered fresh sewage sludge (DFSS) composting using 130-L working volume lab-scale reactors. We first observed that the addition of a mixture of B and Z to DFSS equivalent to 12%B+10% (Z-1), 15% (Z-2) and 30% (Z-3) zeolite (dry weight basis) worked synergistically as an amendment and increased the composting efficiency compared with a treatment of 12%B alone amended and a control without any amendment...
June 13, 2017: Waste Management
https://www.readbyqxmd.com/read/28622115/ppar%C3%AE-2-c1431t-polymorphism-interacts-with-the-antiobesogenic-effects-of-kochujang-a-korean-fermented-soybean-based-red-pepper-paste-in-overweight-obese-subjects-a-12-week-double-blind-randomized-clinical-trial
#18
Yunkyoung Lee, Youn-Soo Cha, Yongsoon Park, Myoungsook Lee
Kochujang, a Korean fermented soybean-based red pepper paste, has been reported to have beneficial health effects. The aim of this study was to examine the antiobesity effects of Kochujang as a supplement in overweight/obese subjects according polymorphisms in the obesity-linked gene, peroxisome proliferator activator receptor γ (PPARγ2). Sixty overweight/obese subjects, who had body mass indexes (BMI, kg/m(2)) ≥23 or waist/hip ratios (WHR) ≥0.90 for males or ≥0.85 for females, were randomly assigned to either taking 32 g/day of placebo or Kochujang for 12 weeks...
June 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28621786/alkali-and-alkaline-earth-metal-salts-of-tetrazolone-structurally-interesting-and-excellently-thermostable
#19
Piao He, Le Wu, Jin-Ting Wu, Xin Yin, Michael Gozin, Jian-Guo Zhang
Tetrazolone (5-oxotetrazole) was synthesized by a moderate strategy through three steps (addition, cyclization and catalytic hydrogenation) avoiding the unstable intermediate diazonium, as reported during the previous preparation. Alkali and alkaline earth metal salts with lithium (1), sodium (2), potassium (3), rubidium (4) caesium (5), magnesium (6), calcium (7), strontium (8) and barium (9) were prepared and fully characterized using elemental analysis, IR and NMR spectroscopy, DSC and TG analysis. All metal salts were characterized via single-crystal X-ray diffraction...
June 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28620187/discovery-and-identification-of-o-o-diethyl-o-4-5-phenyl-4-5-dihydroisoxazol-3-yl-phenyl-phosphorothioate-xp-1408-as-a-novel-mode-of-action-of-organophosphorus-insecticides
#20
Zhigang Zeng, Ying Yan, Bingfeng Wang, Niu Liu, Hanhong Xu
Organophosphorus (OP) insecticides play an important role in pest control. Many OP insecticides have been removed from the market because of their high toxicity to humans. We designed and synthesized a new OP insecticide with the goal of providing a low cost, and less toxic insecticide. The mode of action of O, O-diethyl O-(4-(5-phenyl-4, 5-dihydroisoxazol-3-yl) phenyl) phosphorothioate (XP-1408) was studied in Drosophila melanogaster. Bioassays showed that XP-1408 at a concentration of 50 mg/L delayed larval development...
June 15, 2017: Scientific Reports
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