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Autoimmune diet

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https://www.readbyqxmd.com/read/29770221/risperidone-induced-type-2-diabetes-presenting-with-diabetic-ketoacidosis
#1
Clarissa Ern Hui Fang, Mohammed Faraz Rafey, Aine Cunningham, Sean F Dinneen, Francis M Finucane
A 28-year-old male presented with 2 days of vomiting and abdominal pain, preceded by 2 weeks of thirst, polyuria and polydipsia. He had recently started risperidone for obsessive-compulsive disorder. He reported a high dietary sugar intake and had a strong family history of type 2 diabetes mellitus (T2DM). On admission, he was tachycardic, tachypnoeic and drowsy with a Glasgow Coma Scale (GCS) of 10/15. We noted axillary acanthosis nigricans and obesity (BMI 33.2 kg/m2 ). Dipstick urinalysis showed ketonuria and glycosuria...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29755475/impact-of-a-3-months-vegetarian-diet-on-the-gut-microbiota-and-immune-repertoire
#2
Chenchen Zhang, Andrea Björkman, Kaiye Cai, Guilin Liu, Chunlin Wang, Yin Li, Huihua Xia, Lijun Sun, Karsten Kristiansen, Jun Wang, Jian Han, Lennart Hammarström, Qiang Pan-Hammarström
The dietary pattern can influence the immune system directly, but may also modulate it indirectly by regulating the gut microbiota. Here, we investigated the effect of a 3-months lacto-ovo-vegetarian diet on the diversity of gut microbiota and the immune system in healthy omnivorous volunteers, using high-throughput sequencing technologies. The short-term vegetarian diet did not have any major effect on the diversity of the immune system and the overall composition of the metagenome. The prevalence of bacterial genera/species with known beneficial effects on the intestine, including butyrate-producers and probiotic species and the balance of autoimmune-related variable genes/families were, however, altered in the short-term vegetarians...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29752728/a-retrospective-study-of-dermatitis-herpetiformis-from-an-immunobullous-disease-clinic-in-north-india
#3
Sanjeev Handa, Garima Dabas, Dipankar De, Rahul Mahajan, Debajyoti Chatterjee, Uma N Saika, Bishan D Radotra
BACKGROUND: Indian data on dermatitis herpetiformis (DH) is not available. The aim of this study was to investigate the demographic and clinicopathological characteristics of patients with DH and to study its association with other autoimmune diseases. METHODS: All data were collected from case record forms of patients registered in immunobullous disease clinic of our institute. The diagnosis was based on characteristic clinical and immuno/histopathological features...
May 11, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29752697/biofortification-of-safflower-an-oil-seed-crop-engineered-for-ala-targeting-better-sustainability-and-plant-based-omega-3-fatty-acids
#4
Arti Rani, Asha Panwar, Manjary Sathe, Karunakara Alageri Chandrashekhara, Anil Kush
Alpha-linolenic acid (ALA) deficiency and a skewed n6:n3 fatty acid ratio in the diet is a major explanation for the prevalence of cardiovascular diseases and inflammatory/autoimmune diseases. There is mounting evidence of the health benefits associated with omega-3 long chain polyunsaturated fatty acids (LC PUFA's). Although present in abundance in fish, a number of factors limit our consumption of fish based omega-3 PUFA's. To name a few, overexploitation of wild fish stocks has reduced their sustainability due to increased demand of aquaculture for fish oil and meal; the pollution of marine food webs has raised concerns over the ingestion of toxic substances such as heavy metals and dioxins; vegetarians do not consider fish-based sources for supplemental nutrition...
May 11, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29745347/febrile-infection-related-epilepsy-syndrome-fires-an-overview-of-treatment-and-recent-patents
#5
Kam Lun E Lun Hon, Alexander K C Leung, Alcy R Torres
BACKGROUND: New-onset refractory status epilepticus (NORSE) refers to a clinical presentation in a patient without active epilepsy or other existing relevant neurological disorder, with new onset of refractory status epilepticus in the absence of a clear acute or active structural, metabolic, or toxic cause. Febrile infection-related epilepsy syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 hours and 2 weeks prior to the onset of refractory status epilepticus, with or without fever at the onset of status epilepticus, and with no restriction to the age of the patient...
May 8, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29735574/management-of-type-1-diabetes-with-a-very-low-carbohydrate-diet
#6
Belinda S Lennerz, Anna Barton, Richard K Bernstein, R David Dikeman, Carrie Diulus, Sarah Hallberg, Erinn T Rhodes, Cara B Ebbeling, Eric C Westman, William S Yancy, David S Ludwig
OBJECTIVES: To evaluate glycemic control among children and adults with type 1 diabetes mellitus (T1DM) who consume a very low-carbohydrate diet (VLCD). METHODS: We conducted an online survey of an international social media group for people with T1DM who follow a VLCD. Respondents included adults and parents of children with T1DM. We assessed current hemoglobin A1c (HbA1c) (primary measure), change in HbA1c after the self-reported beginning of the VLCD, total daily insulin dose, and adverse events...
May 7, 2018: Pediatrics
https://www.readbyqxmd.com/read/29730972/the-protective-effect-of-extra-virgin-olive-oil-in-the-experimental-model-of-multiple-sclerosis-in-the-rat
#7
C Conde, B M Escribano, E Luque, M Aguilar-Luque, M Feijóo, J J Ochoa, M LaTorre, A I Giraldo, R Lillo, E Agüera, A Santamaría, I Túnez
This study has evaluated the effect of EVOO (Extra-Virgin olive oil), OA (oleic acid) and HT (hydroxytyrosol) in an induced model of MS through experimental autoimmune encephalomyelitis (EAE). Dark Agouti 2-month old rats (25 males) were divided into five groups: (i) control group, (ii) EAE group, (iii) EAE+EVOO, (iv) EAE+HT, and (v) EAE+OA. At 65 days, the animals were sacrificed and the glutathione redox system and bacterial lipopolysaccharide (LPS) and LPS-binding protein (LBP) products of the microbiota in brain, spinal cord, and blood were evaluated...
May 5, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29708596/knock-out-of-the-gsta4-gene-in-male-mice-leads-to-an-altered-pattern-of-hepatic-protein-carbonylation-and-enhanced-inflammation-following-chronic-consumption-of-an-ethanol-diet
#8
Colin T Shearn, Casey F Pulliam, Kim Pedersen, Kyle Meredith, Kelly E Mercer, Laura M Saba, David J Orlicky, Martin J Ronis, Dennis R Petersen
BACKGROUND: Glutathione-S-transferase A4-4 (GSTA4) is a key enzyme for removal of toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE). In the current study, we examined the potential role of GSTA4 on protein carbonylation and progression of alcoholic liver disease (ALD) by examining the development of liver injury in male wild type SV/J mice (WT) and SV/J mice lacking functional GSTA4 (GSTA4-/- mice). METHODS: Adult male WT and GSTA4-/- mice were fed chow (N = 10-12) or high fat Lieber-DeCarli liquid diets containing up to 28% calories as ethanol (EtOH) (N = 18-20) for 116 days...
April 30, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29704914/celiac-disease-and-non-celiac-gluten-or-wheat-sensitivity-and-health-in-later-life-a-review
#9
REVIEW
Eirini Bathrellou, Meropi D Kontogianni, Demosthenes B Panagiotakos
Celiac disease (CD) and non-gluten (or wheat) sensitivity (NCGS) are two gluten-related disorders, the treatment of which relies on dietary withdrawal of gluten (absolute and lifelong in the case of CD patients). However, these conditions differ in their pathophysiology and impact on health. CD is an autoimmune disorder of the intestine, and is associated with a wide range of disorders, pre- and post-diagnosis. Its autoimmune and inflammatory nature raises concerns about its potential effects on mortality and morbidity...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29690884/capsaicin-enriched-diet-ameliorates-autoimmune-neuritis-in-rats
#10
Jeremias Motte, Björn Ambrosius, Thomas Grüter, Hussein Bachir, Melissa Sgodzai, Xiomara Pedreiturria, Kalliopi Pitarokoili, Ralf Gold
BACKGROUND: Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence and dietary components are known to affect the course of autoimmune diseases. Capsaicin as pungent component of chili-peppers is common in human nutrition. An influence of capsaicin on autoimmune diseases has been postulated. METHODS: We tested capsaicin in the animal model of experimental autoimmune neuritis (EAN) in Lewis rat. Rats were immunized with P2-peptide and were treated with capsaicin in different preventive settings...
April 24, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29670252/urbanization-and-the-gut-microbiota-in-health-and-inflammatory-bowel-disease
#11
REVIEW
Tao Zuo, Michael A Kamm, Jean-Frédéric Colombel, Siew C Ng
In the 21st century, urbanization represents a major demographic shift in developed and developing countries. Rapid urbanization in the developing world has been associated with an increasing incidence of several autoimmune diseases, including IBD. Patients with IBD exhibit a decrease in the diversity and richness of the gut microbiota, while urbanization attenuates the gut microbial diversity and might have a role in the pathogenesis of IBD. Environmental exposures during urbanization, including Westernization of diet, increased antibiotic use, pollution, improved hygiene status and early-life microbial exposure, have been shown to affect the gut microbiota...
April 18, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29669783/vasoactive-intestinal-peptide-ameliorates-acute-myocarditis-and-atherosclerosis-by-regulating-inflammatory-and-autoimmune-responses
#12
Raquel Benitez, Virginia Delgado-Maroto, Marta Caro, Irene Forte-Lago, Mario Duran-Prado, Francisco O'Valle, Andrew H Lichtman, Elena Gonzalez-Rey, Mario Delgado
Vasoactive intestinal peptide (VIP) is a neuropeptide that exerts various vascular and cardioprotective functions and regulates immune function and inflammatory response at multiple levels. However, its role in inflammatory cardiovascular disorders is largely unknown. Myocarditis and atherosclerosis are two inflammatory and autoimmune cardiovascular diseases that cause important adverse circulatory events. In this study, we investigate the therapeutic effects of VIP in various well-established preclinical models of experimental autoimmune myocarditis and atherosclerosis...
April 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29669109/opposing-actions-of-developmental-trichloroethylene-and-high-fat-diet-co-exposure-on-markers-of-lipogenesis-and-inflammation-in-autoimmune-prone-mice
#13
Sarah J Blossom, Lorenzo Fernandes, Shasha Bai, Sangeeta Khare, Kuppan Gokulan, Youzhong Yuan, Michael Dewall, Frank A Simmen, Kathleen M Gilbert
Trichloroethylene (TCE) is a widespread environmental pollutant associated with immunotoxicity and autoimmune disease. Previous studies showed that mice exposed from gestation through early life demonstrated CD4+ T cell alterations and autoimmune hepatitis. Determining the role of one environmental risk factor for any disease is complicated by the presence of other stressors. Based on its known effects, we hypothesized that developmental overnutrition in the form of a moderately high fat diet (HFD) consisting of 40% kcal fat would exacerbate the immunotoxicity and autoimmune-promoting effects of low-level (<10 μg/kg/day) TCE in autoimmune-prone MRL+/+ mice over either stressor alone...
April 12, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29664459/multiple-sclerosis-and-myasthenia-gravis-following-severe-weight-loss
#14
Mohammed H Alanazy, Majed A Alomar, Bandar N Aljafen, Taim A Muayqil
Weight loss has substantial health benefits, but it is not risk-free. Various neurological disorders have been reported following bariatric surgery-induced weight loss. Here, we report 3 patients who developed multiple sclerosis (MS), one of whom also developed myasthenia gravis (MG), shortly after significant weight loss. Two patients lost weight by following a diet plan and one underwent bariatric surgery. There may be an association between significant weight loss and the development of an autoimmune neurological disorder such as MS or MG; a high index of suspicion is required...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29660305/temporomandibular-joint-reconstruction-in-patients-with-autoimmune-connective-tissue-disease
#15
Pushkar Mehra, Charles H Henry, Kamyar R Giglou
PURPOSE: To evaluate clinical outcomes in patients with autoimmune or connective tissue (CT) disease undergoing temporomandibular joint (TMJ) reconstruction. MATERIALS AND METHODS: Patients were divided into 2 groups based on type of TMJ reconstruction. Patients in group 1 (n = 9) underwent autogenous reconstruction and had a diagnosis of rheumatoid arthritis (5), lupus arthritis (1), and psoriatic arthritis (3). Patients in group 2 (n = 2l) had alloplastic reconstruction with a patient-fitted total joint prosthesis (TMJ Concepts, Ventura, CA) and had a diagnosis of rheumatoid arthritis (15), lupus (3), and psoriatic arthritis (3)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29649575/the-interaction-between-environmental-triggers-and-epigenetics-in-autoimmunity
#16
Bruce Richardson
Systemic lupus erythematosus flares when genetically predisposed people encounter environmental agents that cause oxidative stress, such as infections and sunlight. How these modify the immune system to initiate flares is unclear. Drug induced lupus models demonstrate that CD4+ T cells epigenetically altered with DNA methylation inhibitors cause lupus in animal models, and similar T cells are found in patients with active lupus. How infections and sun exposure inhibit T cell DNA methylation is unclear. DNA methylation patterns are replicated each time a cell divides in a process that requires DNA methyltransferase one (Dnmt1), which is upregulated as cells enter mitosis, as well as the methyl donor S-adenosylmethionine, created from dietary sources...
April 9, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29627063/high-fiber-dietary-and-sodium-butyrate-attenuate-experimental-autoimmune-hepatitis-through-regulation-of-immune-regulatory-cells-and-intestinal-barrier
#17
En-De Hu, Da-Zhi Chen, Jin-Lu Wu, Feng-Bin Lu, Lu Chen, Ming-Hua Zheng, Hui Li, Yu Huang, Ji Li, Xiao-Ya Jin, Yue-Wen Gong, Zhuo Lin, Xiao-Dong Wang, Lan-Man Xu, Yong-Ping Chen
Autoimmune hepatitis (AIH) is chronic autoimmune liver disease accompanied with the imbalance of Treg/Th17 and increased intestinal permeability. We investigated the effects of a high fiber diet and sodium butyrate on the Treg/Th17 and intestinal barrier function in an experimental autoimmune hepatitis. Intraperitoneal injection of hepatic antigen (S100) was used to induce experimental autoimmune hepatitis mice model and mice were divided into normal control, S100 model control, S100 plus high fiber diet and S100 plus sodium butyrate...
March 22, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29626026/dilated-cardiomyopathy-as-the-first-presentation-of-coeliac-disease-association-or-causation
#18
Peysh Patel, Fraser Smith, Niamh Kilcullen, Nigel Artis
Global ventricular impairment is a frequent presentation in clinical practice, but dissection of causative mechanisms from clinical associations is challenging. We present the case of a 19-year-old man who presented with dilated cardiomyopathy as the first presentation of coeliac disease. The manifestation of iron deficiency anaemia prompted gastroenterology input and enabled accurate diagnosis. It is unclear whether coeliac disease was simply coexistent or directly implicated in pathophysiology. Mechanisms may relate to nutritional deficiencies or autoimmune myocarditis arising from cross-reactivity...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29620596/celiac-disease-30-years-after-diagnosis-struggling-with-gluten-free-adherence-or-gaining-gluten-tolerance
#19
Lorenzo Norsa, Federica Branchi, Marianna Bravo, Francesca Ferretti, Leda Roncoroni, Francesco Somalvico, Dario Conte, Maria Teresa Bardella, Sabrina Fabiano, Giulio Barigelletti, Luca Elli
OBJECTIVES: Studies investigating patients with coeliac disease (CD) on very long-term follow-up are limited. We aimed to evaluate the characteristics of patients with CD diagnosed more than 30 years ago. METHODS: Clinical, histologic, genetic and demographic data of patients with CD diagnosis made before 1985 were collected and their standardised mortality ratio (SMR) calculated. According to the gluten free diet (GFD) status, CD patients were divided into three groups and a specific questionnaire on GFD awareness and gluten-free products was administered to patients and caregivers...
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29618473/il-23r-deficiency-does-not-impact-atherosclerotic-plaque-development-in-mice
#20
Daniel Engelbertsen, Marie A C Depuydt, Robin A F Verwilligen, Sara Rattik, Erik Levinsohn, Andreas Edsfeldt, Felicia Kuperwaser, Petr Jarolim, Andrew H Lichtman
BACKGROUND: Interleukin-23 (IL-23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL-23 receptor (IL-23R)-expressing cells in the atherosclerotic aorta and evaluated the effect of IL-23R deficiency on atherosclerosis development in mice. METHODS AND RESULTS: We used heterozygous Ldlr -/- Il23r e GFP / WT knock-in mice to identify IL-23R-expressing cells by flow cytometry and homozygous Ldlr -/- Il23r e GFP / eGFP ( Ldlr -/- Il23r -/- ) mice to investigate the effect of lack of IL-23R in atherosclerosis...
April 4, 2018: Journal of the American Heart Association
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