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Autoimmune diet

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https://www.readbyqxmd.com/read/29348821/glycan-microarray-reveal-induced-iggs-repertoire-shift-against-a-dietary-carbohydrate-in-response-to-rabbit-anti-human-thymocyte-therapy
#1
Ron Amon, Shani Leviatan Ben-Arye, Limor Engler, Hai Yu, Noha Lim, Ludmilla Le Berre, Kristina M Harris, Mario R Ehlers, Stephen E Gitelman, Xi Chen, Jean-Paul Soulillou, Vered Padler-Karavani
Humans have circulating antibodies against diverse glycans containing N-glycolylneuraminic acid (Neu5Gc) due to function-loss mutation of the CMAH gene. This xenogenic non-human carbohydrate is abundant in red meat, xenografts and biotherapeutics. Low levels of diet-derived Neu5Gc is also present on normal human endothelial cells, and together with anti-Neu5Gc antibodies could potentially mediate "xenosialitis" chronic-inflammation. Rabbit anti-human thymocyte globulin (ATG) is a drug containing polyclonal IgG glycoproteins commonly used as an immunosuppressant in human transplantation and autoimmune diseases...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29343517/early-infant-diet-and-islet-autoimmunity-in-the-teddy-study
#2
Ulla Uusitalo, Hye-Seung Lee, Carin Andrén Aronsson, Kendra Vehik, Jimin Yang, Sandra Hummel, Katherine Silvis, Åke Lernmark, Marian Rewers, William Hagopian, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey Krischer, Suvi M Virtanen, Jill M Norris
OBJECTIVE: To examine duration of breastfeeding and timing of complementary foods and risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS: The TEDDY study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes (T1D) in the U.S., Finland, Germany, and Sweden. This study included 7,563 children with at least 9 months of follow-up. Blood samples were collected every 3 months from birth to evaluate IA, defined as persistent, confirmed positive insulin autoantibodies (IAAs), glutamic acid decarboxylase, or insulinoma antigen-2...
January 17, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29343438/regulation-of-the-immune-response-by-the-aryl-hydrocarbon-receptor
#3
REVIEW
Cristina Gutiérrez-Vázquez, Francisco J Quintana
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is activated by small molecules provided by the diet, microorganisms, metabolism, and pollutants. AhR is expressed by a number of immune cells, and thus AhR signaling provides a molecular pathway that integrates the effects of the environment and metabolism on the immune response. Studies have shown that AhR signaling plays important roles in the immune system in health and disease. As its activity is regulated by small molecules, AhR also constitutes a potential target for therapeutic immunomodulation...
January 16, 2018: Immunity
https://www.readbyqxmd.com/read/29316320/human-microbiota-blood-group-antigens-and-disease
#4
REVIEW
D Rose Ewald, Susan C J Sumner
Far from being just "bugs in our guts," the microbiota interacts with the body in previously unimagined ways. Research into the genome and the microbiome has revealed that the human body and the microbiota have a long-established but only recently recognized symbiotic relationship; homeostatic balance between them regulates body function. That balance is fragile, easily disturbed, and plays a fundamental role in human health-our very survival depends on the healthy functioning of these microorganisms. Increasing rates of cardiovascular, autoimmune, and inflammatory diseases, as well as epidemics in obesity and diabetes in recent decades are believed to be explained, in part, by unintended effects on the microbiota from vaccinations, poor diets, environmental chemicals, indiscriminate antibiotic use, and "germophobia...
January 9, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29311129/regulatory-t-cells-from-discovery-to-autoimmunity
#5
Alexandra Kitz, Emily Singer, David Hafler
Multiple sclerosis (MS) is a genetically mediated autoimmune disease of the central nervous system. Allelic variants lead to lower thresholds of T-cell activation resulting in activation of autoreactive T cells. Environmental factors, including, among others, diet, vitamin D, and smoking, in combination with genetic predispositions, play a substantial role in disease development and activation of autoreactive T cells. FoxP3+ regulatory T cells (Tregs) have emerged as central in the control of autoreactive T cells...
January 8, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29311119/the-role-of-the-gut-microbiome-in-systemic-inflammatory-disease
#6
REVIEW
Jose C Clemente, Julia Manasson, Jose U Scher
The role of the gut microbiome in models of inflammatory and autoimmune disease is now well characterized. Renewed interest in the human microbiome and its metabolites, as well as notable advances in host mucosal immunology, has opened multiple avenues of research to potentially modulate inflammatory responses. The complexity and interdependence of these diet-microbe-metabolite-host interactions are rapidly being unraveled. Importantly, most of the progress in the field comes from new knowledge about the functional properties of these microorganisms in physiology and their effect in mucosal immunity and distal inflammation...
January 8, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29307296/dietary-fatty-acids-and-susceptibility-to-multiple-sclerosis
#7
Stefanie Haase, Aiden Haghikia, Ralf Gold, Ralf A Linker
BACKGROUND: The gut microbiome as well as dietary habits have recently been established as environmental contributors to the pathogenesis of multiple sclerosis (MS), a T-cell-mediated autoimmune disease of the central nervous system (CNS). OBJECTIVE: To summarize recent findings on the Janus-faced effects of dietary short-chain fatty acids (SCFAs) and long-chain fatty acids (LCFAs) on T-cell immunity with a special focus on the gut and the microbiome as an interface linking diet and T-cell responses during MS...
January 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29302503/celiac-disease-in-south-jordan
#8
Eyad Altamimi
Purpose: Celiac disease, an autoimmune enteropathy triggered by exposure to gluten, is not uncommon in South Jordan. However, its prevalence is underestimated due to lack of physician awareness of the diversity of disease presentation. The clinical spectrum includes classic gastrointestinal manifestations, as well as rickets, iron-deficiency anemia, short stature, elevated liver enzymes, and edema. Our goal was to evaluate celiac disease presentation in clinically diagnosed children. Methods: Retrospective study included all children diagnosed with celiac disease between September 2009 and September 2015...
December 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29287009/adherence-to-the-gluten-free-diet-and-health-related-quality-of-life-in-an-ethnically-diverse-pediatric-population-with-celiac-disease
#9
Diana Mager, Margaret Marcon, Herbert Brill, Amanda Liu, Kristin Radmanovich, Heather Mileski, Roseann Nasser, Abeer Alzaben, Matthew W Carroll, Jason Yap, Rabin Persad, Justine M Turner
OBJECTIVES: Celiac disease (CD) is an autoimmune disease that requires life-long adherence to a gluten-free diet (GFD). Adherence to the GFD in childhood may be poor and adversely influence health related quality of life (HRQOL). The study purpose was to determine socio-demographic and socio-economic factors influencing adherence to the GFD and HRQOL in a multi-ethnic cohort of youth with CD. METHODS: A multi-site (Edmonton, Hamilton, Toronto) study examining child-parent HRQOL in youth with CD (n=243) and /or mild gastrointestinal complaints (GI-CON; n = 148) was conducted...
January 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29274967/milk-basic-protein-supplementation-exerts-an-anti-inflammatory-effect-in-a-food-allergic-enteropathy-model-mouse
#10
Aiko Ono-Ohmachi, Haruyo Nakajima-Adachi, Yoshikazu Morita, Ken Kato, Satoshi Hachimura
To examine novel functions of milk basic protein (MBP) in T-cell-related inflammatory diseases, such as autoimmune diseases and allergies, we evaluated the effects of MBP on the causative responses of ovalbumin (OVA)-specific T cells in a food-allergic enteropathy model, OVA23-3 mice, which express an OVA-specific T-cell receptor gene. The OVA-specific CD4+ T cells of the mesenteric lymph nodes (MLN) from OVA23-3 mice were cultured with CD11c+ dendritic cells of MLN from BALB/cA mice in the absence or presence of MBP following stimulation with OVA; then the levels of CD69 expression and the levels of cytokine production by CD4+ T cells were measured to evaluate activation...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29258769/calcium-and-vitamin-d-in-human-health-hype-or-real
#11
REVIEW
Sunil J Wimalawansa, DSc Mohammed S Razzaque, Nasser M Al-Daghri
The incidence and the prevalence of vitamin D deficiency are increasing worldwide. It is estimated that over 50% of population in the world have low in vitamin D (i.e., hypovitaminosis D; levels below 30 ng/mL). 80% of our vitamin D requirement comes from the ultraviolet rays from sunlight, and for the remainder, we rely from the diet and supplements. The latter become important when one is exposing to less than optimal amounts of sunlight, inability of the skin to generate vitamin D efficiently, and/or having secondary causes that leads to increase catabolism of vitamin D...
December 16, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29249178/biomarkers-of-cardiometabolic-health-and-nutritional-status-in-individuals-with-positive-celiac-disease-serology
#12
Joseph Jamnik, David Ja Jenkins, Ahmed El-Sohemy
BACKGROUND: Celiac disease (CD) is an autoimmune disorder characterized by damage to the intestinal mucosa and nutrient malabsorption in severe cases. However, it remains unclear whether nutrient deficiencies and other adverse health effects are prevalent in individuals with positive CD serology identified through screening studies. OBJECTIVE: The objective was to determine whether biomarkers of cardiometabolic health and nutritional status differ between those with positive and negative CD serology identified in a screening study of Canadian adults...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29230215/potential-effects-of-horizontal-gene-exchange-in-the-human-gut
#13
Aaron Lerner, Torsten Matthias, Rustam Aminov
Many essential functions of the human body are dependent on the symbiotic microbiota, which is present at especially high numbers and diversity in the gut. This intricate host-microbe relationship is a result of the long-term coevolution between the two. While the inheritance of mutational changes in the host evolution is almost exclusively vertical, the main mechanism of bacterial evolution is horizontal gene exchange. The gut conditions, with stable temperature, continuous food supply, constant physicochemical conditions, extremely high concentration of microbial cells and phages, and plenty of opportunities for conjugation on the surfaces of food particles and host tissues, represent one of the most favorable ecological niches for horizontal gene exchange...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29224093/sex-effects-at-the-ramparts-nutrient-and-microbe-mediated-regulation-of-the-immune-metabolic-interface
#14
Nyrie Israelian, Jayne S Danska
The relationships between dietary compounds, derivative metabolites, and host metabolism and immunity are controlled by diverse molecular mechanisms. Essential contributions to these dynamics come from the community of microbes (the microbiome) inhabiting the human digestive tract. The composition and function of the microbiome are shaped by available nutrients, and reciprocally, these organisms produce an as yet poorly defined repertoire of molecules that communicate with the epithelial barrier and the mucosal immune system...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29202198/adverse-effects-of-gluten-ingestion-and-advantages-of-gluten-withdrawal-in-nonceliac-autoimmune-disease
#15
Aaron Lerner, Yehuda Shoenfeld, Torsten Matthias
In light of the coincident surge in overall gluten intake and the incidence of autoimmune diseases, the possible biological adverse effects of gluten were explored. PubMed, MEDLINE, and the Cochrane Library databases were screened for reports published between 1964 and 2016 regarding the adverse effects of gluten as well as the effects of a gluten-free diet on autoimmune diseases. In vitro and in vivo studies describing gluten intake in animal models or cell lines and gluten-free diets in human autoimmune diseases were reviewed...
November 30, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29198905/the-microbiota-regulates-immunity-and-immunologic-diseases-in-dogs-and-cats
#16
REVIEW
Ian R Tizard, Sydney W Jones
The complex commensal microbiota found on body surfaces controls immune responses and the development of allergic and inflammatory diseases. New genetic technologies permit investigators to determine the composition of the complex microbial populations found on these surfaces. Changes in the microbiota (dysbiosis) as a result of antibiotic use, diet, or other factors thus influence the development of many diseases in the dog and cat. The most important of these include chronic gastrointestinal disease; respiratory allergies, such as asthma; skin diseases, especially atopic dermatitis; and some autoimmune diseases...
November 29, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29193293/functional-antagonism-of-sphingosine-1-phosphate-receptor-1-prevents-cuprizone-induced-demyelination
#17
SunJa Kim, Jacek Bielawski, Hyunmin Yang, Yu Kong, Beiyan Zhou, Jianrong Li
Recent evidence suggests that the oral drug Fingolimod (FTY720) for relapsing-remitting multiple sclerosis (MS) may act directly on the central nervous system (CNS) and modulate disease pathogenesis and progression in experimental models of MS. However, the specific subtype of sphingosine-1-phosphate (S1P) receptors that mediates the effect of FTY720 on the CNS cells has not been fully elucidated. Here, we report that S1P receptor 1 (S1PR1) is elevated in reactive astrocytes in an autoimmunity independent mouse model of MS and that selective S1PR1 modulation is sufficient to ameliorate the loss of oligodendrocytes and demyelination...
November 29, 2017: Glia
https://www.readbyqxmd.com/read/29191561/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-celiac-disease-safety-pharmacokinetics-and-effects-on-intestinal-histology-and-plasma-cytokines-with-escalating-dose-regimens-of-nexvax2-in-a-randomized-double-blind-placebo-controlled-phase-1
#18
A James M Daveson, Hooi C Ee, Jane M Andrews, Timothy King, Kaela E Goldstein, John L Dzuris, James A MacDougall, Leslie J Williams, Anita Treohan, Michael P Cooreman, Robert P Anderson
BACKGROUND: Nexvax2® is a novel, peptide-based, epitope-specific immunotherapy intended to be administered by regular injections at dose levels that increase the threshold for clinical reactivity to natural exposure to gluten and ultimately restore tolerance to gluten in patients with celiac disease. Celiac disease patients administered fixed intradermal doses of Nexvax2 become unresponsive to the HLA-DQ2·5-restricted gluten epitopes in Nexvax2, but gastrointestinal symptoms and cytokine release mimicking gluten exposure, that accompany the first dose, limit the maximum tolerated dose to 150μg...
November 22, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29172662/-maternal-and-neonatal-vitamin-b12-deficiency-detected-by-expanded-newborn-screening
#19
Ferenc Papp, Gábor Rácz, István Lénárt, Jenő Kóbor, Csaba Bereczki, Eszter Karg, Ákos Baráth
INTRODUCTION: Infant vitamin B12 deficiency can manifest as a severe neurodegenerative disorder and is usually caused by maternal deficiency due to vegetarian diet or pernicious anaemia. Its early recognition and treatment can prevent potentially serious and irreversible neurologic damage. Biochemically, vitamin B12 deficiency leads to an accumulation of methylmalonic acid, homocysteine, and propionylcarnitine. Expanded newborn screening using tandem mass spectrometry may identify neonatal and maternal vitamin B12 deficiency by measurement of propionylcarnitine and other metabolites in the dried blood spot sample of newborns...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29167795/managing-rheumatoid-arthritis-with-dietary-interventions
#20
REVIEW
Shweta Khanna, Kumar Sagar Jaiswal, Bhawna Gupta
Self-help by means of dietary interventions can help in management of various disorders including rheumatoid arthritis (RA), a debilitating autoimmune disease. Dietary interventions necessitate a widespread appeal for both patients as well as clinicians due to factors including affordability, accessibility, and presence of scientific evidences that demonstrate substantial benefits in reducing disease symptoms such as pain, joint stiffness, swelling, tenderness and associated disability with disease progression...
2017: Frontiers in Nutrition
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