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https://www.readbyqxmd.com/read/28437892/high-performance-and-low-cost-transparent-electrodes-based-on-ultrathin-cu-layer
#1
David Ebner, Martin Bauch, Theodoros Dimopoulos
Transparent electrodes based on an ultrathin Cu layer, embedded between two dielectrics, are optimized by simulations and experiments. Different dielectrics are screened in transfer matrix simulations for maximizing the broad-band transmittance. Based on this, sputtered electrodes were developed with the Cu embedded between TiO<sub>X</sub>-coated glass or PET substrate and an Al-doped ZnO (AZO) top layer. It is found that, for ultrathin Cu layers, increased sputter power fosters island coalescence, leading to superior optical and electrical performance compared to previously reported Cu-based electrodes...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437735/detective-quantum-efficiency-dqe-in-pet-scanners-a-simulation-study
#2
George E Karpetas, Christos M Michail, George P Fountos, Nektarios I Kalyvas, Ioannis G Valais, Ioannis S Kandarakis, George S Panayiotakis
The aim of the present study is to introduce the detective quantum efficiency (DQE) for the image quality assessment of positron emission tomography (PET) scanners. For this purpose, a thin layer chromatography (TLC) plane source was simulated using a previously validated, scanner and source geometry, Monte Carlo (MC) model. The model was developed with the Geant4 application for tomographic emission (GATE) MC package and reconstructed images obtained with the software for tomographic image reconstruction (STIR), with cluster computing...
April 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28437679/nodal-recurrence-after-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-incidence-and-proposed-risk-factors
#3
REVIEW
Krista C J Wink, Angela van Baardwijk, Esther G C Troost, Dirk De Ruysscher
Stereotactic body radiotherapy (SBRT) is an alternative to surgery for patients with early stage non-small cell lung cancer (NSCLC) who are inoperable due to comorbid disease or who refuse surgery. SBRT results in an excellent local control rate of more than 90%, which is comparable to surgery, while short and long-term overall toxicity is low. Surgically treated patients are often more extensively staged pre-operatively, e.g. with endobronchial ultrasound and/or mediastinoscopy, and typically undergo intra-operative lymph node dissection or sampling...
April 12, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28437565/relaxed-ordered-subset-preconditioned-alternating-projection-algorithm-for-pet-reconstruction-with-automated-penalty-weight-selection
#4
C Ross Schmidtlein, Yizun Lin, Si Li, Andrzej Krol, Bradley J Beattie, John L Humm, Yuesheng Xu
PURPOSE: Performance of the preconditioned alternating projection algorithm (PAPA) using relaxed ordered subsets (ROS) with a non-smooth penalty function was investigated in positron emission tomography (PET). A higher order total variation (HOTV) regularizer was applied and a method for unsupervised selection of penalty weights based on the measured data is introduced. METHODS: A ROS version of PAPA with HOTV penalty (ROS-HOTV-PAPA) for PET image reconstruction was developed and implemented...
April 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28437441/fluorescence-imaging-topography-scanning-system-for-intraoperative-multimodal-imaging
#5
Tri T Quang, Hye-Yeong Kim, Forrest Sheng Bao, Francis A Papay, W Barry Edwards, Yang Liu
Fluorescence imaging is a powerful technique with diverse applications in intraoperative settings. Visualization of three dimensional (3D) structures and depth assessment of lesions, however, are oftentimes limited in planar fluorescence imaging systems. In this study, a novel Fluorescence Imaging Topography Scanning (FITS) system has been developed, which offers color reflectance imaging, fluorescence imaging and surface topography scanning capabilities. The system is compact and portable, and thus suitable for deployment in the operating room without disturbing the surgical flow...
2017: PloS One
https://www.readbyqxmd.com/read/28436919/a-machine-learning-method-for-fast-and-accurate-characterization-of-depth-of-interaction-gamma-cameras
#6
Stefano Pedemonte, Larry Pierce, Koen Van Leemput
Measuring the depth-of-interaction (DOI) of gamma photons enables increasing the resolution of emission imaging systems. Several design variants of DOI-sensitive detectors have been recently introduced to improve the performance of scanners for Positron Emission Tomography (PET). However, the accurate characterization of the response of DOI detectors, necessary to accurately measure the DOI, remains an unsolved problem. Numerical simulations are, at the state of the art, imprecise, while measuring directly the characteristics of DOI detectors experimentally is hindered by the impossibility to impose the depth-of-interaction in an experimental set-up...
April 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28436851/synergistic-pet-and-sense-mr-image-reconstruction-using-joint-sparsity-regularization
#7
Abolfazl Mehranian, Martin Belzunce, Claudia Prieto, Alexander Hammers, Andrew Reader
In this work we propose a generalized joint sparsity regularization prior and reconstruction framework for the syner-gistic reconstruction of PET and undersampled sensitivity en-coded (SENSE) MRI data with the aim of improving image quality beyond that obtained through conventional independent recon-structions. The proposed prior improves upon the joint total vari-ation (TV) using a non-convex potential function that assigns a rel-atively lower penalty for the PET and MR gradients whose mag-nitudes are jointly large, thus permitting the preservation and for-mation of common boundaries irrespective of their relative orien-tation...
April 18, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28436339/cognitive-sequelae-of-lithium-intoxication-a-case-report
#8
Stefan Frisch, Frank Grünwald, Benedikt Friedrichs
Lithium intoxication is known to induce cognitive deficits along with motor and behavioral changes, even in association with normal serum levels. However, cases with comprehensive neuropsychological assessment of the deficits are rare. In our patient, we initially found severe cognitive deficits, including apraxia and visuo-constructive problems, and temporo-parietal FDG-PET hypometabolism. Neuropsychological and imaging findings were highly suggestive of Alzheimer's disease. However, lithium intoxication was suspected to account for these findings because of a Parkinson's syndrome, despite serum levels being in the upper therapeutic range...
April 24, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28436173/relationship-between-endobronchial-ultrasound-guided-ebus-transbronchial-needle-aspiration-utility-and-computed-tomography-staging-node-size-at-ebus-and-positron-emission-tomography-scan-node-standard-uptake-values-a-retrospective-analysis
#9
Clare Marchand, Andrew R L Medford
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) diagnoses and stages mediastinal lymph node pathology. This retrospective study determined the relationship between EBUS-TBNA utility and non-small cell lung cancer (NSCLC) stage, lymph node size, and positron emission tomography (PET) standard uptake values (SUV), and the utility of neck ultrasound in bulky mediastinal disease. METHODS: Data of 284 consecutive patients who had undergone EBUS-TBNA was collected...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28436063/placental-histology-findings-in-relation-to-pre-eclampsia-implications-for-interpretation-of-retrospective-studies
#10
Neil Sebire
In this issue Khalil et al. report the findings of a systematic review of studies reporting placental histological features in relation to pre-eclampsia (PET).(1) The main findings of this study were first, that whilst certain histological patterns were more common in PET than controls, similar features were also noted in unaffected cases, and secondly, that the results were related to whether the histological features in the studies were assessed blindly, with significantly greater apparent differences between groups reported in unblinded studies...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28435764/a-case-of-well-differentiated-papillary-mesothelioma-of-the-male-peritoneum-successful-treatment-by-systemic-chemotherapy
#11
Aziz Bazine, Mohamed Fetohi, Tariq Namad, Asmae Benzekri, Brahim Zainoun, Rachid Tanz, Mohamed Ichou
Well-differentiated papillary mesothelioma of the peritoneum (WDPMP) is a rare subtype of epithelioid mesothelioma, which is usually seen in young women without a history of asbestos exposure, and generally, has an indolent course. The relative rarity of this neoplasm in males prompted us to report this case of a well-differentiated papillary mesothelioma of the peritoneum in a 36-year-old man. The patient, who had no history of asbestos exposure, presented with abdominal pain and ascites of unknown etiology...
March 19, 2017: Curēus
https://www.readbyqxmd.com/read/28435529/-18-f-labeled-pyrido-3-4-d-pyrimidine-as-an-effective-probe-for-imaging-of-l858r-mutant-epidermal-growth-factor-receptor
#12
Hiroyuki Kimura, Haruka Okuda, Masumi Ishiguro, Kenji Arimitsu, Akira Makino, Ryuichi Nishii, Anna Miyazaki, Yusuke Yagi, Hiroyuki Watanabe, Ikuo Kawasaki, Masahiro Ono, Hideo Saji
In nonsmall-cell lung carcinoma patients, L858R mutation of epidermal growth factor receptor (EGFR) is often found, and molecular target therapy using EGFR tyrosine kinase inhibitors is effective for the patients. However, the treatment frequently develops drug resistance by secondary mutation, of which approximately 50% is T790M mutation. Therefore, the ability to predict whether EGFR will undergo secondary mutation is extremely important. We synthesized a novel radiofluorinated 4-(anilino)pyrido[3,4-d]pyrimidine derivative ([(18)F]APP-1) and evaluated its potential as a positron emission tomography (PET) imaging probe to discriminate the difference in mutations of tumors...
April 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28435455/the-netpet-score-combining-fdg-and-somatostatin-receptor-imaging-for-optimal-management-of-patients-with-metastatic-well-differentiated-neuroendocrine-tumors
#13
EDITORIAL
Elif Hindié
Neuroendocrine tumors (NET) are often metastatic at the time of diagnosis. Metastatic well-differentiated (G1/G2) NET may display a wide range of behaviors, ranging from indolent to aggressive, even within apparently homogeneous categories. Thus, selecting the optimal treatment strategy is a challenging task. Somatostatin receptor imaging (SRI) is the standard molecular imaging technique for well-differentiated NET. When performed with (68)Ga-labeled somatostatin analogs (SRI-PET), it offers exquisite sensitivity for disease staging...
2017: Theranostics
https://www.readbyqxmd.com/read/28435454/dual-somatostatin-receptor-fdg-pet-ct-imaging-in-metastatic-neuroendocrine-tumours-proposal-for-a-novel-grading-scheme-with-prognostic-significance
#14
David Lh Chan, Nick Pavlakis, Geoffrey P Schembri, Elizabeth J Bernard, Edward Hsiao, Aimee Hayes, Tristan Barnes, Connie Diakos, Mustafa Khasraw, Jaswinder Samra, Enid Eslick, Paul J Roach, Alexander Engel, Stephen J Clarke, Dale L Bailey
Background: PET scans using FDG and somatostatin receptor imaging agents have both been used to study neuroendocrine tumours. Most reports have documented the sensitivity and specificity of each radiopharmaceutical independently, and even suggested the superiority of one over the other for different grades of disease. Aim: The aim of this work was to develop a grading scheme that describes the joint results of both the FDG and somatostatin receptor imaging PET scans in staging subjects with neuroendocrine tumours in a single combined parameter...
2017: Theranostics
https://www.readbyqxmd.com/read/28435196/hemato-biochemical-alterations-and-urinalysis-in-dogs-suffering-from-benign-prostatic-hyperplasia
#15
M R Das, R C Patra, R K Das, P K Rath, B P Mishra
AIM: The study was designed to evaluate the hemato-biochemical alterations, urinalysis along with histomorphological and histological changes of prostate glands in dogs affected with benign prostatic hyperplasia (BPH) in and around Bhubaneswar, Odisha, India. MATERIALS AND METHODS: In toto, 445 dogs presented to the Teaching Veterinary Clinical Complex of the College of Veterinary Sciences and Animal Husbandry, one Government Veterinary Hospital and two pet clinics in and around Bhubaneswar screened for the presence of BPH...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28435146/prognostic-analysis-of-absolute-lymphocyte-and-monocyte-counts-after-autologous-stem-cell-transplant-in-children-adolescents-and-young-adults-with-refractory-or-relapsed-hodgkin-s-lymphoma
#16
Jorge Galvez Silva, Ossama M Maher, Minjeong Park, Diane Liu, Fiorela Hernandez, Priti Tewari, Yago Nieto
Previous studies in adults have shown that peripheral blood absolute lymphocyte and monocyte count ratio (ALC/AMC) after autologous stem cell transplant (ASCT) can predict outcome in patients with relapsed/refractory Hodgkin's lymphoma (R/R HL). We retrospectively reviewed all of our children, adolescent, and young adult (CAYA) patients (age ≤26) transplanted for R/R HL between 2004 and 2015. Seventy-six patients (median age 21, range 10-26 years) who reached d100 (d100) disease free were analyzed; 33% of them had PET-positive tumors prior to ASCT...
April 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28434874/unusual-isolated-pelvic-metastasis-from-a-clear-cell-hepatocellular-carcinoma-demonstrated-on-18-f-fdg-pet-ct-after-liver-transplantation
#17
R Zhang, J Tan, G Zhang, R Wang, Q Jia
No abstract text is available yet for this article.
April 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28434798/prognostic-value-of-dynamic-hypoxia-pet-in-head-and-neck-cancer-results-from-a-planned-interim-analysis-of-a-randomized-phase-ii-hypoxia-image-guided-dose-escalation-trial
#18
Stefan Welz, David Mönnich, Christina Pfannenberg, Konstantin Nikolaou, Mathias Reimold, Christian La Fougère, Gerald Reischl, Paul-Stefan Mauz, Frank Paulsen, Markus Alber, Claus Belka, Daniel Zips, Daniela Thorwarth
BACKGROUND AND PURPOSE: To prospectively assess the prognostic value of tumour hypoxia determined by dynamic [(18)F]Fluoromisonidazole (dynFMISO) PET/CT, and to evaluate both feasibility and toxicity in patients with locally advanced squamous cell carcinomas of the head and neck (LASCCHN) treated with dynFMISO image-guided dose escalation (DE) using dose-painting by contours. PATIENTS AND METHODS: We present a planned interim analysis of a randomized phase II trial...
April 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28434797/patterns-of-care-survey-radiotherapy-for-women-with-locally-advanced-cervical-cancer
#19
Peter de Boer, Ina M Jürgenliemk-Schulz, Henrike Westerveld, Astrid A C de Leeuw, Raquel Dávila-Fajardo, Coen R N Rasch, Bradley R Pieters, Lukas J A Stalpers
BACKGROUND AND PURPOSE: Regarding latest developments, the need of a radiotherapy 'Patterns of Care' survey was expressed by the Dutch National Platform Radiotherapy for Gynaecological Cancer (LPRGT). Therefore, this study investigated current practice for cervical cancer in all 16 radiation oncology centres in the Netherlands specialised in gynaecological oncology. MATERIAL AND METHODS: A structured 'patterns of care' questionnaire was completed and followed by an in-depth interview with radiation oncologists from all radiotherapy centres specialised in gynaecological oncology...
April 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28434272/wideband-acoustic-immittance-in-children-with-down-syndrome-prediction-of-middle-ear-dysfunction-conductive-hearing-loss-and-patent-pe-tubes
#20
Lisa L Hunter, Douglas H Keefe, M Patrick Feeney, David K Brown, Jareen Meinzen-Derr, Alaaeldin M Elsayed, Julia M Amann, Vairavan Manickam, Denis Fitzpatrick, Sally R Shott
OBJECTIVE: The purpose of this study was to evaluate pressurised wideband acoustic immittance (WAI) tests in children with Down syndrome (DS) and in typically developing children (TD) for prediction of conductive hearing loss (CHL) and patency of pressure equalising tubes (PETs). DESIGN: Audiologic diagnosis was determined by audiometry in combination with distortion-product otoacoustic emissions, 0.226 kHz tympanometry and otoscopy. WAI results were compared for ears within diagnostic categories (Normal, CHL and PET) and between groups (TD and DS)...
April 22, 2017: International Journal of Audiology
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