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https://www.readbyqxmd.com/read/28944773/the-effect-of-treatment-with-guanfacine-an-alpha2-adrenergic-agonist-on-dopaminergic-tone-in-tobacco-smokers-an-11-c-flb457-pet-study
#1
Christine M Sandiego, David Matuskey, Meaghan Lavery, Erin McGovern, Yiyun Huang, Nabeel Nabulsi, Jim Ropchan, Marina R Picciotto, Evan D Morris, Sherry A McKee, Kelly P Cosgrove
Guanfacine, a noradrenergic alpha2a agonist, reduced tobacco smoking in a 4-week trial and in animal models has been shown to reduce cortical dopamine release, which is critically involved in the reinforcing effect of tobacco smoking. We measured amphetamine-induced extrastriatal dopamine release before and after treatment with guanfacine with [(11)C]FLB457, a dopamine D2/D3 receptor radiotracer, and positron emission tomography (PET). Sixteen tobacco smokers had one set of [(11)C]FLB457 PET scans on the same day, one before and one at 2...
September 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28944759/optimization-of-an-ultralow-dose-high-resolution-pediatric-pet-scanner-design-based-on-monolithic-scintillators-with-dual-sided-digital-sipm-readout-a-simulation-study
#2
Ekaterina Mikhaylova, Valerio Tabacchini, Giacomo Borghi, Pieter Mollet, Ester D'Hoe, Dennis R Schaart, Stefaan Vandenberghe
The goal of this simulation study is the performance evaluation and comparison of six potential designs for a time-of-flight PET scanner for pediatric patients of up to about 12 years of age. It is designed to have a high sensitivity and provide high-contrast and high-resolution images. The simulated pediatric PET is a full ring scanner, consisting of 32 × 32 mm<sup>2</sup> monolithic LYSO:Ce crystals coupled to digital silicon photomultiplier (dSiPM) arrays. The six considered designs differ in axial lengths (27...
September 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28944558/imaging-the-neuroimmune-response-to-alcohol-exposure-in-adolescent-baboons-a-tspo-pet-study-using-18-f-dpa-714
#3
Wadad Saba, Sébastien Goutal, Sylvain Auvity, Bertrand Kuhnast, Christine Coulon, Virginie Kouyoumdjian, Irène Buvat, Claire Leroy, Nicolas Tournier
The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using translocator protein 18 kDa (TSPO) PET imaging, a non-invasive marker of glial activation, in adolescent baboons. Three different alcohol-naive adolescent baboons (3-4 years old, 9 to 14 kg) underwent (18) F-DPA-714 PET experiments before, during and 7-12 months after this initial alcohol exposure (0...
September 25, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28944403/prediction-of-disease-free-survival-by-the-pet-ct-radiomic-signature-in-non-small-cell-lung-cancer-patients-undergoing-surgery
#4
Margarita Kirienko, Luca Cozzi, Lidija Antunovic, Lisa Lozza, Antonella Fogliata, Emanuele Voulaz, Alexia Rossi, Arturo Chiti, Martina Sollini
PURPOSE: Radiomic features derived from the texture analysis of different imaging modalities e show promise in lesion characterisation, response prediction, and prognostication in lung cancer patients. The present study aimed to identify an images-based radiomic signature capable of predicting disease-free survival (DFS) in non-small cell lung cancer (NSCLC) patients undergoing surgery. METHODS: A cohort of 295 patients was selected. Clinical parameters (age, sex, histological type, tumour grade, and stage) were recorded for all patients...
September 24, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28944041/understanding-the-context-for-pet-cat-and-dog-feeding-and-exercising-behaviour-among-pet-owners-in-ireland-a-qualitative-study
#5
Martin J Downes, Catherine Devitt, Marie T Downes, Simon J More
BACKGROUND: Pet cat and dog obesity contributes to increased risk of several diseases, including cancer and diabetes mellitus as well as a worsening of orthopaedic problems, and a reduction in survival rate. This study aims to develop a better understanding of cat and dog owners' self-reported beliefs and factors that influence owner behaviour around feeding and exercising their pet cat or dog, as there is a lack of in-depth understanding in this area. Seven focus group discussions, with 43 pet owners in total, were conducted...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28943748/understanding-the-potential-of-paro-for-healthy-older-adults
#6
Sean A McGlynn, Shawn Kemple, Tracy L Mitzner, Chih-Hung Aaron King, Wendy A Rogers
As the population ages, there is an increasing need for socio-emotional support for older adults. A potential way to meet this need is through interacting with pet-type robots such as the seal robot, PARO. There was a need to extend research on PARO's potential benefits beyond cognitively impaired and dependently living older adults. Because independently living, cognitively intact older adults may also have socio-emotional needs, the primary goal of this study was to investigate their attitudes, emotions, and engagement with PARO to identify its potential applicability to this demographic...
April 2017: International Journal of Human-computer Studies
https://www.readbyqxmd.com/read/28943570/the-notable-appearance-of-pulmonary-artery-intimal-sarcoma-on-positron-emission-tomography-pet-ct
#7
Motoko Tachihara, Yugo Tanaka, Yoh Zen, Yoshihiro Nishimura
No abstract text is available yet for this article.
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943569/intrahepatic-cholangiolocellular-and-cholangiocellular-carcinoma-differences-in-the-18f-fdg-pet-ct-findings
#8
Yoshiko Takahashi, Shuichi Sato, Hitomi Ishitobi, Makoto Nagaoka, Yoshiya Kobayashi, Hiroyuki Fukuhara, Mika Yuki, Yoshinori Komazawa, Hiroyuki Kuroda, Toshihiro Shizuku
Cholangiolocellular carcinoma is a minor primary cancerous tumor of the liver and its coexistence with intrahepatic cholangiocarcinoma in the liver is rare. We herein report a case of concurrent cholangiolocellular carcinoma and intrahepatic cholangiocarcinoma in the liver, in addition to a rectal G1 neuroendocrine tumor, a so-called carcinoid. The intrahepatic tumors showed a different uptake in the 18-fluoro-2-deoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) findings. In addition to conventional dynamic contrast-enhanced CT, we concluded that FDG PET/CT could therefore be a helpful modality to identify the properties of both cholangiolocellular carcinoma and intrahepatic cholangiocarcinoma...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943046/radical-radiation-therapy-for-oligometastatic-breast-cancer-results-of-a-prospective-phase-ii-trial
#9
Marco Trovo, Carlo Furlan, Jerry Polesel, Francesco Fiorica, Stefano Arcangeli, Niccolò Giaj-Levra, Filippo Alongi, Alessandro Del Conte, Loredana Militello, Elena Muraro, Debora Martorelli, Simon Spazzapan, Massimiliano Berretta
BACKGROUND AND PURPOSE: We conducted a prospective phase II multicentric trial to determine if radical radiation therapy to all metastatic sites might improve the progression-free survival (PFS) in oligometastatic breast cancer patients. Secondary endpoints were local control (LC), overall survival (OS) and toxicity. METHODS AND MATERIALS: Inclusion criteria were the following: oligometastatic breast cancer with ≤5 metastatic sites, FDG-PET/CT staging, no brain metastases, primary tumor controlled...
September 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28942939/relation-of-coronary-flow-reserve-to-other-findings-on-positron-emission-tomography-myocardial-perfusion-imaging-and-left-heart-catheterization-in-patients-with-end-stage-renal-disease-being-evaluated-for-kidney-transplant
#10
Yehuda Paz, Rachelle Morgenstern, Richard Weinberg, Mariana Chiles, Navdeep Bhatti, Ziad Ali, Sumit Mohan, Sabahat Bokhari
Cardiovascular disease is the leading cause of death in patients with end-stage renal disease (ESRD) and often goes undetected. Abnormal coronary flow reserve (CFR), which predicts increased risk of cardiac death, may be present in patients with ESRD without other evidence of coronary artery disease (CAD). We prospectively studied 131 patients who had rest and dipyridamole pharmacologic stress N(13)-ammonia positron emission tomography myocardial perfusion imaging (PET MPI) for kidney transplant evaluation...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28942820/domestic-reptiles-as-source-of-zoonotic-bacteria-a-mini-review
#11
REVIEW
Valentina Virginia Ebani
Captive reptiles, always more often present in domestic environment as pets, may harbor and excrete a large variety of zoonotic pathogens. Among them, Salmonella is the most well-known agent, whereas there are very scant data about infections by mycobacteria, chlamydiae and leptospirae in cold-blooded animals. However, the investigations that found antibody reactions and/or the bacteria in samples collected from free-ranging and captive reptiles show that herpetofauna may be involved in the epidemiology of these infections...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28942411/dog-bites-and-diabetic-peripheral-neuropathy-a-dangerous-combination
#12
Mussa Mensa, Jonathan James Cubitt, Muhammad Javed, Thomas Bragg
All animal bites have the potential to cause significant infection. In the UK, dogs are the most common source of bites. Incidence of hospital attendances attributable to dog bites has risen over the last decade. Patient groups at particular risk of bites and/or complications of infection include those at extremes of age, immunosuppressed and patients with diabetes. We report the case of a patient with diabetic peripheral neuropathy, who was admitted on two separate occasions with unprovoked bites to his toes whilst asleep, by his pet dog...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28942164/controlling-the-melt-dripping-of-polyester-fabrics-by-tuning-the-ionic-strength-of-polyhedral-oligomeric-silsesquioxane-and-sodium-montmorillonite-coatings-assembled-through-layer-by-layer
#13
Federico Carosio, Alessandro Di Pierro, Jenny Alongi, Alberto Fina, Guido Saracco
This work deals with the Layer by Layer (LbL) assembly of hybrid organic/inorganic flame retardant coatings made of Octa-ammonium POSS (polyhedral oligomeric silsesquioxane) and sodium montmorillonite clay on polyester (PET) fabrics. The effects of ionic strength on the achieved flame retardancy properties were investigated. The coating growth asa function of different ionic strengths was evaluated by infrared spectroscopy. 0.10M NaCl was found able to promote the highest adsorption of each coating species at each deposition step strongly affecting clay stacking as evaluated by X-ray diffraction measurements...
September 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28942077/transcervical-extended-mediastinal-lymphadenectomy-experience-from-a-north-american-cancer-center
#14
Sai Yendamuri, Athar Battoo, Grace Dy, Hongbin Chen, Jorge Gomez, Anurag K Singh, Mark Hennon, Chukwumere E Nwogu, Elisabeth U Dexter, Miriam Huang, Anthony Picone, Todd L Demmy
BACKGROUND: Accurate staging of the mediastinum is a critical element of therapeutic decision making in non-small cell lung cancer. We sought to determine the utility of transcervical extended mediastinal lymphadenectomy (TEMLA) in staging non-small cell lung cancer for large central tumors and after induction therapy. METHODS: A retrospective record review was performed of all patients who underwent TEMLA at our institution from 2010 to 2015. Clinical stage as assessed by positron emission tomography integrated with computed tomography (PET-CT), stage as assessed by TEMLA, final pathologic stage, lymph node yield, and clinical characteristics of tumors were assessed along with TEMLA-related perioperative morbidity...
September 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28942016/positron-emission-tomography-based-assessment-of-metabolic-tumor-volume-predicts-survival-after-autologous-hematopoietic-cell-transplantation-for-hodgkin-lymphoma
#15
Vít Procházka, Rakhee S Gawande, Zuzan Cayci, Jerry W Froelich, Qing Cao, Chris Wilke, Kathryn Dusenbery, Daniel J Weisdorf, Veronika Bachanova
Autologous hematopoietic cell transplantation (AHCT) is curative for 60% of patients with relapsed or refractory Hodgkin lymphoma (R/R HL). A more precise assessment of the depth of remission prior to AHCT may help to identify patients likely to benefit from AHCT. We aimed to determine whether PET-based quantitative parameters of total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), and maximal standardized uptake volume (SUVmax) measured prior to AHCT predict progression-free survival (PFS) after transplant...
September 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28941866/-68-ga-psma-pet-ct-in-prostate-cancer
#16
J R García Garzón, M de Arcocha Torres, R Delgado-Bolton, F Ceci, S Alvarez Ruiz, J Orcajo Rincón, A P Caresia Aróztegui, M J García Velloso, A M García Vicente
Positron emission tomography/computed tomography (PET/CT) with (68)Ga-PSMA is a non-invasive diagnostic technique to image prostate cancer with increased prostate-specific membrane antigen (PSMA) expression. PSMA is a transmembrane protein present in all prostatic tissues. Increased PSMA expression is seen in several malignancies, although prostate cancer is the tumour where it presents higher concentrations. Almost all prostate adenocarcinomas show PSMA expression in most of lesions, primary and metastatic...
September 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28941773/exploring-the-associations-between-parent-reported-biological-indoor-environment-and-airway-related-symptoms-and-allergic-diseases-in-children
#17
Alisa Weber, Nina Fuchs, Susanne Kutzora, Lana Hendrowarsito, Uta Nennstiel-Ratzel, Erika von Mutius, Caroline Herr, Stefanie Heinze
OBJECTIVES: Asthma and allergic rhinitis are diseases which require special attention in childhood. Risk factors for these diseases are manifold and include environmental factors. Previous studies have shown associations between indoor mould and respiratory diseases in children. Besides indoor mould, organic waste storage, potted plants, pets and crowding could influence the microbial indoor environment at home and the respiratory health of children. Our aim was therefore to explore the associations of these factors with airway-related symptoms and respiratory diseases in preschoolers...
September 6, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28941755/the-diagnostic-value-of-fdg-and-amyloid-pet-in-alzheimer-s-disease-a-systematic-review
#18
REVIEW
Louise Rice, Sotirios Bisdas
PURPOSE: By 2050 it is projected that 115 million people worldwide will have Alzheimer's Disease (AD) [1]. Recent attempts have been made to redefine the diagnostic criteria of AD to include markers of neurodegeneration - measurable by FDG-PET - and markers of amyloid accumulation - measurable by amyloid-PET. MATERIALS AND METHODS: A systematic review of the literature was performed to examine the current diagnostic use of amyloid and FDG PET. MEDLINE and EMBASE databases and the Cochrane Database were searched for relevant papers RESULTS AND DISCUSSION: This search resulted in twenty-nine papers on amyloid imaging, twenty-three papers on FDG-PET and eight papers which utilized both techniques...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28941715/comparison-of-different-methods-for-mp-detection-what-can-we-learn-from-them-and-why-asking-the-right-question-before-measurements-matters
#19
Anna M Elert, Roland Becker, Erik Duemichen, Paul Eisentraut, Jana Falkenhagen, Heinz Sturm, Ulrike Braun
In recent years, an increasing trend towards investigating and monitoring the contamination of the environment by microplastics (MP) (plastic pieces < 5 mm) has been observed worldwide. Nonetheless, a reliable methodology that would facilitate and automate the monitoring of MP is still lacking. With the goal of selecting practical and standardized methods, and considering the challenges in microplastics detection, we present here a critical evaluation of two vibrational spectroscopies, Raman and Fourier transform infrared (FTIR) spectroscopy, and two extraction methods: thermal extraction desorption gas chromatography mass spectrometry (TED-GC-MS) and liquid extraction with subsequent size exclusion chromatography (SEC) using a soil with known contents of PE, PP, PS and PET as reference material...
September 20, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28941158/prognostic-and-predictive-role-of-18-f-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-in-patients-with-unresectable-malignant-pleural-mesothelioma-mpm-treated-with-up-front-pemetrexed-based-chemotherapy
#20
Paolo Andrea Zucali, Egesta Lopci, Giovanni Luca Ceresoli, Laura Giordano, Matteo Perrino, Gianluigi Ciocia, Letizia Gianoncelli, Elena Lorenzi, Matteo Simonelli, Fabio De Vincenzo, Lucia Rebecca Setti, Cristiana Bonifacio, Maria Bonomi, Emilio Bombardieri, Arturo Chiti, Armando Santoro
The aim of this study was to evaluate the role of metabolic parameters analyzed at baseline and at interim FDG-PET in predicting disease outcome in unresectable MPM patients receiving pemetrexed-based chemotherapy. A consecutive series of MPM patients treated between February 2004 and July 2013 with first-line pemetrexed-based chemotherapy, and evaluated by FDG-PET and CT scan at baseline and after two cycles of chemotherapy, was reviewed. Best CT scan response was assessed according to modified RECIST criteria...
September 21, 2017: Cancer Medicine
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