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https://www.readbyqxmd.com/read/29666252/mechanisms-of-sampling-interstitial-fluid-from-skin-using-a-microneedle-patch
#1
Pradnya P Samant, Mark R Prausnitz
Although interstitial fluid (ISF) contains biomarkers of physiological significance and medical interest, sampling of ISF for clinical applications has made limited impact due to a lack of simple, clinically useful techniques that collect more than nanoliter volumes of ISF. This study describes experimental and theoretical analysis of ISF transport from skin using microneedle (MN) patches and demonstrates collection of >1 µL of ISF within 20 min in pig cadaver skin and living human subjects using an optimized system...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665109/improving-the-performance-time-and-accuracy-of-ultrasound-guided-interventions-a-randomized-controlled-double-blind-trial-of-the-line-of-sight-approach-and-the-apples-mnemonic
#2
John W Norbury, Natalie C Karr, Vivek Sindhi, Kimberly M Rathbun, Stephen C Charles, Michael B McIver, Eric J Morrison
OBJECTIVES: To determine whether the line-of-sight approach improved the performance time and accuracy of ultrasound (US)-guided needle placement targeting the subdeltoid bursa in a cadaver among novice operators compared to the side approach. A secondary objective was to determine whether participants thought the APPLES (angle, position, perpendicular, line up, entry, sweep) mnemonic was a helpful guide for performing the procedure. METHODS: Medical students and residents were randomized into either a line-of-sight or side approach group and then crossed over to the other group...
April 17, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29664880/split-depressed-lateral-tibial-plateau-fractures-a-comparision-of-augmented-percutaneous-screws-versus-augmented-plate-and-screw-construct-in-a-cadaveric-model
#3
Richard J Bowles, Vivek Chadayammuri, Antonio Brecevich, Todd Baldini, Cyril Mauffrey
OBJECTIVES: To compare the strength of fixation of percutaneous screw versus plate/screw fixation in a paired cadaver model of OTA 41-B3 (1) (Schatzker type II) split depression fractures of the lateral tibial plateau. METHODS: Six matched pairs of cadaveric knees were acquired. A OTA 41-B3 (Schatzker type II) split depression fracture was created in all specimens using a standardized method. One specimen from each matched pair of knees was fixed with percutaneous screws, and the other was fixed with a plate/screw construct...
April 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29664831/design-of-mini-latissimus-dorsi-flap-based-on-thoracodorsal-vascular-patterns
#4
Ehab Mostafa Elzawawy, Melad Naim Kelada, Ahmed Farouk Al Karmouty
INTRODUCTION: Latissimus dorsi (LD) flap has been used for reconstructive purposes in oncoplastic breast surgery. Using large part of the muscle as a flap leads to a residual functional loss. Muscle sparing and mini LD flaps can be used with no functional sequelae. However, the design of such flap presents a challenge. METHODS: Twenty cadavers were dissected on both sides to identify the different vascular patterns of the thoracodorsal (TD) pedicle. The vessels were counted, and the following measurements were taken: diameter, length, distance from inferior angel of scapula, and vertebral level...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29664183/posterior-tibial-perforators-relationship-with-superficial-nerves-and-veins-a-cadaver-study
#5
Antonio Bulla, Alberto Bolletta, Luca Fiorot, Matteo Maffei, Pasquale Bandiera, Vincent Casoli, Andrea Montella, Gian Vittorio Campus
BACKGROUND: Most authors have evaluated the location of lower leg arterial perforators, but little is still known about the relationship between the arterial network and great saphenous vein (GSV) and saphenous nerve (SN). The aim of this study is to evaluate the relationship between the arterial network of the posterior tibial artery perforators, the cutaneous nerves, and the superficial venous system in the lower one third of the leg. METHODS: Eighteen lower limbs from cadavers were used for this study...
April 17, 2018: Microsurgery
https://www.readbyqxmd.com/read/29664177/-osler-warned-was-william-osler-a-grave-robber-while-at-mcgill-or-was-he-a-victim-or-perpetrator-of-one-final-practical-joke
#6
James R Wright
Bodysnatching was an illegal way to procure cadavers for anatomical dissection before the existence of effective anatomy legislation. As knowledge of anatomy was fundamental to medical practice, many famous 19th century physicians turned a blind eye to this activity or even participated. Sir William Osler, perhaps the most revered physician of all time, received his medical degree from McGill University in 1872 and then served as pathologist at Montreal General Hospital from 1874 to 1884, where he began a career which culminated in him becoming both the first Professor of Medicine at Johns Hopkins and then Regius Professor at Oxford...
April 17, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29664158/spread-of-injectate-around-hip-articular-sensory-branches-of-the-femoral-nerve-in-cadavers
#7
N D Nielsen, M Greher, B Moriggl, R Hoermann, T D Nielsen, J Børglum, T F Bendtsen
BACKGROUND: Anatomical knowledge dictates that regional anaesthesia after total hip arthroplasty requires blockade of the hip articular branches of the femoral and obturator nerves. A direct femoral nerve block increases the risk of fall and impedes mobilisation. We propose a selective nerve block of the hip articular branches of the femoral nerve by an ultrasound-guided injection in the plane between the iliopsoas muscle and the iliofemoral ligament (the iliopsoas plane). The aim of this study was to assess whether dye injected in the iliopsoas plane spreads to all hip articular branches of the femoral nerve...
April 17, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29663091/anatomical-feasibility-study-of-flexor-hallucis-longus-transfer-in-treatment-of-achilles-tendon-and-posteromedial-portal-of-ankle-arthroscopy
#8
Haijiao Mao, Linger Wang, Wenwei Dong, Zhenxin Liu, Weigang Yin, Dachuan Xu, Keith L Wapner
PURPOSE: The aim of this study was to evaluate the occurrence of anatomical variations of the musculotendinous junction of the flexor hallucis longus (FHL) muscle, the relationship between FHL tendon or muscle and the tibial neurovascular bundle at the level of the posterior ankle joint in human cadavers. METHODS: Seventy embalmed feet from 20 male and 15 female cadavers, the cadavers' mean age was 65.4 (range from 14 to 82) years, were dissected and anatomically classified to observe FHL muscle morphology define the relationship between FHL tendon or muscle and the tibial neurovascular bundle...
April 16, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29662779/finite-element-analysis-of-biomechanical-effects-of-total-ankle-arthroplasty-on-the-foot
#9
Yan Wang, Zengyong Li, Duo Wai-Chi Wong, Cheng-Kung Cheng, Ming Zhang
Background: Total ankle arthroplasty is gaining popularity as an alternation to ankle arthrodesis for end-stage ankle arthritis. Owing to the complex anatomical characteristics of the ankle joint, total ankle arthroplasty has higher failure rates. Biomechanical exploration of the effects of total ankle arthroplasty on the foot and ankle is imperative for the precaution of postoperative complications. The objectives of this study are (1) to investigate the biomechanical differences of the foot and ankle between the foot with total ankle arthroplasty and the intact foot and (2) to investigate the performance of the three-component ankle prosthesis...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662769/human-and-bovine-spinal-disc-mechanics-subsequent-to-trypsin-injection
#10
Jeremy Alsup, Timothy Bishop, Dennis Eggett, Anton E Bowden
Objective: To investigate the biomechanical effects of injections of a protease on the characteristics of bovine coccygeal and human lumbar disc motion segments. Methods: Mechanics of treated tissues were measured immediately after injection and 3 h after injection. Motion segments underwent axial rotation and flexion-extension loading. Results: Stiffness and neutral zone parameters experienced significant changes over time, with bovine tissues more strongly affected than human cadaver tissues...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661686/utilization-of-bia-derived-bone-mineral-estimates-exerts-minimal-impact-on-body-fat-estimates-via-multicompartment-models-in-physically-active-adults
#11
Brett S Nickerson, Grant M Tinsley
The purpose of this study was to compare body fat estimates and fat-free mass (FFM) characteristics produced by multicompartment models when utilizing either dual energy X-ray absorptiometry (DXA) or single-frequency bioelectrical impedance analysis (SF-BIA) for bone mineral content (BMC) in a sample of physically active adults. Body fat percentage (BF%) was estimated with 5-compartment (5C), 4-compartment (4C), 3-compartment (3C), and 2-compartment (2C) models, and DXA. The 5C-Wang with DXA for BMC (i.e., 5C-WangDXA ) was the criterion...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29661210/use-of-a-life-size-three-dimensional-printed-spine-model-for-pedicle-screw-instrumentation-training
#12
Hyun Jin Park, Chenyu Wang, Kyung Ho Choi, Hyong Nyun Kim
BACKGROUND: Training beginners of the pedicle screw instrumentation technique in the operating room is limited because of issues related to patient safety and surgical efficiency. Three-dimensional (3D) printing enables training or simulation surgery on a real-size replica of deformed spine, which is difficult to perform in the usual cadaver or surrogate plastic models. The purpose of this study was to evaluate the educational effect of using a real-size 3D-printed spine model for training beginners of the free-hand pedicle screw instrumentation technique...
April 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29660990/novel-radiographic-assessment-of-the-cribriform-plate
#13
Kimia G Ganjaei, Zachary M Soler, Elliott D Mappus, Robert J Taylor, Mitchell L Worley, Jennifer K Mulligan, Jose L Mattos, Nicholas R Rowan, Guilherme J M Garcia, Judy R Dubno, Mark A Eckert, Lois J Matthews, Rodney J Schlosser
Background The cribriform plate (CP) is a common site of spontaneous cerebrospinal fluid (SCSF) leaks. Radiographic assessment of the anterior and lateral skull base has shown thinner bone in patients with SCSFs; however, prior assessment of the CP has required postmortem cadaver dissection. Objective To develop novel radiographic techniques to assess the anatomy of the CP. Methods Computed tomography (CT) scans were performed on cadaveric specimens. Bone density and anatomy of a predefined volume of interest of the posterior CP were assessed by two independent reviewers...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29660055/accuracy-assessment-of-pedicle-and-lateral-mass-screw-insertion-assisted-by-customized-3d-printed-drill-guides-a-human-cadaver-study
#14
Peter A J Pijpker, Joep Kraeima, Max J H Witjes, D L Marinus Oterdoom, Maarten H Coppes, Rob J M Groen, Jos M A Kuijlen
BACKGROUND: Accurate cervical screw insertion is of paramount importance considering the risk of damage to adjacent vital structures. Recent research in 3-dimensional (3D) technology describes the advantage of patient-specific drill guides for accurate screw positioning, but consensus about the optimal guide design and the accuracy is lacking. OBJECTIVE: To find the optimal design and to evaluate the accuracy of individualized 3D-printed drill guides for lateral mass and pedicle screw placement in the cervical and upper thoracic spine...
April 5, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29659448/sural-nerve-splitting-in-reverse-sural-artery-perforator-flap-anatomical-study-in-40-cadaver-legs
#15
Hyeonwoo Kim, Julong Hu, Hak Chang, Byung Jun Kim
No abstract text is available yet for this article.
January 20, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29659436/a-novel-technique-of-ultrasound-guided-selective-mandibular-nerve-block-with-a-lateral-pterygoid-plate-approach-a-cadaveric-study
#16
Wirinaree Kampitak, Tanvaa Tansatit, Yasuyuki Shibata
BACKGROUND AND OBJECTIVES: We aimed to describe a novel technique of ultrasound-guided selective mandibular nerve block with a lateral pterygoid plate (LPP) approach and to assess its feasibility and accuracy in a soft cadaver model. METHODS: Ten soft cadavers were studied. A curved array ultrasound transducer was applied over 1 side of the face of the cadaver, in an open-mouth position. The transducer was placed transversely below the zygomatic arch and tilted in the caudal-to-cranial direction to identify the boundary of the LPP...
April 14, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29659197/morphological-features-of-the-branching-pattern-of-the-hypoglossal-nerve
#17
Yujiro Sakamoto
The hypoglossal or twelfth cranial nerve is the motor nerve to the extrinsic and intrinsic muscles of the tongue, and the superior root of the ansa cervicalis and the thyrohyoid and geniohyoid branches are delivered through the nerve. This study investigated the muscular branches of the hypoglossal nerve to clarify their spatial relationships with the muscles of the tongue and the neighboring structures. The muscles and the nerve were gross anatomically examined in 42 cadavers. The superior root and the thyrohyoid branch left the nerve near the occipital and lingual arteries, respectively...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29659175/extracranial-course-of-the-facial-nerve-revisited
#18
P Martínez-Pascual, E Maranillo, T Vázquez, C Simón, J M Lasso, J R Sanudo
INTRODUCTION: The extrapetrous course of the facial nerve has been a matter of study and debate since XIX century. Two different classifications have been classically proposed and widely accepted by most of the authors. Nevertheless, there are reported cases which do not fit in any of those. The aim of this study is to propose a new and useful classification. MATERIAL AND METHODS: We have used 23 embalmed Caucasian adult cadavers (11male and 12 female) belonging to the Bodies Donation and Dissecting Rooms Centre of the University Complutense of Madrid...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29658405/real-time-intracochlear-imaging-of-automated-cochlear-implant-insertions-in-whole-decalcified-cadaver-cochleas-using-ultrasound
#19
Thomas G Landry, Guy Earle, Jeremy A Brown, Manohar L Bance
OBJECTIVES: This study aimed to determine the feasibility of combining high-frequency ultrasound imaging, automated insertion, and force sensing to yield more information about cochlear implant insertion dynamics. METHODS: An apparatus was developed combining these aspects along with software to control implant and imaging probe positions. Decalcified unfixed human cochleas were implanted at various speeds, insertion sites, and implant models while imaging near the implant tip throughout insertion and recording force data from the cochlea mounting stage...
April 16, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29658301/avoiding-pitfalls-of-tibiotalocalcaneal-nail-malposition-with-internal-rotation-axial-heel-view
#20
Ryan Callahan, Paul Juliano, Umur Aydogan, Justin Clayton
BACKGROUND: Tibiotalocalcaneal (TTC) nails are often used for complex hind foot arthrodesis and deformity correction. The natural valgus alignment of the hindfoot creates a challenge to optimum placement of the guidewire and eventual nail with a straight or valgus-curved nail. METHODS: Five fresh frozen cadavers were used for placement of a TTC guidewire with standard anterior-posterior (AP), lateral, and Harris axial heel views as a reference for proper placement...
April 1, 2018: Foot & Ankle Specialist
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