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https://www.readbyqxmd.com/read/28448622/goniodysgenesis-variability-and-activity-of-cyp1b1-genotypes-in-primary-congenital-glaucoma
#1
María T García-Antón, Juan J Salazar, Rosa de Hoz, Blanca Rojas, Ana I Ramírez, Alberto Triviño, José-Daniel Aroca-Aguilar, Julián García-Feijoo, Julio Escribano, José M Ramírez
Mutations in the CYP1B1 gene are currently the main known genetic cause of primary congenital glaucoma (PCG), a leading cause of blindness in children. Here, we analyze for the first time the CYP1B1 genotype activity and the microscopic and clinical phenotypes in human PCG. Surgical pieces from trabeculectomy from patients with PCG (n = 5) and sclerocorneal rims (n = 3) from cadaver donors were processed for transmission electron microscopy. Patients were classified into three groups depending on goniodysgenesis severity, which was influenced by CYP1B1 enzymatic activity...
2017: PloS One
https://www.readbyqxmd.com/read/28447928/evaluation-of-three-dimensional-versus-conventional-laparoscopy-for-kidney-transplant-procedures-in-a-human-cadaveric-model
#2
Bulang He, Lingjun Mou, Ronald De Roo, Gabrielle C Musk, Jeffrey M Hamdorf
OBJECTIVES: There are increased reports that kidney transplant can be performed by laparoscopic surgery. The further development of this technique could revolutionize human kidney transplant surgery. However, laparoscopic kidney transplant demands a high level of skill for vascular anastomoses. The emerging technology of the three-dimensional, high-definition laparoscopic system may facilitate the application of this technique. Therefore, in this study, we evaluated this system in performing kidney transplant surgery versus the two-dimensional laparoscopic system...
April 27, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28447150/anatomical-status-of-the-human-palatopharyngeal-sphincter-and-its-functional-implications
#3
Kaori Sumida, Yoshinori Ando, Shinichiro Seki, Kikuji Yamashita, Akira Fujimura, Otto Baba, Seiichiro Kitamura
PURPOSE: The transition muscle between the palatopharyngeus (PP) and the superior constrictor of the pharynx (SCP) encircles the pharyngeal isthmus from behind and is designated as the palatopharyngeal sphincter (PPS). The PPS is inferred to play important roles for velopharyngeal closure, but its existence remains controversial and its roles have been regarded as being played by the SCP. The present study aimed to clarify the anatomical status and functional implications of the PPS. MATERIALS AND METHODS: Macroscopic and microscopic examinations were performed on 39 and 4 cadavers, respectively...
April 26, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28446072/the-influence-of-force-direction-on-the-fracture-pattern-and-fracture-resistance-of-canine-teeth-in-dogs
#4
Stephanie Goldschmidt, Catherine Zimmerman, Caitlyn Collins, Scott Hetzel, Heidi-Lynn Ploeg, Jason W Soukup
Biomechanical studies of the elongated canine tooth of animals are few, and thus our understanding of mechanical and physical properties of animal teeth is limited. The objective of the present study was to evaluate the influence of force direction on fracture resistance and fracture pattern of canine teeth in an ex vivo dog cadaver model. Forty-five extracted canine teeth from laboratory beagle dogs were standardized by hard tissue volume and randomly distributed among 3 force direction groups. The teeth were secured within a universal testing machine and a load was applied at different directions based on testing group...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28445196/the-use-of-a-fresh-tissue-cadaver-model-for-the-instruction-of-dermatological-procedures-a-laboratory-study-for-training-medical-students
#5
Jose A Cervantes, Collin M Costello, Melody Maarouf, Hilary C McCrary, Nathalie C Zeitouni
BACKGROUND: A realistic model for the instruction of basic dermatologic procedural skills was developed, while simultaneously increasing medical student exposure to the field of dermatology. OBJECTIVE: The primary purpose of the authors' study was to evaluate the utilization of a fresh-tissue cadaver model (FTCM) as a method for the instruction of common dermatologic procedures. The authors' secondary aim was to assess students' perceived clinical skills and overall perception of the field of dermatology after the lab...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28444825/3-tesla-magnetic-resonance-imaging-study-of-the-normal-canine-femoral-and-sciatic-nerves
#6
Christine Sievert, Henning Richter, Dominic Gascho, Patrick R Kircher, Inés Carrera
Understanding the normal course and optimizing visualization of the canine peripheral nerves of the lumbar plexus, in particular the sciatic and the femoral nerves, is essential when interpreting images of patients with suspected peripheral neuropathies such as inflammatory or neoplastic conditions. The purpose of this prospective, anatomic study was to describe the magnetic resonance imaging (MRI) anatomy of the normal canine femoral and sciatic nerves and to define the sequences in which the nerves are best depicted...
April 25, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28444241/cervical-spine-muscle-tendon-unit-length-differences-between-neutral-and-forward-head-postures-biomechanical-study-using-human-cadaveric-specimens
#7
Saeed Khayatzadeh, Olivia A Kalmanson, Dale Schuit, Robert M Havey, Leonard I Voronov, Alexander J Ghanayem, Avinash G Patwardhan
Background: Forward Head Posture (FHP) may be associated with neck pain and poor health-related quality of life. Literature describes only qualitative muscle length changes associated with FHP. Objective: To quantify how muscle-tendon unit lengths are altered when human cadaveric specimens are placed in alignments representing different severities of FHP. Design: Biomechanical study using 13 fresh-frozen cadaveric cervical spine specimens (Occiput-T1, 54±15yrs)...
April 21, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28442968/sonographic-detection-of-tracheal-or-esophageal-intubation-a-cadaver-study
#8
Ayse B Ozer, Mustafa Ozdemir, Sibel Ozcan
No abstract text is available yet for this article.
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28441055/ex-vivo-biomechanical-evaluation-of-pigeon-columba-livia-cadaver-intact-humeri-and-ostectomized-humeri-stabilized-with-caudally-applied-titanium-locking-plate-or-stainless-steel-nonlocking-plate-constructs
#9
Brett G Darrow, Jeffrey J Biskup, Joseph P Weigel, Michael P Jones, Xie Xie, Peter K Liaw, Josh L Tharpe, Aashish Sharma, Dayakar Penumadu
OBJECTIVE To evaluate mechanical properties of pigeon (Columba livia) cadaver intact humeri versus ostectomized humeri stabilized with a locking or nonlocking plate. SAMPLE 30 humeri from pigeon cadavers. PROCEDURES Specimens were allocated into 3 groups and tested in bending and torsion. Results for intact pigeon humeri were compared with results for ostectomized humeri repaired with a titanium 1.6-mm screw locking plate or a stainless steel 1.5-mm dynamic compression plate; the ostectomized humeri mimicked a fracture in a thin cortical bone...
May 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28440591/imaging-collector-channel-entrance-with-a-new-intraocular-micro-probe-swept-source-optical-coherence-tomography
#10
Chen Xin, Xiaoya Chen, Meng Li, Yan Shi, Huaizhou Wang, Ruikang Wang, Ningli Wang
PURPOSE: To describe the use of a newly developed side-viewing catheter probe to provide the cross-sectional images of collector channel entrance (CCE), achieved by swept-source optical coherence tomography (SS-OCT). METHODS: A side-viewing SS-OCT catheter probe was developed that has a core probe diameter of 0.15 mm and an outer diameter of 0.25 mm, for the purpose of imaging CCEs within eye globe. Cadaver eyes harvested from swine and human were used to demonstrate its feasibility...
April 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28439940/impact-of-operator-experience-and-training-strategy-on-procedural-outcomes-with-leadless-pacing-insights-from-the-micra-transcatheter-pacing-study
#11
Mikhael El Chami, Robert C Kowal, Kyoko Soejima, Philippe Ritter, Gabor Z Duray, Petr Neuzil, Lluis Mont, Alexander Kypta, Venkata Sagi, J Harrison Hudnall, Kurt Stromberg, Dwight Reynolds
BACKGROUND: Leadless pacemaker systems have been designed to avoid the need for a pocket and transvenous lead. However, delivery of this therapy requires a new catheter-based procedure. This study evaluates the role of operator experience and different training strategies on procedural outcomes. METHODS: A total of 726 patients underwent implant attempt with the Micra transcatheter pacing system (TPS) by 94 operators trained in a teaching laboratory using a simulator, cadaver, and large animal models (lab training) or locally at the hospital with simulator/demo model and proctorship (hospital training)...
April 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28439694/modifications-to-a-3d-printed-temporal-bone-model-for-augmented-stapes-fixation-surgery-teaching
#12
Yann Nguyen, Elisabeth Mamelle, Daniele De Seta, Olivier Sterkers, Daniele Bernardeschi, Renato Torres
Functional outcomes and complications in otosclerosis surgery are governed by the surgeon's experience. Thus, teaching the procedure to residents to guide them through the learning process as quickly as possible is challenging. Artificial 3D-printed temporal bones are replacing cadaver specimens in many institutions to learn mastoidectomy, but these are not suitable for middle ear surgery training. The goal of this work was to adapt such an artificial temporal bone to aid the teaching of otosclerosis surgery and to evaluate this tool...
April 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28439406/angiographic-anatomy-of-the-extracranial-and-intracranial-portions-of-the-internal-carotid-arteries-in-donkeys
#13
Nurul Hayah Khairuddin, Martin Sullivan, Patrick J Pollock
BACKGROUND: In horses, the extracranial and intracranial pathway of the internal carotid artery has been described. The extracranial pathway of the internal carotid artery begins at the carotid termination and runs on the dorsal surface of the medial compartment of the guttural pouch. Thereafter the internal carotid artery passes through the foramen lacerum to continue intracranially, forming part of the rostrolateral quadrants of the cerebral arterial circle (Circle of Willis). The objectives of this study were to define and record the anatomy of the carotid arterial tree and the internal carotid artery in donkeys using angiographic techniques...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28438070/creation-of-a-novel-simulator-for-minimally-invasive-neurosurgery-fusion-of-3d-printing-and-special-effects
#14
Peter Weinstock, Roberta Rehder, Sanjay P Prabhu, Peter W Forbes, Christopher J Roussin, Alan R Cohen
OBJECTIVE Recent advances in optics and miniaturization have enabled the development of a growing number of minimally invasive procedures, yet innovative training methods for the use of these techniques remain lacking. Conventional teaching models, including cadavers and physical trainers as well as virtual reality platforms, are often expensive and ineffective. Newly developed 3D printing technologies can recreate patient-specific anatomy, but the stiffness of the materials limits fidelity to real-life surgical situations...
April 25, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28435114/the-decussating-fibers-of-the-lumbar-thoracolumbar-fascia-a-landmark-for-identifying-the-l5-spinous-process
#15
Fernando Alonso, Tarush Rustagi, Christian Fisahn, Doniel Drazin, Brady Gardner, Joe Iwanaga, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: The thoracolumbar fascia has been well studied and is known to have crisscrossing fibers. Based on surgical experience, we have hypothesized that the decussating fibers of this fascia may indicate a specific vertebral level. Therefore, the following anatomical study was performed. METHODS: Twenty adult fresh frozen cadavers aged 72-84 years old at death were placed in the prone position and the skin of the lumbar and upper sacrum was removed. Careful attention was given to the thoracolumbar fascia and any fibers of it that grossly crossed the midline to inderdigitate with its contralateral counterpart...
April 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28434835/use-of-a-bicortical-button-to-safely-repair-the-distal-biceps-in-a-two-incision-approach-a-cadaveric-analysis
#16
Jonathan D Barlow, Ryan J McNeilan, Amy Speeckaert, Corey T Beals, Hisham M Awan
PURPOSE: No consensus has been reached on the most effective anatomic approach or fixation method for distal biceps repair. It is our hypothesis that, using a cortical biceps button through a 2-incision technique, the distal biceps can be safely and anatomically repaired. METHODS: A 2-incision biceps button distal biceps repair was completed on 10 fresh-frozen cadavers. The proximity of the guide pin to the critical structures of the forearm, including the posterior interosseous nerve and recurrent radial artery, was measured...
April 20, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28433348/the-influence-of-polyethylene-bearing-thickness-on-the-tibiofemoral-kinematics-of-a-bicruciate-retaining-total-knee-arthroplasty
#17
Geert Peersman, Josh Slane, Margo Dirckx, Arne Vandevyver, Philipp Dworschak, Thomas J Heyse, Lennart Scheys
BACKGROUND: The recently reintroduced bicruciate retaining Total Knee Arthroplasty (BCR TKA) is an effort to reproduce kinematics closer to the native knee. However, there is no data on appropriate balancing with this implant. Balancing is crucial and challenging as medial and lateral polyethylene (PE) inlays are modular, which allows for placement of different thicknesses in the medial and lateral compartments. This study aimed at providing a detailed kinematic view on balancing BCR TKA...
April 19, 2017: Knee
https://www.readbyqxmd.com/read/28432417/exploring-the-possibility-of-a-retrograde-embolism-pathway-from-the-facial-artery-to-the-ophthalmic-artery-system-in-vivo
#18
Hui Zheng, Lihong Qiu, Zonghui Liu, Yingjun Su, Xinyuan Pan, Sha Liu, Chenggang Yi
BACKGROUND: Blindness caused by soft tissue fillers is an extremely low-probability event, but it results in great concern because of its devastating consequences. Currently, the mechanism of an embolism is usually considered to be an accidental injection of fillers into the blood vessels of the face, such as a facial artery, and then retrograding into the ophthalmic artery system, which causes retinal ischemic necrosis. In addition, previous studies have shown that there are anastomoses between facial arteries and branches of the ophthalmic artery in cadavers...
April 21, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28430904/catheter-based-tricuspid-valve-replacement-first-experimental-data-of-a-newly-designed-bileaflet-stent-graft-prosthesis%C3%A2
#19
Henning F Lausberg, Rafal Gryszkiewicz, Maximilian Kuetting, Moritz Baumgaertner, Marcos Centola, Hans-Peter Wendel, Martina Nowak-Machen, David Schibilsky, Tobias Kruger, Christian Schlensak
OBJECTIVES: Moderate or severe degree tricuspid valve regurgitation (TVR) is associated with high rates of morbidity and mortality. Surgical correction as the only therapeutic option offers unsatisfactory results. Recently, several interventional procedures have been introduced clinically in a limited cohort. We present our initial experiments with an innovative interventional valved stent graft for treatment of TVR. METHODS: A newly designed porcine pericardium-covered nitinol stent graft with a lateral bicuspid valve was adapted to size in a cadaver study...
April 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28430102/variable-virulence-phenotype-of-xenorhabdus-bovienii-%C3%AE-proteobacteria-enterobacteriaceae-in-the-absence-of-their-vector-hosts
#20
John G McMullen, Rebecca McQuade, Jean-Claude Ogier, Sylvie Pagès, Sophie Gaudriault, S Patricia Stock
Xenorhabdus bovienii bacteria have a dual lifestyle: they are mutualistic symbionts to many species of Steinernema nematodes and are pathogens to a wide array of insects. Previous studies have shown that virulence of X.bovienii-Steinernema spp. pairs decreases when the nematodes associate with non-cognate bacterial strains. However, the virulence of the X. bovienii strains alone has not been fully investigated. In this study, we characterized the virulence of nine X. bovienii strains in Galleria mellonella and Spodoptera littoralis and performed a comparative genomic analysis to correlate observed phenotypes with strain genotypes...
April 22, 2017: Microbiology
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