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weight loss surgery, bariatric, roux-en-y, sleeve

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https://www.readbyqxmd.com/read/27912678/the-physiology-and-molecular-underpinnings-of-the-effects-of-bariatric-surgery-on-obesity-and-diabetes
#1
Simon S Evers, Darleen A Sandoval, Randy J Seeley
Bariatric surgeries, such as Roux-en-Y gastric bypass and vertical sleeve gastrectomy, produce significant and durable weight loss in both humans and rodents. Recently, these surgical interventions have also been termed metabolic surgery because they result in profound metabolic improvements that often surpass the expected improvement due to body weight loss alone. In this review we focus on the weight-loss independent effects of bariatric surgery, which encompass energy expenditure and macronutrient preference, the luminal composition of the gut (i...
November 28, 2016: Annual Review of Physiology
https://www.readbyqxmd.com/read/27903153/management-of-obesity
#2
Naji Alamuddin, Zayna Bakizada, Thomas A Wadden
This review examines weight loss and accompanying improvements in obesity-related comorbidities produced by intensive lifestyle intervention, pharmacotherapy, and bariatric surgery. Obese individuals lose approximately 6 to 8 kg (approximately 6% to 8% of initial weight) with 6 months of participation in a high-intensity lifestyle intervention (≥ 14 treatment visits) consisting of diet, physical activity, and behavior therapy. Such losses reduce progression to type 2 diabetes in at-risk people and decrease blood pressure and triglyceride levels...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27901287/randomized-trial-of-roux-en-y-gastric-bypass-versus-sleeve-gastrectomy-in-achieving-excess-weight-loss
#3
M Ignat, M Vix, I Imad, A D'Urso, S Perretta, J Marescaux, D Mutter
BACKGROUND: Robust data on quality of life (QoL) after different techniques of bariatric surgery are sparse. This RCT compared excess weight loss (EWL) and QoL after sleeve gastrectomy versus Roux-en-Y gastric bypass (RYGB). METHODS: Obese patients were assigned randomly to RYGB or sleeve gastrectomy. The primary outcome measure was EWL. Secondary outcomes included QoL, co-morbidity, adverse events, vitamin and glycolipid status. QoL was assessed before and annually after surgery, using the Moorehead-Ardelt Quality of Life Questionnaire II (M-A-QoLQII) and Gastrointestinal Quality of Life Index (GIQLI)...
November 30, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27899816/bariatric-surgery-for-obesity-and-metabolic-disorders-state-of-the-art
#4
REVIEW
Ninh T Nguyen, J Esteban Varela
Obesity is one of the most important public health conditions worldwide. Bariatric surgery for severe obesity is an effective treatment that results in the improvement and remission of many obesity-related comorbidities, as well as providing sustained weight loss and improvement in quality of life. Contemporary bariatric operations include Roux-en-Y gastric bypass, sleeve gastrectomy, adjustable gastric band and the duodenal switch. The vast majority of these procedures are now performed using laparoscopic technique, the main advantages of which include rapid recovery, the reduction of postoperative pain and the reduction of wound-related complications, compared with open surgery...
November 30, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27871812/effects-of-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-on-bone-mineral-density-and-marrow-adipose-tissue
#5
Miriam A Bredella, Logan B Greenblatt, Alireza Eajazi, Martin Torriani, Elaine W Yu
Bariatric surgery is associated with bone loss but skeletal consequences may differ between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the two most commonly performed bariatric procedures. Furthermore, severe weight loss is associated with high marrow adipose tissue (MAT); however, MAT is also increased in visceral adiposity. The purpose of our study was to determine the effects of RYGB and SG on BMD and MAT. We hypothesized that both bariatric procedures would lead to a decrease in BMD and MAT...
November 15, 2016: Bone
https://www.readbyqxmd.com/read/27818311/changes-in-bone-metabolism-after-bariatric-surgery-by-gastric-bypass-or-sleeve-gastrectomy
#6
Kaisa K Ivaska, Ville Huovinen, Minna Soinio, Jarna C Hannukainen, Virva Saunavaara, Paulina Salminen, Mika Helmiö, Riitta Parkkola, Pirjo Nuutila, Riku Kiviranta
Bariatric surgery results in rapid weight loss and beneficial metabolic effects, but may have negative effects on the skeleton. The objective of this prospective study was to evaluate changes in bone metabolism in response to bariatric surgery with two surgical techniques. 46 morbidly obese subjects (mean 44.9years, BMI 42.1) with (n=19) or without (n=27) type 2 diabetes (T2DM) at baseline underwent either Roux-en-Y gastric bypass (RYGB, n=21) or sleeve gastrectomy (SG, n=25). Bone turnover markers (CTX, PINP, TRAcP5b, TotalOC and ucOC) were measured before and six months after surgery...
November 3, 2016: Bone
https://www.readbyqxmd.com/read/27808040/endobarrier-gastrointestinal-liner-delineation-of-underlying-mechanisms-and-clinical-effects
#7
Ulrich Rohde
Bariatric surgery (e.g. Roux-en-Y gastric bypass (RYGB)) has proven the most effective way of achieving sustainable weight losses and remission of type 2 diabetes (T2D). Studies indicate that the effectiveness of RYGB is mediated by an altered gastrointestinal tract anatomy, which in particular favours release of the gut incretin hormone glucagon-like peptide-1 (GLP-1). The EndoBarrier gastrointestinal liner or duodenal-jejunal bypass sleeve (DJBS) is an endoscopic deployable minimally invasive and fully reversible technique designed to mimic the bypass component of the RYGB...
November 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27795552/efficacy-and-safety-of-bariatric-surgery-for-craniopharyngioma-related-hypothalamic-obesity-a-matched-case-control-study-with-two-years-of-follow-up
#8
M Wijnen, D S Olsson, M M van den Heuvel-Eibrink, V Wallenius, Jamjl Janssen, P J D Delhanty, A J van der Lely, G Johannsson, Sjcmm Neggers
BACKGROUND: Hypothalamic obesity is a devastating consequence of craniopharyngioma. Bariatric surgery could be a promising therapeutic option. However, its efficacy and safety in patients with craniopharyngioma-related hypothalamic obesity remain largely unknown. OBJECTIVES: We investigated the efficacy of bariatric surgery for inducing weight loss in patients with craniopharyngioma-related hypothalamic obesity. Additionally, we studied the safety of bariatric surgery regarding its effects on hormone replacement therapy for pituitary insufficiency...
October 31, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27773356/polycystic-ovary-syndrome-and-endometrial-hyperplasia-an-overview-of-the-role-of-bariatric-surgery-in-female-fertility
#9
Vasileios Charalampakis, Abd A Tahrani, Ahmed Helmy, Janesh K Gupta, Rishi Singhal
One of the most effective methods to tackle obesity and its related comorbidities is bariatric surgery. Polycystic ovary syndrome (PCOS) and endometrial hyperplasia (EH), which are associated with increased risk of endometrial carcinoma, have been identified as potentially new indications for bariatric surgery. PCOS is the most common endocrine disorder in women in the reproductive age and is associated with several components of the metabolic syndrome such as obesity, insulin resistance and hypertension. EH is a pre-cancerous condition which arises in the presence of chronic exposure to estrogen unopposed by progesterone such as both in PCOS and obesity...
October 17, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27761724/sleeve-gastrectomy-vs-roux-en-y-gastric-bypass-data-from-ifso-european-chapter-center-of-excellence-program
#10
John Melissas, Konstantinos Stavroulakis, Vassilis Tzikoulis, Angeliki Peristeri, John A Papadakis, Abdolreza Pazouki, Alireza Khalaj, Ali Kabir
BACKGROUND: The purpose of this study is to compare sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGBP) performed in Institutions participating in IFSO-European Chapter, Center of Excellence (COE) program. METHODS: Since the initiation of the program in January 2010, 6413 SGs and 10,622 RYGBPs performed as primary procedures by December 31, 2014, with at least 12-month follow-up, were retrospectively compared. RESULTS: There were steadily increasing numbers of patients underwent SG from 2010 to 2015...
October 20, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27730102/outcomes-the-ontario-bariatric-network-a-cohort-study
#11
Fady Saleh, Aristithes G Doumouras, Scott Gmora, Mehran Anvari, Dennis Hong
BACKGROUND: Bariatric surgery centres of excellence are relatively new in Canada and were first started in Ontario in 2009. This study presents short-term outcomes of Canada's largest bariatric collaborative, from Ontario, during its first 3 years. METHODS: We performed a population-based cohort study that included all patients (age ≥ 18) who received a Roux-en-Y gastric bypass or sleeve gastrectomy for the purpose of weight loss from March 2009 to April 2012 within Ontario...
July 2016: CMAJ Open
https://www.readbyqxmd.com/read/27725831/changes-in-testosterone-levels-and-sex-hormone-binding-globulin-levels-in-extremely-obese-men-after-bariatric-surgery
#12
Patchaya Boonchaya-Anant, Nitchakarn Laichuthai, Preaw Suwannasrisuk, Natnicha Houngngam, Suthep Udomsawaengsup, Thiti Snabboon
Objective. Obesity is a risk factor for hypogonadotropic hypogonadism in men. Weight loss has been shown to improve hypogonadism in obese men. This study evaluated the early changes in sex hormones profile after bariatric surgery. Methods. This is a prospective study including 29 morbidly obese men. Main outcomes were changes in serum levels of total testosterone (TT), free testosterone (cFT), SHBG, estradiol, adiponectin, and leptin at 1 and 6 months after surgery. Results. The mean age of patients was 31 ± 8 years and the mean BMI was 56...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27720197/long-term-and-midterm-outcomes-of-laparoscopic-sleeve-gastrectomy-versus-roux-en-y-gastric-bypass-a-systematic-review-and-meta-analysis-of-comparative-studies
#13
Saeed Shoar, Alan A Saber
OBJECTIVE: This study aimed to compare midterm and long-term weight loss and resolution of co-morbidity with laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG). SUMMARY: LRYGB and LSG are the most common procedures performed in bariatric surgery. However, their weight loss efficacy in the midterm and long-term has not been well compared. METHODS: A meta-analysis was performed by systematically identifying comparative studies conducted until the end of June 2016 that investigated weight loss outcome and resolution of co-morbidities (type 2 diabetes mellitus, hypertension, hyperlipidemia, hypertriglyceridemia, and obstructive sleep apnea) with LRYGB and LSG in the midterm (3-5 years) and long term (≥5 years)...
August 18, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27692906/ghrelin-leptin-and-glycemic-control-after-sleeve-gastrectomy-versus-roux-en-y-gastric-bypass-results-of-a-randomized-clinical-trial
#14
Piotr Kalinowski, Rafał Paluszkiewicz, Tadeusz Wróblewski, Piotr Remiszewski, Mariusz Grodzicki, Zbigniew Bartoszewicz, Marek Krawczyk
BACKGROUND: Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) cause weight loss and metabolic improvement, but results of published studies are contradictory. OBJECTIVES: The aim of this study was to compare the effects of SG and RYGB on ghrelin, leptin, and glucose homeostasis in a randomized controlled trial. SETTING: University hospital, Poland. METHODS: Seventy-two morbidly obese patients were randomly selected to undergo either SG (n = 36) or RYGB (n = 36)...
August 18, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27683794/from-complex-evolving-to-simple-current-revisional-and-endoscopic-procedures-following-bariatric-surgery
#15
Ricardo Zorron, Manoel Passos Galvão-Neto, Josemberg Campos, Alcides José Branco, José Sampaio, Tido Junghans, Claudia Bothe, Christian Benzing, Felix Krenzien
Background: Roux-en-Y gastric bypass (RYGB) is a standard therapy in bariatric surgery. Sleeve gastrectomy and gastric banding, although with good results in the literature, are showing higher rates of treatment failure to reduce obesity-associated morbidity and body weight. Other problems after bariatric may occur, as band erosion, gastroesophageal reflux disease and might be refractory to medication. Therefore, a laparoscopic conversion to a RYGB can be an effective alternative, as long as specific indications for revision are fulfilled...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27683788/the-role-of-metabolic-surgery-for-patients-with-obesity-grade-i-and-type-2-diabetes-not-controlled-clinically
#16
Josemberg Campos, Almino Ramos, Thomaz Szego, Bruno Zilberstein, Heládio Feitosa, Ricardo Cohen
Introduction: Even considering the advance of the medical treatment in the last 20 years with new and more effective drugs, the outcomes are still disappointing as the control of obesity and type 2 Diabetes Mellitus (T2DM) with a large number of patients under the medical treatment still not reaching the desired outcomes. Objective: To present a Metabolic Risk Score to better guide the surgical indication for T2DM patients with body mass index (BMI) where surgery for obesity is still controversial...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27671525/physiological-and-molecular-responses-to-bariatric-surgery-markers-or-mechanisms-underlying-t2dm-resolution
#17
Chelsea R Hutch, Darleen A Sandoval
Bariatric surgery is currently the most effective treatment for obesity and associated comorbidities, including rapid resolution of type 2 diabetes mellitus (T2DM). Although the weight loss itself has substantial impact, bariatric surgery also has weight loss-independent effects on T2DM. Several variations of bariatric surgery exist, including the widely studied Roux-en-Y gastric bypass and vertical sleeve gastrectomy. The success of both of these bariatric surgeries was originally attributed to restrictive and malabsorptive modes of action; however, mounting evidence from both human and animal studies implicates mechanisms beyond surgery-induced mechanical changes to the gastrointestinal (GI) system...
September 26, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27652359/primary-experience-of-bariatric-surgery-in-a-newly-established-private-obesity-center
#18
Haider Al-Shurafa, Ahmed H Elzaafarany, Ali Albenmousa, Mona G Balata
OBJECTIVES: To assess the outcomes of different types of bariatric surgeries in a single newly established private obesity center. METHODS: Retrospectively, we included patients who were entered in the registry for bariatric surgeries in the Obesity Unit, Riyadh National Hospital, Riyadh, Saudi Arabia between January 2013 and September 2014, and completed one year of follow up. Baseline characteristics, percent excess weight loss, and safety data were collected and analyzed...
October 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27644433/five-year-results-of-laparoscopic-sleeve-gastrectomy-with-duodenojejunal-bypass-for-weight-loss-and-type-2-diabetes-mellitus
#19
Yosuke Seki, Kazunori Kasama, Hidenori Haruta, Atsushi Watanabe, Renzo Yokoyama, Jose Paolo Cabreira Porciuncula, Akiko Umezawa, Yoshimochi Kurokawa
BACKGROUND: Laparoscopic sleeve gastrectomy with duodenojejunal bypass (LSG-DJB) has been designated as a novel bariatric surgery procedure. This combination of sleeve gastrectomy and proximal intestinal bypass theoretically offers an effective and prolonged anti-diabetes effect. This is a follow-up of our institution's previous report on the short-term effects of LSG-DJB on type 2 diabetes mellitus (T2DM), which a 68.7 % remission (HbA1c <6 % without diabetes medication) rate 1 year after surgery...
September 19, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27583422/update-on-office-based-strategies-for-the-management-of-obesity
#20
Michael Erlandson, Laurie C Ivey, Katie Seikel
Obesity is a common condition that is associated with numerous medical problems such as cardiovascular disease, pulmonary disease, and diabetes mellitus. Primary care physicians have an important role in helping patients develop a successful weight loss plan to improve their overall health. Dietary strategies emphasizing reduced caloric intake, regardless of the nutrient composition, are important for weight loss. Behavioral interventions such as motivational interviewing and encouraging physical activity lead to additional weight loss when combined with dietary changes...
September 1, 2016: American Family Physician
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