keyword
https://read.qxmd.com/read/38521185/glp-1r-signaling-modulates-colonic-energy-metabolism-goblet-cell-number-and-survival-in-the-absence-of-gut-microbiota
#21
JOURNAL ARTICLE
Thomas U Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E V Johansson, Gunnar C Hansson, Daniel J Drucker, Fredrik Bäckhed
OBJECTIVE: Theut microbiota increases energy availability through fermentation of dietary fibers to short-chain fatty acids in conventionally raised mice. Energy deficiency in germ-free (GF) mice increases glucagon-like peptide-1 (GLP-1) levels, which slows intestinal transit. To further analyze the role of GLP-1-mediated signaling in this model of energy deficiency, we re-derived mice lacking GLP-1 receptor (GLP-1R KO) as GF. METHODS: GLP-1R KO mice were rederived as GF through hysterectomy and monitored for 30 weeks...
March 21, 2024: Molecular Metabolism
https://read.qxmd.com/read/38521168/poly-d-l-lactide-co-glycolide-particles-are-metabolised-by-the-gut-microbiome-and-elevate-short-chain-fatty-acids
#22
JOURNAL ARTICLE
Laura E McCoubrey, Fabiana Ferraro, Nidhi Seegobin, Jérémy Verin, Haya A Alfassam, Atheer Awad, Massimo Marzorati, Lynn Verstrepen, Jonas Ghyselinck, Julie De Munck, Jelle De Medts, Evi Steppe, Valerie De Vleeschhauwer, Gilles De Rocker, Alexandra Droesbeke, Melanie De Rijck, Sara Vanthoor, Frédéric Moens, Juergen Siepmann, Florence Siepmann, Simon Gaisford, Mine Orlu, Abdul W Basit
The production of short chain fatty acids (SCFAs) by the colonic microbiome has numerous benefits for human health, including maintenance of epithelial barrier function, suppression of colitis, and protection against carcinogenesis. Despite the therapeutic potential, there is currently no optimal approach for elevating the colonic microbiome's synthesis of SCFAs. In this study, poly(D,l-lactide-co-glycolide) (PLGA) was investigated for this application, as it was hypothesised that the colonic microbiota would metabolise PLGA to its lactate monomers, which would promote the resident microbiota's synthesis of SCFAs...
March 21, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38520936/effect-of-replacing-soybean-meal-with-hermetia-illucens-meal-on-cecal-microbiota-liver-transcriptome-and-plasma-metabolome-of-broilers
#23
JOURNAL ARTICLE
Simone Beller, Sarah M Grundmann, Klara Pies, Erika Most, Sven Schuchardt, Waldemar Seel, Marie-Christine Simon, Klaus Eder, Robert Ringseis
Despite the existence of a number of studies investigating the effect of insect meal on the growth performance of broilers, knowledge about the metabolic effects of insect meal in broilers is still scarce. Thus, the present study investigated the effect of partial replacement of soybean meal with Hermetia illucens (HI) larvae meal on the liver transcriptome, the plasma metabolome, and the cecal microbiota in broilers. For the study, 72 male one-day-old Cobb 500 broilers were divided into three groups and fed 3 different diets with either 0% (HI0), 7...
March 8, 2024: Poultry Science
https://read.qxmd.com/read/38520351/exopolysaccharides-produced-by-bifidobacterium-longum-subsp-longum-ys108r-ameliorates-dss-induced-ulcerative-colitis-in-mice-by-improving-the-gut-barrier-and-regulating-the-gut-microbiota
#24
JOURNAL ARTICLE
Huizhen Li, Haitao Li, Catherine Stanton, R Paul Ross, Jianxin Zhao, Wei Chen, Bo Yang
Ulcerative colitis (UC) is a major disease that has endangered human health. Our previous study demonstrated that Bifidobacterium longum subsp. longum YS108R, a ropy exopolysaccharide (EPS)-producing bacterium, could alleviate UC in mice, but it is unclear whether EPS is the key substance responsible for its action. In this study, we proposed to investigate the remitting effect of EPS from B. longum subsp. longum YS108R on UC in a DSS-induced UC mouse model. Water extraction and alcohol precipitation were applied to extract EPS from the supernatant of B...
March 23, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38520258/structural-characterization-of-a-novel-polysaccharide-from-tremella-fuciformis-and-its-interaction-with-gut-microbiota
#25
JOURNAL ARTICLE
Haizhao Song, Jing Lu, Qiang Chu, Rou Deng, Xinchun Shen
BACKGROUND: Due to their diverse biological activities, polysaccharides derived from Tremella fuciformis have received growing attention. This study aimed to investigate the structural characterization of a purified polysaccharide (designated as PTP-3a) derived from Tremella fuciformis and explore its interaction with gut microbiota in vitro. RESULTS: The findings revealed that PTP-3a had a molecular weight of 1.22 × 103  kDa and consisted of fucose, glucose, xylose, mannose, and glucuronic acid in a molar ratio of 0...
March 23, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38519184/food-additives-impair-gut-microbiota-from-healthy-individuals-and-ibd-patients-in-a-colonic-in-vitro-fermentation-model
#26
JOURNAL ARTICLE
Irma Gonza, Elizabeth Goya-Jorge, Caroline Douny, Samiha Boutaleb, Bernard Taminiau, Georges Daube, Marie-Louise Scippo, Edouard Louis, Véronique Delcenserie
Intestinal fibrosis is a long-term complication of inflammatory bowel diseases (IBD). Changes in microbial populations have been linked with the onset of fibrosis and some food additives are known to promote intestinal inflammation facilitating fibrosis induction. In this study, we investigated how polysorbate 80, sucralose, titanium dioxide, sodium nitrite and maltodextrin affect the gut microbiota and the metabolic activity in healthy and IBD donors (patients in remission and with a flare of IBD). The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) with a static (batch) configuration was used to evaluate the effects of food additives on the human intestinal microbiota...
April 2024: Food Research International
https://read.qxmd.com/read/38519176/in-vitro-protein-digestion-and-carbohydrate-colon-fermentation-of-microbial-biomass-samples-from-bacterial-filamentous-fungus-and-yeast-sources
#27
JOURNAL ARTICLE
Nordlund Emilia, Silventoinen-Veijalainen Pia, Hyytiäinen-Pabst Tiina, Nyyssölä Antti, Valtonen Anniina, Ritala Anneli, Lienemann Michael, Rosa-Sibakov Natalia
This study evaluated the nutritional quality of different microbial biomass samples by assessing their protein digestibility and carbohydrate fermentability in the colon using in vitro methods. Four microbial samples were produced: one hydrogen-oxidizing bacterial strain (Nocardioides nitrophenolicus KGS-27), two strains of filamentous fungi (Rhizopus oligosporus and Paecilomyces variotii), and one yeast strain (Rhodotorula babjevae). The microorganisms were grown in bioreactors, harvested and dried before analysis...
April 2024: Food Research International
https://read.qxmd.com/read/38518247/influence-of-angiotensin-ii-on-the-gut-microbiome-modest-effects-in-comparison-to-experimental-factors
#28
JOURNAL ARTICLE
Rikeish R Muralitharan, Michael E Nakai, Matthew Snelson, Tenghao Zheng, Evany Dinakis, Liang Xie, Hamdi Jama, Madeleine Paterson, Waled Shihata, Flavia Wassef, Antony Vinh, Grant R Drummond, David M Kaye, Charles R Mackay, Francine Z Marques
INTRODUCTION: Animal models are regularly used to test the role of the gut microbiome in hypertension. Small-scale pre-clinical studies have investigated changes to the gut microbiome in the angiotensin II hypertensive model. However, the gut microbiome is influenced by internal and external experimental factors which are not regularly considered in the study design. Once these factors are accounted for, it is unclear if microbiome signatures are reproduceable. We aimed to determine the influence of angiotensin II treatment on the gut microbiome using a large and diverse cohort of mice and to quantify the magnitude by which other factors contribute to microbiome variations...
March 22, 2024: Cardiovascular Research
https://read.qxmd.com/read/38517169/design-of-a-proteolytic-module-for-improved-metabolic-modeling-of-bacteroides-caccae
#29
JOURNAL ARTICLE
Amandine Paulay, Ghjuvan M Grimaud, Raphaël Caballero, Béatrice Laroche, Marion Leclerc, Simon Labarthe, Emmanuelle Maguin
The gut microbiota plays a crucial role in health and is significantly modulated by human diets. In addition to Western diets which are rich in proteins, high-protein diets are used for specific populations or indications, mainly weight loss. In this study, we investigated the effect of protein supplementation on Bacteroides caccae , a Gram-negative gut symbiont. The supplementation with whey proteins led to a significant increase in growth rate, final biomass, and short-chain fatty acids production. A comprehensive genomic analysis revealed that B...
March 22, 2024: MSystems
https://read.qxmd.com/read/38516317/functional-contribution-of-the-intestinal-microbiome-in-autism-spectrum-disorder-attention-deficit-hyperactivity-disorder-and-rett-syndrome-a-systematic-review-of-pediatric-and-adult-studies
#30
Valentina Caputi, Lee Hill, Melanie Figueiredo, Jelena Popov, Emily Hartung, Kara Gross Margolis, Kanish Baskaran, Papiha Joharapurkar, Michal Moshkovich, Nikhil Pai
INTRODUCTION: Critical phases of neurodevelopment and gut microbiota diversification occur in early life and both processes are impacted by genetic and environmental factors. Recent studies have shown the presence of gut microbiota alterations in neurodevelopmental disorders. Here we performed a systematic review of alterations of the intestinal microbiota composition and function in pediatric and adult patients affected by autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and Rett syndrome (RETT)...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38516012/association-between-gut-microbiota-and-hirschsprung-disease-a-bidirectional-two-sample-mendelian-randomization-study
#31
JOURNAL ARTICLE
Wei Liu, Hanlei Yan, Wanying Jia, Jingjing Huang, Zihao Fu, Wenyao Xu, Hui Yu, Weili Yang, Weikang Pan, Baijun Zheng, Yong Liu, Xinlin Chen, Ya Gao, Donghao Tian
BACKGROUND: Several studies have pointed to the critical role of gut microbiota (GM) and their metabolites in Hirschsprung disease (HSCR) pathogenesis. However, the detailed causal relationship between GM and HSCR remains unknown. METHODS: In this study, we used two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between GM and HSCR, based on the MiBioGen Consortium's genome-wide association study (GWAS) and the GWAS Catalog's HSCR data...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38514862/gpr41-deficiency-aggravates-type-1-diabetes-in-streptozotocin-treated-mice-by-promoting-dendritic-cell-maturation
#32
JOURNAL ARTICLE
Jia-Hong Li, Ming Zhang, Zhao-di Zhang, Xiao-Hua Pan, Li-Long Pan, Jia Sun
Disturbances in intestinal immune homeostasis predispose susceptible individuals to type 1 diabetes (T1D). G-protein-coupled receptor 41 (GPR41) is a receptor for short-chain fatty acids (SCFAs) mainly produced by gut microbiota, which plays key roles in maintaining intestinal homeostasis. In this study, we investigated the role of GPR41 in the progression of T1D. In non-obese diabetic (NOD) mice, we found that aberrant reduction of GPR41 expression in the pancreas and colons was associated with the development of T1D...
March 21, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38514648/integrative-metagenomic-and-metabolomic-analyses-reveal-the-potential-of-gut-microbiota-to-exacerbate-acute-pancreatitis
#33
JOURNAL ARTICLE
Jianjun Liu, Qiulong Yan, Shenghui Li, Juying Jiao, Yiming Hao, Guixin Zhang, Qingkai Zhang, Fei Luo, Yue Zhang, Qingbo Lv, Wenzhe Zhang, Aiqin Zhang, Huiyi Song, Yi Xin, Yufang Ma, Lawrence Owusu, Xiaochi Ma, Peiyuan Yin, Dong Shang
Early dysbiosis in the gut microbiota may contribute to the severity of acute pancreatitis (AP), however, a comprehensive understanding of the gut microbiome, potential pathobionts, and host metabolome in individuals with AP remains elusive. Hence, we employed fecal whole-metagenome shotgun sequencing in 82 AP patients and 115 matched healthy controls, complemented by untargeted serum metabolome and lipidome profiling in a subset of participants. Analyses of the gut microbiome in AP patients revealed reduced diversity, disrupted microbial functions, and altered abundance of 77 species, influenced by both etiology and severity...
March 21, 2024: NPJ Biofilms and Microbiomes
https://read.qxmd.com/read/38513460/short-chain-fatty-acids-modulate-the-ipec-j2-cell-response-to-pathogenic-e-coli-lps-activated-pbmc
#34
JOURNAL ARTICLE
Melania Andrani, Luca Ferrari, Paolo Borghetti, Valeria Cavalli, Elena De Angelis, Francesca Ravanetti, Eleonora Dall'Olio, Paolo Martelli, Roberta Saleri
Intestinal disorders can affect pigs of any age, especially when animals are young and more susceptible to infections and environmental stressors. For instance, pathogenic E. coli can alter intestinal functions, thus leading to altered nutrient adsorption by interacting with local cells through lipopolysaccharide (LPS). Among several compounds studied to counteract the negative effects on the intestine, short-chain fatty acids (SCFA) were demonstrated to exert beneficial effects on gut epithelial cells and resident immune cells...
March 16, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38513377/gut-microbiota-dependent-modulation-of-pre-metastatic-niches-by-jianpi-yangzheng-decoction-in-the-prevention-of-lung-metastasis-of-gastric-cancer
#35
JOURNAL ARTICLE
Xiaofei Zhu, Xingxing Zhang, Junyu Shen, Shanshan Zheng, Huaizhi Li, Bo Han, Cancan Zhang, Menglin Chen, Qingmin Sun, Jian Wu
AIM OF THE STUDY: To evaluate the in vitro and in vivo anti-metastasis efficacy of Jianpi Yangzheng (JPYZ) decoction against gastric cancer (GC) and its potential mechanisms. MATERIALS AND METHODS: The distant metastasis of GC cells administered via tail vein injection was assessed using the pre-metastatic niche (PMN) model. 16S rRNA sequencing and GC-MS/MS were applied to determine the component of the gut microbiota and content of short-chain fatty acids (SCFAs) in feces of mice, respectively...
February 4, 2024: Phytomedicine
https://read.qxmd.com/read/38513356/harnessing-the-power-within-engineering-the-microbiome-for-enhanced-gynecologic-health
#36
JOURNAL ARTICLE
Caitriona Brennan, Kristina Chan, Tanya Kumar, Erica Maissy, Linda Brubaker, Marisol I Dothard, Jack A Gilbert, Katharine E Gilbert, Amanda L Lewis, Varykina Thackray, Amir Zarrinpar, Rob Knight
Although numerous studies have demonstrated the impact of microbiome manipulation on human health, research on the microbiome's influence on female health remains relatively limited despite substantial disease burden. In light of this, we present a selected review of clinical trials and preclinical studies targeting both the vaginal and gut microbiome for the prevention or treatment of various gynecologic conditions. Specifically, we explore studies that leverage microbiota transplants, probiotics, prebiotics, diet modifications, and engineered microbial strains...
March 1, 2024: Reproduction & fertility
https://read.qxmd.com/read/38511344/mannan-oligosaccharides-promote-gut-microecological-recovery-after-antibiotic-disturbance
#37
JOURNAL ARTICLE
Jing Chen, Jialin Yin, Heqiang Xie, Wenwei Lu, Hongchao Wang, Jianxin Zhao, Jinlin Zhu
Antibiotic treatment often causes collateral damage to the gut microbiota, including changes in its diversity and composition. Dietary fiber helps maintain intestinal health, regulate short-chain fatty acids, and promote the recovery of the intestinal microbiome. However, it is currently unknown which specific plant-based dietary fiber is optimal as a dietary supplement for restoring the intestinal microbiota after antibiotic disturbance. Previously, we proposed predictive recovery-associated bacterial species (p-RABs) and identified the most important interventions...
March 21, 2024: Food & Function
https://read.qxmd.com/read/38511260/an-exopolysaccharide-from-genistein-stimulated-monascus-purpureus-structural-characterization-and-protective-effects-against-dss-induced-intestinal-barrier-injury-associated-with-the-gut-microbiota-modulated-short-chain-fatty-acid-tlr4-mapk-nf-%C3%AE%C2%BAb-cascade-response
#38
JOURNAL ARTICLE
Liuming Xie, Ting Chen, Hong Li, Jindan Xiao, Linchun Wang, Soo-Ki Kim, Zhibing Huang, Jianhua Xie
Inflammatory bowel disease is a major health problem that can lead to prolonged damage to the digestive system. This study investigated the effects of an exopolysaccharide from genistein-stimulated Monascus purpureus (G-EMP) in a mouse model of colitis to clarify its molecular mechanisms and identified its structures. G-EMP ( Mw = 56.4 kDa) was primarily consisted of → 4)-α-D-Gal p -(1 →, → 2,6)-α-D-Glc p -(1→ and →2)-β-D-Man p -(1 → , with one of the branches being α-D-Manp-(1 →...
March 21, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38510960/signatures-of-disease-outcome-severity-in-the-intestinal-fungal-and-bacterial-microbiome-of-covid-19-patients
#39
JOURNAL ARTICLE
Fernando Rizzello, Elisa Viciani, Paolo Gionchetti, Eleonora Filippone, Veronica Imbesi, Laura Melotti, Nikolas Konstantine Dussias, Marco Salice, Barbara Santacroce, Antonella Padella, Alena Velichevskaya, Andrea Marcante, Andrea Castagnetti
BACKGROUND: COVID-19, whose causative pathogen is the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic in March 2020. The gastrointestinal tract is one of the targets of this virus, and mounting evidence suggests that gastrointestinal symptoms may contribute to disease severity. The gut-lung axis is involved in the immune response to SARS-CoV-2; therefore, we investigated whether COVID-19 patients' bacterial and fungal gut microbiome composition was linked to disease clinical outcome...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38509226/patterns-of-infant-fecal-metabolite-concentrations-and-social-behavioral-development-in-toddlers
#40
JOURNAL ARTICLE
Hannah E Laue, Julia A Bauer, Wimal Pathmasiri, Susan C J Sumner, Susan McRitchie, Thomas J Palys, Anne G Hoen, Juliette C Madan, Margaret R Karagas
BACKGROUND: Gut-derived metabolites, products of microbial and host co-metabolism, may inform mechanisms underlying children's neurodevelopment. We investigated whether infant fecal metabolites were related to toddler social behavior. METHODS: Stool samples collected from 6-week-olds (n = 86) and 1-year-olds (n = 209) in the New Hampshire Birth Cohort Study (NHBCS) were analyzed using nuclear magnetic resonance spectroscopy metabolomics...
March 20, 2024: Pediatric Research
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