keyword
MENU ▼
Read by QxMD icon Read
search

Short chain fatty acids

keyword
https://www.readbyqxmd.com/read/28718839/dose-dependent-prebiotic-effect-of-lactulose-in-a-computer-controlled-in-vitro-model-of-the-human-large-intestine
#1
Melanie K Bothe, Annet J H Maathuis, Susann Bellmann, Jos M B M van der Vossen, Dirk Berressem, Annalena Koehler, Susann Schwejda-Guettes, Barbara Gaigg, Angelika Kuchinka-Koch, John F Stover
Lactulose, a disaccharide of galactose and fructose, used as a laxative or ammonia-lowering drug and as a functional food ingredient, enhances growth of Bifidobacterium and Lactobacillus at clinically relevant dosages. The prebiotic effect of subclinical dosages of Lactulose, however, remains to be elucidated. This study analyses changes in the microbiota and their metabolites after a 5 days Lactulose treatment using the TIM-2 system, a computer-controlled model of the proximal large intestine representing a complex, high density, metabolically active, anaerobic microbiota of human origin...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28717897/development-of-a-fast-and-cost-effective-gas-chromatography-mass-spectrometry-method-for-the-quantification-of-short-chain-and-medium-chain-fatty-acids-in-human-biofluids
#2
Cesare Lotti, Josep Rubert, Francesca Fava, Kieran Tuohy, Fulvio Mattivi, Urska Vrhovsek
The quantification of short-chain and medium-chain fatty acids is becoming more and more relevant in fecal and plasma samples due to their biological impact, which has been associated with colon rectal cancer and fiber consumption. For these reasons, a fast, cost-effective, and reproducible analytical method is highly required. In this research, a gas chromatography-mass spectrometry method based on full scan and multiple reaction monitoring (MRM) acquisition modes were optimized and validated for the analysis of short-chain and medium-chain fatty acids in three biological samples: human fecal water, fecal fermentation supernatants, and human plasma...
July 17, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28714277/free-fatty-acid-receptor-3-activation-suppresses-neurogenic-motility-in-rat-proximal-colon
#3
I Kaji, Y Akiba, T Furuyama, D W Adelson, K Iwamoto, M Watanabe, A Kuwahara, J D Kaunitz
BACKGROUND: Short-chain fatty acids (SCFA) are microbial fermentation products absorbed by the colon. We recently reported that activation of the SCFA receptor termed free fatty acid receptor 3 (FFA3), expressed on cholinergic nerves, suppresses nicotinic acetylcholine receptor (nAChR)-mediated transepithelial anion secretion. This study aimed to clarify how activation of neurally expressed FFA3 affects colonic motor function. METHODS: FFA3-expressing myenteric neurons were identified by immunostaining; contractions of isolated circular muscle strips obtained from rat proximal colon were measured by isometric transducers...
July 17, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28713353/functional-characterization-of-novel-faecalibacterium-prausnitzii-strains-isolated-from-healthy-volunteers-a-step-forward-in-the-use-of-f-prausnitzii-as-a-next-generation-probiotic
#4
Rebeca Martín, Sylvie Miquel, Leandro Benevides, Chantal Bridonneau, Véronique Robert, Sylvie Hudault, Florian Chain, Olivier Berteau, Vasco Azevedo, Jean M Chatel, Harry Sokol, Luis G Bermúdez-Humarán, Muriel Thomas, Philippe Langella
Faecalibacterium prausnitzii is a major member of the Firmicutes phylum and one of the most abundant bacteria in the healthy human microbiota. F. prausnitzii depletion has been reported in several intestinal disorders, and more consistently in Crohn's disease (CD) patients. Despite its importance in human health, only few microbiological studies have been performed to isolate novel F. prausnitzii strains in order to better understand the biodiversity and physiological diversity of this beneficial commensal species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28713165/fatty-is-not-that-bad-feeding-short-chain-fatty-acids-to-restrain-autoimmunity
#5
Arianna Brevi, Matteo Bellone
No abstract text is available yet for this article.
July 17, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28713163/microbiota-or-short-chain-fatty-acids-which-regulates-diabetes
#6
Chang H Kim
No abstract text is available yet for this article.
July 17, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28711599/arachidonic-acid-sex-dependently-affects-obesity-through-linking-gut-microbiota-driven-inflammation-to-hypothalamus-adipose-liver-axis
#7
Pan Zhuang, Qiyang Shou, Yanhua Lu, Guangfa Wang, Jieni Qiu, Jun Wang, Lilin He, Jingnan Chen, Jingjing Jiao, Yu Zhang
Unraveling the role of dietary lipids is beneficial to treat obesity and metabolic dysfunction. Nonetheless, how dietary lipids affect existing obesity remains unknown. Arachidonic acid (AA), a derivative of linoleic acid, is one of the crucial n-6 fatty acids. The aim of this study was to investigate whether AA affects obesity through associating microbiota-driven inflammation with hypothalamus-adipose-liver axis. Four-week old C57BL/6J mice were fed with a high-fat diet (HFD, 45% fat) for 10 weeks to induce obesity, and then fed a HFD enriched with 10 g/kg of AA or a continuous HFD in the following 15 weeks...
July 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28711265/feeding-a-concentrate-rich-in-rapeseed-oil-improves-fatty-acid-composition-and-flavor-in-norwegian-goat-milk
#8
R A Inglingstad, S Skeie, G E Vegarud, T G Devold, Y Chilliard, M Eknæs
Impaired quality due to a high content of free fatty acids (FFA) and off-flavors has caused challenges in the development of Norwegian goat milk products. The present study aimed to examine the effect of lipid-supplemented concentrates on milk fat content, fatty acid composition, FFA, lipoprotein lipase activity, sensory properties, and size of milk fat globules of goat milk. Thirty goats assigned to 3 experimental groups were fed different concentrates from 60 d in milk (DIM) until late lactation (230 DIM)...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28710833/effect-of-cellobiose-supplementation-on-in-vitro-fermentation-activity-and-bacterial-numbers-of-porcine-inocula
#9
S N Heinritz, E Weiss, J Seifert, R Mosenthin, S Kuß, A G Degenhardt, T J Koch
In this in vitro study, the modified Hohenheim gas test (HGT) was applied to determine fermentation activity and bacterial composition of pig's faecal microbial inoculum using different concentrations of cellobiose. Incubation procedures included normal buffered and osmotic stress conditions (elevated medium salinity). After 24 hr of fermentation, production of gas, ammonia and short-chain fatty acid (SCFA) was measured, and the gene copy numbers of total bacteria, Lactobacillus spp., Bifidobacterium spp., Roseburia spp...
July 15, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28709472/potential-and-active-functions-in-the-gut-microbiota-of-a-healthy-human-cohort
#10
Alessandro Tanca, Marcello Abbondio, Antonio Palomba, Cristina Fraumene, Valeria Manghina, Francesco Cucca, Edoardo Fiorillo, Sergio Uzzau
BACKGROUND: The study of the gut microbiota (GM) is rapidly moving towards its functional characterization by means of shotgun meta-omics. In this context, there is still no consensus on which microbial functions are consistently and constitutively expressed in the human gut in physiological conditions. Here, we selected a cohort of 15 healthy subjects from a native and highly monitored Sardinian population and analyzed their GMs using shotgun metaproteomics, with the aim of investigating GM functions actually expressed in a healthy human population...
July 14, 2017: Microbiome
https://www.readbyqxmd.com/read/28707415/effect-of-ginkgo-extract-supplementation-on-in%C3%A2-vitro-rumen-fermentation-and-bacterial-profiles-under-different-dietary-conditions
#11
Seongjin Oh, Satoshi Koike, Yasuo Kobayashi
Ginkgo extract was applied to a batch culture study and evaluated for its potential as a feed additive for ruminant animals under different forage-to-concentrate (F:C) ratios (1:9, 3:7, 5:5, 7:3 and 9:1). Rumen fluid was mixed with respective diet and incubated at 39°C for 24 h with and without ginkgo extract (1.6% fruit equivalent in culture). Methane production was significantly decreased by ginkgo extract, with the greatest reductions found in the 5:5 (41.9%) followed by the 7:3 ratios (36.7%). Total short chain fatty acid and ammonia levels were not affected by ginkgo extract supplementation in any of the five different diets...
July 14, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28705738/identification-of-novel-potential-scaffold-for-class-i-hdacs-inhibition-an-in-silico-protocol-based-on-virtual-screening-molecular-dynamics-mathematical-analysis-and-machine-learning
#12
Cong Fan, Yanxin Huang
Histone deacetylases (HDACs) family has been widely reported as an important class of enzyme targets for cancer therapy. Much effort has been made in discovery of novel scaffolds for HDACs inhibition besides existing hydroxamic acids, cyclic peptides, benzamides, and short-chain fatty acids. Herein we set up an in-silico protocol which not only could detect potential Zn(2+) chelation bonds but also still adopted non-bonded model to be effective in discovery of Class I HDACs inhibitors, with little human's subjective visual judgment involved...
July 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28704610/effects-of-medium-and-long-chain-triacylglycerols-on-lipid-metabolism-and-gut-microbiota-composition-in-c57bl-6j-mice
#13
Shengmin Zhou, Yueqiang Wang, Jörg Jacoby, Yuanrong Jiang, Yaqiong Zhang, Liangli Lucy Yu
Obesity is related to an increasing risk of chronic diseases. Medium- and long-chain triacylglycerols (MLCT) have been recognized as a promising choice to reduce body weight. In this study, three MLCT with different contents of medium-chain fatty acids (MCFA) (10%-30%, w/w) were prepared, and their effects on lipid metabolism and fecal gut microbiota composition of C57BL/6J mice were systematically investigated. MLCT with 30% (w/w) MCFA showed the best performance in decreasing body weight gain as well as optimizing serum lipid parameters and liver triacylglycerol content...
July 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28700670/taurine-does-not-affect-the-composition-diversity-or-metabolism-of-human-colonic-microbiota-simulated-in-a-single-batch-fermentation-system
#14
Kengo Sasaki, Daisuke Sasaki, Naoko Okai, Kosei Tanaka, Ryohei Nomoto, Itsuko Fukuda, Ken-Ichi Yoshida, Akihiko Kondo, Ro Osawa
Accumulating evidence suggests that dietary taurine (2-aminoethanesulfonic acid) exerts beneficial anti-inflammatory effects in the large intestine. In this study, we investigated the possible impact of taurine on human colonic microbiota using our single-batch fermentation system (Kobe University Human Intestinal Microbiota Model; KUHIMM). Fecal samples from eight humans were individually cultivated with and without taurine in the KUHIMM. The results showed that taurine remained largely undegraded after 30 h of culturing in the absence of oxygen, although some 83% of the taurine was degraded after 30 h of culturing under aerobic conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28698079/purification-and-fermentation-characteristics-of-exopolysaccharide-from-fomitopsis-castaneus-imaz
#15
Guo Wen-Kui, Chi Yu-Jie
Short-chain fatty acids (SCFAs), which are the end products of carbohydrate fermentation in the gut, mainly contribute to energy metabolism in mammals. The amount of SCFAs produced during fermentation is an important parameter that characterizes the fermentation capacity of a system. This paper reports on the fermentation characteristics of exopolysaccharides (EPS) isolated from Fomitopsis castaneus Imaz, a wood-rot fungal species. We isolated and purified the main EPS fraction by freeze drying and DEAE-Sepharose fast flow chromatography...
July 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28696987/nutritional-supplements-for-the-treatment-and-prevention-of-sports-related-concussion-evidence-still-lacking
#16
Thomas H Trojian, David H Wang, John J Leddy
Concussions are common neurologic events that affect many athletes. Very little has been studied on the treatment of concussions with supplements and medications. The U.S. Food and Drug Administration (FDA) reminds us that no supplement has been proven to treat concussions. Many animal studies show that supplements have potential for improving the effects of a brain injury but none have been shown to be of consistent benefit in human studies. Animal studies on severe traumatic brain injury (TBI) may not therefore be applicable transfer to sports-related concussions (SRC)...
July 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28696379/obesity-and-asthma-a-missing-link
#17
REVIEW
Mª Amelia Gomez-Llorente, Raquel Romero, Natalia Chueca, Ana Martinez-Cañavate, Carolina Gomez-Llorente
Obesity and asthma are two chronic conditions that affect millions of people. Genetic and lifestyle factors such as diet, physical activity, and early exposure to micro-organisms are important factors that may contribute to the escalating prevalence of both conditions. The prevalence of asthma is higher in obese individuals. Recently, two major phenotypes of asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity, and a second phenotype of later-onset asthma that predominantly affects women...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28693612/genome-resolved-metaproteomic-characterization-of-preterm-infant-gut-microbiota-development-reveals-species-specific-metabolic-shifts-and-variabilities-during-early-life
#18
Weili Xiong, Christopher T Brown, Michael J Morowitz, Jillian F Banfield, Robert L Hettich
BACKGROUND: Establishment of the human gut microbiota begins at birth. This early-life microbiota development can impact host physiology during infancy and even across an entire life span. However, the functional stability and population structure of the gut microbiota during initial colonization remain poorly understood. Metaproteomics is an emerging technology for the large-scale characterization of metabolic functions in complex microbial communities (gut microbiota). RESULTS: We applied a metagenome-informed metaproteomic approach to study the temporal and inter-individual differences of metabolic functions during microbial colonization of preterm human infants' gut...
July 10, 2017: Microbiome
https://www.readbyqxmd.com/read/28692672/the-short-chain-fatty-acid-receptor-gpr43-regulates-inflammatory-signals-in-adipose-tissue-m2-type-macrophages
#19
Akira Nakajima, Akiho Nakatani, Sae Hasegawa, Junichiro Irie, Kentaro Ozawa, Gozoh Tsujimoto, Takayoshi Suganami, Hiroshi Itoh, Ikuo Kimura
The regulation of inflammatory responses within adipose tissue by various types of immune cells is closely related to tissue homeostasis and progression of metabolic disorders such as obesity and type 2 diabetes. G-protein-coupled receptor 43 (GPR43), which is activated by short-chain fatty acids (SCFAs), is known to be most abundantly expressed in white adipose tissue and to modulate metabolic processes. Although GPR43 is also expressed in a wide variety of immune cells, whether and how GPR43 in adipose tissue immune cells regulates the inflammatory responses and metabolic homeostasis remains unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28692261/high-antioxidant-action-and-prebiotic-activity-of-hydrolyzed-spent-coffee-grounds-hscg-in-a-simulated-digestion-fermentation-model-toward-the-development-of-a-novel-food-supplement
#20
Lucia Panzella, Sergio Pérez-Burillo, Silvia Pastoriza, María Angeles Martín, Pierfrancesco Cerruti, Luis Goya, Sonia Ramos, José A Rufián-Henares, Alessandra Napolitano, Marco d'Ischia
Spent coffee grounds are a by-product with a large production all over the world. The aim of this study was to explore the effects of a simulated digestion-fermentation treatment on hydrolyzed spent coffee grounds (HSCG) and to investigate the antioxidant properties of the digestion and fermentation products in human hepatocellular carcinoma HepG2 cell line. The potentially bioaccessible (soluble) fractions exhibited high chemoprotective activity in HepG2 cells against oxidative stress. Structural analysis of both the indigestible (insoluble) and soluble material revealed partial hydrolysis and release of the lignin components in the potentially bioaccessible fraction following simulated digestion-fermentation...
July 10, 2017: Journal of Agricultural and Food Chemistry
keyword
keyword
24232
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"