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https://www.readbyqxmd.com/read/29329996/to-prep-or-not-to-prep-that-is-the-question-a-randomized-trial-on-the-use-of-antiflatulent-medication-as-part-of-bowel-preparation-for-patients-having-image-guided-external-beam-radiation-therapy-to-the-prostate
#1
Merrylee McGuffin, Naila Devji, Lyann Kehoe, Anne Carty, Steve Russell, Lisa Di Prospero, Carlo DeAngelis, Alex Kiss, Danny Vesprini, Andrew Loblaw, Laura D'Alimonte
INTRODUCTION: Radiation therapy is a standard treatment option for prostate cancer. With growing use of escalated doses and tighter margins, procedures to limit rectal size variation are needed to reduce prostate motion, increase treatment accuracy, and minimize rectal toxicity. This prospective study was done to determine whether the introduction of an antiflatulent medication would decrease rectal distention at computed tomography (CT) simulation and throughout a course of radiation therapy...
November 4, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29320574/acceleration-of-small-bowel-motility-after-oral-administration-of-dai-kenchu-to-tj-100-assessed-by-cine-magnetic-resonance-imaging
#2
Akitoshi Inoue, Akira Furukawa, Hiroshi Yamamoto, Shinichi Ohta, Nguyen Dai Hung Linh, Tulyeubai Syerikjan, Sachiko Kaida, Tsuyoshi Yamaguchi, Satoshi Murata, Toru Obata, Masaji Tani, Kiyoshi Murata
Dai-kenchu-to (TJ-100) is an herbal medicine used to shorten the duration of intestinal transit by accelerating intestinal movement. However, intestinal movement in itself has not been evaluated in healthy volunteers using radiography, fluoroscopy, and radioisotopes because of exposure to ionizing radiation. The purpose of this study was to evaluate the effect of TJ-100 on intestinal motility using cinematic magnetic resonance imaging (cine MRI) with a steady-state free precession sequence. Ten healthy male volunteers received 5 g of either TJ-100 or lactose without disclosure of the identity of the substance...
2018: PloS One
https://www.readbyqxmd.com/read/29310978/bowel-and-urinary-quality-of-life-after-whole-pelvic-versus-prostate-only-volumetric-modulated-arc-therapy-for-localized-prostate-cancer
#3
Kentaro Ishii, Toshiko Yamanaga, Ryo Ogino, Yukinari Hosokawa, Shun Kishimoto, Ryuta Nakahara, Chiaki Shimada, Ryu Kawamorita, Takuhito Tada, Yoshiki Hayashi, Toshifumi Nakajima
PURPOSE: This study aimed to compare bowel and urinary health-related quality of life (HRQOL) between prostate-only (PO) volumetric modulated arc therapy (VMAT) and whole-pelvis (WP) VMAT in patients with localized prostate cancer. METHODS AND MATERIALS: A total of 234 patients treated with definitive VMAT to 78 Gy in 39 fractions were enrolled. Of these, 108 patients received PO-VMAT and 126 patients received initial WP-VMAT to 46.8 Gy in 26 fractions using a simultaneous integrated boost technique...
November 5, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29307474/predictors-of-clinical-outcome-of-colonic-stents-in-patients-with-malignant-large-bowel-obstruction-due-to-extracolonic-malignancy
#4
Shahdabul Faraz, Suhail B Salem, Mark Schattner, Robin Mendelsohn, Arnold Markowitz, Emmy Ludwig, Junting Zheng, Hans Gerdes, Pari Shah
BACKGROUND AND AIMS: Colonic stent placement in patients with large-bowel obstruction (LBO) secondary to extra colonic malignancy (ECM) has been evaluated in small series with heterogeneous results. Our aim is to better characterize the technical and clinical success of colonic stent placement and to identify factors that affect this success in ECM patients. METHODS: All patients at a single high-volume center who presented for colonic stent placement for LBO due to ECM between 2001 and 2012 were retrospectively identified...
January 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29304991/a-multi-institutional-phase-2-trial-of-prostate-stereotactic-body-radiation-therapy-sbrt-using-continuous-real-time-evaluation-of-prostate-motion-with-patient-reported-quality-of-life
#5
William C Jackson, Robert T Dess, Dale W Litzenberg, Pin Li, Matthew Schipper, Seth A Rosenthal, Garrick C Chang, Eric M Horwitz, Robert A Price, Jeff M Michalski, Hiram A Gay, John T Wei, Mary Feng, Felix Y Feng, Howard M Sandler, Robert E Wallace, Daniel E Spratt, Daniel A Hamstra
PURPOSE: The use of stereotactic body radiation therapy (SBRT) for prostate cancer has been reported predominantly from single institutional studies, although concerns for broader adoption exist. METHODS AND MATERIALS: From 2011 through 2013, 66 men were accrued to a phase 2 trial at 5 centers. SBRT consisted of 5 fractions of 7.4 Gy to a total dose of 37 Gy using conventional linear accelerators. Electromagnetic transponders were used for motion management. Health-related quality of life (HRQOL) was evaluated via the Expanded Prostate Cancer Index Composite 26 questionnaire...
January 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29304105/dosimetric-evaluation-of-magnetic-resonance-generated-synthetic-ct-for-radiation-treatment-of-rectal-cancer
#6
Hesheng Wang, Kevin Du, Juliet Qu, Hersh Chandarana, Indra J Das
PURPOSE: The purpose of this study was to assess the dosimetric equivalence of magnetic resonance (MR)-generated synthetic CT (synCT) and simulation CT for treatment planning in radiotherapy of rectal cancer. METHODS: This study was conducted on eleven patients who underwent whole-body PET/MR and PET/CT examination in a prospective IRB-approved study. For each patient synCT was generated from Dixon MR using a model-based method. Standard treatment planning directives were used to create a four-field box (4F), an oblique four-field (O4F) and a volumetric modulated arc therapy (VMAT) plan on synCT for treatment of rectal cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29274599/bowel-obstruction-in-obturator-hernia-a-challenging-diagnosis
#7
L Conti, E Baldini, P Capelli, C Capelli
INTRODUCTION: The obturator hernia is a rare pelvic hernia that often comes in the shape of bowel obstruction caused by the presence of an intestinal segment, more often ileum, passing trough the obturator foramen of the pelvic wall (Fig. 1). This type of hernia accounts for 0.5-1.4% of all hernias. CASE PRESENTATION: We report the clinical case of a 84-year-old woman with no previous surgical interventions, who went to the emergency room complaining of vomit and nausea, bowels closed to gas and stool, which she had experienced for three previous days...
December 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29273378/safety-and-efficacy-of-preoperative-abdominal-aortic-balloon-occlusion-in-placenta-increta-and-or-percreta
#8
Wenjuan Sun, Shuhong Duan, Gang Xin, Juan Xiao, Fanzhen Hong, Haijie Hong, Yuange Wu, Yongping Xu
BACKGROUND: With the increase of cesarean deliveries globally, the incidence of placenta adhesive disorder has been on the rise greatly which is associated closely with maternal and infant morbidity and mortality. We sought to investigate the safety and efficacy of preoperative transfemoral balloon occlusion of abdominal aorta in cesarean section of women with placenta increta or percreta. METHODS: We conducted a retrospective study of 31 patients with placenta increta or percreta diagnosed by ultrasound and/or magnetic resonance imaging...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29261354/prospective-comparison-of-standard-versus-low-radiation-dose-ct-enterography-for-the-quantitative-assessment-of-crohn-disease
#9
Greg Rosenfeld, Jacqueline Brown, Patrick M Vos, Jonathon Leipsic, Robert Enns, Brian Bressler
OBJECTIVE: CT enterography (CTE) is sensitive and specific for active inflammatory changes of Crohn disease (CD), but its use has been limited by exposure to ionizing radiation. The objective of this study is to show the noninferiority of a model-based iterative reconstruction (MBIR) technique using lower radiation doses compared with standard-dose CTE in the assessment of CD. SUBJECTS AND METHODS: Patients referred to a hospital radiology department for CTE for the evaluation of CD underwent both a standard examination (used to generate filtered back-projection and adaptive statistical iterative reconstruction [ASIR] images) and low-dose MBIR CTE performed in a random sequence on the same day...
December 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29245220/case-report-of-intestinal-non-rotation-heterotaxy-and-polysplenia-in-a-patient-with-pancreatic-cancer
#10
Spyridon Pagkratis, Sara Kryeziu, Miranda Lin, Samah Hoque, Juan Carlos Bucobo, Jonathan M Buscaglia, Georgios V Georgakis, Aaron R Sasson, Joseph Kim
RATIONALE: Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly complex. This case report demonstrates successful pancreatic cancer resection despite the patient's complicated anatomy. PATIENT CONCERNS: An 82-year-old female presented to our institution with complaints of mild right upper quadrant pain radiating to the mid-epigastric region...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29233486/cetuximab-combined-with-induction-oxaliplatin-and-capecitabine-followed-by-neoadjuvant-chemoradiation-for-locally-advanced-rectal-cancer-swog-0713
#11
Cynthia Gail Leichman, Shannon L McDonough, Stephen R Smalley, Kevin G Billingsley, Heinz-Josef Lenz, Matthew A Beldner, Aram F Hezel, Mario R Velasco, Katherine A Guthrie, Charles D Blanke, Howard S Hochster
BACKGROUND: Neoadjuvant chemoradiation (NCRT) is standard treatment for locally advanced rectal cancer. Pathologic complete response (pCR) has associated with improved survival. In modern phase III trials of NCRT, pCR ranges from 10% to 20%. Cetuximab improves response in KRAS (KRAS proto-oncogene) wild type (wt) metastatic colorectal cancer. S0713 was designed to assess improvement in pCR with additional use of cetuximab with induction chemotherapy and NCRT for locally advanced, KRAS-wt rectal cancer...
October 24, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29230082/recent-advances-in-adam17-research-a-promising-target-for-cancer-and-inflammation
#12
REVIEW
Marcia L Moss, Dmitry Minond
Since its discovery, ADAM17, also known as TNFα converting enzyme or TACE, is now known to process over 80 different substrates. Many of these substrates are mediators of cancer and inflammation. The field of ADAM metalloproteinases is at a crossroad with many of the new potential therapeutic agents for ADAM17 advancing into the clinic. Researchers have now developed potential drugs for ADAM17 that are selective and do not have the side effects which were seen in earlier chemical entities that targeted this enzyme...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29228751/comparisons-of-health-related-quality-of-life-among-surgery-and-radiotherapy-for-localized-prostate-cancer-a-systematic-review-and-meta-analysis
#13
Cheng Chen, Zhen Chen, Kun Wang, Linkun Hu, Renfang Xu, Xiaozhou He
The objective of this study is to compare health-related quality of life (QOL) outcomes between radical prostatectomy (RP) and external beam radiation therapy (EBRT) for localized prostate cancer. PubMed, EMBASE, the Cochrane Library and Web of Science (to July 2017) were searched. Pooled analysis of each domain-specific score was calculated in relevant studies, and its change with follow-up time was explored by sub-group analysis. A total of six studies containing 4423 patients were included. Men underwent RP was associated with worse urinary and sexual domain score than EBRT (standardized mean difference (SMD) = -0...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226038/pencil-beam-scanning-proton-therapy-for-rhabdomyosarcoma-of-the-biliary-tract
#14
Luke Pater, Brian Turpin, Anthony Mascia
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with 250-350 cases diagnosed annually in the United States. Biliary tract rhabdomyosarcoma is rare, representing <1% of the RMS cases. Due to its location, resection is clinically challenging, and functional complications exist and persist from biliary obstruction. The anatomical location of this tumor presents both opportunities and challenges for pencil beam scanning proton therapy. Proton therapy offers a dosimetric and clinical advantage by sparing the healthy liver, stomach, contra-lateral kidney and bowel...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29225197/percutaneous-transgastrostomic-interventional-radiology-operated-endoscopy-facilitates-foreign-body-removal-using-rigid-endobronchial-forceps
#15
Mamdouh Khayat, Jawad S Hussain, Jeffrey Forris Beecham Chick, Anthony N Hage, Ravi N Srinivasa
Retained foreign bodies within the stomach and proximal small bowel may be problematic in patients with prior cerebrovascular injury or head, neck and esophageal malignancy, given the increased vulnerability of this patient population to complications from aspiration and increased difficulty of esophagogastroduodenoscopy in cases of tumoral obstruction. This article presents an alternative method for foreign body retrieval through an existing gastrostomy tract, which offers the benefits of fast procedure times, reduction in radiation dose and fluoroscopy time, and allows for safer retrieval of foreign bodies by using direct visualization...
December 8, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29223302/modeling-the-target-dose-fall-off-in-imrt-and-vmat-planning-techniques-for-cervical-sbrt
#16
A Brito Delgado, D Cohen, T Y Eng, D N Stanley, Z Shi, M Charlton, A N Gutiérrez
There has been growing interest in the use of stereotactic body radiotherapy (SBRT) technique for the treatment of cervical cancer. The purpose of this study was to characterize dose distributions as well as model the target dose fall-off for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques using 6 and 10 MV photon beam energies. Fifteen (n = 15) patients with non-bulky cervical tumors were planned in Pinnacle3 with a Varian Novalis Tx (HD120 MLC) using 6 and 10 MV photons with the following techniques: (1) IMRT with 10 non-coplanar beams (2) dual, coplanar 358° VMAT arcs (4° spacing), and (3) triple, non-coplanar VMAT arcs...
December 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29220303/locally-aggressive-connective-tissue-tumors
#17
Mrinal M Gounder, David M Thomas, William D Tap
In this review, we highlight the complexities of the natural history, biology, and clinical management of three intermediate connective tissue tumors: desmoid tumor (DT) or aggressive fibromatosis, tenosynovial giant cell tumor (TGCT) or diffuse-type pigmented villonodular synovitis (dtPVNS), and giant cell tumor of bone (GCTB). Intermediate histologies include tumors of both soft tissue and bone origin and are locally aggressive and rarely metastatic. Some common aspects to these tumors are that they can be locally infiltrative and/or impinge on critical organs, which leads to disfigurement, pain, loss of function and mobility, neurovascular compromise, and occasionally life-threatening consequences, such as mesenteric, bowel, ureteral, and/or bladder obstruction...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29204529/late-small-bowel-toxicity-after-aggressive-abdominopelvic-intensity-modulated-radiation-therapy
#18
Andrew Ling, Eli Furhang, Shannon N Ryemon, Ronald D Ennis
Purpose: We retrospectively analyzed late small bowel toxicity in patients who received abdominal or pelvic intensity modulated radiation therapy (IMRT) to the small bowel with a maximum dose greater than the generally accepted maximal tolerable dose of 45 Gy. Methods and materials: All patients (N = 94) who received IMRT with a point dose of at least 45 Gy to tightly contoured small bowel between 2005 and 2014 at our institution were included. The median prescribed treatment dose was 70...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204160/does-supplemental-external-beam-radiation-therapy-impact-urinary-bowel-and-erectile-function-following-permanent-prostate-brachytherapy-results-of-two-prospective-randomized-trials
#19
Gregory S Merrick, Ava Tennant, Kent E Wallner, Robert Galbreath, Wayne M Butler, Ryan Fiano, Edward Adamovich
Purpose: To evaluate the impact of supplemental external beam radiation therapy (EBRT) prior to permanent prostate brachytherapy on long term urinary, bowel, and erectile function. Material and methods: Patient administered urinary, bowel, and erectile quality of life (QoL) instrument were obtained prior to treatment and following brachytherapy. The study population was comprised of the 457 patients who were alive as of June 2016, had been randomized to two markedly different supplemental EBRT dose regimens and a third arm without supplemental EBRT, and had completed the June 2016 QoL survey...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29203973/long-term-functional-and-oncological-outcomes-following-intersphincteric-resection-for-low-rectal-cancers
#20
Sivakumar Mahalingam, Ramakrishnan Ayloor Seshadri, Surendran Veeraiah
Surgery for low rectal cancer often involves a permanent stoma. Intersphincteric resection (ISR) with colo-anal anastomosis is a valuable sphincter sparing surgical procedure that avoids the need for permanent stoma in patients with low rectal cancer. The aim of this study was to analyze the long-term functional and oncological outcomes following ISR. This was a retrospective analysis of patients with low rectal cancer who underwent ISR with colo-anal anastomosis in our institution between 2007 and 2015. All patients had a diversion stoma...
December 2017: Indian Journal of Surgical Oncology
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