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https://www.readbyqxmd.com/read/29777788/modified-transanosphincteric-york-mason-repair-of-non-radiated-rectourinary-fistulae-patient-reported-fecal-continence-outcomes
#1
Maxim J McKibben, Joceline S Fuchs, Alexander T Rozanski, Jeremy M Scott, Craig Olson, Farshid Araghizadeh, Allen F Morey
OBJECTIVES: To review our experience with the modified York Mason (MYM) procedure in treatment of rectourinary fistulae (RUF), and to assess fecal continence using patient reported measures. METHODS: Retrospective review was performed for patients who underwent MYM repair of non-radiated RUF with gluteal free fat graft from 2008 to 2016 at a single institution. Success was defined as resolution of fistula without need for further surgery. The Cleveland Clinic-Florida Wexner Fecal Incontinence Score (CCFFIS) and Patient Global Impression of Improvement (PGI-I) surveys were administered by phone...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29776418/the-impact-of-contour-variation-on-tumour-control-probability-in-anal-cancer
#2
Michael P Jones, Jarad Martin, Kerwyn Foo, Patrick Estoesta, Lois Holloway, Michael Jameson
BACKGROUND: While intensity modulated radiotherapy (IMRT) has been widely adopted for the treatment of anal cancer (AC), the added contour complexity poses potential risks. This study investigates the impact of contour variation on tumour control probability (TCP) when using IMRT for AC. METHODS: Nine Australian centres contoured a single computed tomography dataset of a patient with AC. The same optimised template-based IMRT planning protocol was applied to each contour set to generate nine representative treatment plans and their corresponding dose volume histograms...
May 18, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29772077/a-feature-alignment-score-for-online-cone-beam-ct-based-image-guided-radiotherapy-for-prostate-cancer
#3
Catriona Hargrave, Timothy Deegan, Michael Poulsen, Tomasz Bednarz, Fiona Harden, Kerrie Mengersen
PURPOSE: To develop a method for scoring online cone-beam CT (CBCT)-to-planning CT image feature alignment to inform prostate image-guided radiotherapy (IGRT) decision-making. The feasibility of incorporating volume variation metric thresholds, predictive of delivering planned dose into weighted functions, was investigated. METHODS: Radiation therapists and radiation oncologists participated in workshops where they reviewed prostate CBCT-IGRT case examples and completed a paper-based survey of image feature matching practices...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29769060/biopro-rcmi-1505-trial-multicenter-study-evaluating-the-use-of-a-biodegradable-balloon-for-the-treatment-of-intermediate-risk-prostate-cancer-by-intensity-modulated-radiotherapy-study-protocol
#4
David Pasquier, Emilie Bogart, François Bonodeau, Thomas Lacornerie, Eric Lartigau, Igor Latorzeff
BACKGROUND: Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases risks of urinary and bowel toxicity. Recently the contribution of "spacers" positioned in the septum between the rectum and the prostate could improve the functional results of intensity modulated radiation therapy (IMRT). To date most of the evaluated devices were polyethylen glycol (PEG) and hyaluronic acid (HA)...
May 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29755913/concurrent-chemoradiation-affects-the-clinical-outcome-of-small-bowel-complications-following-pelvic-irradiation-prospective-observational-study-from-a-regional-cancer-center
#5
Velagala Jayapala Reddy, Sathasivam Sureshkumar, Chellappa Vijayakumar, Anandhi Amaranathan, Sundaramurthi Sudharsanan, Prem Shyama, Chinnakali Palanivel
Background To appraise the spectrum of small bowel complications following pelvic irradiation and to assess the clinical outcome and factors associated with adverse clinical outcome in these patients. Methods This descriptive clinical study was done for three years in a tertiary care center in South India. Patients managed for post-irradiation small bowel complications, irrespective of the indication for radiotherapy, were studied. Patients with associated non-gastrointestinal radiation toxicity, radiation proctitis, and radiation colitis were excluded...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29750135/pitfalls-of-ovarian-ablative-magnetic-resonance-guided-radiation-therapy-for-refractory-endometriosis
#6
Shyama Tetar, Anna Bruynzeel, Omar Bohoudi, Theodoor Nieboer, Frank Lagerwaard
In this case presentation, we describe the challenges of performing magnetic resonance-guided radiation therapy (MRgRT) with plan adaptation in a patient with advanced endometriosis, in whom several prior therapeutic attempts were unsuccessful and extensive pelvic irradiation was regarded as being too toxic. Treatment was delivered in two sessions, first for the seemingly only active right ovary, and at a later stage for the left ovary. Some logistical problems were encountered during the preparation of the first treatment, which were subsequently optimized for the second treatment by using transvaginal ultrasound to determine the optimum time point for simulation and delivery...
March 9, 2018: Curēus
https://www.readbyqxmd.com/read/29749270/the-effect-of-time-interval-between-radiotherapy-and-hyperthermia-on-planned-equivalent-radiation-dose
#7
C M van Leeuwen, J Crezee, A L Oei, N A P Franken, L J A Stalpers, A Bel, H P Kok
PURPOSE: Thermoradiotherapy is an effective treatment for locally advanced cervical cancer. However, the optimal time interval between radiotherapy and hyperthermia, resulting in the highest therapeutic gain, remains unclear. This study aims to evaluate the effect of time interval on the therapeutic gain using biological treatment planning. METHODS: Radiotherapy and hyperthermia treatment plans were created for 15 cervical cancer patients. Biological modeling was used to calculate the equivalent radiation dose, that is, the radiation dose that results in the same biological effect as the thermoradiotherapy treatment, for different time intervals ranging from 0-4 h...
May 11, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29741203/peptide-receptor-radionuclide-therapy-for-advanced-gastroenteropancreatic-neuroendocrine-tumors-from-oncology-perspective
#8
Agnieszka Kolasińska-Ćwikła, Anna Łowczak, Katarzyna Maciejkiewicz Maciejkiewicz, Jarosław Bogdan Ćwikła
Peptide Receptor Radionuclide Therapy (PRRT) is a form of molecular targeted therapy which is performed by using a small peptide (somatostatin analogue - SSA) that is coupled with a radionuclide beta emitting radiation. PRRT is a nuclear medicine for the systemic treatment of non-resectable, metastasized well/moderately differentiated, neuroendocrine tumours (NET) with overexpression of somatostatin receptor. These types of tumours include gastroenteropancreatic neoplasm (GEP-NENs), e.g. arising from the small bowel (often called carcinoid tumours), the pancreas, duodenum or stomach, but also from the large bowel or the lung and many other tissues (so called diffuse neuroendocrine system)...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29736358/brachy-ing-unresectable-endometrial-cancers-with-magnetic-resonance-guidance
#9
Jessica L Conway, Jelena Lukovic, Stephane Laframboise, Sarah E Ferguson, Kathy Han
The standard treatment for endometrial cancer is upfront surgery. However, surgical resection is challenging in locally advanced cases extending to the vagina, bladder, bowel, rectum, or parametria. Historically, these cases were managed palliatively due to the inability to escalate radiation dose safely and accurately, and there is a paucity of literature supporting definitive radiation for these patients. Technological advances in brachytherapy, including magnetic resonance guidance (MR-guidance) and interstitial techniques, have improved target precision and dose escalation without additional toxicity to permit curative management...
March 5, 2018: Curēus
https://www.readbyqxmd.com/read/29722660/the-efficacy-and-safety-of-conventional-and-hypofractionated-high-dose-radiation-therapy-for-prostate-cancer-in-an-elderly-population-a-subgroup-analysis-of-the-chhip-trial
#10
James M Wilson, David P Dearnaley, Isabel Syndikus, Vincent Khoo, Alison Birtle, David Bloomfield, Ananya Choudhury, John Graham, Catherine Ferguson, Zafar Malik, Julian Money-Kyrle, Joe M O'Sullivan, Miguel Panades, Chris Parker, Yvonne Rimmer, Christopher Scrase, John Staffurth, Andrew Stockdale, Clare Cruickshank, Clare Griffin, Emma Hall
PURPOSE: Outcome data on radiation therapy for prostate cancer in an elderly population are sparse. The CHHiP (Conventional or Hypofractionated High Dose Intensity Modulated Radiotherapy in Prostate Cancer) trial provides a large, prospectively collected, contemporary dataset in which to explore outcomes by age. METHODS AND MATERIALS: CHHiP participants received 3 to 6 months of androgen deprivation therapy and were randomly assigned (1:1:1) to receive 74 Gy in 37 fractions (conventional fractionation), 60 Gy in 20 fractions, or 57 Gy in 19 fractions...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29705029/usefulness-of-contrast-enhanced-ultrasound-ceus-in-inflammatory-bowel-disease-ibd
#11
REVIEW
Silvia Pecere, Grainne Holleran, Maria Elena Ainora, Matteo Garkovic, Franco Scaldaferri, Antonio Gasbarrini, Maria Assunta Zocco
Intestinal ultrasonography has emerged as a cheap, non-invasive and readily accessible modality for the assessment of a number of gastroenterological diseases. Over the last decade, particularly due to the widespread use of biological agents in Inflammatory Bowel Disease (IBD), guidelines regarding management and follow-up advise more regular disease assessment and surveillance in order to guide treatment adjustments, and provide more personalised care. Given the young age of the majority of patients with IBD the availability of an alternative modality to harmful radiation or the risks of endoscopy for this indication offers an appealing advantage...
April 3, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29704011/-ceus-diagnosis-of-benign-liver-lesions
#12
REVIEW
K Müller-Peltzer, J Rübenthaler, G Negrao de Figueiredo, D A Clevert
CLINICAL/METHODICAL ISSUE: Focal liver lesions are commonly seen during routine ultrasound examinations. STANDARD RADIOLOGICAL METHODS: With native ultrasound there are lesions that cannot be sufficiently characterized. In these cases additional imaging might be necessary. METHODICAL INNOVATIONS: With contrast-enhanced ultrasound (CEUS), focal liver lesions can be characterized with high diagnostic accuracy. After the ultrasound contrast agent has been injected into a peripheral vein, the examiner saves video loops of the arterial, portal venous and late contrast phases...
April 27, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29703875/mesenteric-bones-intra-abdominal-heterotopic-ossification
#13
A Michael, S Narasimman, N Jasjit Singh
Intra-abdominal heterotopic ossification usually develops after abdominal surgery and can cause complications such as bowel obstruction and even intestinal perforation. Bisphosphonates, NSAIDs and even local radiation is used as prophylaxis or treatment. Surgeons must consider heterotopic ossification and its complications as a differential when managing complex polytrauma patients with suspicious radiographic densities.
April 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29685526/paediatric-magnetic-resonance-enterography-in-inflammatory-bowel-disease
#14
Mary-Louise C Greer
Paediatric magnetic resonance enterography (MRE) has been increasingly employed in the evaluation of inflammatory bowel disease (IBD) in the past decade. This is in parallel with a global rise in paediatric-onset IBD, greater recognition of the hazards of ionizing radiation, especially in children, and improved treatment options. MRE is now the reference standard for assessing the small bowel in suspected or proven paediatric IBD, and is central to the diagnosis of Crohn's disease (CD), helping distinguish it from ulcerative colitis...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29682620/a-prospective-cohort-study-of-patient-reported-vomiting-retching-nausea-and-antiemetic-use-during-neoadjuvant-long-course-radiation-therapy-and-concurrent-5-fluorouracil-based-chemotherapy-for-rectal-adenocarcinoma
#15
Kristopher Dennis, Liang Zeng, Carlo De Angelis, Hans Chung, Natalie Coburn, Edward Chow, C Shun Wong
Background and purpose: Antiemetic guidelines suggest daily prophylaxis with a serotonin3 receptor antagonist (5-HT3 RA) as an option for patients receiving long-course neoadjuvant radiation therapy and concurrent 5-fluorouracil-based chemotherapy for rectal cancer, despite the risks that 5-HT3 RA-induced constipation may pose. We explored the incidence of patient-reported vomiting, retching, nausea and antiemetic intake among patients in this setting to determine if these risks are justified...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29664839/a-population-based-assessment-of-urologic-procedures-and-operations-after-surgery-or-pelvic-radiation-for-cervical-cancer
#16
Blayne Welk, Christopher Wallis, David DʼSouza, Jacob McGee, Robert K Nam
OBJECTIVE: The treatment of cervical cancer can result in genitourinary morbidity. We measured selected urologic procedures after the treatment of cervical cancer with either surgery or radiation. METHODS: We used administrative data from the province of Ontario Canada to identify adult women who had nonmetastatic cervical cancer and were treated with surgery or radiation between 1994 and 2014. Study outcomes were surgical or procedure codes representing ureteric repair or fistula repair...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29657142/age-and-sex-dependent-frequency-of-fat-metaplasia-and-other-structural-changes-of-the-sacroiliac-joints-in-patients-without-axial-spondyloarthritis-a-retrospective-cross-sectional-mri-study
#17
Katharina Ziegeler, Hamama Eshkal, Claudia Schorr, Joachim Sieper, Torsten Diekhoff, Marcus R Makowski, Bernd Hamm, Kay-Geert A Hermann
OBJECTIVE: To determine the prevalence of fat metaplasia and other structural lesions of the sacroiliac joints associated with axial spondyloarthritis in a nonrheumatological patient population. METHODS: Magnetic resonance imaging examinations that included the pelvis and were performed in patients without known rheumatological disease were used for this retrospective cross-sectional study. These images were evaluated for sacroiliac fat metaplasia, sclerosis, osteophytes, and joint space alterations such as erosions or ankylosis...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29650363/chemotherapy-versus-chemoradiotherapy-after-surgery-and-preoperative-chemotherapy-for-resectable-gastric-cancer-critics-an-international-open-label-randomised-phase-3-trial
#18
Annemieke Cats, Edwin P M Jansen, Nicole C T van Grieken, Karolina Sikorska, Pehr Lind, Marianne Nordsmark, Elma Meershoek-Klein Kranenbarg, Henk Boot, Anouk K Trip, H A Maurits Swellengrebel, Hanneke W M van Laarhoven, Hein Putter, Johanna W van Sandick, Mark I van Berge Henegouwen, Henk H Hartgrink, Harm van Tinteren, Cornelis J H van de Velde, Marcel Verheij
BACKGROUND: Both perioperative chemotherapy and postoperative chemoradiotherapy improve survival in patients with resectable gastric cancer from Europe and North America. To our knowledge, these treatment strategies have not been investigated in a head to head comparison. We aimed to compare perioperative chemotherapy with preoperative chemotherapy and postoperative chemoradiotherapy in patients with resectable gastric adenocarcinoma. METHODS: In this investigator-initiated, open-label, randomised phase 3 trial, we enrolled patients aged 18 years or older who had stage IB- IVA resectable gastric or gastro-oesophageal adenocarcinoma (as defined by the American Joint Committee on Cancer, sixth edition), with a WHO performance status of 0 or 1, and adequate cardiac, bone marrow, liver, and kidney function...
May 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29607792/nutritional-strategies-to-prevent-gastrointestinal-toxicity-during-pelvic-radiotherapy
#19
Linda J Wedlake
Radiotherapy-induced damage to non-cancerous gastrointestinal mucosa has effects on secretory and absorptive functions and can interfere with normal gastrointestinal physiology. Nutrient absorption and digestion may be compromised. Dietary manipulation is an attractive option with sound rationale for intervention. The aim of this review was to synthesise published evidence for the use of elemental formulae, low or modified fat diets, fibre, lactose restriction and probiotics, prebiotics and synbiotics to protect the bowel from gastrointestinal side effects during long-course, radical pelvic radiotherapy...
April 2, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29596461/ct-utilization-abruptly-increases-at-age-18-among-patients-with-inflammatory-bowel-diseases-in-the-hospital
#20
Shail M Govani, Peter D R Higgins, Joel H Rubenstein, Ryan W Stidham, Akbar K Waljee
OBJECTIVES: Patients with inflammatory bowel disease(IBD) are frequently exposed to computed tomography (CT). Each CT exposes patients to radiation that cumulatively could increase the risk of malignancy, particularly in younger patients. We aim to study the effect of age on CT use in IBD patients seen in the Emergency Department (ED) or the hospital. METHODS: We conducted a retrospective cohort study of IBD patients identified in Truven Health Marketscan databases between 2009-2013...
2018: PloS One
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