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https://www.readbyqxmd.com/read/28105159/small-bowel-metastasis-from-pancreatic-cancer-in-a-long-term-survival-patient-with-synchronous-advanced-malignant-pleural-mesothelioma-a-case-report-and-literature-review
#1
Morena Fasano, Carminia Maria Della Corte, Giovanni Vicidomini, Valerio Scotti, Pier Francesco Rambaldi, Alfonso Fiorelli, Marina Accardo, Ferdinando De Vita, Mario Santini, Fortunato Ciardiello, Floriana Morgillo
Diffuse malignant pleural mesothelioma (MPM) is an aggressive tumor that originates from the surface of the pleura. Approximately 70% of cases are associated with chronic asbestos exposure. MPM is regarded as an incurable disease, with a median survival of ~2 years following intensive multimodality treatment. Pancreatic cancer is a malignancy also associated with a poor prognosis, with only 2% of patients surviving for 5 years. The majority of patients with pancreatic cancer are diagnosed with an advanced stage of disease and experience a poor response to therapy...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28091700/computed-tomography-localization-of-the-appendix-in-the-pediatric-population-relative-to-the-lumbar-spine
#2
John Davis, Albert T Roh, Matthew B Petterson, Tammy R Kopelman, Samantha L Matz, Daniel G Gridley, Mary J Connell
BACKGROUND: Computed tomography (CT) is commonly used to evaluate suspected acute appendicitis. Although very effective, CT uses ionizing radiation, exposing patients to an increased risk of cancer. OBJECTIVE: This study assessed the potential for decreasing the field of view of the CT (and therefore the dose to the patient) in the evaluation of suspected acute appendicitis in children. MATERIALS AND METHODS: This study was a retrospective review of prospectively collected data from 212 consecutive patients who underwent CT for suspected acute appendicitis...
January 14, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28086825/toxicity-and-quality-of-life-report-of-a-phase-ii-study-of-stereotactic-body-radiotherapy-sbrt-for-low-and-intermediate-risk-prostate-cancer
#3
Matthew J Boyer, Michael A Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu, W Robert Lee
BACKGROUND: Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radiotherapy with real-time motion management and daily plan re-optimization for low to intermediate risk prostate cancer was undertaken to evaluate this hypothesis. This report details the toxicity and quality of life following treatment. METHODS: From 2009 to 2013, 60 patients with T1-T2c prostate cancer with a Gleason score of 6 and PSA ≤ 15 or Gleason score of 7 and PSA ≤ 10 were enrolled...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28057090/-ct-guidance-125-i-seed-implantation-for-pelvic-recurrent-rectal-cancer-assisted-by-3d-printing-individual-non-coplanar-template
#4
H Wang, J J Wang, Y L Jiang, S Q Tian, Z Ji, F X Guo, H T Sun, J H Fan, Y P Xu
Objective: To analyze the difference of dosimetric parameters between pre-plan and post-plan of (125)I radioactive seed implantation assisted by 3D printing individual non-coplanar template (3D printing template) for locally recurrent rectal cancer (LRRC). Methods: From February 2016 to April 2016, a total of 10 patients with locally recurrent rectal cancer received (125)I seeds implantation under CT guidance assisted by 3D printing template in Department of Radiation Oncology, Peking University Third Hospital...
December 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28049025/correction-of-vitamin-d-deficiency-using-sublingually-administered-vitamin-d2-in-a-crohn-s-disease-patient-with-mal-absorption-and-a-new-ileostomy
#5
REVIEW
Patrick McCullough, Robert Heaney
Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2...
December 31, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28048910/su-g-jep2-10-on-the-need-for-a-dynamic-model-for-patient-specific-distortion-corrections-for-mr-only-pelvis-treatment-planning
#6
C Glide-Hurst, W Zheng, C Stehning, S Weiss, S Renisch
PURPOSE: Patient-specific distortions, particularly near tissue/air interfaces, require assessment and possible corrections for MRI-only radiation treatment planning (RTP). However, patients are dynamic due to changes in physiological status and motion during imaging sessions. This work investigated the need for dynamic patient-specific distortion corrections to support pelvis MR-only RTP. METHODS: The pelvises of healthy volunteers were imaged at 1.0T, 1.5T, and 3...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048479/we-ab-207b-01-dose-tolerance-for-sbrt-sabr
#7
J Grimm
PURPOSE: Stereotactic body radiation therapy (SBRT) / stereotactic ablative body radiotherapy (SABR) is gaining popularity, but quantitative dose tolerance has still been lacking. To improve this, the April 2016 issue of Seminars in Radiation Oncology will have normal tissue complication probability (NTCP) models for 10 critical structures: optic pathway, cochlea, oral mucosa, esophagus, chestwall, aorta, bronchi, duodenum, small bowel, and spinal cord. METHODS: The project included more than 1500 treatments in 1-5 fractions using CyberKnife, Gamma Knife, or LINAC, with 60 authors from 15 institutions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047827/su-c-204-01-a-dosimetric-investigation-into-the-effects-of-yttrium-90-radioembolization-on-the-gi-tract-in-vivo-and-histological-analysis-in-an-animal-model
#8
A Pasciak, L Nodit, A Bourgeois, B Paxton, A Arepally, Y Bradley
PURPOSE: In Yttrium-90 (90Y) radioembolization, non-target embolization (NTE) to the stomach or small bowel can result in ulceration, a rare but difficult to manage clinical complication. However, dosimetric thresholds for toxicity to these tissues from radioembolization have never been evaluated in a controlled setting. We performed an analysis of the effect of 90Y radioembolization in a porcine model at different absorbed-dose endpoints. METHODS: Under approval of the University of Tennessee IACUC, 6 female pigs were included in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047756/we-ab-207b-09-margin-reduction-for-planning-target-volume-ptv-in-patients-with-localized-prostate-cancer-impact-on-delivered-dose-and-quality-of-life
#9
A Kumarasiri, C Liu, S Brown, C Glide-Hurst, M Elshaikh, I Chetty, B Movsas
PURPOSE: To estimate the delivered (cumulative) dose to targets and organs at risk for localized prostate cancer patients treated with reduced PTV margins and to evaluate preliminary patient reported quality-of-life (QOL). METHODS: Under an IRB-approved protocol, 20 prostate cancer patients (including 11 control patients) were treated with reduced planning margins (5 mm uniform with 4 mm at prostate/rectum interface). Control patients had standard margin (10/6 mm)-based treatments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047083/su-c-bra-01-interactive-auto-segmentation-for-bowel-in-online-adaptive-mri-guided-radiation-therapy-by-using-a-multi-region-labeling-algorithm
#10
Y Lu, I Chen, R Kashani, H Wan, N Maughan, D Muccigrosso, P Parikh
PURPOSE: In MRI-guided online adaptive radiation therapy, re-contouring of bowel is time-consuming and can impact the overall time of patients on table. The study aims to auto-segment bowel on volumetric MR images by using an interactive multi-region labeling algorithm. METHODS: 5 Patients with locally advanced pancreatic cancer underwent fractionated radiotherapy (18-25 fractions each, total 118 fractions) on an MRI-guided radiation therapy system with a 0.35 Tesla magnet and three Co-60 sources...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046785/su-f-j-173-online-replanning-for-dose-painting-based-on-changing-adc-map-of-pancreas-cancer
#11
O Ates, E Ahunbay, B Erickson, X Li
PURPOSE: The introduction of MR-guided radiation therapy (RT), e.g., MR-Linac, would allow dose painting to adapt spatial RT response revealed from MRI data during the RT delivery. The purpose of this study is to investigate the use of an online replanning method to adapt dose painting from the MRI Apparent Diffusion Coefficient (ADC) map acquired during the delivery of RT for pancreatic cancers. METHODS: Original dose painting plans were created based on multi-parametric simulation MRI including T1, T2 and ADC, using a treatment planning system (MONACO, Elekta) equipped with an online replanning algorithm (WSO, warm start optimization)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046532/su-f-t-433-evaluation-of-a-new-dose-mimicking-application-for-clinical-flexibility-and-reliability
#12
D Hoffman, C Kumaran Nair, C Wright, T Yamamoto, J Mayadev, R Valicenti, S Benedict, J Markham, Y Rong
PURPOSE: Clinical workflow and machine down time occasionally require patients to be temporarily treated on a system other than the initial treatment machine. A new commercial dose mimicking application provides automated cross-platform treatment planning to expedite this clinical flexibility. The aim of this work is to evaluate the feasibility of automatic plan creation and establish a robust clinical workflow for prostate and pelvis patients. METHODS: Five prostate and five pelvis patients treated with helical plans were selected for re-planning with the dose mimicking application, covering both simple and complex scenarios...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046466/su-f-t-395-evaluation-of-best-dosimetry-achievable-with-vmat-and-imrt-treatment-techniques-targeting-borderline-resectable-pancreatic-cancer
#13
K Harpool, E Schnell, T Herman, S Ahmad, T De La Fuente Herman
PURPOSE: To determine from retrospective study the most appropriate technique for targeting small borderline operable pancreatic cancer surrounding blood vessels by evaluating the dosimetry and normal tissue sparing achievable using Volumetric Modulated Arc Therapy (VMAT) and Intensity Modulated Radiation Therapy (IMRT). METHODS: Treatment plans from ten patients who have undergone treatment with a prescribed dose of 4950 cGy, at 275 cGy per fraction, were analyzed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046457/su-f-t-355-evaluation-of-knowledge-based-planning-model-for-the-cervical-cancer-radiotherapy
#14
X Chen, J Wang, W Hu
PURPOSE: The Varian RapidPlan™ is a commercial knowledge-based optimization process which uses a set of clinically used treatment plans to train a model that can predict individualized dose-volume objectives. The purpose of this study is to evaluate the performance of RapidPlan to generate intensity modulated radiation therapy (IMRT) plans for cervical cancer. METHODS: Totally 70 IMRT plans for cervical cancer with varying clinical and physiological indications were enrolled in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046395/su-f-t-590-modeling-ptv-dose-fall-off-for-cervical-cancer-sbrt-treatment-planning-using-vmat-and-step-and-shoot-imrt
#15
A Brito Delgado, D Cohen, T Eng, A Gutierrez
PURPOSE: Due to the high dose per fraction in SBRT, dose conformity and dose fall-off are critical. In patients with cervical cancer, rapid dose fall-off is particularly important to limit dose to the nearby rectum, small bowel, and bladder. This study compares the target volume dose fall-off for two radiation delivery techniques, fixed-field IMRT & VMAT, using non-coplanar beam geometries. Further comparisons are made between 6 and 10MV photon beam energies. METHODS: Eleven (n=11) patients were planned in Pinnacle3 v9...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046275/su-f-p-29-impact-of-oral-contrast-agent-for-assisting-in-outlining-small-intestine-on-pelvic-imat-dose-in-patients-with-cervical-cancer
#16
R Zhang, W Bai, X Fan
PURPOSE: As the advanced intensity modulated arc therapy(IMAT) delivery systems becoming a main role of treatment ways, which places even greater demands on delivering accuracy. The impact of oral contrast agent (meglumine diatrizoate) for assisting in outlining the small intestine on pelvic IMAT dose in patients with cervical cancer was investigated. METHODS: Ten cervical cancer patients for postoperative radiotherapy underwent CT scans, and the planning target volumes (PTV) and organs at risk (including the small intestine, rectum, bladder, colon and the left and right femoral head) were contoured...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28018097/contraindications-for-video-capsule-endoscopy
#17
REVIEW
Dirk Bandorski, Niehls Kurniawan, Peter Baltes, Reinhard Hoeltgen, Matthias Hecker, Dominik Stunder, Martin Keuchel
Video capsule endoscopy (VCE) has been applied in the last 15 years in an increasing field of applications. Although many contraindications have been put into perspective, some precautions still have to be considered. Known stenosis of the gastrointestinal tract is a clear contraindication for VCE unless surgery is already scheduled or at least has been considered as an optional treatment modality. In patients with a higher incidence of stenosis, as in an established diagnosis of Crohn's disease, clinical signs of obstruction, prior radiation or surgical small bowel resection, a preceding test with the self-dissolving patency capsule can override this contraindication...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28001303/predictors-of-multidomain-decline-in-health-related-quality-of-life-after-stereotactic-body-radiation-therapy-sbrt-for-prostate-cancer
#18
Robert T Dess, William C Jackson, Simeng Suy, Payal D Soni, Jae Y Lee, Ahmed E Abugharib, Zachary S Zumsteg, Felix Y Feng, Daniel A Hamstra, Sean P Collins, Daniel E Spratt
BACKGROUND: Stereotactic body radiation therapy (SBRT) for localized prostate cancer involves high-dose-per-fraction radiation treatments. Its use is increasing, but concerns remain about treatment-related toxicity. The authors assessed the incidence and predictors of a global decline in health-related quality of life (HRQOL) after prostate SBRT. METHODS: From 2008 to 2014, 713 consecutive men with localized prostate cancer received treatment with SBRT according to a prospective institutional protocol...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27979445/highly-efficient-training-refinement-and-validation-of-a-knowledge-based-planning-quality-control-system-for-radiation-therapy-clinical-trials
#19
Nan Li, Ruben Carmona, Igor Sirak, Linda Kasaova, David Followill, Jeff Michalski, Walter Bosch, William Straube, Loren K Mell, Kevin L Moore
PURPOSE: To demonstrate an efficient method for training and validation of a knowledge-based planning (KBP) system as a radiation therapy clinical trial plan quality-control system. METHODS AND MATERIALS: We analyzed 86 patients with stage IB through IVA cervical cancer treated with intensity modulated radiation therapy at 2 institutions according to the standards of the INTERTECC (International Evaluation of Radiotherapy Technology Effectiveness in Cervical Cancer, National Clinical Trials Network identifier: 01554397) protocol...
January 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27943484/utility-of-mr-enterography-and-ultrasound-for-the-investigation-of-small-bowel-crohn-s-disease
#20
REVIEW
Gauraang Bhatnagar, Conrad Von Stempel, Steve Halligan, Stuart A Taylor
: Cross sectional Imaging plays an increasingly important role the diagnosis and management of Crohn's disease. Particular emphasis is placed on MRI and Ultrasound as they do not impart ionising radiation. Both modalities have reported high sensitivity for disease detection, activity assessment and evaluation of extra-luminal complications, and have positive effects on clinical decision making. International Guidelines now recommend MRI and Ultrasound in the routine management of Crohn's disease patients...
December 9, 2016: Journal of Magnetic Resonance Imaging: JMRI
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