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https://www.readbyqxmd.com/read/28424652/quantitative-electroencephalographic-biomarkers-in-preclinical-and-human-studies-of-huntington-s-disease-are-they-fit-for-purpose-for-treatment-development
#1
REVIEW
Michael K Leuchter, Elissa J Donzis, Carlos Cepeda, Aimee M Hunter, Ana María Estrada-Sánchez, Ian A Cook, Michael S Levine, Andrew F Leuchter
A major focus in development of novel therapies for Huntington's disease (HD) is identification of treatments that reduce the burden of mutant huntingtin (mHTT) protein in the brain. In order to identify and test the efficacy of such therapies, it is essential to have biomarkers that are sensitive to the effects of mHTT on brain function to determine whether the intervention has been effective at preventing toxicity in target brain systems before onset of clinical symptoms. Ideally, such biomarkers should have a plausible physiologic basis for detecting the effects of mHTT, be measureable both in preclinical models and human studies, be practical to measure serially in clinical trials, and be reliably measurable in HD gene expansion carriers (HDGECs), among other features...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28386574/quantitative-electroencephalograms-and-neuro-optometry-a-case-study-that-explores-changes-in-electrophysiology-while-wearing-therapeutic-eyeglasses
#2
Deborah Zelinsky, Corey Feinberg
The brain is equipped with a complex system for processing sensory information, including retinal circuitry comprising part of the central nervous system. Retinal stimulation can influence brain function via customized eyeglasses at both subcortical and cortical levels. We investigated cortical effects from wearing therapeutic eyeglasses, hypothesizing that they can create measureable changes in electroencephalogram (EEG) tracings. A Z-Bell(SM) test was performed on a participant to select optimal lenses. An EEG measurement was recorded before and after the participant wore the eyeglasses...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/28385478/quantitative-electroencephalogram-measures-in-adult-obstructive-sleep-apnea-potential-biomarkers-of-neurobehavioural-functioning
#3
REVIEW
Angela L D'Rozario, Nathan E Cross, Andrew Vakulin, Delwyn J Bartlett, Keith K H Wong, David Wang, Ronald R Grunstein
Obstructive sleep apnea (OSA) results in significantly impaired cognitive functioning and increased daytime sleepiness in some patients leading to increased risk of motor vehicle and workplace accidents and reduced productivity. Clinicians often face difficulty in identifying which patients are at risk of neurobehavioural dysfunction due to wide inter-individual variability, and disparity between symptoms and conventional metrics of disease severity such as the apnea hypopnea index. Quantitative electroencephalogram (EEG) measures are determinants of awake neurobehavioural function in healthy subjects...
October 19, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28278477/quantitative-eeg-for-predicting-upper-limb-motor-recovery-in-chronic-stroke-robot-assisted-rehabilitation
#4
Paula Trujillo, Alfonso Mastropietro, Alessandro Scano, Andrea Chiavenna, Simona Mrakic-Sposta, Marco Caimmi, Franco Molteni, Giovanna Rizzo
Stroke is a leading cause for adult disability, which in many cases causes motor deficits. Despite the developments in motor rehabilitation techniques, recovery of upper limb functions after stroke is limited and heterogeneous in terms of outcomes, and knowledge of important factors that may affect the outcome of the therapy is necessary to make a reasonable prediction for individual patients. In this study, we assessed the relationship between quantitative electroencephalographic (QEEG) measures and the motor outcome in chronic stroke patients that underwent a robot-assisted rehabilitation program to evaluate the utility of QEEG indices to predict motor recovery...
March 3, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28269639/predicting-rapid-cognitive-decline-in-alzheimer-s-disease-patients-using-quantitative-eeg-markers-and-neuropsychological-test-scores
#5
Carmina Reyes-Coronel, Markus Waser, Heinrich Garn, Manfred Deistler, Peter Dal-Bianco, Thomas Benke, Gerhard Ransmayr, Dieter Grossegger, Reinhold Schmidt
Alzheimer's Disease (AD) can take different courses: some patients remain relatively stable while others decline rapidly within a given period of time. Losing more than 3 Mini-Mental State Examination (MMSE) points in one year is classified as rapid cognitive decline (RCD). This study used neuropsychological test scores and quantitative EEG (QEEG) markers obtained at a baseline examination to identify if an AD patient will be suffering from RCD. Data from 68 AD patients of the multi-centric cohort study PRODEM-Austria were applied...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258840/increased-prognostic-accuracy-of-tbi-when-a-brain-electrical-activity-biomarker-is-added-to-loss-of-consciousness-loc
#6
Dallas Hack, J Stephen Huff, Kenneth Curley, Roseanne Naunheim, Samanwoy Ghosh Dastidar, Leslie S Prichep
BACKGROUND: Extremely high accuracy for predicting CT+ traumatic brain injury (TBI) using a quantitative EEG (QEEG) based multivariate classification algorithm was demonstrated in an independent validation trial, in Emergency Department (ED) patients, using an easy to use handheld device. This study compares the predictive power using that algorithm (which includes LOC and amnesia), to the predictive power of LOC alone or LOC plus traumatic amnesia. PARTICIPANTS: ED patients 18-85years presenting within 72h of closed head injury, with GSC 12-15, were study candidates...
February 20, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28254650/three-dimensional-components-of-selfhood-in-treatment-naive-patients-with-major-depressive-disorder-a-resting-state-qeeg-imaging-study
#7
Andrew A Fingelkurts, Alexander A Fingelkurts
Based on previous studies implicating increased functional connectivity within the self-referential brain network in major depressive disorder (MDD), and considering the functional roles of three distinct modules of such brain net (responsible for three-dimensional components of Selfhood) together with the documented abnormalities of self-related processing in MDD, we tested the hypothesis that patients with depression would exhibit increased connectivity within each module of the self-referential brain network and that the strength of these connections would correlate positively with depression severity...
February 28, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28243755/differential-diagnosis-between-patients-with-probable-alzheimer-s-disease-parkinson-s-disease-dementia-or-dementia-with-lewy-bodies-and-frontotemporal-dementia-behavioral-variant-using-quantitative-electroencephalographic-features
#8
Heinrich Garn, Carmina Coronel, Markus Waser, Georg Caravias, Gerhard Ransmayr
The objective of this work was to develop and evaluate a classifier for differentiating probable Alzheimer's disease (AD) from Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) and from frontotemporal dementia, behavioral variant (bvFTD) based on quantitative electroencephalography (QEEG). We compared 25 QEEG features in 61 dementia patients (20 patients with probable AD, 20 patients with PDD or probable DLB (DLBPD), and 21 patients with bvFTD). Support vector machine classifiers were trained to distinguish among the three groups...
February 27, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28227897/predicting-rapid-cognitive-decline-in-alzheimer-s-disease-patients-using-quantitative-eeg-markers-and-neuropsychological-test-scores
#9
Carmina Reyes-Coronel, Markus Waser, Heinrich Garn, Manfred Deistler, Peter Dal-Bianco, Thomas Benke, Gerhard Ransmayr, Dieter Grossegger, Reinhold Schmidt, Carmina Reyes-Coronel, Markus Waser, Heinrich Garn, Manfred Deistler, Peter Dal-Bianco, Thomas Benke, Gerhard Ransmayr, Dieter Grossegger, Reinhold Schmidt, Carmina Reyes-Coronel, Gerhard Ransmayr, Dieter Grossegger, Markus Waser, Peter Dal-Bianco, Thomas Benke, Manfred Deistler, Reinhold Schmidt, Heinrich Garn
Alzheimer's Disease (AD) can take different courses: some patients remain relatively stable while others decline rapidly within a given period of time. Losing more than 3 Mini-Mental State Examination (MMSE) points in one year is classified as rapid cognitive decline (RCD). This study used neuropsychological test scores and quantitative EEG (QEEG) markers obtained at a baseline examination to identify if an AD patient will be suffering from RCD. Data from 68 AD patients of the multi-centric cohort study PRODEM-Austria were applied...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28210035/effects-of-observation-of-hand-movements-reflected-in-a-mirror-on-cortical-activation-in-patients-with-stroke
#10
Moon-Young Chang, Hwan-Hee Kim, Kyeong-Mi Kim, Jae-Seop Oh, Chel Jang, Tae-Hyung Yoon
[Purpose] The purpose of this study was to examine what changes occur in brain waves when patients with stroke receive mirror therapy intervention. [Subjects and Methods] The subjects of this study were 14 patients with stroke (6 females and 8 males). The subjects were assessed by measuring the alpha and beta waves of the EEG (QEEG-32 system CANS 3000). The mirror therapy intervention was delivered over the course of four weeks (a total of 20 sessions). [Results] Relative alpha power showed statistically significant differences in the F3, F4, O1, and O2 channels in the situation comparison and higher for hand observation than for mirror observation...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28201930/electroencephalographic-correlates-of-suicidal-ideation-in-the-theta-band
#11
Sang Min Lee, Kuk-In Jang, Jeong-Ho Chae
Previous studies have indicated that the abnormalities of brain activity are associated with suicidal behavior. However, few studies have explored neurophysiologic biomarkers of suicidal ideation (SI) in healthy subjects. Here, we studied alterations of theta quantitative EEG (QEEG) in frontal regions associated with SI in young healthy subjects. Resting QEEG data were recorded from 90 young healthy subjects. The subjects were divided into two group based on Scale for Suicidal Ideation (SSI) scores: a high SSI group (n = 33) and a low SSI group (n = 57)...
February 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28199912/in-patients-suffering-from-major-depressive-disorders-quantitative-eeg-showed-favorable-changes-in-left-and-right-prefrontal-cortex
#12
Mohammad Haghighi, Sebastian Ludyga, Boshra Rahimi, Leila Jahangard, Mohammad Ahmadpanah, Saadat Torabian, Farzaneh Esnaashari, Marzieh Nazaribadie, Hafez Bajoghli, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand
BACKGROUND: Patients suffering from major depressive disorders (MDD) report anhedonia, low concentration and lack of goal-oriented behavior. Data from imaging and quantitative EEG (QEEG) studies show an asymmetry in the prefrontal cortex (PFC), with lower left as compared to right PFC-activity, associated with specific depression-related behavior. Cordance is a QEEG measurement, which combines absolute and relative power of EEG-spectra with strong correlations with regional perfusion...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28167911/quantitative-eeg-qeeg-measures-differentiate-parkinson-s-disease-pd-patients-from-healthy-controls-hc
#13
Menorca Chaturvedi, Florian Hatz, Ute Gschwandtner, Jan G Bogaarts, Antonia Meyer, Peter Fuhr, Volker Roth
Objectives: To find out which Quantitative EEG (QEEG) parameters could best distinguish patients with Parkinson's disease (PD) with and without Mild Cognitive Impairment from healthy individuals and to find an optimal method for feature selection. Background: Certain QEEG parameters have been seen to be associated with dementia in Parkinson's and Alzheimer's disease. Studies have also shown some parameters to be dependent on the stage of the disease. We wanted to investigate the differences in high-resolution QEEG measures between groups of PD patients and healthy individuals, and come up with a small subset of features that could accurately distinguish between the two groups...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28145657/comparison-of-qeeg-findings-between-adolescents-with-attention-deficit-hyperactivity-disorder-adhd-without-comorbidity-and-adhd-comorbid-with-internet-gaming-disorder
#14
Jeong Ha Park, Ji Sun Hong, Doug Hyun Han, Kyoung Joon Min, Young Sik Lee, Baik Seok Kee, Sun Mi Kim
Internet gaming disorder (IGD) is often comorbid with attention deficit hyperactivity disorder (ADHD). In this study, we compared the neurobiological differences between ADHD comorbid with IGD (ADHD+IGD group) and ADHD without comorbidity (ADHD-only group) by analyzing quantitative electroencephalogram (QEEG) findings. We recruited 16 male ADHD+IGD, 15 male ADHD-only adolescent patients, and 15 male healthy controls (HC group). Participants were assessed using Young's Internet Addiction Scale and ADHD Rating Scale...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28118690/poststroke-qeeg-informs-early-prognostication-of-cognitive-impairment
#15
Emma Schleiger, Andrew Wong, Stephen Read, Tennille Rowland, Simon Finnigan
Cognitive impairment is a common consequence of stroke, but remains difficult to predict. We investigate the ability of early QEEG assessment to inform such prediction, using binary logistic regression. Thirty-five patients (12 female, ages 18-87) suffering middle cerebral artery, ischemic stroke were studied. Resting-state EEG was recorded 48-239 h after symptom onset. Relative power for delta, theta, alpha, and beta bands, delta:alpha ratio, and peak alpha frequency were analyzed. Montreal Cognitive Assessment (MoCA) was administered, where possible, on day of EEG and at median 99 days (range 69-138) poststroke...
February 2017: Psychophysiology
https://www.readbyqxmd.com/read/28110410/neurophysiological-assessment-of-brain-dysfunction-in-critically-ill-patients-an-update
#16
REVIEW
Eric Azabou, Catherine Fischer, Jean Michel Guerit, Djillali Annane, François Mauguiere, Fréderic Lofaso, Tarek Sharshar
The aim of this review was to provide up-to-date information about the usefulness of clinical neurophysiology testing in the management of critically ill patients. Evoked potentials (EPs) and electroencephalogram (EEG) are non-invasive clinical neurophysiology tools that allow an objective assessment of the central nervous system's function at the bedside in intensive care unit (ICU). These tests are quite useful in diagnosing cerebral complications, and establishing the vital and functional prognosis in ICU...
January 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28099139/quantitative-eeg-in-obstructive-sleep-apnea-syndrome-a-review-of-the-literature
#17
Szilvia Puskás, Norbert Kozák, Dóra Sulina, László Csiba, Mária Tünde Magyar
Obstructive sleep apnea syndrome (OSAS) is characterized by the recurrent cessation (apnea) or reduction (hypopnea) of airflow due to the partial or complete upper airway collapse during sleep. Respiratory disturbances causing sleep fragmentation and repetitive nocturnal hypoxia are responsible for a variety of nocturnal and daytime complaints of sleep apnea patients, such as snoring, daytime sleepiness, fatigue, or impaired cognitive functions. Different techniques, such as magnetic resonance imaging, magnetic resonance spectroscopy, and positron emission tomography, are used to evaluate the structural and functional changes in OSAS patients...
April 1, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28030932/usage-of-perioperative-anxiety-neuromarker-for-improving-the-quality-of-life-of-a-patient-operated-on-for-critical-stenosis-of-the-internal-carotid-artery
#18
Mariusz Trystuła, Paweł Półrola, Juri Kropotov
OBJECTIVE: The aim of the study was to find a neuromarker of perioperative anxiety in a patient with critical carotid stenosis through the use of neuromarkers in Quantitative EEG (QEEG) and Event Related Potentials (ERPs). The indirect purpose of the research was evaluation of improvement in the patient's quality of life. CASE STUDY: A 45-year-old woman was admitted to the Department of Vascular Surgery and Endovascular Interventions at the John Paul II Hospital in Krakow, with the diagnosis of critical internal carotid stenosis (over 80%), confirmed by Doppler Ultrasound and Angio-CT examinations...
December 23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/27965571/increase-of-eeg-spectral-theta-power-indicates-higher-risk-of-the-development-of-severe-cognitive-decline-in-parkinson-s-disease-after-3-years
#19
Vitalii V Cozac, Menorca Chaturvedi, Florian Hatz, Antonia Meyer, Peter Fuhr, Ute Gschwandtner
Objective: We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson's disease. Methods: We prospectively investigated 37 patients with Parkinson's disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at follow-up. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables [global relative median power (GRMP) spectra] were obtained by a fully automated processing of high-resolution EEG (256-channels)...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27922904/utilization-of-quantitative-eeg-trends-for-critical-care-continuous-eeg-monitoring-a-survey-of-neurophysiologists
#20
Christa B Swisher, Saurabh R Sinha
PURPOSE: Quantitative EEG (QEEG) can be used to assist with review of large amounts of data generated by critical care continuous EEG monitoring. This study aimed to identify current practices regarding the use of QEEG in critical care continuous EEG monitoring of critical care patients. METHODS: An online survey was sent to 796 members of the American Clinical Neurophysiology Society (ACNS), instructing only neurophysiologists to participate. RESULTS: The survey was completed by 75 neurophysiologists that use QEEG in their practice...
December 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
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