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https://www.readbyqxmd.com/read/29676600/searching-online-for-information-about-vaccination-assessing-the-influence-of-user-specific-cognitive-factors-using-eye-tracking
#1
Sabrina Heike Kessler, Arne Freya Zillich
In Germany, the Internet is gaining increasing importance for laypeople as a source of health information, including information about vaccination. While previous research has focused on the characteristics of online information about vaccination, this study investigated the influence of relevant user-specific cognitive factors on users' search behavior for online information about vaccination. Additionally, it examined how searching online for information about vaccination influences users' attitudes toward vaccination...
April 20, 2018: Health Communication
https://www.readbyqxmd.com/read/29675468/decline-of-genetic-diversity-in-ancient-domestic-stallions-in-europe
#2
Saskia Wutke, Edson Sandoval-Castellanos, Norbert Benecke, Hans-Jürgen Döhle, Susanne Friederich, Javier Gonzalez, Michael Hofreiter, Lembi Lõugas, Ola Magnell, Anna-Sapfo Malaspinas, Arturo Morales-Muñiz, Ludovic Orlando, Monika Reissmann, Alexandra Trinks, Arne Ludwig
Present-day domestic horses are immensely diverse in their maternally inherited mitochondrial DNA, yet they show very little variation on their paternally inherited Y chromosome. Although it has recently been shown that Y chromosomal diversity in domestic horses was higher at least until the Iron Age, when and why this diversity disappeared remain controversial questions. We genotyped 16 recently discovered Y chromosomal single-nucleotide polymorphisms in 96 ancient Eurasian stallions spanning the early domestication stages (Copper and Bronze Age) to the Middle Ages...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29675416/free-floating-mesothelial-cells-in-pleural-fluid-after-lung-surgery
#3
Arne Kienzle, Andrew B Servais, Alexandra B Ysasi, Barry C Gibney, Cristian D Valenzuela, Willi L Wagner, Maximilian Ackermann, Steven J Mentzer
Objectives: The mesothelium, the surface layer of the heart, lung, bowel, liver, and tunica vaginalis, is a complex tissue implicated in organ-specific diseases and regenerative biology; however, the mechanism of mesothelial repair after surgical injury is unknown. Previous observations indicated seeding of denuded mesothelium by free-floating mesothelial cells may contribute to mesothelial healing. In this study, we investigated the prevalence of mesothelial cells in pleural fluid during the 7 days following pulmonary surgery...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29674671/characteristics-determining-host-suitability-for-a-generalist-parasite
#4
Bård G Stokke, Irja I Ratikainen, Arne Moksnes, Eivin Røskaft, Karl Schulze-Hagen, David I Leech, Anders Pape Møller, Frode Fossøy
Host quality is critical for parasites. The common cuckoo Cuculus canorus is a generalist avian brood parasite, but individual females show strong preference for a specific host species. Here, we use three extensive datasets to investigate different host characteristics determining cuckoo host selection at the species level: (i) 1871 population-specific parasitism rates collected across Europe; (ii) 14 K cases of parasitism in the United Kingdom; and (iii) 16 K cases of parasitism in Germany, with data collected during the period 1735-2013...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29672302/mucosal-two-step-pathogenesis-in-gastroesophageal-reflux-disease-repeated-weakly-acidic-stimulation-and-activation-of-protease-activated-receptor-2-on-mucosal-interleukin-8-secretion
#5
Lukas Winkelsett, Peter Malfertheiner, Thomas Wex, Arne Kandulski
BACKGROUND: Activation of protease-activated receptor-2 (PAR2) is involved in the mucosal immune pathogenesis of gastroesophageal reflux disease (GERD) that is characterized by proinflammatory cytokines such as interleukin-8 (IL-8). PAR2 activation on epithelial cells induces epithelial IL-8 secretion and initiates mucosal inflammation. METHODS: A human primary esophageal epithelial cell model was established to investigate the effects of repeated stimulation with weakly acidic solutions and subsequent PAR2 activation...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672185/living-and-ageing-with-stroke-an-exploration-of-conditions-influencing-participation-in-social-and-leisure-activities-over-15-years
#6
Anna Norlander, Susanne Iwarsson, Ann-Cathrin Jönsson, Arne Lindgren, Eva Månsson Lexell
OBJECTIVE: To explore conditions influencing long-term participation in social and leisure activities among people who have had a stroke. METHODS: This study had a qualitative design, using a grounded theory methodology. Data collection was based on in-depth interviews performed 15 years after a first-ever stroke with 10 persons recruited from a population-based stroke cohort in Sweden. The study also included four family members. FINDINGS: Over time, the stroke meant a changed but gradually normalised life situation...
April 19, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29671387/positioning-europe-for-the-epitranscriptomics-challenge
#7
Michael Jantsch, Alessandro Quattrone, Mary O'Connell, Mark Helm, Michaela Frye, Manuel Macias-Gonzales, Marie Ohman, Stefan Ameres, Luc Willems, Francois Fuks, Anastasis Oulas, Stepanka Vanacova, Henrik Nielsen, Cecile Bousquet-Antonelli, Yuri Motorin, Jean-Yves Roignant, Nikolaos Balatsos, Andras Dinnyes, Pavel Baranov, Vincent Kelly, Ayelet Lamm, Gideon Rechavi, Mattia Pelizzola, Janis Liepins, Irina Holodnuka Kholodnyuk, Vanessa Zammit, Duncan Ayers, Finn Drablos, John Arne Dahl, Janusz Bujnicki, Carmen Jeronimo, Raquel Almeida, Monica Neagu, Marieta Costache, Jasna Bankovic, Bojana Banovic, Jan Kyselovic, Luis Miguel Valor, Stefan Selbert, Pinar Pir, Turan Demircan, Victoria Cowling, Matthias Schäfer, Walter Rossmanith, Denis Lafontaine, Alexandre David, Clement Carre, Frank Lyko, Raffael Schaffrath, Schraga Schwartz, Andre Verdel, Arne Klungland, Elzbieta Purta, Gordana Timotijevic, Fernando Cardona, Alberto Davalos, Ester Ballana, Donal O Carroll, Jernej Ule, Rupert Fray
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research...
April 19, 2018: RNA Biology
https://www.readbyqxmd.com/read/29671377/estimating-under-five-mortality-in-space-and-time-in-a-developing-world-context
#8
Jon Wakefield, Geir-Arne Fuglstad, Andrea Riebler, Jessica Godwin, Katie Wilson, Samuel J Clark
Accurate estimates of the under-five mortality rate in a developing world context are a key barometer of the health of a nation. This paper describes a new model to analyze survey data on mortality in this context. We are interested in both spatial and temporal description, that is wishing to estimate under-five mortality rate across regions and years and to investigate the association between the under-five mortality rate and spatially varying covariate surfaces. We illustrate the methodology by producing yearly estimates for subnational areas in Kenya over the period 1980-2014 using data from the Demographic and Health Surveys, which use stratified cluster sampling...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29671054/survivin-expression-in-head-and-neck-squamous-cell-carcinomas-is-frequent-and-correlates-with-clinical-parameters-and-treatment-outcomes
#9
Adrian Münscher, Sebastian Prochnow, Amit Gulati, Guido Sauter, Balazs Lörincz, Marco Blessmann, Henning Hanken, Arne Böttcher, Till Sebastian Clauditz
OBJECTIVES: Strong expression of survivin is associated with worse survival in many different tumours, and in cell culture, a correlation between radiation resistance and survivin expression can be seen. The potential of survivin expression as a prognostic/predictive marker or therapeutic target has not been examined in head and neck squamous cell carcinomas (HNSCC) yet. MATERIAL AND METHODS: Retrospective study of 452 tissue samples and clinical data from patients with squamous cell carcinomas of the larynx/hypopharynx (LSCC), oral cavity (OSCC) and oropharynx (OPSCC) treated in the University Medical Centre Hamburg-Eppendorf between 2002 and 2006...
April 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29668275/structural-basis-for-the-specific-cotranslational-incorporation-of-p-boronophenylalanine-into-biosynthetic-proteins
#10
André Schiefner, Lea Nästle, Marietta Landgraf, Andreas J Reichert, Arne Skerra
The site-specific incorporation of the non-natural amino acid p-boronophenylalanine (Bpa) into recombinant proteins enables the development of novel carbohydrate-binding functions as well as bioorthogonal chemical modification. To this end, Bpa is genetically encoded by an amber stop codon and cotranslationally inserted into the recombinant polypeptide chain at the ribosome by means of an artificial aminoacyl-tRNA synthetase (aaRS) in combination with a compatible suppressor tRNA. We describe the crystal structure of an aaRS specific for Bpa, which had been engineered on the basis of the TyrRS from M...
April 18, 2018: Biochemistry
https://www.readbyqxmd.com/read/29666250/developmentally-inspired-programming-of-adult-human-mesenchymal-stromal-cells-toward-stable-chondrogenesis
#11
Paola Occhetta, Sebastien Pigeot, Marco Rasponi, Boris Dasen, Arne Mehrkens, Thomas Ullrich, Ina Kramer, Sabine Guth-Gundel, Andrea Barbero, Ivan Martin
It is generally accepted that adult human bone marrow-derived mesenchymal stromal cells (hMSCs) are default committed toward osteogenesis. Even when induced to chondrogenesis, hMSCs typically form hypertrophic cartilage that undergoes endochondral ossification. Because embryonic mesenchyme is obviously competent to generate phenotypically stable cartilage, it is questioned whether there is a correspondence between mesenchymal progenitor compartments during development and in adulthood. Here we tested whether forcing specific early events of articular cartilage development can program hMSC fate toward stable chondrogenesis...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665323/introducing-a-novel-highly-prognostic-grading-scheme-based-on-tumour-budding-and-cell-nest-size-for-squamous-cell-carcinoma-of-the-uterine-cervix
#12
Moritz Jesinghaus, Johanna Strehl, Melanie Boxberg, Frido Brühl, Adrian Wenzel, Björn Konukiewitz, Anna M Schlitter, Katja Steiger, Arne Warth, Andreas Schnelzer, Marion Kiechle, Matthias W Beckmann, Aurelia Noske, Arndt Hartmann, Grit Mehlhorn, Martin C Koch, Wilko Weichert
A novel histopathological grading system based on tumour budding and cell nest size has recently been shown to outperform conventional (WHO-based) grading algorithms in several tumour entities such as lung, oral, and oesophageal squamous cell carcinoma (SCC) in terms of prognostic patient stratification. Here, we tested the prognostic value of this innovative grading approach in two completely independent cohorts of SCC of the uterine cervix. To improve morphology-based grading, we investigated tumour budding activity and cell nest size as well as several other histomorphological factors (e...
April 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29663397/what-explains-high-plant-richness-in-east-asia-time-and-diversification-in-the-tribe-lysimachieae-primulaceae
#13
Hai-Fei Yan, Cai-Yun Zhang, Arne A Anderberg, Gang Hao, Xue-Jun Ge, John J Wiens
What causes the disparity in biodiversity among regions is a fundamental question in biogeography, ecology, and evolutionary biology. Evolutionary and biogeographic processes (speciation, extinction, dispersal) directly determine species richness patterns, and can be studied using integrative phylogenetic approaches. However, the strikingly high richness of East Asia relative to other Northern Hemisphere regions remains poorly understood from this perspective. Here, for the first time, we test two general hypotheses (older colonization time, faster diversification rate) to explain this pattern, using the plant tribe Lysimachieae (Primulaceae) as a model system...
April 17, 2018: New Phytologist
https://www.readbyqxmd.com/read/29661271/antimicrobial-peptide-expression-in-a-wild-tobacco-plant-reveals-the-limits-of-host-microbe-manipulations-in-the-field
#14
Arne Weinhold, Elham Karimi Dorcheh, Ran Li, Natarajan Rameshkumar, Ian T Baldwin
Plant-microbe associations are thought to be beneficial for plant growth and resistance against biotic or abiotic stresses, but for natural ecosystems, the ecological analysis of microbiome function remains in its infancy. We used transformed wild tobacco plants ( Nicotiana attenuata ) which constitutively express an antimicrobial peptide (Mc-AMP1) of the common ice plant, to establish an ecological tool for plant-microbe studies in the field. Transgenic plants showed in planta activity against plant-beneficial bacteria and were phenotyped within the plants´ natural habitat regarding growth, fitness and the resistance against herbivores...
April 17, 2018: ELife
https://www.readbyqxmd.com/read/29661208/unmanipulated-haploidentical-in-comparison-with-matched-unrelated-donor-stem-cell-transplantation-in-patients-60-years-and-older-with-acute-myeloid-leukemia-a-comparative-study-on-behalf-of-the-alwp-of-the-ebmt
#15
Nicole Santoro, Myriam Labopin, Federica Giannotti, Gerard Ehninger, Dietger Niederwieser, Arne Brecht, Matthias Stelljes, Nicolaus Kröger, Herman Einsele, Matthias Eder, Michael Hallek, Bertram Glass, Jürgen Finke, Fabio Ciceri, Mohamad Mohty, Annalisa Ruggeri, Arnon Nagler
BACKGROUND: Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need. METHODS: We retrospectively compared non-T-cell-depleted Haplo (n = 250) to 10/10 MUD (n = 2589) in AML patients ≥ 60 years...
April 16, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29661132/transcriptional-development-of-phospholipid-and-lipoprotein-metabolism-in-different-intestinal-regions-of-atlantic-salmon-salmo-salar-fry
#16
Yang Jin, Rolf Erik Olsen, Mari-Ann Østensen, Gareth Benjamin Gillard, Sven Arild Korsvoll, Nina Santi, Arne Bjørke Gjuvsland, Jon Olav Vik, Jacob Seilø Torgersen, Simen Rød Sandve, Yngvar Olsen
BACKGROUND: It has been suggested that the high phospholipid (PL) requirement in Atlantic salmon (Salmo salar) fry is due to insufficient intestinal de-novo synthesis causing low lipoprotein (LP) production and reduced transport capacity of dietary lipids. However, in-depth ontogenetic analysis of intestinal PL and LP synthesis with the development of salmon has yet to be performed. Therefore, in this paper we used RNA-Seq technology to investigate the expression of genes involved in PL synthesis and LP formation throughout early developmental stages and associate insufficient expression of synthesis pathways in salmon fry with its higher dietary PL requirement...
April 16, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29660891/soil-microbial-communities-and-glyphosate-decay-in-soils-with-different-herbicide-application-history
#17
Keren Hernández Guijarro, Virginia Aparicio, Eduardo De Gerónimo, Martín Castellote, Eva L Figuerola, José Luis Costa, Leonardo Erijman
This study evaluates the glyphosate dissipation under field conditions in three types of soil, and aims to determine the importance of the following factors in the environmental persistence of herbicide: i) soil bacterial communities, ii) soil physicochemical properties, iii) previous exposure to the herbicide. A soil without previous record of GP application (P0) and two agricultural soils, with 5 and >10years of GP exposure (A5 and A10) were subjected to the application of glyphosate at doses of 3mg·kg-1 ...
April 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660756/use-of-palivizumab-in-germany-report-from-the-german-synagis%C3%A2-registry-2009-2016
#18
Arne Simon, Susanne Gehrmann, Gudrun Wagenpfeil, Stefan Wagenpfeil
BACKGROUND: Following national recommendations, palivizumab is administered in Germany to high-risk infants to prevent hospitalizations related to Respiratory Syncytial Virus infection. METHODS: In this post marketing observational study (German SYNAGIS™ Registry) data on risk factors and the clinical course of children, who received at least one palivizumab injection between 2009-2016 (01 September to June 30) were entered into an internet-based data entry system by the attending physicians after informed consent...
April 16, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29659962/low-dietary-folate-interacts-with-mthfd1-synthetase-deficiency-in-mice-a-model-for-the-r653q-variant-to-increase-incidence-of-developmental-delays-and-defects
#19
Karen E Christensen, Renata H Bahous, Wenyang Hou, Liyuan Deng, Olga V Malysheva, Erland Arning, Teodoro Bottiglieri, Marie A Caudill, Loydie A Jerome-Majewska, Rima Rozen
Background: Suboptimal folate intake, a risk factor for birth defects, is common even in areas with folate fortification. A polymorphism in methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), R653Q (MTHFD1 c.1958 G > A), has also been associated with increased birth defect risk, likely through reduced purine synthesis. Objective: We aimed to determine if the interaction of MTHFD1 synthetase deficiency and low folate intake increases developmental abnormalities in a mouse model for MTHFD1 R653Q...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659073/online-sexual-activity-involving-webcams-an-overview-of-existing-literature-and-implications-for-sexual-boundary-violations-of-children-and-adolescents
#20
Thula Koops, Arne Dekker, Peer Briken
Despite the relevance of the Internet and its increasing use for sexual purposes, research into online sexual activity (OSA) involving webcams is limited. Aside from positive experiences, OSA may implicate violations of sexual boundaries, reaching from minor issues to serious forms of sexual abuse. To provide a basis for a classification of sexual boundary violations online and a conceptualization of preventive measures, a systematic review of the literature on OSA involving webcams was conducted, resulting in publications from four thematic categories: webcam use in common OSA, psychopathological phenomena, sex work, and crime and indecency (commercial sexual exploitation, trafficking, and sexual boundary violations)...
March 2018: Behavioral Sciences & the Law
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