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Sara Kammerer, Monika Mueller-Eschner, Arne Lauer, Anna-Luisa Luger, Johanna Quick-Weller, Kea Franz, Patrick Harter, Joachim Berkefeld, Marlies Wagner
PURPOSE:  Intracranial subependymomas are rare, mostly asymptomatic tumours, which are often found incidentally and therefore did not receive much attention in previous literature. By being classified as benign grade I in the WHO classification of tumours of the central nervous system, they are given a special status compared to the other ependymal tumours. Tumor recurrences are a rarity, spinal "drop metastases" do not occur. While etiological, pathological and therapeutic characteristics have been subject of several publications over the last few decades and have meanwhile been well studied, the imaging characteristics are much less well received...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Nadine Pelzer, Mark A Louter, Erik W van Zwet, Dale R Nyholt, Michel D Ferrari, Arn Mjm van den Maagdenberg, Joost Haan, Gisela M Terwindt
Background Migraine is a complex genetic disorder that is brought about by multiple genetic and environmental factors. We aimed to assess whether migraine frequency is associated with genetic susceptibility. Methods We investigated in 2829 migraine patients (14% males) whether 'migraine frequency' (measured as the number of migraine days per month) was related to 'genetic load' (measured as the number of parents affected with migraine) using a validated web-based questionnaire. In addition, we investigated associations with age-at-onset, migraine subtype, use of acute headache medication, and comorbid depression...
January 1, 2018: Cephalalgia: An International Journal of Headache
Wadih Ghattas, Virginie Dubosclard, Arne Wick, Audrey Bendelac, Régis Guillot, Rémy Ricoux, Jean-Pierre Mahy
Artificial metalloenzymes are known to be promising tools for biocatalysis, but their recent compartmentalization has led to compatibly with cell components thus shedding light on possible therapeutic applications. We prepared and characterized artificial metalloenzymes based on the A2A adenosine receptor embedded in the cytoplasmic membranes of living human cells. The wild type receptor was chemically engineered into metalloenzymes by its association with strong antagonists that were covalently bound to copper(II) catalysts...
June 18, 2018: Journal of the American Chemical Society
Robin Holtedahl, Jens Ivar Brox, Arne Kristian Aune, Daniel Nguyen, May Arna Risberg, Ole Tjomsland
OBJECTIVE: To examine rates of publicly financed knee arthroscopic surgery in Norway between 2012 and 2016. DESIGN: Analysis of anonymised data from the National Patient Registry. INTERVENTIONS: Beginning in 2012, South-Eastern Norway Regional Health Authority implemented administrative measures to bring down rates of knee arthroscopy. Similar measures were not introduced in the other three Regional Health Authorities. MAIN OUTCOME MEASURES: We analysed annual national rates of publicly financed knee arthroscopies in 2012 and 2016...
June 15, 2018: BMJ Open
Pooja Jha, Molly T McDevitt, Rahul Gupta, Pedro M Quiros, Evan G Williams, Karim Gariani, Maroun B Sleiman, Leo Diserens, Adam Jochem, Arne Ulbrich, Joshua J Coon, Johan Auwerx, David J Pagliarini
The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD mouse population fed chow or high-fat diet and integrated these data with complementary multi-omics datasets. We identified several lipid species and lipid clusters with specific phenotypic and molecular signatures and, in particular, cardiolipin species with signatures of healthy and fatty liver...
June 7, 2018: Cell Systems
Pooja Jha, Molly T McDevitt, Emina Halilbasic, Evan G Williams, Pedro M Quiros, Karim Gariani, Maroun B Sleiman, Rahul Gupta, Arne Ulbrich, Adam Jochem, Joshua J Coon, Michael Trauner, David J Pagliarini, Johan Auwerx
The genetic regulation and physiological impact of most lipid species are unexplored. Here, we profiled 129 plasma lipid species across 49 strains of the BXD mouse genetic reference population fed either chow or a high-fat diet. By integrating these data with genomics and phenomics datasets, we elucidated genes by environment (diet) interactions that regulate systemic metabolism. We found quantitative trait loci (QTLs) for ∼94% of the lipids measured. Several QTLs harbored genes associated with blood lipid levels and abnormal lipid metabolism in human genome-wide association studies...
May 31, 2018: Cell Systems
Judith H Parkinson, Raoul Kutil, Jonas Kuppler, Robert R Junker, Wolfgang Trutschnig, Arne C Bathke
The problem of quantifying the overlap of Hutchinsonian niches has received much attention lately, in particular in quantitative ecology, from where it also originates. However, the niche concept has the potential to also be useful in many other application areas, as for example in economics. We are presenting a fully nonparametric, robust solution to this problem, along with exact shortcut formulas based on rank-statistics, and with a rather intuitive probabilistic interpretation. Furthermore, by deriving the asymptotic sampling distribution of the estimators, we are proposing the first asymptotically valid inference method, providing confidence intervals for the niche overlap...
June 15, 2018: International Journal of Biostatistics
Amund Riiser, Vidar Andersen, Carlo Castagna, Svein Arne Pettersen, Atle Saeterbakken, Christian Froyd, Einar Ylvisaker, Terje Naess Kjosnes, Vegard Fusche Moe
As of 2017, the international football federation introduced the change of direction ability test (CODA) and the 5×30 m sprint test for assistant referees (ARs) and continued the 6×40 m sprint test for field referees (FRs) as mandatory tests. The aim of this study was to evaluate the association between performance in these tests and running performance during matches at the top level in Norway. The study included 9 FRs refereeing 21 matches and 19 ARs observed 53 times by a local positioning system at three stadiums during the 2016 season...
June 14, 2018: International Journal of Sports Medicine
Joachim R Göthert, Roze Imsak, Michael Möllmann, Stefanie Kesper, Maria Göbel, Ulrich Dührsen, Arne Scholz, Ulrich Lücking, Matthias Baumann, Anke Unger, Carsten Schultz-Fademrecht, Bert Klebl, Jan Eickhoff, Axel Choidas, Jan Dürig
Onset of progression even during therapy with novel drugs remains an issue in chronic lymphocytic leukemia (CLL). Thus, there is ongoing demand for novel agents. Approaches targeting cyclin-dependent kinases (CDK) have reached the clinical trial stage. CDK9 mediating RNA transcriptional elongation is the evolving pivotal CLL CDK inhibitor target. However, more CDK9 selective compounds are desirable. Here, we describe the CDK9 inhibitor LDC526 displaying a low nanomolar biochemical activity against CDK9 and an at least 50-fold selectivity against other CDKs...
May 29, 2018: Oncotarget
Jörg Bormann, Cornelia Heinze, Christine Blum, Michael Mentges, Anke Brockmann, Arne Alder, Svenja Kim Landt, Brian Josephson, Daniela Indenbirken, Michael Spohn, Birte Plitzko, Sandra Loesgen, Michael Freitag, Wilhelm Schäfer
Infections of fungi by mycoviruses are often symptomless but sometimes also fatal as they perturb sporulation, growth, and, if applicable, virulence of the fungal host. Hypovirulence-inducing mycoviruses, therefore, represent a powerful mean to defeat fungal epidemics on crop plants. Infection with Fusarium graminearum virus China 9 (FgV-ch9), a dsRNA chrysovirus-like mycovirus, debilitates Fusarium graminearum , the causal agent of Fusarium Head Blight. In search for potential symptom alleviation or aggravation factors in F...
June 13, 2018: Journal of Virology
Michael E J Lean, Arne Astrup, Susan B Roberts
No abstract text is available yet for this article.
June 13, 2018: BMJ: British Medical Journal
Ingrid Liodden, Are Hugo Pripp, Arne Johan Norheim
BACKGROUND: Patients entering a treatment have expectancy to outcome based on their previous experience, the information received, and the credibility of the treatment. Once the treatment has started, patients may detect and interpret contextual cues and somatic state. Influenced and conditioned by positive or negative interpretations, their reappraisal may improve or worsen the treatment outcome. The aims were to investigate whether parental pre-treatment expectancies towards acupuncture differ compared to post-treatment expectancies, and assess predictors for possible change of parental expectancy...
June 14, 2018: BMC Complementary and Alternative Medicine
James R W Conway, Sean C Warren, David Herrmann, Kendelle J Murphy, Aurélie S Cazet, Claire Vennin, Robert F Shearer, Monica J Killen, Astrid Magenau, Pauline Mélénec, Mark Pinese, Max Nobis, Anaiis Zaratzian, Alice Boulghourjian, Andrew M Da Silva, Gonzalo Del Monte-Nieto, Arne S A Adam, Richard P Harvey, Jody J Haigh, Yingxiao Wang, David R Croucher, Owen J Sansom, Marina Pajic, C Elizabeth Caldon, Jennifer P Morton, Paul Timpson
Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancreatic ductal adenocarcinoma (PDAC) and identify a phenomenon whereby pronounced hypoxia-induced resistance is observed for three clinically relevant inhibitors. To address this clinical problem, we have mapped tumor hypoxia by both immunofluorescence and phosphorescence lifetime imaging of oxygen-sensitive nanoparticles and demonstrate that these hypoxic regions move transiently around the tumor...
June 12, 2018: Cell Reports
Synnøve Caspari, Maj-Britt Råholm, Berit Saeteren, Arne Rehnsfeldt, Britt Lillestø, Vibeke Lohne, Åshild Slettebø, Anne Kari Tolo Heggestad, Bente Høy, Lillemor Lindwall, Dagfinn Nåden
AIM AND OBJECTIVES: The aim of this article is to present results from interviews of older people living in nursing homes, on how they experience freedom. BACKGROUND: We know that freedom is an existential human matter, and research shows that freedom remains important throughout life. Freedom is also important for older people, but further research is needed to determine how these people experience their freedom. The background for this article was a Scandinavian study that occurred in nursing homes; the purpose of the study was to gain knowledge about whether the residents felt that their dignity was maintained and respected...
June 13, 2018: Journal of Clinical Nursing
Knut-Arne Wensaas, Jon Heron, Niamh Redmond, Sophie Turnbull, Hannah Christensen, Hannah Thornton, Tim J Peters, Peter S Blair, Alastair D Hay
Background: Little is known about respiratory tract infection (RTI) severity in children following consultation. Objectives: To investigate post-consultation symptom trajectories in children with acute cough and RTI and whether baseline characteristics predict trajectory group. Methods: Prospective cohort study of 2296 children (3 months-16 years) whose parents were invited to report cough severity and duration using a 7-point Likert scale...
April 20, 2018: Family Practice
Rumi Kotoky, Manobjyoti Bordoloi, Archana Yadav, Kashyap J Tamuli, Surovi Saikia, Partha P Dutta, Prodip P Khound, Siddhartha P Saikia
The essential oil extracted from fruit of Micromelum integrrimum were evaluated through gas chromatography and gas chromatography-mass spectroscopy. 52 compounds were identified from the fruit oil representing 99.98% of the oil. The major components of the total fruit oil are monoterpene hydrocarbons (72.23%), oxygenated monoterpenes (14.78%) and sesquiterpene (11.54%) which were predominated by terpinolene (32.21%), α-pinene (17.24%), β-pinene (17.24%), and camphene (4.05%). Moreover, other components that present in 1...
June 13, 2018: Natural Product Research
Eleonora Rossi, Eva Mracsko, Adam Papadimitropoulos, Nima Allafi, Dieter Reinhardt, Arne Mehrkens, Ivan Martin, Irene Knuesel, Arnaud Scherberich
Triggering receptor expressed on myeloid cells-2 (TREM-2), a transmembrane receptor expressed by macrophages, microglia and osteoclasts, plays a protective role in late-onset Alzheimer Disease (AD). To validate TREM-2 as a therapeutic target in AD, its potential secondary effect on bone homeostasis should be clarified. However, animal models and monolayer cultures of human cells were shown poorly predictive of TREM-2 function in human. Therefore, this study aimed to engineer a tridimensional in vitro model using human progenitors differentiated into osteoblasts and osteoclasts, recapitulating physiological bone homeostasis...
June 13, 2018: Tissue Engineering. Part C, Methods
Arne Høiseth
No abstract text is available yet for this article.
June 12, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Peter Wallner, Michael Kundi, Arne Arnberger, Renate Eder, Brigitte Allex, Lisbeth Weitensfelder, Hans-Peter Hutter
Cognitive functioning and academic performance of pupils depend on regular breaks from classroom work. However, it is unclear which settings during such breaks provide the best environment to restore cognitive performance and promote wellbeing of adolescent pupils. Therefore, we investigated the effects of staying in different urban green spaces during breaks. Sixty-four pupils (16⁻18 years old) participated in a cross-over experiment. They were placed into one of three settings (small park, larger park, forest) for one hour during a lunch break...
June 8, 2018: International Journal of Environmental Research and Public Health
Arne Kandulski, Lukas Moleda, Martina Müller-Schilling
Background: Due to the high prevalence and incidence of patients with gastroesophageal reflux disease (GERD), the diagnostic workup of patients with symptoms of GERD needs to be balanced between empiric antisecretory therapy and further functional assessment including endoscopy and reflux monitoring. Methods: This article is based on a literature review (PubMed, Medline) using the terms 'gastroesophageal reflux disease' or 'GERD' and 'diagnosis', 'therapy', or 'PPI' with special and critical analysis of the current 'Porto' consensus report...
April 2018: Visceral Medicine
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