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https://www.readbyqxmd.com/read/28646117/cyclin-dependent-kinase-9-is-a-novel-specific-molecular-target-in-adult-t-cell-leukemia-lymphoma
#1
Tomoko Narita, Takashi Ishida, Asahi Ito, Ayako Masaki, Shiori Kinoshita, Susumu Suzuki, Hisashi Takino, Takashi Yoshida, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Kazunori Imada, Yuetsu Tanaka, Takaori-Kondo Akifumi, Hiroshi Inagaki, Arne Scholz, Philip Lienau, Taruho Kuroda, Ryuzo Ueda, Shinsuke Iida
Cyclin-dependent kinase 9 (CDK9), a subunit of the positive transcription elongation factor b (P-TEFb) complex, regulates gene transcription elongation by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII).  The deregulation of CDK9/P-TEFb has important implications for many cancer types.  BAY 1143572 is a novel and highly selective CDK9/P-TEFb inhibitor currently being investigated in phase I studies. We evaluated the therapeutic potential of BAY 1143572 in adult T-cell leukemia/lymphoma (ATL)...
June 23, 2017: Blood
https://www.readbyqxmd.com/read/28645322/erratum-to-trends-in-antimicrobial-resistance-and-empiric-antibiotic-therapy-of-bloodstream-infections-at-a-general-hospital-in-mid-norway-a-prospective-observational-study
#2
Arne Mehl, Bjørn Olav Åsvold, Angela Kümmel, Stian Lydersen, Julie Paulsen, Ingvild Haugan, Erik Solligård, Jan Kristian Damås, Stig Harthug, Tom-Harald Edna
No abstract text is available yet for this article.
June 23, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28643493/identification-of-viridans-streptococci-with-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-by-an-in-house-method-and-a-commercially-available-system
#3
Catalina Suzana Stingu, Klaus Eschrich, Juliane Thiel, Toralf Borgmann, Reiner Schaumann, Arne C Rodloff
Two matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS)-based methods were compared for their ability to identify viridans streptococci. One approach employed a reference database and software developed in-house. All inhouse measurements were performed using an Autoflex II Instrument (Bruker Daltonics GmbH, Germany). The other system, a VITEK-MS (BioMérieux, France) was operated on the commercially available V2.0 Knowledge Base for Clinical Use database. Clinical isolates of viridans streptococci (n=184) were examined...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28642723/when-the-heat-is-on-the-effect-of-temperature-on-voter-behavior-in-presidential-elections
#4
Jasper Van Assche, Alain Van Hiel, Jonas Stadeus, Brad J Bushman, David De Cremer, Arne Roets
Hot temperatures lead to heightened arousal. According to excitation transfer theory, arousal can increase both antisocial and prosocial behavior, depending on the context. Although many studies have shown that hot temperatures can increase antisocial behavior, very few studies have investigated the relationship between temperature and prosocial behavior. One important prosocial behavior is voting. We analyzed state-level data from the United States presidential elections (N = 761). Consistent with excitation transfer theory, which proposes that heat-induced arousal can transfer to other activities and strengthen those activities, changes in temperature and voter turnout were positively related...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28641450/musculoskeletal-dysfunction-in-migraine-patients
#5
Kerstin Luedtke, Wiebke Starke, Arne May
Objective The aim of this project was to evaluate the prevalence and pattern of musculoskeletal dysfunctions in migraine patients using a rigorous methodological approach and validating an international consensus cluster of headache assessment tests. Methods A physiotherapist, blinded towards the diagnosis, examined 138 migraine patients (frequent episodic and chronic), recruited at a specialised headache clinic, and 73 age and gender matched healthy controls following a standardised protocol. Eleven tests, previously identified in an international consensus procedure, were used to evaluate cervical and thoracic musculoskeletal dysfunctions...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28640891/baculoviral-delivery-of-crispr-cas9-facilitates-efficient-genome-editing-in-human-cells
#6
Sanne Hindriksen, Arne J Bramer, My Anh Truong, Martijn J M Vromans, Jasmin B Post, Ingrid Verlaan-Klink, Hugo J Snippert, Susanne M A Lens, Michael A Hadders
The CRISPR/Cas9 system is a highly effective tool for genome editing. Key to robust genome editing is the efficient delivery of the CRISPR/Cas9 machinery. Viral delivery systems are efficient vehicles for the transduction of foreign genes but commonly used viral vectors suffer from a limited capacity in the genetic information they can carry. Baculovirus however is capable of carrying large exogenous DNA fragments. Here we investigate the use of baculoviral vectors as a delivery vehicle for CRISPR/Cas9 based genome-editing tools...
2017: PloS One
https://www.readbyqxmd.com/read/28640456/first-environmental-sample-containing-plasmid-mediated-colistin-resistant-esbl-producing-escherichia-coli-detected-in-norway
#7
Silje Bakken Jørgensen, Arne Søraas, Lotte Stenfors Arnesen, Truls Leegaard, Arnfinn Sundsfjord, Pål A Jenum
We hereby report a detection of the plasmid borne mcr-1 gene conferring colistin resistance in an extended-spectrum β-lactamase (ESBL) producing Escherichia coli ST10 strain retrieved from seawater at a public beach in Norway. The sample was collected in September 2010 and was investigated by whole-genome sequencing in 2016. This report illustrates that E. coli strains carrying plasmid-mediated colistin resistance genes have also reached areas where this drug is hardly used at all. Surveillance of colistin resistance in environmental, veterinary, and human strains is warranted also in countries where colistin resistance is rare in clinical settings...
June 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28638837/validation-of-a-novel-immunoline-assay-for-patient-stratification-according-to-virulence-of-the-infecting-helicobacter-pylori-strain-and-eradication-status
#8
Luca Formichella, Laura Romberg, Hannelore Meyer, Christian Bolz, Michael Vieth, Michael Geppert, Gereon Göttner, Christina Nölting, Wolfgang Schepp, Arne Schneider, Kurt Ulm, Petra Wolf, Ingrid Lisanne Holster, Ernst J Kuipers, Bernd Birkner, Erwin Soutschek, Markus Gerhard
Helicobacter pylori infection shows a worldwide prevalence of around 50%. However, only a minority of infected individuals develop clinical symptoms or diseases. The presence of H. pylori virulence factors, such as CagA and VacA, has been associated with disease development, but assessment of virulence factor presence requires gastric biopsies. Here, we evaluate the H. pylori recomLine test for risk stratification of infected patients by comparing the test score and immune recognition of type I or type II strains defined by the virulence factors CagA, VacA, GroEL, UreA, HcpC, and gGT with patient's disease status according to histology...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28637260/associations-of-obesity-and-lifestyle-with-the-risk-and-mortality-of-bloodstream-infection-in-a-general-population-a-15-year-follow-up-of-64%C3%A2-027-individuals-in-the-hunt-study
#9
Julie Paulsen, Åsa Askim, Randi Marie Mohus, Arne Mehl, Andrew Dewan, Erik Solligård, Jan Kristian Damås, Bjørn O Åsvold
Background: Bloodstream infections (BSI) cause considerable morbidity and mortality, and primary prevention should be a priority. Lifestyle factors are of particular interest since they represent a modifiable target. Methods: We conducted a prospective cohort study among participants in the population-based Norwegian HUNT2 Survey, where 64 027 participants were followed from 1995-97 through 2011 by linkage to prospectively recorded information on BSI at local and regional hospitals...
June 15, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28637042/visions-and-the-progress-of-science
#10
Arne Egesten, Heiko Herwald
No abstract text is available yet for this article.
June 22, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28636608/the-construct-of-sexual-openness-for-females-in-steady-intimate-relationships
#11
Diana Rausch, Arne Dekker, Martin Rettenberger
The analysis of open-minded attitudes towards sexuality in general requires a construct based on attitudinal dimensions. Although several existing studies involve sexual attitudes, they differ substantially and standardized conceptual work is missing. Thus, the authors introduce the latent variable sexual openness to develop a construct based on self-oriented attitudes towards different sexual topics. Available survey data of female German students in a steady relationship allowed providing a first empirical test for the applicability of this construct...
2017: PloS One
https://www.readbyqxmd.com/read/28636085/herbivore-performance-and-plant-defense-after-sequential-attacks-by-inducing-and-suppressing-herbivores
#12
Elisa Faria de Oliveira, Angelo Pallini, Arne Janssen
It is well known that herbivore-induced plant defence alter host plant quality and can affect the behavior and performance of later arriving herbivores. Effects of sequential attacks by herbivores that either suppress or induce plant defenses are less well studied. We sequentially infested leaves of tomato plants with a strain of the phytophagous spider mite Tetranychus urticae that induces plant defenses and the closely related Tetranychus evansi, which suppresses plant defenses. Plant quality was quantified through oviposition of both spider mite species and by measuring proteinase inhibitor activity using plant material that had been sequentially attacked by both herbivore species...
June 21, 2017: Insect Science
https://www.readbyqxmd.com/read/28635355/aberrant-wnt-signaling-a-special-focus-in-cns-diseases
#13
Mercedes Arnés, Sergio Casas Tintó
Wnt signals regulate cell proliferation, migration and differentiation during development, as well as synaptic transmission and plasticity in the adult brain. Abnormal Wnt signaling is central to a number of brain pathologies. We review here, the significance of this pathway focused in the contribution of the most frequent alterations in receptors, secretable modulators and downstream targets in Alzheimer's disease (AD) and Glioblastoma (GBM). β-catenin and GSK3 levels are pivotal in the neurodegeneration associated to AD contributing to memory deficits, tau phosphorylation, increased β-amyloid production and modulation of Apolipoprotein E in the brain...
June 21, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28633425/androgen-receptor-mutations-in-patients-with-castration-resistant-prostate-cancer-treated-with-apalutamide
#14
D E Rathkopf, M R Smith, C J Ryan, W R Berry, N D Shore, G Liu, C S Higano, J J Alumkal, R Hauke, R F Tutrone, M Saleh, E Chow Maneval, S Thomas, D S Ricci, M K Yu, C J de Boer, A Trinh, T Kheoh, R Bandekar, H I Scher, E S Antonarakis
Background: : Mutations in the androgen receptor (AR) ligand-binding domain (LBD), such as F877L and T878A, have been associated with resistance to next-generation AR-directed therapies. ARN-509-001 was a phase I/II study that evaluated apalutamide activity in castration-resistant prostate cancer (CRPC). Here we evaluated the type and frequency of 11 relevant AR-LBD mutations in apalutamide-treated CRPC patients. Patients and methods: : Blood samples from men with non-metastatic CRPC (nmCRPC) and metastatic CRPC (mCRPC) pre- or post abiraterone acetate and prednisone (AAP) treatment (≥6 months' exposure) were evaluated at baseline and disease progression in trial ARN-509-001...
June 15, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28633396/response-to-motor-output-variability-impairs-driving-ability-in-older-adults
#15
Arne Stinchcombe, Anne Dickerson, Bruce Weaver, Michel Bédard
No abstract text is available yet for this article.
June 14, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28632161/endogenous-retroviral-insertions-indicate-a-secondary-introduction-of-domestic-sheep-lineages-to-the-caucasus-and-central-asia-between-the-bronze-and-iron-age
#16
Oskar Schroeder, Norbert Benecke, Kai Frölich, Zuogang Peng, Kai Kaniuth, Leonid Sverchkov, Sabine Reinhold, Andrey Belinskiy, Arne Ludwig
Sheep were one of the first livestock species domesticated by humans. After initial domestication in the Middle East they were spread across Eurasia. The modern distribution of endogenous Jaagsiekte sheep retrovirus insertions in domestic sheep breeds suggests that over the course of millennia, successive introductions of improved lineages and selection for wool quality occurred in the Mediterranean region and most of Asia. Here we present a novel ancient DNA approach using data of endogenous retroviral insertions in Bronze and Iron Age domestic sheep from the Caucasus and Pamir mountain areas...
June 20, 2017: Genes
https://www.readbyqxmd.com/read/28631255/-make-osa-great-again-report-from-the-113th-american-thoracic-society-international-conference-2017-in-washington-dc
#17
Stephan Pramsohler, Arn H Eliasson, Nikolaus Netzer
No abstract text is available yet for this article.
June 20, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28630795/efficacy-of-oral-valacyclovir-treatment-in-a-case-with-acute-retinal-necrosis
#18
Mert Şimşek, Pınar Çakar Özdal, Kemal Tekin
Acute retinal necrosis (ARN) is a rapidly progressive disease with poor prognosis, leading to visual loss in most cases. Rapid diagnosis and early anti-viral treatment significantly affect the course and prognosis of the disease. In this case report, we present a 34-year-old female patient referred to our clinic with symptoms of blurred vision and ocular pain diagnosed as acute glaucoma elsewhere. A clinical diagnosis of ARN was made and anti-viral treatment was started immediately. We herein describe our treatment approach to this particular case and discuss previously reported treatment modalities...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28630579/effects-of-exercise-in-the-fasted-and-postprandial-state-on-interstitial-glucose-in-hyperglycemic-individuals
#19
Håvard Nygaard, Bent R Rønnestad, Daniel Hammarström, Gerd Holmboe-Ottesen, Arne T Høstmark
The purpose of the present study was to test if one bout of moderate exercise performed in either the fasted or the postprandial state affects glucose values measured over 22 hours. Twelve participants diagnosed with hyperglycemia not using antidiabetic medications underwent 3 test days in a randomized cross-over design encompassing one test day without exercise, one test day with 60 min of treadmill walking prior to breakfast, and one test day with an identical bout of exercise 30 min after the start of breakfast...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28630204/a-low-molecular-weight-alginate-oligosaccharide-disrupts-pseudomonal-microcolony-formation-and-enhances-antibiotic-effectiveness
#20
Manon F Pritchard, Lydia C Powell, Alison A Jack, Kate Powell, Konrad Beck, Hannah Florance, Julian Forton, Philip D Rye, Arne Dessen, Katja E Hill, David W Thomas
In chronic respiratory disease the formation of dense, 3-dimensional 'micro colonies' by Pseudomonas aeruginosa within the airway plays an important role in contributing to resistance to treatment. An in vitro biofilm model of pseudomonal microcolony formation using artificial sputum (AS) medium was established to study the effects of low molecular weight alginate oligomers (OligoG CF-5/20) on pseudomonal growth, microcolony formation and the efficacy of colistin. The studies employed clinical cystic fibrosis (CF) isolates (n=3) and reference non-mucoid and mucoid multi-drug resistant (MDR) CF isolates (n=7)...
June 19, 2017: Antimicrobial Agents and Chemotherapy
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