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https://www.readbyqxmd.com/read/28800210/rates-of-early-intervention-services-in-children-born-extremely-preterm-extremely-low-birthweight
#1
Ianthe S Mills, Lex W Doyle, Jeanie Ly Cheong, Gehan Roberts
AIM: To determine the rates of early intervention (EI) service use in extremely preterm (EP, <28 weeks' gestation) or extremely low birthweight (ELBW, <1000 g) infants between 1991 and 2013, and identify biological or socio-economic factors associated with receiving EI. METHODS: Participants comprised consecutive EP or ELBW survivors born in 1991-1992, 1997 or 2005 in Victoria, Australia, and randomly selected, matched term-born controls. The main outcome measure was parent-reported EI participation up to 8 years of age...
August 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28776460/upper-limb-function-kinematic-analysis-and-dystonia-assessment-in-children-with-spastic-diplegic-cerebral-palsy-and-periventricular-leukomalacia
#2
Roser Pons, Athanasios Vanezis, Helen Skouteli, Antigoni Papavasiliou, Magda Tziomaki, Dimitris Syrengelas, Nikolaos Darras
Assessment of upper limb function, kinematic analysis, and dystonia in patients with spastic diplegia cerebral palsy and periventricular leukomalacia. Seven children with spastic diplegia cerebral palsy and 8 controls underwent upper limb kinematics. Movement duration, average and maximum linear velocity, index of curvature, index of dystonia, and target accuracy and stability were analyzed. In the patients with spastic diplegia, Gross Motor Function and Manual Ability Classification Systems were determined, and spasticity and dystonia were rated using the Modified Ashworth and the Burke-Fahn-Marsden Dystonia scales respectively...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28767132/antenatal-corticosteroid-prophylaxis-in-singleton-and-multiple-pregnancies
#3
Luigi Gagliardi, Renato Lucchini, Roberto Bellù, Rinaldo Zanini
BACKGROUND: The effects of antenatal corticosteroids (ANS) in multiple pregnancies are disputed. In this article, we examined whether estimated effects differ in singletons and multiples and in small for gestational age (SGA) preterm infants. METHODS: We studied 17 073 singletons (81% treated with ANS) and 8274 multiples (86% treated) born at 24-33 weeks from the Italian Neonatal Network (2005-2013). We used Poisson regression models with robust variance to estimate adjusted risk ratios (RR) of in-hospital death, severe intraventricular haemorrhage (IVH), periventricular leukomalacia (PVL), and the composite outcome of severe IVH and death...
August 2, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28744069/alteration-in-the-number-and-integrity-of-white-matter-tracts-in-the-preterm-a-quantitative-diffusion-tensor-imaging-and-diffusion-fibre-tractography-in-children
#4
Ruma M Sreedharan, Subramonium Aiyappan, N Roy
PURPOSE: Periventricular white matter is most commonly injured in preterm babies with hypoxia. To assess white matter damage, we decided to perform diffusion tensor imaging (DTI) in preterm children with history of hypoxia and magnetic resonance imaging (MRI) features of periventricular leukomalacia (PVL) (PTH). We hypothesized that the PTH have reduced number of white matter fibres compared to age matched pre term children without hypoxia (PTHO), and also depending on the severity of PVL, there could be reduction in the number of fibres as well...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28735381/characterization-of-the-sensorimotor-rhythm-in-4-month-old-infants-born-at-term-and-premature
#5
Milene Roca-Stappung, Minerva Moguel-González, Thalía Fernández, Thalía Harmony, Omar Mendoza-Montoya, José Luis Marroquín, Salvador Ruiz-Correa, Lourdes Díaz-Comas, Gloria Otero-Ojeda
The sensorimotor rhythm (SMR) is an electroencephalographic rhythm associated with motor and cognitive development observed in the central brain regions during wakefulness in the absence of movement, and it reacts contralaterally to generalized and hemibody movements. The purpose of this work was to characterize the SMR of 4-month-old infants, born either healthy at term or prematurely with periventricular leukomalacia (PVL). Two groups of infants were formed: healthy and premature with PVL. Their electroencephalograms (EEGs) were recorded in four conditions: rest, free movement, right-hand grasping and left-hand grasping, in order to explore general reactivity to free movement and contralateral reactivity in hand-grasping conditions...
July 22, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28733681/gestational-age-specific-sex-difference-in-mortality-and-morbidities-of-preterm-infants-a-nationwide-study
#6
So-Yeon Shim, Su Jin Cho, Kyoung Ae Kong, Eun Ae Park
This study aims to determine whether male sex has adverse effect on mortality and morbidities in very low birth weight infants (VLBWI) <30 weeks of gestation and to ascertain this sex effect, stratified by gestational age, adjusting for perinatal risk factors. This is a population-based study from Korean Neonatal Network for VLBWI born at 23(+0) and 29(+6) weeks of gestation between January 2013 and December 2014. The primary outcome was gestation-specific sex difference in the occurrence of mortality, combined morbidities, and individual morbidity...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28731515/analysis-of-structure-function-network-decoupling-in-the-brain-systems-of-spastic-diplegic-cerebral-palsy
#7
Dongha Lee, Chongwon Pae, Jong Doo Lee, Eun Sook Park, Sung-Rae Cho, Min-Hee Um, Seung-Koo Lee, Maeng-Keun Oh, Hae-Jeong Park
Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure-function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting-state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients...
July 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28727900/head-midline-position-for-preventing-the-occurrence-or-extension-of-germinal-matrix-intraventricular-hemorrhage-in-preterm-infants
#8
REVIEW
Olga Romantsik, Maria Grazia Calevo, Matteo Bruschettini
BACKGROUND: Preterm birth is known to constitute the major risk factor for development of germinal matrix-intraventricular hemorrhage (GM-IVH). Head position may affect cerebral hemodynamics and thus may be involved indirectly in development of GM-IVH. Turning the head toward one side may functionally occlude jugular venous drainage on the ipsilateral side while increasing intracranial pressure and cerebral blood volume. Thus, it has been suggested that cerebral venous pressure is reduced and hydrostatic brain drainage improved if the patient is in supine midline position with the bed tilted 30°...
July 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28724325/use-and-timing-of-surfactant-administration-impact-on-neonatal-outcomes-in-extremely-low-gestational-age-infants-born-in-canadian-neonatal-intensive-care-units
#9
Amelie Stritzke, Khorshid Mohammad, Prakesh S Shah, Xiang Y Ye, Vineet Bhandari, Albert Akierman, Adele Harrison, Valerie Bertelle, Abhay Lodha
BACKGROUND: Use, timing and doses of surfactant in preterm infants are variable in practice in modern NICUs. OBJECTIVE: To explore the association between use and timing of surfactant administration and common neonatal adverse outcomes in preterm infants with gestational age (GA) < 28 weeks. MATERIAL AND METHODS: Neonates admitted to a participating Canadian Neonatal Network NICU between 2013 and 2015 were studied. Infants were divided into three groups based on surfactant administration: None, early (within 30 minutes of life), and late surfactant (> 30 minutes)...
July 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28699152/-characteristics-of-structural-injuries-in-pediatric-patients-with-focal-epilepsy-in-a-honduran-hospital
#10
A Ramirez-Izcoa, D Varela-Gonzalez, M I Fonseca
INTRODUCTION: Epilepsy is the most commonly occurring neurological disorder in the world. The study of structural brain lesions is important to understand the secondary complications. In Honduras there is little information on this topic. AIM: To determine the characteristics and proportion of structural brain lesions in paediatric patients with focal epilepsy at the Hospital Escuela Universitario. PATIENTS AND METHODS: A descriptive, cross-sectional, retrospective-prospective study...
August 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28698268/effects-of-volume-guaranteed-ventilation-combined-with-two-different-modes-in-preterm-infants
#11
Sezin Unal, Ebru Ergenekon, Selma Aktas, Nilgun Altuntas, Serdar Beken, Ebru Kazanci, Ferit Kulali, Ozlem Gulbahar, Ibrahim M Hirfanoglu, Esra Onal, Canan Turkyilmaz, Esin Koc, Yildiz Atalay
BACKGROUND: Volume-controlled ventilation modes have been shown to reduce duration of mechanical ventilation, incidence of chronic lung disease, failure of primary mode of ventilation, hypocarbia, severe intraventricular hemorrhage, pneumothorax, and periventricular leukomalacia in preterm infants when compared with pressure limited ventilation modes. Volume-guarantee (VG) ventilation is the most commonly used mode for volume-controlled ventilation. Assist control, pressure-support ventilation (PSV), and synchronized intermittent mandatory ventilation (SIMV) can be combined with VG; however, there is a lack of knowledge on the superiority of each regarding clinical outcomes...
July 11, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28676401/hv1-proton-channel-facilitates-production-of-ros-and-pro-inflammatory-cytokines-in-microglia-and-enhances-oligodendrocyte-progenitor-cells-damage-from-oxygen-glucose-deprivation-in-vitro
#12
Ying Yu, Zhiyuan Yu, Minjie Xie, Wei Wang, Xiang Luo
The contribution of microglial activation to oligodendrocyte precursor cell (OPC) damage in the brain is considered to be a principal pathophysiological feature of periventricular leukomalacia (PVL). Nicotinamide adenine dinucleotide phosphate oxidase (NOX)-dependent reactive oxygen species (ROS) produced in microglia has been shown to be significantly toxic to OPCs. The voltage-gated proton channel Hv1 is selectively expressed in microglia and is essential for NOX-dependent ROS production in the central nervous system...
July 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28675256/-prevalence-and-risk-factors-for-periventricular-leukomalacia-in-preterm-infants-a-systematic-review
#13
G J Romero-Guzman, F Lopez-Munoz
INTRODUCTION: There is a huge disparity in the description of the prevalence and risk factors of periventricular leukomalacia in preterm infants. AIMS: To describe and compare, through a systematic review of the literature, the prevalence of periventricular leukomalacia in preterm infants, as well as to determine the main risk factors associated with its presentation. SUBJECTS AND METHODS: A systematic review was conducted consulting multiple databases of the last 20 years...
July 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28662947/rehospitalization-through-childhood-and-adolescence-association-with-neonatal-morbidities-in-infants-of-very-low-birth-weight
#14
Jacob Kuint, Liat Lerner-Geva, Gabriel Chodick, Valentina Boyko, Varda Shalev, Brian Reichman
OBJECTIVE: To evaluate the impact of major neonatal morbidities on the risks for rehospitalization in children and adolescents born of very low birth weight. STUDY DESIGN: An observational study was performed on data of the Israel Neonatal Network linked together with the Maccabi Healthcare Services medical records. After discharge from the neonatal intensive care unit, 6385 infants of very low birth weight born from 1995 to 2012 were registered with Maccabi Healthcare Services and formed the study cohort...
June 26, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28661514/delivery-room-resuscitation-and-adverse-outcomes-among-very-low-birth-weight-preterm-infants
#15
S Arnon, T Dolfin, B Reichman, R H Regev, L Lerner-Geva, V Boyko, I Litmanovitz
OBJECTIVE: To evaluate risk factors and impact of delivery room cardiopulmonary resuscitation (DR-CPR) on very low birth weight (VLBW) preterm infants. STUDY DESIGN: A national, population-based, observational study evaluating risk factors and short-term neonatal outcomes associated with DR-CPR among VLBW, extremely preterm infants (EPIs, 24 to 27 weeks' gestation) and very preterm infants (VPI, 28 to 31 weeks' gestation) born in 1995 to 2010. RESULTS: Among 17 564 VLBW infants, 636 (3...
June 29, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28658720/enteral-lactoferrin-supplementation-for-prevention-of-sepsis-and-necrotizing-enterocolitis-in-preterm-infants
#16
REVIEW
Mohan Pammi, Gautham Suresh
BACKGROUND: Lactoferrin, a normal component of human colostrum and milk, can enhance host defenses and may be effective for prevention of sepsis and necrotizing enterocolitis (NEC) in preterm neonates. OBJECTIVES: Primary objective 1. To assess the safety and effectiveness of lactoferrin supplementation to enteral feeds for prevention of sepsis and NEC in preterm neonates Secondary objectives 1. To determine the effects of lactoferrin supplementation to enteral feeds to prevent neonatal sepsis and/or NEC on duration of positive-pressure ventilation, development of chronic lung disease (CLD) or periventricular leukomalacia (PVL), length of hospital stay to discharge among survivors, and adverse neurological outcomes at two years of age or later2...
June 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28648484/confusions-in-nomenclature-periventricular-leukomalacia-and-white-matter-injury-identical-distinct-or-overlapping
#17
Joseph J Volpe
No abstract text is available yet for this article.
May 24, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28643657/impact-of-clinical-and-or-histological-chorioamnionitis-on-neurodevelopmental-outcomes-in-preterm-infants-a-literature-review
#18
REVIEW
E Maisonneuve, P-Y Ancel, L Foix-L'Hélias, S Marret, G Kayem
OBJECTIVE: To determine the impact of clinical and/or histological chorioamnionitis on neurodevelopmental outcomes in premature infants. METHODS: A review of the literature appeared in PubMed between 1997 and 2016 was conducted to examine the association between clinical and/or histological chorioamnionitis and neurologic impairment in the neonates (intraventricular hemorrhage, periventricular leukomalacia and white matter damage) and in infants (cerebral palsy and neurodevelopmental delay)...
April 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28636872/long-term-postnatal-steroid-effect-in-very-low-birth-weight-infants
#19
YoungAh Youn, Cheong-Jun Moon, In Kyung Sung
We examined whether hydrocortisone exposure≤1week in very low birth weight infants (VLBWI) was associated with poor neurodevelopmental outcomes at corrected 18months. Further, the clinical factors associated with worse long term outcome were also evaluated. Of a total of 191 VLBWI, the clinical data for these infants relating were retrospectively collected for analysis. Among the 191 VLBWI, 115 (60.2%) infants were exposed to early postnatal hydrocortisone≤1week of life in our NICU of Seoul St. Mary's Hospital, The Catholic University of Korea between December 2012 and December 2014...
June 19, 2017: Steroids
https://www.readbyqxmd.com/read/28635418/infantile-spasms-and-injuries-of-prematurity-short-term-treatment-based-response-and-long-term-outcomes
#20
Adam Wallace, Victoria Allen, Kristen Park, Kelly Knupp
The association of infantile spasms and periventricular leukomalacia and/or intraventricular hemorrhage is well documented. Data regarding early treatment-based and long-term outcomes are limited. A retrospective chart review identified children with infantile spasms born prematurely (<37 weeks) with diagnoses of periventricular leukomalacia and/or intraventricular hemorrhage. Thirteen children were included. Median gestational age was 30 weeks and age of onset of infantile spasms was 8 months. Nine children had intraventricular hemorrhage, 10 had periventricular leukomalacia, and 6 children had both...
September 2017: Journal of Child Neurology
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