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https://www.readbyqxmd.com/read/27921445/risk-of-neonatal-and-childhood-morbidity-among-preterm-infants-exposed-to-marijuana
#1
Sarah K Dotters-Katz, Marcela C Smid, Tracy A Manuck, Torri D Metz
BACKGROUND: Limited data exist regarding the neonatal and neurodevelopmental outcomes of infants exposed to marijuana (MJ) in-utero, particularly among preterm infants. We hypothesized that MJ-exposed preterm infants would have worse neonatal and childhood developmental outcomes compared to MJ-unexposed infants. METHODS: Secondary analysis of multicenter randomized-controlled trial of antenatal magnesium sulfate for prevention of cerebral palsy was conducted. Singleton non-anomalous infants delivered <35 weeks exposed to MJ in-utero were compared to MJ-unexposed...
December 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27894120/end-of-life-care-and-survival-without-major-brain-damage-in-newborns-at-the-limit-of-viability
#2
Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, José Ángel García Hernández, Josep Figueras Aloy, Alfredo García-Alix Pérez
BACKGROUND: The probabilities of survival and survival without major brain damage (MBD) are low in newborns at the limit of viability. Survival without MBD constitutes a major concern for parents and professionals. OBJECTIVES: To know the probabilities of survival without MBD in newborns ≤26 weeks' gestational age (GA) relative to the total number of survivors, whether these probabilities vary with GA, and how end-of-life (EoL) decisions influence these results...
November 29, 2016: Neonatology
https://www.readbyqxmd.com/read/27859836/outcome-in-monochorionic-twin-pregnancies-with-selective-intrauterine-growth-restriction-according-to-the-umbilical-artery-doppler-pattern-of-the-smaller-twin-a-systematic-review-and-meta-analysis
#3
REVIEW
Danilo Buca, Giorgio Pagani, Giuseppe Rizzo, Alessandra Familiari, Maria Elena Flacco, Lamberto Manzoli, Marco Liberati, Francesco Fanfani, Giovanni Scambia, Francesco D'Antonio
OBJECTIVE: To explore the outcome of monochorionic (MC) twin pregnancies affected by selective intra-uterine growth restriction (sIUGR) according to the umbilical artery Doppler pattern of the smaller twin. METHODS: Medline, Embase, Cinhal and ClinicalTrials.gov databases (2000-2016) were searched. sIUGR was defined as the presence of one twin with estimated fetal weight and/or abdominal circumference less than 10(th) or 5(th) percentile and classified according to the umbilical artery Doppler flow pattern of the smaller twin (type I: persistently positive, type II: persistently absent/reversed, type III: intermittently absent/reversed)...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27857787/a-study-of-neurosonogram-abnormalities-clinical-correlation-with-neurosonogram-findings-and-immediate-outcome-of-high-risk-neonates-in-neonatal-intensive-care-unit
#4
Niranjan Nagaraj, Pramod Kumar Berwal, Anusha Srinivas, Ramnarayan Sehra, Sarika Swami, Prathyusha Jeevaji, Gotam Swami, Lokesh Choudary, Ayush Berwal
BACKGROUND: Neonatal sonography of the brain is now an essential part of newborn care, particularly in high risk and unstable premature infants. Cranial ultrasound is the most available and easily repeatable imaging technique for the neonatal brain showing brain development and the most frequently occurring forms of cerebral injury in the preterm and terms. This study aims to assess the importance of cranial ultrasound as an investigatory modality for high-risk neonates and to find out the morphology of various cerebral lesions and correlate clinically...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27857456/magnetic-resonance-imaging-spectrum-of-perinatal-hypoxic-ischemic-brain-injury
#5
Binoj Varghese, Rose Xavier, V C Manoj, M K Aneesh, P S Priya, Ashok Kumar, V K Sreenivasan
Perinatal hypoxic-ischemic brain injury results in neonatal hypoxic-ischemic encephalopathy and serious long-term neurodevelopmental sequelae. Magnetic resonance imaging (MRI) of the brain is an ideal and safe imaging modality for suspected hypoxic-ischemic injury. The pattern of injury depends on brain maturity at the time of insult, severity of hypotension, and duration of insult. Time of imaging after the insult influences the imaging findings. Mild to moderate hypoperfusion results in germinal matrix hemorrhages and periventricular leukomalacia in preterm neonates and parasagittal watershed territory infarcts in full-term neonates...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27777426/survival-and-neurodevelopmental-outcomes-of-very-low-birth-weight-infants-in-a-regional-core-hospital-in-kochi-japan
#6
Hidehiko Maruyama, Yusei Nakata, Akane Kanazawa, Kiyoshi Kikkawa
We sought to clarify the survival and neurodevelopmental outcomes of very low birth weight infants (VLBWIs) and to identify risk factors for death or neurodevelopmental impairment (NDI) in VLBWIs at our hospital. The total study population was 217 infants born in 2005-2012 weighing 1,500 g. We compared their outcomes with those from previous reports analyzed the causes of death. Risk factors for death after discharge or NDI were evaluated by a multivariate logistic regression analysis. The incidences of death or NDI reported revealed in this study and the database of Neonatal Research Network of Japan were 25...
October 2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27764900/evaluation-of-long-term-neurodevelopment-in-twin-twin-transfusion-syndrome-after-laser-therapy
#7
Nicolas Sananès, Victor Gabriele, Anne Sophie Weingertner, Rodrigo Ruano, Magdalena Sanz-Cortes, Adrien Gaudineau, Bruno Langer, Israël Nisand, Chérif Youssef Akladios, Romain Favre
OBJECTIVE: The primary objective of our study was to evaluate the long-term neurodevelopment outcome after laser surgery for twin-twin transfusion syndrome (TTTS). The secondary objective was to identify perinatal prognostic factors associated with neurodevelopmental impairment. METHOD: This was a single-center cohort prospective study carried out in pregnancies complicated by TTTS and treated by laser. Neurodevleopmental assesment included the administration of Ages and Stages Questionnaires® (ASQ), for the infants between 2 and 5 years of age...
October 20, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27763965/evaluation-of-cognitive-function-when-hearing-one-s-own-name-in-patients-with-brain-injuries-in-early-developmental-stages
#8
Kaori Tamura, Takaaki Mizuba, Tsuyoshi Okamoto, Mayumi Matsufuji, Sachio Takashima, Keiji Iramina
INTRODUCTION: The level of residual cognitive function in patients with early brain injury is a key factor limiting rehabilitation and the quality of life. Although understanding residual function is necessary for appropriate rehabilitation, the extent of its effects on cognitive improvement remains unknown. The present study evaluated cognitive function in patients with severe motor and intellectual disabilities after early brain injuries due to cerebral hemorrhage (CH) or periventricular leukomalacia (PVL)...
October 18, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27737654/effectiveness-and-cost-effectiveness-of-routine-third-trimester-ultrasound-screening-for-intrauterine-growth-restriction-study-protocol-of-a-nationwide-stepped-wedge-cluster-randomized-trial-in-the-netherlands-the-iris-study
#9
Jens Henrichs, Viki Verfaille, Laura Viester, Myrte Westerneng, Bert Molewijk, Arie Franx, Henriette van der Horst, Judith E Bosmans, Ank de Jonge, Petra Jellema
BACKGROUND: Intrauterine growth retardation (IUGR) is a major risk factor for perinatal mortality and morbidity. Thus, there is a compelling need to introduce sensitive measures to detect IUGR fetuses. Routine third trimester ultrasonography is increasingly used to detect IUGR. However, we lack evidence for its clinical effectiveness and cost-effectiveness and information on ethical considerations of additional third trimester ultrasonography. This nationwide stepped wedge cluster-randomized trial examines the (cost-)effectiveness of routine third trimester ultrasonography in reducing severe adverse perinatal outcome through subsequent protocolized management...
October 13, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27723868/association-of-neurodevelopmental-outcomes-and-neonatal-morbidities-of-extremely-premature-infants-with-differential-exposure-to-antenatal-steroids
#10
Sanjay Chawla, Girija Natarajan, Seetha Shankaran, Athina Pappas, Barbara J Stoll, Waldemar A Carlo, Shampa Saha, Abhik Das, Abbot R Laptook, Rosemary D Higgins
Importance: Many premature infants are born without exposure to antenatal steroids (ANS) or with incomplete courses. This study evaluates the dose-dependent effect of ANS on rates of neonatal morbidities and early childhood neurodevelopmental outcomes of extremely premature infants. Objective: To compare rates of neonatal morbidities and 18- to 22-month neurodevelopmental outcomes of extremely premature infants exposed to no ANS or partial or complete courses of ANS...
December 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27695644/neonatal-enterovirus-infection-case-series-of-clinical-sepsis-and-positive-cerebrospinal-fluid-polymerase-chain-reaction-test-with-myocarditis-and-cerebral-white-matter-injury-complications
#11
Frank H Morriss, Julie B Lindower, Heather L Bartlett, Dianne L Atkins, Jean O Kim, Jonathan M Klein, Bradley A Ford
Objective We describe five neonates with enteroviral (EV) infection to demonstrate central nervous system (CNS) and cardiac complications and report successful treatment of myocarditis with immunoglobulin intravenous (IVIG) in two. Study Design Case series identified during three enteroviral seasons in one neonatal intensive care unit (NICU) by cerebral spinal fluid (CSF) reverse transcriptase polymerase chain reaction (PCR) testing for EV in neonates suspected to have sepsis, but with sterile bacterial cultures...
July 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27649293/trends-and-outcomes-of-patent-ductus-arteriosus-treatment-in-very-preterm-infants-in-canada
#12
Armend Lokku, Lucia Mirea, Shoo K Lee, Prakeshkumar S Shah
Objective To assess trends in patent ductus arteriosus (PDA) management and examine concurrent changes in neonatal mortality and morbidities. Methods This retrospective observational study examined infants born at 23 to 32 weeks' gestational age with PDA and admitted to a neonatal unit during 2006 to 2012. Multivariable logistic regression assessed trends in yearly PDA treatment rates and compared a composite outcome of mortality or any severe morbidity (bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, or necrotizing enterocolitis) between and within time periods and PDA treatments...
September 20, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27643988/isolated-cystic-periventricular-leukomalacia-differs-from-cystic-periventricular-leukomalacia-with-intraventricular-hemorrhage-in-prevalence-risk-factors-and-outcomes-in-preterm-infants
#13
Lan-Wan Wang, Yung-Chieh Lin, Yi-Fang Tu, Shan-Tair Wang, Chao-Ching Huang
BACKGROUND: Cystic periventricular leukomalacia (cPVL) is the most severe white matter injury and is often associated with intraventricular hemorrhage (IVH) in preterm infants. OBJECTIVE: The aim of this study was to investigate the prevalence, risk factors and neurodevelopmental outcomes of isolated cPVL and cPVL with low-grade and high-grade IVH in premature infants. METHODS: From 2001 to 2012, 9,964 infants with <31 weeks' gestational age (GA) admitted to Taiwan hospitals were enrolled...
September 16, 2016: Neonatology
https://www.readbyqxmd.com/read/27638717/pathogenesis-of-cerebral-palsy-through-the-prism-of-immune-regulation-of-nervous-tissue-homeostasis-literature-review
#14
Natalya Lisovska, Zholtay Daribayev, Yevgeny Lisovskyy, Kenzhe Kussainova, Lana Austin, Sholpan Bulekbayeva
BACKGROUND: The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability. Though the great progress in the neuroscience has been recently achieved, the pathogenesis of cerebral palsy is still poorly understood. METHODS: In this work, we reviewed available experimental and clinical data concerning the role of immune cells in pathogenesis of cerebral palsy. Maintaining of homeostasis in nervous tissue and its transformation in case of periventricular leukomalacia were analyzed...
September 14, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27627792/early-use-of-inhaled-nitric-oxide-in-preterm-infants-is-there-a-rationale-for-selective-approach
#15
Praveen Chandrasekharan, Rafal Kozielski, Vasantha H S Kumar, Munmun Rawat, Veena Manja, Changxing Ma, Satyan Lakshminrusimha
Inhaled nitric oxide (iNO) is being increasingly used in preterm infants < 34 weeks with hypoxemic respiratory failure (HRF) and/or pulmonary hypertension (PH). Objective To evaluate the risk factors, survival characteristics, and lung histopathology in preterm infants with PH/HRF. Methods Retrospective chart review was conducted to determine characteristics of 93 preterm infants treated with iNO in the first 28 days and compared with 930 matched controls. Factors associated with survival with preterm HRF and smooth muscle actin from nine autopsies were evaluated...
September 14, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27593438/decreased-variability-and-low-values-of-perfusion-index-on-day-one-are-associated-with-adverse-outcome-in-extremely-preterm-infants
#16
David Van Laere, John M O'Toole, Michiel Voeten, Joanne McKiernan, Geraldine B Boylan, Eugene Dempsey
OBJECTIVE: To develop new quantitative features for the Perfusion Index signal recorded continuously over the first 24 hours of life in a cohort of extremely low gestational age newborns and to assess the association of these features with normal and adverse short-term outcome. STUDY DESIGN: A cohort study of extremely low gestational age newborns. Adverse outcome was defined as early mortality before 72 hours of life, acquired severe periventricular-intraventricular hemorrhage, or severe cystic leukomalacia...
September 1, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27579318/volumetric-magnetic-resonance-imaging-study-of-brain-and-cerebellum-in-children-with-cerebral-palsy
#17
Piotr Kułak, Elżbieta Maciorkowska, Elżbieta Gościk
Introduction. Quantitative magnetic resonance imaging (MRI) studies are rarely used in the diagnosis of patients with cerebral palsy. The aim of present study was to assess the relationships between the volumetric MRI and clinical findings in children with cerebral palsy compared to control subjects. Materials and Methods. Eighty-two children with cerebral palsy and 90 age- and sex-matched healthy controls were collected. Results. The dominant changes identified on MRI scans in children with cerebral palsy were periventricular leukomalacia (42%) and posthemorrhagic hydrocephalus (21%)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27572420/impact-of-metabolic-acidemia-at-birth-on-neonatal-outcomes-in-infants-born-before-34-weeks-gestation
#18
Jamie L Morgan, David B Nelson, Brian M Casey, Steven L Bloom, Donald D McIntire, Kenneth J Leveno
PURPOSE: To examine prematurity-associated neonatal outcomes in early preterm infants with metabolic acidemia compared to those without such acidemia. METHODS: We performed a retrospective cohort analysis to assess the impact of metabolic acidemia on prematurity-associated complications in a large cohort of singleton live-born infants with complete umbilical cord gas analyses delivered between 24 0/7 and 33 6/7 weeks. Metabolic acidemia was defined as an umbilical artery pH less than 7...
September 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27567363/nifedipine-versus-placebo-in-the-treatment-of-preterm-prelabor-rupture-of-membranes-a-randomized-controlled-trial-assessment-of-perinatal-outcome-by-use-of-tocolysis-in-early-labor-apostel-iv-trial
#19
Tobias A J Nijman, Elvira O G van Vliet, Christiana A Naaktgeboren, Katrien Oude Rengerink, Thomas S de Lange, Caroline J Bax, Kitty W M Bloemenkamp, Jim van Eyck, Marjolein Kok, Hubertina C J Scheepers, Mallory Woiski, Arie Franx, Ben Willem J Mol, Martijn A Oudijk
OBJECTIVE: Preterm birth is the most common cause of neonatal morbidity and mortality. Around one third of preterm deliveries starts with preterm prelabor rupture of membranes (PPROM). The aim of this trial was to study the effect of prolonged tocolysis with nifedipine versus placebo in women with PPROM on perinatal outcome and prolongation of pregnancy. STUDY DESIGN: The Apostel IV was a nationwide multicenter randomized placebo controlled trial. We included women with PPROM without contractions between 24(+0) and 33(+6) weeks of gestation...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27567289/neuropathology-associated-with-diffuse-excessive-high-signal-intensity-abnormalities-on-magnetic-resonance-imaging-in-very-preterm-infants
#20
Nehal A Parikh, Christopher R Pierson, Jerome A Rusin
BACKGROUND: Diffuse excessive high signal intensity abnormality is the most common finding on term-equivalent age magnetic resonance imaging in extremely preterm infants. Yet its clinical significance remains a matter of debate, in part because of a lack of prior imaging-pathology correlational studies. PATIENT PRESENTATIONS: We present two 24-week-gestation infants with complicated clinical courses who died at 33 and 46 weeks postmenstrual age with magnetic resonance imaging evidence of diffuse excessive high signal intensity...
December 2016: Pediatric Neurology
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