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Rheumatoid arthritis treatment

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https://www.readbyqxmd.com/read/29777367/effects-of-crocin-on-inflammatory-activities-in-human-fibroblast-like-synoviocytes-and-collagen-induced-arthritis-in-mice
#1
Longjie Li, Haiseng Zhang, Shengli Jin, Chang Liu
Rheumatoid arthritis (RA) is a systemic autoimmune disease, characterized by the irreversible joint destruction resulted from the attack of inflammatory cells to the joints. Recent studies demonstrated that crocin is able to alleviate arthritis and suppress inflammatory responses, implying crocin as a potential promising antiarthritic agent. In this study, we confirmed the effect of crocin on RA and revealed its underlying mechanism by measuring lipopolysaccharides (LPS)-stimulated cytokine production in presence or absence of crocin...
May 18, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29776887/satisfaction-fulfillment-of-expectations-and-adherence-to-subcutaneous-biological-drugs-in-patients-with-rheumatoid-arthritis-arco-study
#2
Jaime Calvo-Alén, Paloma Vela, Sagrario Bustabad, Francisco Maceiras, Loreto Carmona, Luis Cea-Calvo
OBJECTIVES: In the ARCO study, adherence to subcutaneous biological agents by patients with rheumatoid arthritis improved with monthly administration. We assess whether adherence can be related to fulfillment of expectations and satisfaction with treatment. PATIENTS AND METHODS: Adherence was assessed by calculating the Medication Possession Ratio, and satisfaction and fulfillment of expectations using the «EXPRESAR» group questionnaire. RESULTS: In 346 patients, those who were satisfied/very satisfied with efficacy and tolerability were ≥80% and 64...
May 15, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29775734/defining-the-osteoarthritis-patient-back-to-the-future
#3
REVIEW
Geoffrey P Dobson, Hayley L Letson, Andrea Grant, Peter McEwen, Kaushik Hazratwala, Matthew Wilkinson, Jodie L Morris
The history of osteoarthritis (OA) is important because it can help broaden our perspective on past and present controversies. The naming of OA, beginning with Heberden's nodes, is itself a fascinating story. According to Albert Hoffa, R. Llewellyn Jones and Archibald Edward Garrod, the name OA was introduced in the mid-19th century by surgeon Richard von Volkmann who distinguished it from rheumatoid arthritis and gout. Others preferred the terms 'chronical rheumatism', 'senile arthritis', 'hypertrophic arthritis' or 'arthritis deformans'...
May 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29774953/dermoscopic-patterns-of-filiform-papillae-of-the-tongue-in-patients-with-and-without-connective-tissue-autoimmune-diseases
#4
José Manuel Díaz-González, María E Vega-Memije, Adalberto Mosqueda-Taylor, Víctor Noé García-Edgar, Juan Carlos Cuevas-González
BACKGROUND: Connective tissue autoimmune diseases (CTADs) constitute a group of conditions, including rheumatoid arthritis; systemic lupus erythematosus; mixed connective tissue disease; calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome; scleroderma; dermatomyositis; and Sjögren syndrome. There are few studies on the alterations in filiform papillae in CTAD. Thus, the objective of this work was to determine whether there are changes in the macroscopic and dermoscopic patterns of filiform papillae...
May 18, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29774784/moderate-alcohol-consumption-is-associated-with-increased-radiological-progression-in-women-but-not-in-men-with-early-rheumatoid-arthritis-results-from-the-espoir-cohort-%C3%A3-tude-et-suivi-des-polyarthrites-indiff%C3%A3-renci%C3%A3-es-r%C3%A3-centes
#5
F Sageloli, J L Quesada, B Fautrel, C Salliot, P Gaudin, A Baillet
OBJECTIVE: We conducted this study to determine whether alcohol consumption influences radiological progression in early rheumatoid arthritis (RA). METHOD: Patients fulfilling the European League Against Rheumatism/American College of Rheumatology 2010 criteria in the early arthritis cohort ESPOIR (Étude et Suivi des Polyarthrites Indifférenciées Récentes) were included in this study. Alcohol consumption was collected at baseline and at each visit. We classified alcohol consumption into three groups: abstinent (0 g/day), moderate (≤ 20 g/day for women, ≤ 30 g/day for men), and abuse (> 20 g/day for women, > 30 g/day for men)...
May 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29773003/antioxidant-action-of-an-aqueous-extract-of-royal-sun-medicinal-mushroom-agaricus-brasiliensis-agaricomycetes-in-rats-with-adjuvant-induced-arthritis
#6
Aline Cristine da Silva de Souza, Geferson de Almeida Gonсalves, Andréia Assunсão Soares, Anacharis B de Sá-Nakanishi, Ana Paula de Santi-Rampazzo, Maria Raquel Marсal Natali, Rosane Marina Peralta, Adelar Bracht
The purpose of this study was to evaluate possible effects of the administration of an aqueous Agaricus brasiliensis extract on the oxidative state of the liver, brain, and plasma in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Daily doses of 400 mg · kg-1 were administered by gavage for 23 days. This treatment produced significant diminutions in protein carbonylation and lipid damage in the liver, brain, and plasma. It also diminished the tissue reactive oxygen species and increased the antioxidant capacity of the plasma...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29772037/a-review-of-fabry-disease
#7
A Cinats, E Heck
The class of medications known as Janus kinase inhibitors block cytokine-mediated signaling via the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, which plays an important role in immunoregulation and normal cell growth. This class includes the drugs tofacitinib, approved for the treatment of rheumatoid arthritis, and ruxolitinib, approved for the treatment of myelofibrosis and polycythemia rubra vera. The most common adverse events (AEs) reported in patients taking tofacitinib are infections, whereas the most common AEs in patients taking ruxolitinib are anemia and thrombocytopenia...
May 2018: Skin Therapy Letter
https://www.readbyqxmd.com/read/29771924/obesity-and-response-to-anti-tumor-necrosis-factor-%C3%AE-agents-in-patients-with-select-immune-mediated-inflammatory-diseases-a-systematic-review-and-meta-analysis
#8
Siddharth Singh, Antonio Facciorusso, Abha G Singh, Niels Vande Casteele, Amir Zarrinpar, Larry J Prokop, Eduardo L Grunvald, Jeffrey R Curtis, William J Sandborn
OBJECTIVES: We sought to evaluate the association between obesity and response to anti-tumor necrosis factor-α (TNF) agents, through a systematic review and meta-analysis. METHODS: Through a systematic search through January 24, 2017, we identified randomized controlled trials (RCTs) or observational studies in adults with select immune-mediated inflammatory diseases-inflammatory bowel diseases (IBD), rheumatoid arthritis (RA), spondyloarthropathies (SpA), psoriasis and psoriatic arthritis (PsA)-treated with anti-TNF agents, and reporting outcomes, stratified by body mass index (BMI) categories or weight...
2018: PloS One
https://www.readbyqxmd.com/read/29770718/a-systematic-literature-review-comparing-methods-for-the-measurement-of-patient-persistence-and-adherence
#9
Carol A Forbes, Sohan Deshpande, Francesc Sorio-Vilela, Lucie Kutikova, Steven Duffy, Ioanna Gouni-Berthold, Emil Hagström
OBJECTIVES: A systematic literature review was conducted comparing different approaches estimating persistence and adherence in chronic diseases with polypharmacy of oral and subcutaneous treatments. METHODS: This work followed published guidance on performing systematic reviews. Twelve electronic databases and grey literature sources were used to identify studies and guidelines for persistence and adherence of oral and subcutaneous therapies in hypercholesterolemia, type 2 diabetes, hypertension, osteoporosis and rheumatoid arthritis...
May 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29770589/short-term-follow-up-of-antibiotic-loaded-articulating-cement-spacers-in-two-stage-revision-of-infected-total-knee-arthroplasty-a-case-series
#10
Meng-Qiang Tian, Xian-Teng Yang, Xiao-Bin Tian, Yun-Bo Sun, Yuan-Hui Duan, Li Sun
OBJECTIVE: Infection of total knee arthroplasty (TKA) is a rare but devastating complication. Two-stage revision is an effective treatment for late infected TKA. This study aimed to assess the short-term results of two-stage revision using articulating antibiotic-loaded spacers. METHODS: Twenty-five patients (10 men and 15 women) were diagnosed with late infections after TKA and treated with two-stage revision from April 2006 to August 2010; 19 of these patients had TKA for osteoarthritis and 6 for rheumatoid arthritis...
May 17, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29770511/liver-enzyme-abnormalities-of-inpatients-with-rheumatic-diseases-a-10-year-retrospective-study-in-a-korean-medicine-hospital
#11
Hyeonhoon Lee, Seunghoon Lee, Jung Won Kang, Jae-Dong Lee
Herbal medicines have been used as a treatment option for rheumatic disease (RD), but they often produce liver enzyme abnormality. This study examines the incidence of herb-induced liver injury (HILI) and the relationship between risk factors and liver enzyme abnormality (LEA) in inpatients with RD. HILI was analyzed using the Roussel Uclaf causality assessment method liver injury criteria and causality assessment. Multivariable analysis was performed to assess the relationship between patient characteristics and LEA in RD...
May 16, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29766809/associations-between-depressive-disorders-and-inflammatory-rheumatic-diseases
#12
Ozkan Varan, Hakan Babaoglu, Berna Goker
Depressive disorders, are not only common but also among the leading causes of disability worldwide. They are associated with increased incidences of various other diseases. It has been shown that in patients with autoimmune diseases, when depression coexists, the quality of life is worse and medical treatment and management is compromised. Depression-like symptoms, such as fatigue and disinterest are also common in inflammatory rheumatic diseases and often associated with poor quality of life. Medical therapy targeting inflammation results in alleviation of these symptoms in many patients...
May 15, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29766547/potent-and-selective-cc-chemokine-receptor-1-antagonists-labeled-with-carbon-13-carbon-14-and-tritium
#13
Bachir Latli, Matt Hrapchak, Maxim Cheveliakov, Jonathan T Reeves, Maurice Marsini, Carl A Busacca, Chris H Senanayake
1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide (1) and its analogs (2) and (3) are potent CCR1 antagonists intended for the treatment of rheumatoid arthritis. The detailed syntheses of these three compounds labeled with carbon-13 as well as the preparation of (1) and (2) labeled with carbon-14, and (1) labeled with tritium, are described.
May 15, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29765992/serological-immunoglobulin-free-light-chain-profile-in-myasthenia-gravis-patients
#14
Umberto Basile, Mariapaola Marino, Cecilia Napodano, Krizia Pocino, Paolo Emilio Alboini, Francesca Gulli, Amelia Evoli, Carlo Provenzano, Emanuela Bartoccioni
Background: Serological levels of free immunoglobulin light chains (FLCs), produced in excess of heavy chains during synthesis of immunoglobulins by plasma cells, can be considered a direct marker of B cell activity in different systemic inflammatory-autoimmune conditions and may represent a useful predictor of rituximab (RTX) therapeutic efficacy, as reported for rheumatoid arthritis and systemic lupus erythematosus. Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction with antibodies (abs) targeting the acetylcholine receptor (AChR) or the muscle-specific tyrosine kinase (MuSK), inducing muscle weakness and excessive fatigability...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29765782/biosimilars-have-arrived-rituximab
#15
REVIEW
Maria Greenwald, John Tesser, K Lea Sewell
A biosimilar is a biologic product that is highly similar to a licensed biologic ("originator") such that there are no clinically meaningful differences in safety, purity, or potency between the biosimilar and the originator. As patent protection and data exclusivity for the biologic rituximab expire, several potential biosimilars to rituximab are in development, which could soon lead to the availability of numerous rituximab biosimilars. Biosimilars are evaluated using thorough and rigorous analyses of the potential biosimilar versus the originator biological to confirm similar structure, function, and clinical efficacy as well as safety...
2018: Arthritis
https://www.readbyqxmd.com/read/29765703/effects-of-baricitinib-on-radiographic-progression-of-structural-joint-damage-at-1-year-in-patients-with-rheumatoid-arthritis-and-an-inadequate-response-to-conventional-synthetic-disease-modifying-antirheumatic-drugs
#16
Desirée van der Heijde, Maxime Dougados, Ying-Chou Chen, Maria Greenwald, Edit Drescher, Rena Klar, Li Xie, Inmaculada de la Torre, Terence P Rooney, Sarah L Witt, Douglas E Schlichting, Stephanie de Bono, Paul Emery
Background: Baricitinib was efficacious in a 24-week phase III study in patients with rheumatoid arthritis (RA) and an inadequate response to conventional synthetic disease-modifying anti rheumatic drugs (DMARDs) (csDMARDs) (RA-BUILD). Objectives: To evaluate radiographic progression of structural joint damage in RA-BUILD patients over 48 weeks of baricitinib treatment in the long-term extension study, RA-BEYOND. Methods: In RA-BUILD, patients were randomised to placebo, baricitinib 2 mg or 4 mg once daily, with rescue possible from week 16...
2018: RMD Open
https://www.readbyqxmd.com/read/29765444/sequentiality-of-treatment-in-the-rheumatoid-arthritis-drug-programme-in-the-years-2009-2014
#17
Małgorzata Tłustochowicz, Andrzej M Śliwczyński, Melania Brzozowska, Zbigniew Teter, Michał Marczak
Approximately 1% of the population suffers from rheumatoid arthritis (RA) worldwide (0.45% in Poland). The therapy consists of the use of disease-modifying antirheumatic drugs (DMARDs). Biologics are used in the form of the drug programme. Analysis of the NHF database demonstrated the sequence of conversion between drugs and time spent in a single treatment. In 2009, the patients would start the following treatments: adalimumab 5.8%; etanercept 14.4%; infliximab 23.1%; leflunomide 53.6%; rituximab 3%. After the first year 16% of patients changed therapy or abstained, and in the second year this situation affected 65% of patients...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764965/effect-of-treat-to-target-strategies-aiming-at-remission-of-arterial-stiffness-in-early-rheumatoid-arthritis-a-randomized-controlled-study
#18
Lydia Ho-Pui Tam, Qing Shang, Edmund Kwok-Ming Li, Priscilla Ching-Han Wong, Kitty Yan Kwok, Emily Wai-Lin Kun, Isaac Cheuk-Wan Yim, Violet Ka-Lai Lee, Ronald Man-Lung Yip, Steve Hin-Ting Pang, Virginia Weng-Nga Lao, Queenie Wah-Yan Mak, Isaac Tsz-Ho Cheng, Xerox Sze-Lok Lau, Tena Ka-Yan Li, Tracy Yaner Zhu, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVE: To determine the efficacy of 2 tight control treatment strategies aiming at Simplified Disease Activity Score (SDAI) remission (SDAI ≤ 3.3) compared to 28-joint count Disease Activity Score (DAS28) remission (DAS28 < 2.6) in the prevention of arterial stiffness in patients with early rheumatoid arthritis (RA). METHODS: This was an open-label study in which 120 patients with early RA were randomized to receive 1 year of tight control treatment. Group 1 (n = 60) aimed to achieve SDAI ≤ 3...
May 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29764485/the-role-of-inflammation-in-the-development-of-epilepsy
#19
REVIEW
Amna Rana, Alberto E Musto
Epilepsy, a neurological disease characterized by recurrent seizures, is often associated with a history of previous lesions in the nervous system. Impaired regulation of the activation and resolution of inflammatory cells and molecules in the injured neuronal tissue is a critical factor to the development of epilepsy. However, it is still unclear as to how that unbalanced regulation of inflammation contributes to epilepsy. Therefore, one of the goals in epilepsy research is to identify and elucidate the interconnected inflammatory pathways in systemic and neurological disorders that may further develop epilepsy progression...
May 15, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29763266/effectiveness-and-safety-of-celecoxib-for-the-treatment-of-rheumatoid-arthritis
#20
Kristian Sanchack, Sajeewane Seales, Paul Seales
No abstract text is available yet for this article.
May 1, 2018: American Family Physician
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