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https://www.readbyqxmd.com/read/29923311/primary-tissue-for-cellular-brain-repair-in-parkinson-s-disease-promise-problems-and-the-potential-of-biomaterials
#1
Niamh Moriarty, Clare L Parish, Eilís Dowd
The dopamine precursor, levodopa, remains the 'gold-standard' treatment for Parkinson's disease, and, although it provides superlative efficacy in the early stages of the disease, its long-term use is limited by the development of severe motor side effects and a significant abating of therapeutic efficacy. Therefore, there remains a major unmet clinical need for the development of effective neuroprotective, neurorestorative or neuroreparatory therapies for this condition. The relatively selective loss of dopaminergic neurons from the nigrostriatal pathway makes Parkinson's disease an ideal candidate for reparative cell therapies wherein the dopaminergic neurons that are lost in the condition are replaced through direct cell transplantation into the brain...
June 20, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29910564/early-results-of-fecal-microbial-transplantation-protocol-implementation-at-a-community-based-university-hospital
#2
Rodrigo Duarte-Chavez, Thomas R Wojda, Thomas B Zanders, Berhanu Geme, Gloria Fioravanti, Stanislaw P Stawicki
Introduction: Clostridium difficile (CD) is a serious and increasingly prevalent healthcare-associated infection. The pathogenesis of CD infection (CDI) involves the acquisition of CD with a concurrent disruption of the native gut flora. Antibiotics are a major risk although other contributing factors have also been identified. Clinical management combines discontinuation of the offending antibiotic, initiation of CD-specific antibiotic therapy, probiotic agent use, fecal microbiota transplantation (FMT), and surgery as the "last resort" option...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29907552/beyond-maximum-grade-modernising-the-assessment-and-reporting-of-adverse-events-in-haematological-malignancies
#3
REVIEW
Gita Thanarajasingam, Lori M Minasian, Frederic Baron, Franco Cavalli, R Angelo De Claro, Amylou C Dueck, Tarec C El-Galaly, Neil Everest, Jan Geissler, Christian Gisselbrecht, John Gribben, Mary Horowitz, S Percy Ivy, Caron A Jacobson, Armand Keating, Paul G Kluetz, Aviva Krauss, Yok Lam Kwong, Richard F Little, Francois-Xavier Mahon, Matthew J Matasar, María-Victoria Mateos, Kristen McCullough, Robert S Miller, Mohamad Mohty, Philippe Moreau, Lindsay M Morton, Sumimasa Nagai, Simon Rule, Jeff Sloan, Pieter Sonneveld, Carrie A Thompson, Kyriaki Tzogani, Flora E van Leeuwen, Galina Velikova, Diego Villa, John R Wingard, Sophie Wintrich, John F Seymour, Thomas M Habermann
Tremendous progress in treatment and outcomes has been achieved across the whole range of haematological malignancies in the past two decades. Although cure rates for aggressive malignancies have increased, nowhere has progress been more impactful than in the management of typically incurable forms of haematological cancer. Population-based data have shown that 5-year survival for patients with chronic myelogenous and chronic lymphocytic leukaemia, indolent B-cell lymphomas, and multiple myeloma has improved markedly...
June 12, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29906688/in-vitro-and-in-vivo-studies-of-gold-i-azolate-phosphane-complexes-for-the-treatment-of-basal-like-breast-cancer
#4
Valentina Gambini, Martina Tilio, Eunice Wairimu Maina, Cristina Andreani, Caterina Bartolacci, Junbiao Wang, Manuela Iezzi, Stefano Ferraro, Anna Teresa Ramadori, Oumarou Camille Simon, Stefania Pucciarelli, Guojun Wu, Q Ping Dou, Cristina Marchini, Rossana Galassi, Augusto Amici
Basal like breast cancer (BLBC) is a very aggressive subtype of breast cancer giving few chances of survival, against which cisplatin based therapy is a compromise among the anticancer activity, the resistance development and the severe side effects. With the aim of finding new anticancer agents alternative to cisplatin, seven gold(I) azolate/phosphane compounds were evaluated in vitro by MTT tests in human MDA-MB-231, human mammary epithelial HMLE cells overexpressing FoxQ1, and murine A17 cells as models of BLBC...
June 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29905054/-research-of-acellular-xenogeneic-nerve-combined-with-adipose-derived-stem-cells-and-platelet-rich-plasma-in-repair-of-rabbit-facial-nerve-injury
#5
Yanna Sun, Rongming Zhang, Xu Mao, Mengshu Zhang
Objective: To investigate the early effects of acellular xenogeneic nerve combined with adipose-derived stem cells (ADSCs) and platelet rich plasma (PRP) in repairing facial nerve injury in rabbits. Methods: The bilateral sciatic nerves of 15 3-month-old male Sprague-Dawley rats were harvested and decellularized as xenografts. The allogeneic ADSCs were extracted from the neck and back fat pad of healthy adult New Zealand rabbits with a method of digestion by collagenase type Ⅰ and the autologous PRP was prepared by two step centrifugation...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29896671/betaherpesvirus-complications-and-management-during-hematopoietic-stem-cell-transplantation
#6
Tetsushi Yoshikawa
Two of the four betaherpesviruses, Cytomegalovirus (CMV) and human herpesvirus 6B (HHV-6B), play an important role in opportunistic infections in hematopoietic stem cell transplant (HSCT) recipients. These viruses are ubiquitous in humans and can latently infect mononuclear lymphocytes, complicating the diagnosis of the diseases they cause. Although the detection of viral DNA in a patient's peripheral blood by real-time PCR is widely used for monitoring viral infection, it is insufficient for the diagnosis of virus-associated disease...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29895321/neural-stem-cell-therapy-for-subacute-and-chronic-ischemic-stroke
#7
REVIEW
Austin C Boese, Quan-Son Eric Le, Dylan Pham, Milton H Hamblin, Jean-Pyo Lee
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading cause of death and disability. Clinically, extensive injury from ischemic stroke results from ischemia-reperfusion (IR), which is accompanied by inflammation, blood-brain barrier (BBB) damage, neural cell death, and extensive tissue loss. Tissue plasminogen activator (tPA) is still the only US Food and Drug Administration-approved clot-lysing agent...
June 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29893056/con-steroids-should-not-be-withdrawn-in-transplant-recipients-with-autoimmune-hepatitis
#8
REVIEW
Eleni Theocharidou, Michael A Heneghan
Autoimmune liver diseases (AILD) can recur following liver transplantation despite immunosuppressive therapy, with implications for graft survival. Although the evidence is not robust, disease recurrence seems to occur in the presence of less intense and/or steroid-free immunosuppression in particular in the case of autoimmune hepatitis (AIH). The main risk factor for AIH recurrence is the severity of disease activity in the explant and potentially donor/recipient HLA-DR3 mismatch. The treatment for AIH recurrence includes reintroduction or increase in the dose of steroids with or without the addition of Azathioprine...
June 12, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29890512/open-liver-resection-laparoscopic-liver-resection-and-percutaneous-thermal-ablation-for-patients-with-solitary-small-hepatocellular-carcinoma-%C3%A2-30-mm-review-of-the-literature-and-proposal-for-a-therapeutic-strategy
#9
REVIEW
Luca Viganò, Andrea Laurenzi, Luigi Solbiati, Fabio Procopio, Daniel Cherqui, Guido Torzilli
BACKGROUND: Patients with a single hepatocellular carcinoma (HCC) ≤3 cm and preserved liver function have the highest likelihood to be cured if treated. The most adequate treatment methods are yet a matter that is debated. METHODS: We reviewed the literature about open anatomic resection (AR), laparoscopic liver resection (LLR), and percutaneous thermal ablation (PTA). RESULTS: PTA is effective as resection for HCC < 2 cm, when they are neither subcapsular nor perivascular...
June 11, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29882450/efficacy-and-safety-of-tacrolimus-combined-with-glucocorticoid-treatment-for-iga-nephropathy-a-meta-analysis
#10
Yong Zhang, Jun Luo, Bin Hu, Tean Ma
Objective As a classical immunosuppressant, tacrolimus (TAC) has been widely used in organ transplantation therapy, but the general benefits of TAC for the treatment of IgA nephropathy (IgAN) remain uncertain. We conducted a meta-analysis to examine the effects of TAC combined with glucocorticoid on IgAN. Methods We searched the information databases PubMed/Medline, Embase, Science Citation Index, Chinese Biomedical Literature and the Chinese databases VIP, CNKI and Wan Fang for randomized controlled trials of TAC combined with glucocorticoid as a therapy for IgAN...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29880053/indications-and-complications-of-inpatient-parenteral-nutrition-prescribed-to-children-in-a-large-tertiary-referral-hospital
#11
C Mantegazza, N Landy, G V Zuccotti, J Köglmeier
BACKGROUND: Parenteral Nutrition (PN) is prescribed to children with intestinal failure. Although life saving, complications are common. Recommendations for indications and constituents of PN are made in the 2005 guidelines by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). The aim of this study was to establish if the indications for prescribing PN in a tertiary children's hospital were appropriate, and to identify complications encountered. Data were compared to those published by the National Confidential Enquiry into patient outcome and death (NCEPOD) carried out in the United Kingdom in 2010...
June 8, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29879365/bone-marrow-stromal-cells-promote-innervation-of-bioengineered-teeth
#12
M Strub, L Keller, Y Idoux-Gillet, H Lesot, F Clauss, N Benkirane-Jessel, S Kuchler-Bopp
Transplantation of bone marrow mesenchymal stem cells (BMDCs) into a denervated side of the spinal cord was reported to be a useful option for axonal regeneration. The innervation of teeth is essential for their function and protection but does not occur spontaneously after injury. Cultured reassociations between dissociated embryonic dental mesenchymal and epithelial cells and implantation lead to a vascularized tooth organ regeneration. However, when reassociations were coimplanted with a trigeminal ganglion (TG), innervation did not occur...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29875956/macrophage-activation-syndrome-associated-with-griscelli-syndrome-type-2-case-report-and-review-of-literature
#13
Zakia Sefsafi, Brahim El Hasbaoui, Amina Kili, Aomar Agadr, Mohammed Khattab
Macrophage activation syndrome (MAS) is a severe and potentially fatal life-threatening condition associated with excessive activation and expansion of T cells with macrophages and a high expression of cytokines, resulting in an uncontrolled inflammatory response, with high levels of macrophage colony-stimulating factor and causing multiorgan damage. This syndrome is classified into primary (genetic/familial) or secondary forms to several etiologies, such as infections, neoplasias mainly hemopathies or autoimmune diseases...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29872960/unintentional-and-intentional-non-adherence-to-immunosuppressive-medications-in-renal-transplant-recipients
#14
Konstadina Griva, Hui Ling Michelle Neo, Anantharaman Vathsala
Background Non-adherence to immunosuppressive medications following renal transplantation is a risk factor for rejection and graft loss. Despite the dire consequences, adherence lapses, both unintentional and intentional, are common and poorly understood. Objective The present study sets to compare the rates and determinants of unintentional, intentional and overall self-reported non-adherence. Setting Outpatient clinic at the National University Centre for Organ Transplantation, Singapore. Method This was a cross-sectional survey administered to N = 152 renal transplant recipients...
June 6, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29872154/hiv-1-inhibition-in-cells-with-cxcr4-mutant-genome-created-by-crispr-cas9-and-piggybac-recombinant-technologies
#15
Shuai Liu, Qiankun Wang, Xiao Yu, Yilin Li, Yandan Guo, Zhepeng Liu, Fuyun Sun, Wei Hou, Chunmei Li, Li Wu, Deyin Guo, Shuliang Chen
The C-X-C chemokine receptor type 4 (CXCR4) is one of the major co-receptors for human immunodeficiency virus type 1 (HIV-1) entry and is considered an important therapeutic target. However, its function in maintaining the development of hematopoietic stem cells (HSC) makes it difficult to be used for HIV-1 gene therapy with HSC transplantation. A previous report showed that the natural CXCR4 P191A mutant inhibits HIV-1 infection without any defect in HSC differentiation, which could provide a basis for the development of new approaches for HIV-1 gene therapy...
June 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29871773/effect-of-low-dose-vs-standard-dose-valganciclovir-in-the-prevention-of-cytomegalovirus-disease-in-kidney-transplantation-recipients-a-systemic-review-and-meta-analysis
#16
S D Hwang, J H Lee, S W Lee, J K Kim, M-J Kim, J H Song
BACKGROUND: Valganciclovir is widely used to prevent post-transplant cytomegalovirus (CMV) infection in kidney transplant patients. However, the currently used dose remains controversial because the continuous use of this drug decreases kidney function and can induce leukopenia. OBJECTIVE: The purpose of this study was to measure the appropriate dose of valganciclovir required to prevent CMV infection. METHODS: A systematic review and meta-analysis were performed by using a random effects model...
June 2, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29863664/co-transplantation-of-human-ovarian-tissue-with-engineered-endothelial-cells-a-cell-based-strategy-combining-accelerated-perfusion-with-direct-paracrine-delivery
#17
Limor Man, Laura Park, Richard Bodine, Michael Ginsberg, Nikica Zaninovic, Glenn Schattman, Robert E Schwartz, Zev Rosenwaks, Daylon James
Infertility is a frequent side effect of chemotherapy and/or radiotherapy and for some patients, cryopreservation of oocytes or embryos is not an option. As an alternative, an increasing number of these patients are choosing to cryopreserve ovarian tissue for autograft following recovery and remission. Despite improvements in outcomes among patients undergoing auto-transplantation of cryopreserved ovarian tissue, efficient revascularization of grafted tissue remains a major obstacle. To mitigate ischemia and thus improve outcomes in patients undergoing auto-transplantation, we developed a vascular cell-based strategy for accelerating perfusion of ovarian tissue...
May 16, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29862994/the-role-of-undifferentiated-adipose-derived-stem-cells-in-peripheral-nerve-repair
#18
Rui Zhang, Joseph M Rosen
Peripheral nerve injuries impose significant health and economic consequences, yet no surgical repair can deliver a complete recovery of sensory or motor function. Traditional methods of repair are less than ideal: direct coaptation can only be performed when tension-free repair is possible, and transplantation of nerve autograft can cause donor-site morbidity and neuroma formation. Cell-based therapy delivered via nerve conduits has thus been explored as an alternative method of nerve repair in recent years...
May 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29862610/virologic-response-with-2-different-cidofovir-dosing-regimens-for-preemptive-treatment-of-adenovirus-dnaemia-in-pediatric-solid-organ-transplant-recipients
#19
Carlos H Guerra Sanchez, Cherish D Lorica, Kristopher L Arheart, Michelle M Perez, Akin Tekin, Ivan A Gonzalez
ADV is frequently seen in our pediatric SOT population. It presents in a variety of clinical presentation and can cause severe disease. In this population, there are very few studies to determine the safety of CDV as a potential therapeutic agent. We present the findings of our retrospective study evaluating the efficacy and safety of CDV as 2 separate dosing regimens. Regimen A uses the standard 5 mg/kg once a week (Regimen A), and the second uses the 1 mg/kg 3 times per week (Regimen B). Overall, the dosing regimen did not differ in nephrotoxicity, but Regimen B had a higher, although non-significant, rate of viral load clearance...
June 3, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29862092/tumor-necrosis-factor-alpha-inhibition-for-inflammatory-bowel-disease-after-liver-transplant-for-primary-sclerosing-cholangitis
#20
Ravish Parekh, Ahmed Abdulhamid, Sheri Trudeau, Nirmal Kaur
Background: Outcome data regarding the use of tumor necrosis factor alpha inhibitors (anti-TNF α ) in patients with inflammatory bowel disease (IBD) after liver transplant (LT) for primary sclerosing cholangitis (PSC) are scant. Methods: We performed a retrospective chart review to investigate outcomes among a series of post-liver-transplant PSC/IBD patients receiving anti-TNF α therapy at Henry Ford Health System ((HFHS), Detroit, MI). Results: A total of five patients were treated with anti-TNF α agents for IBD after LT for PSC from 1993 through 2015...
2018: Case Reports in Gastrointestinal Medicine
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