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https://www.readbyqxmd.com/read/29341939/the-quest-for-equivalence-of-test-results-the-pilgrimage-of-the-dutch-calibration-2-000-program-for-metrological-traceability
#1
REVIEW
Rob T P Jansen, Christa M Cobbaert, Cas Weykamp, Marc Thelen
Calibration 2.000 was initiated 20 years ago for standardization and harmonization of medical tests. The program also intended to evaluate adequate implementation of the In Vitro Diagnostics (IVD) 98/79/EC directive, in order to ensure that medical tests are fit-for-clinical purpose. The Calibration 2.000 initiative led to ongoing verification of test standardization and harmonization in the Netherlands using commutable external quality assessment (EQA)-tools and a type 1 EQA-design, where feasible. National support was guaranteed by involving all laboratory professionals as well as laboratory technicians responsible for EQA and quality officers...
January 17, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29341527/-recent-advances-in-internal-medicine
#2
Stephan Von Düring, Thomas Mavrakanas, Halima Muller, Steve Primmaz, Olivier Grosgurin, Martine Louis Simonet, Christophe Marti, Mathieu Nendaz, Jacques Serratrice, Jérome Stirnemann, Sebastian Carballo, Pauline Darbellay Farhoumand
In medicine, there are progresses which radically transform practices, change recommendations and win unanimous support in the medical community. There are some which divide, questioning principles that seemed established. There are also small advances, which can answer the questions that internists ask themselves in the daily care of their patients. Here are several articles published in 2017, read and commented for you by hospitalists, selected according to their impact on the medical world.
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29340887/toward-evidence-based-chinese-medicine-status-quo-opportunities-and-challenges
#3
Yao-Long Chen, Chen Zhao, Li Zhang, Bo Li, Chuan-Hong Wu, Wei Mu, Jia-Ying Wang, Ke-Hu Yang, You-Ping Li, Chiehfeng Chen, Yong-Yan Wang, Chen Wang, Zhao-Xiang Bian, Hong-Cai Shang
How to test the treatments of Chinese medicine (CM) and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of CM. For centuries, various approaches have been used to identify and measure the efficacy and safety of CM. However, the high-quality evidence related to CM that produced in China is still rare. Over the recent years, evidence-based medicine (EBM) has been increasingly applied to CM, strengthening its theoretical basis...
January 16, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29338973/asthma-copd-overlap-a-portuguese-survey
#4
E Padrão, D Araújo, A Todo Bom, C Robalo Cordeiro, J Correia de Sousa, J Cardoso, M Morais-Almeida, R Costa, F Pavão, R B Leite, A Marques
INTRODUCTION: The overlap between asthma and chronic obstructive pulmonary disease (COPD) (ACO) has been discussed for many years but clinical recommendations for this entity have been diverse. This study is intended to reach a consensus on diagnosis, treatment and patient orientation for ACO, within the Portuguese medical community. METHODS: This study was conducted by a multidisciplinary panel of experts from three distinct medical specialties (Pulmonology, Family Medicine and Immunoallergology)...
January 12, 2018: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29338743/the-prospective-and-concurrent-effect-of-exercise-on-health-related-quality-of-life-in-older-adults-over-a-3%C3%A2-year-period
#5
Helen-Maria Vasiliadis, Mathieu F Bélanger
BACKGROUND: It is not clear whether socioeconomic status influences health outcomes among older adults through its effect on physical activity. The aim of this study was to assess the effect of sex and neighborhood socio-economic status on the change in health related quality of life (HR-QOL) as a function of physical activity over a three-year period. METHODS: This cohort study included French-speaking community-dwelling older adults recruited in primary care practices in the province of Quebec and participating in the 'Étude sur la Santé des Ainés' (ESA)-Services study on the health of the elderly...
January 16, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29335210/privileged-scaffolds-as-mao-inhibitors-retrospect-and-prospects
#6
REVIEW
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
This review aims to be a comprehensive, authoritative, critical, and readable review of general interest to the medicinal chemistry community because it focuses on the pharmacological, chemical, structural and computational aspects of diverse chemical categories as monoamine oxidase inhibitors (MAOIs). Monoamine oxidases (MAOs), namely MAO-A and MAO-B represent an enormously valuable class of neuronal enzymes embodying neurobiological origin and functions, serving as potential therapeutic target in neuronal pharmacotherapy, and hence we have coined the term "Neurozymes" which is being introduced for the first time ever...
January 4, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29334977/ethnoecology-of-the-interchange-of-wild-and-weedy-plants-and-mushrooms-in-phur%C3%A3-pecha-markets-of-mexico-economic-motives-of-biotic-resources-management
#7
Berenice Farfán-Heredia, Alejandro Casas, Ana I Moreno-Calles, Eduardo García-Frapolli, Aída Castilleja
BACKGROUND: Interactions between societies and nature are regulated by complex systems of beliefs, symbolism, customs, and worldviews (kosmos), ecological knowledge (corpus), and management strategies and practices (praxis), which are constructed as product of experiences and communication of people throughout time. These aspects influence social relations, life strategies, and cultural identity, and all of them in turn influence and are influenced by local and regional patterns of interchange...
January 15, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29332593/facile-synthesis-crystal-structure-dft-calculation-and-biological-activities-of-4-2-fluorophenyl-3-3-methoxybenzyl-1h-1-2-4-triazol-5-4h-one-5
#8
Muhammad Saleem, Muhammad Rafiq, Yeon Ki Jeong, Dae Won Cho, Chong-Hyeak Kim, Sung-Yum Seo, Chang-Shik Choi, Seong-Karp Hong, Ki-Hwan Lee
BACKGROUND: In the past few decades, the design, synthesis and characterization of novel heterocyclic compounds with auspicious biological profile received the considerable attention of scientific community. Among them, the small and simple organic molecular backbone like triazole moiety have broad spectrum of applications in the medicinal as well as diagnostic areas. OBJECTIVE: The objective of present study was the synthesis, characterization and exploration of biological profile of 4-(2-fluorophenyl)-3-(3-methoxybenzyl)-1H-1,2,4-triazol-5(4H)-one (5)...
January 12, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29332007/impacts-of-canada-s-minimum-age-for-tobacco-sales-mats-laws-on-youth-smoking-behaviour-2000-2014
#9
Russell Clarence Callaghan, Marcos Sanches, Jodi Gatley, James K Cunningham, Michael Oliver Chaiton, Robert Schwartz, Susan Bondy, Claire Benny
BACKGROUND: Recently, the US Institute of Medicine has proposed that raising the minimum age for tobacco purchasing/sales to 21 years would likely lead to reductions in smoking behavior among young people. Surprisingly few studies, however, have assessed the potential impacts of minimum-age tobacco restrictions on youth smoking. OBJECTIVE: To estimate the impacts of Canadian minimum age for tobacco sales (MATS) laws on youth smoking behaviour. DESIGN: A regression-discontinuity design, using seven merged cycles of the Canadian Community Health Survey, 2000-2014...
January 13, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29330437/a-computational-assay-of-estrogen-receptor-%C3%AE-antagonists-reveals-the-key-common-structural-traits-of-drugs-effectively-fighting-refractory-breast-cancers
#10
Matic Pavlin, Angelo Spinello, Marzia Pennati, Nadia Zaffaroni, Silvia Gobbi, Alessandra Bisi, Giorgio Colombo, Alessandra Magistrato
Somatic mutations of the Estrogen Receptor α (ERα) occur with an up to 40% incidence in ER sensitive breast cancer (BC) patients undergoing prolonged endocrine treatments. These polymorphisms are implicated in acquired resistance, disease relapse, and increased mortality rates, hence representing a current major clinical challenge. Here, multi-microseconds (12.5 µs) molecular dynamics simulations revealed that recurrent ERα polymorphisms (i. e. L536Q, Y537S, Y537N, D538G) (mERα) are constitutively active in their apo form and that they prompt the selection of an agonist (active)-like conformation even upon antagonists binding...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330235/primary-care-physician-perspectives-about-antipsychotics-and-other-medications-for-symptoms-of-dementia
#11
J William Kerns, Jonathan D Winter, Katherine M Winter, Terry Boyd, Rebecca S Etz
BACKGROUND: Guidelines, policies, and warnings have been applied to reduce the use of medications for behavioral and psychological symptoms of dementia (BPSD). Because of rare dangerous side effects, antipsychotics have been singled out in these efforts. However, antipsychotics are still prescribed "off label" to hundreds of thousands of seniors residing in nursing homes and communities. Our objective was to evaluate how and why primary-care physicians (PCPs) employ nonpharmacologic strategies and drugs for BPSD...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29327992/digitalhub-a-repository-focused-on-the-future
#12
Violeta Ilik, Piotr Hebal, Anton Olson, Susan Wishnetsky, Joelen Pastva, Ramune Kubilius, Jonathan Shank, Karen Gutzman, Margarita Chung, Kristi Holmes
The DigitalHub scholarly repository was developed and launched at the Galter Health Sciences Library for the Feinberg School of Medicine and the greater Northwestern Medicine community. The repository was designed to allow scholars the ability to create, share, and preserve a range of citable digital outputs. This article traces the evolution of DigitalHub's development and engagement activities, highlighting project challenges, innovations, success stories, and the team-based approach that was employed to successfully achieve project goals...
January 2018: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/29327981/hiv-aids-outreach-curriculum-development-and-skills-training-to-health-and-information-professionals
#13
Gretchen M Kuntz, Nancy Schaefer, Hannah F Norton, Michele R Tennant
With funding from the National Library of Medicine HIV/AIDS Community Information Outreach Program (ACIOP), librarians at the University of Florida Health Sciences Libraries partnered with university and community groups to facilitate collaboration, develop new information resources, develop information-seeking skills, and raise general awareness surrounding HIV/AIDS risks, prevention, and treatment. This article describes the skills development elements of the project, including development and implementation of an HIV/AIDS information resource curriculum for health care providers, social services professionals, and public librarians within the project's partner organizations...
January 2018: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/29327395/effects-of-traditional-chinese-medicine-formula-on-ruminal-fermentation-enzyme-activities-and-nutrient-digestibility-of-beef-cattle
#14
Zhi Zhu, Zhen-Hui Song, Li-Ting Cao, Yong Wang, Wen-Zhang Zhou, Pei Zhou, Fu-Yuan Zuo
This study was conducted to evaluate effects of traditional Chinese medicine formula (TCMF) combined with several herbs on ruminal fermentation, enzyme activities and nutrient digestibility. Twenty finishing bulls were assigned to control or different TCMFs (Yufeisan-1, -2, -3; 2.5% dry matter (DM) in concentrate). Results showed that DM intake was higher (P < 0.05) in the Yufeisan-3 group than others. Compared to control, apparent digestibility of crude protein and neutral detergent fiber were increased (P < 0...
January 12, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29325839/the-effect-of-low-load-exercise-on-joint-pain-function-and-activities-of-daily-living-in-patients-with-knee-osteoarthritis
#15
Jason Peeler, Jacquie Ripat
BACKGROUND: Knee osteoarthritis has a lifetime risk of nearly one in two, with obese individuals being most susceptible. While exercise is universally recognized as a critical component for management, unsafe or ineffective exercise frequently leads to exacerbation of joint symptoms. AIM: Evaluate the effect of a 12week lower body positive pressure (LBPP) supported low-load treadmill walking program on knee pain, joint function, and performance of daily activities in patients with knee osteoarthritis (OA)...
January 8, 2018: Knee
https://www.readbyqxmd.com/read/29325630/towards-precision-medicine
#16
Tanya Bardakjian, Pedro Gonzalez-Alegre
The concept of precision medicine, also referred to as individualized or personalized medicine, has recently gained traction in scientific, medical, and public spheres, and is frequently mentioned as the next model of healthcare delivery. Its goal is to integrate unique information obtained from a given patient to customize the care provided to achieve the best possible outcome. Although precision medicine is not fully implemented yet, its application is slowly infiltrating clinical practice, and the dream of individualizing healthcare to each patient is now closer to being fulfilled...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29322939/public-health-psychopharmacology-a-new-research-discipline-comes-of-age
#17
C Barbui, G Ostuzzi, B Godman
Research evidence guiding the identification of pragmatic and effective actions aimed at improving the selection, availability, affordability and rational prescribing of medicines for mental disorders is sparse and inconsistent. In order to boost the development of new research, in this commentary we suggest to organise and classify all the activities in this area under a common theoretical framework and nomenclature, adopting the term 'public health psychopharmacology'. Public health psychopharmacology is proposed as a research discipline, based on contributions from the fields of regulatory science, health services research and implementation science...
February 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29321983/anti-paralytic-medicinal-plants-review
#18
REVIEW
Khaling Mikawlrawng, Roma Rani, Suresh Kumar, Ankur R Bhardwaj, Geeta Prakash
Paralysis is the loss of the ability of one or more muscles to move, due to disruption of signaling between the nervous system and muscles. The most common causes of paralysis are stroke, head injury, spinal cord injury (SCI) and multiple sclerosis. The search for cure of paralysis is yet to be found. Many ethnobotanical surveys have reported the use of medicinal plants by various ethnic communities in treating and curing paralysis. The present review discusses the use of medicinal plants in India for ameliorating and curing paralytic conditions, as well as discuses some of the important developments in future possible applications of medicinal plants in treatment of paralysis...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321123/comparative-analysis-of-women-with-notable-subjective-health-indicators-compared-with-participants-in-the-australian-longitudinal-study-on-women-s-health-cross-sectional-survey
#19
Christoph Schnelle, Eunice J Minford, Vanessa McHardy, Jane Keep
BACKGROUND: At least six communities with unusually good health and longevity have been identified, but their lifestyles aren't adopted widely. Informal evidence suggests that women associated with Universal Medicine (UM), a complementary medicine health care organization in Eastern Australia and the United Kingdom with normal lifestyles, also have several unusual health indicators. OBJECTIVE: Our objective was to determine how UM participants compared with women in the Australian population at large on a variety of health indicators...
January 10, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29320494/sexually-transmitted-infections-in-the-era-of-antiretroviral-based-hiv-prevention-priorities-for-discovery-research-implementation-science-and-community-involvement
#20
Jeanne M Marrazzo, Julia C Dombrowski, Kenneth H Mayer
Jeanne M. Marrazzo and colleagues join PLOS Medicine's Collection on the prevention, diagnosis, and treatment of STIs with a Perspective on HIV research imperatives in our time of effective viral suppression and pre-exposure prophylaxis.
January 2018: PLoS Medicine
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