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https://www.readbyqxmd.com/read/28430334/chondro-keratoprosthesis-an-alternative-to-ookp
#1
Louis Hoffart, Laurent Guyot
PURPOSE: To evaluate the use of cartilage as a potential graft material toward osteo-odontal tissue replacement in keratoprosthesis surgery. METHODS: We describe a modification of the osteo-odonto-keratoprosthesis surgery that involves the use of autologous auricular conchal cartilage graft (ACCG). In stage 1a, a full-thickness cheek mucosa graft was performed over the ocular surface. In stage 1b, ACCG was harvested via a retroauricular approach. An optical polymethyl-methacrylate cylinder was embedded into a double-layered fragment of cartilage and secured by cyanoacrylate glue...
April 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28429904/effect-of-lutein-supplementation-on-visual-function-in-nonproliferative-diabetic-retinopathy
#2
Ping-Chuan Zhang, Chang-Rui Wu, Zhi-Lun Wang, Li-Yuan Wang, Yue Han, Shu-Liu Sun, Qing-Shan Li, Le Ma
BACKGROUND AND OBJECTIVES: The purpose of this study was to determine whether supplementation with lutein improved visual function in patients with nonproliferative diabetic retinopathy (NPDR). METHODS AND STUDY DESIGN: In this randomized, double-blind, placebo-controlled trial, 31 patients with NPDR were assigned randomly to 10 mg/d of lutein or identical placebo for 36 weeks. Visual performance indices, including visual acuity (VA), contrast sensitivity (CS) and glare sensitivity (GS) at four different spatial frequencies, were measured at baseline, week 18 and 36...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28426857/spectacle-wear-among-children-in-a-school-based-program-for-ready-made-vs-custom-made-spectacles-in-india-a-randomized-clinical-trial
#3
Priya Morjaria, Jenifer Evans, Kaushik Murali, Clare Gilbert
Importance: Uncorrected refractive errors are the most common cause of visual impairment in children despite correction being highly cost-effective. Objective: To determine whether less expensive ready-made spectacles produce rates of spectacle wear at 3 to 4 months comparable to those of more expensive custom-made spectacles among eligible school-aged children. Design, Setting, and Participants: This noninferiority, double-masked, randomized clinical trial recruited children aged 11 to 15 years from January 12 through July 31, 2015, from government schools in urban and periurban areas surrounding Bangalore, India...
April 20, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28425235/a-study-on-the-validity-and-reliability-of-the-amblyopia-andstrabismus-questionnaire-a-sq-in-turkish
#4
Halise Çoşkun, Sevinç Taştan, Emine Iyigün, Fatih Mehmet Mutlu, Osman Melih Ceylan, Halil İbrahim Altinsoy
BACKGROUND/AIM: This study aims to evaluate the reliability and validity of the Amblyopia and Strabismus Questionnaire (AandSQ) that is translated into Turkish. MATERIALS AND METHODS: This is a methodological study. A total of 149 patients took part in the survey research between December 2012 and June 2014 in an university hospital, and 37 were retested. Cronbach's alpha coefficient was used for the questionnaire's reliability analysis. RESULTS: Cronbach's alpha coefficients for the subscales of fear of losing the better eye, distance estimation, visual disorientation, double vision, and social contact and appearance were found to be 0...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424453/comorbid-human-immunodeficiency-virus-hiv-and-muscle-specific-kinase-musk-myasthenia-gravis-a-case-report-and-literature-review
#5
Michael Sherpa, Ravi K Metai, Viki Kumar, Tinu Hirachan, Kawser U Ahmed, Sharon J Atkinson
BACKGROUND HIV infections with concomitant immunologically-mediated disorders have been frequently described but there has been little research on the association between HIV and myasthenia gravis. MuSK myasthenia gravis coexisting with HIV is an even a rarer entity and can occur as a part of immune restoration disease. We report the case of a patient with asymptomatic HIV infection who presented with new-onset MuSK myasthenia gravis. CASE REPORT A 44-year-old African-American woman with HIV since 2004 and on highly active antiretroviral therapy (HAART) presented to the ED with complains of double vision and difficulty swallowing for 2 weeks...
April 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28405391/red-fluorescence-of-the-triplefin-tripterygion-delaisi-is-increasingly-visible-against-background-light-with-increasing-depth
#6
Pierre-Paul Bitton, Ulrike K Harant, Roland Fritsch, Connor M Champ, Shelby E Temple, Nico K Michiels
The light environment in water bodies changes with depth due to the absorption of short and long wavelengths. Below 10 m depth, red wavelengths are almost completely absent rendering any red-reflecting animal dark and achromatic. However, fluorescence may produce red coloration even when red light is not available for reflection. A large number of marine taxa including over 270 fish species are known to produce red fluorescence, yet it is unclear under which natural light environment fluorescence contributes perceptively to their colours...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28388923/effectiveness-of-a-novel-mobile-health-education-intervention-peek-on-spectacle-wear-among-children-in-india-study-protocol-for-a-randomized-controlled-trial
#7
Priya Morjaria, Andrew Bastawrous, Gudlavalleti Venkata Satyanarayana Murthy, Jennifer Evans, Clare Gilbert
BACKGROUND: Uncorrected refractive errors are the commonest cause of visual loss in children despite spectacle correction being highly cost-effective. Many affected children do not benefit from correction as a high proportion do not wear their spectacles. Reasons for non-wear include parental attitudes, overprescribing and children being teased/bullied. Most school programmes do not provide health education for affected children, their peers, teachers or parents. The Portable Eye Examination Kit (Peek) will be used in this study...
April 8, 2017: Trials
https://www.readbyqxmd.com/read/28381256/double-or-nothing-red-flag-symptoms-of-critical-carotid-stenosis-a-case-report
#8
José Carlos Morán-Sánchez, Irene Gómez-Estévez, Yasmina El Berdei, José C Gómez-Sánchez, María E Ramos-Araque
BACKGROUND: Detailed knowledge of every possible manifestation of Internal Carotid Artery (ICA) disease is important. For improving detection and a timely adoption of secondary prevention procedures or treatments. Transient oculomotor nerve palsies have been described associated with stenosis or occlusion of the ICA. CASE PRESENTATION: We described a patient that develop a sequential combination of transient monocular loss of vision followed by binocular diplopia secondary to an unstable atherosclerotic preocclusive stenosis of an internal carotid artery previously treated with radiotherapy...
April 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28371482/additive-effects-and-safety-of-fixed-combination-therapy-with-1-brinzolamide-and-0-5-timolol-versus-1-dorzolamide-and-0-5-timolol-in-prostaglandin-treated-glaucoma-patients
#9
Makoto Aihara, Misato Adachi, Hiroshi Matsuo, Tetsuya Togano, Takeo Fukuchi, Noriyuki Sasaki
PURPOSE: To compare the additive effects and safety of 1% brinzolamide/0.5% timolol fixed combination (BTFC) versus the low-dose regimen of 1% dorzolamide/0.5% timolol fixed combination (DTFC) in patients with open-angle glaucoma and ocular hypertension (OAG/OH) following treatment with prostaglandin analogues (PGAs). METHODS: A prospective, randomized, double-masked, multicentre, parallel-group and active-controlled study included 201 Japanese OAG/OH patients who had been treated with PGA...
April 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28367386/a-case-of-miller-fisher-syndrome-and-literature-review
#10
Sumera Bukhari, Javier Taboada
Miller Fisher syndrome (MFS)  was first recognized by James Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. Later, it was described in 1956 by Charles Miller Fisher as a possible variant of Guillain-Barré syndrome (GBS). Here, we write a case of a patient with atypical presentation of this clinical triad as the patient presented with double vision initially due to unilateral ocular involvement that progressed to bilateral ophthalmoplegia. He developed weakness of the lower extremities and areflexia subsequently...
February 22, 2017: Curēus
https://www.readbyqxmd.com/read/28367195/the-effect-of-bilateral-intrapleural-infusion-of-lidocaine-with-fentanyl-versus-only-lidocaine-in-relieving-pain-after-coronary-artery-bypasses-surgery
#11
Kamran Shadvar, Sarvin Sanaie, Ata Mahmoodpoor, Mitra Safarpoor, Bahman Nagipour
BACKGROUND AND OBJECTIVE: Pain control during surgery in order to cause analgesia and reduce the somatic and autonomic response may decrease the morbidity. Intrapleural catheter embedding during surgery under direct vision of surgeon is safe and easy and without potential risk of thoracic epidural block. The aim of this study was to investigate the effect of bilateral intrapleural infusion of lidocaine with fentanyl versus only lidocaine in relieving pain after coronary artery bypass surgery...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28360792/orbital-myositis-evaluating-five-new-cases-regarding-clinical-and-radiological-features
#12
Özlem Önder, Rıfat Reha Bilgin, Aslı Köşkderelioğlu, Muhteşem Gedizlioğlu
Orbital myositis (OM) is an inflammatory disorder of the extraocular muscles. The signs and symptoms of OM are periorbital pain, eyelid swelling and redness, restricted ocular motility, and strabismus. There are at least two major forms, described by Benedikt GH Schoser, a limited oligosymptomatic ocular myositis (LOOM), which is associated with conjunctival injection only, and severe exophthalmic ocular myositis (SEOM), which presents with additional ptosis, chemosis, and proptosis. We report the clinical and radiological features of five patients with OM who were recently followed in our clinic...
June 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28325621/-diplopia-an-important-symptom-in-internal-medicine
#13
S Bidot, V Biousse
Diplopia is defined as "double vision" when looking at a single object. Monocular diplopia is related to an ocular disorder and must be differentiated from binocular diplopia which is secondary to ocular misalignment. The examination of the patient with binocular diplopia is often challenging for non-specialists. However, a careful and systematic clinical examination followed by targeted ancillary testing allows the clinician to localize the lesion along the oculomotor pathways. The lesion may involve the brainstem, the ocular motor nerves III, IV or VI, the neuromuscular junction, the extraocular ocular muscles, or the orbit...
March 18, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28325294/therapeutic-effect-of-novel-single-stranded-rnai-agent-targeting-periostin-in-eyes-with-retinal-neovascularization
#14
Takahito Nakama, Shigeo Yoshida, Keijiro Ishikawa, Yuki Kubo, Yoshiyuki Kobayashi, Yedi Zhou, Shintaro Nakao, Toshio Hisatomi, Yasuhiro Ikeda, Kazumasa Takao, Kazunori Yoshikawa, Akira Matsuda, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Akira Kudo, Koh-Hei Sonoda, Tatsuro Ishibashi
Retinal neovascularization (NV) due to retinal ischemia remains one of the principal causes of vision impairment in patients with ischemic retinal diseases. We recently reported that periostin (POSTN) may play a role in the development of preretinal fibrovascular membranes, but its role in retinal NV has not been determined. The purpose of this study was to examine the expression of POSTN in the ischemic retinas of a mouse model of oxygen-induced retinal NV. We also studied the function of POSTN on retinal NV using Postn KO mice and human retinal endothelial cells (HRECs) in culture...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28317678/quality-of-vision-after-wavefront-guided-laser-in-situ-keratomileusis-or-photorefractive-keratectomy-contralateral-eye-evaluation
#15
Michele D Lee, Edward E Manche
PURPOSE: To compare quality of vision between laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). SETTING: Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA. DESIGN: Prospective randomized case series. METHODS: Patients had refractive surgery, with 1 eye treated with LASIK and the other with PRK. Eyes were randomized for dominance. The patients completed a questionnaire assessing quality of vision in each eye at the initial visit and 1, 3, 6, and 12 months postoperatively...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28317674/clinical-and-patient-reported-outcomes-of-bilateral-implantation-of-a-2-5-diopter-multifocal-intraocular-lens
#16
Andrew Maxwell, Edward Holland, Lisa Cibik, Anna Fakadej, Gary Foster, Les Grosinger, Andrew Moyes, Stephen Nielsen, Steven Silverstein, Melissa Toyos, Arthur Weinstein, Scott Hartzell
PURPOSE: To assess the effectiveness and safety of a multifocal intraocular lens (IOL) with +2.5 diopter (D) additional power compared with a monofocal IOL. SETTING: Fifteen sites in the United States. DESIGN: Prospective randomized patient- and observer-masked clinical trial. METHODS: Randomized patients received multifocal or monofocal IOLs bilaterally. Visual acuity (33 cm, 40 cm, 53 cm, 60 cm, 4 m) was measured; safety was assessed through adverse event rates...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28300605/a-rapid-quantification-of-binocular-misalignment-without-recording-eye-movements-vertical-and-torsional-alignment-nulling
#17
Kara H Beaton, Mark J Shelhamer, Dale C Roberts, Michael C Schubert
BACKGROUND: Small, innate asymmetries between the left and right otolith organs can cause ocular misalignment with symptoms that include double vision and motion sickness. Additionally, ocular misalignment affects nearly 5% of the US population. We have developed a portable, non-invasive technology that uses subjective perception of binocular visual signals to estimate relative binocular alignment. NEW METHOD AND RESULTS: The Vertical Alignment Nulling (VAN) and Torsional Alignment Nulling (TAN) tests ask subjects to view one red and one blue line on a tablet computer while looking through color-matched red and blue filters so that each eye sees only one of the lines...
March 12, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28296722/design-methodology-and-baseline-data-of-the-personalized-addition-lenses-clinical-trial-pact
#18
RANDOMIZED CONTROLLED TRIAL
Xinping Yu, Binjun Zhang, Jinhua Bao, Junxiao Zhang, Ge Wu, Jinling Xu, Jingwei Zheng, Björn Drobe, Hao Chen
BACKGROUND: The aim of this study was to describe the design, methods, and baseline characteristics of children enrolled in the Personalized Addition lenses Clinical Trial (PACT). PACT aims to test the myopia control efficacy of progressive addition lenses (PALs) with personalized addition values compared with standard (+2.00 D) addition PALs and single vision lenses (SVLs). METHODS: PACT is a randomized, controlled, double-masked clinical trial. Two hundred eleven myopic Chinese children (7-12 years) were enrolled and randomized into 1 of the 3 following groups: personalized addition PALs; +2...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295290/fine-tuning-light-sensitivity-in-the-starry-flounder-platichthys-stellatus-retina-regional-variation-in-photoreceptor-cell-morphology-and-opsin-gene-expression
#19
Tom W Iwanicki, Iñigo Novales Flamarique, Juan Ausiό, Emily Morris, John S Taylor
Vertebrate colour vision relies on the differential expression of visual pigment proteins (opsins) in cone photoreceptors of the retina. The diversity of opsins and their retinal expression patterns appear greatest for animals that experience variable light habitats, as is the case with flatfishes. Yet, opsin repertoires and expression patterns in this group of fishes are poorly described. Here, we unveil the visual opsin expression patterns of juvenile starry flounder (Platichthys stellatus) and describe the localization of cone types, their visual pigments and opsin expression...
March 14, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28267687/hypertension-s-3-dilemmas-and-3-solutions-pharmacology-of-the-kidney-in-hypertension
#20
William A Pettinger
The Hypertension Community has 3 conflicting dilemmas: a goal systolic pressure of 120 mm Hg or less (the SPRINT Trials), 40% of our 60,000,000 hypertensives still sustain blood pressures above 140/90 mm Hg, and our most potent antihypertensive drug minoxidil sits on the sidelines, imprisoned in the Food and Drug Administration's Black Box designation. My solutions to these dilemmas are: (1) review of the facts of our most potent antihypertensive drug minoxidil which is essentially free of toxicity, (2) treatment focus on the fundamental cause of high blood pressure, that is excess dietary sodium and, (3) prevention of, and/or reversal of, the fundamental mechanism of worsening hypertension, arteriolar hypertrophy...
March 2017: Journal of Cardiovascular Pharmacology
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