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https://www.readbyqxmd.com/read/28325621/-diplopia-an-important-symptom-in-internal-medicine
#1
S Bidot, V Biousse
Diplopia is defined as "double vision" when looking at a single object. Monocular diplopia is related to an ocular disorder and must be differentiated from binocular diplopia which is secondary to ocular misalignment. The examination of the patient with binocular diplopia is often challenging for non-specialists. However, a careful and systematic clinical examination followed by targeted ancillary testing allows the clinician to localize the lesion along the oculomotor pathways. The lesion may involve the brainstem, the ocular motor nerves III, IV or VI, the neuromuscular junction, the extraocular ocular muscles, or the orbit...
March 18, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28325294/therapeutic-effect-of-novel-single-stranded-rnai-agent-targeting-periostin-in-eyes-with-retinal-neovascularization
#2
Takahito Nakama, Shigeo Yoshida, Keijiro Ishikawa, Yuki Kubo, Yoshiyuki Kobayashi, Yedi Zhou, Shintaro Nakao, Toshio Hisatomi, Yasuhiro Ikeda, Kazumasa Takao, Kazunori Yoshikawa, Akira Matsuda, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Akira Kudo, Koh-Hei Sonoda, Tatsuro Ishibashi
Retinal neovascularization (NV) due to retinal ischemia remains one of the principal causes of vision impairment in patients with ischemic retinal diseases. We recently reported that periostin (POSTN) may play a role in the development of preretinal fibrovascular membranes, but its role in retinal NV has not been determined. The purpose of this study was to examine the expression of POSTN in the ischemic retinas of a mouse model of oxygen-induced retinal NV. We also studied the function of POSTN on retinal NV using Postn KO mice and human retinal endothelial cells (HRECs) in culture...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28317678/quality-of-vision-after-wavefront-guided-laser-in-situ-keratomileusis-or-photorefractive-keratectomy-contralateral-eye-evaluation
#3
Michele D Lee, Edward E Manche
PURPOSE: To compare quality of vision between laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). SETTING: Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA. DESIGN: Prospective randomized case series. METHODS: Patients had refractive surgery, with 1 eye treated with LASIK and the other with PRK. Eyes were randomized for dominance. The patients completed a questionnaire assessing quality of vision in each eye at the initial visit and 1, 3, 6, and 12 months postoperatively...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28317674/clinical-and-patient-reported-outcomes-of-bilateral-implantation-of-a-2-5-diopter-multifocal-intraocular-lens
#4
Andrew Maxwell, Edward Holland, Lisa Cibik, Anna Fakadej, Gary Foster, Les Grosinger, Andrew Moyes, Stephen Nielsen, Steven Silverstein, Melissa Toyos, Arthur Weinstein, Scott Hartzell
PURPOSE: To assess the effectiveness and safety of a multifocal intraocular lens (IOL) with +2.5 diopter (D) additional power compared with a monofocal IOL. SETTING: Fifteen sites in the United States. DESIGN: Prospective randomized patient- and observer-masked clinical trial. METHODS: Randomized patients received multifocal or monofocal IOLs bilaterally. Visual acuity (33 cm, 40 cm, 53 cm, 60 cm, 4 m) was measured; safety was assessed through adverse event rates...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28300605/a-rapid-quantification-of-binocular-misalignment-without-recording-eye-movements-vertical-and-torsional-alignment-nulling
#5
Kara H Beaton, Mark J Shelhamer, Dale C Roberts, Michael C Schubert
BACKGROUND: Small, innate asymmetries between the left and right otolith organs can cause ocular misalignment with symptoms that include double vision and motion sickness. Additionally, ocular misalignment affects nearly 5% of the US population. We have developed a portable, non-invasive technology that uses subjective perception of binocular visual signals to estimate relative binocular alignment. NEW METHOD AND RESULTS: The Vertical Alignment Nulling (VAN) and Torsional Alignment Nulling (TAN) tests ask subjects to view one red and one blue line on a tablet computer while looking through color-matched red and blue filters so that each eye sees only one of the lines...
March 11, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28296722/design-methodology-and-baseline-data-of-the-personalized-addition-lenses-clinical-trial-pact
#6
RANDOMIZED CONTROLLED TRIAL
Xinping Yu, Binjun Zhang, Jinhua Bao, Junxiao Zhang, Ge Wu, Jinling Xu, Jingwei Zheng, Björn Drobe, Hao Chen
BACKGROUND: The aim of this study was to describe the design, methods, and baseline characteristics of children enrolled in the Personalized Addition lenses Clinical Trial (PACT). PACT aims to test the myopia control efficacy of progressive addition lenses (PALs) with personalized addition values compared with standard (+2.00 D) addition PALs and single vision lenses (SVLs). METHODS: PACT is a randomized, controlled, double-masked clinical trial. Two hundred eleven myopic Chinese children (7-12 years) were enrolled and randomized into 1 of the 3 following groups: personalized addition PALs; +2...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295290/fine-tuning-light-sensitivity-in-the-starry-flounder-platichthys-stellatus-retina-regional-variation-in-photoreceptor-cell-morphology-and-opsin-gene-expression
#7
Tom W Iwanicki, Iñigo Novales Flamarique, Juan Ausiό, Emily Morris, John S Taylor
Vertebrate colour vision relies on the differential expression of visual pigment proteins (opsins) in cone photoreceptors of the retina. The diversity of opsins and their retinal expression patterns appear greatest for animals that experience variable light habitats, as is the case with flatfishes. Yet, opsin repertoires and expression patterns in this group of fishes are poorly described. Here, we unveil the visual opsin expression patterns of juvenile starry flounder (Platichthys stellatus) and describe the localization of cone types, their visual pigments and opsin expression...
March 14, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28267687/hypertension-s-3-dilemmas-and-3-solutions-pharmacology-of-the-kidney-in-hypertension
#8
William A Pettinger
The Hypertension Community has 3 conflicting dilemmas: a goal systolic pressure of 120 mm Hg or less (the SPRINT Trials), 40% of our 60,000,000 hypertensives still sustain blood pressures above 140/90 mm Hg, and our most potent antihypertensive drug minoxidil sits on the sidelines, imprisoned in the Food and Drug Administration's Black Box designation. My solutions to these dilemmas are: (1) review of the facts of our most potent antihypertensive drug minoxidil which is essentially free of toxicity, (2) treatment focus on the fundamental cause of high blood pressure, that is excess dietary sodium and, (3) prevention of, and/or reversal of, the fundamental mechanism of worsening hypertension, arteriolar hypertrophy...
March 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28260274/a-case-of-double-vision
#9
Mohamed-Yassin Ms, Noorhida Baharudin, Norasyikin Mustafa
No abstract text is available yet for this article.
March 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28254131/double-vision-replicating-a-trial-showing-a-survival-benefit
#10
REVIEW
Milton Packer
No abstract text is available yet for this article.
March 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28245493/different-spatial-representations-guide-eye-and-hand-movements
#11
Matteo Lisi, Patrick Cavanagh
Our visual system allows us to localize objects in the world and plan motor actions toward them. We have recently shown that the localization of moving objects differs between perception and saccadic eye movements (Lisi & Cavanagh, 2015), suggesting different localization mechanisms for perception and action. This finding, however, could reflect a unique feature of the saccade system rather than a general dissociation between perception and action. To disentangle these hypotheses, we compared object localization between saccades and hand movements...
February 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28245346/n-acetylcarnosine-nac-drops-for-age-related-cataract
#12
REVIEW
Vincent Dj-P Dubois, Andrew Bastawrous
BACKGROUND: Cataract is the leading cause of world blindness. The only available treatment for cataract is surgery. Surgery requires highly-trained individuals with expensive operating facilities. Where these are not available, patients go untreated. A form of treatment that did not involve surgery would be a useful alternative for people with symptomatic cataract who are unable or unwilling to undergo surgery. If an eye drop existed that could reverse or even prevent progression of cataract, then this would be a useful additional treatment option...
February 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28238572/seronegative-myasthenia-gravis-associated-with-malignant-thymoma
#13
Jason Richards, James F Howard
Myasthenia gravis (MG) is generally caused by antibodies directed against the neuromuscular junction, including antibodies against the postsynaptic nicotinic acetylcholine receptor (AChR). Pathologic abnormalities of the thymus gland, including thymoma, are associated with MG. We report a 56-year-old woman who presented with double vision. Single fiber EMG confirmed myasthenia gravis. AChR, striational muscle and MuSK antibodies were absent in the serum. Chest CT demonstrated a malignant thymoma. We report the first case of seronegative myasthenia gravis associated with malignant thymoma...
February 2, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28228837/heroin-induced-exodeviation-masking-a-baseline-decompensated-esophoria
#14
Tina M Hakimi, John J Chen
Heroin and other opiate intake have been shown to have various effects on the brain, including the documentation of a small number of cases of strabismus from intake and withdrawal. Prior reports of heroin have focused on its tendency to cause diplopia, especially esodeviation upon withdrawal. The authors describe a 25-year-old woman who developed double vision from a decompensated esophoria where heroin use induced an exodeviation that transiently improved her diplopia. Measurements after acute heroin use confirmed by urinalysis revealed an improvement in her decompensated esophoria, reducing the previously documented esodeviation by more than half...
February 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28217399/delayed-and-isolated-oculomotor-nerve-palsy-following-minor-head-trauma
#15
Yu Nakagawa, Masahiro Toda, Shunsuke Shibao, Kazunari Yoshida
BACKGROUND: The purpose of this study was to consider the mechanism of isolated oculomotor nerve palsy after minor head trauma. CASE DESCRIPTION: We report a rare case of delayed and isolated oculomotor nerve palsy following minor head trauma. A 19-year-old boy complained of double vision 1 day after a minor head trauma. Neuro-ophthalmic examination showed isolated left oculomotor nerve palsy. Computed tomography and magnetic resonance imaging examination revealed no abnormal findings and steroid therapy was administered for a week...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28214473/pacific-island-health-inequities-forecast-to-grow-unless-profound-changes-are-made-to-health-systems-in-the-region
#16
Don Matheson, Kunhee Park, Taniela Sunia Soakai
Objective Twenty years ago the Pacific's health ministers developed a 'Healthy Islands' vision to lead health development in the subregion. This paper reports on a review of health development over this period and discusses the implications for the attainment of the health related Sustainable Development Goals.Methods The review used qualitative and quantitative methods. The qualitative review included conducting semi-structured interviews with Pacific Island Government Ministers and officials, regional agencies, health workers and community members...
February 20, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28203002/-role-of-different-scale-structures-of-titanium-implant-in-the-biological-behaviors-of-human-umbilical-vein-endothelial-cells
#17
N W Liang, L Shi, Y Huang, X L Deng
OBJECTIVE: To study the role of different scale structure of Ti implants on the biological behaviors of human umbilical vein endothelial cell (HUVECs) and to reveal the role of material surface topographical features on peri-implant angiogenesis. METHODS: Titanium (Ti) discs with different surface structures (Ti discs with smooth surface, Ti discs with nano scale structure, Ti discs with micro scale structure and Ti discs with micro/nano scale structure, named as SM-Ti, Nano-Ti, Micro-Ti and Micro/Nano-Ti, respectively) were prepared and their surface topographical features were confirmed via scanning electron microscopy (SEM) observation...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28199005/specialized-photoreceptor-composition-in-the-raptor-fovea
#18
Mindaugas Mitkus, Peter Olsson, Matthew B Toomey, Joseph C Corbo, Almut Kelber
The retinae of many bird species contain a depression with high photoreceptor density known as the fovea. Many species of raptors have two foveae, a deep central fovea and a shallower temporal fovea. Birds have six types of photoreceptors: rods, active in dim light, double cones that are thought to mediate achromatic discrimination, and four types of single cones mediating color vision. To maximize visual acuity, the fovea should only contain photoreceptors contributing to high-resolution vision. Interestingly, it has been suggested that raptors might lack double cones in the fovea...
February 15, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28182161/combination-verteporfin-photodynamic-therapy-ranibizumab-dexamethasone-in-choroidal-neovascularization-due-to-age-related-macular-degeneration-results-of-a-phase-ii-randomized-trial
#19
Ron P Gallemore, Josh Wallsh, Henry L Hudson, Allen C Ho, Richard Chace, Joel Pearlman
PURPOSE: To assess whether combination therapy (CT) reduces retreatments when compared to ranibizumab monotherapy (RM), while safely maintaining similar vision outcomes. METHODS: In this 24-month trial, patients with age-related macular degeneration (AMD) were randomized to 1) quarter-fluence or 2) half-fluence triple therapy (verteporfin photodynamic therapy [vPDT] + ranibizumab + dexamethasone), 3) half-fluence double therapy (vPDT + ranibizumab), or 4) RM. The primary outcomes were number of retreatment visits and change from baseline in visual acuity (VA) at 12 months...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28166717/protanopia-red-color-blindness-in-medaka-a-simple-system-for-producing-color-blind-fish-and-testing-their-spectral-sensitivity
#20
Noriko Homma, Yumi Harada, Tamaki Uchikawa, Yasuhiro Kamei, Shoji Fukamachi
BACKGROUND: Color perception is important for fish to survive and reproduce in nature. Visual pigments in the retinal photoreceptor cells are responsible for receiving light stimuli, but the function of the pigments in vivo has not been directly investigated in many animals due to the lack of color-blind lines and appropriate color-perception tests. METHODS: In this study, we established a system for producing color-blind fish and testing their spectral sensitivity...
February 6, 2017: BMC Genetics
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